Best Supplements for Lyme Disease (2026) – Top 10 Reviewed
Lyme disease and its co-infections create complex immune challenges that can persist long after initial treatment. Supporting your immune system with targeted supplements can help manage symptoms, reduce inflammation, and support recovery from both acute and chronic Lyme. This guide reviews the most effective supplements for strengthening immunity and managing the inflammatory responses associated with Lyme disease.
Our Top Picks at a Glance
- Best Overall: Super Antioxidants Supplement — comprehensive immune and antioxidant support
- Best Adaptogen: Genius Mushrooms — immune modulation and resilience
- Best Vitamin D: NATURELO Vitamin D3 — essential immune regulation
Quick Comparison
| Product | Key Ingredients | Form | Servings | Best For |
|---|---|---|---|---|
| Super Antioxidants Supplement | Elderberry, Herbs, Fruits | Capsules | 60 | Immune support |
| Genius Mushrooms | Reishi, Cordyceps, Lion’s Mane | Capsules | 90 | Adaptogenic support |
| NATURELO Vitamin D3 | D3 5000 IU from Lichen | Capsules | 180 | Immune function |
| Metagenics Zinc A.G. | Zinc Bisglycinate | Capsules | 180 | Immune defense |
| EZ Melts Vitamin C | Vitamin C 1000mg | Melts | 60 | Antioxidant |
| Lymphatic Drainage Supplement | Echinacea, Astragalus | Capsules | 60 | Detoxification |
| PurePremium Kidney Support | Astragalus, Herbs | Capsules | 60 | Detox support |
| Olive Leaf Extract | Olive Leaf 750mg | Capsules | 120 | Antimicrobial |
1. Super Antioxidants Supplement with Elderberry — Best Overall
- Maintain Health With Full Body Antioxidant Support: Crucial to good health, antioxidants help support a strong and healthy immune system. Loaded with superfood extracts like Pomegranate, this supplement boosts energy, supports the immune system, and supports general wellbeing.
- Super Antioxidants For Radiant Skin: As the body’s largest organ, your skin needs some special TLC! With Acai Berry and Vitamin E, our supplement helps promote healthy, radiant skin!
- Natural Antioxidants Supplement: We’re able to offer unmatched results because we utilize a blend of natural extracts and vitamins! With Goji Berry and Vitamins A and C, our supplement delivers incredible effectiveness that your body will thank you for!
- Premium Quality: As with all Healths Harmony supplements, our Antioxidant Blend is American-made, using global ingredients, under strict GMP guidelines. With naturally potent ingredients like Trans Resveratrol and Hawaiian Noni, you’d be hard pressed to find anything better!
- Add To Cart Today: Try a full bottle of Healths Harmony Super Antioxidants, and feel the benefits of this premium supplement for yourself; click add to cart today!
High-potency antioxidant blend provides comprehensive immune support while combating the oxidative stress and inflammation characteristic of Lyme disease.
Lyme disease and co-infections generate significant oxidative stress that damages tissues and impairs immune function. This powerful formula delivers elderberry for immune support, resveratrol for anti-inflammatory benefits, and additional antioxidants that protect cells from oxidative damage. The comprehensive blend supports your body’s ability to fight persistent infections while reducing the inflammatory responses that cause many Lyme symptoms.
What We Like
- Potent antioxidants combat oxidative stress from chronic infection
- Elderberry supports immune function against bacterial infections
- Multi-faceted approach addresses inflammation and immune support
What Could Be Better
- Multiple ingredients require monitoring for individual tolerance
- Benefits build gradually over several weeks
Bottom Line: A comprehensive antioxidant formula that supports immune function and reduces oxidative damage in Lyme disease.
2. Genius Mushrooms — Best Immune Modulation
- Nurture: Genius Mushrooms by The Genius Brand combines 3 of the most researched mycological species on the planet that help enhance clarity, system support function, and more. Genius Mushrooms are keto, paleo, and vegan friendly. Serving size - 3 capsules, 30 servings per container
- System Booster: Step up your support with Reishi Mushroom Extract. Used for centuries, this booster is what you need to help keep yourself in check and dodge common ailments
- Caffeine-Free Energy: Lion’s Mane provides boosting benefits to support focus, function, and mood. Cordyceps helps elevate your energy levels via ATP (natural energy) production, allowing for increased oxygen utilization and athletic endurance
- How to Use: Take 3 capsules with 8 oz of water 20 minutes before a meal once a day. You may also take 1 capsule three times daily before meals, if preferred
- Supplement Smarter: Genius Brand supplements are a rejection of backwards industry dogma that misled generations of enthusiasts. For us, innovation and science-backed ingredients come first. Whether you’re a pro athlete, stay-at-home parent, retiree, or anything in between, our products can be of benefit to you. We’re all humans, and we are in this together
Plant-based medicinal mushroom blend provides immune-modulating support, stress adaptation, and energy enhancement for Lyme recovery.
