Best Apigenin Supplements for Sleep (2026) – Top 10 Reviewed
Apigenin has emerged as one of the most promising natural sleep aids of 2026, gaining serious attention from researchers, biohackers, and anyone struggling with sleep quality. This powerful flavonoid—the compound responsible for chamomile tea’s relaxing effects—works by binding to GABA receptors in the brain and reducing cortisol levels, promoting calm without the grogginess or dependency associated with melatonin or prescription sleep aids.
The best apigenin supplements deliver high purity (ideally 98%+), appropriate dosing (50-100mg for sleep support), and clean formulations without unnecessary fillers. Whether you’re looking to improve sleep onset, reduce nighttime wakeups, or simply unwind after stressful days, apigenin offers a science-backed solution. Here are our top 10 picks for 2026.
| Product | Key Ingredients | Servings | Form | Best For |
|---|---|---|---|---|
| Toniiq Ultra High Strength Apigenin | 100mg Apigenin (98%+) | 180 | Capsules | Best Overall |
| Momentous Apigenin | 50mg Apigenin | 60 | Capsules | Best Premium |
| Double Wood Apigenin | 50mg Apigenin | 120 | Capsules | Best Value |
| NatureBell Apigenin + L-Theanine | 50mg Apigenin, 100mg L-Theanine | 240 | Capsules | Best Combo Formula |
| Swanson Apigenin | 50mg Apigenin | 90 | Capsules | Best Budget |
| Nutricost Apigenin | 50mg Apigenin | 180 | Capsules | Best for Stacking |
| Native Nature Apigenin + L-Theanine | 100mg Apigenin, 400mg L-Theanine | 120 | Capsules | Best High-Potency Combo |
| aSquared Nutrition Apigenin + L-Theanine | 50mg Apigenin, 200mg L-Theanine | 120 | Capsules | Best for Beginners |
| Beam Dream Sleep Powder | Apigenin, L-Theanine, Reishi, Magnesium | 30 | Powder | Best Sleep Blend |
| Stacked Lab Apigenin + L-Theanine | Apigenin, L-Theanine | 60 | Capsules | Best Melatonin-Free Alternative |
1. Toniiq Ultra High Strength Apigenin – Best Overall
Why it stands out: Toniiq delivers an industry-leading 98%+ purity level with 100mg per capsule, making it one of the most potent and pure apigenin supplements available. Their rigorous third-party testing through independent laboratories ensures you’re getting exactly what’s on the label with no contaminants or adulterants.
While most apigenin supplements hover around 50mg per capsule, Toniiq’s 100mg dose hits the sweet spot for sleep support without requiring multiple capsules. The chamomile-derived apigenin undergoes additional purification steps that most competitors skip, resulting in that 98%+ standardization. The 180-capsule bottle provides a full 6-month supply at the recommended one-capsule dose, working out to just $0.17 per serving.
Manufacturing takes place in a GMP-certified, NSF-approved facility in the USA, and each batch undergoes independent testing for both purity and potential contaminants. The vegetarian capsules contain minimal fillers—just microcrystalline cellulose, vegetable capsule material, and silicon dioxide for flow. For anyone prioritizing potency and purity above all else, Toniiq sets the standard.
Pros:
- 98%+ purity level (highest available)
- 100mg potent dose per capsule
- 6-month supply per bottle (180 capsules)
- Third-party tested for purity and contaminants
- GMP-certified USA manufacturing
Cons:
- Higher dose may be too strong for sensitive users
- Vegetable capsule may not suit all preferences
Best for: Experienced supplement users, biohackers, or anyone wanting maximum potency without fillers or questionable ingredients.
2. Momentous Apigenin – Best Premium
Why it stands out: Momentous is the only apigenin supplement with NSF Certified for Sport certification, meaning it’s been rigorously tested for banned substances, label accuracy, and manufacturing quality. Their grapefruit-derived apigenin offers an alternative source for those who prefer non-chamomile options or have chamomile sensitivities.
At 50mg per capsule, Momentous takes a moderate dosing approach that works exceptionally well as part of their popular sleep stack—combined with Magnesium L-Threonate and L-Theanine for comprehensive sleep support. This combination, popularized by Stanford neuroscientist Andrew Huberman, targets multiple pathways involved in sleep onset and quality.
