Best Licorice Root Supplements (2026) – Top 10 Reviewed
Licorice root has been a cornerstone of traditional medicine for thousands of years, prized for its ability to soothe digestive discomfort, support respiratory health, and promote overall wellness. Whether you’re looking for whole-root capsules or the gentler DGL (deglycyrrhizinated licorice) form, finding a quality supplement makes all the difference.
The best licorice root supplements use properly extracted ingredients, provide clinically relevant doses, and clearly state whether glycyrrhizin has been removed. Here are our top 10 picks for 2026.
| Product | Key Ingredients | Servings | Form | Best For |
|---|---|---|---|---|
| Zazzee Organic DGL Licorice | 7000mg DGL (20:1 extract) | 120 | Capsules | Best Overall |
| Nature’s Way Licorice Root | 900mg whole root | 50 | Capsules | Best Traditional Formula |
| Natural Factors DGL Chewable | 400mg DGL + anise | 180 | Chewable | Best Chewable |
| NOW Foods Licorice Root | 450mg whole root | 100 | Capsules | Best Budget |
| Pure Encapsulations DGL Plus | 300mg DGL + marshmallow, aloe | 60 | Capsules | Best Premium Blend |
| Nature’s Way DGL Ultra | 75mg GutGard DGL | 90 | Capsules | Best Clinically Studied |
| Integrative Therapeutics Rhizinate | 760mg DGL (3:1 extract) | 33 | Chewable | Best for Digestive Relief |
| Nutricost DGL | 500mg DGL (5000mg equivalent) | 120 | Capsules | Best Value |
| Horbaach DGL Chewable | 4000mg DGL | 180 | Chewable | Best High-Potency Chewable |
| Wild & Organic Licorice Tincture | Licorice root extract | ~60 | Liquid | Best Liquid Form |
1. Zazzee USDA Organic DGL Licorice – Best Overall
Why it stands out: This is one of the most potent DGL supplements available, delivering 7000mg strength from a concentrated 20:1 extract. The USDA organic certification ensures purity without pesticide residues or chemical fillers—and Zazzee goes the extra mile by using organic ingredients even in their capsules.
Zazzee uses 100% USDA organic ingredients throughout—including the pullulan vegetarian capsules, rice powder, and rice hulls—which is exceptionally rare in the supplement industry. Most brands cut corners on inactive ingredients, but Zazzee maintains organic integrity from start to finish. Each bottle provides a 4-month supply at one capsule daily, making it economical despite the premium organic certification.
The DGL formulation removes glycyrrhizin through a careful extraction process, making it safe for long-term daily use without the blood pressure and potassium concerns associated with whole licorice root. This is particularly important for those who want ongoing digestive support rather than short-term use. Third-party testing verifies potency and purity, and the product is manufactured in an FDA-certified facility in the USA under strict GMP standards.
The 20:1 extract ratio means each capsule contains the equivalent of 7000mg of whole licorice root in concentrated form. This high potency means you only need one capsule daily, rather than the 2-3 capsules required by many competitors. Zazzee backs their product with a lifetime money-back guarantee, showing confidence in their formulation.
Pros:
- USDA organic certified (including capsules)
- Potent 20:1 extract ratio
- 4-month supply per bottle
- Glycyrrhizin removed for safety
- Made in USA with third-party testing
Cons:
- Higher upfront cost than non-organic options
Best for: Those wanting the strongest organic DGL available with maximum safety for daily use.
2. Nature’s Way Licorice Root – Best Traditional Formula
Why it stands out: Nature’s Way delivers whole licorice root at 900mg per serving, preserving all the plant’s natural compounds including glycyrrhizin for traditional benefits. The Non-GMO Project verification adds quality assurance.
This is the go-to choice for those who want full-spectrum licorice root rather than the deglycyrrhizinated form. Nature’s Way has been making herbal supplements for over 50 years, and their licorice root capsules use traditional extraction methods. The vegetarian capsules are easy to swallow, and the bottles are made from 97% post-consumer recycled plastic. Note that whole licorice root is best used short-term due to glycyrrhizin content.
