Best Cat Calming Supplements (2026) – Top 10 Reviewed
Stressed cats can exhibit all kinds of unwanted behaviors, from excessive scratching and hiding to spraying and aggression. Whether your feline is anxious about vet visits, thunderstorms, new environments, or separation, a quality calming supplement can help take the edge off. We’ve reviewed the best cat calming supplements to help your kitty feel more relaxed and at ease.
Our Top Picks at a Glance
- Best Overall: Purina Pro Plan Calming Care – Vet-recommended probiotic-based calming
- Best Value: NaturVet Quiet Moments – Affordable with melatonin and L-tryptophan
- Best Premium: Nutramax Solliquin – L-theanine and magnolia bark for lasting calm
Quick Comparison
| Product | Key Ingredients | Form | Servings | Best For |
|---|---|---|---|---|
| Purina Pro Plan Calming Care | BL999 Probiotic Strain | Powder Packets | 30 | Daily calming via gut-brain axis |
| NaturVet Quiet Moments | L-Tryptophan, Chamomile, Melatonin | Soft Chews | 60 | Budget-friendly occasional calming |
| Nutramax Solliquin | L-Theanine, Magnolia, Phellodendron | Soft Chews | 75 | Daily anxiety management |
| Rocco & Roxie Calming Treats | Ashwagandha, GABA, Melatonin | Crunchy & Creamy Chews | 30 | Stress relief with great taste |
| GNC Pets Advanced Calming Chews | Thiamine, L-Tryptophan, Chamomile | Soft Chews | 60 | Occasional stress situations |
| Zesty Paws Calming Chews for Cats | Ashwagandha, L-Theanine, L-Tryptophan, Chamomile | Soft Chews | 60 | Comprehensive daily calming |
| Vetoquinol Zylkene | Alpha-Casozepine (Milk Protein) | Capsules | 30 | Natural milk-derived calming |
| VetriScience Composure | Colostrum, L-Theanine, Thiamine | Chews | 30 | Fast-acting situational calming |
| Zesty Paws Calming Mousse | L-Theanine, Ashwagandha, Valerian Root | Mousse Tubes | 14 | Cats who refuse chews |
1. Purina Pro Plan Calming Care – Best Overall
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This innovative probiotic-based calming supplement works through the gut-brain connection to promote lasting relaxation.
Purina Pro Plan Veterinary Supplements Calming Care takes a unique approach to feline anxiety by using a specific probiotic strain, BL999, that has been shown to help cats maintain calm behavior. Rather than relying on sedative-like herbs, this supplement works through the gut-brain axis to promote a balanced, relaxed state. Each box contains 30 individually portioned powder packets.
Simply sprinkle one packet on your cat’s food daily. The unflavored powder blends seamlessly with both wet and dry food, making it ideal for picky eaters. Results typically appear within 6 weeks of consistent daily use.
What We Like
- Science-backed probiotic approach to calming
- Unflavored powder mixes easily with any food
- No sedative ingredients – promotes natural calm behavior
What Could Be Better
- Takes up to 6 weeks for full effects to appear
- Not ideal for acute, situational anxiety needs
Bottom Line: For cats with ongoing anxiety issues, Purina Calming Care offers a scientifically innovative approach that addresses stress at its source.
2. NaturVet Quiet Moments – Best Value
- Made in USA
- For use in cats over the age of 12 weeks.
- Our unique blend of thiamine and L-tryptophan help reduce stress and tension.
- Ginger supports sensitive stomachs which is especially important when traveling, while melatonin helps to promote rest and relaxation.
An affordable, go-to calming chew with melatonin and L-tryptophan that works quickly for stressful situations.
NaturVet Quiet Moments combines L-tryptophan, chamomile, thiamine, ginger, and a touch of melatonin to help your cat relax during stressful events. The formula promotes rest and relaxation while ginger supports sensitive stomachs, which is especially helpful when traveling. These soft chews are suitable for cats over 12 weeks of age.
At 60 chews per container and a budget-friendly price, Quiet Moments delivers excellent value. They’re perfect for occasional use before vet visits, car rides, or thunderstorms.
What We Like
- Affordable price with 60 chews per container
- Ginger inclusion helps with travel-related nausea
- Works within 30 minutes for situational calming
What Could Be Better
- Melatonin dose is very low (0.01mg per 2 chews)
- Not designed for daily long-term anxiety management
Bottom Line: Quiet Moments is an excellent budget-friendly option for occasional stressful situations like travel, vet visits, and storms.
3. Nutramax Solliquin – Best for Daily Anxiety
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A vet-favorite daily calming supplement featuring L-theanine and botanical extracts for consistent anxiety management.
