9 Best MSM Supplements for Dogs (2026) Reviewed
Methylsulfonylmethane (MSM) is a naturally occurring sulfur compound that has become a popular choice among pet owners looking to support their dog’s joint health, reduce inflammation, and improve overall mobility. MSM provides organic sulfur, which is critical for the formation of collagen, glucosamine, and connective tissue—all essential components of healthy joints.
If you’ve noticed your dog slowing down on walks, struggling to climb stairs, or showing stiffness after rest, an MSM supplement might help support their comfort and mobility. While some dogs benefit from pure MSM powders, others do better with combination formulas that include glucosamine, chondroitin, and other joint-supporting ingredients.
We researched dozens of MSM supplements on Amazon, examining ingredient quality, MSM concentration, palatability reviews, brand reputation, and certifications like NASC Quality Seal and GMP manufacturing. Below you’ll find our top picks for 2026, suitable for dogs of all sizes and life stages.

Table of Contents
- Quick Comparison Table
- Best MSM Supplements by Dog Size
- 1. Nutramax Dasuquin with MSM — Best Overall
- 2. Nutramax Cosequin Maximum Strength Plus MSM — Best Vet-Recommended
- 3. Zesty Paws Mobility Bites with MSM — Best Soft Chews
- 4. NaturVet MSM Chewable Tablets — Best Pure MSM Tablets
- 5. TopDog Health MSM Joint Boost Powder — Best Pure MSM Powder
- 6. KALA HEALTH PeakTails MSM Powder — Best Value Powder
- 7. VetIQ Hip & Joint Supplement — Best Budget Option
- 8. Amazon Basics Hip & Joint — Best for Basic Support
- 9. Wuffes Advanced Hip & Joint — Best for Small Breeds
- MSM Dosing Guide for Dogs
- What to Look for in an MSM Supplement
- Signs Your Dog May Need MSM
- Safety Considerations
- Frequently Asked Questions
- Final Verdict
Quick Comparison Table
| Product | Form | MSM Per Serving | Pet Size | Count | Key Feature | Best For |
|---|---|---|---|---|---|---|
| Nutramax Dasuquin with MSM | Chewable Tablets | 800 mg | Large Dogs (60+ lbs) | 150 | ASU + Boswellia Formula | Overall Best |
| Nutramax Cosequin Plus MSM | Chewable Tablets | 250 mg | All Sizes | 250 | #1 Vet Recommended | Vet-Recommended |
| Zesty Paws Mobility Bites | Soft Chews | 250 mg OptiMSM | All Sizes | 250 | OptiMSM + Great Taste | Picky Eaters |
| NaturVet MSM Tablets | Chewable Tablets | 1,000 mg | All Sizes | 250 | Pure MSM Only | Pure MSM Support |
| TopDog Health MSM Powder | Powder | Customizable | All Sizes | 1 lb | 99.9% Pure OptiMSM | Large/Giant Breeds |
| KALA HEALTH PeakTails MSM | Powder | Customizable | All Sizes | 1 lb | OptiMSM Certified | Value Seekers |
| VetIQ Hip & Joint | Soft Chews | 210 mg | All Sizes | 180 | NASC Certified + Krill | Budget-Conscious |
| Amazon Basics Hip & Joint | Soft Chews | 400 mg | All Sizes | 120 | Green-Lipped Mussel | Basic Support |
| Wuffes Hip & Joint | Soft Chews | 200 mg | Small/Medium | 60 | Small Breed Formula | Small Dogs |
Best MSM Supplements by Dog Size
Best for Small Dogs (Under 25 lbs): Wuffes Advanced Hip & Joint for Small/Medium Breeds — specifically formulated with appropriate dosages for smaller dogs, gentle on sensitive stomachs.
Best for Medium Dogs (25-60 lbs): Zesty Paws Mobility Bites — easy-to-dose soft chews with premium OptiMSM that works well for mid-sized breeds.
Best for Large Dogs (60+ lbs): Nutramax Dasuquin with MSM for Large Dogs — the veterinarian-recommended formula with 800 mg MSM per tablet specifically dosed for larger breeds.
