Best Dog Immune Support Supplements (2026) – Top 10 Reviewed
A strong immune system helps your dog fight off infections, recover faster from illness, and maintain overall health throughout their life. Whether your pup is dealing with seasonal challenges, recovering from surgery, or simply needs daily wellness support, immune supplements can provide targeted nutritional backing.
The best dog immune supplements combine proven ingredients like colostrum, probiotics, mushroom extracts, and antioxidant vitamins at effective doses. Here are our top 10 picks for 2026.
| Product | Key Ingredients | Count | Form | Best For |
|---|---|---|---|---|
| VetriScience Liver Health Chews | Milk Thistle, SAMe, Curcumin | 60 | Chews | Best Overall |
| Turkey Tail Mushroom for Dogs | Turkey Tail, Reishi, Lion’s Mane | 170 | Chews | Best Value |
| Human-Grade Superfood Greens | Spirulina, Chlorella, Probiotics | 3.5 oz | Powder | Best Premium |
| STRELLALAB Probiotics + Enzymes | 6 Probiotic Strains, Enzymes | 180 | Chews | Best for Gut-Immune Health |
| VetriScience Extra Strength Gut Health | 7.5 Billion CFU Probiotics | 180 | Capsules | Best High-Potency Probiotic |
| Bully Max 2-in-1 Puppy Treats | Vitamins, Minerals, DHA | 75 | Soft Chews | Best for Puppies |
| Allergy Relief Dog Chews | Colostrum, Omega-3, Probiotics | 120 | Chews | Best for Allergy-Prone Dogs |
| Mushroom Supplement 13-Blend | 13 Organic Mushrooms, MSM | 90 | Chews | Best Mushroom Formula |
| Eye Vitamins for Dogs | Lutein, Lycopene, Vitamin C | 180 | Soft Chews | Best for Eye + Immune Health |
| Liquid L-Lysine Drops | L-Lysine, Taurine | 4 oz | Liquid | Best Budget Option |
1. VetriScience Veterinary Strength Liver Health Chews – Best Overall
Why it stands out: This veterinarian-formulated supplement targets liver health while providing comprehensive immune support through powerful antioxidants and detoxification compounds.
VetriScience combines milk thistle (silymarin), SAMe, and curcumin—three clinically studied ingredients that support both liver function and immune response. The liver plays a critical role in filtering toxins and supporting immune health, making this a smart choice for dogs needing detox support or recovering from medications. Each chew delivers therapeutic doses without requiring fasting, and most dogs readily accept the flavor.
Pros:
- Veterinarian-formulated with clinical-strength ingredients
- Supports liver detoxification and immune function simultaneously
- No fasting required before administration
- Made by a trusted brand with decades of veterinary experience
Cons:
- Premium price point compared to basic immune supplements
Best for: Dogs on long-term medications, senior dogs with liver concerns, or any dog needing comprehensive detox and immune support.
2. Turkey Tail Mushroom for Dogs – Best Value
Why it stands out: This 170-count formula delivers a potent blend of immune-supporting medicinal mushrooms at an excellent price per serving, making daily supplementation affordable.
Turkey tail mushroom has been studied extensively for its beta-glucan content, which helps modulate immune response. This formula combines turkey tail with lion’s mane, reishi, and other functional mushrooms for multi-system support covering immunity, digestion, skin health, and cognitive function. The chicken-flavored chews are palatable for most dogs, and the 170-count bag provides excellent value for daily use.
Pros:
- Contains multiple immune-supporting mushroom varieties
- 170 chews per bag offers great value
- Supports immunity, gut health, and cognitive function
- Made in the USA
Cons:
- Some picky eaters may need the chews hidden in food
Best for: Pet parents seeking affordable daily immune support with the added benefits of medicinal mushrooms.
3. Human-Grade Superfood Greens Powder – Best Premium
Why it stands out: This premium greens powder uses human-grade ingredients including spirulina, chlorella, and probiotics for comprehensive immune and whole-body support.
