Best D3 K2 Supplements

Vitamin D3 and K2 work synergistically to support bone health, cardiovascular function, and immune system strength. While D3 helps your body absorb calcium, K2 ensures that calcium is directed to your bones where it belongs rather than accumulating in soft tissues and arteries. This powerful combination has become increasingly popular as research reveals how these two vitamins work together more effectively than either could alone, making D3+K2 supplements an essential consideration for comprehensive health support.

Our Top Picks at a Glance

• Best Overall: Sports Research Vegan D3+K2 — High-quality vegan formula with coconut oil
• Best Value: Micro Ingredients D3+K2 — 300 softgels for extended supply
• Best Premium: Pure Encapsulations D3 & K2 — Pharmaceutical-grade purity

Quick Comparison

Product	Key Ingredients	Form	Servings	Best For
Sports Research D3+K2	5000 IU D3, 100mcg K2	Softgels	60	Vegan users
Micro Ingredients D3+K2	10,000 IU D3, 200mcg K2	Softgels	300	Maximum value
Pure Encapsulations D3 & K2	4000 IU D3, 100mcg K2	Capsules	120	Quality focused
Nature Made D3 K2	5000 IU D3, 100mcg K2	Softgels	30	Trusted brand
Dr. Berg D3 K2	5000 IU D3, 50mcg K2	Capsules	60	Enhanced formula
NOW D3 & K2	1000 IU D3, 45mcg K2	Capsules	120	Lower dose needs
Sports Research D3+K2 30ct	5000 IU D3, 100mcg K2	Softgels	30	Trial size

1. Sports Research Vegan D3+K2 — Best Overall

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Sports Research delivers a breakthrough vegan-friendly formula combining 5,000 IU of plant-based D3 from lichen with 100mcg of MK-7 K2 from fermented chickpeas, all suspended in coconut MCT oil for optimal absorption.

This innovative supplement solves a major challenge in vegan nutrition by providing D3 from non-animal sources without compromising quality or bioavailability. The D3 is sourced from lichen rather than sheep’s wool lanolin, making it truly plant-based, while the K2 comes from natural fermentation of chickpeas. The coconut MCT oil carrier enhances absorption of these fat-soluble vitamins and provides its own metabolic benefits. Sports Research’s commitment to quality is evident through their Vegan Certification, Non-GMO Project Verification, and rigorous third-party testing.

What We Like

• Plant-based D3 from lichen makes it suitable for vegans and vegetarians
• MK-7 form of K2 provides superior bioavailability and longer half-life
• Coconut MCT oil enhances absorption while supporting ketone production

What Could Be Better

• Softgel size may be large for some users to swallow
• Premium vegan ingredients result in higher cost per serving

Bottom Line: The gold standard for those seeking plant-based D3+K2 supplementation without compromising on quality or effectiveness.

2. Micro Ingredients D3+K2 — Best Value

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Micro Ingredients offers exceptional value with 300 softgels providing 10,000 IU of vitamin D3 and 200mcg of K2 MK-7, delivering a 10-month supply at an incredibly competitive price point.

This extra-strength formula provides double the D3 and K2 content of standard supplements, making it ideal for those with higher needs or significant deficiency. The inclusion of virgin coconut oil enhances absorption of these fat-soluble vitamins while providing additional health benefits. Micro Ingredients’ commitment to purity is demonstrated through their third-party lab testing and non-GMO, gluten-free formulation. The massive 300-softgel count means you won’t need to reorder for nearly a year.

What We Like

• 300 softgels provide nearly 10 months of supply for exceptional value
• Extra-strength 10,000 IU D3 effectively addresses deficiency
• Third-party tested for purity and made without common allergens

What Could Be Better

• 10,000 IU dose may be excessive for maintenance needs
• Large bottle size requires adequate storage space

Bottom Line: An outstanding choice for those with significant vitamin D deficiency or who simply want maximum value with minimal reordering.

3. Pure Encapsulations D3 & K2 — Best Premium

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Pure Encapsulations delivers pharmaceutical-grade quality with 4,000 IU of D3 and 100mcg of K2 in hypoallergenic capsules that meet the strictest purity standards in the supplement industry.

