Best Prostate Supplements for Frequent Urination (2026) – Top 10 Reviewed
Frequent urination, especially at night, is one of the most disruptive symptoms of prostate enlargement. If you’re tired of constant bathroom trips interrupting your sleep and daily activities, you’ll find natural supplements specifically formulated to reduce urinary frequency, improve bladder control, and help you get through the night without multiple wake-ups.
Our Top Picks at a Glance
- Best Overall: Force Factor Prostate Ultimate – urologist-recommended for nighttime relief
- Best Value: Saw Palmetto PM with Melatonin – dual-action sleep and bladder support
- Best Premium: Snap Supplements Prostate Health – comprehensive urinary support
Quick Comparison
| Product | Key Ingredients | Form | Servings | Best For |
|---|---|---|---|---|
| Force Factor Prostate | Nettle, Saw Palmetto | Capsules | 60 | Nighttime urgency |
| Saw Palmetto PM | Saw Palmetto, Melatonin 3mg | Capsules | 60 | Sleep & bladder |
| Snap Supplements Prostate | Saw Palmetto, Beta-Sitosterol | Capsules | 90 | Overall frequency |
| Saw Palmetto Extract | Saw Palmetto, Beta-Sitosterol | Capsules | 60 | Urinary flow |
| Herbal Prostate Complex | Pygeum, Saw Palmetto | Capsules | 90 | Nighttime trips |
| Nighttime Defense | Saw Palmetto Extract | Capsules | 60 | Night protection |
| Saw Palmetto Night | Saw Palmetto, Sleep Blend | Capsules | 60 | Reduced urgency |
| Plant Sterols Complex | Beta-Sitosterol 500mg | Capsules | 90 | Bladder emptying |
| Saw Palmetto 640mg | Saw Palmetto, Pygeum, Zinc | Capsules | 60 | Complete support |
| Organic Pumpkin Seed Oil | Pumpkin Seed Oil | Softgels | 60 | Bladder control |
1. Force Factor Prostate Ultimate – Best Overall
- CONTAINS THE #1 UROLOGIST-RECOMMENDED INGREDIENT: Prostate Ultimate features patented USPlus, a premium lipidosterolic extract of saw palmetto. It’s the only USP-Verified saw palmetto extract, signifying the highest standards of purity and potency.
- IMPROVE URINARY DISCOMFORT BY UP TO 67%: In a clinical study on USPlus saw palmetto, a key ingredient in Prostate Ultimate, participants reported significant improvements in urinary discomfort from weak stream and straining.**
- INCREASE BLADDER EMPTYING & REDUCE NIGHTTIME BATHROOM TRIPS: This advanced prostate health supplement supports bladder control and comfort, helping reduce frequent nighttime interruptions so you can wake up feeling refreshed.
- CONTAINS POWERFUL PROSTATE HEALTH INGREDIENTS: Every dose contains a complete blend with USPlus, a premium USP-verified saw palmetto extract, beta-sitosterol, stinging nettle, pygeum, and more to support overall prostate health and urinary function.
- MADE IN THE USA & THIRD-PARTY TESTED: Force Factor Prostate Ultimate is made in America using globally sourced ingredients in GMP-compliant manufacturing facilities. All ingredients go through rigorous testing to validate their quality, potency, and purity.
The #1 urologist-recommended supplement specifically designed to reduce nighttime bathroom trips and improve urinary flow.
Force Factor Prostate Ultimate combines stinging nettle and saw palmetto in clinically studied doses to address frequent urination at its source. The nettle root extract is particularly effective for reducing nighttime urgency, while saw palmetto supports overall bladder and prostate health. Men report significantly fewer wake-ups and better sleep quality within weeks of starting this formula.
What We Like
- #1 urologist recommended for urinary frequency
- Specifically targets nighttime bathroom trips
- Fast-acting formula with noticeable results in 2-4 weeks
- Made in USA with pharmaceutical-grade ingredients
What Could Be Better
- Premium pricing reflects professional quality
- Requires consistent daily use for sustained benefits
Bottom Line: The top choice for men whose frequent urination is disrupting sleep and quality of life.
2. Saw Palmetto PM for Men with Melatonin 3mg – Best Value
- Sleep & Prostate Support - These Saw Palmetto PM capsules with melatonin and chamomile extract are designed to promote restful sleep while supporting prostate health and reducing nighttime bathroom trips.