Best for Senior Dogs: Nutramax Cosequin Maximum Strength Plus MSM — gentle yet effective formula trusted by veterinarians for aging dogs with joint concerns.
Best for Picky Eaters: Zesty Paws Mobility Bites — duck-flavored soft chews with high palatability ratings from finicky dogs.
1. Nutramax Dasuquin with MSM for Large Dogs — Best Overall
Nutramax Dasuquin with MSM is our top pick for dogs needing comprehensive joint support, combining 800 mg of MSM with glucosamine, chondroitin, ASU (avocado/soybean unsaponifiables), Boswellia serrata extract, and green tea extract in the #1 veterinarian-recommended joint health brand.
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Dasuquin goes beyond standard glucosamine supplements by incorporating ASU, a patented ingredient shown to work synergistically with glucosamine and chondroitin to stimulate cartilage production. The addition of 800 mg MSM per tablet provides sulfur support for connective tissue, while Boswellia serrata adds natural anti-inflammatory properties.
The formula is backed by extensive research from Nutramax Laboratories, a company with over 25 years in veterinary supplements. Each batch undergoes rigorous quality testing that exceeds industry standards, and the product is manufactured in the USA with globally sourced ingredients.
Key Specifications:
- Form: Chewable Tablets
- Active Ingredients: Glucosamine HCl (900 mg), MSM (800 mg), Chondroitin Sulfate (350 mg), ASU (90 mg), Boswellia Serrata (40 mg), Green Tea Extract (32 mg)
- Pet Size: Large Dogs (60-120 lbs)
- Count: 150 tablets
- Daily Serving: Initial 4-6 weeks: 2 tablets; Maintenance: 1 tablet
- Flavor: Natural chicken flavor
- Quality Certifications: Made in USA, Nutramax Quality Standards
Palatability Note: Most dogs readily accept the chicken-flavored tablets, though some owners report crushing them into food for fussier eaters.
Considerations: This formula is specifically designed for large dogs over 60 lbs. Small and medium dogs should use the Dasuquin for Small/Medium Dogs formula (available here) with adjusted ingredient amounts.
2. Nutramax Cosequin Maximum Strength Plus MSM — Best Vet-Recommended
Cosequin Maximum Strength Plus MSM is the #1 veterinarian-recommended retail joint supplement brand, offering a proven combination of glucosamine, chondroitin, and MSM in tasty chewable tablets suitable for dogs of all sizes.
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Cosequin has been a trusted name in joint supplements since 1992, with its specific glucosamine hydrochloride (FCHG49) and chondroitin sulfate (TRH122) formulations shown to be safe, effective, and bioavailable in peer-reviewed, published veterinary studies. The addition of MSM provides supplemental sulfur to support cartilage and connective tissue maintenance.
The formula is versatile enough for both young active dogs needing preventive support and senior dogs experiencing age-related joint stiffness. Available in multiple count sizes (60, 132, 180, and 250 tablets), it offers flexibility for different household needs.
Key Specifications:
- Form: Chewable Tablets
- Active Ingredients: Glucosamine HCl (600 mg), Chondroitin Sulfate (300 mg), MSM (250 mg), Manganese (3 mg)
- Pet Size: All sizes (dosing varies by weight)
- Count: 250 tablets
- Daily Serving: Under 10 lbs: ½ tablet; 10-24 lbs: 1 tablet; 25-49 lbs: 2 tablets; 50-100 lbs: 3 tablets; Over 100 lbs: 4 tablets
- Flavor: Chicken
- Quality Certifications: Made in USA, #1 Vet Recommended
Palatability Note: The chicken flavor is well-accepted by most dogs. Some owners report giving it as a treat, while others mix it into food.
Considerations: For dogs with more advanced joint concerns, the upgraded Dasuquin formula may provide additional benefits due to its ASU and Boswellia content.
Nutramax Cosequin for Dogs Joint Health Supplement, Contains Glucosamine for Dogs, Plus Chondroitin, Supports Healthy Joints, Chewable Tablets, 250 Count
3. Zesty Paws Mobility Bites with MSM — Best Soft Chews
Zesty Paws Mobility Bites deliver premium OptiMSM (500 mg per 2 chews) alongside glucosamine, chondroitin, and vitamins C and E in highly palatable duck-flavored soft chews that dogs actually enjoy eating.
