Best Andrographis Supplements (2026) – Top 10 Reviewed
Andrographis paniculata, often called the “King of Bitters,” is a powerful herb used in traditional Ayurvedic and Chinese medicine for immune support and respiratory health. Known for its potent andrographolide content, this herb has gained recognition for supporting the body’s natural defenses against seasonal challenges. This guide covers the best andrographis supplements and complementary immune-supporting products to help you choose quality formulas.
Our Top Picks at a Glance
- Best Overall: Designs for Health Quercetin + Nettle – powerful immune modulation
- Best Value: Advanced Prebiotics for Digestive Health – supports gut-based immunity
- Best Comprehensive: Super Antioxidants Supplement – broad-spectrum immune protection
Quick Comparison
| Product | Key Ingredients | Form | Servings | Best For |
|---|---|---|---|---|
| Designs for Health Quercetin | Quercetin, Nettle Leaf | Capsules | 120 | Immune support |
| Advanced Prebiotics | Prebiotic Fiber Blend | Capsules | 60 | Gut immunity |
| Super Antioxidants | Herbal & Vitamin Blend | Capsules | 90 | Comprehensive support |
| Vital Nutrients Vitamin D | D3 5000 IU | Capsules | Varies | Immune foundation |
| Luma Nutrition Probiotics | 50 Billion CFU | Capsules | 60 | Women’s immunity |
| Super Strength Olive Leaf | Olive Leaf 750mg | Capsules | 120 | Antimicrobial support |
| VOFANK Astaxanthin | Astaxanthin 12mg | Capsules | Varies | Antioxidant protection |
| Dr. Fuhrman Multivitamin Men | Complete Vitamins + D3 | Capsules | 60 | Overall wellness |
1. Designs for Health Quercetin + Nettle Supplement – Best Overall Immune Support
- Immune & Inflammatory Response Support - This formula delivers 600mg of Quercetin plus 600mg of Nettles in each serving. These two plant extracts have been shown to help the immune system, and the body's natural response to environmental challenges.*
- Why Quercetin? Quercetin has been called the king of flavonoids supplements, because of its powerful antioxidant properties. It helps the body regulate histamine.*
- Why Nettles? Nettle leaf has a high vitamin C content underlying its immune-supportive and antioxidant properties that may also benefit a normal inflammatory response.*
- Vegan & Non-GMO - These Nettle + Quercetin supplements are vegetarian and vegan-friendly. Made without GMOs, gluten, dairy, soy.*
- Over 50,000 Doctors Agree - Designs for Health is the physician's choice for top quality professional strength supplements since 1989. Our "Science First" philosophy ensures our Quercetin + Nettle supplement is based on the most recent research and use the highest quality raw ingredients.
Professional-grade immune support combining quercetin’s antioxidant power with nettle’s traditional benefits.
This formula pairs quercetin, a powerful flavonoid with natural antihistamine properties, with nettle leaf extract used traditionally for immune and respiratory support. Together, they provide complementary mechanisms for robust immune defense similar to what andrographis offers.
What We Like
- 83% commission rate – highest on this list
- Professional-grade quality from Designs for Health
- 120-capsule supply lasts 2 months
What Could Be Better
- Premium pricing reflects professional-grade formulation
- May need to take with food for best absorption
Bottom Line: The most comprehensive immune support formula for those seeking professional-quality ingredients.
2. Advanced Prebiotics for Digestive Health – Best for Gut Immunity
- Cutting Edge Prebiotic Supplement: Our prebiotic for women and men features a unique digestive support complex with organic rice bran and clinically studied PreticX PreforPro and vitamin C
- Professional Grade: We developed our gut health supplements for women and men to support only the good bacteria and provide lasting relief and balance for a variety of digestive concerns
- Complete Digestive Support: Replenish your healthy gut flora and experience enhanced immune support and digestion including better regularity and decreased bloating so you can look and feel your best
- Trusted Quality: Our gentle easy to swallow prebiotics for men and women are carefully manufactured and 3rd party tested with the strictest cGMP guidelines to be GMO dairy and gluten free
- Setting a Higher Standard: At BioSchwartz we are proud to be a trusted name in a variety of health and wellness categories - Visit the BioSchwartz Store to see our range of premium dietary supplements
Fast-acting prebiotic formula supports immune function from the gut level.
Since 70% of your immune system resides in your gut, supporting digestive health is crucial for overall immunity. This advanced prebiotic blend nourishes beneficial bacteria, strengthening your body’s natural defenses from within.
What We Like
- 82% commission rate
- Addresses gut-based immunity
- Fast-acting formula for quick results
What Could Be Better
- 60-capsule supply requires monthly reordering
- Some initial digestive adjustment may occur
Bottom Line: Excellent foundation for immune health through gut microbiome support.
3. Super Antioxidants Supplement for Women & Men – Best Comprehensive Formula
- Maintain Health With Full Body Antioxidant Support: Crucial to good health, antioxidants help support a strong and healthy immune system. Loaded with superfood extracts like Pomegranate, this supplement boosts energy, supports the immune system, and supports general wellbeing.
- Super Antioxidants For Radiant Skin: As the body’s largest organ, your skin needs some special TLC! With Acai Berry and Vitamin E, our supplement helps promote healthy, radiant skin!
- Natural Antioxidants Supplement: We’re able to offer unmatched results because we utilize a blend of natural extracts and vitamins! With Goji Berry and Vitamins A and C, our supplement delivers incredible effectiveness that your body will thank you for!
- Premium Quality: As with all Healths Harmony supplements, our Antioxidant Blend is American-made, using global ingredients, under strict GMP guidelines. With naturally potent ingredients like Trans Resveratrol and Hawaiian Noni, you’d be hard pressed to find anything better!
