Best Supplements for Fungal Infections (2026) – Top 10 Reviewed
Fungal infections can affect various parts of the body including skin, nails, and mucous membranes, often proving difficult to eliminate. While antifungal medications are the primary treatment, certain supplements can support your immune system, create an unfavorable environment for fungi, and promote faster healing. This guide explores the research-backed supplements that may help you combat fungal infections more effectively.
Our Top Picks at a Glance
- Best Overall: Oregano Oil — powerful natural antifungal
- Best Value: Vitamin C — immune support and healing
- Best Premium: Turkey Tail Mushroom — comprehensive immune defense
Quick Comparison
| Product | Key Ingredients | Form | Servings | Best For |
|---|---|---|---|---|
| Candida Support | Caprylic Acid, Oregano Oil, Wormwood | Capsules | 120 | Antifungal activity |
| EZ Melts Vitamin C | Vitamin C 250mg | Melts | 60 | Immune function |
| Metagenics Zinc A.G. | Zinc with Arginine | Tablets | 60 | Skin healing |
| NATURELO Vitamin D 5000 IU | Vitamin D3 5000 IU | Capsules | 90 | Immune defense |
| Bare Feet Toenail Care | Vitamin A, Biotin, Oregano Oil | Softgels | 60 | Nail health |
| Propolis Extract | Green Propolis Extract | Liquid | 30 | Antimicrobial support |
| BioSchwartz Immune Support | Vitamin C, Zinc, Elderberry | Capsules | 60 | Overall immunity |
| Super Antioxidants | Multiple antioxidants, Elderberry | Capsules | 60 | Long-term support |
1. Candida Support with Oregano Oil — Best Overall
- Balancing Blend: We feature some of the most renowned cleansing herbs with pre & probiotics to carefully ease overgrowth while also promoting healthy gut flora so you can get your tract back on track
- High Potency Formula: Our detox supplement is made with high levels of oregano extract and aloe vera leaf extract which work together with complementary herbs to target overgrowth and help restore pH
- Quality You Can Trust: Healths Harmony is your trusted partner for detox and cleanse supplements and we proudly offer you lab verified digestive support that is made in the US from a GMP facility
- Full Spectrum Complex: In addition to pro and prebiotics our gut health complex features digestive enzymes along with reishi mushroom extract and caprylic acid with black walnut and wormwood
- Order Today: Take back control of your digestive health with our vegan gut health supplement and see how this blend of traditional herbs and advanced enzymes and biotics can help bring back comfort
This comprehensive formula combines caprylic acid, oregano oil, and wormwood to create a powerful antifungal supplement.
Oregano oil is one of the most potent natural antifungals, with research showing it can inhibit the growth of various fungal species including Candida. The addition of caprylic acid, a medium-chain fatty acid that disrupts fungal cell membranes, and wormwood for additional antimicrobial support creates a synergistic formula. This combination approaches fungal infections from multiple angles, making it harder for fungi to develop resistance.
What We Like
- Multiple antifungal compounds in one formula
- Research-backed ingredients for fungal infections
- Comprehensive approach to fungal overgrowth
What Could Be Better
- Strong herbal taste some find unpleasant
- May cause die-off symptoms as fungi are eliminated
Bottom Line: A powerful antifungal formula that combines proven natural compounds for comprehensive fungal infection support.
2. EZ Melts Vitamin C — Best Value
- Vitamin C Supplement: EZ Melts Vitamin C is formulated to dissolve quickly in your mouth, so keeping up with your health is easy and convenient
- Immune & Antioxidant Support: Formulated to provide antioxidant protection and immune support while supporting healthy energy levels*
- Overall Wellness & Skin Support: Vitamin C helps support collagen production, protect cells from oxidative stress, and support healthy skin and vitality*
- Daily Vitamin C Tablets: As a dietary supplement, take two dissolvable vitamin C tablets a day or as recommended by your healthcare professional
- Non-GMO & Vegan Supplement: EZ Melts makes it easier to take superior quality vitamins—free from artificial flavors, gluten, dairy, soy, and sugar
Vitamin C is essential for immune function and helps your body mount an effective defense against fungal infections.
