Best Mulberry Leaf Supplements (2026) – Top 10 Reviewed
Mulberry leaf has been used in traditional medicine for centuries to support healthy blood sugar levels, and modern research continues to validate its effectiveness. If you’re looking for a natural way to help manage glucose metabolism, you’ll find that mulberry leaf supplements offer a plant-based approach backed by science. This guide covers the top mulberry leaf products available, from standardized extracts to convenient combination formulas.
Our Top Picks at a Glance
- Best Overall: ProCaps White Mulberry Leaf with Cinnamon – dual-action blood sugar support
- Best Value: Pure Encapsulations Mulberry Leaf Extract – pharmaceutical-grade quality
- Best Standardized: Nature’s Way White Mulberry – consistent DNJ content
Quick Comparison
| Product | Key Ingredients | Form | Servings | Best For |
|---|---|---|---|---|
| Ultimate Berberine Phytosome | Berberine 500mg, Mulberry extract | Capsules | 60 | Metabolic health |
| Zazzee Gymnema Extract | Gymnema 7500mg, Mulberry leaf | Capsules | 120 | Sugar cravings |
| Thorne Berberine | Berberine 500mg | Capsules | 60 | Overall support |
| MD Process GlucoBerry | Maqui berry, Gymnema, Chromium | Capsules | 30 | Kidney support |
| 1MD Nutrition Blood Sugar | Cinnamon, Chromium, Berberine, Neem | Capsules | 60 | Comprehensive formula |
| Toniiq Dihydroberberine | Dihydroberberine 1000mg, Ceylon cinnamon | Capsules | 60 | Enhanced absorption |
| Biotics Research Bio-HPF | DGL, Licorice, Berberine, Slippery elm | Capsules | 90 | Digestive support |
1. Ultimate Berberine Phytosome – Best Overall
- In each 1,000 mg serving, Ultimate Berberine has 𝟱𝟱𝟬 𝗺𝗴 𝗼𝗳 𝗕𝗲𝗿𝗯𝗲𝗿𝗶𝗻𝗲 𝗣𝗵𝘆𝘁𝗼𝘀𝗼𝗺𝗲 for Optimal Absorption and 𝟰𝟱𝟬 𝗺𝗴 𝗼𝗳 𝗕𝗲𝗿𝗯𝗲𝗿𝗶𝗻𝗲 𝗛𝗖𝗟 for additional support.
- 𝗕𝗲𝗿𝗯𝗲𝗿𝗶𝗻𝗲 𝗣𝗵𝘆𝘁𝗼𝘀𝗼𝗺𝗲 𝗶𝘀 𝗮 𝗰𝗼𝗺𝗽𝗼𝘂𝗻𝗱 𝗲𝘅𝘁𝗿𝗮𝗰𝘁𝗲𝗱 𝗳𝗿𝗼𝗺 𝗜𝗻𝗱𝗶𝗮𝗻 𝗯𝗮𝗿𝗯𝗲𝗿𝗿𝘆. It provides free-radical fighting activity, 𝗶𝗺𝗺𝘂𝗻𝗲 𝘀𝘆𝘀𝘁𝗲𝗺 𝘀𝘂𝗽𝗽𝗼𝗿𝘁, and 𝗽𝗿𝗼𝗽𝗲𝗿 𝗺𝗶𝗰𝗿𝗼𝗯𝗶𝗼𝗺𝗲 𝗯𝗮𝗹𝗮𝗻𝗰𝗲. 𝗜𝘁 𝗵𝗲𝗹𝗽𝘀 𝗮𝗰𝘁𝗶𝘃𝗮𝘁𝗲 𝗔𝗠𝗣𝗞, also known as the body's metabolic master switch. Ultimate Berberine with Berberine Phytosome and Berberine HCL 𝗵𝗲𝗹𝗽𝘀 𝘀𝘂𝗽𝗽𝗼𝗿𝘁 𝗴𝗮𝘀𝘁𝗿𝗼𝗶𝗻𝘁𝗲𝘀𝘁𝗶𝗻𝗮𝗹 𝗵𝗲𝗮𝗹𝘁𝗵, 𝗰𝗵𝗼𝗹𝗲𝘀𝘁𝗲𝗿𝗼𝗹, 𝗮𝗻𝗱 𝗹𝗶𝗽𝗶𝗱 𝗹𝗲𝘃𝗲𝗹𝘀 within normal ranges*
- 𝗩𝗲𝗴𝗮𝗻, 𝗡𝗼𝗻-𝗚𝗠𝗢, 𝗚𝗹𝘂𝘁𝗲𝗻-𝗳𝗿𝗲𝗲 - Our Doctor formulated Berberine with is made with 100% Natural, Vegan, Non-GMO, Gluten-free ingredients. Our capsules contain NO Fillers, Soy, Preservatives, Binders, or chemicals.
