10 Best Supplements for Energy (2026) Reviewed
Feeling drained before lunch hits? You’re not alone. Whether it’s the demands of a busy lifestyle, poor sleep quality, or simply getting older, low energy levels affect millions of people daily. While proper sleep, nutrition, and exercise form the foundation of lasting vitality, the right supplements can provide meaningful support for your body’s natural energy production systems.
Unlike caffeine-heavy energy drinks that deliver a quick spike followed by an inevitable crash, the best energy supplements work at the cellular level. They support mitochondrial function, replenish depleted nutrients, help your body adapt to stress, and optimize the pathways that convert food into usable energy. The key is understanding which supplements address your specific needs—whether that’s supporting ATP production, managing stress-related fatigue, or correcting a nutrient deficiency.
We researched dozens of products, analyzed third-party testing data, and evaluated formulations to identify the supplements that deliver real results. Our picks span cellular energy boosters like CoQ10, adaptogenic herbs for stress-related fatigue, essential B-vitamins, and performance-focused compounds. Here are the best energy supplements for 2026.
Table of Contents
- Quick Comparison Table
- Energy Supplements by Type
- Individual Product Reviews
- Buying Guide
- How to Take Energy Supplements
- Potential Benefits
- Safety Considerations
- Frequently Asked Questions
- Bottom Line
Quick Comparison Table
| Product | Form | Serving Size | Key Differentiator | Best For | Winner |
|---|---|---|---|---|---|
| Life Extension Super Ubiquinol CoQ10 | Softgels | 1 softgel (100mg) | Ubiquinol + shilajit for enhanced mitochondrial support | Cellular energy & anti-aging | 🏆 TOP PICK |
| Thorne B-Complex #12 | Capsules | 1 capsule | Active methylated B-vitamins with extra B12 | Daily energy production | 🥇 Best B-Complex |
| Nutricost KSM-66 Ashwagandha | Capsules | 1 capsule (600mg) | Clinically studied KSM-66 extract with BioPerine | Stress-related fatigue | 🥇 Best Adaptogen |
| Qunol Ultra CoQ10 | Softgels | 1 softgel (100mg) | 3x better absorption, water & fat soluble | Budget CoQ10 option | 🥇 Best Value |
| NOW Rhodiola 500mg | Veg Capsules | 1 capsule (500mg) | Standardized 3% rosavins, 1% salidroside | Mental fatigue & focus | |
| Jarrow Formulas Acetyl L-Carnitine | Veg Capsules | 1 capsule (500mg) | Crosses blood-brain barrier for mental energy | Brain energy & fat metabolism | |
| Thorne Iron Bisglycinate | Capsules | 1 capsule (25mg) | Non-constipating, highly absorbable chelated iron | Iron deficiency fatigue | 🥇 Best Iron |
| Real Mushrooms Cordyceps | Capsules | 2 capsules | 100% fruiting body extract, verified beta-glucans | Athletic performance | |
| Optimum Nutrition Micronized Creatine | Powder | 1 tsp (5g) | Pure creatine monohydrate, micronized for mixing | Physical performance & ATP | 🥇 Best for Athletes |
| Thorne Stress B-Complex | Capsules | 1 capsule | Extra B5 for adrenal support during stress | High-stress lifestyles |
Energy Supplements by Type
Cellular Energy Supporters (CoQ10, ALCAR, Creatine)
These supplements work at the mitochondrial level to support your body’s ATP production—the actual energy currency your cells use. CoQ10 is essential for the electron transport chain, acetyl-L-carnitine shuttles fatty acids into mitochondria for fuel, and creatine helps regenerate ATP during high-intensity activity. Best for: age-related energy decline, physical performance, and those on statin medications (which deplete CoQ10).
Adaptogenic Herbs (Ashwagandha, Rhodiola, Cordyceps)
Adaptogens help your body respond to stress more efficiently, which can reduce the energy-draining effects of chronic stress and cortisol elevation. They don’t provide stimulation but rather support balanced energy throughout the day. Best for: stress-related fatigue, burnout recovery, and those who want sustained energy without stimulants.
