Best DHEA Supplements (2026) – Top 10 Reviewed
DHEA (dehydroepiandrosterone) is the body’s most abundant circulating hormone, serving as a building block for testosterone and estrogen. Since levels peak in your mid-20s and decline steadily with age, supplementation has become popular for supporting hormone balance, energy, mood, and healthy aging.
The best DHEA supplements use micronized forms for better absorption and come from brands with third-party testing. Here are our top 10 picks for 2026.
| Product | Dosage | Servings | Form | Best For |
|---|---|---|---|---|
| Pure Encapsulations DHEA | 25mg | 180 | Capsules | Best Overall |
| Life Extension DHEA | 25mg | 100 | Capsules | Best for Longevity |
| Nutricost DHEA 50mg | 50mg | 240 | Capsules | Best Value |
| Zhou Nutrition Clarity & Vitality | 50mg | 60 | Capsules | Best for Healthy Aging |
| Havasu Nutrition DHEA | 50mg | 60 | Capsules | Best for Energy |
| Horbäach DHEA 100mg | 100mg | 200 | Capsules | Best High-Potency |
| Natrol DHEA | 25mg | 300 | Tablets | Best Budget Option |
| Double Wood DHEA | 100mg | 180 | Capsules | Best for Men |
| Nutricost DHEA 100mg | 100mg | 240 | Capsules | Best High-Dose Value |
| Life Extension DHEA Dissolve | 25mg | 100 | Dissolve Tablets | Best Sublingual |
1. Pure Encapsulations DHEA – Best Overall
Why it stands out: Pure Encapsulations uses pharmaceutical-grade, micronized DHEA that absorbs significantly better than standard formulations. Their hypoallergenic approach means no fillers, additives, or common allergens—ideal for those with sensitivities.
Each vegetarian capsule delivers 25mg of micronized DHEA—the clinically recommended starting dose for most adults over 40. The micronization process reduces particle size for enhanced bioavailability, meaning more of the supplement actually reaches your bloodstream rather than passing through unabsorbed. Pure Encapsulations is trusted by healthcare practitioners worldwide and undergoes rigorous third-party testing for purity and potency. At 180 capsules per bottle, you get a full 6-month supply, making the higher price point more reasonable when calculated per serving. The formula uses only hypoallergenic plant fiber and a vegetarian capsule shell—nothing else. This minimal approach is why doctors often recommend Pure Encapsulations to patients with multiple sensitivities.
Pros:
- Micronized for superior absorption
- Hypoallergenic, clean formula with no additives
- Trusted by healthcare practitioners
- 6-month supply per bottle
- Vegetarian-friendly capsules
Cons:
- Higher price point than competitors
- Only available in 25mg dose
Best for: Anyone wanting a premium, practitioner-grade DHEA supplement with optimal absorption and minimal additives.
2. Life Extension DHEA – Best for Longevity
Why it stands out: Life Extension has over 40 years of research-backed formulation experience, and their DHEA supplement is specifically designed with healthy aging in mind. They fund and publish clinical research, setting them apart from most supplement brands.
Life Extension delivers 25mg of DHEA per capsule in a formula designed to support hormone balance, cognitive health, bone density, and lean muscle mass. Clinical studies cited by the company show DHEA supplementation promoted strength and muscle mass from resistance exercise in elderly individuals over 10 months. They also reference research showing DHEA may support bone mineral density, particularly in postmenopausal women. The company recommends blood testing to personalize your dosage, which reflects their science-first approach to supplementation. Life Extension provides a Certificate of Analysis for every product they manufacture, and their formulas are non-GMO and gluten-free. The 100-capsule bottle provides over 3 months of daily use.
Pros:
- Research-backed formulation from a science-focused company
- Supports multiple aspects of healthy aging
- Non-GMO and gluten-free
- Certificate of Analysis available for transparency
- Appropriate starting dose at 25mg
Cons:
- Smaller bottle (100 capsules) than some competitors
- Premium pricing reflects research investment
Best for: Those focused on longevity and healthy aging who want a scientifically-formulated supplement from a research-driven company.
3. Nutricost DHEA 50mg – Best Value
Why it stands out: Nutricost delivers exceptional value with 240 capsules of 50mg DHEA at a price point that’s hard to beat, all while maintaining quality standards that rival premium brands.