Unlike typical dog supplements, this formula meets human-grade quality standards. The nutrient-dense blend includes superfoods like spirulina and chlorella that provide antioxidants, chlorophyll, and immune-supporting compounds. It also addresses dental health, gut health, allergies, and joint support—making it a true all-in-one option. The powder format mixes easily into wet or dry food.
Pros:
- Human-grade quality ingredients
- Addresses multiple health concerns beyond immunity
- Powder format allows precise dosing by weight
- No artificial additives or fillers
Cons:
- Higher price than standard chew supplements
- Powder may not suit all dogs or feeding routines
Best for: Health-conscious pet parents wanting premium, whole-food-based immune support for their dogs.
4. STRELLALAB Dog Probiotics + Enzymes – Best for Gut-Immune Health
Why it stands out: Since 70-80% of immune cells reside in the gut, this probiotic and enzyme formula targets immune health at its source with a 180-count supply.
This formula combines six probiotic strains with digestive enzymes to support a healthy gut microbiome—the foundation of strong immunity. It helps with gas, diarrhea, and upset stomach while building immune resilience from within. The chicken-flavored chews are easy to administer, and the large 180-count bag means you won’t need to reorder frequently.
Pros:
- Targets gut health to support overall immunity
- Includes digestive enzymes for better nutrient absorption
- 180 chews provide extended supply
- Helps reduce gas, bloating, and digestive upset
Cons:
- Results may take 2-4 weeks to become noticeable
Best for: Dogs with sensitive stomachs, frequent digestive issues, or those needing gut-based immune support.
5. VetriScience Extra Strength Gut Health – Best High-Potency Probiotic
Why it stands out: With 7.5 billion CFU per capsule, this is one of the most potent probiotic options available for dogs needing serious immune and digestive support.
VetriScience’s extra-strength formula delivers a mega-dose of beneficial bacteria along with prebiotics to feed those good bacteria. The easy-open capsules can be given whole or sprinkled on food, offering flexibility for picky eaters. This high-potency option is particularly useful for dogs recovering from antibiotics, dealing with chronic digestive issues, or needing intensive immune support.
Pros:
- 7.5 billion CFU provides therapeutic-level probiotic support
- Includes prebiotics for sustained gut health
- Versatile capsule format (swallow whole or sprinkle)
- Suitable for both dogs and cats
Cons:
- Capsule format may be less convenient than chews for some dogs
Best for: Dogs recovering from illness or antibiotics, those with chronic digestive issues, or any dog needing maximum-strength probiotic support.
6. Bully Max 2-in-1 Puppy Treats – Best for Puppies
Why it stands out: Specifically formulated for growing puppies, these soft chews support immune development alongside healthy growth with essential vitamins and DHA.
Puppies have developing immune systems that need targeted nutritional support. This formula provides essential vitamins, minerals, and DHA for brain development while building immune resilience during those crucial first months. The soft chew format is gentle on puppy teeth and gums, and the palatable flavor makes daily supplementation easy for small, medium, and large breed puppies.
Pros:
- Specifically designed for puppy immune and growth needs
- Contains DHA for brain development
- Soft texture is easy on puppy teeth
- Suitable for all puppy sizes
Cons:
- Not formulated for adult dogs (consider switching after puppyhood)
Best for: Puppies of all breeds who need immune support during their critical developmental period.
7. Allergy Relief Dog Chews with Colostrum – Best for Allergy-Prone Dogs
Why it stands out: This triple-action formula combines colostrum, omega-3s, and probiotics to support immune balance specifically for dogs dealing with seasonal or environmental allergies.
Colostrum is nature’s first immune booster, packed with antibodies and immune factors. Combined with omega-3 fatty acids for inflammation support and probiotics for gut health, this formula addresses the root causes of allergic responses rather than just symptoms. The 120 chews provide a 2-4 month supply depending on dog size, and the chicken flavor appeals to most dogs.