Pros:
- Full-spectrum whole root formula
- Non-GMO Project Verified
- Trusted brand with 50+ year history
- Sustainable packaging
Cons:
- Contains glycyrrhizin (not for long-term use)
Best for: Those seeking traditional whole licorice root benefits for short-term use.
3. Natural Factors DGL Chewable – Best Chewable
Why it stands out: These sugar-free chewable tablets combine 400mg DGL with anise seed for a pleasant taste while supporting the stomach’s protective mucosal lining. The formula is specifically designed to chew before meals for optimal effect—the way clinical research suggests DGL works best.
Natural Factors is a family-owned B-Corp with direct ownership of all manufacturing stages—from their own organic farms in British Columbia to the finished product. This vertical integration ensures quality control at every step, which is unusual in the supplement industry where most companies rely on contract manufacturers. Their DGL chewables are formulated to support the integrity of the stomach and intestinal wall without the side effects of glycyrrhizin.
The addition of anise seed powder (55mg per tablet) serves a dual purpose: it creates a pleasant licorice-like taste that makes the tablets enjoyable to chew, and anise has its own traditional use for digestive comfort. A touch of stevia provides sweetness without sugar. The formula is free from dairy, wheat, gluten, yeast, soy, egg, fish, shellfish, salt, tree nuts, and GMOs—making it suitable for those with multiple food sensitivities.
Chewing DGL before meals allows it to mix with saliva for faster action on the gastric mucosa. Research suggests this pre-meal timing may enhance the protective coating effects on the stomach lining. Take 1 tablet 1-3 times daily, 20 minutes before each meal. Natural Factors is also carbon neutral and certified B-Corp, appealing to environmentally conscious consumers.
Pros:
- Pleasant taste with anise seed
- Sugar-free formula
- B-Corp certified, carbon neutral company
- 180 tablets per bottle
- Extensive allergen-free formulation
Cons:
- Must remember to chew before meals
Best for: Those who prefer chewables and want to take DGL the clinically-recommended way (before meals).
4. NOW Foods Licorice Root – Best Budget
Why it stands out: NOW Foods delivers quality whole licorice root at 450mg per capsule at a price point that’s hard to beat. The GMP-certified manufacturing ensures consistent quality despite the affordable cost.
NOW Foods has been a leader in affordable natural supplements since 1968. Their licorice root capsules provide the traditional herb used in Chinese medicine for thousands of years. The formula is free from common allergens including wheat, gluten, soy, milk, egg, fish, and tree nuts. At just 2 capsules daily, a single bottle lasts up to 50 days. The vegetarian capsules use cellulose and vegetable-source stearic acid.
Pros:
- Excellent price per serving
- Free from major allergens
- GMP-certified facility
- Family-owned company since 1968
Cons:
- Contains glycyrrhizin (monitor blood pressure with long-term use)
Best for: Budget-conscious buyers wanting quality whole licorice root.
5. Pure Encapsulations DGL Plus – Best Premium Blend
Why it stands out: This practitioner-grade formula combines DGL with marshmallow root, aloe vera, and slippery elm bark for comprehensive GI tract support. Pure Encapsulations is known for hypoallergenic formulas free from unnecessary additives—the brand that functional medicine doctors recommend most.
Pure Encapsulations sets the gold standard for clean supplements—their products contain no wheat, gluten, egg, peanut, trans fats, artificial colors, artificial flavors, or artificial sweeteners. This commitment to purity makes them a favorite among practitioners treating patients with multiple chemical sensitivities. The DGL Plus formula works synergistically: DGL supports the stomach lining by stimulating protective mucus production, marshmallow root provides soothing mucilage that coats irritated tissues, aloe vera supports gut healing with its anti-inflammatory compounds, and slippery elm forms a protective gel-like coating.
