Best Benfotiamine Supplements (2026) – Top 10 Reviewed
Benfotiamine is a fat-soluble form of vitamin B1 (thiamine) that offers superior absorption compared to standard thiamine supplements. It’s particularly popular for supporting nerve health, healthy blood sugar metabolism, and protecting against oxidative stress.
The best benfotiamine supplements use high-quality ingredients like BenfoPure, provide clinically relevant dosages (150-600mg), and come from reputable manufacturers with third-party testing. Here are our top 10 picks for 2026.
| Product | Dosage | Servings | Form | Best For |
|---|---|---|---|---|
| Doctor’s Best Benfotiamine 300 with BenfoPure | 300mg | 60 | Capsules | Best Overall |
| Life Extension Mega Benfotiamine | 250mg + 10mg thiamine | 120 | Capsules | Best Dual-Form Formula |
| NatureBell Benfotiamine 300mg | 300mg + 100mg thiamine | 120 | Capsules | Best Value |
| Double Wood Benfotiamine | 300mg | 60 | Capsules | Best Budget Option |
| Nutricost Benfotiamine 600mg | 600mg | 90 | Capsules | Best High-Potency |
| Pure Encapsulations BenfoMax | 200mg | 90 | Capsules | Best Premium Option |
| BESTVITE Benfotiamine 300mg | 300mg | 60 | Capsules | Best Clean Formula |
| Life Extension Benfotiamine with Thiamine | 100mg + 25mg thiamine | 120 | Capsules | Best for Beginners |
| Source Naturals Benfotiamine | 150mg | 120 | Tablets | Best Tablets |
| Alpha Lipoic Acid 600mg with Benfotiamine | 600mg ALA + Benfotiamine + B1 + B12 | 60 | Capsules | Best Nerve Support Combo |
1. Doctor’s Best Benfotiamine 300 with BenfoPure – Best Overall
Why it stands out: Doctor’s Best uses BenfoPure, a patented form of benfotiamine known for its purity and consistent quality. This supplement delivers a clinically meaningful 300mg dose in each vegetarian capsule, matching the doses used in research studies.
This formula activates transketolase, a cellular enzyme essential for healthy glucose metabolism. The fat-soluble nature means better absorption than standard water-soluble thiamine, with research suggesting it raises blood thiamine levels more effectively. Doctor’s Best has been a trusted name in supplements for decades, and their commitment to science-based formulas shows here. The company provides clear labeling, third-party testing certificates, and educational content about their ingredients.
Each bottle provides a 60-day supply at the recommended one capsule per day dosage. The vegetarian capsules are easy to swallow and don’t have the unpleasant odor sometimes associated with B vitamins. Users consistently report good tolerance, and the price point makes this accessible for long-term supplementation. For those serious about supporting their glucose metabolism and nerve health, this is our top recommendation.
Pros:
- Uses patented BenfoPure ingredient
- Clinically effective 300mg dose
- Vegan, non-GMO, gluten-free, and soy-free
- Affordable price point for quality
- Easy one-capsule-per-day dosing
Cons:
- Single-ingredient formula (no added thiamine)
- 60-day supply may require more frequent reordering
Best for: Anyone seeking a straightforward, high-quality benfotiamine supplement from a trusted brand.
2. Life Extension Mega Benfotiamine – Best Dual-Form Formula
Why it stands out: Life Extension combines 250mg of fat-soluble benfotiamine with 10mg of water-soluble thiamine HCl, covering both absorption pathways for comprehensive B1 support.
This dual-form approach makes sense from a biochemistry standpoint. Benfotiamine penetrates cell membranes easily due to its fat-soluble nature, while standard thiamine works through different cellular mechanisms. Together, they help protect against advanced glycation end products (AGEs) and support healthy endothelial function. Life Extension has been in the supplement business for over 40 years and funds significant anti-aging research. The 120-capsule bottle can last up to four months depending on your dosage needs.
Pros:
- Combines fat-soluble and water-soluble B1 forms
- Backed by extensive research
- Large bottle size offers excellent value
- Flexible dosing (1-4 capsules daily)
Cons:
- Slightly lower benfotiamine dose than some competitors
Best for: Those who want comprehensive vitamin B1 coverage from a research-focused brand.
