Best NMN & NAD+ Supplements for Longevity (2026) – Top 10 Reviewed
NAD+ (nicotinamide adenine dinucleotide) levels decline significantly as we age, and supplementing with NAD+ precursors like NMN has become one of the most science-backed approaches to supporting cellular health and longevity. These supplements help replenish the coenzymes your mitochondria need to produce energy efficiently.
The best NAD+ supplements combine high-purity precursors with absorption-enhancing delivery systems like liposomal formulas or sublingual lozenges. Here are our top 10 picks for 2026.
| Product | Key Ingredients | Servings | Form | Best For |
|---|---|---|---|---|
| Selerb NAD+ Supplements for Men | NAD+, Resveratrol, CoQ10 | 60 | Capsules | Best Overall |
| Timeline Mitopure Urolithin A Gummies | Urolithin A 500mg | 60 | Gummies | Best Clinically Proven |
| XKQ NAD Plus Liposomal | NMN, NAD, NR, Resveratrol | 60 | Capsules | Best Liposomal Formula |
| NAD Supplement 1500mg Liposomal | NAD+ NR, Resveratrol | 120 | Capsules | Best High-Dose |
| Sublingual NMN 500mg + Resveratrol | NMN 500mg, Trans-Resveratrol 400mg | 120 | Lozenges | Best Sublingual |
| NAD+ Resveratrol 61800mg Formula | NAD+ 1200mg, Resveratrol, CoQ10 | 90 | Capsules | Best Value |
| Timeline Mitopure Powder 500mg | Urolithin A 500mg | 30 | Powder | Best Powder Form |
| Sublingual NMNH 120 Count | NMNH, NR, Resveratrol, TMG | 120 | Lozenges | Best NMNH Formula |
| Liposomal NAD+ 1200mg with Resveratrol | NAD+ 1200mg, Trans-Resveratrol | 100 | Softgels | Best Softgels |
| Luma Nutrition NAD+ 1000mg | Pure NAD+ 500mg per capsule | 60 | Capsules | Best Budget Option |
1. Selerb NAD+ Supplements for Men – Best Overall
Why it stands out: This comprehensive formula combines NAD+ with nitric oxide boosters, making it unique among longevity supplements. It targets both cellular energy and cardiovascular health in one capsule, addressing multiple age-related concerns simultaneously.
Selerb’s formula goes beyond basic NAD+ supplementation by including Resveratrol, CoQ10, L-Citrulline, and Lycopene. The CoQ10 works synergistically with NAD+ to support mitochondrial function—these two compounds work in tandem inside your mitochondria to produce ATP (cellular energy). Meanwhile, L-Citrulline enhances blood flow for better nutrient delivery throughout your body, including to your brain.
The inclusion of Lycopene is a smart addition often overlooked in longevity formulas. This powerful antioxidant from tomatoes has strong evidence for cardiovascular and prostate support. At 60 capsules per bottle, you get a full month’s supply with a two-capsule daily serving. The capsules are reasonably sized and easy to swallow.
Pros:
- Multi-target formula addresses energy, circulation, and prostate health
- Includes CoQ10 for enhanced mitochondrial support
- Good value for a comprehensive stack
- Well-balanced dosages across all ingredients
Cons:
- Marketed specifically for men, though ingredients benefit both genders
- Some may prefer a simpler, single-ingredient formula
Best for: Men over 40 looking for an all-in-one longevity and vitality supplement without managing multiple bottles.
2. Timeline Mitopure Urolithin A Gummies – Best Clinically Proven
Why it stands out: Timeline’s Mitopure is backed by multiple clinical trials showing improved muscle strength and endurance. Urolithin A triggers mitophagy—the process of clearing damaged mitochondria so new, healthy ones can replace them. This is arguably the most rigorously tested longevity compound available to consumers.
Unlike NMN or NR, Urolithin A works by activating mitophagy rather than boosting NAD+ directly. Think of it as taking out the cellular trash—damaged mitochondria accumulate as we age and drag down the performance of healthy ones. Clinical studies show 500mg daily can improve muscle strength and exercise capacity in as little as 8 weeks, with participants showing measurable improvements in biomarkers of mitochondrial health.