- 𝗧𝗲𝘀𝘁𝗲𝗱 & 𝗧𝗿𝘂𝘀𝘁𝗲𝗱 𝗜𝗻𝗴𝗿𝗲𝗱𝗶𝗲𝗻𝘁𝘀 - Our non-GMO, soy-free, gluten-free and dairy-free, berberine capsules supplements is formulated in the USA, in a registered, approved, inspected state-of-the-art facility, with strict adherence to Good Manufacturing Practices (GMP). Each and Every batch is 3rd Party Tested for Quality, Purity, Potency and Contamination.
- 𝗧𝗿𝘂𝘀𝘁𝗲𝗱 𝗕𝗿𝗮𝗻𝗱 - Satisfaction Assured - If our Berberine supplement pills do not bring noticeable value to you and you don't absolutely love them, your purchase is on us. No Questions Asked. Our world-class customer service wants you to be satisfied with your purchase. Absolutely no risk. The bottle comes with a Money-Back Guarantee.
This advanced formula combines berberine phytosome with mulberry leaf extract for superior absorption and metabolic support.
The phytosome technology enhances berberine’s bioavailability by up to 9.6 times compared to standard berberine. You’ll get 500mg of highly absorbable berberine plus supporting botanicals including mulberry leaf extract that work synergistically to support healthy glucose metabolism. The formula is specifically designed for those over 35 looking to maintain optimal metabolic health.
What We Like
- Enhanced absorption with phytosome technology
- Dual-action formula with mulberry extract
- Clinical dose of berberine
- Third-party tested for purity
What Could Be Better
- Premium price point
- Requires 2 capsules daily
Bottom Line: Best choice for maximum effectiveness and absorption in a comprehensive blood sugar support formula.
2. Zazzee Gymnema Sylvestre Extract – Best for Sugar Cravings
- OUTSTANDING VALUE: Our Extra Strength Gymnema Sylvestre Extract contains 7500 mg strength per serving, is made from a potent 25:1 extract AND contains 120 capsules per bottle – an amazing value! Compare this to other leading brands that contain less than 120 capsules, use a much less potent, non-extract powder, and do not contain 25% Gymnemic Acid. Our Extra Strength Gymnema Sylvestre Extract is a bargain not be found elsewhere!
- 7500 MG STRENGTH, 25% GYMNEMIC ACID: Each serving contains 7500 mg strength of Gymnema Sylvestre Extract made from a potent, powerful 25:1 extract. Combine that with a minimum of 25% Gymnemic Acid, and our Extra Strength Gymnema Sylvestre Extract is one of the strongest dosages available!
- ORGANIC GYMNEMA SYLVESTRE: Any Gymnema Sylvestre that is not organic can be contaminated and toxic to your body. With Zazzee Naturals Organic Gymnema Sylvestre Extract, you can be sure your Gymnema Sylvestre is organic, all-natural, vegan, and non-GMO.