B-Vitamins
B-vitamins are essential cofactors in virtually every energy-producing pathway in your body. They help convert carbohydrates, fats, and proteins into usable energy. Deficiencies—especially B12 and folate—are common causes of fatigue. Best for: vegetarians/vegans, those with absorption issues, and anyone with a less-than-optimal diet.
Iron Supplements
Iron is crucial for oxygen transport and energy production. Iron deficiency is one of the most common nutritional deficiencies worldwide and a leading cause of fatigue, particularly in menstruating women, athletes, and vegetarians. Best for: those with confirmed iron deficiency or increased iron needs.
Individual Product Reviews
Life Extension Super Ubiquinol CoQ10 with Enhanced Mitochondrial Support — Best Overall
This premium CoQ10 formula combines the most bioavailable form of CoQ10 (ubiquinol) with shilajit, an adaptogen traditionally used to enhance mitochondrial energy production.
Life Extension’s Super Ubiquinol stands apart from standard CoQ10 supplements by using ubiquinol instead of ubiquinone. Research suggests ubiquinol absorbs up to eight times better than conventional CoQ10, making it significantly more effective at raising blood levels. The addition of shilajit—a mineral-rich compound from the Himalayas—provides complementary support for mitochondrial function.
This supplement is particularly valuable for adults over 40, as natural CoQ10 production declines with age. It’s also beneficial for those taking statin medications, which can deplete CoQ10 levels. The formula is manufactured in the USA, third-party tested, and backed by Life Extension’s 40+ years of research-focused supplement development.
Key Specifications:
- 100mg ubiquinol per softgel
- Enhanced with shilajit fulvic acid complex
- 60 softgels per bottle (2-month supply)
- Non-GMO, gluten-free
- Third-party tested
Considerations: Premium pricing reflects the higher-quality ubiquinol form. Those on a budget may prefer ubiquinone-based alternatives, though absorption will be lower.
Thorne B-Complex #12 — Best B-Complex
Thorne’s flagship B-complex delivers all eight B-vitamins in their active, methylated forms with extra B12 for enhanced energy support.
What separates Thorne’s B-Complex #12 from generic B-vitamins is the use of active forms that your body can use immediately—no conversion required. This includes methylcobalamin (active B12), methylfolate (active folate), and pyridoxal 5′-phosphate (active B6). For people with MTHFR gene variants or absorption issues, these active forms can make a significant difference in how effectively the vitamins work.
The extra B12 in this formula specifically targets energy production and nervous system support. Thorne is one of the most trusted names in professional-grade supplements, chosen by over 100 professional sports teams and consistently ranked among the top brands by healthcare practitioners. Every batch is third-party tested and NSF Certified for Sport.
Key Specifications:
- All 8 B-vitamins in active forms
- Extra vitamin B12 (as methylcobalamin)
- Includes choline for added support
- 60 capsules per bottle
- Third-party certified, NSF Certified for Sport available
Considerations: Some users may find the active B-vitamins more potent than expected. Starting with one capsule and assessing tolerance is recommended.
Nutricost KSM-66 Ashwagandha — Best Adaptogen
This clinically studied ashwagandha extract may help reduce stress-related fatigue and support sustained energy through cortisol modulation.
KSM-66 is the most extensively researched ashwagandha extract on the market, backed by multiple clinical trials examining its effects on stress, energy, and cognitive function. Nutricost’s formulation delivers 600mg per capsule with a minimum 5% withanolides—the active compounds responsible for ashwagandha’s adaptogenic properties. The addition of BioPerine (black pepper extract) enhances absorption.
Unlike stimulants that provide temporary energy spikes, ashwagandha works by helping your body adapt to stress more efficiently. Research suggests it may help reduce cortisol levels, which can be elevated during chronic stress and contribute to fatigue. Users typically notice effects after 2-4 weeks of consistent use.