The gummy form makes daily compliance easy, and they actually taste good—a rare combination in the longevity space. Yes, they contain added sugars, but the amount is minimal in the context of an overall healthy diet. Timeline is a science-first company spun out of the Swiss Federal Institute of Technology in Lausanne, and their Mitopure is manufactured under strict quality controls.
What makes Urolithin A particularly interesting is that it addresses a different mechanism than NAD+ precursors. While NMN and NR focus on boosting NAD+ levels to fuel existing mitochondria, Urolithin A helps you build a better mitochondrial population overall. Some longevity enthusiasts take both.
Pros:
- Most clinically validated longevity ingredient available
- Convenient gummy format with good taste
- Targets mitochondrial health through a different mechanism than NAD+ precursors
- Backed by a reputable research-focused company
Cons:
- Premium price point reflects clinical research investment
- Contains sugars typical of gummies
- Only 60 gummies per container (one-month supply)
Best for: Those who want the strongest clinical evidence behind their longevity supplement and don’t mind paying for research-backed quality.
3. XKQ NAD Plus Liposomal – Best Liposomal Formula
Why it stands out: This liposomal delivery system protects NAD+ and NMN from degradation in the digestive tract, potentially increasing absorption by 3-5x compared to standard capsules. It’s the delivery method that makes this formula special.
XKQ packs multiple NAD+ precursors into one formula: NMN, NAD+, and Nicotinamide Riboside (NR). This triple-precursor approach hedges your bets—different precursors may work better for different individuals based on genetics and gut microbiome composition. The liposomal encapsulation uses phospholipid bubbles to shuttle ingredients past stomach acid and into your cells more efficiently.
At 910mg total per serving with 60 servings per bottle, it offers good potency for the price. The inclusion of Resveratrol adds synergistic anti-aging benefits by activating sirtuins—the longevity genes that NAD+ powers. Think of NAD+ as the fuel and sirtuins as the engine; Resveratrol helps turn that engine on.
The two-capsule daily dose is easy to manage, and many users report noticeable improvements in energy within the first week. The liposomal technology is the same used in high-end IV vitamin therapies, now available in capsule form.
Pros:
- Liposomal delivery enhances bioavailability significantly
- Combines multiple NAD+ precursors for comprehensive coverage
- 60-day supply at recommended dosing
- Includes Resveratrol for sirtuin activation
Cons:
- Requires taking 2 capsules daily for full dose
- Multiple precursors may be redundant for some users
Best for: Anyone who has tried standard NAD+ supplements without noticeable results—the enhanced absorption may make the difference.
4. NAD Supplement 1500mg Liposomal – Best High-Dose
Why it stands out: At 1500mg per serving, this is one of the highest-potency NAD+ supplements available, making it ideal for those who want aggressive dosing for noticeable results. If you’re over 50 or have tried lower doses without success, this formula delivers.
This formula combines Nicotinamide Riboside with Resveratrol in a liposomal delivery system. The 120-capsule bottle provides a 60-day supply at the recommended 2 capsules daily. Liposomal encapsulation helps this high dose actually reach your cells rather than being broken down during digestion—a critical advantage when you’re paying for premium ingredients.
The addition of Resveratrol activates sirtuins, the longevity genes that NAD+ fuels. Research suggests that NAD+ and Resveratrol work synergistically: NAD+ provides the fuel, while Resveratrol helps activate the cellular machinery that uses it. This combination mirrors protocols used in cutting-edge longevity research.
For those who have experimented with lower doses and want to see if more is better, this high-dose formula provides a clear step up. Some longevity researchers believe that restoring NAD+ to youthful levels requires higher doses than what most supplements provide, especially for those over 50 whose levels have declined significantly.
Pros:
- High potency for those who need stronger dosing
- Liposomal delivery protects ingredients from digestive breakdown
- Includes complementary Resveratrol for sirtuin activation
- 60-day supply provides good value for the dosage
Cons:
- High dose may not be necessary for everyone
- 2 capsules required daily
- May be overkill for those new to NAD+ supplementation
Best for: Those over 50 or anyone looking for maximum NAD+ replenishment after lower doses haven’t delivered results.
