Best Supplements for Tooth Pain (2026) – Top 10 Reviewed

Tooth pain can strike suddenly and severely, making it difficult to eat, sleep, or focus on daily activities. While professional dental care is essential for addressing the underlying cause, the right supplements and topical treatments can provide much-needed relief while you wait for your appointment or manage chronic dental sensitivity. This guide reviews the most effective tooth pain supplements and treatments available, from traditional benzocaine formulas to natural anti-inflammatory options that support oral health from within.

Our Top Picks at a Glance

• Best Overall: Red Cross Toothache Kit – Natural clove oil for instant relief
• Best Instant Relief: DenTek Instant Pain Relief – Precise benzocaine application
• Best Natural: DOLODENT Tooth Pain Drops – Homeopathic formula

Quick Comparison

Product	Active Ingredient	Application	Relief Time	Best For
Red Cross Toothache Kit	85% Eugenol (Clove Oil)	Cotton pellet	Instant	Cavity pain
DenTek Instant Relief	20% Benzocaine	Disposable applicator	Instant	Precise application
DOLODENT Pain Drops	Natural Homeopathic	Oral spray	15 minutes	Natural relief
Odontic Health Herbal	Chinese Herbs	Capsules	30-60 minutes	Inflammation
Oral Probiotics	Probiotics & Prebiotics	Chewable	Long-term	Oral health support
Electric Toothbrush/Flosser	Mechanical cleaning	Brush & floss	Prevention	Plaque removal
Cordless Water Flosser	Water pressure	U-shaped flossing	Prevention	Gum sensitivity

1. Red Cross Toothache Medicine Kit – Best Overall

→ Check Price on Amazon

Red Cross Toothache Kit provides instant, long-lasting relief using 85% eugenol (natural clove oil), the same ingredient dentists have trusted for centuries.

This complete kit includes the medicated liquid, cotton pellets, and tweezers for precise application directly into cavities without touching surrounding tissue. Clove oil has natural numbing and anti-inflammatory properties that work at the root of toothache pain, providing relief that can last for hours. The controlled application method ensures you target only the affected tooth while minimizing irritation to healthy gums. Red Cross has been a trusted name in oral pain relief for generations, and this kit is essential for any medicine cabinet or travel first aid supplies.

What We Like

• 85% eugenol concentration delivers powerful, natural pain relief
• Complete kit with tweezers and cotton pellets for precise, controlled application
• Used by dentists for centuries, proven effective for cavity pain
• Provides instant relief that can last several hours

What Could Be Better

• Strong clove taste may be intense for some users
• Can cause burning sensation if it contacts surrounding gum tissue

Bottom Line: For severe, throbbing toothache pain from cavities, Red Cross delivers the most powerful and immediate natural relief available over the counter.

2. DenTek Instant Oral Pain Relief with Benzocaine – Best Instant Relief

→ Check Price on Amazon

DenTek’s disposable applicator system delivers 20% benzocaine precisely where you need it without the mess or risk of contaminating your medication.

This advanced kit features 50 single-use applicators with ergonomic handles that reach any area of your mouth easily. The maximum strength benzocaine formula provides the instant numbing power that dentists recommend for toothaches, sore gums, canker sores, and cold sores. The fresh mint flavor makes application more pleasant while the no-fingers, no-mess design ensures hygienic use every time. Each applicator measures exactly one dose, eliminating guesswork and preventing waste.

What We Like

• 50 disposable applicators ensure sterile, mess-free application every time
• 20% benzocaine is maximum strength for instant numbing relief
• Ergonomic handle design reaches difficult areas easily
• Fresh mint flavor improves the application experience

What Could Be Better

• Single-use applicators create more waste than reusable options
• Relief duration may be shorter than clove oil treatments

Bottom Line: For clean, convenient, and precise application of maximum strength pain relief, DenTek’s disposable applicator system is unmatched in ease of use.

3. DOLODENT Tooth Pain Relief Drops – Best Natural Formula

→ Check Price on Amazon

DOLODENT combines arnica montana, chamomilla, hecla lava, and hypericum in a natural homeopathic formula that relieves tooth and gum pain without harsh chemicals.

This oral spray offers a gentler approach to dental pain relief, using time-tested homeopathic ingredients that reduce inflammation, calm nerve pain, and soothe irritated tissues. The formula addresses multiple types of oral discomfort including toothaches, gum swelling, bone pain, and neuralgia. The convenient spray format stores at room temperature and fits easily in a purse or pocket for on-the-go relief. It’s formulated with natural ingredients and doesn’t contain the potentially harmful chemicals found in some conventional pain relievers.