The clean formula contains minimal fillers (just rice flour, hypromellose capsule, L-leucine, and silica), and the brand’s partnerships with elite athletes and scientists lend significant credibility. While pricier at approximately $0.38 per serving, you’re paying for exceptional quality control, transparent sourcing, and the peace of mind that comes with NSF certification. The 60-capsule bottle provides a 2-month supply.
Pros:
- NSF Certified for Sport (rare for apigenin)
- Grapefruit-derived (chamomile alternative)
- Works synergistically with their sleep stack
- Clean, minimal ingredient formula
- Backed by scientific partnerships
Cons:
- Higher price per serving than competitors
- Lower 50mg dose requires stacking for some users
- Grapefruit source may interact with medications
Best for: Athletes subject to drug testing, biohackers following science-based protocols, or anyone prioritizing third-party certification and pristine purity.
3. Double Wood Apigenin – Best Value
Why it stands out: Double Wood delivers a reliable 50mg dose across 120 capsules at a highly competitive price point, backed by their growing reputation for clean, third-party tested supplements. Their vegan-friendly formula makes it accessible to plant-based consumers often excluded by gelatin capsules.
This straightforward formulation contains pure apigenin without unnecessary additives or proprietary blend obfuscation. The 120-capsule bottle provides a 2-4 month supply depending on whether you take 50mg or 100mg daily, and Double Wood’s commitment to transparency—they actually publish their third-party test results—builds significant consumer trust.
At around $0.20 per serving, Double Wood strikes an excellent balance between quality and affordability. The company has built a loyal following by offering research-backed supplements at accessible prices, and their apigenin is no exception. The soy-free, gluten-free, non-GMO formula suits most dietary restrictions.
Pros:
- Excellent price-to-quality ratio
- Vegan-friendly capsules
- Third-party tested with publicly available results
- 2-4 month supply per bottle
- Clean, simple ingredient list
Cons:
- 50mg dose may require doubling for sleep
- Less brand recognition than legacy companies
Best for: Budget-conscious consumers who refuse to sacrifice quality, or those wanting a reliable daily apigenin without premium pricing.
4. NatureBell Apigenin + L-Theanine – Best Combo Formula
Why it stands out: NatureBell combines 50mg apigenin with 100mg L-theanine per capsule (100mg apigenin and 200mg L-theanine per 2-capsule serving), creating a synergistic formula that amplifies relaxation benefits through complementary mechanisms. The massive 240-capsule bottle delivers exceptional long-term value.
L-theanine is the amino acid in green tea responsible for the calm, focused state tea drinkers often experience. Research shows it works synergistically with apigenin for sleep support—while apigenin activates GABA receptors, L-theanine promotes alpha brain wave activity associated with relaxed alertness and smooth transitions into sleep. This dual-pathway approach often produces better results than either ingredient alone.
The 4-month supply at the suggested 2-capsule dose makes NatureBell one of the most economical combo options available. The formula is non-GMO and free from major allergens (soy, dairy, gluten, wheat, eggs, fish, and tree nuts), though note that it uses gelatin capsules rather than vegetable cellulose. Third-party testing ensures potency and purity standards are met.
Pros:
- Synergistic apigenin + L-theanine formula
- 4-month supply (240 capsules)
- Non-GMO and major allergen-free
- Outstanding value for a combo supplement
- Consistent potency across batches
Cons:
- Contains gelatin (not vegan-friendly)
- Requires 2 capsules per full serving
Best for: Anyone wanting a complete relaxation formula without the hassle and expense of buying multiple separate supplements.
5. Swanson Apigenin – Best Budget
Why it stands out: Swanson has been a trusted name in supplements since 1969, and their apigenin offers reliable quality at the lowest price point in this roundup. At around $12-13 for 90 capsules, it’s virtually unbeatable for budget-conscious shoppers who still want a reputable brand.
The 50mg celery-derived dose provides a gentle introduction to apigenin supplementation. Swanson uses celery as their apigenin source rather than the more common chamomile, which may appeal to those who’ve had sensitivities to chamomile products. While it lacks the higher purity certifications (98%+) of premium options, Swanson’s manufacturing standards and over five decades of industry experience offer meaningful peace of mind.
