10 Best Niacin (B3) Supplements (2026) Reviewed
Vitamin B3, commonly known as niacin, is an essential nutrient that plays a crucial role in energy metabolism, nervous system function, and cellular health. With more than 400 enzymes requiring niacin-derived coenzymes (NAD and NADP) to catalyze reactions in the body, it’s one of the most metabolically important vitamins.
Choosing the right niacin supplement can be confusing. The vitamin exists in several forms—nicotinic acid (traditional niacin), niacinamide (nicotinamide), and inositol hexanicotinate—each with distinct properties and applications. Some forms cause the famous “niacin flush” (a temporary warming and reddening of the skin), while others are completely flush-free. Some support healthy cholesterol levels, while others focus on energy and skin health.
We researched top-selling niacin supplements on Amazon, consulted third-party testing resources like ConsumerLab, and reviewed brand specifications to bring you this comprehensive guide. Whether you’re looking for flush-free niacinamide for skin health, traditional niacin for cardiovascular support, or an extended-release formula for gradual absorption, we’ve identified the best options for every need.
Table of Contents
- Quick Comparison Table
- Understanding Niacin Forms
- Individual Product Reviews
- Buying Guide
- How to Take Niacin
- Potential Benefits
- Safety Considerations
- FAQ
- Bottom Line
Quick Comparison Table
| Product | Form | Serving Size | Key Differentiator | Best For | Winner |
|---|---|---|---|---|---|
| Thorne Niacinamide | Niacinamide | 500mg (1 capsule) | Third-party tested, minimal excipients | Premium flush-free support | 🏆 TOP PICK |
| Nutricost Niacinamide | Niacinamide | 500mg (1 capsule) | 240 capsules, excellent value | Budget-conscious buyers | 🥇 Best Budget |
| Life Extension No Flush Niacin | Inositol Hexanicotinate | 640mg (1 capsule) | Slow-release IHN formula | Those who want niacin without flush | 🥇 Best IHN |
| Nature’s Bounty Flush Free | Inositol Hexanicotinate | 500mg (1 capsule) | Trusted brand, widely available | Everyday flush-free use | |
| Nutricost Niacin | Nicotinic Acid | 500mg (1 capsule) | Traditional niacin with flush | Those seeking the flush effect | 🥇 Best Traditional |
| NOW Foods Sustained Release | Nicotinic Acid (SR) | 500mg (1 tablet) | Gradual release minimizes flush | Extended absorption | 🥇 Best Extended |
| Pure Encapsulations Niacinamide | Niacinamide | 1000mg (2 capsules) | Hypoallergenic, free from common allergens | Sensitive individuals | 🥇 Best Hypoallergenic |
| Pure Encapsulations Niacitol | Inositol Nicotinate | 500mg (1 capsule) | Professional-grade, clean formula | Practitioner-recommended | |
| Solgar Niacin 500mg | Nicotinic Acid | 500mg (1 capsule) | 75+ year legacy brand, glass bottles | Cardiovascular support | |
| Dr. Berg Niacin | Nicotinic Acid | 500mg (1 capsule) | 100-day supply, cGMP certified | Heart and energy support |
Note: Product details may change. Always verify current information on Amazon before purchasing.
Understanding Niacin Forms: Which Type Is Right for You?
Before diving into individual products, it’s important to understand the three main forms of vitamin B3 supplements, as they have significantly different properties and uses.
Nicotinic Acid (Traditional Niacin)
Pros: The only form of B3 that has been studied for supporting healthy cholesterol levels. Research suggests it may help raise HDL (“good”) cholesterol and lower triglycerides and LDL (“bad”) cholesterol when taken in therapeutic doses under medical supervision.
Cons: Causes the “niacin flush”—a temporary but often intense warming, reddening, and tingling of the skin that occurs 15-30 minutes after taking. While harmless, many find it uncomfortable. Higher doses require medical monitoring for liver function.
Best for: Those seeking traditional niacin effects, individuals who don’t mind (or actually prefer) the flush sensation, and those working with healthcare providers on cardiovascular support protocols.
Niacinamide (Nicotinamide)
Pros: Completely flush-free. Supports cellular energy production, joint health, and skin health. Some research suggests it may help protect against certain types of skin concerns. Generally well-tolerated at moderate doses.
Cons: Does not have the same lipid-modifying effects as nicotinic acid, so it’s not appropriate for those seeking cholesterol support.
Best for: Those wanting B3 benefits without any flushing, skin health support, joint comfort, and general energy metabolism.