What We Like

• Natural homeopathic ingredients provide gentle pain relief
• Addresses multiple oral pain issues including teeth, gums, and nerves
• Convenient spray format for easy application anywhere
• Free from harsh chemicals and synthetic pain relievers

What Could Be Better

• Effects may take longer to appear than conventional pain relievers
• Homeopathic formulas have less clinical research than pharmaceutical options

Bottom Line: If you prefer natural remedies or have sensitivity to conventional pain medications, DOLODENT offers effective relief through homeopathic ingredients.

4. Odontic Health Toothache Herbal Supplement – Best for Inflammation

→ Check Price on Amazon

This traditional Chinese herbal formula combines dandelion, angelica, rehmannia, and other herbs used for centuries to relieve dental pain and swelling.

Odontic Health takes a systemic approach to tooth pain by addressing inflammation throughout the body. The herbal blend includes dandelion for its anti-inflammatory properties, dahurian angelica for pain relief, rehmannia for nourishing tissues, anemarrhena for clearing heat, skullcap for calming nerves, and rhubarb for its medicinal benefits. While it works more gradually than topical anesthetics, this supplement supports overall oral health and can be particularly effective for pain caused by inflammation rather than acute injury.

What We Like

• Traditional Chinese herbal formula with centuries of use
• Addresses inflammation and pain from a systemic perspective
• Supports overall teeth and gum health, not just pain relief
• Made in USA with quality herbal ingredients

What Could Be Better

• Takes longer to work than instant topical pain relievers
• Capsule format may be difficult when experiencing severe mouth pain

Bottom Line: For chronic dental inflammation or those seeking a holistic approach, this herbal supplement addresses the root causes of tooth pain rather than just masking symptoms.

5. Oral Probiotics Supplement with Prebiotics – Best Long-Term Support

→ Check Price on Amazon

This probiotic supplement supports healthy teeth and gums by promoting beneficial bacteria that naturally reduce inflammation and prevent dental problems.

While not a direct pain reliever, oral probiotics work preventively and therapeutically by improving your oral microbiome. Beneficial bacteria strains help crowd out harmful bacteria that cause tooth decay, gum disease, and associated pain. The addition of prebiotics feeds these good bacteria, allowing them to establish and maintain a healthy presence in your mouth. Regular use can reduce sensitivity, improve gum health, and decrease the frequency of dental pain episodes. The chewable format also freshens breath while delivering these benefits.

What We Like

• Addresses root causes by promoting healthy oral bacteria balance
• Prebiotics support long-term bacterial health in the mouth
• Helps prevent future dental pain rather than just treating symptoms
• Convenient chewable format integrates easily into daily routine

What Could Be Better

• Does not provide immediate pain relief for acute toothaches
• Requires consistent daily use to see preventive benefits

Bottom Line: For preventing tooth pain and supporting overall oral health, probiotics offer a modern, science-backed approach that works with your body’s natural defenses.

6. Electric Toothbrush with Water Flosser Combo – Best Prevention Tool

→ Check Price on Amazon

This professional 2-in-1 system combines sonic brushing with water flossing to remove the plaque and bacteria that cause tooth pain and sensitivity.

While not a supplement, this advanced cleaning system addresses the primary cause of dental pain: plaque buildup and gum inflammation. The sonic toothbrush delivers up to 42,000 vibrations per minute to break up plaque, while the integrated water flosser uses adjustable pressure to clean deep between teeth and below the gum line where pain often originates. By preventing plaque accumulation, you reduce the bacterial infection that leads to cavities, gum disease, and resulting tooth pain.

What We Like

• Two essential oral care tools in one convenient device
• Water flossing reaches areas brushing alone cannot clean
• Prevents plaque buildup that causes most dental pain
• Multiple modes accommodate sensitive teeth and gums

What Could Be Better

• Requires regular charging and maintenance
• Learning curve for proper water flosser technique

Bottom Line: For long-term tooth pain prevention, superior oral hygiene through advanced cleaning technology is your best defense against future dental problems.

7. Cordless Water Flosser with U-Shaped Design – Best for Sensitive Gums

→ Check Price on Amazon

This innovative U-shaped flosser provides 360-degree deep cleaning while being gentle enough for painful or sensitive gums.