Key Specifications:
- 600mg organic KSM-66 extract per capsule
- Standardized to 5% withanolides (30mg per capsule)
- Enhanced with BioPerine for absorption
- 60 vegetarian capsules per bottle
- Manufactured in GMP-certified facility
Considerations: Ashwagandha may interact with thyroid medications and is not recommended during pregnancy. Effects build over time rather than providing immediate energy.
Qunol Ultra CoQ10 — Best Value
With patented water and fat-soluble technology, Qunol delivers 3x better absorption than standard CoQ10 at an accessible price point.
Qunol has earned its position as the #1 cardiologist-recommended form of CoQ10 through its patented absorption technology. Standard CoQ10 (ubiquinone) is notoriously difficult to absorb—it doesn’t dissolve in water and dissolves poorly in fat. Qunol’s formulation is both water and fat-soluble, allowing it to absorb efficiently regardless of what you eat it with.
This makes Qunol an excellent choice for those who want effective CoQ10 supplementation without the premium price of ubiquinol. The 120-count bottle provides a 4-month supply at one softgel daily, making it one of the most economical options per serving. It’s particularly popular among statin users looking to replenish CoQ10 levels.
Key Specifications:
- 100mg CoQ10 (ubiquinone) per softgel
- Patented 100% water and fat-soluble formula
- 120 softgels per bottle (4-month supply)
- Gluten-free
- Clinical studies support 3x better absorption
Considerations: Uses ubiquinone rather than ubiquinol. While absorption is enhanced, ubiquinol may still be more effective for older adults whose bodies convert ubiquinone less efficiently.
NOW Rhodiola 500mg — Best for Mental Fatigue
This standardized rhodiola extract may help combat mental fatigue and brain fog while supporting the body’s stress response.
Rhodiola rosea has been used for centuries in traditional medicine across Europe and Asia as a tonic for fatigue and stress. Modern research supports its classification as an adaptogen, with studies suggesting it may help reduce mental fatigue, improve focus, and support cognitive function during periods of stress or sleep deprivation.
NOW Foods standardizes their extract to 3% rosavins and 1% salidroside—the specific ratio found in the natural root and used in most clinical research. This ensures consistent potency between batches. The vegetarian capsules are suitable for various dietary preferences, and NOW Foods’ reputation for quality and value makes this an accessible option.
Key Specifications:
- 500mg rhodiola root extract per capsule
- Standardized to 3% rosavins, 1% salidroside
- 60 vegetarian capsules per bottle
- Vegan, gluten-free, non-GMO
- GMP quality assured
Considerations: Best taken on an empty stomach for optimal absorption. Not recommended for pregnant or nursing women. May cause mild stimulation in some users if taken late in the day.
Jarrow Formulas Acetyl L-Carnitine — Best for Brain Energy
This brain-specific form of carnitine crosses the blood-brain barrier to support both mental energy and cellular energy production.
Acetyl-L-carnitine (ALCAR) is the acetylated form of L-carnitine, giving it the unique ability to cross the blood-brain barrier. While standard L-carnitine primarily supports fat metabolism in muscles, ALCAR provides additional cognitive support, making it valuable for mental energy and focus alongside physical energy.
Jarrow Formulas is known for science-based formulations, and their ALCAR delivers 500mg per capsule—a clinically relevant dose. Research suggests ALCAR may be particularly beneficial for age-related cognitive decline and chronic fatigue. It works by supporting the transport of fatty acids into mitochondria for ATP production while also providing antioxidant protection for brain cells.
Key Specifications:
- 500mg acetyl L-carnitine per capsule
- 120 vegetarian capsules per bottle
- Non-GMO, gluten-free
- Suitable for vegetarians
- Science-based formulation
Considerations: Best taken on an empty stomach for optimal absorption. Those with thyroid conditions should consult a healthcare provider, as carnitine may affect thyroid hormone levels.
Thorne Iron Bisglycinate — Best Iron Supplement
This highly absorbable, chelated iron form provides effective iron supplementation without the gastrointestinal side effects common with other forms.