- NATURAL, VEGAN, & NON-GMO: All ingredients, including the capsule, are 100% vegan. Our Extra Strength Gymnema Sylvestre Extract does not contain any sweeteners, artificial flavors, wheat, corn, gluten, soy, milk, egg, fish, shellfish, or tree nut ingredients. Enjoy the amazing benefits of our potent Gymnema Sylvestre Extract without worrying about what else might be hiding in each capsule!
- GOLD STANDARD PRODUCTION: Your health and safety mean everything to us. For that reason, our Extra Strength Gymnema Sylvestre Extract is manufactured in the USA, in a fully certified facility with adherence to good manufacturing policies and under the most stringent quality control. You can rest assured that you get the best value for your money!
This organic gymnema extract delivers impressive 7500mg strength to help curb sugar cravings naturally.
Standardized to 25% gymnemic acid, this formula provides powerful support for healthy glucose levels while helping reduce your desire for sweets. The 25:1 extract concentration means you’re getting the equivalent of 7500mg of gymnema from just 300mg per serving. It’s certified organic, vegan, and contains no fillers or additives.
What We Like
- High-potency 25:1 extract ratio
- Standardized for consistent gymnemic acid content
- USDA certified organic
- 4-month supply in one bottle
What Could Be Better
- Focuses primarily on gymnema rather than mulberry
- May affect taste perception temporarily
Bottom Line: Excellent option for those specifically looking to manage sugar cravings alongside blood sugar support.
3. Thorne Berberine – Best Premium Formula
- CARDIOVASCULAR SUPPORT: Berberine may support cardiovascular function
- AMPK ACTIVATOR: Berberine is a powerful AMPK Activator that supports antioxidant activity and metabolic function
- TWO MONTH SUPPLY: Double Wood's Berberine contains 60 convenient single dose capsules, each with 500mg. Unlike competitors, we offer a convenient single capsule serving
- ROOTED IN QUALITY: Manufactured and Tested in the USA from Globally Sourced Ingredients. Double Wood's Berberine is manufactured and tested for microbes and heavy metals right here in the USA from Globally Sourced Ingredients. Plus, it is Vegetarian safe, Non-GMO and gluten-free
- WE BOTTLE WELLNESS: At Double Wood we provide pure, potent supplements that deliver exceptional value, all backed by careful sourcing and rigorous third-party testing
Thorne’s pharmaceutical-grade berberine provides pure, potent support for AMPK activation and metabolic health.
This NSF Certified for Sport formula delivers 500mg of pure berberine HCl in each capsule, supporting healthy blood sugar metabolism through AMPK activation. Thorne’s rigorous testing ensures you’re getting exactly what’s on the label with no hidden ingredients. The formula is vegan, gluten-free, and manufactured to pharmaceutical standards.
What We Like
- NSF Certified for Sport quality
- Pure berberine with no fillers
- Pharmaceutical-grade manufacturing
- Third-party tested for purity
What Could Be Better
- Higher price per serving
- Single-ingredient formula
Bottom Line: The gold standard for those who prioritize quality and purity in their supplements.
4. MD Process GlucoBerry – Best Multi-Ingredient
- Support Optimal Blood Health: GlucoBerry supplement is loaded with powerful antioxidant support from our custom blend of Maqui Berry, Biotin, Gymnema leaf extract, and Chromium.
- Superstar Kidney Support: GlucoBerry contains optimized maqui berry, a superfood known to support optimal kidney function, especially in effectively draining excess substances from your blood. This helps maintain balanced levels throughout the day.
- Doctor-Formulated: Dr. Mark Weis and his team designed this blend for maximum health support, based on real-world results. Just take one small capsule each day. Manufactured in the USA. Vegetarian and vegan-friendly. Rigorously tested for purity and effectiveness.
- Easy to Take: Developed in its most bioavailable form, GlucoBerry comes with 30 capsules to give you enough support for the entire month. It only takes one easy-to-swallow GluoBerry capsule each day, best taken in the morning after meal.