Each bottle provides an 8-month supply at the standard 50mg dose, making this one of the most economical DHEA options on the market. Nutricost products are manufactured in a GMP-compliant, FDA-registered facility and undergo third-party testing by ISO-accredited laboratories—the same standards you’d expect from brands charging twice as much. The formula is impressively clean—gluten-free, soy-free, and non-GMO—with no artificial additives. The only other ingredients are rice flour and a hypromellose capsule. The 50mg dose works well for those who’ve already started with 25mg and want to step up, or for those whose healthcare providers have recommended this dosage. Nutricost has built a strong reputation among budget-conscious health enthusiasts who don’t want to sacrifice quality for affordability.
Pros:
- Outstanding value (8-month supply at one bottle)
- Third-party tested by ISO-accredited laboratories
- Clean, simple formula with minimal fillers
- GMP-compliant, FDA-registered manufacturing facility
- Non-GMO, gluten-free, and soy-free
Cons:
- Not micronized for enhanced absorption
- 50mg may be too high for complete beginners
Best for: Budget-conscious shoppers who want a quality DHEA supplement without premium pricing, especially those ready for the 50mg dose.
4. Zhou Nutrition Clarity & Vitality – Best for Healthy Aging
Why it stands out: Zhou Nutrition’s DHEA formula (formerly called “DHEA 50mg”) is specifically marketed for hormonal balance and healthy aging, with a focus on mental clarity and vitality. The name change to “Clarity & Vitality” reflects the benefits users report most frequently.
Zhou delivers 50mg of DHEA per vegetarian capsule in a non-GMO, gluten-free formula designed for daily use. The company follows strict GMP standards during production and conducts additional third-party lab testing before releasing any batch—a dual-verification approach that builds confidence in quality. Users frequently report improvements in energy, mental clarity, and overall vitality within the first few weeks of supplementation. The formula is 100% vegetarian-friendly with a cellulose-based capsule, making it accessible for those with dietary restrictions or those who avoid animal-derived ingredients. Zhou has built a strong reputation in the supplement industry for transparent practices and consistent quality across their product line.
Pros:
- Dual-tested for quality assurance (GMP + third-party)
- 100% vegetarian formula
- Supports mental clarity and energy
- Reputable brand with consistently strong reviews
- Non-GMO and gluten-free
Cons:
- Only 60 capsules per bottle (2-month supply)
- Higher cost per serving than bulk options
Best for: Those seeking a quality DHEA supplement with a focus on cognitive clarity and healthy aging from a trusted brand.
5. Havasu Nutrition DHEA – Best for Energy
Why it stands out: Havasu Nutrition’s DHEA is formulated specifically to support youthful energy levels and mood, with a clean formula free from common allergens that’s ideal for sensitive individuals.
Each capsule provides 50mg of DHEA to help replenish levels that naturally decline after age 25. Havasu focuses heavily on purity—their formula is vegan, non-GMO, and completely free from dairy, eggs, peanuts, and other common allergens. The capsules are manufactured in a cGMP-certified facility in the USA, with quality checks at every stage of production. Users consistently report noticeable improvements in energy and mood within the first few weeks of supplementation, with many noting they feel more like their younger selves. The dose is flexible; you can take one capsule daily or increase to two (100mg total) if recommended by your healthcare provider and tolerated well. As a small business brand, Havasu offers responsive customer service that larger companies often lack.
Pros:
- Clean, comprehensive allergen-free formula
- Vegan-friendly capsules
- Small business brand with quality focus and good customer service
- Flexible dosing options (50mg or 100mg daily)
- Made in USA in cGMP facility
Cons:
- Only 2-month supply per bottle
- Slightly higher price point than some budget options
Best for: Those seeking an energy boost from a clean, allergen-free DHEA supplement, especially those with food sensitivities.
6. Horbäach DHEA 100mg – Best High-Potency
Why it stands out: Horbäach delivers maximum strength 100mg DHEA in quick-release capsules for those who need higher doses under healthcare guidance or want the flexibility to split capsules for custom dosing.
With 200 capsules of 100mg DHEA, this bottle provides over 6 months of daily supplementation at the highest commonly used dose—exceptional value for those who’ve been prescribed this potency. Horbäach has over 40 years in the natural products industry and maintains strict quality standards across their extensive supplement line. Their formula is non-GMO, gluten-free, and free from artificial colors, sweeteners, and preservatives. The quick-release capsules are designed for fast absorption, getting DHEA into your system efficiently. User reviews frequently mention improvements in energy, muscle definition when combined with exercise, and overall vitality. This potency is best suited for those who’ve been advised by healthcare providers to take higher doses after blood testing, or for those who want to split capsules to achieve a custom 50mg dose.
