Best Supplements for Spider Veins (2026) – Top 10 Reviewed
Spider veins are those small, web-like clusters of red, blue, or purple veins that appear close to the skin’s surface, most commonly on the legs and face. While they’re usually harmless, many people seek ways to reduce their appearance and prevent new ones from forming. This guide reviews the best supplements for supporting vein health and minimizing spider veins.
Our Top Picks at a Glance
- Best Overall: Diosmin Hesperidin Complex – clinically studied for capillary strength
- Best Value: Natures Craft Vein Support – comprehensive formula at great price
- Best for Capillaries: Vital Peak Vein Care – rutin-focused formula
Quick Comparison
| Product | Key Ingredients | Form | Servings | Best For |
|---|---|---|---|---|
| Diosmin Hesperidin 1000mg | Diosmin, Hesperidin | Capsules | 60 | Clinical-strength support |
| Natures Craft Vein Support | Horse Chestnut, Rutin | Capsules | 60 | Best value |
| Vital Peak Vein Care | Rutin, Horse Chestnut | Capsules | 60 | Capillary strength |
| We Like Vitamins Vein Vitality | Diosmin, Horse Chestnut, Vitamin K2 | Capsules | 60 | Comprehensive formula |
| We Like Vitamins Diosmin Hesperidin | Diosmin, Hesperidin | Capsules | 180 | Long-term supply |
| Natural Factors Horse Chestnut | Horse Chestnut, Grape Seed | Capsules | 60 | Antioxidant support |
| VAITE Horse Chestnut Gummies | Horse Chestnut, Butcher’s Broom | Gummies | 60 | Gummy preference |
| Supersmart Horse Chestnut | Horse Chestnut (20% Aescin) | Capsules | 60 | Standardized extract |
1. Diosmin Hesperidin 1000mg Complex – Best Overall
- What's Inside - Each 2 capsule serving features nearly 500mg hesperidin plus diosmin 500mg from Citrus Aurantium extract which are high potency bioflavonoids that help keep your pathways flowing
- Vegan Non-GMO Formula - We use carefully sourced bitter orange in our diosmin hesperidin supplements to give you a quality tested herbal formula that is easy to take and offers a variety of benefits
- Improve your Flow Head to Toe - Ditch those artificial circulation supplements and try our carefully crafted formula made to help prevent leakage and backups in the veins while promoting CVI relief
- Trusted Brand - Choose Nature's Craft and our carefully sourced antioxidant supplement for men and women made in the USA in GMP facility and 3rd party lab tested for quality control you can trust
- Nature's Craft Quality - We are proud to be a leading name in a variety of vein support supplements with potent plant based ingredients because we know Mother Nature is our best ally for wellness
This potent bioflavonoid combination strengthens capillaries and reduces the appearance of spider veins from the inside out.
Diosmin and hesperidin work synergistically to improve microcirculation and reduce capillary permeability—the underlying causes of spider vein formation. Clinical studies show these citrus bioflavonoids can strengthen vessel walls and improve overall vascular integrity when taken at 1000mg daily.
What We Like
- Clinical-strength 1000mg dose proven effective in studies
- Specifically targets capillary fragility
- May reduce appearance of existing spider veins
- Supports prevention of new spider vein formation
What Could Be Better
- Results require consistent 8-12 week use
- Works best when combined with topical treatments
Bottom Line: The most research-backed option for strengthening capillaries and addressing spider veins at their source.
2. Natures Craft Vein Support Supplements – Best Value
- Leg Vein Supplement - Say hello to better looking leg veins with our enhanced circulation and vein support complex designed to promote clear passageways and improve comfort with trusted ingredients
- Improve your Flow Head to Toe - Ditch those outdated circulation supplements and try our carefully crafted formula designed to help prevent leakage and backups in the veins while promoting CVI relief
- Powered by Horse Chestnut - Our body and leg circulation supplement is based on the tried and true horse chestnut thanks to its remarkable antioxidant profile including flavonoids and saponins
- Clean Formula - We are proud to feature superstar vegan ingredients like Vitamin E Gotu Kola Rutin and Grapeseed extract but we are also proud to exclude Magnesium stearate and Silicon dioxide
- Nature's Craft Quality - We are proud to be a leading name in a variety of heart health supplements with potent plant based ingredients because we know Mother Nature is our best ally for wellness
An affordable multi-ingredient formula that delivers spider vein support without breaking the bank.