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What sets Zesty Paws apart is their use of OptiMSM, a premium form of MSM that undergoes a four-stage distillation process ensuring 99.9% purity. This purification process removes impurities while maintaining the sulfur compound’s effectiveness for muscle and joint support.
Zesty Paws is an NASC (National Animal Supplement Council) member, meaning they’ve passed stringent independent quality audits. The soft chew format makes daily administration easy, and the duck flavor consistently receives high marks for palatability from pet owners.
Key Specifications:
- Form: Soft Chews
- Active Ingredients: Glucosamine HCl (300 mg), OptiMSM (250 mg), Chondroitin Sulfate (50 mg), Vitamin C, Vitamin E
- Pet Size: All sizes
- Count: 250 soft chews
- Daily Serving: Up to 25 lbs: 1 chew; 26-75 lbs: 2 chews; Over 75 lbs: 3 chews
- Flavor: Duck
- Quality Certifications: NASC Quality Seal, Made in USA
Palatability Note: Excellent acceptance rate—most dogs treat these as a reward rather than a supplement.
Considerations: The glucosamine and chondroitin amounts are lower than some veterinary-grade formulas, so dogs with significant joint issues may benefit from higher-strength options.
Zesty Paws Hip and Joint for Dogs, Glucosamine for Dogs Hip and Joint Supplement with Chondroitin, MSM, Vitamins C & E - Duck, 250 Count
4. NaturVet MSM Chewable Tablets — Best Pure MSM Tablets
NaturVet MSM Chewable Tablets provide 1,000 mg of pure methylsulfonylmethane per tablet, making them ideal for pet owners who want to add MSM to an existing joint supplement regimen or prefer a standalone MSM product.
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Sometimes you want just MSM without additional ingredients—perhaps you’re already giving your dog glucosamine and chondroitin separately, or you want to customize your dog’s joint support protocol. NaturVet’s pure MSM tablets fill that niche perfectly.
NaturVet has been manufacturing pet supplements since 1994 and maintains cGMP-compliant facilities. Their MSM tablets are veterinarian-formulated and suitable for dogs over 12 weeks of age. At 1,000 mg per tablet, they offer one of the highest MSM concentrations in a chewable format.
Key Specifications:
- Form: Chewable Tablets
- Active Ingredients: Methylsulfonylmethane (MSM) (1,000 mg)
- Pet Size: All sizes (dogs over 12 weeks)
- Count: 250 tablets
- Daily Serving: Up to 15 lbs: ½ tablet; 15-30 lbs: 1 tablet; 30-60 lbs: 2 tablets; Over 60 lbs: 3 tablets
- Flavor: Natural flavoring
- Quality Certifications: Veterinarian Formulated, cGMP Facility, Made in USA
Palatability Note: Mixed reviews—some dogs accept them readily while others require hiding in food or treats. The tablets are firm and may need crushing for some dogs.
Considerations: As a pure MSM product, this doesn’t include glucosamine or chondroitin. Consider pairing with a complete joint supplement for comprehensive support.
NaturVet Methylsulfonylmethane Joint Support Dog Supplement Helps Support Healthy Cartilage, Tissue and Joints in Dogs Includes MSM, Sulfur-Rich Compounds 250 Ct.
5. TopDog Health MSM Joint Boost Powder — Best Pure MSM Powder
TopDog Health MSM Joint Boost offers 99.9% pure OptiMSM in powder form, providing maximum dosing flexibility for large and giant breed dogs who need higher amounts of MSM than standard chews provide.
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Powder supplements offer significant advantages for owners of large breed dogs: you can customize the dose precisely, it’s more economical per milligram than chews or tablets, and it mixes easily into wet food or sprinkled over kibble.
TopDog Health uses OptiMSM, the only MSM manufactured in the USA and the only licensed form approved for animal use. Their quadruple distillation process ensures pharmaceutical-grade purity. The unflavored powder works well for dogs who might be sensitive to artificial flavoring.
