Best Fertility Supplements for Women (2026) – Top 10 Reviewed
Getting pregnant can take longer than expected, and the right supplements may help support your body’s natural fertility processes. From egg quality to hormone balance, targeted nutrients can make a meaningful difference.
The best fertility supplements combine research-backed ingredients like inositol, CoQ10, and folate at clinically effective dosages. Here are our top 10 picks for 2026.
Quick Comparison Table
| Product | Key Ingredients | Servings | Form | Best For |
|---|---|---|---|---|
| Zazzee Myo-Inositol | Myo-Inositol 2000mg | 60 | Capsules | Best Overall |
| ZEBORA CoQ10 400mg | CoQ10, PQQ, Omega-3 | 120 | Softgels | Best for Egg Quality |
| Ovarian Support Formula | Myo-Inositol, DIM, Folate | 30 | Capsules | Best All-in-One |
| Myo & D-Chiro Inositol Blend | Myo 2000mg + D-Chiro 50mg | 60 | Capsules | Best 40:1 Ratio |
| Needed Prenatal D3/K2 | Vitamin D3, K2 | 60 | Capsules | Best Vitamin D |
| Pink Stork Choline | Choline 550mg | 30 | Capsules | Best Choline |
| Legendairy Milk Inositol | Myo + D-Chiro 40:1 | 30 | Capsules | Best Budget Option |
| Vital Nutrients Fish Oil | EPA 400mg, DHA 300mg | 60 | Softgels | Best Omega-3 |
| Zazzee PREGNOSITOL | Myo + D-Chiro 40:1 Powder | 180 | Powder | Best Powder Formula |
| NATURELO Vitamin D3 K2 | D3 2500 IU, K2 | 60 | Capsules | Best Vegan Vitamin D |
1. Zazzee Myo-Inositol Capsules – Best Overall
Why it stands out: This is the gold standard for fertility inositol supplementation. The 2000mg dosage matches what’s used in clinical research, and Zazzee’s reputation for purity makes it a trusted choice among fertility specialists and their patients.
Myo-inositol is one of the most researched supplements for women’s reproductive health, particularly for those with PCOS or irregular cycles. Multiple clinical trials have shown it supports healthy ovulation, insulin sensitivity, and hormone balance. This formula delivers 2000mg per serving in easy-to-swallow vegan capsules made with clean, straightforward ingredients.
The dosage is optimized to work alongside d-chiro-inositol at a 40:1 ratio if you choose to add it separately—many women start with myo-inositol alone and add d-chiro based on their specific needs. Each bottle provides 60 servings, making it a two-month supply at the standard dose. Zazzee is known for rigorous third-party testing and transparent labeling, which matters when you’re planning a pregnancy.
Pros:
- Clinically studied 2000mg dosage used in research
- Vegan, kosher, and non-GMO certified
- No fillers, binders, or artificial ingredients
- Excellent value at around $0.25 per serving
Cons:
- Requires separate d-chiro supplement for optimal 40:1 ratio
- Capsules are moderately sized
Best for: Women who want a pure, high-quality myo-inositol supplement at a research-backed dose, especially those just starting fertility supplementation.
2. ZEBORA CoQ10 400mg Softgels – Best for Egg Quality
Why it stands out: CoQ10 is essential for cellular energy production, and egg cells are among the most energy-demanding cells in your body. This high-potency formula includes absorption enhancers for maximum effectiveness—critical since CoQ10 is notoriously difficult to absorb.
CoQ10 levels naturally decline with age, starting around 30 and accelerating after 35. This decline can directly impact egg quality since eggs require massive amounts of cellular energy to mature properly and support early embryo development. Research suggests that supplementing with CoQ10 can help maintain mitochondrial function in egg cells, potentially improving both egg quality and fertilization rates.
This formula delivers 400mg of CoQ10 in the ubiquinone form, plus several synergistic ingredients. PQQ (pyrroloquinoline quinone) supports the creation of new mitochondria, while omega-3 fatty acids provide additional cellular support. BioPerine black pepper extract increases CoQ10 absorption by up to 30%. The softgel format with added oils further enhances bioavailability since CoQ10 is fat-soluble.
At 120 softgels per bottle, you get a four-month supply at the standard one-per-day dosage, though some women take two daily for higher therapeutic effect during fertility treatment cycles.
Pros:
- High 400mg dosage ideal for fertility support
- Added PQQ and omega-3 for synergistic mitochondrial support
- BioPerine increases absorption significantly
- Four-month supply at standard dosage
Cons:
- Softgels contain gelatin (not suitable for vegetarians)
- Higher price point reflects premium formula
Best for: Women over 35 or anyone focused on improving egg quality, especially those preparing for IVF.