5. Sublingual NMN 500mg + Resveratrol – Best Sublingual
Why it stands out: Sublingual (under the tongue) delivery bypasses the digestive system entirely, allowing NMN to enter your bloodstream directly for rapid absorption and higher bioavailability. This mimics the delivery method used in clinical research settings.
This 3-in-1 formula combines 500mg NMN with 400mg Trans-Resveratrol in lozenge form. You simply dissolve it under your tongue for 60-90 seconds rather than swallowing—the blood vessels under your tongue absorb the compounds directly into circulation. The 99% purity claim puts it among the cleanest NMN products available, and third-party testing verifies the contents match the label.
With 120 lozenges providing a 120-day supply, it’s also excellent value for a high-quality NMN product. Trans-resveratrol (the active form, not to be confused with less effective cis-resveratrol) paired with NMN mirrors the protocol popularized by longevity researcher David Sinclair, who has discussed taking a similar combination in his own routine.
The sublingual route offers a significant advantage: studies suggest oral NMN may lose up to 70% of its potency during digestion. By absorbing directly through oral mucosa, sublingual delivery can achieve much higher blood levels from the same dose. The lozenges have a mild, slightly sweet taste that most users find acceptable.
Pros:
- Sublingual delivery offers fastest and most efficient absorption
- 99% pure NMN with third-party verification
- 4-month supply per bottle offers outstanding value
- Follows Sinclair-style longevity protocols
Cons:
- Lozenges take 1-2 minutes to dissolve under tongue
- Some may not enjoy the taste or process
- Requires patience compared to simply swallowing a capsule
Best for: Biohackers who want maximum absorption and follow Sinclair-style longevity protocols, or anyone who hasn’t seen results from standard capsules.
6. NAD+ Resveratrol 61800mg Formula – Best Value
Why it stands out: With 1200mg of NAD+ per serving plus Resveratrol, Quercetin, and CoQ10 at an affordable price point, this formula offers exceptional value for a comprehensive longevity stack. You’d pay significantly more buying these ingredients separately.
This liposomal formula crams impressive dosages into each serving. The 1200mg NAD+ is supported by Resveratrol for sirtuin activation, Quercetin as a senolytic (helps clear damaged “zombie” cells that accumulate with age), and CoQ10 for mitochondrial support. The 90-count bottle provides a full month at 3 capsules daily.
What makes this formula particularly smart is the inclusion of Quercetin. Research by the Mayo Clinic and others has shown that senolytics—compounds that help clear senescent cells—can improve healthspan in animal models. Quercetin is one of the most accessible and well-studied senolytics available, and pairing it with NAD+ support addresses aging through two complementary pathways.
The formula is designed for both men and women seeking broad anti-aging coverage without buying multiple separate supplements. The liposomal delivery ensures these ingredients actually reach your cells rather than being wasted in digestion.
Pros:
- High NAD+ dose with multiple synergistic ingredients
- Liposomal delivery included
- Excellent price-to-potency ratio
- Includes quercetin for senolytic benefits
Cons:
- Requires 3 capsules daily for full dose
- Large capsule count per serving may challenge some users
- High ingredient complexity may not suit minimalists
Best for: Budget-conscious consumers who want a comprehensive longevity formula without buying multiple separate products.
7. Timeline Mitopure Powder 500mg – Best Powder Form
Why it stands out: For those who prefer mixing supplements into smoothies or beverages, this clinically-studied Urolithin A powder delivers the same benefits as the gummies in a sugar-free format. It’s the same research-backed compound in a more flexible delivery method.
Timeline’s powder form delivers 500mg of their patented Mitopure Urolithin A per serving. It mixes easily into water, juice, or protein shakes without clumping or leaving a gritty texture. The powder format allows for flexible dosing—you can take a half dose on lighter days or double up when recovering from intense exercise.
Like the gummies, it’s backed by clinical trials showing improvements in muscle strength and cellular renewal markers. The key advantage over gummies is the absence of added sugars, making it better suited for those following low-carb or keto diets, or anyone who prefers to minimize sugar intake.
Urolithin A’s mechanism is unique: rather than simply boosting NAD+ levels, it activates mitophagy—your cells’ quality control system for mitochondria. This helps clear out damaged, inefficient mitochondria so that healthy ones can take their place. Over time, this improves your overall mitochondrial function and cellular energy production.