Key Specifications:
- Form: Powder
- Active Ingredients: OptiMSM 99.9% Pure
- Pet Size: All sizes (especially suited for large/giant breeds)
- Count: 1 lb (approximately 454 servings at 1,000 mg)
- Daily Serving: Typically 50-100 mg per 10 lbs body weight (consult vet for specific dosing)
- Flavor: Unflavored
- Quality Certifications: OptiMSM Certified, Made in USA, GMP Facility
Palatability Note: MSM powder has a slightly bitter taste. Most dogs accept it mixed into wet food; some owners add a small amount of low-sodium broth to improve acceptance.
Considerations: Requires measuring and mixing. Not as convenient as pre-dosed chews, but offers better value for multi-dog households or large breeds.
TopDog Health - MSM Joint Boost Powder - Hip & Joint Dog Supplement for Joint Mobility & Flexibility - Natural Anti-Inflammatory with Sulfur - Unflavored
6. KALA HEALTH PeakTails MSM Powder — Best Value Powder
KALA HEALTH PeakTails offers 99.9% pure OptiMSM in a 1 lb container at a competitive price point, making it an excellent value for pet owners who want premium-quality MSM powder without premium pricing.
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PeakTails uses the same OptiMSM found in higher-priced supplements—a US-sourced, quadruple-distilled form of methylsulfonylmethane that meets strict purity standards. The difference is in the no-frills packaging and direct-to-consumer model that keeps costs down.
In addition to joint mobility support, MSM has been shown to support healthy skin and a shiny coat due to its sulfur content, which is a key building block of keratin. This makes PeakTails a good choice for dogs with both joint and coat concerns.
Key Specifications:
- Form: Powder
- Active Ingredients: OptiMSM 99.9% Pure
- Pet Size: All sizes
- Count: 1 lb
- Daily Serving: Varies by weight; start with 50 mg per 10 lbs body weight
- Flavor: Unflavored (also available in natural chicken flavor)
- Quality Certifications: OptiMSM Certified, US-Sourced
Palatability Note: The chicken-flavored version receives better palatability reviews than unflavored. Both mix well into wet food.
Considerations: Pure MSM only—no glucosamine or chondroitin. Best used as an add-on to a complete joint supplement or existing regimen.
KALA HEALTH PeakTails MSM Powder for Dogs 1 lb, Pure Organic Sulfur, Supports Joint Health, Mobility & Comfort US-Sourced MSM, Flavorless Powder
7. VetIQ Hip & Joint Supplement — Best Budget Option
VetIQ Maximum Strength Hip & Joint delivers glucosamine, MSM, and krill in NASC-certified soft chews at a price point that makes daily joint support accessible for budget-conscious pet owners.
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Don’t let the lower price fool you—VetIQ maintains NASC certification and veterinarian recommendation status. The formula includes krill as an omega-3 source, which provides additional anti-inflammatory benefits alongside the traditional glucosamine and MSM combination.
The 180-count container provides excellent value, especially for multi-dog households. VetIQ products are cold-formed to preserve the integrity of active ingredients, ensuring you get the full benefit of each chew.
Key Specifications:
- Form: Soft Chews
- Active Ingredients: Glucosamine HCl (600 mg), MSM (210 mg), Krill, Omega-3 Fatty Acids, Hyaluronic Acid
- Pet Size: All sizes (minimum 5 lbs)
- Count: 180 soft chews
- Daily Serving: 5-15 lbs: 1 chew every other day; 16-30 lbs: 1 chew; 31-60 lbs: 2 chews; 61-100 lbs: 4 chews; Over 100 lbs: 5 chews
- Flavor: Chicken
- Quality Certifications: NASC Quality Seal, Made in USA, Veterinarian Recommended
Palatability Note: Good acceptance with natural chicken flavor. Some owners note the chews are slightly firmer than premium brands.
Considerations: Lower MSM concentration (210 mg) compared to premium options. May not be sufficient for dogs with significant joint concerns.