3. Ovarian Support Formula – Best All-in-One
Why it stands out: This comprehensive formula combines myo-inositol, d-chiro-inositol, DIM, and folate in one supplement. It’s designed specifically for ovarian health and hormone balance, eliminating the need to manage multiple bottles.
Instead of juggling multiple bottles and timing different supplements, this all-in-one formula covers several fertility-supporting nutrients in each serving. The myo and d-chiro inositol work together at the research-backed ratio to support healthy ovulation and blood sugar metabolism. DIM (diindolylmethane) helps with estrogen metabolism, promoting healthy hormone balance—particularly useful for women with estrogen dominance symptoms.
The added folate complex comes in active methylated form rather than synthetic folic acid, ensuring your body can use it effectively regardless of your MTHFR gene status. This matters since up to 40% of the population has gene variants that impair folic acid conversion. Each bottle provides a 30-day supply, making it easy to track your cycle alongside supplementation and reorder on a monthly schedule.
Pros:
- Multiple fertility-supporting ingredients in one convenient formula
- Includes active methylated folate (not synthetic folic acid)
- Specifically designed for reproductive and ovarian health
- Eliminates need for multiple separate supplements
Cons:
- 30-day supply requires more frequent ordering
- Higher cost per serving than single-ingredient options
Best for: Women who want comprehensive ovarian and hormone support without juggling multiple supplements.
4. Myo-Inositol & D-Chiro Inositol Blend – Best 40:1 Ratio
Why it stands out: This formula delivers the exact 40:1 ratio of myo-inositol to d-chiro-inositol that research suggests is optimal for hormone balance and ovarian function. The ratio matters because it mimics how these compounds naturally occur in healthy ovarian tissue.
The 40:1 ratio isn’t arbitrary—it reflects the natural balance found in the body and has been specifically studied for PCOS and fertility support. Too much d-chiro-inositol can actually be counterproductive for ovarian function, which is why getting the ratio right matters. This blend provides 2000mg of myo-inositol and 50mg of d-chiro-inositol per serving, matching the dosages used in clinical trials.
Clinical studies have shown this specific ratio supports insulin sensitivity, helps normalize androgen levels, and promotes regular ovulation. For women with PCOS, the combination addresses multiple aspects of the condition simultaneously. The 120-count bottle gives you a two-month supply at the recommended two-capsule-per-day dosage, making it more economical than purchasing the two forms separately.
Pros:
- Optimal 40:1 ratio in one convenient supplement
- Research-backed dosages of both inositol forms
- Two-month supply per bottle offers good value
- Specifically formulated for hormone balance
Cons:
- Four capsules needed for full daily serving
- Some women may prefer starting with myo-inositol alone
Best for: Women with PCOS, insulin resistance, or irregular cycles who need both forms of inositol at the proven ratio.
5. Needed Prenatal Vitamin D3/K2 – Best Vitamin D
Why it stands out: Formulated specifically for fertility and pregnancy by a brand that specializes in prenatal nutrition, this vitamin D supplement includes K2 for optimal calcium utilization—an often-overlooked pairing that maximizes benefits.
Vitamin D deficiency is surprisingly common and has been linked to reduced fertility, increased miscarriage risk, and complications during pregnancy. Many women are deficient without knowing it, especially those who live in northern climates, have darker skin, or spend most of their time indoors. Getting your vitamin D levels tested and optimized before conception is one of the simplest fertility interventions available.
This formula from Needed, a brand built by nutrition experts specifically for the preconception-to-postpartum journey, delivers vitamin D3 paired with K2. The K2 ensures calcium goes to your bones rather than accumulating in soft tissues, supporting both your bone health and your future baby’s skeletal development. The combination also supports immune function, which becomes increasingly important during early pregnancy when your immune system undergoes significant changes.
The 60-capsule bottle provides a two-month supply at one capsule daily, though some women need higher doses based on their blood levels.
Pros:
- Designed specifically for fertility, pregnancy, and postpartum
- Includes vitamin K2 for synergistic calcium and bone support
- Third-party tested for purity and potency
- Clean ingredients with no unnecessary additives
Cons:
- Premium pricing compared to basic vitamin D supplements
- May need additional D3 if blood levels are very low
Best for: Women actively trying to conceive who want a prenatal-focused vitamin D supplement from a trusted specialist brand.