Medicinal mushrooms offer unique benefits for Lyme disease through their immune-modulating beta-glucans and adaptogenic properties. Reishi helps balance immune responses to prevent both inadequate and excessive reactions. Cordyceps supports energy production and oxygen utilization, addressing the profound fatigue common in Lyme. Lion’s mane supports nervous system health, which can be affected by neuroborreliosis. Together, these mushrooms help your body mount appropriate immune responses while building resilience.
What We Like
- Immune-modulating beta-glucans support balanced responses
- Cordyceps addresses Lyme-related fatigue naturally
- Lion’s mane supports nervous system health and cognition
What Could Be Better
- Full benefits require consistent long-term use
- Some may need gradual introduction to avoid reactions
Bottom Line: A powerful mushroom blend that supports immune balance, energy, and nervous system health in Lyme disease.
3. NATURELO Vitamin D3 5000 IU — Best Immune Regulation
- PLANT-BASED VITAMIN D3: Most vitamin D3 supplements are made from lanolin secreted from sheep skin. Our Vegan Vitamin D3 is sustainably sourced from wild-harvested lichen with no animal byproducts of any kind.
- HIGH POTENCY: 5000 IU of naturally bioactive Vitamin D3 can help restore blood levels in those who are deficient. Studies show that nearly half the U.S. population may be deficient in Vitamin D.*
- ESSENTIAL IMMUNE SUPPORT: Vitamin D is crucial for maintaining a healthy immune system.* Vitamin D levels may be especially low in winter or when you are stuck indoors.
- SUPPORTS BONE HEALTH: Vitamin D is necessary for your body to absorb calcium for strong bones and teeth. Risk of bone loss increases with age, particularly for women, and is also a risk during pregnancy.*
- CLEAN LABEL: Made in a GMP compliant facility. Non GMO, vegetarian, vegan, and gluten free. Does NOT contain soy, dairy, yeast, eggs, nuts, caffeine, preservatives, or coloring.
Plant-based vitamin D3 delivers 5000 IU to optimize immune cell function critical for fighting Borrelia and co-infections.
Vitamin D is essential for proper immune function, regulating both innate and adaptive immune responses needed to combat Lyme disease. Deficiency is common in Lyme patients and impairs the ability to clear infections effectively. The 5000 IU dose efficiently corrects deficiency, supporting T-cell function, antimicrobial peptide production, and inflammatory regulation. Plant-based D3 from lichen provides the active form in a vegan-friendly formula.
What We Like
- Therapeutic dose optimizes immune cell function
- Essential for T-cell responses against Borrelia
- Plant-based formula suitable for all diets
What Could Be Better
- Requires months for full deficiency correction
- Should be taken with fat for optimal absorption
Bottom Line: An essential immune-supporting vitamin that optimizes your body’s ability to fight Lyme disease infections.
4. Metagenics Zinc A.G. — Best Mineral Support
- Superior Absorption: Provides zinc bound to arginine and glycine (amino acid chelates) for high absorption and gentle GI tolerance*
- Immune & Antioxidant Support: Essential for immune defense and antioxidant activity, helping protect cells from oxidative stress*
- Bone, Skin & Energy Metabolism: Supports bone health, tissue repair, healthy skin, and energy metabolism through zinc's role in over 300 enzymatic reactions*
- Clean and Trusted Formula: Non-GMO and gluten-free. Manufactured in GMP-certified facilities with third-party testing for purity and potency*
- As the #1 Doctor Recommended Professional Supplement Brand, Metagenics delivers clinically proven, precision-crafted formulas to support your health at its core‚ because true wellness starts with integrity, balance, and expertise
Highly absorbable zinc bisglycinate supports immune cell function and helps combat the bacterial infections in Lyme disease.
Zinc is crucial for proper immune system function, particularly for fighting bacterial infections like Borrelia burgdorferi. It supports T-cell development, natural killer cell activity, and the production of antimicrobial proteins. This professional-grade formula uses zinc bisglycinate for superior absorption without stomach upset, enhanced further by arginine and glycine chelation. The gentle formulation is important for those with digestive sensitivity from Lyme disease.