Pros:
- Maximum 100mg potency for those who need it
- 200-capsule supply (6+ months at full dose)
- Quick-release capsules for efficient absorption
- 40+ years of brand experience in natural products
- Free from artificial additives
Cons:
- 100mg may be too strong for beginners—start lower
- Not micronized for enhanced absorption
- Gelatin capsules (not vegetarian)
Best for: Those who need higher DHEA doses under healthcare guidance, or anyone wanting flexibility to split capsules for custom dosing.
7. Natrol DHEA – Best Budget Option
Why it stands out: Natrol delivers 300 tablets at 25mg each, making it one of the most affordable ways to maintain consistent DHEA supplementation over nearly a full year—unmatched value for cost-conscious consumers.
Natrol’s DHEA formula includes added calcium (from calcium carbonate) and comes in easy-to-swallow tablets rather than capsules. The 25mg dose is perfect for beginners or those who want to take a conservative approach to DHEA supplementation—it’s the dose most commonly recommended by healthcare providers as a starting point. Natrol products are non-GMO, vegetarian, and gluten-free with no artificial flavors, sweeteners, or synthetic dyes. The company has built a solid reputation for quality over decades in the supplement industry and is widely available in retail stores as well as online. At 300 tablets, you get nearly a year’s supply at an unbeatable price per serving—often under 5 cents per day. Users frequently report improvements in mood, energy, and overall well-being, with many noting fewer menopause symptoms.
Pros:
- 300-tablet supply (nearly 1 year of daily use)
- Perfect 25mg beginner dose
- Added calcium for bone support
- Vegetarian and non-GMO
- Widely trusted brand available everywhere
Cons:
- Tablet form rather than capsules
- Contains minimal fillers and binding agents
- Not micronized
Best for: Budget-conscious beginners who want a year’s worth of DHEA at the recommended starting dose from a trusted brand.
8. Double Wood DHEA – Best for Men
Why it stands out: Double Wood’s 100mg formula is specifically marketed for supporting hormone balance and healthy aging in men, with a focus on quality, transparency, and the higher potency many men prefer.
Double Wood provides 180 capsules of 100mg DHEA—a 6-month supply at the higher potency that many men find effective. The company emphasizes quality with third-party testing for both purity and potency, and all products are manufactured and tested in the USA. The 100mg dose can support testosterone production in men experiencing age-related hormone decline, though this should be monitored with blood tests. Double Wood’s transparent approach includes clear labeling, accessible customer service, and detailed product information on their website. The formula is non-GMO and gluten-free, with minimal additional ingredients. Users report improvements in energy, workout recovery, and overall vitality, though individual results vary.
Pros:
- 6-month supply at 100mg potency
- Third-party tested for purity and potency in the USA
- Specifically formulated with men’s needs in mind
- Non-GMO and gluten-free
- Transparent company with good customer service
Cons:
- Higher dose not suitable for everyone—requires healthcare guidance
- Gelatin capsules (not vegetarian)
- May cause side effects at this potency
Best for: Men over 40 seeking a high-potency DHEA supplement to support hormone balance and vitality.
9. Nutricost DHEA 100mg – Best High-Dose Value
Why it stands out: Nutricost’s 100mg option delivers the same rigorous quality as their 50mg version but at maximum strength, with an industry-leading 240 capsules per bottle that’s hard to beat on value.
At 240 capsules of 100mg each, this is one of the best values for high-dose DHEA on the market—an 8-month supply at the highest commonly used potency for significantly less than competitors. Nutricost maintains their commitment to quality with third-party ISO-accredited testing and GMP-compliant manufacturing, ensuring every batch meets their standards. The formula stays clean and simple: just DHEA, rice flour, and a hypromellose (vegetarian) capsule. No artificial colors, flavors, or unnecessary additives. This makes it suitable for those who need higher doses under healthcare guidance and want maximum value for their supplement budget. The large bottle also means fewer reorders and consistent supply.
Pros:
- 8-month supply at maximum 100mg potency
- Exceptional price per serving—best value for high-dose
- Third-party tested by ISO-accredited labs
- Minimal, clean ingredients
- Vegetarian capsules
Cons:
- 100mg is not appropriate for beginners
- Should only be used under healthcare provider guidance
- Not micronized
Best for: Those who’ve been advised to take 100mg DHEA and want the best long-term value from a quality manufacturer.
10. Life Extension DHEA Dissolve – Best Sublingual
Why it stands out: Life Extension’s dissolve-in-mouth tablets offer an alternative delivery method that may improve absorption for those who have difficulty swallowing capsules or want faster uptake through sublingual delivery.