Each capsule delivers 300mg of deglycyrrhizinated licorice extract alongside 150mg marshmallow root, 50mg aloe vera extract, and 100mg slippery elm bark. This multi-herb approach addresses digestive comfort from multiple angles—something you won’t get from DGL alone. The combination is particularly well-suited for those dealing with occasional heartburn, stomach upset, or general digestive sensitivity.
Pure Encapsulations manufactures in a facility that exceeds GMP standards with rigorous quality testing. Each raw material is tested for identity, potency, and contaminants. The capsules are vegetarian and the formula is non-GMO verified. Take 1-3 capsules daily before meals, or as directed by your healthcare practitioner.
Pros:
- Synergistic 4-ingredient formula
- Hypoallergenic and ultra-pure
- Practitioner recommended
- Third-party tested
- No common allergens or additives
Cons:
- Premium price point
- Only 60 capsules per bottle
Best for: Those wanting comprehensive gut support from a premium, hypoallergenic brand.
6. Nature’s Way DGL Ultra – Best Clinically Studied
Why it stands out: This formula uses GutGard, a clinically studied DGL extract that has been shown in human trials to support digestive comfort. The 75mg per capsule is specifically calibrated based on research.
GutGard is a patented DGL extract that has undergone multiple clinical studies examining its effects on digestive wellness. Unlike generic DGL, GutGard has published research supporting its use. Nature’s Way DGL Ultra provides this standardized extract in convenient capsule form—take one after food in the morning and one after food in the evening. The formula is vegan, gluten-free, and contains less than 1% glycyrrhizin.
Pros:
- Uses patented GutGard extract
- Backed by clinical research
- Vegan and gluten-free
- Precise, research-based dosing
Cons:
- Lower mg amount (though more concentrated)
Best for: Those who want a DGL backed by published clinical research.
7. Integrative Therapeutics Rhizinate – Best for Digestive Relief
Why it stands out: Rhizinate has been a practitioner favorite for decades, providing 760mg of 3:1 DGL extract in a chewable form specifically designed for fast-acting stomach relief. The formula contains less than 1% glycyrrhizin and has been recommended by naturopathic physicians since the 1990s.
Integrative Therapeutics creates supplements used by naturopathic physicians, chiropractors, and integrative medicine practitioners. The company focuses exclusively on practitioner channels, which means their formulas are designed for clinical effectiveness rather than mass-market appeal. Rhizinate works by stimulating the natural protective factors in the digestive tract—specifically supporting the mucin barrier that protects the stomach lining from acid.
The chewable format is central to Rhizinate’s effectiveness. When you chew the tablet, DGL mixes with saliva and begins coating the esophagus and stomach before you even swallow. Research suggests this extended contact time enhances DGL’s protective effects. The added glycine (100mg per serving) provides an additional amino acid that supports stomach lining health. The anise seed powder creates a pleasant licorice flavor that most users enjoy.
For best results, chew 2 tablets twenty minutes before each meal—timing that allows the DGL to coat the stomach before food arrives. Many users report noticeable relief from occasional heartburn, stomach discomfort, and digestive sensitivity within days. The formula contains no wheat, gluten, soy, dairy, or artificial colors or preservatives.
Pros:
- Professional-grade formula
- Fast-acting chewable format
- Added glycine for enhanced support
- 25+ year track record
- Less than 1% glycyrrhizin
Cons:
- Must be chewed before meals for best results
- 33 servings per bottle (at recommended dose)
Best for: Those seeking practitioner-recommended DGL for occasional stomach discomfort.
8. Nutricost DGL – Best Value
Why it stands out: Nutricost delivers 500mg of DGL extract (equivalent to 5000mg licorice root) in 120 servings at one of the lowest costs per serving available. No-frills quality at a wallet-friendly price.
Nutricost has built a reputation for straightforward supplements without markup for fancy marketing. Their DGL capsules provide a 10:1 extract ratio, meaning each 500mg capsule delivers the equivalent of 5000mg of whole licorice root—but with the glycyrrhizin removed. The formula is non-GMO, vegan, and gluten-free. At 120 capsules per bottle and one capsule per serving, this is a 4-month supply for most users.