The straightforward formula contains just apigenin, microcrystalline cellulose, and a gelatin capsule—no unnecessary fillers or flow agents. For those new to apigenin who want to test whether it works for them before investing in premium products, Swanson represents minimal financial risk with reasonable quality expectations.
Pros:
- Lowest price in the category
- Trusted brand with 50+ year track record
- Celery-derived (alternative source option)
- Gentle 50mg introductory dose
- Simple, clean formula
Cons:
- Lower purity than premium options
- Contains gelatin (not vegan)
- No third-party testing certification displayed
Best for: First-time apigenin users testing the waters, or anyone on a strict supplement budget who values brand heritage.
6. Nutricost Apigenin – Best for Stacking
Why it stands out: Nutricost’s clean, single-ingredient formula with 180 capsules makes it ideal for those building a custom sleep stack. Their straightforward approach—50mg of pure apigenin with nothing else—gives you complete control over your supplementation protocol without redundant ingredients.
If you’re already taking magnesium threonate and L-theanine separately (or plan to build the popular Huberman sleep stack piece by piece), Nutricost lets you add apigenin without doubling up on any ingredients. This modular approach allows precise dosing adjustments—you can easily take 50mg, 100mg, or 150mg depending on your needs without being locked into a predetermined ratio.
The vegan, gluten-free formula undergoes third-party testing in ISO-accredited laboratories, providing independent verification of purity and potency. The 180-capsule count delivers a full 6-month supply at one capsule daily, or 3 months if you prefer the 100mg dose. Nutricost has built a reputation for no-nonsense supplements at fair prices, and their apigenin exemplifies this philosophy.
Pros:
- Pure, single-ingredient formula for stacking flexibility
- 6-month supply (180 capsules)
- Vegan and gluten-free
- ISO-accredited third-party lab testing
- Simple, transparent labeling
Cons:
- No added synergistic ingredients
- Basic packaging and branding
- Requires separate purchases for stack components
Best for: Methodical supplement stackers who want precise control over each ingredient in their sleep protocol, or those already taking L-theanine and magnesium separately.
7. Native Nature Apigenin + L-Theanine – Best High-Potency Combo
Why it stands out: Native Nature packs 100mg apigenin and 400mg L-theanine per serving—double the apigenin and quadruple the L-theanine of most combination formulas. This is the highest-potency relaxation combo widely available for those who need stronger support.
The chamomile-derived apigenin pairs with a substantial L-theanine dose that rivals dedicated L-theanine supplements. This combination was specifically designed for people who’ve tried standard-dose products without adequate results—the higher potency targets those with more stubborn sleep issues or higher tolerance to calming supplements.
Made in the USA with no fillers, GMOs, soy, gluten, or artificial ingredients, Native Nature emphasizes clean formulation. The 120-capsule bottle provides 60 servings (2 capsules per serving), making it a 2-month supply. While the higher potency commands a premium price, it may prove more economical than taking multiple lower-dose products.
Pros:
- Highest-potency combination formula available
- Substantial 400mg L-theanine per serving
- Clean, filler-free formulation
- Made in USA with quality controls
- Designed for those needing stronger support
Cons:
- May be too strong for sensitive users or beginners
- Higher price point than standard-dose options
- Requires 2 capsules per full serving
Best for: Those who haven’t responded adequately to standard 50mg apigenin supplements, or anyone wanting maximum relaxation support in a convenient combo formula.
8. aSquared Nutrition Apigenin + L-Theanine – Best for Beginners
Why it stands out: aSquared’s moderate 50mg apigenin with 200mg L-theanine in a single capsule makes it the most convenient and beginner-friendly option available. One capsule provides meaningful relaxation benefits without the risk of overwhelming first-time users.
The carefully calibrated formula delivers enough of each ingredient to produce noticeable effects while maintaining a gentle enough profile for those new to sleep supplements. Third-party tested in GMP-certified facilities, the formula comes in an opaque blue bottle with an added desiccant to preserve freshness and prevent oxidation—thoughtful details that demonstrate attention to product quality.
The 120-capsule supply lasts a full 4 months at one capsule daily, providing ample time to assess how apigenin works for your individual sleep patterns. The vegan-friendly, soy-free, gluten-free formula suits most dietary requirements. For anyone curious about apigenin but uncertain about committing to high-dose products, aSquared provides an ideal entry point.