- Easy Nightly Routine - As men age, prostate health becomes more important. We've made it easy for men to take one capsule at night to reduce symptoms of enlarged prostate and help reduce urination frequency at night.
- Saw Palmetto Extract - Our formula utilizes saw palmetto berries, known for their role in supporting hormone balance and prostate health, making it an essential addition to your nightly routine.
- Melatonin & Chamomile Combination - Featuring 3mg of melatonin and chamomile, these capsules support deeper, more restorative sleep, helping you wake up feeling refreshed and rejuvenated.
- Prostate Health Supplements for Men - Feel confident and regain your alpha male status with saw palmetto. Support your health and well-being with our daily vegan, non-GMO capsules.
A nighttime formula combining saw palmetto for bladder support with melatonin to help you sleep through reduced bathroom trips.
This innovative supplement addresses both sides of the nighttime urination problem: reducing the urge to go while helping you fall back asleep faster if you do wake up. The 3mg melatonin dose promotes healthy sleep cycles without morning grogginess, while saw palmetto supports prostate and bladder function. It’s designed specifically for evening use.
What We Like
- Dual-action formula for sleep and bladder support
- 3mg melatonin helps with sleep quality
- Designed specifically for nighttime use
- Excellent value for comprehensive nighttime support
What Could Be Better
- Contains melatonin which may not suit everyone
- Primarily addresses nighttime rather than daytime frequency
Bottom Line: An excellent value formula that tackles both frequent nighttime urination and sleep quality.
3. Snap Supplements Prostate Health – Best Premium
- Supports Healthy Prostate & Urinary Function: Our prostate health supplement for men is formulated with saw palmetto, stinging nettle root extract, and beta-sitosterol to help maintain healthy prostate function, promote urinary comfort, and support bladder tone for fewer nighttime bathroom trips.*
- Turmeric For Inflammatory Balance: Our prostate support supplement features turmeric extract standardized to 95% curcuminoids, along with magnesium. Together, these ingredients support a healthy inflammatory response and overall cellular wellness.*
- Prostate Health Mushroom Blend: Combines maitake and reishi mushrooms with supportive botanicals and nutrients to deliver antioxidant cellular protection. Helps maintain healthy immune function and supports the body’s natural detoxification pathways while promoting overall prostate wellness.*
- DHT Blocker for Men: Features plant-based ingredients traditionally used to support men’s overall wellness and promote healthy hair and scalp. Designed for those seeking natural, botanical support, this formula pairs easily with daily vitamins for men and is convenient to take with food at home or on the go.*
- Quality You Can Trust: Our vitamins and supplements are crafted by health experts and manufactured in the USA with globally sourced ingredients. This supplement is non-GMO, free of major allergens, gluten-free, vegan, and manufactured in a GMP-certified facility to ensure purity, potency, and quality.
A doctor-formulated premium blend that reduces urinary frequency both day and night through multiple complementary mechanisms.
This comprehensive supplement combines saw palmetto with beta-sitosterol and supporting herbs to address all aspects of frequent urination. The formula works by supporting healthy prostate size, improving bladder control, and reducing the urgency that drives constant bathroom trips. The 90-capsule supply and vegetarian formula make it suitable for long-term daily use.
What We Like
- Doctor-formulated for maximum effectiveness
- Reduces both daytime and nighttime frequency
- 90-capsule bottle provides excellent value
- Improves overall bladder control and emptying
What Could Be Better
- Results build gradually over several weeks
- Complex formula may not appeal to minimalists
Bottom Line: A premium comprehensive formula for those seeking professional-grade urinary frequency relief.
4. Saw Palmetto for Men with Beta-Sitosterol
- Advanced Prostate Health Formula - We are proud to be a leading name in saw palmetto supplements because we believe prostate supplements for men should feature some of nature’s finest ingredients
- Hair Vitamins for Men - Hair health can be a tricky subject for guys so why not try an herbal DHT blocker for men packed with zinc and selenium hair vitamins for men that may help promote overall health
- Men's Wellness Staple - Harness the power of nourishing saw palmetto berries packed with naturally occurring hair vitamins for thicker and healthier looking hair with our supplement for men
- Trusted Quality - Put your trust in our saw palmetto and beta sitosterol for prostate health with vitamins for hair health because we rigorously test all of our products because you deserve the best
- Natures Craft Cares - We understand the struggle of the aging male so we developed these hair health pills & hair vitamins for improved hair health with guys like you in mind with premium ingredients
A focused two-ingredient formula that improves urinary flow and reduces frequency through clinically proven compounds.