This vegan supplement combines horse chestnut extract with vitamin E, gotu kola, rutin, and grape seed extract. Each ingredient contributes to vascular health—horse chestnut tones veins, rutin strengthens capillaries, and grape seed provides antioxidant protection. The clean formula excludes common fillers.
What We Like
- Multiple complementary ingredients for comprehensive support
- Excellent price point for quality formula
- Vegan-friendly and free from unnecessary additives
- Contains rutin specifically beneficial for spider veins
What Could Be Better
- Doesn’t specify exact standardization levels
- Lower dose than some premium options
Bottom Line: The best value option offering multiple beneficial ingredients in one affordable supplement.
3. Vital Peak Vein Care Blend – Best for Capillary Strength
- COMPREHENSIVE CIRCULATION AND VEIN SUPPORT: Each serving delivers a synergistic blend of natural ingredients formulated to support vascular integrity, healthy blood flow, and overall leg comfort throughout the day.*
- RESEARCHED INGREDIENTS: Vein Care Blend combines 4 powerful ingredients including Horse Chestnut Extract, Rutin, Butcher's Broom, and Micronized Citrus Flavonoids to support healthy leg veins and circulation.*
- FOR LEG COMFORT: Our advanced vein formula features standardized Horse Chestnut (20% Aescin) and Micronized Citrus Flavonoids that work together to support vein tone and comfort in the lower extremities.*
- TRADITIONAL VEIN SUPPORT: Butcher's Broom extract and Rutin (from Sophora japonica flower buds) have been used for centuries to promote healthy leg veins and help maintain proper circulation to the lower body.*
- TRUSTED QUALITY: Made in the USA in an SQF-certified facility in compliance with cGMP/GMP requirements, using US and foreign ingredients. This supplement is vegetarian, non-GMO, and gluten-free.
This rutin-focused formula specifically targets the capillary weakness that leads to spider veins.
Vital Peak emphasizes rutin, a bioflavonoid particularly effective at reducing capillary fragility and permeability. Combined with horse chestnut and other circulation-supporting ingredients, it addresses spider veins by strengthening the tiny blood vessels where they form most frequently.
What We Like
- High rutin content for maximum capillary support
- Includes horse chestnut for vein toning
- Targets both spider veins and early varicose veins
- Clean, focused ingredient list
What Could Be Better
- Newer brand with limited customer reviews
- May require higher dose for severe cases
Bottom Line: Excellent choice for those specifically seeking rutin’s capillary-strengthening benefits against spider veins.
4. We Like Vitamins Vein Vitality 1250mg – Best Comprehensive Formula
- Enhanced Circulation: Elevate leg health with our Diosmin Complex, supporting improved blood flow for vibrant legs, healthy leg circulation and capillaries, lymphatic drainage & hemorrhoid relief. It supports relief from spider veins & varicose veins
- Best Varicose Veins Treatment: Our Diosmin Hesperidin 1250mg vein support supplement combines Citrus Bioflavonoids, Horse Chestnut Extract, Butcher's Broom Extract and Vitamin K2 to support healthy legs &
- Vein Support for Varicose & Spider Veins: Beyond its circulatory advantages, the Diosmin Complex offers comprehensive relief for spider veins and varicose veins. Address Spider & Varicose Veins, remove varicose veins, spider vein treatment for legs.
- USA-Manufactured Quality: Our Hesperidin & Diosmin Complex 1250mg is Vegan and Gluten-Free in a GMP-certified facility using only the highest quality ingredients. Manufactured in the USA ensures the highest standards of quality and safety.
- Satisfaction Assurance: Experience the benefits of premium leg vein support without compromise. Assured satisfaction or your credit back, if you're not completely satisfied with it for any reason.
This premium formula combines the most effective spider vein ingredients into one comprehensive supplement.
Vein Vitality delivers 1250mg of diosmin and hesperidin complex alongside horse chestnut extract, butcher’s broom, citrus bioflavonoids, and vitamin K2. This multi-pronged approach addresses spider veins through improved capillary strength, reduced inflammation, and enhanced circulation.