What We Like
- Superior absorption supports optimal immune function
- Essential for T-cell and NK cell activity against infection
- Gentle on sensitive digestive systems
What Could Be Better
- Higher cost than basic zinc supplements
- Large bottle may be excessive for some users
Bottom Line: A high-quality zinc supplement that supports the immune defenses needed to fight Lyme disease.
5. EZ Melts Vitamin C — Best Antioxidant
- Vitamin C Supplement: EZ Melts Vitamin C is formulated to dissolve quickly in your mouth, so keeping up with your health is easy and convenient
- Immune & Antioxidant Support: Formulated to provide antioxidant protection and immune support while supporting healthy energy levels*
- Overall Wellness & Skin Support: Vitamin C helps support collagen production, protect cells from oxidative stress, and support healthy skin and vitality*
- Daily Vitamin C Tablets: As a dietary supplement, take two dissolvable vitamin C tablets a day or as recommended by your healthcare professional
- Non-GMO & Vegan Supplement: EZ Melts makes it easier to take superior quality vitamins—free from artificial flavors, gluten, dairy, soy, and sugar
Fast-dissolving vitamin C delivers 1000mg to support immune function, reduce inflammation, and combat oxidative stress from chronic infection.
Vitamin C is essential for immune cell function and acts as a powerful antioxidant protecting against the oxidative damage from chronic Lyme disease. It supports white blood cell production and function, enhances antimicrobial activity, and helps reduce inflammatory responses. The quick-dissolve format allows for flexible dosing throughout the day, which is beneficial since vitamin C is water-soluble and not stored long-term.
What We Like
- Convenient format allows multiple daily doses
- High 1000mg dose supports immune function
- Clean formula without triggering additives
What Could Be Better
- Requires several doses daily for sustained levels
- Some may prefer capsule over dissolving tablet
Bottom Line: A versatile vitamin C supplement that supports immune function and antioxidant protection in Lyme disease.
6. Lymphatic Drainage Supplement — Best Detox Support
- Don’t Be Fooled! Many lymphatic drainage supplements use ineffective herbs and questionable ingredients like maltitol that may cause bloating & gas. At Peak Performance, we carefully selected 7 natural ingredients traditionally known to *naturally* improve the lymphatic system. Great for men and women.
- Lymph System Support – Featuring Echinacea, Red Clover, Burdock Root & more, this formula supports healthy lymphatic function and immune balance.*
- This supplement is safe for long-term use and well-tolerated. It may be taken with other supplements, but consult your doctor if needed. Ideal for busy professionals, parents, and athletes.
- Vegan Friendly & Free of Soy, Milk, Egg, Shellfish, Corn, Wheat & Peanuts. Contains NO Gluten or Preservatives. Manufactured Under The Highest Quality GMP Regulations and USA Standards.
- 1-For-1 Donation Match Program! Through our 1-for-1 partnership with the nonprofit Vitamin Angels, every purchase provides a child at risk of malnutrition with vitamins for a full year. To date we have helped over 3 million children through this partnership, so thank you for supporting this mission.
Seven-ingredient formula supports lymphatic drainage to help clear toxins, inflammatory compounds, and microbial debris from Lyme treatment.
Effective lymphatic drainage is crucial during Lyme treatment to help eliminate toxins released as bacteria die off. This comprehensive blend includes echinacea and astragalus for immune support, along with herbs that enhance lymphatic flow and detoxification. Supporting your body’s natural cleansing systems can reduce herxheimer reactions and help clear inflammatory compounds contributing to symptoms.
What We Like
- Supports clearance of toxins from bacterial die-off
- Echinacea and astragalus provide immune support
- Helps reduce herxheimer reaction severity
What Could Be Better
- Multiple ingredients may complicate identifying sensitivities
- Effects develop gradually over several weeks
Bottom Line: Valuable detoxification support for clearing toxins and reducing reactions during Lyme treatment.
7. PurePremium Kidney Support with Astragalus — Best Cleansing Support
- 3-IN-1 HEALTH SUPPORT: PurePremium kidney support supplement provides all-in-one solution for kidney cleanse detox & repair, urinary tract health, and bladder support — in just 1 cranberry supplement capsule daily.*
- ADVANCED CRANBERRY SUPPLEMENT: Our kidney health supplement offers a variety of nutrients for optimal kidney support. Each capsule includes cranberry powder, astragalus, ginger, turmeric, and grape seed extract supporting kidney flush and bladder heath.*
- 21 NATURAL INGREDIENTS: PurePremium kidney supplement combines 21 powerful ingredients, including nettle leaf, juniper berries, uva ursi, chanca piedra. Support your kidney detox effectively and simplify your health routine with our cranberry pills.*
- QUALITY & PURITY: Our commitment to excellence shines through in every aspect of our kidney health vitamins. Free from GMOs, gluten, and preservatives, our kidney supplements are meticulously crafted to ensure purity and provide you with a trusted choice for your wellness needs.*
- USA-MADE & LAB TESTED: PurePremium kidney vitamins are manufactured in a USA-based facility that complies with all cGMP standards. Additionally, each batch of our cranberry extract is tested by a third-party laboratory.*
Comprehensive kidney support formula with astragalus helps enhance detoxification and supports immune function during Lyme treatment.