Inositol Hexanicotinate (IHN / “Flush-Free Niacin”)
Pros: Marketed as a way to get niacin’s benefits without the flush. Consists of six niacin molecules bound to an inositol molecule, which releases niacin slowly in the body.
Cons: Some research suggests IHN may not be as bioavailable as nicotinic acid, and it may not provide the same lipid-modifying effects. Results are mixed in clinical studies.
Best for: Those who want to try a niacin-derived formula without flushing and don’t require the specific cardiovascular benefits of pure nicotinic acid.
Individual Product Reviews
Thorne Niacinamide — Best Overall
Thorne Niacinamide stands out as our top pick for its exceptional purity standards, third-party testing, and trusted reputation among healthcare practitioners.
Thorne is widely recognized as a pharmaceutical-grade supplement brand, trusted by professional sports teams and recommended by healthcare practitioners. Their Niacinamide provides 500mg of flush-free vitamin B3 per capsule in a formula free from unnecessary additives. The company’s commitment to third-party testing and transparent manufacturing practices makes this an excellent choice for those who prioritize quality.
Each capsule uses hypromellose (plant-derived cellulose) with only calcium laurate as an additional ingredient—one of the cleanest formulas on the market. Unlike many competitors, Thorne avoids common flow agents like magnesium stearate that some consumers prefer to avoid.
Key Specifications:
- 500mg niacinamide per capsule
- 180 capsules per bottle
- Third-party tested and certified
- Gluten-free, dairy-free
- No artificial preservatives
Considerations: Premium pricing compared to budget brands. However, for those who value pharmaceutical-grade quality and minimal ingredients, the investment is often worthwhile.
Life Extension No Flush Niacin — Best Inositol Hexanicotinate
Life Extension’s formula provides 640mg of niacin from inositol hexanicotinate, offering a flush-free alternative for those who want to try a niacin-derived supplement.
Life Extension has been a trusted name in evidence-based supplementation for decades. Their No Flush Niacin uses inositol hexanicotinate (IHN), a form consisting of six niacin molecules chemically linked to an inositol molecule. This unique structure allows for gradual release in the body, typically avoiding the flush reaction associated with regular niacin.
Each capsule provides 640mg of niacin (from 800mg of inositol hexanicotinate) plus 160mg of inositol. The company is known for rigorous quality standards and scientific backing. While IHN may not provide the same lipid effects as pure nicotinic acid, it remains a popular choice for those wanting a flush-free niacin experience.
Key Specifications:
- 640mg niacin from 800mg inositol hexanicotinate
- 100 capsules per bottle
- Non-GMO, gluten-free
- Manufactured in USA
Considerations: Research on IHN bioavailability is mixed. Some studies suggest it may not raise blood niacin levels as effectively as nicotinic acid. Best for those prioritizing flush avoidance over potential lipid effects.
Nature’s Bounty Flush Free Niacin — Best Value Flush-Free
Nature’s Bounty offers a trusted, widely available flush-free niacin at an accessible price point, making it an excellent choice for everyday supplementation.
With over 50 years in the supplement industry, Nature’s Bounty is one of the most recognizable names in vitamins. Their Flush Free Niacin uses inositol hexanicotinate to deliver 500mg of niacin per capsule without the uncomfortable flushing sensation. The product is gluten-free and contains no artificial flavors or colors.
What makes Nature’s Bounty particularly appealing is its wide availability—you can find it in most drugstores, grocery stores, and online retailers. For those who prefer shopping in person or want a reliable, no-frills option from a trusted brand, this is an excellent choice.
Key Specifications:
- 500mg niacin as inositol hexanicotinate
- 120 capsules per bottle
- Gluten-free
- No artificial flavors or colors
- 50+ year brand legacy
Considerations: Uses gelatin capsules (not suitable for vegetarians/vegans). Like other IHN products, may not provide the same effects as traditional nicotinic acid.
Nutricost Niacin — Best Traditional Niacin (With Flush)
For those who specifically want traditional nicotinic acid with its characteristic flush effect, Nutricost Niacin delivers high-potency at budget-friendly pricing.
Some people actually prefer the niacin flush—viewing it as confirmation the supplement is working or appreciating the warming sensation. Others specifically want nicotinic acid for its unique properties that differ from other B3 forms. Nutricost Niacin delivers 500mg of pure nicotinic acid per capsule in a formula that will definitely produce the flush in most people.
The brand clearly labels this product as causing the flush and recommends starting with half a capsule or taking with food to reduce intensity. With 240 capsules per bottle, it provides excellent value for those committed to traditional niacin supplementation.