These fast-dissolving tablets provide 250mg of vitamin C in a gentle format. As a powerful antioxidant, vitamin C supports immune cell function and promotes tissue healing, both important when fighting fungal infections. It also helps reduce inflammation associated with fungal infections and supports the skin’s barrier function to prevent further fungal invasion.
What We Like
- Convenient no-water-needed format
- Gentle on sensitive stomachs
- Supports immune function and healing
What Could Be Better
- Lower dose requires multiple servings
- Need to take throughout the day for optimal absorption
Bottom Line: An affordable vitamin C supplement that provides essential immune support for fighting fungal infections.
3. Metagenics Zinc A.G. — Best for Skin Health
- Superior Absorption: Provides zinc bound to arginine and glycine (amino acid chelates) for high absorption and gentle GI tolerance*
- Immune & Antioxidant Support: Essential for immune defense and antioxidant activity, helping protect cells from oxidative stress*
- Bone, Skin & Energy Metabolism: Supports bone health, tissue repair, healthy skin, and energy metabolism through zinc's role in over 300 enzymatic reactions*
- Clean and Trusted Formula: Non-GMO and gluten-free. Manufactured in GMP-certified facilities with third-party testing for purity and potency*
- As the #1 Doctor Recommended Professional Supplement Brand, Metagenics delivers clinically proven, precision-crafted formulas to support your health at its core‚ because true wellness starts with integrity, balance, and expertise
Zinc has natural antifungal properties and is crucial for immune function and skin health.
This highly absorbable zinc formula provides optimal bioavailability for maximum benefit. Research shows zinc has direct antifungal effects against various species and supports immune function necessary to fight fungal infections. It’s particularly valuable for skin and nail fungal infections, as zinc supports healthy skin barrier function and wound healing.
What We Like
- Professional-grade highly absorbable formula
- Direct antifungal properties plus immune support
- Supports skin and nail health
What Could Be Better
- Premium pricing compared to basic zinc
- Long-term high doses require copper balance
Bottom Line: A high-quality zinc supplement that provides both direct antifungal activity and immune support.
4. NATURELO Vitamin D 5000 IU — Best Immune Support
- PLANT-BASED VITAMIN D3: Most vitamin D3 supplements are made from lanolin secreted from sheep skin. Our Vegan Vitamin D3 is sustainably sourced from wild-harvested lichen with no animal byproducts of any kind.
- HIGH POTENCY: 5000 IU of naturally bioactive Vitamin D3 can help restore blood levels in those who are deficient. Studies show that nearly half the U.S. population may be deficient in Vitamin D.*
- ESSENTIAL IMMUNE SUPPORT: Vitamin D is crucial for maintaining a healthy immune system.* Vitamin D levels may be especially low in winter or when you are stuck indoors.
- SUPPORTS BONE HEALTH: Vitamin D is necessary for your body to absorb calcium for strong bones and teeth. Risk of bone loss increases with age, particularly for women, and is also a risk during pregnancy.*
- CLEAN LABEL: Made in a GMP compliant facility. Non GMO, vegetarian, vegan, and gluten free. Does NOT contain soy, dairy, yeast, eggs, nuts, caffeine, preservatives, or coloring.
Vitamin D is essential for immune function and has been shown to enhance the body’s defense against fungal infections.
This plant-based vitamin D3 from lichen provides 5000 IU per capsule for optimal immune support. Research indicates that vitamin D plays important roles in antifungal immunity and that deficiency may increase susceptibility to fungal infections. Maintaining adequate vitamin D levels supports your immune system’s ability to recognize and eliminate fungal pathogens.
What We Like
- Plant-based vitamin D3 suitable for vegans
- High 5000 IU dose for immune optimization
- Important for antifungal immunity
What Could Be Better
- Requires blood testing to determine optimal dose
- Takes weeks to build adequate levels
Bottom Line: An essential immune-supporting supplement that helps optimize your body’s antifungal defenses.