Nutramax Solliquin soft chews contain L-theanine (derived from green tea), magnolia officinalis bark extract, and Phellodendron amurense bark extract. These ingredients work together to promote relaxation and reduce stress without causing sedation. The 75-count bag provides over two months of daily use for most cats.
L-theanine is one of the most well-studied calming ingredients for pets, helping the body produce calming amino acids and dopamine to naturally manage stress levels. This makes Solliquin ideal for cats with chronic anxiety or behavioral issues.
What We Like
- Contains clinically studied L-theanine for anxiety relief
- 75-count bag offers a generous supply
- Won’t change your cat’s personality or cause drowsiness
What Could Be Better
- Chicken liver flavor doesn’t appeal to every cat
- Takes consistent daily use to see full benefits
Bottom Line: Solliquin is the top choice for cats who need ongoing daily calming support without sedation.
4. Rocco & Roxie Calming Treats – Best Tasting
- Unparalleled Support: Our delicious, chicken-flavored chews help keep your cat cool, calm, and relaxed; Every bite promotes a sense of relaxation and mental alertness to help maintain normal stress levels during thunderstorms, vacuuming, moving, vet visits, and other stressful situations
- Better Ingredients, Better Results: Our formula features premium calming ingredients like Sensoril Organic Ashwagandha and GABA, which help block stress signals in the brain to encourage relaxation and calmness; We’ve also included tryptophan, theanine, and the natural hormone melatonin, to enhance calming effects yet keep your cat alert
- Veterinarian Recommended: Our Calming health supplement is a vet-recommended, daily formula to help your cat feel relaxed, be calm, and maintain balanced behavior in stressful situations
- Delicious Multi-Textured Chews: With a crunchy outer layer and a soft, creamy center, our multi-textured chews are a one-of-a-kind delight that your cat will love; These tasty, chicken-flavored chews are made in the USA with no fillers, gums, or sweeteners—just pure, high-quality ingredients from around the world
- Buy With Confidence: You want the best for your best friend; We do, too; If you are not satisfied with the performance of this product, contact us; We are determined to make it right
Vet-recommended chews with organic ashwagandha and GABA in an irresistible crunchy-creamy format.
Rocco & Roxie calming treats combine organic ashwagandha, GABA, and melatonin in multi-textured chews with a crunchy exterior and soft, creamy center. These chicken-flavored chews are made in the USA with no fillers, gums, or artificial sweeteners. The formula is designed for daily use to help maintain balanced behavior during stressful situations.
The unique texture makes these treats highly palatable, and most cats eat them eagerly without any coaxing. Each bag provides a 30-day supply.
What We Like
- Organic ashwagandha and GABA for evidence-based calming
- Irresistible crunchy-and-creamy texture
- Made in the USA with no fillers or artificial ingredients
What Could Be Better
- Only a 30-day supply per bag
- Higher price point per serving
Bottom Line: If taste and ingredient quality are your priorities, Rocco & Roxie delivers premium calming support cats actually enjoy.
5. GNC Pets Advanced Calming Chews – Best for Occasional Stress
- GNC PETS ADVANCED CAT CALMING SUPPLEMENTS — GNC Pets Advanced Calming Soft Chews for Cats provide your cat with just the help needed to naturally relax
- 60 EASY TO SWALLOW CAT SOFT CHEWS —These 60 easy-to-swallow soft chews make it easy for your cat to stay calm. Use for separation, travel, or environmental stress as an effective way to relax
- NATURAL INGREDIENTS — This calming formula contains premium ingredients like thiamine, l-tryptophan, and chamomile for the perfect way to relax your furry friend.
- MADE IN THE USA — GNC Pets is proudly made in the US, providing you and your pet with safe, secure, and high quality products
- FEEDING DIRECTIONS — Give cats up to 10 lbs 1/2 a soft chew and cats 11 lbs and over 1 soft chew within a 12 hour period. Now both you and your feline friend can sit back and relax together
A trusted human wellness brand brings its expertise to feline calming with these gentle, effective soft chews.
GNC Pets Advanced Calming Chews feature a blend of thiamine, L-tryptophan, and chamomile designed for occasional use during separation, travel, or environmental stressors like thunderstorms and fireworks. The chicken-flavored chews are suitable for all cats over 6 months old. Each container includes 60 easy-to-swallow soft chews.
The familiar GNC name gives pet parents confidence in ingredient quality and manufacturing standards. This supplement is best for situational use rather than daily ongoing calming.