VetIQ Glucosamine Hip & Joint Supplement for Dogs, 180 Soft Chews, Joint Support Supplement with MSM and Krill, Dog Health Supplies Large & Small Breed, Chicken Flavored Chewables
8. Amazon Basics Dog Hip & Joint — Best for Basic Support
Amazon Basics Hip & Joint provides glucosamine, MSM, chondroitin, and green-lipped mussel in duck-flavored soft chews at Amazon’s signature value pricing, making it a solid choice for maintenance-level joint support.
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The Amazon Basics formula stands out for including green-lipped mussel, a marine source of glucosamine and natural omega-3 fatty acids. This New Zealand shellfish has been studied for its anti-inflammatory properties and joint support benefits in dogs.
While not carrying NASC certification, the product is veterinarian-reviewed and manufactured to Amazon’s quality standards. For dogs without severe joint issues who need everyday support, this represents a cost-effective daily option.
Key Specifications:
- Form: Soft Chews
- Active Ingredients: Glucosamine HCl (500 mg), MSM (400 mg), Chondroitin Sulfate, Green-Lipped Mussel, Vitamin C, Manganese
- Pet Size: All sizes
- Count: 120 soft chews
- Daily Serving: Up to 15 lbs: 1 chew; 15-45 lbs: 2 chews; 45-75 lbs: 3 chews; Over 75 lbs: 4 chews
- Flavor: Duck
- Quality Certifications: Veterinarian Reviewed
Palatability Note: Duck flavor is generally well-received. Subscribe & Save eligible for additional savings.
Considerations: Best for preventive care or mild joint support. Dogs with diagnosed joint conditions may benefit from veterinary-grade supplements with higher active ingredient concentrations.
Amazon Basics Dog Hip & Joint Daily Supplement Chews with Glucosamine, MSM, and Vitamin C, Duck Flavored, 120 Count (Previously Solimo)
9. Wuffes Advanced Hip & Joint — Best for Small Breeds
Wuffes Advanced Hip & Joint for Small & Medium Breeds delivers appropriately-dosed glucosamine, MSM, chondroitin, and green-lipped mussel in pork-flavored soft chews specifically formulated for dogs under 65 lbs.
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Small and medium breed dogs often get overlooked in the joint supplement market—most formulas are designed for large breeds with higher ingredient amounts. Wuffes addresses this gap with a formula tailored to smaller dogs’ metabolic needs and weight ranges.
The company emphasizes scientific backing, currently conducting one of the largest clinical trials in the pet joint supplement industry. Their formula includes eight active ingredients including Alaskan salmon oil for omega-3s and hyaluronic acid for joint lubrication.
Key Specifications:
- Form: Soft Chews
- Active Ingredients: Glucosamine (400 mg), MSM (200 mg), Chondroitin (50 mg), Green-Lipped Mussel (50 mg), Hyaluronic Acid (10 mg), Vitamin C (30 mg), Omega-3 from Salmon Oil, Yucca Schidigera
- Pet Size: Small to Medium (under 65 lbs)
- Count: 60 soft chews
- Daily Serving: Under 15 lbs: ½ chew; 15-35 lbs: 1 chew; 35-65 lbs: 2 chews
- Flavor: Pork
- Quality Certifications: GMP Facility, Small Business Brand
Palatability Note: Pork flavor receives excellent reviews for taste acceptance. Soft texture suitable for small mouths.
Considerations: For large breed dogs, Wuffes offers a separate Large Breed formula (available here) with higher ingredient concentrations.
Wuffes Advanced Dog Hip and Joint Supplement with Glucosamine, Chondroitin, Omega 3, MSM, and Green Lipped Mussel, 60 Pork Flavored Chews for Small and Medium Dog Breeds
MSM Dosing Guide for Dogs
MSM dosing varies by product, but general guidelines for pure MSM supplementation are:
| Dog Weight | Daily MSM Dose (Pure MSM) | Notes |
|---|---|---|
| Under 15 lbs | 50-100 mg | Start with lower dose |
| 15-30 lbs | 100-250 mg | Can split between AM/PM |
| 30-60 lbs | 250-500 mg | Most common range |
| 60-100 lbs | 500-1,000 mg | May increase for active dogs |
| Over 100 lbs | 1,000-1,500 mg | Consult vet for giant breeds |
When to Give: MSM can be given with or without food, though administering with a meal may reduce the rare occurrence of digestive upset. Many pet owners give joint supplements in the morning.