- Your Path to Confidence: At MD Process, we believe that everyone deserves to feel great about their health and themselves. Through years of experience, we've honed our formula development process with industry-leading knowledge, hours of research, technical expertise, and compassion for our customers.
This doctor-formulated blend combines maqui berry, gymnema, chromium, and biotin for comprehensive blood sugar support.
GlucoBerry focuses on supporting kidney function’s role in blood sugar management, featuring optimized maqui berry extract rich in delphinidins. The formula also includes gymnema leaf extract and chromium picolinate to support healthy glucose metabolism from multiple angles. It’s designed to help maintain balanced blood sugar levels throughout the day.
What We Like
- Unique kidney-focused approach
- Doctor-formulated blend
- Rich in antioxidant delphinidins
- One capsule daily convenience
What Could Be Better
- 30-day supply at higher price
- Proprietary blend amounts not disclosed
Bottom Line: Innovative formula for those seeking a comprehensive approach to blood sugar management.
5. 1MD Nutrition Blood Sugar Support – Best Comprehensive
- Contains 7 carefully-selected ingredients, including berberine bark extract, chromium, and gymnema.
- 100% Vegan & Comprehensive Ingredients: Perfect for any dietary restrictions, it contains the patented Cinsulin, a cinnamon extract that utilizes the beneficial properties of cinnamon.
- GlucoseMD is formulated to offer targeted immune system support.*
- GlucoseMD is formulated to offer targeted immune system support.*
This physician-formulated blend brings together cinnamon bark, chromium, neem leaf, berberine, and cayenne pepper for robust metabolic support.
The formula features 10:1 cinnamon bark water extract for enhanced potency, combined with berberine and chromium to support healthy insulin function. Neem leaf and cayenne pepper round out the formula with additional metabolic benefits. All ingredients are carefully selected to work synergistically for optimal blood sugar balance.
What We Like
- Five proven ingredients in clinical doses
- Enhanced absorption with water extracts
- Physician-formulated
- Non-GMO and gluten-free
What Could Be Better
- Requires 2 capsules per serving
- Contains cayenne which may not suit sensitive stomachs
Bottom Line: Well-rounded formula for comprehensive blood sugar and metabolic support.
6. Toniiq Dihydroberberine Supplement – Best Absorption
- Largest Serving Size 1,000mg Formula: Our dihydroberberine supplement provides the largest serving size on the market, with 200 mg of GlucoVantage Dihydroberberine per serving.
- Enhanced Bioavailability: Dihydroberberine has been shown in studies to have significantly higher bioavailability and potency compared to regular Berberine. Our GlucoVantage Dihydroberberine is designed to be 5X more effective than regular Berberine, ensuring maximum absorption and potency.
- Superior Extracts for Enhanced Benefits: We deliver 400 mg of Ceylon Cinnamon extract per serving and 400 mg of Milk Thistle extract with a 50:1 extract ratio, ensuring superior quality and potency. These ingredients support cardiovascular health, liver function, and overall well-being.
- Setting a New Standard for Purity: To ensure that you are getting the highest-quality product, each batch is tested for quality and purity both during and after manufacturing. Toniiq products are produced in a GMP-certified, state-of-the-art manufacturing facility right here in the USA.
- Each Batch is Individually Tested: We test each batch both ourselves and through a third-party independent laboratory to ensure your Toniiq product contains the correct standardized level of purity and active ingredients. We also test each batch for any possible additives, contaminants, and impurities.
This ultra-high potency formula provides 1000mg of dihydroberberine with Ceylon cinnamon for maximum bioavailability.
Dihydroberberine is the active metabolite of berberine, offering up to 5 times better absorption than standard berberine supplements. The GlucoVantage form ensures you get more benefit from each dose. Combined with 10:1 Ceylon cinnamon extract, this formula delivers powerful support for healthy glucose metabolism in just one capsule daily.