Your kidneys work overtime during Lyme treatment to filter toxins, bacterial debris, and medication metabolites. This formula supports kidney function with astragalus, cranberry, and other herbs that enhance filtration and protect kidney tissue. Astragalus also provides immune-modulating benefits, helping balance immune responses against Borrelia while reducing inflammation.
What We Like
- Supports kidney function during antibiotic treatment
- Astragalus provides additional immune support
- Helps optimize toxin elimination
What Could Be Better
- Multiple herbs require monitoring for interactions
- Best used as part of comprehensive detox protocol
Bottom Line: Valuable kidney support that enhances detoxification and provides immune benefits during Lyme treatment.
8. Super Strength Olive Leaf Extract — Best Antimicrobial
- Pump Up The Positives: You’re probably already aware of the health benefits of olive oil, but it’s obviously unhealthy and impractical to ingest a bunch of oil. Now you can get those same advantages through the best non-GMO Olive Leaf capsule taken just once daily.
- Packed With Polyphenols: Our olive leaf capsules include 750mg of Olive Leaf Extract with 20% Oleuropein, the most potent component of olive bringing a myriad of health benefits. Responsibly sourced from non-GMO trees, our Olive Leaf Extract cleanly conveys the active ingredients with minimal processing.
- A Ton Of Benefits & Vegetarian: The olive has long been known as a health-giving tree. The leaves have a long history of traditional use. It’s a premium immune support supplement!
- Manufactured In The United States: We elect to manufacture at a cGMP certified facility, right here in the USA, using globally sourced ingredients. This means you can be confident that each capsule of our olive leaf supplement will contain only non-GMO vegetarian ingredients. Always consult your physician before taking this or any dietary supplement.
- Order Today: Try a full bottle of Healths Harmony Olive Leaf Extract, with 20% Oleuropein, and start reaping all the health benefits this amazing tree has to offer; click add to cart today!
High-potency olive leaf extract provides 750mg of natural antimicrobial compounds to support immune defenses against Borrelia and co-infections.
Olive leaf extract contains oleuropein and other compounds with broad-spectrum antimicrobial properties that support your immune system’s fight against Lyme bacteria. Research suggests olive leaf can help inhibit various pathogens including Borrelia and common co-infections. The 750mg potency provides therapeutic levels of active compounds, while the vegan, non-GMO formula ensures purity.
What We Like
- Natural antimicrobial properties support immune defenses
- High 750mg potency for therapeutic benefits
- May help with Borrelia and common co-infections
What Could Be Better
- Should be cycled rather than used continuously long-term
- Some may experience mild herxheimer reactions initially
Bottom Line: A potent natural antimicrobial that supports your immune system’s fight against Lyme disease infections.
How to Choose the Best Lyme Disease Supplements
Start with foundational immune support through vitamin D, vitamin C, and zinc. These nutrients are essential for proper immune cell function and are commonly deficient in Lyme patients. Vitamin D regulates immune responses, vitamin C supports white blood cell function, and zinc is crucial for T-cell development. Testing can identify specific deficiencies, though many practitioners recommend supplementing based on Lyme diagnosis alone.
Consider immune-modulating supplements that help balance responses rather than just boosting immunity. Lyme disease can trigger both inadequate responses allowing persistence and excessive responses causing inflammation. Medicinal mushrooms like reishi and herbs like astragalus help modulate immune function for more appropriate, effective responses against Borrelia.
Include antioxidant support to combat oxidative stress from chronic infection and treatment. Both the infection itself and antibiotic therapy generate significant free radicals that damage tissues. Vitamin C, vitamin E, and antioxidant-rich herbs help protect cells while supporting immune function and reducing inflammatory damage.
Add detoxification support if you’re undergoing antibiotic treatment or experiencing herxheimer reactions. Lymphatic drainage herbs, kidney support formulas, and binders help eliminate toxins released as bacteria die. This can reduce treatment side effects and symptom flares while supporting your body’s natural cleansing processes.