The unique design offers five cleaning modes and seven jet tips to customize your experience based on sensitivity levels and cleaning needs. For those experiencing gum pain or tooth sensitivity, the gentler modes provide effective cleaning without aggravating inflamed tissues. Regular water flossing removes trapped food particles and bacteria that contribute to pain while stimulating healthy gum tissue. The cordless, portable design makes it easy to maintain your oral hygiene routine anywhere.

What We Like

• U-shaped design provides comprehensive 360-degree cleaning
• Five modes allow gentle cleaning for sensitive or painful areas
• Removes debris that causes pain without harsh scrubbing
• Cordless and portable for travel or convenience

What Could Be Better

• May require practice to achieve optimal technique
• Not a direct pain reliever, works preventively

Bottom Line: If tooth pain stems from gum sensitivity or inflammation, this gentle water flosser cleans thoroughly while minimizing discomfort during your oral care routine.

How to Choose the Best Supplements for Tooth Pain

Selecting the right tooth pain treatment depends on understanding the source and severity of your pain. For acute, severe toothache from a cavity or infection, you’ll want immediate topical relief from products containing eugenol (clove oil) or benzocaine. These work within seconds to numb pain at the source. If your pain is more diffuse or related to gum inflammation, natural anti-inflammatory supplements or homeopathic remedies may address the underlying cause while providing gradual relief.

Consider the application method that will work best for your situation. Kits with cotton pellets and tweezers allow precise placement in cavities but require steady hands and good visibility. Disposable applicators offer convenience and hygiene but may be harder to target specific spots. Sprays and liquids provide ease of application but less control over dosage and placement. Capsules and chewables work systemically and are ideal for ongoing support rather than acute relief.

Think about whether you prefer natural or conventional approaches. Clove oil is natural but powerful, with a strong taste and potential for irritation if misapplied. Benzocaine is synthetic but FDA-regulated with well-established safety and efficacy. Homeopathic and herbal options offer the gentlest approach but typically require longer to show effects. Some people benefit from combining approaches—using topical relief for immediate pain management while taking supplements to address underlying inflammation.

Remember that over-the-counter pain relief is temporary and should not replace professional dental care. Persistent tooth pain always requires evaluation by a dentist to identify and treat the underlying cause. Look for products from reputable brands with clear labeling of active ingredients and concentrations. If you have allergies to specific ingredients like benzocaine or are taking blood thinners, consult your healthcare provider before using new pain relief products.

Benefits of Supplements for Tooth Pain

Tooth pain supplements and treatments provide crucial relief while you await dental care or manage chronic sensitivity. The primary benefit is immediate pain reduction through numbing agents like benzocaine or eugenol, which block nerve signals from the affected tooth to your brain. This can transform unbearable pain into manageable discomfort, allowing you to eat, sleep, and function normally while addressing the underlying dental issue.

Natural anti-inflammatory supplements like turmeric, omega-3 fatty acids, and herbal formulas work differently by reducing the inflammation that often causes or worsens dental pain. While they take longer to provide relief than topical anesthetics, they address root causes rather than just masking symptoms. These supplements can be particularly beneficial for chronic conditions like gum disease, where ongoing inflammation contributes to persistent discomfort. Some studies suggest that omega-3s and curcumin can reduce inflammatory markers associated with periodontal disease.

Preventive supplements and tools offer perhaps the greatest long-term benefit by reducing the frequency and severity of tooth pain episodes. Probiotics support a healthy oral microbiome, crowding out the harmful bacteria that cause cavities and gum disease. Advanced cleaning tools like water flossers remove the plaque and food debris that lead to bacterial growth and inflammation. By maintaining better oral health baseline, you can minimize dental problems before they escalate to painful conditions.

Many tooth pain treatments also provide secondary benefits beyond pain relief. Clove oil has natural antimicrobial properties that can help fight infection. Benzocaine can reduce sensitivity that makes eating or drinking uncomfortable. Oral probiotics improve breath freshness while supporting gum health. Even the act of properly cleaning your teeth with advanced tools can reduce overall sensitivity by removing irritating plaque and strengthening gum tissue through gentle stimulation.

Frequently Asked Questions

How quickly do tooth pain supplements work?

Topical treatments with benzocaine or clove oil work almost instantly—typically within 30 seconds to 2 minutes—by numbing the affected area. Homeopathic sprays like DOLODENT may take 15-30 minutes to show effects. Herbal supplements in capsule form usually require 30-60 minutes as they must be digested and absorbed before providing systemic anti-inflammatory benefits. Probiotics and preventive supplements work over weeks to months by gradually improving oral health rather than providing acute pain relief. For immediate needs, always choose topical anesthetics; for long-term management, combine with systemic supplements.