6. Pink Stork Choline – Best Choline
Why it stands out: Choline is critical for fetal brain development but often completely missing from prenatal vitamins. This formula delivers the full 550mg daily recommended intake from a highly bioavailable, patented source.
Choline is one of the most underrated prenatal nutrients. Research shows adequate choline intake during conception and early pregnancy supports neural tube closure, fetal brain development, and may even have long-term effects on the child’s cognitive function. Yet most women don’t get enough from diet alone (the main sources are eggs and liver), and many prenatal vitamins contain little to none.
This supplement provides the full recommended daily intake from VitaCholine, a patented form of choline bitartrate known for superior quality and bioavailability. Pink Stork formulated this specifically for pregnant and postpartum women, and it’s been designed to complement their prenatal vitamin line. The one-capsule-per-day dosing makes compliance easy, even when you’re already taking multiple supplements.
Starting choline supplementation during preconception ensures your levels are optimal from day one of pregnancy, which is crucial since neural tube development happens in the first weeks—often before you even know you’re pregnant.
Pros:
- Full daily recommended intake (550mg) in one capsule
- VitaCholine patented form for superior bioavailability
- Simple one-capsule daily dosing
- From a trusted women’s health brand
Cons:
- Only 30-day supply per bottle
- Single ingredient (by design, but requires separate prenatal)
Best for: Women in preconception or early pregnancy who need to supplement choline to support fetal brain development.
7. Legendairy Milk Pure Inositol – Best Budget Option
Why it stands out: This affordable option delivers the proven 40:1 inositol ratio at a lower price point than premium competitors, making long-term supplementation more accessible without sacrificing quality.
From Legendairy Milk, a brand that built its reputation on evidence-based breastfeeding support products, this inositol formula provides both myo and d-chiro forms at the optimal 40:1 ratio. The brand’s focus on women’s health means this isn’t just a generic inositol supplement—it’s specifically designed for ovarian and fertility support with clean ingredients and straightforward dosing.
While it may lack some of the extras found in premium formulas (like added DIM or folate), it delivers the core inositol benefits that most women need. This makes it an excellent choice for women who are already taking a comprehensive prenatal vitamin and just need targeted inositol support. The 30-day supply keeps initial investment low while you assess how your body responds.
The brand’s transparency about ingredients and manufacturing standards provides peace of mind, and their customer service team is known for being responsive to questions about their products.
Pros:
- Affordable 40:1 ratio formula with proven dosages
- Clean ingredients without unnecessary fillers
- From a trusted women’s health brand
- Good starting point for inositol supplementation
Cons:
- Fewer additional ingredients than premium all-in-one options
- 30-day supply requires monthly reordering
Best for: Budget-conscious women who want effective inositol supplementation at the optimal ratio without premium pricing.
8. Vital Nutrients Ultra Pure Fish Oil – Best Omega-3
Why it stands out: This pharmaceutical-grade fish oil delivers high EPA and DHA in a sustainably sourced, rigorously tested formula—the kind of quality that matters when you’re planning a pregnancy and want to avoid contaminants.
Omega-3 fatty acids, particularly DHA, are essential building blocks for your baby’s brain, eyes, and nervous system. They also support healthy inflammation response in your own body, which plays a role in implantation and early pregnancy maintenance. Research consistently shows that women with higher omega-3 levels have better fertility outcomes and lower rates of preterm birth.
This formula from Vital Nutrients, a professional-grade supplement company, provides 400mg EPA and 300mg DHA per serving from sustainably sourced fish. Every batch undergoes third-party testing for heavy metals, PCBs, dioxins, and other contaminants—critical quality assurance since fish oil can concentrate toxins if not properly processed and tested.
The lemon flavoring minimizes the fishy aftertaste and “fish burps” that plague many omega-3 supplements. The softgels are also smaller than many fish oil supplements, making them easier to swallow alongside your other preconception supplements. The 60-softgel bottle provides a one-month supply at the two-per-day recommended serving.
Pros:
- Pharmaceutical-grade quality with rigorous testing
- Sustainably sourced fish oil
- Third-party tested for heavy metals, PCBs, and contaminants
- Pleasant lemon flavor reduces fishy aftertaste
Cons:
- Premium price reflects professional-grade quality
- Two softgels needed for full daily serving
Best for: Women who want the highest-quality omega-3 supplement for preconception and pregnancy, especially those concerned about purity and sustainability.
9. Zazzee PREGNOSITOL Powder – Best Powder Formula
Why it stands out: This powder format allows precise dosing and easy mixing, ideal for women who struggle with swallowing pills or want to customize their intake. The six-month supply offers unbeatable value for long-term supplementation.