This premium supplement is manufactured to pharmaceutical standards, using only ingredients that pass rigorous third-party testing from trusted suppliers. The 4,000 IU dose of vitamin D3 provides robust support for immune function and bone health, while the 100mcg of menaquinone-7 K2 ensures proper calcium utilization. Pure Encapsulations’ hypoallergenic approach means the formula contains no wheat, gluten, eggs, peanuts, magnesium stearate, hydrogenated fats, artificial sweeteners, colors, or preservatives.

What We Like

• Pharmaceutical-grade purity with premium ingredient sourcing
• Hypoallergenic capsules suitable for sensitive individuals
• 120-capsule count provides 4-month supply

What Could Be Better

• Premium quality comes with correspondingly higher price
• Capsule form may be less convenient than softgels for some

Bottom Line: The ultimate choice for those who prioritize purity and quality above all else and are willing to invest in pharmaceutical-grade supplementation.

4. Nature Made D3 K2 — Best Trusted Brand

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Nature Made, the #1 pharmacist-recommended vitamin brand, combines 5,000 IU of vitamin D3 with 100mcg of vitamin K2 in convenient softgels designed for those with higher vitamin D needs.

This supplement is specifically formulated for individuals with diagnosed vitamin D deficiency or those with significantly elevated requirements, providing a therapeutic dose that research shows works better for bone health when D3 and K2 are combined. Nature Made’s reputation is built on decades of quality manufacturing and extensive quality testing. The formula contains no synthetic dyes or artificial flavors, and is gluten-free, making it suitable for most dietary needs.

What We Like

• #1 pharmacist-recommended brand provides consumer confidence
• Therapeutic 5,000 IU dose addresses deficiency effectively
• K2 addition helps direct calcium to bones for enhanced bone health

What Could Be Better

• 30-day supply requires monthly reordering
• Contains soybean and corn oil which some prefer to avoid

Bottom Line: A reliable choice from a trusted brand, particularly suitable for those with higher vitamin D needs or deficiency.

5. Dr. Berg D3 K2 — Best Enhanced Formula

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Dr. Berg’s Maximum Strength formula goes beyond basic D3+K2 by including essential cofactors like magnesium, B6, and zinc that help your body properly absorb, activate, and utilize vitamin D.

This comprehensive supplement provides 5,000 IU of naturally-derived D3 and 50mcg of MK-7 K2, enhanced with a unique blend of supporting nutrients. The addition of magnesium is particularly important as it’s required for vitamin D activation, while vitamin B6 and zinc support the enzymatic processes involved in vitamin D metabolism. MCT powder and ox bile further enhance absorption of these fat-soluble vitamins, ensuring maximum bioavailability.

What We Like

• Comprehensive formula includes cofactors for optimal D3 utilization
• MCT powder and ox bile enhance fat-soluble vitamin absorption
• Manufactured in cGMP-certified USA facilities with 4X lab testing

What Could Be Better

• Complex formula increases capsule size and price
• May provide redundant nutrients if supplementing elsewhere

Bottom Line: An intelligent choice for those seeking comprehensive vitamin D support with all necessary cofactors in one convenient supplement.

6. NOW D3 & K2 — Best for Lower Dose Needs

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NOW Foods provides a balanced 1,000 IU of D3 with 45mcg of K2 in vegetarian capsules, making it ideal for daily maintenance rather than deficiency correction.

This moderate-dose formula is perfect for those who need consistent vitamin D support without the higher doses recommended for deficiency states. The 1,000 IU of D3 combined with 45mcg of MK-4 K2 supports bone health and cardiovascular function while being gentle enough for daily long-term use. NOW’s GMP Quality Assured certification and extensive third-party testing ensure consistent quality, and the formula is kosher and soy-free.

What We Like

• Moderate dose suitable for maintenance and sensitive individuals
• 120 capsules provide 4-month supply for excellent value
• Non-GMO, kosher, and soy-free formulation

What Could Be Better

• 1,000 IU dose insufficient for deficiency correction
• Uses MK-4 form of K2 which has shorter half-life than MK-7

Bottom Line: The right choice for those with adequate vitamin D levels who want daily maintenance support at a moderate dose.

7. Sports Research D3+K2 30-Count — Best Trial Size

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Sports Research offers their premium vegan D3+K2 formula in a convenient 30-count bottle, perfect for those wanting to try the product before committing to a larger supply.