How Long Until Results: Most dogs show improvement within 2-6 weeks of consistent supplementation. Some dogs respond more quickly, while others may take up to 8 weeks to show noticeable changes in mobility and comfort.
Important: Always follow the specific dosing instructions on your chosen product, as combination supplements may have different recommended amounts than pure MSM products.
What to Look for in an MSM Supplement for Dogs
Key Active Ingredients to Prioritize:
- MSM (Methylsulfonylmethane): Look for OptiMSM or products specifying 99%+ purity. Effective doses typically range from 200-1,000 mg daily depending on dog size.
- Glucosamine HCl: Supports cartilage health and synovial fluid production. Standard doses are 500-1,500 mg for dogs.
- Chondroitin Sulfate: Works synergistically with glucosamine to protect cartilage. Usually dosed at 200-600 mg.
- Omega-3 Fatty Acids: From fish oil, krill, or green-lipped mussel; supports natural anti-inflammatory response.
Beneficial Additional Ingredients:
- ASU (Avocado/Soybean Unsaponifiables): Shown to enhance glucosamine and chondroitin effectiveness.
- Hyaluronic Acid: Supports joint lubrication.
- Boswellia Serrata: Natural anti-inflammatory herb.
- Green-Lipped Mussel: Marine source of omega-3s and natural glucosamine.
- Vitamin C & E: Antioxidants supporting connective tissue health.
Quality Certifications to Look For:
- NASC Quality Seal: The gold standard for pet supplements—indicates third-party quality audits and testing.
- GMP Certified: Manufactured in facilities following Good Manufacturing Practices.
- Made in USA: Generally indicates higher manufacturing standards and traceability.
- OptiMSM Certified: For pure MSM products, this indicates the premium distilled form.
- Veterinarian Formulated: Developed with veterinary input.
Red Flags to Avoid:
- Products without clear ingredient amounts listed
- Proprietary blends that hide individual ingredient quantities
- Missing country of origin information
- No quality certifications or third-party testing
- Unrealistic health claims
Signs Your Dog May Need an MSM Supplement
Physical Signs:
- Difficulty rising from lying down, especially after rest
- Stiffness when walking, particularly in the morning or after inactivity
- Reluctance to climb stairs, jump on furniture, or get in/out of vehicles
- Limping or favoring one leg
- Decreased activity level or loss of interest in play
- Visible joint swelling
- Muscle loss around the hips or rear legs
Behavioral Changes:
- Irritability when touched around joints
- Excessive licking of joints
- Lagging behind on walks
- Reluctance to play with other dogs or people
- Changes in posture or gait
When to Consult a Veterinarian Instead of Supplementing:
- Sudden onset lameness (could indicate injury)
- Severe joint swelling or heat
- Complete inability to bear weight on a limb
- Signs of pain that don’t improve within a few weeks
- If your dog is currently on medications
Breeds Predisposed to Joint Issues:
Certain breeds may benefit from early joint supplementation: German Shepherds, Labrador Retrievers, Golden Retrievers, Great Danes, Rottweilers, Bulldogs, Saint Bernards, Mastiffs, Dachshunds, and Basset Hounds.
Safety Considerations
Common Side Effects:
MSM is generally well-tolerated by dogs. Rare side effects may include mild digestive upset (loose stool or gas) when first starting supplementation. These typically resolve by reducing the dose temporarily and gradually increasing.
Ingredients That May Not Suit All Dogs:
- Shellfish-sourced glucosamine: Dogs with shellfish allergies should use plant-based alternatives.
- Porcine (pork) chondroitin: May not be suitable for dogs with pork sensitivities.
- Artificial flavors or preservatives: Some sensitive dogs react to additives.