Pros:
- Convenient one-capsule-per-day dosing
- Balanced, beginner-friendly potency
- 4-month supply at recommended dose
- Thoughtful packaging (opaque bottle, desiccant)
- Vegan and allergen-free
Cons:
- Lower potency may not suit experienced users
- Smaller brand with less market recognition
- May require upgrading for stronger effects
Best for: First-time apigenin users who want a gentle, synergistic introduction without committing to high-potency formulas.
9. Beam Dream Sleep Powder – Best Sleep Blend
Why it stands out: Beam takes a comprehensive multi-ingredient approach, combining apigenin with L-theanine, reishi mushroom, magnesium, and other sleep-supporting compounds in a delicious powder format. It’s the most complete sleep formula featuring apigenin as a key ingredient.
The hot cocoa-style powder dissolves easily in water or milk, creating a soothing bedtime ritual that goes beyond pill-popping. This ritualistic aspect of preparing and drinking a warm beverage may itself signal sleep readiness to your brain, complementing the formula’s pharmacological effects. Reishi mushroom adds adaptogenic benefits for stress resilience, while magnesium supports muscle relaxation and GABA function.
Third-party tested and non-GMO, Beam Dream has cultivated a devoted following among wellness enthusiasts who appreciate its taste and effectiveness. The 30-serving pouch makes it pricier per serving than capsule options, but the multi-ingredient formula and enjoyable consumption experience justify the premium for many users. Available in multiple flavor options including cinnamon cocoa.
Pros:
- Multi-ingredient comprehensive formula
- Enjoyable powder format creates bedtime ritual
- Includes reishi mushroom and magnesium
- Third-party tested, non-GMO
- Pleasant taste profile
Cons:
- Higher cost per serving than capsules
- Exact apigenin dose not prominently specified
- Only 30 servings per pouch
- Requires preparation (mixing with liquid)
Best for: Those who want an all-in-one sleep drink experience with multiple synergistic ingredients, or anyone who dislikes swallowing capsules.
10. Stacked Lab Apigenin + L-Theanine – Best Melatonin-Free Alternative
Why it stands out: Stacked Lab positions their formula specifically as a melatonin alternative, combining apigenin with L-theanine for those who’ve experienced grogginess, vivid dreams, or dependency concerns with melatonin-based sleep supplements.
The melatonin-free approach appeals to a growing segment of sleep supplement users who want to support their natural sleep-wake cycle rather than override it with exogenous hormones. Many people find melatonin effective initially but experience diminishing returns or next-day drowsiness over time—apigenin offers an alternative pathway to relaxation that doesn’t interfere with your body’s own melatonin production.
The combination targets relaxation pathways (GABA receptors and alpha brain waves) without affecting circadian hormone regulation, making it suitable even for daytime use when you want calm without sedation. The 60-capsule bottle provides a 1-2 month supply depending on serving size. As a newer brand, Stacked Lab has less track record than established players, but their focused positioning resonates with melatonin-skeptical consumers.
Pros:
- Designed specifically as melatonin replacement
- Clean apigenin + L-theanine combination
- Supports natural sleep mechanisms without hormones
- Suitable for daytime calm (lower doses)
- Clear brand positioning and messaging
Cons:
- Smaller bottle size than competitors
- Newer brand with limited track record
- Premium pricing for bottle size
Best for: Anyone looking to transition away from melatonin, those who’ve experienced melatonin side effects, or people wanting hormone-free sleep support that works with their body’s natural rhythms.
What is Apigenin and Who Should Take It?
Apigenin is a natural flavonoid found most abundantly in chamomile flowers, as well as parsley, celery, oregano, and other plants and herbs. It belongs to a class of compounds called bioflavonoids, which are known for their antioxidant and anti-inflammatory properties. What makes apigenin particularly interesting for sleep is its mechanism of action: it binds to benzodiazepine receptors in the brain, activating chloride ion channels that calm neuronal activity in the forebrain.
This calming effect happens without the sedation, cognitive impairment, or dependency risks associated with actual benzodiazepine medications. Research published in 2024 found that flavonoid polyphenols like apigenin led to measurable improvements in sleep quality among study participants. Animal studies have shown apigenin increases total sleep duration and reduces sleep latency (the time it takes to fall asleep), while also demonstrating neuroprotective effects.