Can I use tooth pain supplements instead of seeing a dentist?

No, tooth pain supplements should never replace professional dental care. They provide temporary symptom relief but do not treat the underlying cause—whether that’s a cavity, abscess, cracked tooth, or gum disease. Untreated dental problems typically worsen over time and can lead to serious complications including tooth loss, bone damage, or systemic infection. Use supplements to manage pain while scheduling and waiting for your dental appointment, but always seek professional evaluation for persistent or severe tooth pain. Your dentist can identify the source and provide definitive treatment.

Are natural tooth pain remedies as effective as benzocaine?

Natural remedies like clove oil (eugenol) can be just as effective as benzocaine for numbing tooth pain, which is why dentists have used eugenol for centuries. In fact, the Red Cross kit with 85% eugenol often provides longer-lasting relief than benzocaine products. However, other natural remedies like herbal supplements and homeopathic treatments work differently and more gradually, focusing on reducing inflammation rather than numbing nerves. They may be “effective” for their intended purpose but won’t provide the instant numbing that benzocaine or eugenol deliver. The best choice depends on whether you need immediate topical relief or systemic anti-inflammatory support.

Can I use multiple tooth pain treatments together?

You can generally combine different types of treatments safely, but avoid using multiple topical anesthetics simultaneously as this increases risk of overdose or adverse reactions. For example, you could use a clove oil treatment for immediate relief while taking an anti-inflammatory herbal supplement for ongoing inflammation management, or use probiotics daily while applying benzocaine as needed for acute pain. However, do not apply both benzocaine and eugenol products at the same time. Always follow dosage instructions, and if you’re taking prescription medications or have medical conditions, consult your healthcare provider before combining treatments.

What’s the difference between tooth pain from cavities versus sensitivity?

Cavity pain is typically sharp, localized to a specific tooth, and often worsens with pressure, hot/cold, or sweet foods. It may be constant or throbbing and indicates bacterial infection destroying tooth structure. Sensitivity pain is usually brief, triggered specifically by temperature or sweet/acidic foods, and affects the exposed root surface rather than the tooth interior. Sensitivity responds well to desensitizing toothpastes and gentle cleaning, while cavity pain requires topical anesthetics for temporary relief and professional filling or extraction for cure. If you can pinpoint exactly which tooth hurts, it’s more likely a cavity or crack; diffuse discomfort across multiple teeth suggests sensitivity or gum issues.

How long can I safely use tooth pain relief products?

Most topical benzocaine and eugenol products should not be used for more than 7 days without consulting a dentist, as persistent pain indicates a dental problem requiring professional treatment. Using these products longer masks symptoms of worsening conditions that could lead to serious complications. Natural anti-inflammatory supplements and probiotics can typically be used long-term as directed, as they support overall health rather than just numbing pain. However, if you find yourself relying on any pain relief product daily for more than a week, it’s essential to get dental evaluation—the goal is to fix the problem, not just manage the symptoms indefinitely.

Do tooth pain supplements have side effects?

Common side effects include temporary numbness beyond the treated area, altered taste, mild burning or tingling, and possible allergic reactions. Benzocaine can rarely cause methemoglobinemia (a blood disorder) especially in children, which is why age restrictions exist. Eugenol can irritate gum tissue if it contacts healthy areas. Herbal supplements may interact with blood thinners or other medications. Probiotics are generally very safe but may cause initial digestive adjustment. Always read warning labels, check for allergy alerts, and discontinue use if you experience unusual symptoms. Pregnant or nursing women should consult healthcare providers before using any oral pain relief products.

Can children use tooth pain supplements?

Age restrictions vary by product. Many benzocaine and eugenol products are approved for children 12 and older, while some homeopathic remedies may be safe for younger ages under supervision. However, children under 2 should never use these products without specific direction from a pediatric dentist or doctor. For young children experiencing tooth pain, acetaminophen or ibuprofen appropriate for their age and weight is usually the safer choice while arranging prompt dental care. Never apply adult-strength topical anesthetics to children’s teeth, and always supervise use to prevent swallowing. Tooth pain in children often indicates cavities or emerging teeth and should be evaluated by a dentist promptly.

Related Articles

• Best Turmeric Curcumin Gummies
• Best Turmeric Supplements
• Best Omega-3 Fish Oil Supplements
• Best Probiotic Supplements
• Best Immune Support Supplements