Key Specifications:
- 500mg nicotinic acid per capsule
- 240 capsules per bottle
- Non-GMO, gluten-free
- GMP-compliant manufacturing
Considerations: Will cause niacin flush in most people—start with a lower dose and gradually increase. Taking on an empty stomach intensifies the flush. High doses should be monitored by a healthcare provider.
NOW Foods Niacin Sustained Release — Best Extended-Release
NOW Foods’ sustained-release formula gradually releases niacin over time, helping to minimize flush while still using true nicotinic acid.
NOW Foods has been a trusted supplement manufacturer since 1968, known for quality products at reasonable prices. Their Sustained Release Niacin uses a special matrix that gradually releases 500mg of nicotinic acid over several hours, which may help reduce the intensity of flushing compared to immediate-release formulas.
Unlike flush-free forms that use different niacin derivatives, this product contains actual nicotinic acid—just delivered more slowly. This makes it potentially appealing for those who want nicotinic acid’s properties but find immediate-release flush uncomfortable. The 250-tablet bottle provides excellent long-term value.
Key Specifications:
- 500mg nicotinic acid per tablet (sustained release)
- 250 tablets per bottle
- Soy-free, gluten-free, dairy-free
- GMP Quality Assured, A-rated third-party certification
Considerations: Sustained-release niacin has been associated with increased hepatotoxicity risk compared to immediate-release in some studies. Regular liver function monitoring is recommended for long-term, high-dose use. Consult your healthcare provider before use.
Pure Encapsulations Niacinamide — Best Hypoallergenic
For those with sensitivities or allergies, Pure Encapsulations offers the cleanest, most hypoallergenic niacinamide formula on the market.
Pure Encapsulations is the number-one most recommended professional supplement brand among healthcare practitioners for good reason. Their products are rigorously formulated to exclude common allergens and unnecessary additives, making them ideal for sensitive individuals.
Their Niacinamide formula provides 1000mg per two-capsule serving (500mg per capsule) and is free from wheat, eggs, tree nuts, peanuts, gluten, artificial colors, flavors, sweeteners, coatings, GMOs, and unnecessary binders, fillers, and preservatives. This makes it suitable for those with multiple sensitivities who struggle to find clean supplements.
Key Specifications:
- 500mg niacinamide per capsule (1000mg per 2-capsule serving)
- 90 capsules per bottle
- Hypoallergenic—free from 8 major allergens
- Vegetarian capsules
- No unnecessary additives
Considerations: Premium pricing. Smaller bottle size than budget brands. The 2-capsule serving size may be unnecessary for those who only need 500mg daily.
Pure Encapsulations Niacitol — Best Premium Inositol Hexanicotinate
When you want the highest-quality IHN formula with pharmaceutical-grade purity, Pure Encapsulations Niacitol delivers.
Pure Encapsulations brings their trademark hypoallergenic, high-purity approach to inositol hexanicotinate with Niacitol. Each capsule provides 500mg of niacin as inositol nicotinate, offering flush-free B3 support in a clean, professional-grade formula.
Like all Pure Encapsulations products, Niacitol is free from common allergens and unnecessary additives, making it ideal for sensitive individuals who want to try IHN supplementation. The company’s rigorous testing and quality standards ensure you’re getting exactly what’s on the label.
Key Specifications:
- 500mg niacin as inositol nicotinate per capsule
- 120 capsules per bottle
- Hypoallergenic formula
- Vegetarian capsules
- Practitioner-trusted brand
Considerations: Higher cost than budget IHN options. As with other IHN products, may not provide identical effects to pure nicotinic acid.
Solgar Niacin 500mg — Best for Cardiovascular Support
Solgar’s 75+ year legacy and commitment to quality make their traditional niacin formula a trusted choice for those seeking cardiovascular support under medical guidance.
Solgar has been crafting premium supplements since 1947, earning them the tagline “The Gold Standard.” Their Niacin 500mg uses pure nicotinic acid in vegetable capsules, packaged in their signature amber glass bottles that protect against light degradation.
This product is ideal for those working with healthcare providers on cardiovascular support protocols. Solgar recommends starting at low doses and gradually increasing, and they clearly warn about the expected flush effect. The company’s commitment to quality, combined with their vegan-friendly formula, makes this a solid choice for traditional niacin supplementation.
Key Specifications:
- 500mg nicotinic acid per capsule
- 250 vegetable capsules per bottle
- Vegan, kosher, gluten-free
- Amber glass bottles for freshness
- 75+ year brand legacy
Considerations: Will cause niacin flush. Higher doses should only be taken under medical supervision. California Prop 65 warning for lead (common for many supplements).