Choose antimicrobial herbs strategically and under professional guidance. Natural antimicrobials like olive leaf, cat’s claw, and Japanese knotweed can support immune defenses but should be used carefully to avoid overwhelming detox pathways. Work with a Lyme-literate practitioner to determine appropriate timing, dosing, and cycling of antimicrobial supplements.
Benefits of Lyme Disease Supplements
Properly chosen supplements enhance your immune system’s ability to fight Borrelia and co-infections. Vitamin D, zinc, and vitamin C optimize immune cell function, helping your body mount more effective responses against persistent bacteria. This immune support can improve treatment outcomes and potentially reduce recovery time.
Antioxidant supplements protect tissues from oxidative damage caused by chronic infection and treatment. Reducing oxidative stress helps preserve mitochondrial function, supports energy production, and may reduce long-term tissue damage. The antioxidant protection also helps manage inflammatory responses that contribute to symptoms.
Detoxification support helps manage herxheimer reactions and treatment side effects. Supplements that enhance lymphatic drainage and kidney function help your body eliminate bacterial toxins and medication metabolites more efficiently. This can make treatment more tolerable and reduce the severity of die-off reactions.
Immune-modulating supplements help prevent chronic inflammation while maintaining protective immunity. Balancing immune responses reduces tissue damage from excessive inflammation while ensuring adequate defenses against infection. This balanced approach may reduce symptom severity and support long-term recovery.
Frequently Asked Questions
Can supplements cure Lyme disease?
No, supplements cannot cure Lyme disease, especially in later stages requiring antibiotic treatment. However, supplements can significantly support immune function, reduce symptoms, enhance treatment effectiveness, and support recovery. Most Lyme-literate practitioners recommend supplements alongside antibiotics or other treatments as part of a comprehensive protocol, not as standalone therapy.
What supplements help with Lyme disease herxheimer reactions?
Detoxification supplements can help reduce herxheimer reactions. Lymphatic drainage herbs, binders like activated charcoal or bentonite clay, liver support formulas, and kidney support supplements all help eliminate toxins released during bacterial die-off. Vitamin C, glutathione, and antioxidants can also reduce oxidative stress from herxheimer reactions. Staying well-hydrated and supporting elimination pathways is crucial.
Should I take probiotics with Lyme disease antibiotics?
Yes, probiotics are important during antibiotic treatment for Lyme disease to prevent gut dysbiosis and maintain digestive health. Take probiotics at least 2-3 hours away from antibiotic doses to prevent them from being killed. Choose high-quality, multi-strain formulas with at least 50 billion CFU. Continue probiotics for several months after finishing antibiotics to restore healthy gut flora.
Can vitamin D help fight Lyme disease?
Yes, vitamin D is crucial for immune function against Lyme disease. It regulates T-cell responses, enhances antimicrobial peptide production, and modulates inflammatory responses. Many Lyme patients are deficient, and correction can improve immune responses against Borrelia. Optimal levels for Lyme treatment are typically 50-80 ng/mL, often requiring 5000-10,000 IU daily initially.
What natural antimicrobials help with Lyme disease?
Several natural antimicrobials show promise for Lyme support including olive leaf extract, Japanese knotweed (resveratrol), cat’s claw, andrographis, and garlic. These herbs have antimicrobial properties and immune-supporting benefits. However, they should be used under professional guidance, properly dosed, and cycled appropriately. They’re best used as complementary support rather than replacement for antibiotics in established Lyme disease.
How long should I take Lyme disease supplements?
Foundational immune support like vitamin D, vitamin C, and zinc should typically continue throughout treatment and recovery, often 6-12 months or longer. Detoxification support is most important during active treatment and can be reduced as symptoms improve. Antimicrobial herbs should be cycled under professional guidance rather than used continuously. Work with a Lyme-literate practitioner to develop an appropriate timeline for your specific situation.
Can supplements help with chronic Lyme disease?
Yes, supplements can be particularly important for chronic Lyme disease (post-treatment Lyme disease syndrome). Immune support, antioxidants, and anti-inflammatory supplements help manage persistent symptoms and support recovery. Many people with chronic Lyme benefit from ongoing immune modulation, mitochondrial support, and targeted symptom management through supplements alongside other therapies.
Should I avoid immune-boosting supplements with Lyme disease?
Not necessarily, but immune modulation is often better than simple immune boosting. Some Lyme patients have overactive immune responses causing inflammation, while others have inadequate responses allowing persistence. Immune-modulating supplements like medicinal mushrooms, vitamin D, and astragalus help balance responses rather than just stimulating them. Work with a practitioner to determine whether you need more immune support or better immune regulation.