3. NatureBell Benfotiamine 300mg – Best Value
Why it stands out: NatureBell delivers 300mg of benfotiamine plus 100mg of thiamine per serving in a massive 240-capsule bottle, making it one of the best values on the market.
This formula provides both the fat-soluble derivative and traditional water-soluble thiamine, giving you comprehensive B1 support. The 240-capsule count means a 120-day supply at the standard two-capsule serving size—that’s four months of supplementation from a single bottle. NatureBell maintains strict quality standards with third-party lab testing for safety and potency. The formula is free from soy, wheat, dairy, gluten, eggs, fish, and tree nuts, making it suitable for those with common allergen sensitivities.
Pros:
- Exceptional value with 240 capsules
- Includes both benfotiamine and thiamine
- Third-party tested
- Free from major allergens
Cons:
- Requires two capsules per serving
Best for: Budget-conscious consumers who want long-term supplementation without frequent reordering.
4. Double Wood Benfotiamine – Best Budget Option
Why it stands out: Double Wood offers a quality benfotiamine supplement at one of the lowest price points in the category, without sacrificing on testing or purity standards.
Each bottle contains 120 capsules at 150mg each, designed to be taken as two capsules (300mg) per day. This split-dose approach allows flexibility—you can take one capsule with lunch and one with dinner for sustained B1 levels throughout the day. Double Wood manufactures in the USA and subjects all products to rigorous third-party testing for heavy metals and microbes. The formula is vegetarian-friendly, non-GMO, and gluten-free. For those new to benfotiamine or on a tight budget, this is an excellent entry point.
Pros:
- Very affordable price point
- Third-party tested in the USA
- Flexible dosing with 150mg capsules
- 60-day supply per bottle
Cons:
- Need two capsules for full 300mg dose
- Less established brand than some competitors
Best for: First-time benfotiamine users or those seeking quality supplementation on a budget.
5. Nutricost Benfotiamine 600mg – Best High-Potency
Why it stands out: Nutricost delivers 600mg of benfotiamine per serving—double the dose of most competitors—for those who need maximum support or have been directed by healthcare providers to take higher amounts.
This high-potency formula is manufactured in an NSF Certified, GMP Compliant, FDA Registered facility, ensuring pharmaceutical-grade quality control. The 180-capsule bottle provides 90 servings (two capsules per serving), making it a three-month supply at the full 600mg dose. Nutricost is known for offering straightforward, single-ingredient supplements without unnecessary additives, and their benfotiamine follows this philosophy with a clean, simple formula.
The higher dose may be particularly relevant for those who have been supplementing for a while and want to increase their intake, or for individuals with specific health goals that benefit from more aggressive support. Research has used doses up to 600mg daily safely for extended periods, making this an excellent choice for those who’ve already established their tolerance and know they respond well to benfotiamine. The formula is vegan, gluten-free, and non-GMO, with transparent labeling that shows exactly what you’re getting.
Pros:
- Highest potency option at 600mg
- NSF Certified manufacturing facility
- 90-serving bottle size for three-month supply
- Clean formula with minimal fillers
- Excellent value for the dose provided
Cons:
- Higher dose may not be necessary for everyone
- Two capsules required per serving
- May be overkill for beginners
Best for: Experienced users who need higher doses or those directed by healthcare providers to take 600mg daily.
6. Pure Encapsulations BenfoMax – Best Premium Option
Why it stands out: Pure Encapsulations uses Japanese-sourced BenfoPure and hypoallergenic ingredients, making this ideal for sensitive individuals or those who demand clinical-grade purity.
Pure Encapsulations is a practitioner-favorite brand known for its commitment to pure, research-backed formulas. BenfoMax contains 200mg of benfotiamine per capsule, sourced from premium Japanese benfotiamine. The formula is completely free from common allergens, artificial additives, and unnecessary fillers—just the active ingredient in a vegetarian cellulose capsule. This makes it particularly suitable for those with autoimmune conditions, chemical sensitivities, or complex supplement regimens where interactions are a concern.
Pros:
- Hypoallergenic formula
- Premium Japanese benfotiamine source
- Trusted by healthcare practitioners
- No artificial ingredients or fillers
Cons:
- Higher price than most competitors
- Lower dose (200mg) per capsule
Best for: Those with sensitivities, autoimmune conditions, or who prefer practitioner-grade supplements.