Pros:
- Excellent cost per serving
- 10:1 concentrated extract
- Non-GMO and vegan
- 120-day supply
Cons:
- Basic packaging and branding
- No additional supportive ingredients
Best for: Value-seekers who want effective DGL without premium pricing.
9. Horbaach DGL Chewable – Best High-Potency Chewable
Why it stands out: At 4000mg per serving, these are among the highest-potency DGL chewables available. The 180-count bottle provides excellent value for those who need stronger digestive support.
Horbaach specializes in high-potency supplements, and their DGL chewables deliver. The deglycyrrhizinated licorice root extract provides digestive support without the glycyrrhizin-related concerns of whole licorice. The vegetarian tablets have a pleasant taste and chew easily. The large 180-count bottle means you won’t run out quickly, even at the higher potency. Free from gluten, wheat, yeast, lactose, soy, and artificial ingredients.
Pros:
- High 4000mg potency
- 180 tablets per bottle
- Free from common allergens
- Pleasant taste
Cons:
- Chewables may not suit everyone’s preference
- Larger tablet size
Best for: Those who want maximum-strength DGL in chewable form.
10. Wild & Organic Licorice Root Tincture – Best Liquid Form
Why it stands out: This liquid extract offers fast absorption and flexible dosing for those who prefer not to swallow capsules. The alcohol-free, sugar-free formula supports digestive, lung, and skin health.
Liquid tinctures provide an alternative delivery method that some people find more effective than capsules. Wild & Organic’s licorice root tincture uses traditional extraction methods to preserve the full spectrum of beneficial compounds. The dropper allows precise dose adjustments—start with a smaller amount and increase as needed. The formula is vegan and made without added sugars or artificial preservatives. Note that this is whole licorice root, not DGL.
Pros:
- Fast-absorbing liquid format
- Flexible, adjustable dosing
- Alcohol-free and sugar-free
- Supports multiple body systems
Cons:
- Contains glycyrrhizin (not for long-term daily use)
- Stronger taste than capsules
Best for: Those who prefer liquid supplements or need flexible dosing options.
What is Licorice Root and Who Should Take It?
Licorice root (Glycyrrhiza glabra) contains over 300 bioactive compounds including glycyrrhizin (the sweet-tasting compound responsible for licorice’s characteristic flavor), flavonoids, isoflavonoids, and various polysaccharides that contribute to its therapeutic effects. The name “glycyrrhiza” literally means “sweet root” in Greek—licorice is approximately 50 times sweeter than sugar. The root has been used in traditional Chinese and Ayurvedic medicine for millennia to support digestive health, respiratory function, and overall vitality.
Modern research has examined licorice root’s potential for multiple applications. Studies suggest it may help soothe stomach discomfort by increasing mucus production in the digestive tract, creating a protective barrier against stomach acid. The anti-inflammatory compounds in licorice have been studied for respiratory support, helping to ease occasional coughs and throat irritation. Some research has also explored licorice’s potential for supporting adrenal function, skin health, and even liver protection.
Those who may benefit from licorice root include people experiencing occasional digestive discomfort like heartburn or upset stomach, those seeking respiratory support for seasonal challenges, individuals looking for traditional herbal wellness support, and those interested in the adaptogenic properties some herbalists attribute to licorice. The root is also popular among practitioners of traditional Chinese medicine, where it’s considered a “harmonizing” herb often combined with other botanicals.
However, the glycyrrhizin in whole licorice root can raise blood pressure and lower potassium levels with long-term or high-dose use. This occurs because glycyrrhizin affects cortisol metabolism, causing the body to retain sodium and excrete potassium. This is why DGL (deglycyrrhizinated licorice) supplements exist as a safer alternative for daily use—the glycyrrhizin removal process eliminates these concerns while preserving DGL’s digestive benefits.