Beyond sleep, apigenin has attracted attention in the longevity community because it inhibits CD38, an enzyme that depletes NAD+—a crucial coenzyme involved in cellular energy and aging. This dual benefit makes apigenin appealing for those interested in both better sleep and healthy aging.
Apigenin is particularly suited for people who find melatonin ineffective, experience strange dreams from melatonin, or wake up groggy after taking it. Those with high cortisol levels, racing thoughts at bedtime, anxiety-related sleep difficulties, or trouble transitioning from wakefulness to sleep often report the most benefit from apigenin supplementation. It’s also popular among shift workers and frequent travelers who want sleep support without disrupting their natural circadian rhythm.
How to Choose the Right Apigenin Supplement
Key Ingredients to Look For
Pure apigenin supplements should contain 50-100mg per serving for sleep support, with some users benefiting from doses up to 200mg. Purity matters significantly—look for products standardized to 98% or higher apigenin content, which indicates better extraction and fewer inactive compounds. Chamomile-derived apigenin is most common, but grapefruit-derived options exist for those who prefer alternative sources.
Many effective sleep formulas combine apigenin with L-theanine (100-400mg), an amino acid from green tea that amplifies calming effects through complementary mechanisms. While apigenin works on GABA receptors, L-theanine promotes alpha brain wave activity associated with relaxed alertness and smooth transitions to sleep. Magnesium threonate is another excellent pairing, as it crosses the blood-brain barrier effectively and supports cognitive recovery during sleep.
Forms Compared
Capsules dominate the apigenin market for good reason—they offer precise dosing, excellent shelf stability, and easy incorporation into existing supplement routines. Most capsules should be taken 30-60 minutes before bed with a small amount of fat (apigenin is fat-soluble) for optimal absorption.
Powders like Beam Dream provide potentially faster absorption and can be incorporated into bedtime routines as warm beverages, creating a ritualistic aspect that may further signal sleep readiness to your brain. The downside is less precise dosing and shorter shelf life once opened.
Gummies exist but typically contain lower apigenin doses and added sugars that may not align with sleep-optimization goals. Liposomal formulas claim enhanced absorption but come at premium prices with limited evidence of superiority for apigenin specifically.
What to Avoid
Steer clear of products that don’t specify apigenin content, listing only vague terms like “chamomile extract” without standardization percentages. These products may contain minimal active apigenin. Avoid formulas loaded with proprietary blends that hide individual ingredient amounts—you should know exactly how much apigenin you’re getting.
Products sourced from grapefruit may interact with medications metabolized by CYP3A4 enzymes (a common drug metabolism pathway), so check with your doctor if you’re taking prescription medications. Also watch for unnecessary fillers, artificial colors, and flow agents that some budget manufacturers include.
Side Effects and Precautions
Apigenin is generally well-tolerated with an excellent safety profile, which makes sense given its long history in the human diet through chamomile tea and common vegetables. The most common effect is mild drowsiness—which is typically the desired outcome for sleep support. Some users report stomach upset at higher doses (above 100mg), which can usually be minimized by taking apigenin with food or a fat source to improve absorption and reduce GI irritation.
At very high doses, apigenin can cause muscle relaxation and increased sedation, so start conservatively and increase gradually. Taking more than 200mg is rarely necessary and may increase side effect risk without proportional benefits.
Those taking blood thinners (apigenin has mild antiplatelet effects), sedatives, benzodiazepines, or medications metabolized by CYP enzymes should consult a healthcare provider before supplementing. The grapefruit-derived versions warrant extra caution for those on prescription medications due to potential drug interactions. Pregnant and nursing women should avoid apigenin supplements due to limited safety data in these populations, even though dietary apigenin from foods is generally considered safe.
FAQs
How much apigenin should I take for sleep?
Most research and anecdotal reports suggest 50-100mg taken 30-60 minutes before bed provides optimal sleep benefits. Start with 50mg to assess your individual response and tolerance, then increase to 100mg if needed after a week or two. Some people benefit from doses up to 200mg, but this is rarely necessary and may increase the risk of excessive sedation or next-day grogginess without proportional benefits.
Can I take apigenin every night?