PREGNOSITOL provides the proven 40:1 ratio of myo-inositol to d-chiro-inositol in an unflavored powder that mixes easily into water, juice, or smoothies. The name reflects its specific formulation for preconception and pregnancy support. The included measuring scoop ensures accurate dosing every time—important since inositol effectiveness depends on hitting the right therapeutic dose.
The six-month supply makes this the most economical option for women committed to long-term inositol supplementation. At roughly $0.10 per serving, it costs a fraction of capsule formulas while delivering identical therapeutic benefits. The powder format also allows you to split doses throughout the day, which some women prefer for steady blood levels and better digestive tolerance.
The unflavored powder has a slightly sweet taste (inositol is naturally sweet) and dissolves completely without grittiness. Many women simply add it to their morning water or mix it into a protein shake as part of their daily routine.
Pros:
- Outstanding six-month supply at exceptional value
- Easy to mix into water, smoothies, or other beverages
- Allows flexible, customized dosing throughout the day
- Unflavored with naturally pleasant, slightly sweet taste
Cons:
- Requires mixing (less convenient than grab-and-go capsules)
- Need to remember to take with liquids
Best for: Women who prefer powders over pills, want the best value on inositol supplementation, or like to customize their daily dosing.
10. NATURELO Vitamin D3 K2 – Best Vegan Vitamin D
Why it stands out: This plant-based vitamin D3 comes from lichen rather than the typical sheep’s wool lanolin source, making it suitable for vegans and vegetarians while still delivering the superior D3 form that the body uses most efficiently.
Most vitamin D3 supplements are derived from lanolin, a waxy substance from sheep’s wool. While effective, this source doesn’t work for vegans or those who prefer to avoid animal products. NATURELO solved this by sourcing their D3 from lichen, a plant-based organism that naturally produces vitamin D3—giving you all the benefits without compromising your dietary principles.
The 2500 IU D3 combined with vitamin K2 supports bone health, immune function, and fertility. Vitamin D receptors are found throughout the reproductive system, and adequate levels are associated with better IVF outcomes, healthier pregnancies, and reduced risk of complications. The K2 ensures proper calcium metabolism, directing calcium to bones rather than soft tissues.
NATURELO’s whole-food approach aligns with clean eating principles, and the formula is certified free from GMOs, gluten, soy, and other common allergens. The 60-capsule bottle provides a two-month supply at one capsule daily, though some women may need higher doses based on their blood levels and healthcare provider recommendations.
Pros:
- 100% plant-based vitamin D3 suitable for vegans
- Includes K2 for optimal calcium absorption and bone health
- Non-GMO and free from common allergens
- Clean, whole-food approach to supplementation
Cons:
- 2500 IU may not be sufficient to correct severe deficiency
- Premium pricing for plant-based sourcing
Best for: Vegan or vegetarian women who need vitamin D support for fertility and prefer plant-based supplements.
What is Fertility Supplementation and Who Should Consider It?
Fertility supplements provide targeted nutrients that support reproductive health, hormone balance, and egg quality. They work by filling nutritional gaps that can impact conception and early pregnancy, supporting the complex biological processes involved in ovulation, fertilization, and implantation.
Women who may benefit most include those with PCOS or irregular cycles (where inositol has strong research support), anyone over 35 trying to conceive (CoQ10 becomes increasingly important), women with known nutrient deficiencies (particularly vitamin D, which is common), and those who’ve been trying to conceive for six months or longer without success.
Even with a healthy diet, certain nutrients are difficult to obtain in therapeutic amounts from food alone. For example, you’d need to eat approximately 20 eggs daily to get the myo-inositol dosage used in fertility studies. Similarly, CoQ10 from food sources is measured in milligrams while supplement doses are in hundreds of milligrams. Fertility supplementation bridges this gap between what food provides and what may optimize reproductive function.
How to Choose the Right Fertility Supplement
Key Ingredients to Look For
The most research-backed fertility supplements include myo-inositol (2000-4000mg daily) for ovulation support and insulin sensitivity, CoQ10 (200-600mg daily) for egg quality and mitochondrial function, vitamin D3 (2000-5000 IU daily depending on your blood levels) for hormone regulation and immune support, folate in the methylated form like methylfolate or folinic acid (400-800mcg) for neural tube development, omega-3s (at least 200mg DHA, ideally 300-500mg) for fetal brain development, and choline (450-550mg) which most prenatals lack.