Dr. Berg Niacin — Best for Tolerance Building
Dr. Berg’s formula now offers 125mg per capsule, allowing users to gradually build niacin tolerance before working up to the full 500mg daily dose.
Dr. Eric Berg is a well-known health educator, and his supplement line reflects his approach to gradual, thoughtful supplementation. The Niacin formula provides 500mg per capsule of pure nicotinic acid, designed for those specifically seeking the traditional niacin experience with its characteristic flush.
Dr. Berg updated this formula to allow for easier tolerance building, with 125mg per capsule so users can start with one capsule and work up to 4 capsules daily. This approach helps minimize the initial intensity of the niacin flush as your body adapts. The 100-capsule bottle provides good value for those committed to a niacin protocol.
Key Specifications:
- 125mg nicotinic acid per capsule (work up to 500mg with 4 capsules)
- 100 capsules per bottle
- cGMP-certified facility
- 30-day money-back guarantee
Considerations: Will cause niacin flush—this is expected and should diminish with consistent use. The lower-dose capsules require taking multiple pills for full 500mg serving.
Buying Guide: What to Look For
Choose the Right Form for Your Goals
- Niacinamide: Best for general B3 benefits, skin health, joint support without any flushing
- Nicotinic Acid: Traditional form studied for cardiovascular support; causes flush
- Inositol Hexanicotinate: Flush-free niacin derivative; effects may differ from nicotinic acid
- Extended-Release Nicotinic Acid: May reduce flush intensity but requires liver monitoring
Quality Indicators
- Third-party testing: Brands like Thorne, Pure Encapsulations, and Life Extension invest in independent verification
- GMP certification: Ensures consistent manufacturing standards
- Minimal additives: Cleaner formulas reduce the risk of reactions
- Transparent labeling: Clear disclosure of the specific B3 form used
Red Flags to Avoid
- Products that don’t specify which form of niacin they contain
- Extremely cheap products from unknown brands without quality certifications
- Proprietary blends that hide individual ingredient amounts
- Products making disease treatment claims (supplements cannot legally make such claims)
How to Take Niacin
Recommended Dosages
The Recommended Dietary Allowance (RDA) for niacin is 16mg for adult men and 14mg for adult women—amounts easily obtained from a balanced diet. Supplemental doses are typically much higher:
- General supplementation: 100-500mg daily
- Higher therapeutic doses: Only under medical supervision
Best Time to Take
- With food: Taking niacin with meals helps reduce the intensity of flushing and minimizes stomach upset
- Consistent timing: Taking niacin at the same time daily may help your body adapt to the flush
- Aspirin trick: Some healthcare providers recommend taking a low-dose aspirin 30 minutes before nicotinic acid to reduce flush intensity (discuss with your doctor first)
Tips for Managing the Niacin Flush
- Start with lower doses and gradually increase
- Take with food, not on an empty stomach
- Avoid hot beverages or alcohol around dosing time
- Be consistent—the flush typically decreases with regular use
- If you truly can’t tolerate the flush, switch to niacinamide or IHN
Potential Benefits of Niacin
Note: The following information is for educational purposes. Niacin supplements are not intended to diagnose, treat, cure, or prevent any disease. Always consult with a healthcare provider before starting supplementation.
Energy Metabolism
Niacin is essential for converting carbohydrates, proteins, and fats into usable energy. As a precursor to NAD and NADP, coenzymes required by more than 400 enzymes, adequate niacin intake supports healthy cellular energy production.
Nervous System Support
B vitamins, including niacin, play important roles in nervous system function. Niacinamide in particular may support cognitive function and has been studied for its potential neuroprotective properties.
Skin Health
Niacinamide has gained significant attention in dermatology. Research suggests it may support skin barrier function, and some studies have explored its role in reducing the risk of certain non-melanoma skin concerns in high-risk individuals.
Cholesterol Support
Nicotinic acid (not niacinamide or IHN) has been studied extensively for its effects on blood lipids. Under medical supervision, high-dose niacin may help raise HDL cholesterol and lower triglycerides. However, recent research has questioned whether these lipid improvements translate to better cardiovascular outcomes, and niacin is no longer a first-line recommendation for most patients.
Joint Comfort
Some research suggests niacinamide may support joint flexibility and comfort, though more studies are needed to confirm these preliminary findings.