7. BESTVITE Benfotiamine 300mg – Best Clean Formula
Why it stands out: BESTVITE’s formula contains no stearates, no silicon dioxide, and no unnecessary additives—just pure benfotiamine in a vegetarian capsule.
Many supplements include magnesium stearate as a flow agent and silicon dioxide as an anti-caking agent. While these are generally considered safe, some health-conscious consumers prefer to avoid them. BESTVITE eliminates these additives entirely while maintaining a potent 300mg dose. The company manufactures in an NSF GMP Certified facility in the USA and conducts third-party testing before release. This clean-label approach appeals to purists who want nothing but the active ingredient.
Pros:
- No stearates or silicon dioxide
- NSF GMP Certified manufacturing
- Full 300mg dose per capsule
- Vegan and non-GMO
Cons:
- Smaller bottle size (60 capsules)
- Single-ingredient formula
Best for: Purists who want to minimize inactive ingredients in their supplements.
8. Life Extension Benfotiamine with Thiamine – Best for Beginners
Why it stands out: With 100mg of benfotiamine and 25mg of thiamine per capsule, this lower-dose formula is perfect for those new to benfotiamine supplementation.
Starting with a lower dose allows you to assess your individual tolerance and response before moving to higher amounts. The formula recommends taking one capsule four times daily, but beginners can start with just one or two capsules and gradually increase. This approach aligns with the general supplement principle of starting low and going slow. The 120-capsule bottle provides flexibility in dosing and can last anywhere from one to four months depending on your protocol. Life Extension’s quality standards and research backing make this a safe choice for newcomers.
Pros:
- Lower dose ideal for assessing tolerance
- Combines both B1 forms
- Flexible dosing options
- Large bottle size
Cons:
- Multiple capsules needed for higher doses
- Lower potency per capsule
Best for: Those new to benfotiamine who want to start conservatively.
9. Source Naturals Benfotiamine – Best Tablets
Why it stands out: Source Naturals offers benfotiamine in tablet form rather than capsules, which some users prefer for ease of swallowing or dosage splitting.
Founded in 1982, Source Naturals is known for its Bio-Aligned Formulas that take an integrative approach to health. This benfotiamine product delivers 150mg per tablet, allowing for precise dose customization. Tablets can be easier to cut in half for those who want even smaller doses, something that’s difficult with capsules. The formula supports healthy carbohydrate and glycemic levels by promoting transketolase enzyme activity, which is essential for normal metabolic pathways. Each bottle contains 120 tablets for a 30-120 day supply depending on dosage.
Pros:
- Tablet form for easy splitting
- Trusted brand with 40+ years history
- 120-tablet bottle
- Moderate 150mg dose per tablet
Cons:
- Contains some inactive ingredients
- Tablets may be harder to digest than capsules for some
Best for: Those who prefer tablets over capsules or want to customize their dose by splitting tablets.
10. Alpha Lipoic Acid 600mg with Benfotiamine – Best Nerve Support Combo
Why it stands out: This comprehensive formula combines alpha lipoic acid with benfotiamine, B1, and B12—all nutrients extensively studied for their role in nerve health—in one convenient supplement designed for comprehensive neurological support.
Alpha lipoic acid (ALA) is a powerful antioxidant that works synergistically with benfotiamine to support nerve function and glucose metabolism. Both nutrients have been individually studied for their potential benefits in supporting nerve comfort and healthy nerve function. The addition of vitamins B1 and B12 rounds out this nerve-focused formula, as both B vitamins play crucial roles in maintaining the myelin sheath that protects nerve fibers.
Research has examined both ALA and benfotiamine individually for supporting nerve comfort, and combining them in one supplement simplifies your daily regimen considerably. Instead of taking multiple separate supplements, you get a comprehensive nerve support stack in just one formula. The formula is lab-tested, non-GMO, and vegan, with 120 capsules providing a two-month supply at the recommended dosage. For those specifically targeting nerve health rather than benfotiamine alone, this combination approach offers excellent convenience and potential synergistic benefits.
Pros:
- Synergistic nerve support ingredients
- High-potency 600mg ALA
- Includes B12 for additional nerve support
- Two-month supply per bottle
- Simplifies supplement regimen
Cons:
- Can’t adjust benfotiamine dose independently
- More expensive than single-ingredient options
- May overlap with other B vitamins you’re taking
Best for: Those specifically seeking nerve health support who want multiple beneficial ingredients in one formula.