What We Like
- Backed by the trusted GNC brand reputation
- 60 chews per container at a competitive price
- Simple, proven calming ingredients
What Could Be Better
- Not formulated for chronic anxiety issues
- Some cats may not be interested in the flavor
Bottom Line: GNC Pets calming chews offer reliable occasional stress relief backed by a brand known for quality supplements.
6. Zesty Paws Calming Chews for Cats – Best Comprehensive Formula
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A multi-ingredient calming powerhouse that tackles stress from several angles with ashwagandha, L-theanine, and more.
Zesty Paws Calming Chews pack ashwagandha, organic chamomile, L-theanine, and L-tryptophan into every chew for a comprehensive approach to feline stress relief. The Suntheanine form of L-theanine used in this formula is clinically studied for its calming effects. These bacon-flavored soft chews come in a 60-count container.
This supplement works well for both daily use and situational stress, making it versatile enough for most cat anxiety scenarios.
What We Like
- Uses clinically studied Suntheanine L-theanine
- Multiple calming pathways in one supplement
- Versatile for both daily and situational use
What Could Be Better
- Bacon flavor is unusual for cat supplements
- Chews are slightly larger than some competing products
Bottom Line: Zesty Paws delivers one of the most comprehensive calming formulas available, addressing feline anxiety from multiple angles simultaneously.
7. Vetoquinol Zylkene – Best Natural Approach
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Derived from milk protein, Zylkene uses alpha-casozepine to naturally promote relaxation the way a nursing kitten calms down.
Vetoquinol Zylkene contains alpha-casozepine, a bioactive peptide derived from casein (a protein found in milk). This ingredient mimics the calming effect that nursing kittens experience, promoting a natural sense of relaxation without any sedative effects. The 75mg capsules are designed for small dogs and cats, and can be opened and mixed with food.
Zylkene is recommended for use during behavioral changes, new environments, travel, or any situation causing stress. Each box contains 30 capsules for a month’s supply.
What We Like
- Unique milk-protein-derived calming mechanism
- No sedative effects or behavioral changes
- Capsules can be opened and mixed with food
What Could Be Better
- Capsule format requires extra effort to administer
- May take 1-2 days before effects are noticeable
Bottom Line: Zylkene offers a uniquely natural calming approach that’s gentle, effective, and free from herbs or sedatives.
8. VetriScience Composure – Best Fast-Acting
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Starts working in 20-30 minutes with a formula that can be safely doubled or tripled for extra-stressful situations.
VetriScience Composure chews combine colostrum-derived bioactive proteins, L-theanine, and thiamine (vitamin B1) for rapid calming effects. The formula begins working within 20 to 30 minutes and lasts approximately 4 hours. The chicken liver-flavored chews come in bite-sized pieces that most cats accept readily.
One of the standout features is that the dosage can be safely increased (doubled or tripled) for particularly stressful events, giving you flexibility based on your cat’s needs.
What We Like
- Fast-acting formula works in 20-30 minutes
- Dosage can be safely adjusted for varying stress levels
- Colostrum provides additional immune support
What Could Be Better
- Effects last only about 4 hours
- Only 30 chews per container
Bottom Line: When you need quick calming relief for an upcoming vet visit or thunderstorm, Composure delivers results faster than most competitors.
9. Zesty Paws Calming Mousse – Best Alternative Format
- Yummy Mousse, Mellow Kitty! - Cat Calming Treats Cat Mousse is a delicious way to help calm and compose your kitty to keep them on their best behavior for car rides, thunderstorms, fireworks, and more.
- Features Suntheanine – This mousse cat supplement contains Suntheanine, a clinically studied form of L-Theanine that helps promote a sense of relaxation and calmness for your feline friend.
- Support for Stress & Hyperactivity - Ready for some relief? Help your hyper nervous pet relax and feel calmer during tough moments with the Ashwagandha and L-Tryptophan in this calming cat treats
- Calming for Cats - Includes Valerian Root and Vitamin B1 (Thiamine) to provide a relaxing feeling for cats during travel, storms, and being around other cats and dogs.
- Stressed? Calm Down Cat! - This cat calm mousse has a delicious chicken flavor that indoor and outdoor cats love, while also helping support their mood and behavioral health.
A lickable mousse format that’s perfect for cats who refuse chews and capsules but love a tasty treat.
Zesty Paws Calming Mousse contains Suntheanine L-theanine, ashwagandha, valerian root, L-tryptophan, and vitamin B1 in a delicious chicken-flavored mousse format. You can squeeze it onto a plate, apply it to your cat’s paw, or let them lick it directly from the tube. The 14-count pack of individual tubes makes dosing clean and convenient.
This innovative format is ideal for cats who absolutely refuse pills, chews, and powders. The creamy texture is highly appealing to most felines.