Drug Interactions:
Always consult your veterinarian before starting MSM if your dog takes:
- Blood thinners (MSM may have mild blood-thinning effects)
- NSAIDs or other anti-inflammatory medications
- Prescription joint medications
- Any other supplements
Toxic Ingredient Warnings:
While MSM itself is safe, always check joint supplement labels for:
- Xylitol: Toxic to dogs—sometimes used as a sweetener in flavored supplements
- Excessive vitamin D: Can be toxic in high amounts
- Certain essential oils: Some are toxic to dogs
Pregnancy/Nursing Warning:
Safe use of MSM in pregnant or nursing dogs has not been proven. Consult your veterinarian before giving joint supplements to breeding, pregnant, or nursing animals.
Frequently Asked Questions
How long does it take to see results from MSM supplements?
Most dogs show noticeable improvement in mobility and comfort within 2-6 weeks of consistent daily use. Some dogs respond more quickly within 1-2 weeks, while others may take up to 8 weeks. The initial “loading period” of higher doses (often recommended for the first 4-6 weeks) can accelerate results.
Can I give my dog human MSM supplements?
While MSM is the same compound regardless of labeling, human MSM supplements are not recommended for dogs. Human products may contain inactive ingredients, artificial sweeteners (like xylitol, which is toxic to dogs), or dosages inappropriate for pets. Always use products specifically formulated for dogs.
Can I give this with my pet’s other medications?
Generally yes, but you should always consult your veterinarian first. MSM may have mild blood-thinning properties, which could interact with blood thinners or NSAIDs. Your vet can advise on timing and whether any dosage adjustments are needed.
What if my dog won’t eat the supplement?
Try these strategies: (1) Switch to a different flavor—duck and pork often work well for picky eaters; (2) Hide tablets in a pill pocket, cheese, or peanut butter; (3) Crush tablets or chews into wet food; (4) Try a liquid or powder form mixed into food; (5) Give the supplement as a “treat” during training sessions.
Is MSM safe for puppies?
Most manufacturers recommend joint supplements for dogs over 12 weeks of age. Puppies are still developing, and their nutritional needs differ from adult dogs. For puppies showing early joint concerns, consult your veterinarian before supplementing.
Should I give MSM alone or with glucosamine and chondroitin?
Research suggests MSM works synergistically with glucosamine—the combination may be more effective than either ingredient alone. For comprehensive joint support, a formula containing glucosamine, chondroitin, and MSM is typically recommended. Pure MSM powders are best used to supplement an existing joint care regimen.
Can MSM help with skin and coat issues?
Yes! MSM provides sulfur, which is a building block for keratin (found in skin, coat, and nails). Many pet owners report improved coat condition and reduced itching as a secondary benefit of MSM supplementation.
Is there a difference between OptiMSM and regular MSM?
OptiMSM is a branded, premium form of MSM produced in the USA using a multi-stage distillation process that ensures 99.9% purity. Generic MSM may use crystallization methods that can leave residual impurities. For dogs with sensitive systems, OptiMSM is often the safer choice.
Do joint supplements replace veterinary treatment for arthritis?
No. Joint supplements are supportive care that may help maintain joint health and comfort, but they do not replace proper veterinary diagnosis and treatment. If your dog has been diagnosed with arthritis or another joint condition, supplements should complement—not substitute for—your vet’s treatment plan.
How should I store MSM supplements?
Store in a cool, dry place away from direct sunlight. Soft chews should be kept sealed to maintain freshness and prevent hardening. Powders should be kept dry to prevent clumping. Check expiration dates and discard any supplements that have changed color, odor, or texture.
Final Verdict
Best Overall: Nutramax Dasuquin with MSM is our top recommendation for dogs needing comprehensive joint support. With 800 mg MSM, patented ASU technology, and the backing of the #1 veterinarian-recommended brand, it offers the best combination of quality, effectiveness, and research support.
Best Value: VetIQ Hip & Joint provides NASC-certified quality at a budget-friendly price, making daily joint support accessible without compromising on safety or manufacturing standards.
Best for Picky Eaters: Zesty Paws Mobility Bites consistently wins on palatability, with duck-flavored soft chews that most dogs eagerly accept as treats.
Whichever product you choose, consistency is key—daily supplementation over several weeks gives MSM the best chance to support your dog’s joint health and mobility.