What is Benfotiamine and Who Should Take It?
Benfotiamine is a synthetic, fat-soluble derivative of thiamine (vitamin B1) that was first developed in Japan in the 1960s. Unlike water-soluble thiamine, benfotiamine can penetrate cell membranes more easily, resulting in higher and more sustained blood levels of active thiamine. Research suggests that benfotiamine may raise blood thiamine levels up to five times more effectively than standard thiamine supplements. Once absorbed, your body converts it to thiamine pyrophosphate (TPP), the biologically active coenzyme form that’s essential for glucose metabolism.
The primary mechanism by which benfotiamine works involves activating transketolase, a crucial enzyme in the pentose phosphate pathway. This pathway helps your body process glucose and manage blood sugar levels effectively. Benfotiamine also helps inhibit the formation of advanced glycation end products (AGEs)—harmful compounds that form when proteins or fats combine with sugars. AGEs accumulate with age and are associated with various age-related concerns.
People who may benefit from benfotiamine supplementation include those looking to support healthy blood sugar metabolism already within normal range, individuals concerned about nerve comfort and function, and anyone wanting enhanced B1 absorption compared to standard thiamine supplements. It’s particularly popular among those following low-carb or ketogenic diets, individuals interested in anti-aging strategies, and people who want to support their nervous system health. Additionally, those who consume alcohol regularly may benefit, as alcohol can deplete thiamine levels.
How to Choose the Right Benfotiamine Supplement
Key Ingredients to Look For
The best benfotiamine supplements provide 150-600mg per serving, with 300mg being the most common clinically studied dose. Look for products that use branded ingredients like BenfoPure, which indicates third-party verification of purity and consistent quality batch after batch. Some formulas combine benfotiamine with standard thiamine (thiamine HCl) to provide both fat-soluble and water-soluble B1 forms—this can offer more comprehensive support since each form works through slightly different cellular mechanisms.
Consider whether you want a standalone benfotiamine product or a combination formula. Standalone products give you precise control over your dose and allow easy adjustment. Combination formulas that include alpha lipoic acid, additional B vitamins, or other synergistic nutrients can simplify your supplement routine if you’re targeting specific health goals like nerve support. Look for products manufactured in GMP-certified facilities, ideally with NSF certification for additional quality assurance.
Forms Compared
Capsules are the most common form and typically offer the best absorption since the benfotiamine is released quickly in the digestive tract. Vegetarian capsules made from hypromellose (cellulose) are preferred by those avoiding animal-derived gelatin. Tablets may contain more binding agents but can be easier to split for dose customization—a useful feature if you want to start with lower amounts and gradually increase. Softgels with oil-based carriers like coconut oil or MCT may enhance absorption of this fat-soluble nutrient, though they’re less common in the benfotiamine market.
Powder forms exist but are rare for benfotiamine specifically. If you find them, they offer maximum dosing flexibility but require accurate measuring. Gummy forms, while popular for other supplements, typically contain lower benfotiamine doses and often include added sugars, which somewhat defeats the purpose for those taking benfotiamine to support glucose metabolism.
What to Avoid
Steer clear of supplements with proprietary blends that don’t disclose the exact benfotiamine amount—you need to know your dose. Avoid products with excessive fillers, artificial colors, flavors, or unnecessary additives. While ingredients like magnesium stearate and silicon dioxide are generally considered safe, some consumers prefer to avoid them, and cleaner options exist. Be cautious of extremely cheap options from unknown manufacturers that may not undergo proper third-party testing for purity, potency, and contaminants.
Check the serving size carefully. A product advertising “600mg benfotiamine” might require taking multiple capsules to achieve that dose. Read labels to understand how many capsules constitute one serving. Always verify that the manufacturer follows Good Manufacturing Practices (GMP) and ideally has NSF, USP, or similar third-party certification. Be wary of products making disease claims, as legitimate supplement companies understand FDA regulations and avoid such claims.
Side Effects and Precautions
Benfotiamine is generally well-tolerated at doses up to 600mg daily for extended periods, with research lasting up to 24 weeks showing a favorable safety profile. The most commonly reported side effects are mild and include occasional stomach upset, nausea, and skin rashes in sensitive individuals. These effects are relatively rare and typically resolve when the supplement is taken with food or the dose is reduced.