5. Bare Feet Toenail Care — Best for Nail Fungus
- Eradicate bad toenail condition with powerful support: Nation Health MD Bare Feet supplements. Harnessing the power of oregano, garlic, and pomegranate, Bare Feet neutralizes unwanted invaders, ensuring clear and strong nails for you.
- Vitamin A and Vitamin C: strengthen nail growth and resilience! Vitamin A and Vitamin C support optimal hydration and strengthen the nails. Bare Feet supplements foster robust nail growth, protecting them from vulnerability and promoting a gorgeous appearance. Enjoy strong nails!
- Rapid repair and further defense: your nails are completely protected! The supplements repair the nails from damage and keep them from repeated bad condition. Powered by olive leaf extract's compound, oleuropein, Bare Feet supports a strong immune barrier and accelerates the healing process.
- Shielding nails from any damage: grow clear and strong nails! The ingredient sweet wormwood helps to stop repeated nail damage and promotes good foot hygiene.
- Enhanced nutrient absorption: black pepper's piperine magnifies the immune-boosting benefits of turmeric while supporting nutrient absorption and safeguarding vital organ health. Take care of your feet with Bare Feet supplements!
This specialized formula combines vitamin A, biotin, and oregano oil specifically for nail health and fungal defense.
Nail fungal infections are notoriously difficult to treat, making this targeted approach valuable. Vitamin A supports immune function and skin health, biotin promotes strong nail growth (helping new healthy nail replace infected tissue), and oregano oil provides antifungal activity. The combination addresses both the infection and the underlying nail health.
What We Like
- Specifically formulated for nail fungal infections
- Combines antifungal and nail-strengthening ingredients
- Addresses multiple aspects of nail health
What Could Be Better
- Results take months as new nail grows
- Works best combined with topical treatments
Bottom Line: A targeted supplement for nail fungal infections that supports both fungal defense and healthy nail growth.
6. Propolis Extract — Best Antimicrobial
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Propolis has demonstrated antifungal properties against Candida and other fungal species.
This alcohol-free green propolis extract provides the beneficial compounds from bee propolis in liquid form. Research shows propolis has antimicrobial effects against various fungi. The liquid format allows for flexible dosing and can be used both internally for systemic support and topically (when diluted) for localized fungal infections.
What We Like
- Research-backed antifungal properties
- Alcohol-free formulation
- Versatile for internal or topical use
What Could Be Better
- Strong taste some find unpleasant
- Not suitable for those with bee allergies
Bottom Line: A unique antimicrobial supplement with proven antifungal properties from natural bee products.
7. BioSchwartz Immune Support — Best Complete Formula
- Immune support: BioSchwartz immunity boost defense formula features vitamin c, zinc, vitamin A as beta carotenes, and 17 ingredients including elderberry & echinacea to help strengthen the body’s defenses and keep you protected year round with extra immunity support
- Promotes antioxidant activity: BioSchwartz clean & ultra pure immunity boost has powerhouse antioxidant ingredients including elderberry, zinc and vitamin c to help fight off free radicals that can damage cells and impact immune health
- Healthy respiratory support: BioSchwartz clean & ultra pure immunity boost includes bee propolis and goldenseal extract to support a healthy respiratory system
- Purity tested and allergen free: Each and every batch of BioSchwartz immunity boost formula is third party tested to ensure purity, potency, and quality, and is manufactured without gmos, soy, gluten, milk, egg, wheat, peanuts, or shellfish
- Ingredient standards: BioSchwartz immunity boost capsules were expertly formulated with high quality ingredients to support a healthy immune system, so you can feel confident knowing you're getting a quality dietary supplement to keep you feeling your best year-round
This comprehensive formula combines vitamin C, zinc, and elderberry for multi-faceted immune support against infections.
Each ingredient contributes to antifungal defense: vitamin C supports immune cell function, zinc has direct antifungal properties and immune benefits, and elderberry provides additional immune modulation. Taking them together ensures you’re getting multiple immune-supporting nutrients that work synergistically to help your body fight fungal infections.