This supplement delivers therapeutic doses of saw palmetto and beta-sitosterol, the two most researched ingredients for urinary symptoms. By improving bladder emptying and reducing residual urine volume, it helps decrease the frequency of bathroom trips. The standardized extracts ensure consistent potency for reliable results.
What We Like
- Two most clinically proven ingredients
- Improves bladder emptying to reduce frequency
- Standardized extracts for reliable results
- Simple formula without unnecessary additives
What Could Be Better
- Lacks herbs specifically for nighttime symptoms
- May take 6-8 weeks for full effect
Bottom Line: A straightforward, evidence-based supplement for reducing urinary frequency naturally.
5. Herbal Prostate Supplement with Pygeum
- Vitamin Mineral and Herbal Prostate Formula - We believe any effective prostate supplement should feature a variety of beneficial ingredients including zinc and beta sitosterol for prostate health
- Better Bladder Support - Our prostate supplements for men are packed with extra strength Plant sterols Saw palmetto Pygeum and Pumpkin seed extract for bladder control and urinary tract health
- Fewer Bathroom Trips - Minimize your pit stops with our advanced complex with saw palmetto berries and beta-sitosterol to help decrease pressure on the prostate better flow and increased emptying
- Men's Health Vitamin - We combined some of the finest herbs and minerals to support your prostate including Copper Vitamin E Stinging nettle Graviola Cat's claw Quercetin Uva ursi and so much more
- Natures Craft Quality - We're proud to be a leading name in men's health supplements because we believe you deserve the finest quality lab tested proven ingredients to start feeling your best
A potent herbal blend emphasizing pygeum africanum, which is specifically effective for reducing nighttime urination.
Pygeum has extensive clinical research showing it significantly reduces nocturia (nighttime urination) more effectively than some other herbs. This formula combines pygeum with saw palmetto and beta-sitosterol to provide comprehensive support for frequent urination. Men particularly troubled by nighttime trips often see the most dramatic improvement with pygeum-based formulas.
What We Like
- Pygeum specifically targets nighttime frequency
- Clinical research supporting nocturia reduction
- Includes graminex flower pollen for added support
- 90-capsule supply for extended use
What Could Be Better
- Pygeum may cause mild stomach upset initially
- Benefits build gradually over 4-8 weeks
Bottom Line: An excellent choice for men whose nighttime urination is their primary concern.
6. Nighttime Defense Saw Palmetto for Men
- Advanced Prostate Formula - We are proud to be a leading name in saw palmetto herbal supplements because we believe prostate supplements for men should feature some of nature’s finest ingredients
- Hair Vitamins for Men - Hair health can be a tricky subject for guys so why not try an herbal DHT blocker for men packed with zinc and selenium hair vitamins for men that may help promote health
- Saw Palmetto Supplement - Harness the power of nourishing saw palmetto berries packed with naturally occurring hair vitamins for thicker looking hair with our enhanced hair supplement for men
- Trusted Quality - Put your trust in our saw palmetto and beta sitosterol for prostate health with vitamins for hair because we rigorously test all of our products because you deserve the best
- Natures Craft Cares - We understand the struggle of the aging male so we developed these hair pills and hair vitamins for faster hair with guys like you in mind with premium ingredients
A specialized evening formula designed specifically to reduce nighttime bathroom trips and urgency.
This supplement is formulated for evening dosing to provide maximum support during the night when frequent urination is most disruptive. The saw palmetto extract works throughout the night to reduce urgency and help maintain bladder control. Many users report being able to sleep through the night without interruption after consistent use.
What We Like
- Specifically designed for nighttime use
- Helps reduce urgent wake-ups to urinate
- Supports better sleep quality
- Easy bedtime dosing schedule
What Could Be Better
- Focuses primarily on nighttime symptoms
- May need additional daytime support
Bottom Line: A targeted nighttime formula for those primarily troubled by sleep disruption from frequent urination.