What We Like
- Unique mousse format cats find irresistible
- Includes valerian root for additional calming support
- Individual tubes are mess-free and easy to dose
What Could Be Better
- Only 14 tubes per pack limits the supply
- Higher cost per serving than chew-based options
Bottom Line: For the cat who refuses every supplement you’ve tried, this mousse format may be the solution you’ve been looking for.
How to Choose the Best Cat Calming Supplement
The first step in choosing a calming supplement is identifying your cat’s specific type of anxiety. Is it situational (vet visits, travel, storms) or ongoing (separation anxiety, multi-cat household stress, general nervousness)? Situational anxiety responds well to fast-acting supplements you give 30 minutes before the event, while chronic anxiety requires daily supplementation for consistent results.
Pay attention to the active ingredients and their evidence base. L-theanine, particularly the Suntheanine form, has strong clinical evidence for promoting calm behavior in cats. Alpha-casozepine (from milk protein) and colostrum-derived bioactive proteins are also well-studied options. Herbal ingredients like chamomile, valerian root, and ashwagandha have a long history of traditional use for anxiety relief.
Consider the delivery format carefully. Soft chews work well for treat-motivated cats, while picky eaters may do better with powders that blend into food or liquid mousse formats. Capsules that can be opened and sprinkled offer another option for finicky felines. The best supplement in the world won’t help if your cat refuses to take it.
Always check the recommended age and any contraindications. Most calming supplements are designed for adult cats, though some are safe for kittens over 12 weeks. If your cat is on any medications, consult your veterinarian before adding a calming supplement to ensure there are no interactions.
Benefits of Cat Calming Supplements
Calming supplements can dramatically improve quality of life for both stressed cats and their owners. Anxious cats often develop destructive behaviors like scratching furniture, spraying urine, excessive grooming, or hiding for extended periods. A good calming supplement helps reduce these stress-related behaviors by promoting a sense of security and relaxation.
Many calming supplements also offer secondary health benefits. Probiotics-based calming aids support digestive health alongside stress relief. Supplements containing B vitamins support nervous system function, while those with colostrum may provide immune system support. L-theanine promotes the production of calming neurotransmitters that benefit overall brain health.
For multi-cat households, calming supplements can help reduce inter-cat tension and conflicts. They’re also valuable tools for making transitions smoother, whether you’re moving to a new home, introducing a new pet, or dealing with changes in the household routine. When used consistently, calming supplements can help create a more peaceful environment for everyone.
Frequently Asked Questions
How quickly do cat calming supplements work?
It depends on the type. Fast-acting chews with L-theanine and colostrum can work within 20-30 minutes. Probiotic-based supplements like Purina Calming Care may take 4-6 weeks of daily use for full effects. Herbal supplements typically show results within a few days of consistent use.
Are calming supplements safe for kittens?
Most calming supplements are designed for adult cats, but some are safe for kittens over 12 weeks of age. Always check the product label for age recommendations and consult your veterinarian before giving any supplement to a kitten.
Can I give my cat calming supplements every day?
Many calming supplements are designed for daily use, including probiotic-based options and those containing L-theanine. However, some are intended for occasional situational use only. Check the product label for recommended frequency and consult your vet if you’re unsure.
Do calming supplements sedate my cat?
Quality calming supplements promote relaxation without sedation. Your cat should remain alert and able to function normally, just with reduced anxiety. If a supplement makes your cat lethargic or significantly drowsy, discontinue use and speak with your veterinarian.
Can I use calming supplements alongside pheromone diffusers?
Yes, calming supplements and pheromone diffusers work through different mechanisms and can be used together safely. Many veterinarians recommend this combination for cats with moderate to severe anxiety. The supplement works internally while the diffuser creates a calming environment.
What if my cat won’t eat the calming chews?
Try switching to a different format like a powder that blends into food, a liquid mousse, or capsules that can be opened and sprinkled. Some cats respond better to unflavored options mixed into their favorite wet food. If your cat refuses all oral supplements, pheromone diffusers or collars may be a better alternative.
Are there any side effects of cat calming supplements?
Side effects are rare with quality calming supplements. Some cats may experience mild digestive changes (soft stool or decreased appetite) when first starting a new supplement. These effects usually resolve quickly. Discontinue use and consult your vet if you notice any unusual behavior or persistent side effects.
Can calming supplements replace veterinary treatment for anxiety?
Calming supplements are best used as part of a comprehensive approach to feline anxiety. For mild to moderate stress, supplements may be sufficient on their own. However, cats with severe anxiety disorders may need prescription medication, behavioral modification therapy, or environmental changes in addition to supplementation. Always consult your veterinarian for a complete anxiety management plan.