How to Choose the Right Licorice Root Supplement
DGL vs. Whole Licorice Root
The most important decision is whether you need DGL or whole licorice root. DGL (deglycyrrhizinated licorice) has the glycyrrhizin removed through a specialized extraction process, making it safe for long-term daily use and ideal for digestive support. Without glycyrrhizin, DGL doesn’t affect blood pressure or potassium levels, so it can be taken indefinitely for ongoing gut lining support. Most research on licorice for digestive health has used DGL specifically.
Whole licorice root retains all compounds including glycyrrhizin, which provides additional benefits but should only be used short-term—typically 4-6 weeks maximum—unless under practitioner guidance. Some people prefer whole licorice root for its traditional uses like respiratory support or adrenal function, where glycyrrhizin may play a beneficial role. However, even short-term whole licorice use requires monitoring blood pressure, especially in those with hypertension.
For digestive health and gut lining support, DGL is generally the better choice. Clinical studies examining licorice for stomach comfort, heartburn, and ulcer support have primarily used DGL. For traditional uses where glycyrrhizin’s effects are desired—such as adrenal support during stress or respiratory relief—whole licorice root may be preferred for short-term, supervised use.
Forms: Capsules, Chewables, Powders, Liquids
Capsules offer convenience, precise dosing, and no taste concerns. They’re ideal for those who don’t want to taste licorice and prefer straightforward supplementation. Most DGL capsules can be taken with or without food, though timing may vary by product.
Chewables are specifically recommended for DGL because mixing with saliva before swallowing may enhance effectiveness. Research suggests that DGL works in part by stimulating local protective factors in the digestive tract—chewing extends contact time and allows the DGL to begin working in the mouth and esophagus. If using DGL for stomach or esophageal support, chewables taken 20 minutes before meals are often the preferred form.
Powders provide flexibility for those who want to adjust doses or add licorice to smoothies, teas, or other beverages. DGL powder can be mixed with water and swished in the mouth before swallowing, mimicking the chewable effect. Powders are also economical since you’re not paying for capsule materials.
Liquid tinctures offer fast absorption and work well for those who dislike swallowing pills. Tinctures allow precise dose adjustments with a dropper. Most liquid licorice extracts are whole licorice root (not DGL), so the same glycyrrhizin cautions apply.
What to Look For
Choose supplements from reputable manufacturers with third-party testing, GMP certification, and clear labeling of ingredient amounts and extract ratios. For DGL, look for products that specify glycyrrhizin content is below 1-3%—this confirms adequate removal. Extract ratios like 10:1 or 20:1 indicate concentration strength (a 20:1 extract means 20 pounds of raw licorice were concentrated into 1 pound of extract).
Organic certification is valuable for avoiding pesticide residues, particularly for daily-use supplements. USDA organic is the gold standard in the United States. Look for products free from unnecessary fillers, artificial colors, or sweeteners—especially if you have food sensitivities. Many quality DGL supplements are also free from common allergens like gluten, dairy, soy, and eggs.
For chewables, check the sweetener used. Quality products use xylitol, stevia, or small amounts of fructose rather than high-fructose corn syrup or artificial sweeteners. The inactive ingredients matter almost as much as the active ones for daily-use supplements.
Side Effects and Precautions
Whole licorice root containing glycyrrhizin can cause serious side effects when used long-term or in high doses. The most common concern is elevated blood pressure (hypertension), which occurs because glycyrrhizin inhibits an enzyme involved in cortisol metabolism. This leads to increased cortisol activity, causing the body to retain sodium and water while excreting potassium. The result can include fluid retention, swelling, headaches, and potentially dangerous blood pressure elevation.
Low potassium levels (hypokalemia) from long-term licorice use can cause muscle weakness, cramping, fatigue, and in severe cases, heart rhythm abnormalities. The World Health Organization recommends limiting glycyrrhizin intake to no more than 100mg per day, and most health authorities suggest that whole licorice root should not be used for more than 4-6 weeks without medical supervision.
DGL supplements have the glycyrrhizin removed and are generally well-tolerated for extended use. Because the problematic compound has been extracted, DGL doesn’t carry the same blood pressure or potassium concerns. Some people may experience mild digestive symptoms initially as the gut adjusts—typically temporary and mild. DGL is considered safe for long-term daily use in most adults.