These 25mg tablets dissolve under the tongue, allowing DHEA to be absorbed directly through the oral mucosa rather than passing through the digestive system and initial liver metabolism. This sublingual delivery may result in faster absorption and potentially higher bioavailability for some users, though individual results vary. Life Extension’s formula maintains the same research-backed approach as their capsule version, supporting hormone balance, cognitive health, bone density, and muscle mass. The 100-tablet bottle provides over 3 months of supplementation at the standard 25mg dose. The dissolve-in-mouth format is also convenient for those who travel frequently or prefer not to take pills with water.
Pros:
- Sublingual delivery may enhance absorption
- No swallowing capsules required—great for those with difficulty swallowing
- Research-backed Life Extension formula
- Convenient dissolve-in-mouth format
- Standard 25mg dose suitable for most users
Cons:
- Smaller serving count (100 tablets) than bulk options
- Some users may not prefer the sublingual experience
- Takes 1-2 minutes to fully dissolve
Best for: Those who prefer sublingual supplements, have difficulty swallowing pills, or want potentially faster DHEA absorption.
What is DHEA and Who Should Take It?
DHEA (dehydroepiandrosterone) is a hormone produced primarily by your adrenal glands, with smaller amounts made by the ovaries, testes, and brain. Often called the “mother hormone,” it serves as a precursor that your body converts into testosterone, estrogen, and other steroid hormones as needed. This conversion happens in your cells and is regulated by your body’s requirements, which is why DHEA supplementation doesn’t simply flood your system with sex hormones.
DHEA levels peak in your mid-20s—typically around age 25—then decline approximately 2-3% per year thereafter. By age 40, most people have lost about 50% of their peak DHEA, and by age 75, levels may have dropped by as much as 80%. This natural decline has been associated with age-related changes in energy, body composition, cognitive function, and overall vitality, though the relationship between low DHEA and these symptoms isn’t always direct.
People who may benefit from DHEA supplementation include adults over 40 experiencing age-related energy decline, those with documented low DHEA-S levels on blood tests, individuals seeking to support healthy aging and hormone balance, and women going through perimenopause or menopause who want to maintain hormone reserves. Some research suggests DHEA may help with symptoms like vaginal dryness in postmenopausal women when used as a vaginal insert (available by prescription). However, because DHEA is a hormone, it’s important to consult with a healthcare provider before starting supplementation, especially if you have hormone-sensitive conditions like breast cancer, prostate cancer, or endometriosis.
How to Choose the Right DHEA Supplement
Key Factors to Consider
Dosage: Most research supports starting with 25-50mg daily for adults over 40. Clinical studies showing benefits typically use 50mg, though starting at 25mg allows you to assess tolerance and monitor for side effects before increasing. Higher doses (100mg) should only be used under healthcare guidance after blood testing confirms they’re appropriate for your situation. Some practitioners recommend splitting higher doses throughout the day rather than taking them all at once.
Form: Micronized DHEA offers superior absorption because smaller particle sizes dissolve and absorb more efficiently in your digestive tract. Look for products that specifically state “micronized” on the label—this isn’t just marketing, it’s a measurable difference in particle size. Sublingual (dissolve-in-mouth) options may also enhance bioavailability by allowing DHEA to absorb directly through oral tissue, bypassing initial liver metabolism.
Third-Party Testing: Since DHEA is a hormone, quality matters significantly. Contaminated or underdosed products can lead to unpredictable results. Look for products tested by independent laboratories such as USP, NSF International, or ConsumerLab, or those with Certificates of Analysis available upon request. GMP (Good Manufacturing Practice) compliant manufacturing is also essential to ensure consistent quality between batches.
Brand Reputation: DHEA supplementation requires trust in your manufacturer. Established brands with long track records, transparent sourcing, and responsive customer service are preferable to unknown companies selling primarily on price.
Forms Compared
Capsules are the most common and convenient form, with options ranging from standard gelatin to vegetarian (cellulose-based) shells. They’re easy to dose and generally well-tolerated. Tablets are typically more affordable but may contain more binding agents and fillers to hold them together. Sublingual tablets dissolve under the tongue for potentially faster absorption and may be better for those with digestive issues. Topical creams and gels exist but are less common for general supplementation and harder to dose consistently.