Iron deficiency is one of the most common causes of fatigue, affecting up to 16% of some populations. However, many people avoid iron supplements due to constipation and stomach upset. Thorne’s Iron Bisglycinate uses Ferrochel—a patented form where iron is bound to the amino acid glycine—which research shows absorbs well without the typical GI side effects.
Each capsule provides 25mg of elemental iron, appropriate for addressing deficiency while minimizing risk of iron overload. The formula is NSF Certified for Sport, making it suitable for athletes who have increased iron needs due to training. Women of childbearing age, vegetarians, and frequent blood donors may particularly benefit.
Key Specifications:
- 25mg elemental iron (as Ferrochel ferrous bisglycinate chelate)
- 60 capsules per bottle
- NSF Certified for Sport
- Non-constipating formula
- Third-party tested
Considerations: Iron supplementation should ideally be guided by blood testing, as excess iron can be harmful. Keep out of reach of children—iron overdose is a serious risk. Take separately from calcium, coffee, and tea for best absorption.
Real Mushrooms Cordyceps — Best Functional Mushroom
Made from 100% fruiting body extract with verified beta-glucans, this cordyceps supplement may support athletic performance and natural energy.
Cordyceps mushrooms have been used in traditional Chinese medicine for centuries, prized for their potential to enhance energy, stamina, and oxygen utilization. Real Mushrooms distinguishes itself by using only the fruiting body of Cordyceps militaris—not mycelium grown on grain, which can dilute the active compounds with starch.
Each batch is third-party tested to verify beta-glucan content (minimum 8%), ensuring you get the bioactive compounds responsible for cordyceps’ benefits. The company is founded by a family with over 40 years of mushroom growing experience, and their commitment to transparency includes providing certificates of analysis. Athletes and active individuals may find cordyceps supports oxygen uptake and exercise performance.
Key Specifications:
- 500mg per capsule (2-capsule serving)
- 100% Cordyceps militaris fruiting body extract
- Verified 8% beta-glucans
- 120 capsules per bottle (60 servings)
- USDA Organic, vegan, non-GMO
Considerations: Effects may take 2-4 weeks of consistent use to become noticeable. Those with mushroom allergies should avoid this product.
Optimum Nutrition Micronized Creatine Monohydrate — Best for Athletes
The gold standard in creatine supplementation, this pure micronized powder supports ATP regeneration for improved strength, power, and exercise performance.
Creatine monohydrate is one of the most extensively researched supplements in sports nutrition, with consistent evidence supporting its ability to enhance high-intensity exercise performance, increase strength, and support muscle recovery. Optimum Nutrition’s micronized formula dissolves easily in liquids without grittiness.
Beyond athletic performance, emerging research suggests creatine may support cognitive function and cellular energy in general. Each serving delivers 5g of pure creatine monohydrate—the clinically studied dose—with no fillers or additives. The product is banned substance tested, making it suitable for competitive athletes.
Key Specifications:
- 5g creatine monohydrate per serving
- Micronized for easy mixing
- 60 servings per container (300g)
- Unflavored, mixes with any beverage
- Banned substance tested
Considerations: May cause temporary water retention during the loading phase. Stay well-hydrated when supplementing with creatine. Benefits require consistent daily use.
Thorne Stress B-Complex — Best for High-Stress Lifestyles
This specialized B-complex includes extra vitamin B5 (pantothenic acid) to support adrenal function during periods of chronic stress.
When you’re under chronic stress, your adrenal glands work overtime producing cortisol and other stress hormones. This process depletes B-vitamins—particularly B5, which is essential for adrenal function. Thorne’s Stress B-Complex provides extra B5 alongside all eight B-vitamins in their active, tissue-ready forms.
This formula is designed specifically for people dealing with ongoing stress, demanding careers, or recovery from burnout. The active forms (methylcobalamin, methylfolate, P5P) ensure optimal absorption regardless of genetic variations that affect B-vitamin metabolism. Like all Thorne products, it’s third-party tested and free from common allergens.