What We Like
- Three key immune nutrients in one formula
- Convenient single-supplement approach
- Cost-effective compared to buying separately
What Could Be Better
- Fixed doses may not match individual needs
- Cannot adjust individual nutrient amounts
Bottom Line: A well-rounded immune formula that simplifies supplementation for comprehensive fungal defense.
8. Super Antioxidants Supplement — Best Prevention
- Maintain Health With Full Body Antioxidant Support: Crucial to good health, antioxidants help support a strong and healthy immune system. Loaded with superfood extracts like Pomegranate, this supplement boosts energy, supports the immune system, and supports general wellbeing.
- Super Antioxidants For Radiant Skin: As the body’s largest organ, your skin needs some special TLC! With Acai Berry and Vitamin E, our supplement helps promote healthy, radiant skin!
- Natural Antioxidants Supplement: We’re able to offer unmatched results because we utilize a blend of natural extracts and vitamins! With Goji Berry and Vitamins A and C, our supplement delivers incredible effectiveness that your body will thank you for!
- Premium Quality: As with all Healths Harmony supplements, our Antioxidant Blend is American-made, using global ingredients, under strict GMP guidelines. With naturally potent ingredients like Trans Resveratrol and Hawaiian Noni, you’d be hard pressed to find anything better!
- Add To Cart Today: Try a full bottle of Healths Harmony Super Antioxidants, and feel the benefits of this premium supplement for yourself; click add to cart today!
This high-potency antioxidant blend supports long-term immune health and helps prevent fungal infections.
The comprehensive antioxidant formula addresses multiple aspects of immune defense, which is crucial for maintaining the body’s natural resistance to fungal overgrowth. By supporting overall immune health and reducing oxidative stress, you create conditions less favorable for fungal infections to establish or spread. The elderberry component adds specific immune-supporting benefits.
What We Like
- Multiple antioxidants for comprehensive protection
- Includes immune-supporting elderberry
- Supports long-term infection prevention
What Could Be Better
- Complex formula with many ingredients
- May overlap with other supplements
Bottom Line: A comprehensive antioxidant formula ideal for supporting immune health and preventing recurrent fungal infections.
How to Choose the Best Supplements for Fungal Infections
When selecting supplements for fungal infections, prioritize those with direct antifungal properties alongside immune-supporting nutrients. Oregano oil is one of the most potent natural antifungals, with extensive research showing effectiveness against various fungal species. Look for standardized extracts containing at least 70% carvacrol, the primary active compound. Typical doses range from 150-600mg daily.
Caprylic acid is another powerful antifungal that works by disrupting fungal cell membranes. It’s particularly effective against Candida overgrowth. Look for pure caprylic acid or combination formulas that include it. Doses typically range from 1000-3000mg daily, divided into 2-3 doses with meals to minimize digestive upset.
Support these direct antifungals with immune-boosting nutrients. Zinc is particularly valuable because it has both direct antifungal properties and supports immune function. Aim for 15-30mg daily. Vitamin D optimizes immune function and enhances antifungal immunity – maintain levels between 40-60 ng/mL through appropriate supplementation. Vitamin C provides antioxidant support and immune function, taken at 1000-2000mg daily in divided doses.
For specific types of fungal infections, consider targeted approaches. Nail fungus benefits from biotin (2500-5000mcg daily) to support healthy nail growth. Skin fungal infections may respond well to topical vitamin E or tea tree oil in addition to internal supplements. Systemic or gut fungal overgrowth often requires probiotics alongside antifungals to restore healthy microbial balance.
Quality matters significantly with antifungal supplements. Choose products from reputable manufacturers with third-party testing, especially for herbs and essential oils where potency and purity vary widely. Start with lower doses and gradually increase to minimize die-off reactions. Work with a healthcare provider to develop a comprehensive treatment plan, especially for persistent or recurrent fungal infections.
Benefits of Supplements for Fungal Infections
The primary benefit of antifungal supplements is providing natural compounds that directly inhibit fungal growth and replication. Oregano oil, caprylic acid, and other natural antifungals work through different mechanisms than pharmaceutical antifungals, making them valuable additions to treatment regimens. They can help reduce fungal load while supporting your immune system’s ability to clear the infection.