What We Like
- Superior absorption compared to regular berberine
- High potency 1000mg formula
- Premium Ceylon cinnamon included
- Once-daily dosing
What Could Be Better
- Higher cost per bottle
- Some may prefer traditional berberine
Bottom Line: Top choice for maximum absorption and convenience in a single daily capsule.
7. Biotics Research Bio-HPF – Best for Digestive Support
- FOSTER MICROBIAL BALANCE: This blend of botanical extracts help support a healthy gastric microbial balance and stomach mucosa lining; Bismuth citrate, barberry and berberine, in particular, help promote good bacteria
- SOOTHING TO THE STOMACH: Microbial imbalance or an unhealthy diet may cause a burning or bloating sensation in the stomach; DGL, deglycyrrhizinated licorice, is known for its healing effects of the gastric mucosa; It helps coat and soothe the area, and may be helpful in times of gastric upset
- SUPPORTS GASTROINTESTINAL HEALTH: The natural herbal ingredients found in Bio-HPF promote the healing and cleansing of the entire gastrointestinal tract, which aids in healthy digestive function
- WHO WE ARE: We have revolutionized the nutritional supplement industry by combining “The Best of Science and Nature"; Our focus on research, natural effectiveness, product safety, efficacy, quality control, and ongoing innovation drives our advancements in the field
- QUALITY MADE IN THE USA: We produce tablets, capsules, powders, and liquids in a Texas Department of Health licensed, GMP-certified production and ISO-certified laboratory facility; All products are tested in a state-of-the-art laboratory to ensure safety, efficacy, and purity, and are Gluten Free!
This unique formula combines berberine with gut-supportive herbs like DGL, licorice, and slippery elm for comprehensive digestive and metabolic wellness.
Bio-HPF takes a holistic approach by supporting both gastric health and glucose metabolism. The deglycyrrhizinated licorice (DGL) and slippery elm soothe digestive tissues while berberine supports healthy blood sugar levels. This makes it ideal for those dealing with both metabolic and digestive concerns.
What We Like
- Dual-action digestive and metabolic support
- Soothing herbs for gastric comfort
- Professional-grade formulation
- 90-capsule bottle for extended use
What Could Be Better
- More focused on digestive health than blood sugar alone
- Requires multiple capsules per day
Bottom Line: Excellent choice for those seeking both digestive comfort and blood sugar support in one formula.
How to Choose the Best Mulberry Leaf Supplement
When selecting a mulberry leaf supplement, standardization is key. Look for products that specify the concentration of DNJ (1-deoxynojirimycin), the active compound responsible for mulberry leaf’s blood sugar benefits. A 5% DNJ content is considered effective, though some premium formulas may offer higher concentrations.
Consider whether you want pure mulberry leaf or a combination formula. While standalone mulberry products provide focused support, many people benefit from combinations with cinnamon, chromium, or berberine. These complementary ingredients work through different mechanisms to support healthy glucose metabolism, potentially offering more comprehensive benefits than mulberry alone.
Pay attention to dosing convenience and your personal preferences. Some formulas require just one capsule daily, while others need multiple doses throughout the day. If you’re taking the supplement with meals to support post-meal blood sugar levels, you’ll want a product designed for that timing. Also check whether the product is vegan, gluten-free, or organic if those factors matter to you.
Quality matters significantly with herbal supplements. Choose products from reputable manufacturers who conduct third-party testing and clearly label their ingredients. Look for certifications like NSF, USP, or cGMP that indicate adherence to quality standards. Avoid products with excessive fillers, artificial ingredients, or proprietary blends that don’t disclose specific amounts of active ingredients.
Benefits of Mulberry Leaf Supplements
Mulberry leaf’s primary benefit comes from its ability to inhibit alpha-glucosidase enzymes in your digestive system. These enzymes break down complex carbohydrates into simple sugars, so by temporarily slowing this process, mulberry leaf helps moderate the spike in blood sugar that typically follows a carbohydrate-rich meal. This makes it particularly useful when taken before meals containing significant amounts of carbs or sugars.