Pros:
- Colostrum provides natural immune-balancing factors
- Omega-3s help reduce inflammatory responses
- Probiotics support gut-immune connection
- Made in the USA
Cons:
- May need 4-6 weeks of consistent use to see full allergy relief
Best for: Dogs with seasonal allergies, environmental sensitivities, or recurring skin and coat issues related to immune imbalance.
8. 13-in-1 Organic Mushroom Supplement – Best Mushroom Formula
Why it stands out: This comprehensive formula includes 13 organic mushroom varieties plus MSM for joint support, delivering broad-spectrum immune modulation.
Medicinal mushrooms like turkey tail, reishi, lion’s mane, and chaga each offer unique immune benefits. This formula combines all 13 varieties for synergistic effects, plus adds glucosamine and MSM for joint support—making it ideal for dogs who need both immune and mobility help. The chicken-flavored chews are made in the USA with organic mushroom ingredients.
Pros:
- 13 different organic mushroom varieties
- Added joint support with MSM and glucosamine
- Supports immunity, gut, skin, and cognitive health
- Organic mushroom sourcing
Cons:
- Contains joint ingredients some dogs may not need
Best for: Dogs who would benefit from comprehensive mushroom-based immune support, especially senior dogs also needing joint help.
9. Eye Vitamins for Dogs – Best for Eye + Immune Health
Why it stands out: This unique formula supports eye health with lutein and lycopene while providing immune-boosting vitamin C and antioxidants for dual-purpose benefits.
The eyes are often overlooked when it comes to immune support, but antioxidants like lutein, lycopene, and vitamin C protect against oxidative stress throughout the body. This 180-count formula supports clear vision, helps reduce tear stains, and provides whole-body antioxidant protection. It’s suitable for dogs of all breeds and ages, making it versatile for multi-dog households.
Pros:
- Dual-purpose eye and immune support
- 180 soft chews provide excellent value
- Contains powerful antioxidants (lutein, lycopene, vitamin C)
- Suitable for all breeds and ages
Cons:
- Primary focus is eye health; dogs without eye concerns may prefer a different formula
Best for: Dogs prone to eye issues, tear staining, or those needing antioxidant-based immune support.
10. Liquid L-Lysine Drops – Best Budget Option
Why it stands out: This affordable liquid formula delivers L-lysine and taurine for immune and respiratory support, with easy dosing for dogs of any size.
L-lysine is an essential amino acid that supports immune function, particularly for respiratory health. This chicken-flavored liquid makes dosing simple—just add drops to food based on your dog’s weight. The larger 4 oz bottle provides excellent value, and the liquid format is perfect for picky eaters who reject chews or pills.
Pros:
- Budget-friendly price point
- Liquid format allows precise weight-based dosing
- Supports respiratory and immune health
- Chicken flavor for easy acceptance
Cons:
- Fewer ingredients than comprehensive chew formulas
- Requires refrigeration after opening
Best for: Pet parents seeking affordable, targeted immune support, especially for dogs with respiratory concerns or those who won’t take chews.
How to Choose the Right Immune Supplement for Your Dog
Key Ingredients to Look For
The most effective immune supplements contain proven ingredients like probiotics (which support gut-based immunity), colostrum (rich in antibodies and immune factors), medicinal mushrooms (turkey tail, reishi, and lion’s mane for immune modulation), and antioxidants (vitamins C and E, lutein, and beta-carotene). Look for products that list specific strains and CFU counts for probiotics, or standardized extracts for herbal ingredients.
Size & Breed Considerations
Most immune supplements are dosed by weight, so follow package instructions carefully. Small dogs need fewer chews or smaller doses than large breeds. Some products are specifically formulated for puppies, seniors, or dogs with particular health concerns—choose accordingly.