7. Saw Palmetto for Men – Nighttime Formula
- Prostate Health Supplement for Men - Say hello to saw palmetto prostate support specifically designed to minimize frequent nighttime trips to the bathroom and support better bladder control for men
- Unique Prostate Formula - Unlike many other mens prostate health supplements our saw palmetto capsules contain lycopene pumpkin seed extract for bladder control and 3mg melatonin to help you sleep
- Men’s Health Must Have - Rest assured with our overactive bladder control pills with saw palmetto berries to promote urinary tract health and decrease pressure on the prostate for increased emptying
- Promote Hair Health - We combined saw palmetto powder and pumpkin seed oil for hair health for men to assist faster and stronger looking hair while you sleep thanks to its potent nutrient contents
- Natures Craft Quality - We're proud to be a leading name in saw palmetto herbal supplements because we believe you deserve the best quality lab tested effective ingredients to start feeling your best
An evening-optimized supplement combining saw palmetto with complementary herbs to reduce nighttime urgency.
This formula recognizes that nighttime urinary frequency requires a specialized approach. By combining saw palmetto with herbs that support relaxation and bladder control, it helps reduce both the frequency and urgency of nighttime bathroom trips. The gentle formula won’t interfere with sleep but helps you stay asleep longer between bathroom visits.
What We Like
- Optimized for evening dosing
- Reduces both frequency and urgency
- Gentle formula that supports sleep
- Helps extend time between bathroom trips
What Could Be Better
- Evening-specific formula limits flexibility
- Some users prefer 24-hour coverage
Bottom Line: A well-designed evening supplement for those whose urinary frequency peaks at night.
8. Plant Sterols Complex with Beta-Sitosterol
- Prostate supplement for men - Beta sitosterol for prostate health is one of the essential plant sterols for men’s health that may help reduce nighttime trips to the bathroom and trouble emptying
- Try our beta sitosterol supplement today featuring phytosterols including campesterol stigmasterol brassicasterol and sitostanol for better internal balance
- Fewer sleep interruptions - Support your bladder health and better bladder control to reduce all those nightly trips to the bathroom and frequent urination so you can relax and rest better and longer
- Immune support - Reap the benefits of enhanced immune system support with our daily vitamins for men formula powered by phytosterols packed with immune support vitamins for full body wellness
- Premium quality - Natures Craft products use cruelty free non GMO potent ingredients and are formulated in American GMP facilities because you deserve high quality guilt and worry-free supplements
A high-potency beta-sitosterol formula that improves bladder emptying to naturally reduce urination frequency.
Beta-sitosterol works by helping the bladder empty more completely, which means you don’t need to return as frequently. This 500mg dose provides therapeutic levels shown in clinical studies to reduce urinary frequency and improve flow. The three-month supply makes it economical for consistent long-term use necessary to maintain benefits.
What We Like
- High 500mg therapeutic dose
- Improves bladder emptying efficiency
- Clinical research backing effectiveness
- 90-capsule bottle lasts three months
What Could Be Better
- Single compound may work best with other ingredients
- Gradual effect requires patience
Bottom Line: An effective focused supplement using the most clinically proven ingredient for urinary frequency.
9. Saw Palmetto 640mg with Pumpkin Seed and Pygeum
- Saw Palmetto for Men — Discover the power of Saw Palmetto, specially crafted for men’s wellness. Extra strength supplement delivering double the clinically tested dose for powerful prostate and DHT-blocking support. Derived from premium saw palmetto seeds with 45% fatty acids, the key active ingredient for optimal men's health.
- Prostate Support Complex — Saw Palmetto is a traditional men’s herb, a time-honored remedy renowned for supporting comprehensive prostate health. Infused with Pumpkin Seed, Zinc, Stinging Nettle, and Pygeum, this blend supports Saw Palmetto's effectiveness while addressing multiple aspects of men’s well-being.
- Prostate, Hair & Urinary Support — Saw Palmetto supports healthy prostate function with natural DHT-blocking properties, potentially helping to reduce hair loss & enhance hair strength. Aids urinary tract health by encouraging fewer urinations & helping with a more natural, comfortable flow.
- Made in USA With Globally Sourced Ingredients — Our Saw Palmetto supplement is proudly manufactured in the USA under strict quality control standards. Non-GMO, DYE-free, No Gluten & Soy-Free, and GMP-certified, prostate supplements for men are produced with the most potent ingredients for maximum efficacy & purity in every batch.