What We Like
- Highest potency diosmin hesperidin formula
- Includes vitamin K2 for vascular health
- USA-manufactured with quality certifications
- Addresses multiple causes of spider veins simultaneously
- Vegan and gluten-free formulation
What Could Be Better
- Premium pricing reflects comprehensive formula
- Requires multiple capsules per serving
Bottom Line: The most complete spider vein formula available for those wanting maximum ingredient variety and strength.
5. We Like Vitamins Diosmin Hesperidin 1000mg – Best Long-Term Supply
- MAXIMUM STRENGTH DIOSMIN - HESPERIDIN 1000mg – Our Proprietary Blend contains 1000mg of Diosmin & Hesperidin per capsule, 2 capsules per serving.
- BEST VALUE DIOSMIN HESPERIDIN ON AMAZON -180 Capsules- 90 DAY SUPPLY – Each bottle contains 180 Capsules. Others offer fewer capsules, pills, tablets, or softgels only 60, 90, or 120 at a higher price.
- GET HEALTHIER TODAY – Diosmin & Hesperidin are both types of plant chemicals found mainly in citrus fruits. They are both classified as bioflavonoids.
- BENEFITS OF MAX STRENGTH DIOSMIN & HESPERIDIN 1000mg – Diosmin Hesperidin supplements helps support lymphatic drainage, along with helping to support healthy veins, capillaries and circulation.
- HIGH QUALITY DIOSMIN & HESPERIDIN – Our Diosmin Hesperidin supplement is free of preservatives and artificial ingredients. All of our products are encapsulated and bottled in the USA with ingredients sourced from around the world. Using Diosmin Hesperidin Capsules from We Like Vitamins is a great start to a healthier lifestyle.
A straightforward diosmin hesperidin supplement with a generous 180-capsule supply for extended use.
This product provides the proven 1000mg dose of diosmin and hesperidin in a value-sized bottle. The 90-day supply is ideal for those committed to long-term vascular support, as spider vein improvements typically require several months of consistent supplementation.
What We Like
- Generous 90-day supply saves money long-term
- Clinical-strength 1000mg daily dose
- Simple, focused formula without unnecessary additives
- Research-backed ingredients
What Could Be Better
- Contains only two primary ingredients
- Larger bottle size may not suit everyone
Bottom Line: Perfect for those who want a straightforward diosmin formula with excellent value for long-term use.
6. Natural Factors Horse Chestnut with Grape Seed – Best Antioxidant Support
- Standardized herbal extracts that support circulation.
- Superior combination of standardized herbal extracts that benefit varicose veins.
- Support for healthy veins and capillaries.
- Superior combination of standardized herbal extracts that benefit varicose veins, chronic venous insufficiency, hemorrhoids and edema.
- Helps to inhibit these damaging enzymes, increases the tone of the veins and improves return blood flow to the heart.
This trusted combination provides horse chestnut’s vein-toning benefits with grape seed’s powerful antioxidant protection.
Natural Factors pairs standardized horse chestnut extract with grape seed extract to support capillary integrity while protecting against oxidative damage. This dual approach helps maintain healthy microcirculation and may reduce the visibility of spider veins over time.
What We Like
- Standardized horse chestnut with verified aescin content
- Grape seed offers additional capillary protection
- Established brand with quality reputation
- Supports overall vascular health
What Could Be Better
- Contains only two main ingredients
- May work more slowly than diosmin-based formulas
Bottom Line: A quality choice for those preferring horse chestnut over diosmin, from a reputable supplement manufacturer.