Yes, apigenin is non-habit-forming and doesn’t disrupt natural sleep architecture the way some sleep aids can. Unlike melatonin, which directly supplies a hormone your body produces naturally, apigenin works by modulating receptor activity—it doesn’t suppress your body’s own melatonin production or create tolerance over time. This makes it suitable for consistent nightly use as part of a long-term sleep optimization strategy.
How long does apigenin take to work?
Most people notice calming effects within 30-60 minutes of taking apigenin, which is why timing it 30-60 minutes before your target bedtime works well. However, the full benefits for overall sleep quality—including easier sleep onset, fewer nighttime wakeups, and better sleep depth—often develop over 1-2 weeks of consistent use as your body adapts to the compound’s effects on GABA receptors and stress hormone levels.
Does apigenin cause grogginess the next morning?
Unlike melatonin, which often leaves users feeling groggy or mentally foggy the next morning, apigenin typically clears the system without residual sedation when taken at recommended doses (50-100mg). Its mechanism of action supports natural relaxation pathways rather than forcing sedation, and its relatively short half-life means the compound has largely been metabolized by morning. However, doses above 150-200mg may produce lingering drowsiness in some individuals.
Can I stack apigenin with magnesium and L-theanine?
Yes, this three-ingredient combination—popularized by Stanford neuroscientist Andrew Huberman—is considered one of the most effective natural sleep stacks available. The typical protocol involves 50-100mg apigenin, 200-400mg L-theanine, and 300-400mg magnesium threonate (or magnesium glycinate as an alternative), all taken 30-60 minutes before bed. Each ingredient targets different aspects of sleep: magnesium supports nervous system relaxation and GABA function, L-theanine promotes alpha brain waves and reduces mental chatter, and apigenin calms neuronal activity while lowering cortisol.
Is apigenin safe for long-term use?
Current evidence suggests apigenin is safe for long-term supplementation in healthy adults. As a naturally occurring compound found abundantly in common foods like chamomile tea, parsley, and celery, it has a long history of human consumption without significant adverse effects reported. That said, long-term clinical trials specifically examining isolated apigenin supplements (rather than whole food sources) remain limited. If you plan to use apigenin indefinitely, periodic breaks or consultation with a healthcare provider is reasonable.
What’s the difference between chamomile extract and pure apigenin?
Chamomile extract contains apigenin as one of many active compounds, but typically at much lower concentrations—standardized chamomile extracts often contain only 1-3% apigenin. Pure apigenin supplements (standardized to 98%+) deliver a concentrated dose of this specific flavonoid without the other chamomile compounds. For targeted sleep support, pure apigenin generally provides more consistent and potent effects, while chamomile extract may offer broader (but milder) benefits from its full spectrum of compounds.
Final Verdict
For most people seeking better sleep through apigenin supplementation, Toniiq Ultra High Strength Apigenin offers the best combination of potency, purity, and long-term value. Its industry-leading 98%+ purity and 100mg dose deliver reliable, consistent results night after night, while the 180-capsule bottle provides a 6-month supply that keeps the cost per serving remarkably low. The rigorous third-party testing and GMP-certified manufacturing add confidence that you’re getting exactly what the label promises.
Budget-conscious shoppers will find excellent value in Swanson Apigenin or Double Wood Apigenin, both offering quality products under $25 per bottle. Swanson’s five-decade reputation and rock-bottom pricing make it ideal for first-timers, while Double Wood’s vegan formula and transparent testing appeal to quality-focused value seekers.
For those wanting a synergistic formula that combines apigenin with complementary ingredients, NatureBell Apigenin + L-Theanine provides the best combo value with its massive 240-capsule supply and well-balanced ingredient ratio. The combination approach often outperforms single-ingredient formulas for sleep support.
Athletes, competitive fitness enthusiasts, and anyone requiring certified purity should strongly consider Momentous Apigenin despite its higher price point. The NSF Certified for Sport designation is exceedingly rare in the apigenin category and provides meaningful assurance for those subject to testing or simply demanding the highest manufacturing standards.
Whichever product you choose, remember that apigenin works best as part of a comprehensive sleep hygiene approach—combining supplementation with consistent sleep schedules, limited evening screen time, and a cool, dark sleeping environment will maximize your results.