- Trustworthy Service — At NUTRAHARMONY, we are committed to providing only premium-quality supplements, including our carefully crafted prostate health supplements for men. Our exceptional customer service ensures that your satisfaction is our top priority, making your wellness journey as seamless and trustworthy as possible.
A comprehensive multi-herb formula that addresses frequent urination through five complementary mechanisms.
This supplement combines saw palmetto’s DHT-blocking properties with pygeum’s specific benefits for nighttime urination, pumpkin seed’s bladder support, nettle’s flow improvement, and zinc’s prostate health support. The multi-pathway approach often provides more complete relief than single-ingredient formulas, addressing both the urgency and frequency components of the problem.
What We Like
- Five proven ingredients work synergistically
- High 640mg saw palmetto dose
- Addresses both day and night symptoms
- Comprehensive approach to urinary frequency
What Could Be Better
- Multiple ingredients increase complexity
- Higher capsule count per serving
Bottom Line: An excellent all-in-one formula for comprehensive urinary frequency management.
10. Organic Pumpkin Seed Oil
- Organic Cold-Pressed Pumpkin Seed Oil - Our pumpkin seed oil is cold-pressed, preserving its rich vitamins, unsaturated fatty acids, and carotenoids to help support hormone balance and overall health.
- Hair and Skin Health Support - Packed with essential nutrients, pumpkin seed oil may help support hair and skin health, contributing to their vitality and appearance, making it an ideal supplement for beauty care.
- Prostate and Urinary Health for Men - Pumpkin seed oil may promote healthy prostate function and bladder control, supporting normal urinary function and maintaining a healthy prostate size.
- Versatile, Easy-to-Use Liquid Drops - This liquid pumpkin oil provides an easy and convenient way to incorporate beneficial nutrients into your daily routine—use it directly, mix with smoothies, or add to recipes like dressings.
- Suggested Use - Shake gently before use. The product is derived from pressed seeds, providing an oil. Since oil and water do not mix well, we recommend taking the drops directly by mouth, a smoothie, or incorporating in a recipe, like a dressing. If you choose to mix in water, please stir occasionally so the product mixes before consumption.
USDA organic pumpkin seed oil that naturally supports bladder control and reduces urinary frequency.
Pumpkin seed oil has traditional use and modern research supporting its effectiveness for overactive bladder and frequent urination. The cold-pressed organic formula preserves beneficial compounds including plant sterols and essential fatty acids. Studies show pumpkin seed oil can reduce nighttime urination and improve overall bladder control with consistent use.
What We Like
- USDA certified organic and pure
- Research-backed for bladder control
- Reduces nighttime urination naturally
- Gentle approach with minimal side effects
What Could Be Better
- Effects may be milder than concentrated extracts
- Works best as part of comprehensive approach
Bottom Line: A natural, gentle option for those preferring organic single-ingredient supplements for bladder support.
How to Choose the Best Supplement for Frequent Urination
When selecting a supplement to reduce urinary frequency, identify whether your primary concern is daytime trips, nighttime urgency, or both. Nighttime frequency (nocturia) often responds particularly well to pygeum africanum and specialized evening formulas that may include sleep support. Daytime frequency typically benefits from saw palmetto and beta-sitosterol that improve overall bladder control and prostate health throughout the day.
Look for supplements containing clinically effective doses of proven ingredients. Saw palmetto should be present at 320mg of standardized extract, beta-sitosterol at 60-130mg, and pygeum at 100-200mg for optimal results. Products using proprietary blends that don’t disclose individual amounts may contain insufficient quantities to provide meaningful symptom relief.
Consider whether you want immediate symptom management or long-term prostate health support. Some ingredients like pygeum may begin reducing nighttime trips within 2-4 weeks, while saw palmetto’s full effects on prostate size and overall frequency may take 8-12 weeks to develop. Multi-ingredient formulas often provide both faster initial relief and sustained long-term benefits.
Pay attention to quality markers including third-party testing, standardized extracts, and GMP certification. These ensure you’re getting consistent potency and purity without contaminants. For frequent urination supplements, extraction methods matter significantly—look for products specifying liposterolic extract of saw palmetto or standardized pygeum bark extract for best absorption and effectiveness.