This trial-size version contains the same high-quality plant-based D3 from lichen and MK-7 K2 from fermented chickpeas as the larger bottle, suspended in coconut MCT oil for optimal absorption. The 30-softgel size is ideal for testing tolerance, determining if the vegan formula works for you, or having a travel-friendly supply. It maintains all the quality certifications including Vegan Certified, Non-GMO Project Verified, and third-party testing.

What We Like

• One-month supply allows product trial without large commitment
• Same premium vegan formula as larger bottle
• Convenient size for travel or sampling

What Could Be Better

• Higher per-serving cost compared to larger bottle
• Requires monthly reordering if continuing long-term

Bottom Line: Perfect for those wanting to test Sports Research’s premium vegan formula before investing in a larger supply.

How to Choose

Vitamin D3 dosage requirements vary significantly based on your current status, sun exposure, and individual needs. For maintenance in individuals with adequate levels, 1,000-2,000 IU daily is typically sufficient. Those with mild deficiency or limited sun exposure may benefit from 2,000-4,000 IU daily, while significant deficiency often requires 5,000-10,000 IU under medical supervision. It’s important to have your vitamin D levels tested before starting high-dose supplementation to ensure you’re taking an appropriate amount.

The form of vitamin K2 included in your supplement significantly impacts its effectiveness. MK-7 (menaquinone-7) is generally superior to MK-4 due to its longer half-life and better bioavailability, remaining active in your body for several days compared to just a few hours for MK-4. Most quality D3+K2 supplements use MK-7 at doses ranging from 45-200mcg. The ideal ratio isn’t firmly established, but formulas providing 100mcg of K2 MK-7 per 5,000 IU of D3 are commonly used and well-supported by research.

Absorption enhancers can make a substantial difference in how well your body utilizes these fat-soluble vitamins. Quality supplements include a fat source like MCT oil, coconut oil, olive oil, or other lipids that facilitate vitamin D3 and K2 absorption. Some formulas also include additional cofactors like magnesium, zinc, or boron that support vitamin D metabolism and activation. While these additions increase cost, they can significantly improve the supplement’s effectiveness, particularly if you’re deficient in these cofactors.

Dietary preferences and restrictions should guide your product selection. For vegans and vegetarians, finding D3+K2 supplements with plant-based D3 from lichen rather than lanolin is crucial. Similarly, K2 can be sourced from fermented chickpeas instead of animal products. Those with allergies or sensitivities should look for gluten-free, soy-free, and dairy-free options. Quality certifications like Non-GMO Project Verified, Vegan Certified, or third-party testing provide additional assurance that the product meets your standards.

Benefits

Vitamin D3 and K2 work synergistically to support optimal bone health through complementary mechanisms. D3 enhances calcium absorption in the intestines, increasing the calcium available for bone building. However, without adequate K2, this absorbed calcium may not reach the bones efficiently. K2 activates proteins like osteocalcin that bind calcium to bone matrix, and matrix GLA protein that prevents calcium from depositing in soft tissues. This partnership ensures calcium is directed to bones where it’s needed while keeping it out of arteries and other soft tissues where it could cause harm.

Cardiovascular health benefits extend beyond calcium regulation, as both vitamins support arterial flexibility and healthy blood pressure. K2’s role in activating matrix GLA protein helps prevent arterial calcification, maintaining vessel elasticity and proper blood flow. Vitamin D3 supports cardiovascular function through multiple pathways including regulation of the renin-angiotensin system that controls blood pressure. Together, these vitamins help maintain cardiovascular health by supporting proper calcium distribution and vascular function.

Immune system support represents one of vitamin D3’s most important functions, with vitamin D receptors present on immune cells throughout the body. Adequate D3 levels help modulate both innate and adaptive immune responses, supporting the body’s ability to respond to pathogens while preventing excessive inflammatory reactions. Research consistently shows that maintaining optimal vitamin D status correlates with better immune function and reduced susceptibility to respiratory infections. This immune support is particularly important during winter months when sun exposure is limited.

Beyond these primary benefits, D3 and K2 support muscle function, cognitive health, mood regulation, and overall vitality. Vitamin D receptors are present in muscle tissue, where adequate D3 levels support strength and coordination. D3 also plays roles in neurotransmitter synthesis and neuroplasticity, potentially supporting cognitive function and mood. The combination of improved bone density, cardiovascular health, immune function, and muscle strength contributes to healthy aging and maintenance of independence as we grow older.