Pros:
- Clinically validated Urolithin A from a research-backed company
- Flexible dosing with powder format
- No added sugars (unlike the gummy version)
- Mixes easily into beverages
Cons:
- Premium price point reflects clinical research investment
- Only 30 servings per container
- Less convenient than capsules or gummies for travel
Best for: Health-conscious consumers who avoid gummies and prefer mixing supplements into their morning smoothie or protein shake.
8. Sublingual NMNH 120 Count – Best NMNH Formula
Why it stands out: NMNH (dihydronicotinamide mononucleotide) is a newer, potentially more stable and effective NAD+ precursor than standard NMN. This sublingual formula maximizes absorption of this cutting-edge ingredient for early adopters who want the latest science.
NMNH is the reduced form of NMN, and early research suggests it may be more efficient at boosting NAD+ levels. The theory: NMNH is closer in structure to the end product your cells need, requiring fewer conversion steps. While more human research is needed, preliminary studies show promising results for cellular NAD+ elevation.
This formula combines NMNH with Nicotinamide Riboside, Resveratrol, and TMG (trimethylglycine) for methylation support. TMG is a thoughtful addition—when your body uses NAD+ precursors, it consumes methyl groups. Supplementing TMG helps replenish these, preventing potential depletion that could occur with long-term NAD+ supplementation.
The sublingual lozenge format ensures these ingredients bypass stomach degradation. With 120 lozenges per bottle, it provides good value for a next-generation NAD+ product. The combination of NMNH and NR also hedges your bets—if one precursor works better for your individual biochemistry, you’re covered.
Pros:
- Features newer NMNH compound with promising early research
- Sublingual delivery maximizes absorption
- Includes TMG for methylation support (often overlooked)
- Combines multiple precursors for comprehensive coverage
Cons:
- NMNH has less long-term research than NMN or NR
- Lozenges require time to dissolve
- Early adopters may pay premium for less-proven compound
Best for: Early adopters interested in the latest NAD+ precursor science who want to try the newest compounds before they become mainstream.
9. Liposomal NAD+ 1200mg with Resveratrol – Best Softgels
Why it stands out: Softgels are easier to swallow than capsules or tablets, and this liposomal formula delivers 1200mg NAD+ per serving in a vegan-friendly package. For those who struggle with large capsules, this is an ideal solution.
This formula pairs high-dose NAD+ with Trans-Resveratrol in a liposomal softgel format. The 100-softgel bottle offers excellent value for a liposomal product—compare prices with similar formulations and you’ll find this comes out favorably. Softgels tend to have better shelf stability than standard capsules because the contents are better protected from oxidation.
The vegan formula makes it accessible to plant-based consumers who want serious NAD+ support—many liposomal products use animal-derived phospholipids, but this one doesn’t. The softgels are also gentler on the stomach than standard capsules, which can be important for those who experience digestive upset from supplements.
Trans-Resveratrol is the active form of resveratrol (as opposed to cis-resveratrol, which is far less effective). Its inclusion complements the NAD+ by activating sirtuins—the longevity-associated proteins that rely on NAD+ to function properly.
Pros:
- Easy-to-swallow softgel format
- Vegan-friendly (uncommon for liposomal products)
- High potency with liposomal delivery
- Good value for 100-count bottle
Cons:
- Some prefer capsules or powders for faster dissolution
- Multiple softgels needed per serving
- Softgels may not be ideal for those who dislike gel textures
Best for: Anyone who has trouble swallowing pills or wants a vegan-friendly high-potency option that’s gentle on the stomach.
10. Luma Nutrition NAD+ 1000mg – Best Budget Option
Why it stands out: At 1000mg total (500mg per capsule), this straightforward NAD+ supplement delivers solid potency without premium pricing or unnecessary add-ons. It’s proof that effective NAD+ support doesn’t require breaking the bank.
Luma Nutrition focuses on pure NAD+ supplementation without the bells and whistles. Each bottle contains 60 capsules with 500mg per capsule, giving you flexibility in dosing—take one capsule daily for maintenance or two for a more aggressive approach. Made in the USA with GMP-certified manufacturing, it’s a reliable choice for those who want quality without complexity.