7. VAITE Horse Chestnut Extract Gummies – Best Gummies
- OPTIMAL LEG WELLNESS - Experience improved leg comfort with our Horse Chestnut Extract Gummies. Formulated with a blend, these gluten-free, vegan-friendly gummies offer support for vein health, promoting overall well-being
- SUPPORTS HEALTH CHEWS - This Horse Chestnut Gummies provide essential support for leg and vein health. Enjoy the benefits of a high-quality, non-GMO, vegan supplement designed to enhance your comfort and vitality with each delicious gummy
- VEIN SUPPORT - Boost your leg health with our Horse Chestnut Extract Gummies. Perfect for daily use, these vegan, gluten-free chews are crafted to support overall vein function, helping you stay active and comfortable
- CHEWY CANDIES TO IMPROVE AND SUPPORT - Discover the benefits of horse chestnut with our vegan chewy candies designed to improve vein and leg health. These non-GMO and gluten-free chewy candies support vein and are a delicious way to improve your daily life
- SUPPORT LEG HEALTH - these chewable candies with horse chestnut extract are a natural choice for supporting leg and vein health. With a vegan formula these chewy candies help support vein health by offering a tasty and effective supplement
These convenient gummies make daily vein support enjoyable with horse chestnut and butcher’s broom.
VAITE delivers spider vein support in a tasty gummy format, perfect for those who struggle with swallowing pills. Each serving provides horse chestnut seed extract and butcher’s broom root in a vegan-friendly, non-GMO formula.
What We Like
- Easy-to-take gummy format increases compliance
- Combines two proven vein-supporting botanicals
- Vegan, gluten-free, and non-GMO certified
- Pleasant taste makes daily use easier
What Could Be Better
- Contains added sugars inherent to gummies
- Lower active ingredient concentration than capsules
Bottom Line: The best option for those who prefer gummies or have difficulty with traditional capsules.
8. Supersmart Horse Chestnut Extract 500mg – Best Standardized Extract
- HORSE CHESTNUT CAPSULES - This horse chestnut supplement contains the active substance aescin, highly standardized with potent effects on healthy vein.*
- CIRCULATION & VEINS - Natural pills that supports healthy circulation, and helps with "heavy legs" feelings and veins appearance.*
- NON-GMO, GLUTEN FREE, VEGETARIAN FRIENDLY - Supersmart offers you an outstanding quality and choice of supplements for women and men, difficult to find elsewhere.
- Recommended Use - Take 2 capsules a day. Each capsule contains 250mg of horse chestnut. Contains horse chestnut extract standardized to provide 20% escin | Other ingredients: acacia gum, white rice bran.
- 100% Satisfaction - Money Back Guarantee - Since 1992, we want you to be fully satisfied. No questions asked, money back guarantee. Ping us 24/7 regarding any questions you may have.
A high-quality, standardized horse chestnut supplement with 20% aescin content for reliable potency.
Supersmart delivers 500mg of horse chestnut extract per day, standardized to provide exactly 20% aescin—the active compound responsible for vein-toning effects. This standardization ensures consistent potency from batch to batch, which is crucial for addressing spider veins effectively.
What We Like
- Precisely standardized to 20% aescin content
- European quality manufacturing standards
- Vegetarian-friendly capsules
- Non-GMO and gluten-free
What Could Be Better
- Contains only horse chestnut (no complementary ingredients)
- Requires two capsules daily
Bottom Line: An excellent choice for those specifically seeking standardized horse chestnut at a therapeutic dose.
How to Choose the Best Supplement for Spider Veins
When selecting a spider vein supplement, you’ll want to focus on ingredients that specifically strengthen capillaries and reduce their fragility. Rutin is particularly important for spider veins because it targets the tiny blood vessels where these visible veins form. Look for products providing at least 500mg of rutin daily for optimal capillary support.
Diosmin and hesperidin are equally valuable, with extensive research showing they reduce capillary permeability and improve microcirculation. These citrus bioflavonoids work at the cellular level to strengthen blood vessel walls and reduce inflammation. Choose formulas offering 900-1000mg combined daily dose to match clinical study amounts.
Horse chestnut extract standardized to 16-20% aescin content can help tone veins and reduce the fluid leakage that makes spider veins more visible. While more commonly associated with varicose veins, horse chestnut’s anti-inflammatory properties benefit spider veins too, especially when combined with capillary-strengthening ingredients like rutin.
Consider formulas that combine multiple beneficial ingredients rather than single-ingredient supplements. Spider veins often have multiple contributing factors—weak capillaries, inflammation, poor circulation—so comprehensive formulas addressing all these issues tend to produce better results. Look for combinations that include diosmin, rutin, horse chestnut, and vitamin K2 for maximum benefit.