Safety Considerations
Potential Side Effects
- Niacin flush: Harmless but uncomfortable warmth, redness, and tingling (nicotinic acid only)
- Gastrointestinal upset: Nausea, stomach discomfort, especially on empty stomach
- Headache and dizziness: May occur, especially at higher doses
- Liver effects: High doses, especially sustained-release formulas, may affect liver function
- Blood sugar changes: High-dose niacin may affect glucose tolerance
Who Should Avoid or Use Caution
- People with liver disease or abnormal liver function tests
- Those with active peptic ulcer disease
- Individuals with gout or hyperuricemia
- People with diabetes (may affect blood sugar control)
- Those taking blood pressure medications (niacin may cause hypotension)
- Pregnant or nursing women (consult healthcare provider first)
Drug Interactions
Niacin may interact with:
- Statins and other cholesterol medications
- Blood pressure medications
- Blood thinners
- Diabetes medications
- Alcohol (may worsen liver effects and flush)
When to Consult a Healthcare Provider
Consult your doctor before taking niacin supplements if you:
- Take any prescription medications
- Have any chronic health conditions
- Are pregnant or breastfeeding
- Plan to take more than 500mg daily
- Experience persistent or severe side effects
Frequently Asked Questions
What’s the difference between niacin and niacinamide?
Both are forms of vitamin B3 that provide essential nutrient activity, but they have different properties. Niacin (nicotinic acid) causes the characteristic flush and has been studied for cardiovascular support. Niacinamide (nicotinamide) is flush-free but doesn’t have the same lipid-modifying effects. Your body can convert between the two forms to some extent.
Is the niacin flush dangerous?
No, the niacin flush is harmless, though it can be uncomfortable. It’s caused by blood vessel dilation and typically lasts 15-30 minutes. The flush usually decreases with regular use as your body adapts. If you find it intolerable, switch to niacinamide or inositol hexanicotinate.
Can I take niacin to lower my cholesterol?
While nicotinic acid has been shown to improve cholesterol numbers, it’s no longer a first-line treatment for most people. Recent clinical trials haven’t consistently shown cardiovascular outcome benefits, and statins remain the preferred option. Never self-treat cholesterol issues—work with your healthcare provider to determine the best approach.
How long does it take for niacin to work?
For general B3 nutrient benefits, niacin is absorbed quickly. The flush occurs within 15-30 minutes of taking nicotinic acid. For potential therapeutic effects (like lipid changes), studies typically use 8-12 week timeframes, though this should only be done under medical supervision.
Should I take niacin in the morning or at night?
Most people prefer taking niacin with their largest meal of the day to minimize flush and stomach upset. Some take it at night so the flush occurs during sleep. There’s no single “best” time—find what works for your schedule and tolerance.
Can I take niacin with other B vitamins?
Yes, niacin is commonly included in B-complex supplements. Taking it with other B vitamins is generally safe, though the doses in B-complex products are typically lower than standalone niacin supplements.
Is flush-free niacin as effective as regular niacin?
It depends on your goals. Niacinamide provides the essential B3 nutrient benefits but lacks nicotinic acid’s lipid effects. Inositol hexanicotinate may have reduced bioavailability compared to nicotinic acid. If you specifically need the cardiovascular effects studied with nicotinic acid, flush-free alternatives may not be equivalent.
How much niacin is too much?
The Tolerable Upper Intake Level (UL) for niacin is 35mg daily for adults from supplements—this threshold is based on the flush side effect. Higher therapeutic doses are used under medical supervision with appropriate monitoring. Taking more than 500mg daily without medical oversight is not recommended.
Can niacin help with skin health?
Research on niacinamide (not nicotinic acid) suggests it may support skin barrier function and is being studied for potential benefits in reducing certain skin concerns. Many dermatologists recommend niacinamide for this purpose, and it’s also popular in topical skincare products.
Is it safe to take niacin every day?
At moderate doses (up to 500mg of niacinamide or lower doses of nicotinic acid), daily use is generally considered safe for most healthy adults. Higher doses or extended-release nicotinic acid require periodic liver function monitoring. Always follow product directions and consult your healthcare provider for personalized guidance.
Bottom Line
For most people: Thorne Niacinamide offers the best combination of quality, purity, and effectiveness for general B3 supplementation without any flush concerns.
For budget-conscious buyers: Nutricost Niacinamide delivers excellent value with solid quality standards at a fraction of premium brand pricing.
For flush-free niacin seekers: Life Extension No Flush Niacin provides a well-formulated inositol hexanicotinate option from a trusted brand.
For traditional niacin with flush: Nutricost Niacin or Solgar Niacin offer quality nicotinic acid for those who want (or don’t mind) the flush effect.
For sensitive individuals: Pure Encapsulations Niacinamide provides the cleanest, most hypoallergenic formula available.