The simple formula has its advantages. For one, it’s easier to troubleshoot—if you’re building a custom supplement stack with specific dosages of Resveratrol, CoQ10, or other compounds, a pure NAD+ product lets you control exactly what you’re taking. There’s also less risk of interactions or sensitivities when you’re not dealing with multiple active ingredients.
For those new to NAD+ supplementation, this is an ideal starting point. You can assess how you respond to NAD+ support without the confounding variables of additional ingredients. If you feel benefits, great—you’ve found an affordable long-term option. If you want more, you can always upgrade to a more comprehensive formula later.
Pros:
- Affordable entry point for NAD+ supplementation
- Simple, pure formula without fillers or add-ons
- Made in USA with quality manufacturing standards
- Flexible dosing with 500mg per capsule
Cons:
- No additional synergistic ingredients (though this can be a pro)
- Standard capsule delivery (not liposomal)
- May need to add Resveratrol separately for optimal results
Best for: Beginners trying NAD+ for the first time, budget-conscious consumers who want a clean formula, or those building custom stacks who prefer single-ingredient products.
What is NAD+ and Who Should Take It?
NAD+ (nicotinamide adenine dinucleotide) is a coenzyme found in every cell of your body that’s essential for energy production, DNA repair, and cellular signaling. It acts as fuel for sirtuins—proteins that regulate aging, metabolism, and stress response. Without adequate NAD+, your mitochondria can’t efficiently convert food into cellular energy, and critical repair mechanisms slow down.
Unfortunately, NAD+ levels decline significantly as we age. Research suggests levels drop by approximately 50% between ages 40 and 60, contributing to the cellular dysfunction we experience as aging—fatigue, slower recovery, cognitive decline, and increased disease risk. This decline is why NAD+ supplementation has become central to many longevity protocols.
Most people over 35 can benefit from NAD+ support, particularly those experiencing persistent fatigue, brain fog, or slow recovery from exercise. Athletes looking to optimize performance and recovery are also good candidates, as NAD+ plays a key role in energy metabolism and muscle repair. Anyone focused on proactive longevity—rather than waiting for age-related problems to appear—may want to start earlier.
If you’re under 30 with no health concerns, your body likely produces adequate NAD+ naturally. Focus instead on the foundations: sleep, exercise, and a nutrient-dense diet. NAD+ supplementation becomes more valuable as natural production declines with age.
How to Choose the Right NAD+ Supplement
Key Ingredients to Look For
The main NAD+ precursors are NMN (nicotinamide mononucleotide), NR (nicotinamide riboside), and NMNH (dihydronicotinamide mononucleotide). NMN is the most direct precursor to NAD+ and is typically dosed at 250-500mg daily—this is what most longevity researchers take themselves. NR requires an additional conversion step but has the most published clinical research supporting its efficacy. NMNH is newer and potentially more bioavailable, though long-term data is limited.
Look for products that combine these precursors with Resveratrol (100-500mg) to activate sirtuins—the longevity genes that NAD+ powers. Trans-resveratrol is the active form; avoid products that don’t specify. Consider formulas with CoQ10 (100-200mg) for enhanced mitochondrial support, and TMG (500-1000mg) if you’re taking NAD+ precursors long-term to support methylation.
Forms Compared
Liposomal capsules and sublingual lozenges offer the best absorption since they protect ingredients from stomach acid degradation. Studies suggest standard oral NMN may lose 60-70% of its potency during digestion. Liposomal delivery encapsulates ingredients in phospholipid bubbles that pass through the digestive tract intact. Sublingual lozenges bypass digestion entirely by absorbing directly through the blood vessels under your tongue.
Standard capsules work but are the least efficient delivery method for NAD+ precursors. Powders offer flexible dosing but face similar absorption challenges. Softgels fall between standard capsules and liposomal products—they’re often easier on the stomach and have better shelf stability.
What to Avoid
Skip products with proprietary blends that hide individual ingredient dosages—you can’t verify you’re getting effective amounts. Avoid NMN or NR products stored at room temperature for extended periods, as these compounds can degrade. Look for products shipped cold or with stability guarantees.