Taking benfotiamine with meals can help minimize digestive discomfort significantly. Since it’s fat-soluble, consuming it with some dietary fat—even just a few nuts or a meal containing olive oil—may enhance absorption and reduce any gastric upset. If you experience persistent side effects, try splitting your daily dose into smaller amounts taken throughout the day rather than one larger dose.
Those who are pregnant, nursing, or taking medications should consult a healthcare provider before starting benfotiamine. While no significant drug interactions have been firmly established, it’s wise to discuss supplementation with your doctor if you’re on diabetes medications, as benfotiamine may support glucose metabolism and could theoretically affect blood sugar levels. People with sulfur sensitivities should note that benfotiamine contains sulfur in its chemical structure, though reactions are uncommon.
Individuals with kidney disease should exercise caution and consult their healthcare provider, as high doses of B vitamins in general require renal clearance. If you’re scheduled for surgery, inform your healthcare team about all supplements you take, including benfotiamine. While there’s no established concern, full disclosure helps your medical team make informed decisions.
FAQs
What is the recommended dosage for benfotiamine?
Most research uses doses between 150-600mg daily. A typical starting dose is 150-300mg per day, which can be increased based on individual needs and healthcare provider recommendations. Higher doses up to 600mg have been used safely in studies lasting up to 24 weeks. If you’re new to benfotiamine, starting at the lower end allows you to assess your tolerance before increasing.
When is the best time to take benfotiamine?
Take benfotiamine with meals for optimal absorption, as it’s fat-soluble and benefits from dietary fat. Breakfast or lunch are often ideal since B vitamins can provide an energy boost that might affect sleep if taken late in the day. If taking multiple doses, splitting them between meals (such as lunch and dinner) can help maintain more consistent blood levels throughout the day.
How long does it take to notice benefits from benfotiamine?
Individual responses vary significantly, but most people report noticing effects within 2-4 weeks of consistent daily use. Studies examining nerve comfort typically show measurable benefits after 6-12 weeks of supplementation. For blood sugar metabolism support, some users report noticing changes sooner. Consistency is key—taking benfotiamine regularly yields better results than sporadic use.
Can I take benfotiamine with other B vitamins?
Yes, benfotiamine works well alongside other B vitamins and is often included in B-complex formulas or taken alongside them. It can be particularly synergistic with vitamin B12 for nerve health support, and some research has examined combinations with B6 as well. There are no known negative interactions between benfotiamine and other B vitamins, and many people stack them together.
Is benfotiamine safe for long-term use?
Current research suggests benfotiamine is safe for long-term supplementation. Studies lasting up to 24 weeks at 600mg daily have not revealed significant safety concerns beyond mild, rare side effects. Many people take benfotiamine continuously for years. However, as with any supplement, periodic reassessment with your healthcare provider is advisable for ongoing use to ensure it remains appropriate for your situation.
What’s the difference between benfotiamine and regular thiamine?
Benfotiamine is fat-soluble while regular thiamine (thiamine HCl or thiamine mononitrate) is water-soluble. This fundamental difference makes benfotiamine more bioavailable—it’s absorbed better, penetrates cell membranes more easily, and maintains higher blood levels for longer periods. Some research suggests benfotiamine raises thiamine levels up to five times more effectively than standard thiamine supplements, making it a more efficient way to boost B1 status.
Final Verdict
For most people, Doctor’s Best Benfotiamine 300 with BenfoPure offers the best combination of quality, effective dosing, and value. The patented BenfoPure ingredient ensures consistent purity, and the 300mg dose aligns with what’s been used in clinical research. It’s our top recommendation for anyone starting benfotiamine supplementation or looking for a reliable daily option.
If you’re on a tight budget, Double Wood Benfotiamine delivers solid quality at one of the lowest price points in the category without sacrificing third-party testing or manufacturing standards. For those seeking comprehensive nerve support, the Alpha Lipoic Acid with Benfotiamine combo formula provides synergistic benefits in one convenient supplement—ideal if nerve health is your primary goal.
Premium supplement shoppers should consider Pure Encapsulations BenfoMax for its hypoallergenic formula and practitioner-grade quality. And if you need the highest potency available, Nutricost’s 600mg formula offers maximum dosing in an NSF-certified product. Regardless of which option you choose, benfotiamine remains one of the most effective ways to support your body’s B1 levels, with superior absorption compared to standard thiamine supplements.