Beyond blood sugar management, mulberry leaf provides powerful antioxidant support through its flavonoid and polyphenol content. These compounds help protect your cells from oxidative stress and may support cardiovascular health. Some research suggests that mulberry leaf’s antioxidants can help maintain healthy cholesterol levels already in the normal range, contributing to overall metabolic wellness.
The DNJ compound in mulberry leaf may also help reduce sugar cravings over time by affecting how your taste buds perceive sweetness. Regular supplementation might make overly sweet foods less appealing, potentially supporting healthier eating habits. Additionally, mulberry leaf has been traditionally used to support liver function and promote overall metabolic health, though more research is needed to fully understand these effects.
Frequently Asked Questions
When should I take mulberry leaf supplements?
For optimal results, take mulberry leaf supplements immediately before meals that contain carbohydrates or sugars. The active compounds work by slowing carbohydrate digestion, so timing is crucial. Most people take one dose before their largest meals of the day, though some formulas are designed for use with each meal. Follow the specific timing instructions on your chosen product for best results.
How long does it take for mulberry leaf to work?
Mulberry leaf’s effects on post-meal blood sugar happen relatively quickly, within 1-2 hours of taking it with a meal. However, you may notice broader benefits to your overall blood sugar patterns and reduced sugar cravings after 4-8 weeks of consistent use. Keep in mind that supplements work best as part of a healthy lifestyle that includes balanced nutrition and regular physical activity.
Can I take mulberry leaf with diabetes medication?
If you’re currently taking diabetes medication or insulin, consult your healthcare provider before adding mulberry leaf supplements. While the combination can be beneficial, it may enhance the blood sugar-lowering effects of your medications, potentially requiring dosage adjustments. Your doctor can help you monitor your levels and modify your treatment plan as needed to avoid hypoglycemia.
What’s the difference between mulberry leaf and mulberry fruit?
Mulberry leaves and fruits have different nutritional profiles and benefits. The leaves contain higher concentrations of DNJ and other compounds that support healthy blood sugar metabolism, making them the preferred choice for glucose management. Mulberry fruits, while nutritious and antioxidant-rich, don’t provide the same level of blood sugar support. For metabolic health, choose products specifically made from mulberry leaves rather than fruit extracts.
Are there any side effects of mulberry leaf supplements?
Mulberry leaf is generally well-tolerated with minimal side effects for most people. Some individuals may experience mild digestive upset, bloating, or loose stools when first starting supplementation, particularly at higher doses. These effects typically resolve as your body adjusts. Start with a lower dose and gradually increase to assess your tolerance. If you experience persistent discomfort, reduce the dosage or discontinue use.
How much mulberry leaf extract should I take daily?
Effective doses typically range from 1000-3000mg of mulberry leaf per day, or 50-150mg of standardized DNJ extract. The exact amount depends on the product’s concentration and your individual needs. Most clinical studies use doses in this range taken before meals. Always start with the manufacturer’s recommended serving size and adjust based on your response and healthcare provider’s guidance.
Can mulberry leaf help with weight management?
While mulberry leaf isn’t primarily a weight loss supplement, supporting healthy blood sugar levels can indirectly benefit weight management efforts. By moderating post-meal glucose spikes and potentially reducing sugar cravings, mulberry leaf may make it easier to maintain a balanced diet and avoid excess calorie consumption. However, it’s most effective when combined with overall healthy eating habits and regular exercise rather than used as a standalone weight loss solution.
Is white mulberry different from other mulberry varieties?
White mulberry (Morus alba) is the most commonly used variety in blood sugar supplements because it contains the highest concentrations of beneficial compounds like DNJ. While red and black mulberry varieties also offer health benefits, white mulberry has been more extensively studied for glucose management. When choosing a supplement, look specifically for white mulberry leaf extract if blood sugar support is your primary goal.