Watch out for “free form” nicotinamide or niacin marketed as NAD+ boosters; while chemically related, they’re far less effective than NMN or NR at raising NAD+ levels and can cause uncomfortable flushing. Be skeptical of extremely low-priced NAD+ products—quality precursors are expensive to manufacture, and cheap prices often mean cheap ingredients or inadequate doses.
Side Effects and Precautions
NAD+ precursors are generally well-tolerated at recommended doses. Common side effects include mild nausea, headaches, or digestive discomfort during the first week, which typically resolve as your body adjusts to increased cellular energy production. Starting with a half dose for the first week and gradually increasing can minimize these effects. Taking supplements with food also helps reduce digestive issues.
Some users report increased energy that may interfere with sleep if taken late in the day—morning dosing is recommended for this reason. A small percentage of people experience mild flushing, particularly with products containing niacin-related compounds. This is harmless but can be uncomfortable.
Consult a healthcare provider before starting NAD+ supplements if you’re pregnant, breastfeeding, or taking medications for diabetes, as NAD+ can affect blood sugar regulation and insulin sensitivity. Those with cancer or a history of cancer should seek medical guidance, as NAD+ plays a role in cellular proliferation and the research on cancer interactions is still evolving.
While short-term safety data for NMN and NR is reassuring, there’s limited long-term human safety data on high-dose supplementation beyond 2-3 years. Moderate dosing and periodic breaks may be prudent until more research accumulates. If you experience persistent side effects, reduce your dose or try a different precursor—individual responses vary significantly.
FAQs
How much NMN or NAD+ should I take daily? Most research uses 250-500mg of NMN or NR daily, which is sufficient for most people to see benefits. Start at the lower end (250mg) and increase after 2-4 weeks if needed. Higher doses (1000mg+) are used by some biohackers but haven’t shown proportionally greater benefits in published studies. More isn’t always better—your body has limits on how quickly it can convert precursors to NAD+.
When is the best time to take NAD+ supplements? Morning is ideal since NAD+ supports energy production and circadian rhythm function. Your body’s NAD+ levels naturally fluctuate throughout the day, peaking in the morning. Taking supplements earlier amplifies this natural rhythm. Taking NAD+ precursors later in the day may cause difficulty sleeping for some users due to increased cellular energy.
How long before I notice results from NAD+ supplements? Most people report increased energy and mental clarity within 1-2 weeks of consistent use. Improvements in exercise recovery, cognitive sharpness, and overall vitality typically emerge over 4-8 weeks. More subtle benefits like improved metabolic markers or cellular health indicators may take 2-3 months to manifest and require testing to verify.
Can I take NAD+ supplements with other medications? NAD+ precursors don’t have many documented drug interactions, but they may enhance the effects of diabetes medications by improving insulin sensitivity—blood sugar monitoring is important. They’re generally safe to combine with most supplements and medications, but always inform your healthcare provider about everything you’re taking.
Is NMN or NR better for boosting NAD+ levels? Both effectively raise NAD+ levels, but they work slightly differently. NMN is the more direct precursor, converting to NAD+ in one step. NR requires two conversion steps but has more published clinical trials. Some experts recommend rotating between them or using combination products. Individual responses vary based on genetics and gut microbiome, so experimentation may be necessary.
Do NAD+ supplements actually work for anti-aging? Animal studies show compelling longevity and healthspan benefits from NAD+ boosting. Human trials demonstrate improvements in energy, muscle function, insulin sensitivity, and various metabolic markers. Long-term anti-aging effects in humans remain under investigation, but early data is promising. The strongest evidence supports benefits for energy, recovery, and cellular function rather than dramatic lifespan extension—but these quality-of-life improvements are meaningful in their own right.
Final Verdict
For most people, the Selerb NAD+ Supplements offers the best balance of NAD+ support with additional synergistic ingredients for overall vitality. If you want the strongest clinical evidence, Timeline Mitopure is the only longevity supplement with multiple peer-reviewed trials backing its specific compound.
Budget-conscious consumers should consider the Luma Nutrition NAD+ 1000mg as a clean, simple starting point. For maximum absorption, the Sublingual NMN 500mg + Resveratrol delivers NMN directly into your bloodstream and follows protocols used by leading longevity researchers.