Those with high blood pressure, heart disease, kidney disease, or existing low potassium should avoid whole licorice root entirely and consult a healthcare provider before using even DGL. Pregnant and nursing women should not use any licorice root supplements—some research suggests glycyrrhizin may affect fetal development, and there isn’t sufficient safety data for DGL during pregnancy.
Licorice can interact with certain medications. It may reduce the effectiveness of blood pressure medications while enhancing potassium loss from diuretics—a potentially dangerous combination. Licorice can also interact with blood thinners (warfarin), corticosteroids, heart medications including digoxin, and hormonal therapies including birth control pills. Always consult your healthcare provider before starting licorice supplements if you take any prescription medications.
FAQs
What’s the difference between DGL and regular licorice root?
DGL (deglycyrrhizinated licorice) has the glycyrrhizin compound removed, eliminating the risk of blood pressure elevation and potassium depletion. This makes DGL safe for long-term daily use. Regular licorice root retains glycyrrhizin, which provides certain traditional benefits but limits safe usage to short periods.
How long does it take for licorice root supplements to work?
For digestive support, many people notice effects within 1-2 weeks of consistent use. DGL chewables taken before meals may provide more immediate soothing effects. Full benefits for gut lining support typically develop over 4-8 weeks of regular use.
Should I take licorice root with food or on an empty stomach?
DGL chewables are specifically designed to be taken 20 minutes before meals for optimal effect on the stomach lining. Whole licorice root capsules are typically taken with food to reduce the chance of stomach upset. Always follow the specific directions on your chosen product.
Can I take licorice root every day?
DGL supplements can safely be taken daily for extended periods since the glycyrrhizin has been removed. Whole licorice root containing glycyrrhizin should generally be limited to 4-6 weeks of continuous use, followed by a break, unless directed otherwise by a healthcare provider.
Does licorice root interact with any medications?
Yes, licorice root (especially forms containing glycyrrhizin) can interact with blood pressure medications, diuretics, blood thinners (warfarin), corticosteroids, and heart medications. If you take any prescription medications, consult your healthcare provider before starting licorice root supplements.
Is licorice root safe during pregnancy?
No, licorice root supplements should be avoided during pregnancy and breastfeeding. Some research suggests glycyrrhizin may affect fetal development, and there is insufficient safety data for DGL during pregnancy. Consult your healthcare provider for alternatives.
Final Verdict
Zazzee USDA Organic DGL Licorice takes the top spot for its combination of potency, purity, and safety—the 7000mg strength from a 20:1 organic extract delivers serious digestive support without glycyrrhizin concerns. The 4-month supply makes it economical despite the premium certification, and the complete organic formulation (including capsules) sets it apart from competitors.
For budget-conscious buyers, Nutricost DGL provides excellent value with a concentrated 10:1 extract at a fraction of the cost—you get 120 servings of effective DGL without paying for fancy branding. If you prefer chewables, Natural Factors DGL Chewable offers the clinically-recommended pre-meal format with pleasant anise flavor and the backing of a carbon-neutral B-Corp company.
Those seeking a clinically-studied option should consider Nature’s Way DGL Ultra with its patented GutGard extract backed by published human research. For comprehensive gut support beyond DGL alone, Pure Encapsulations DGL Plus combines deglycyrrhizinated licorice with marshmallow root, aloe vera, and slippery elm in a practitioner-trusted hypoallergenic formula.
If you want traditional whole licorice root for short-term use, Nature’s Way Licorice Root provides a trusted, Non-GMO Project Verified option from a company with over 50 years of herbal supplement experience—just remember to limit use to 4-6 weeks and monitor blood pressure.
Whichever product you choose, licorice root remains one of the most time-tested herbs for digestive wellness. Start with a lower dose to assess tolerance, follow product-specific timing recommendations (especially for chewables), and consult your healthcare provider if you have existing health conditions or take medications.