Form Factor: Chews vs Capsules vs Powder vs Liquid
Soft chews are the most popular format due to easy administration and palatability. Capsules offer higher potency but may need to be hidden in food. Powders allow precise dosing and mix into meals easily. Liquids work well for picky eaters and very small dogs. Choose based on your dog’s preferences and your daily routine.
What to Avoid
Skip supplements with artificial colors, flavors, or preservatives. Avoid vague ingredient lists that don’t specify amounts or strains. Be wary of products making unrealistic health claims or those manufactured outside the USA without quality certifications.
Signs Your Dog May Need Immune Support
- Frequent infections: Recurring ear infections, skin infections, or respiratory issues may indicate a weakened immune system.
- Slow wound healing: Cuts, scrapes, or surgical incisions that take longer than expected to heal.
- Chronic allergies: Persistent itching, hot spots, or seasonal allergies that don’t respond well to other treatments.
- Low energy or lethargy: Unusual tiredness or lack of enthusiasm for normal activities.
- Digestive issues: Frequent upset stomach, diarrhea, or poor appetite can signal gut-immune imbalance.
- Recovery from illness: Dogs bouncing back from surgery, infections, or long-term medications often benefit from immune support.
- Senior dogs: Aging naturally weakens immune function, making supplementation valuable for older pets.
If your dog shows persistent symptoms, consult your veterinarian to rule out underlying conditions before starting supplements.
Side Effects and Safety
Most immune supplements are well-tolerated, but introduce any new supplement gradually over 7-10 days to avoid digestive upset. Start with half the recommended dose and work up to full dosing. Common mild side effects include temporary loose stools or changes in appetite, which typically resolve as your dog adjusts.
Consult your veterinarian before starting immune supplements if your dog has autoimmune conditions, is on immunosuppressive medications, or is pregnant or nursing. Some ingredients may interact with medications, so always disclose all supplements to your vet.
FAQs
How long does it take for immune supplements to work?
Most dogs show improvement within 2-4 weeks of consistent use, though some benefits (like reduced infection frequency) may take 1-2 months to become apparent. Probiotics often show digestive benefits faster than other immune ingredients.
Can I give my dog immune supplements with other vitamins?
Yes, most immune supplements can be combined with other vitamins, but avoid doubling up on the same ingredients. If your multivitamin already contains probiotics or certain antioxidants, choose an immune supplement with complementary ingredients.
Are immune supplements safe for puppies?
Many immune supplements are safe for puppies over 8-12 weeks old, but choose products specifically formulated for puppies when possible. Always follow age and weight guidelines on the packaging, and consult your vet for very young puppies.
Do dogs with allergies need immune supplements?
Dogs with allergies often benefit from immune-balancing supplements, particularly those containing colostrum, omega-3s, and probiotics. These ingredients help modulate the immune response rather than suppressing it, addressing the root cause of allergic reactions.
Should I give immune supplements year-round or seasonally?
For general wellness, year-round supplementation provides consistent support. Dogs with seasonal allergies may benefit from increased dosing during problem months. Senior dogs and those with chronic health issues typically do best with continuous supplementation.
Can immune supplements replace veterinary care?
No—supplements support health but don’t replace proper veterinary diagnosis and treatment. If your dog has recurring infections, chronic illness, or concerning symptoms, see your vet first to identify underlying causes.
Final Verdict
For comprehensive immune support, VetriScience Liver Health Chews offers the best combination of veterinarian-formulated ingredients and proven efficacy—particularly for dogs needing detox support or recovering from medications.
Pet parents on a budget should consider the Turkey Tail Mushroom chews, which deliver excellent immune-supporting mushroom compounds at a fraction of the cost of premium options. For puppies, Bully Max 2-in-1 Puppy Treats provide age-appropriate immune and developmental support.
Dogs with allergies or sensitive systems will benefit most from the Allergy Relief Chews with Colostrum, while those needing maximum probiotic support should try VetriScience Extra Strength Gut Health with its 7.5 billion CFU formula.