What to Avoid
Avoid products without clear dosing information on the label, those making exaggerated claims about dramatic anti-aging effects or guaranteed hormone increases, and supplements with excessive fillers, artificial colors, or unnecessary additives. Be wary of DHEA products that don’t disclose their manufacturing standards or refuse to provide third-party testing documentation when requested. Also avoid “proprietary blends” that don’t tell you exactly how much DHEA you’re getting per serving.
Side Effects and Precautions
Common side effects of DHEA supplementation include acne, oily skin, and hair loss—particularly at higher doses or in those sensitive to androgens. These effects occur because DHEA can convert to testosterone and DHT, which stimulate sebaceous glands and hair follicles. Women may experience facial hair growth, voice deepening, or menstrual irregularities if doses are too high, as their bodies are more sensitive to androgenic effects. Some users report mood changes, irritability, or insomnia, especially when taking DHEA later in the day. Most people tolerate 25-50mg daily without significant issues, but individual responses vary considerably.
DHEA is not appropriate for everyone, and certain groups should avoid it entirely or use only under strict medical supervision. Those with hormone-sensitive conditions including breast cancer, prostate cancer, ovarian cancer, uterine fibroids, or endometriosis should not take DHEA, as it can potentially fuel hormone-dependent tissue growth. Pregnant and nursing women should not take DHEA due to potential effects on fetal and infant development. The supplement may interact with insulin and affect blood sugar levels, so those with diabetes should monitor closely and consult their healthcare provider. DHEA may also interact with medications that affect hormone levels, including hormone replacement therapy and some psychiatric medications. Athletes should note that DHEA is classified as a prohibited substance by most sports organizations including WADA (World Anti-Doping Agency), NCAA, and professional sports leagues—even over-the-counter DHEA supplements can cause positive drug tests.
FAQs
What is the best dosage of DHEA to start with?
Most experts recommend starting with 25mg daily for several weeks before considering an increase to 50mg. This allows you to assess tolerance and minimize potential side effects. Higher doses (100mg) should only be used under healthcare provider guidance after blood testing.
When should I take DHEA supplements?
Take DHEA in the morning with food to mimic your body’s natural production pattern, which peaks in early morning hours. Taking DHEA later in the day may interfere with sleep for some people.
How long does it take to see results from DHEA?
Most people notice improvements in energy and mood within 2-4 weeks of consistent supplementation. Changes in body composition, skin quality, or other benefits may take 2-3 months of regular use to become apparent.
Can DHEA supplements interact with medications?
Yes, DHEA may interact with hormone therapies, diabetes medications, and drugs metabolized by the liver. It can also affect insulin sensitivity. Always consult your healthcare provider before starting DHEA if you take prescription medications.
Is DHEA safe for long-term use?
Studies suggest DHEA is generally safe for up to two years at doses up to 50mg daily. Long-term safety data beyond this is limited. Regular blood testing to monitor DHEA-S levels is recommended for extended supplementation.
Should men and women take different DHEA doses?
Women typically require lower doses than men, often starting at 10-25mg, because they may be more sensitive to DHEA’s androgenic effects. Men often tolerate 25-50mg well. Individual response varies, so working with a healthcare provider to personalize dosing based on blood tests is ideal.
Final Verdict
For most people starting DHEA supplementation, Pure Encapsulations DHEA is our top recommendation thanks to its micronized formula for superior absorption, pharmaceutical-grade purity, and trusted reputation among healthcare practitioners. The 25mg dose is appropriate for beginners, and the 180-capsule bottle provides excellent long-term value when you calculate the cost per serving. If you want the best possible DHEA with minimal additives, this is the gold standard.
If budget is a primary concern, Nutricost DHEA 50mg delivers outstanding quality at an unbeatable price—240 capsules means you’re set for over 8 months, and the third-party testing gives confidence in what you’re taking. For those specifically focused on longevity and science-backed formulation, Life Extension DHEA brings over 40 years of research expertise to a clean, effective product with available Certificates of Analysis.
Men seeking higher-potency options should consider Double Wood DHEA at 100mg, which provides a 6-month supply with USA-based third-party testing. Those who prefer sublingual delivery or have difficulty swallowing pills will appreciate Life Extension’s dissolve-in-mouth tablets. And for the best value at high doses, Nutricost’s 100mg version offers 240 capsules at a price that’s hard to beat.
Whatever your needs, remember that DHEA is a hormone—not a simple vitamin or mineral. Consult with your healthcare provider before starting supplementation, especially if you have existing health conditions or take medications. Blood testing to check your DHEA-S levels before and during supplementation helps ensure you’re taking the right dose for your body.