Pay attention to dosage forms and daily serving requirements. Some products achieve therapeutic doses in one or two capsules, while others require three or four daily. Consider your preference for capsules versus gummies, keeping in mind that capsules typically deliver higher concentrations of active ingredients.
Benefits of Spider Vein Supplements
Spider vein supplements work by addressing the underlying capillary weakness that allows these small vessels to become visible through the skin. Unlike topical treatments that only address surface appearance, internal supplements strengthen blood vessel walls from within, potentially reducing both existing spider veins and preventing new ones from forming.
Research on bioflavonoids like diosmin, hesperidin, and rutin shows they can significantly improve capillary resistance and reduce permeability. This means the tiny blood vessels become less fragile and less likely to dilate or become visible under the skin. Clinical studies demonstrate that consistent supplementation over 8-12 weeks can reduce the appearance of spider veins and improve overall vascular health.
Beyond cosmetic improvements, these supplements address the symptoms often associated with spider veins, including leg aching, burning sensations, and restless legs. By improving overall circulation and reducing inflammation in small blood vessels, many people experience relief from discomfort even before seeing visible improvements in vein appearance.
Spider vein supplements also offer preventive benefits. If you’re genetically predisposed to spider veins or have risk factors like prolonged standing or sitting, pregnancy, or age, taking these supplements proactively may help prevent or delay their development. The capillary-strengthening effects provide ongoing protection against the vessel fragility that leads to spider vein formation.
Frequently Asked Questions
What is the most effective supplement for spider veins?
Diosmin and hesperidin combined at 900-1000mg daily is considered most effective based on clinical research. Rutin is particularly beneficial for spider veins because it specifically strengthens capillaries. The most effective approach often combines these bioflavonoids with horse chestnut for comprehensive capillary and vein support.
How long does it take for supplements to reduce spider veins?
Most people notice improvements in symptoms like aching or burning within 4-6 weeks, but visible reduction in spider vein appearance typically takes 2-4 months of consistent use. Spider veins are small and respond more slowly than larger varicose veins. Best results come from combining supplements with proper skin protection and lifestyle modifications.
Can supplements completely eliminate spider veins?
Supplements can reduce the appearance of spider veins and prevent new ones from forming, but they rarely eliminate existing spider veins completely. They work by strengthening capillaries and improving circulation, which can make veins less visible over time. For complete removal, you’ll need treatments like sclerotherapy or laser therapy, though supplements can help prevent recurrence after these procedures.
Should I take rutin or diosmin for spider veins?
Both are beneficial, but rutin specifically targets capillary fragility which is the primary issue in spider veins. Diosmin excels at reducing inflammation and improving overall venous tone. The ideal approach is a formula containing both ingredients, as they work synergistically—rutin strengthens the tiny vessels while diosmin improves circulation and reduces permeability.
Are spider vein supplements safe for facial spider veins?
Yes, these supplements work systemically throughout your entire vascular system, including facial capillaries. However, facial spider veins may respond more slowly than leg spider veins because facial skin is thinner and more delicate. Be patient and consistent, and consider combining oral supplements with topical vitamin K creams for facial spider veins.
Can I take spider vein supplements during pregnancy?
You should always consult your healthcare provider before taking any supplement during pregnancy. While ingredients like diosmin are sometimes used for hemorrhoids during pregnancy, proper medical guidance is essential. Spider veins that develop during pregnancy often improve naturally within 3-4 months after delivery without supplementation.
Do I need to avoid sun exposure while taking these supplements?
Spider vein supplements don’t typically increase sun sensitivity, but sun exposure can worsen spider veins by damaging small blood vessels. Continue using sunscreen and protecting your skin regardless of supplementation. Some people find that combining sun protection with these supplements produces better results for facial spider veins.
What lifestyle changes help spider vein supplements work better?
Exercise regularly to improve overall circulation, especially activities that engage your leg muscles like walking or cycling. Avoid prolonged standing or sitting by taking movement breaks every hour. Elevate your legs when resting, maintain a healthy weight, and wear sunscreen to protect facial skin. Stay hydrated and consider compression stockings if you stand for long periods. These habits enhance the effects of your supplements.