Key Specifications:
- All 8 B-vitamins in active forms
- Extra vitamin B5 for adrenal support
- Includes choline
- 60 capsules per bottle
- Third-party certified, gluten-free
Considerations: Those not experiencing high stress may find the standard B-Complex #12 more appropriate. Taking B-vitamins late in the day may affect sleep in some individuals.
Buying Guide: What to Look for in Energy Supplements
Key Quality Indicators
Third-party testing by organizations like NSF International, USP, or ConsumerLab provides assurance that what’s on the label matches what’s in the bottle. Look for supplements from established brands with transparent sourcing and manufacturing practices. GMP (Good Manufacturing Practice) certification indicates the facility follows quality standards.
Form Matters
For CoQ10, ubiquinol absorbs better than ubiquinone, especially for adults over 40. For B-vitamins, active/methylated forms (methylcobalamin, methylfolate) are more effective for people with MTHFR variants. For iron, bisglycinate and other chelated forms cause fewer GI side effects than ferrous sulfate.
Dosage Considerations
More isn’t always better. Look for products that provide clinically studied doses rather than mega-doses that exceed what research supports. For example, 100-200mg of CoQ10, 500-600mg of ashwagandha extract, and 5g of creatine monohydrate are well-established effective doses.
Red Flags to Avoid
Be wary of proprietary blends that don’t disclose individual ingredient amounts, products with excessive artificial additives, and supplements making dramatic disease treatment claims. Also avoid mushroom supplements that use mycelium grown on grain rather than fruiting bodies, as these contain significant amounts of starch filler.
How to Take Energy Supplements
Timing Recommendations
Fat-soluble supplements like CoQ10 and vitamin D absorb best when taken with a meal containing fat. B-vitamins are generally best taken in the morning, as they may interfere with sleep if taken late. Adaptogenic herbs like ashwagandha can be taken any time, though some prefer evening dosing for its calming effects.
Cycling Considerations
Most energy supplements can be taken continuously, but some practitioners recommend cycling adaptogens (such as 8 weeks on, 2 weeks off) to maintain effectiveness. CoQ10, B-vitamins, and iron are typically taken consistently without cycling.
Stacking Strategies
Combining supplements that work through different mechanisms can provide comprehensive energy support. A common stack includes CoQ10 for cellular energy, a B-complex for metabolic support, and an adaptogen for stress resilience. Avoid stacking multiple stimulating adaptogens (like rhodiola and ginseng together) without understanding your tolerance.
Potential Benefits of Energy Supplements
Cellular Energy Production
CoQ10, acetyl-L-carnitine, and creatine support ATP production at the mitochondrial level. Research suggests CoQ10 supplementation may help reduce feelings of fatigue, particularly in people with lower baseline levels. A 2022 review found that CoQ10 supplementation significantly reduced fatigue in various study populations.
Stress Adaptation
Adaptogenic herbs like ashwagandha and rhodiola may help the body respond to stress more efficiently. Studies suggest KSM-66 ashwagandha may help reduce cortisol levels and improve stress-related symptoms. Rhodiola has been studied for its potential to reduce mental fatigue during stressful periods.
Nutrient Repletion
B-vitamin and iron supplements can help correct deficiencies that commonly cause fatigue. Since these nutrients are essential for energy metabolism and oxygen transport, addressing deficiencies often results in noticeable energy improvements.
Safety Considerations
Potential Side Effects
Most energy supplements are well-tolerated at recommended doses. CoQ10 rarely causes side effects but may include mild digestive upset. B-vitamins can cause bright yellow urine (harmless) and rarely nausea at high doses. Iron supplements may cause constipation or stomach upset, though bisglycinate forms minimize this risk.
Who Should Use Caution
Pregnant or nursing women should consult healthcare providers before starting any supplement regimen. Those taking blood thinners should be aware that CoQ10 may affect anticoagulant activity. People with thyroid conditions should discuss carnitine supplementation with their doctor. Iron supplements require caution in people with hemochromatosis or other iron overload conditions.