Frequently Asked Questions

Should vitamin D3 and K2 be taken together?

Yes, taking vitamin D3 and K2 together is highly recommended and more effective than taking either alone. D3 increases calcium absorption, but K2 is needed to direct that calcium to bones rather than soft tissues and arteries. Research shows that the combination works synergistically for bone health, with studies demonstrating better outcomes when both vitamins are present. Taking them together also reduces the theoretical risk of arterial calcification that might occur with high-dose D3 supplementation alone, making the combination both more effective and safer.

What is the best ratio of vitamin D3 to K2?

While no definitive ratio has been established through research, most quality supplements provide approximately 100mcg of K2 MK-7 per 5,000 IU of vitamin D3. This ratio has been used successfully in numerous supplements and appears to provide adequate K2 to support D3’s effects on calcium metabolism. Some formulas use higher K2 amounts (up to 200mcg) with 10,000 IU of D3. The most important factor is ensuring you’re getting adequate amounts of both vitamins rather than adhering to a specific ratio.

When should I take D3 K2 supplements?

D3 and K2 are fat-soluble vitamins that absorb best when taken with a meal containing dietary fat. Taking your supplement with breakfast or dinner that includes healthy fats like avocado, nuts, olive oil, or fatty fish will maximize absorption. Consistency is more important than timing—taking your supplement at the same time daily helps establish a routine and ensures regular intake. Some people prefer morning dosing as vitamin D may affect sleep in sensitive individuals, though this effect is uncommon.

How long does it take for vitamin D3 K2 to work?

Vitamin D3 levels begin rising within hours of supplementation, with significant increases typically visible on blood tests within 2-4 weeks. However, the full benefits for bone health, immune function, and other outcomes develop more gradually over 3-6 months of consistent supplementation. K2’s effects on calcium metabolism also develop over weeks to months. For optimal results, plan to supplement consistently for at least 3 months before assessing effectiveness, and have your vitamin D levels retested after 8-12 weeks to ensure you’ve reached an adequate range.

Can you take too much vitamin D3 and K2?

Yes, excessive vitamin D3 can cause toxicity, though this typically requires sustained intake of very high doses (usually above 10,000 IU daily for extended periods). Symptoms of vitamin D toxicity include nausea, vomiting, weakness, and potentially dangerous calcium buildup in blood and soft tissues. K2 has a much wider safety margin with no established upper limit, making toxicity extremely unlikely. To avoid excess, have your vitamin D levels tested regularly and don’t exceed 10,000 IU daily without medical supervision. K2 supplementation up to 200mcg daily is considered very safe.

Is MK-7 or MK-4 better for vitamin K2?

MK-7 is generally considered superior to MK-4 for supplementation due to its longer half-life and better bioavailability. MK-7 remains active in the body for several days, providing sustained K2 levels with once-daily dosing. MK-4 has a half-life of only a few hours, requiring multiple daily doses for consistent blood levels. Research also suggests MK-7 is better absorbed and more effectively raises vitamin K status. Most quality D3+K2 supplements use MK-7 sourced from fermented soybeans or chickpeas.

Do I need to take calcium with D3 and K2?

Not necessarily—D3 and K2 help your body utilize dietary calcium more effectively, so many people don’t need additional calcium supplementation if they consume adequate calcium-rich foods. In fact, excessive calcium supplementation without adequate K2 may increase the risk of arterial calcification. Focus first on getting 1,000-1,200mg of calcium daily from food sources like dairy, leafy greens, and fortified foods. Only add calcium supplementation if dietary intake is insufficient, and always ensure adequate K2 intake to direct that calcium appropriately.

Can vegans take D3 K2 supplements?

Yes, vegan-friendly D3+K2 supplements are available, though traditional D3 is often sourced from sheep’s wool lanolin. Vegan D3 is derived from lichen, a plant-like organism that naturally produces vitamin D3. K2 MK-7 can be sourced from fermented chickpeas or other plant-based fermentation rather than animal products. Look for supplements specifically labeled as vegan or plant-based, and check that the softgel capsule itself is also vegan (many use plant-based cellulose rather than animal-derived gelatin). Several quality brands now offer complete vegan D3+K2 formulations.

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