Finally, understand that supplements work best as part of a comprehensive approach. Timing fluid intake (limiting evening beverages), avoiding bladder irritants like caffeine and alcohol, and doing pelvic floor exercises can enhance supplement effectiveness. Choose a high-quality product you can take consistently, as sporadic use won’t provide the sustained relief necessary to improve quality of life.
Benefits of Supplements for Frequent Urination
The most immediate benefit of effective urinary frequency supplements is improved sleep quality. Many men report reducing nighttime bathroom trips from 3-4 times per night to just once or not at all within 4-6 weeks of consistent use. This uninterrupted sleep translates to better energy, mood, and cognitive function during the day, dramatically improving overall quality of life.
Supplements that reduce urinary frequency also improve bladder control and reduce urgency—the sudden, overwhelming need to urinate. This means fewer anxious moments searching for bathrooms during meetings, car trips, or social events. Many men report feeling more confident and less controlled by their bladder as their symptoms improve with supplementation.
By supporting healthy prostate size and function, these supplements address the root cause of frequent urination rather than just masking symptoms. Ingredients like beta-sitosterol and saw palmetto can help slow or prevent further prostate enlargement, potentially reducing the need for more aggressive interventions down the road. This preventive aspect makes early supplementation particularly valuable.
Natural supplements offer symptom relief without the side effects common with prescription medications for frequent urination. Alpha-blockers can cause dizziness and fatigue, while anticholinergics may cause dry mouth and constipation. Herbal approaches typically have minimal side effects while still providing clinically meaningful improvements in urinary frequency and quality of life for men with mild to moderate symptoms.
Frequently Asked Questions
What causes frequent urination in men?
The most common cause of frequent urination in men over 50 is benign prostatic hyperplasia (BPH), where the enlarged prostate compresses the urethra and prevents complete bladder emptying. This leaves residual urine that triggers frequent urges. Other causes include overactive bladder, urinary tract infections, diabetes, and excessive fluid intake. Consult a healthcare provider to rule out serious conditions before starting supplements.
How quickly will supplements reduce my bathroom trips?
Most men notice some improvement in urinary frequency within 2-4 weeks, with maximum benefits appearing at 8-12 weeks of consistent daily use. Pygeum-based formulas may show faster results for nighttime trips, while saw palmetto’s effects build more gradually. Keep a bathroom diary to track objective progress, as improvements can be subtle at first.
Can I take these supplements with prescription BPH medications?
Many supplements can be safely combined with prescription BPH medications, but you should always consult your healthcare provider first. Some combinations may be synergistic, allowing dose reduction of pharmaceuticals over time. Never adjust or stop prescription medications without medical supervision, even if supplements are helping your symptoms.
Will these supplements work for nighttime urination specifically?
Yes, certain supplements are particularly effective for nocturia (nighttime urination). Pygeum africanum has strong clinical evidence for reducing nighttime bathroom trips specifically. Saw Palmetto PM formulas that combine prostate support with melatonin address both the urge and sleep quality. Most men report nighttime frequency as their most improved symptom with consistent supplementation.
Are there lifestyle changes that help supplements work better?
Yes, several lifestyle modifications enhance supplement effectiveness: limit fluid intake 2-3 hours before bed, reduce caffeine and alcohol (both bladder irritants), practice double voiding (urinate, wait a moment, try again), do pelvic floor exercises, and maintain a healthy weight. These habits combined with quality supplements often provide better results than supplements alone.
What’s the difference between urgency and frequency?
Frequency refers to how often you need to urinate (more than 8 times in 24 hours is considered frequent). Urgency is the sudden, compelling need to urinate immediately. Both often occur together with BPH. Beta-sitosterol tends to help more with frequency by improving bladder emptying, while pygeum particularly addresses urgency and nighttime symptoms.
Can supplements completely eliminate frequent urination?
For mild to moderate symptoms, supplements may reduce frequency to normal or near-normal levels. However, they rarely eliminate symptoms completely in more advanced cases. Most men experience 30-50% reduction in urinary frequency and improved flow, which significantly improves quality of life even if some symptoms persist. Severe symptoms may require medical intervention beyond supplements.
Should I take supplements in the morning or evening?
Standard prostate formulas can be taken anytime, though many men prefer morning to ensure consistent daily use. Specialized nighttime formulas containing melatonin or designed for evening use should be taken 30-60 minutes before bed. If taking multiple daily doses, spacing them evenly (morning and evening) often provides the most consistent symptom control throughout the day and night.