If you have PCOS or insulin resistance, the 40:1 ratio of myo-inositol to d-chiro-inositol becomes particularly important. For women over 35 or those with diminished ovarian reserve, prioritizing CoQ10 at higher doses (400-600mg) may provide additional benefit for egg quality.
Forms Compared
Capsules offer convenience and precise dosing, making them ideal for busy lifestyles. Softgels work best for fat-soluble nutrients like CoQ10 and omega-3s since they include oils that enhance absorption—look for these forms when choosing these specific supplements. Powders provide flexibility in dosing and work well for those who dislike swallowing pills or want to split doses throughout the day. For inositol specifically, both capsules and powder are equally effective, so choose based on your preference.
What to Avoid
Skip supplements with synthetic folic acid if you have MTHFR gene variants—approximately 40% of the population has some form of this common genetic variation that impairs folic acid conversion. Look for methylfolate (also labeled as 5-MTHF, L-methylfolate, or Metafolin) instead. Avoid formulas with artificial colors, flavors, or unnecessary fillers that add nothing to the supplement’s effectiveness.
Be wary of proprietary blends that don’t disclose individual ingredient amounts—you can’t verify you’re getting therapeutic doses. For fish oil, ensure third-party testing for mercury, PCBs, and other contaminants is documented. And be skeptical of supplements making dramatic fertility claims without research to back them up.
Side Effects and Precautions
Most fertility supplements are well-tolerated when taken at recommended doses. Inositol may cause mild digestive upset initially—symptoms like bloating or loose stools—which typically resolves within a week or two as your body adjusts. Starting with a lower dose and gradually increasing can help minimize this transition period. CoQ10 can occasionally cause insomnia or restlessness if taken late in the day, so morning dosing is generally recommended. High-dose fish oil may cause fishy burps, mild nausea, or loose stools, which improves significantly by taking capsules with food or choosing enteric-coated formulas.
Consult your healthcare provider before starting any supplement regimen, particularly if you’re taking medications (blood thinners can interact with omega-3s and CoQ10), have thyroid conditions (some supplements can affect thyroid function), or are already undergoing fertility treatments. Some supplements may need dose adjustments during IVF cycles—for example, some fertility specialists recommend stopping certain supplements before egg retrieval. Women with hormone-sensitive conditions should discuss DIM and other hormone-modulating supplements with their doctor before use.
FAQs
How long should I take fertility supplements before trying to conceive? Most experts recommend starting fertility supplements at least three months before actively trying to conceive. This timeframe allows nutrients like CoQ10 to improve egg quality, as eggs take about 90 days to mature.
Can I take multiple fertility supplements together? Yes, most fertility supplements can be combined safely. In fact, a combination approach (inositol + CoQ10 + vitamin D + omega-3s + folate) often works better than any single supplement. However, watch for overlap in comprehensive formulas to avoid mega-dosing.
When is the best time to take fertility supplements? Inositol is often taken twice daily (morning and evening) for steady levels. CoQ10 is best taken with a fat-containing meal for absorption, and earlier in the day to avoid sleep disruption. Fat-soluble vitamins (D, omega-3s) should be taken with food containing fat.
Are there any supplements I should stop when I get a positive pregnancy test? Most fertility supplements are safe to continue into pregnancy, but check with your doctor. CoQ10 is generally discontinued after the first trimester. Continue prenatal vitamins, omega-3s, vitamin D, and choline throughout pregnancy.
Do fertility supplements help with IVF success? Some studies suggest CoQ10 and DHEA (under medical supervision) may improve IVF outcomes, particularly in women with diminished ovarian reserve. Inositol has shown benefits for women with PCOS undergoing fertility treatments. Always discuss supplementation with your fertility specialist before an IVF cycle.
How do I know if fertility supplements are working? Improvements in cycle regularity, ovulation signs (like cervical mucus changes), and reduced PMS symptoms can indicate the supplements are having an effect. For egg quality improvements, the evidence is typically seen in fertility treatment outcomes rather than obvious physical signs.
Final Verdict
For most women, Zazzee Myo-Inositol is the best starting point—it’s backed by solid research, reasonably priced, and addresses one of the most common fertility issues. Add ZEBORA CoQ10 if you’re over 35 or concerned about egg quality.
For a budget-friendly option, Legendairy Milk Pure Inositol delivers the key benefits at a lower cost. If you want comprehensive support in one bottle, the Ovarian Support Formula combines multiple fertility-supporting ingredients.
Whatever you choose, consistency matters most. Give supplements at least three months to make a difference, and work with your healthcare provider to optimize your fertility support plan.