Drug Interactions
CoQ10 may reduce the effectiveness of warfarin and other blood thinners. Ashwagandha may interact with thyroid medications, sedatives, and immunosuppressants. Iron supplements should be taken separately from certain antibiotics and thyroid medications. Always disclose all supplements to healthcare providers.
Frequently Asked Questions
What is the best supplement for instant energy?
Unlike caffeine, most evidence-based energy supplements work over time rather than instantly. For relatively quick effects (within days to weeks), B-vitamin supplementation can help if you have a deficiency. Rhodiola may provide noticeable effects within a week for some users. For truly instant energy, caffeine remains the most effective option, but it comes with tolerance and crash issues that these supplements avoid.
Can I take multiple energy supplements together?
Yes, combining supplements that work through different mechanisms is generally safe and may be more effective than single supplements alone. A reasonable combination might include CoQ10 for cellular energy, a B-complex for metabolic support, and an adaptogen for stress resilience. Avoid excessive stimulation by not combining multiple stimulating adaptogens without understanding your tolerance.
How long until I notice results from energy supplements?
Timeline varies by supplement and individual. B-vitamins may improve energy within days if correcting a deficiency. CoQ10 typically takes 2-4 weeks to reach optimal blood levels. Adaptogenic herbs like ashwagandha usually require 4-8 weeks of consistent use for full effects. Creatine begins working within the first week for exercise performance.
Are energy supplements safe to take every day?
Most energy supplements are designed for daily use and have good safety profiles at recommended doses. CoQ10, B-vitamins, and iron (if needed) can be taken indefinitely. Some practitioners recommend cycling adaptogens periodically, though evidence for this practice is limited. Always follow product recommendations and consult healthcare providers for long-term use.
Should I take CoQ10 as ubiquinone or ubiquinol?
Ubiquinol is the active, reduced form of CoQ10 that absorbs better, particularly in adults over 40 whose bodies convert ubiquinone less efficiently. However, quality ubiquinone formulas with enhanced absorption (like Qunol’s water/fat-soluble technology) can still be effective and cost less. If budget allows, ubiquinol is generally preferred for maximum benefit.
Do energy supplements work if I’m not deficient in anything?
Some supplements provide benefits regardless of deficiency status. Creatine enhances ATP regeneration in anyone doing high-intensity exercise. CoQ10 levels decline naturally with age, so supplementation may benefit older adults even without clinical deficiency. Adaptogens may help anyone dealing with stress. However, B-vitamins and iron primarily benefit those with low levels.
Can energy supplements replace sleep?
No supplement can replace adequate sleep. Energy supplements may help you function better during periods of sleep deprivation, but they don’t provide the same restorative benefits as actual sleep. Chronic use of supplements to compensate for poor sleep is not recommended and may mask underlying sleep issues that need addressing.
Are natural energy supplements better than caffeine?
They serve different purposes. Caffeine provides immediate, noticeable stimulation but comes with tolerance, dependence, and crash issues. Energy supplements like CoQ10, B-vitamins, and adaptogens support your body’s natural energy systems without stimulation or crashes but take longer to work. Many people use both: caffeine for acute needs and supplements for foundational support.
Bottom Line
For most people seeking overall energy support: Life Extension Super Ubiquinol CoQ10 provides premium cellular energy support with superior absorption and mitochondrial-enhancing shilajit.
For budget-conscious buyers: Qunol Ultra CoQ10 delivers effective CoQ10 supplementation with enhanced absorption at an accessible price point.
For stress-related fatigue: Nutricost KSM-66 Ashwagandha offers clinically studied adaptogenic support to help your body manage stress and maintain balanced energy.
For comprehensive B-vitamin support: Thorne B-Complex #12 provides all essential B-vitamins in active, bioavailable forms for optimal energy metabolism.
For athletes and physical performance: Optimum Nutrition Micronized Creatine supports ATP regeneration for improved strength, power, and exercise capacity.
For suspected iron deficiency: Thorne Iron Bisglycinate offers highly absorbable iron without the GI side effects common with other iron forms.