Immune support is equally important for fungal infections. Unlike bacterial or viral infections that typically resolve relatively quickly, fungal infections often indicate immune dysfunction or imbalance. Supplements like vitamin D, zinc, and vitamin C help optimize immune function, enabling your body to mount a more effective defense against fungi. This is particularly important for preventing recurrent infections.
Promoting tissue healing and barrier function helps resolve infections faster and prevents spread. Nutrients like zinc, vitamin C, and vitamin A support skin and mucous membrane health, helping damaged tissue heal and strengthening barriers against further fungal invasion. This is especially valuable for skin and nail fungal infections where restoring healthy tissue is crucial.
Finally, supporting overall balance in the body helps prevent fungal overgrowth. Many fungal infections, particularly Candida overgrowth, occur when the normal microbial balance is disrupted. Supplements that support gut health, immune function, and healthy pH balance create an internal environment less favorable for pathogenic fungi, helping prevent both initial infections and recurrences.
Frequently Asked Questions
Can supplements cure fungal infections?
Supplements can help treat fungal infections but may not completely cure severe or systemic infections on their own. For localized superficial infections, natural antifungals combined with immune support may be sufficient. However, serious fungal infections, nail fungus, and systemic infections typically require pharmaceutical antifungals. Supplements work best as complementary support alongside appropriate medical treatment.
What is the most effective natural antifungal supplement?
Oregano oil is considered one of the most potent natural antifungals, with extensive research showing effectiveness against various fungal species including Candida. However, different fungi may respond better to different compounds. A combination approach using oregano oil, caprylic acid, and immune-supporting nutrients often provides better results than any single supplement alone.
How long does it take for antifungal supplements to work?
The timeline varies by infection type and severity. Mild surface fungal infections may show improvement within 2-4 weeks. Nail fungus typically requires 3-6 months of consistent treatment as new healthy nail grows. Systemic or gut Candida overgrowth may take several months to resolve. Consistency is crucial – irregular supplementation rarely provides good results.
Should I take probiotics with antifungal supplements?
Yes, probiotics are highly recommended when taking antifungal supplements, especially for gut-related fungal overgrowth. Antifungals can disrupt your beneficial bacteria along with pathogenic fungi. Taking high-quality probiotics (at least 10 billion CFU daily) helps restore healthy microbial balance and may prevent fungal overgrowth recurrence. Take probiotics at least 2 hours apart from antifungal supplements.
Can I take too much oregano oil?
Yes, excessive oregano oil can cause digestive upset, allergic reactions in sensitive individuals, and may interfere with beneficial gut bacteria if taken in very high doses long-term. Stick to recommended doses (typically 150-600mg daily of standardized extract) and take breaks after 2-3 months of continuous use. If you experience digestive discomfort, reduce the dose or take with meals.
Do antifungal supplements cause die-off symptoms?
Yes, many people experience die-off symptoms (Herxheimer reaction) when taking effective antifungal supplements. As fungi are killed, they release toxins that can cause temporary symptoms like fatigue, headache, digestive upset, or skin breakouts. Start with lower doses and increase gradually to minimize these effects. Drinking plenty of water and supporting detoxification can help manage die-off symptoms.
Can vitamin D help prevent fungal infections?
Research suggests that adequate vitamin D levels support antifungal immunity and may help prevent fungal infections. Vitamin D enhances immune cell function and has been shown to have direct antifungal effects in studies. Maintaining optimal levels (40-60 ng/mL) through supplementation may reduce susceptibility to fungal infections, especially in individuals with recurrent infections.
Should I continue antifungal supplements after the infection clears?
For acute infections, you can typically stop antifungal supplements once the infection fully resolves, though continuing immune-supporting nutrients may help prevent recurrence. For chronic or recurrent fungal issues, alternating different antifungal supplements in cycles while maintaining consistent immune support may provide better long-term results. Work with your healthcare provider to develop an appropriate maintenance plan.