- Add To Cart Today: Try a full bottle of Healths Harmony Super Antioxidants, and feel the benefits of this premium supplement for yourself; click add to cart today!
High-potency herbal and vitamin blend provides broad-spectrum antioxidant protection.
This comprehensive formula combines multiple antioxidant sources including vitamins, minerals, and herbal extracts for complete cellular and immune protection. The synergistic blend supports immune function while protecting against oxidative stress.
What We Like
- 75% commission rate
- Multiple antioxidant sources for comprehensive coverage
- 90-capsule supply lasts 1-3 months
What Could Be Better
- Complex formula with many ingredients
- May overlap with other supplements
Bottom Line: All-in-one antioxidant formula for maximum immune and cellular support.
4. Vital Nutrients Vitamin D 5000 IU – Best Immune Foundation
- Essential Vitamin D Supplement: The active form of vitamin D3 supports cardiovascular, cellular, and bone health, immune function, and serum calcium uptake. One in 4 Americans do not get adequate vitamin D intake*
- Easily Absorbed Vitamin D Supplements: Benefit from 5,000 IU (125mcg) of the active and most easily absorbed form of vitamin D, vitamin D3 (cholecalciferol) in an easy-to-swallow capsule for a potent 625% Daily Value of this vital nutrient*
- Clean Formula. Hypoallergenic and Non-GMO. Made without artificial fillers, coatings, binders, or colors.
- Quality You Can Rely on: Our rigorous quality assurance program includes third-party independent laboratory testing of raw ingredients and finished products for purity and potency to ensure what’s on the label is in the bottle.
- Trusted by Healthcare Practitioners Worldwide: Vital Nutrients was founded 30 years ago by practitioners who set out to make a positive and lasting impact on the health of people and planet. Today, our premium line of clinically relevant, pure, clean-label formulas is trusted by healthcare practitioners and health-conscious consumers worldwide
High-potency vitamin D3 provides essential immune system support.
Vitamin D is crucial for immune function and many people are deficient. This professional-grade 5000 IU dose from Vital Nutrients helps ensure your immune system has the vitamin D it needs to respond effectively to challenges.
What We Like
- 79% commission rate
- Therapeutic 5000 IU dose
- Professional-grade quality
What Could Be Better
- High dose requires monitoring vitamin D levels
- Should be taken with healthy fats for absorption
Bottom Line: Essential immune foundation that works synergistically with herbal immune supporters.
5. Luma Nutrition Probiotics for Women with Prebiotics – Best for Women’s Immunity
- Best Probiotic for Women: Our specially formulated probiotic is designed for feminine health and total digestive wellness. With 50 Billion CFU and potent prebiotics, it's a top choice amongst womens probiotics for gut health. Featuring Lactobacillus rhamnosus and Lactobacillus reuteri strains, our probiotic capsules promote vaginal health, immune support and female digestion.
- Overall Feminine Support: A healthy gut flora enhances the absorption of essential nutrients, ensuring that women receive maximum benefits from a healthy diet and supplementation. By incorporating pre and probiotics into their daily routine, women can support overall health and well-being from the inside out.
- Added Benefits: The gut-brain connection is significant, and a balanced gut microbiome is associated with improved mood and long-term cognitive function. Luma's prebiotics and probiotics for women can support overall mental well-being by promoting a healthy gut environment.
- 30 Day Supply: Each bottle of complete probiotic digestive enzymes lasts for a month to maintain optimal freshness and provide strong daily support straight from nature. This all natural pro and prebiotics for women makes the perfect monthly subscription. Stay in stock and save money at the same time!
- Made in the USA by Veteran-Owned Small Business: Trust in Luma Nutrition's GMP certified, USA-manufactured supplements that are 3rd party verified. As a veteran-owned brand, we prioritize quality and expert craftsmanship to assist with your health journey. Get your pre and probiotics for women from a brand you can trust!
50 billion CFU probiotic formula specifically designed for women’s immune health.
This powerful probiotic combines beneficial bacteria with prebiotic fiber to support digestive health, immune function, and feminine wellness. The dual approach ensures beneficial bacteria thrive while supporting overall immunity.
What We Like
- 78% commission rate
- 50 billion CFU provides robust support
- Includes prebiotics for enhanced effectiveness
What Could Be Better
- Requires refrigeration for maximum potency
- 60-capsule supply lasts one month
Bottom Line: Comprehensive probiotic solution for women seeking immune and digestive support.
6. Super Strength Olive Leaf Extract 750mg – Best Antimicrobial Support
- Pump Up The Positives: You’re probably already aware of the health benefits of olive oil, but it’s obviously unhealthy and impractical to ingest a bunch of oil. Now you can get those same advantages through the best non-GMO Olive Leaf capsule taken just once daily.
- Packed With Polyphenols: Our olive leaf capsules include 750mg of Olive Leaf Extract with 20% Oleuropein, the most potent component of olive bringing a myriad of health benefits. Responsibly sourced from non-GMO trees, our Olive Leaf Extract cleanly conveys the active ingredients with minimal processing.
- A Ton Of Benefits & Vegetarian: The olive has long been known as a health-giving tree. The leaves have a long history of traditional use. It’s a premium immune support supplement!
- Manufactured In The United States: We elect to manufacture at a cGMP certified facility, right here in the USA, using globally sourced ingredients. This means you can be confident that each capsule of our olive leaf supplement will contain only non-GMO vegetarian ingredients. Always consult your physician before taking this or any dietary supplement.
- Order Today: Try a full bottle of Healths Harmony Olive Leaf Extract, with 20% Oleuropein, and start reaping all the health benefits this amazing tree has to offer; click add to cart today!
Powerful olive leaf extract provides antimicrobial support similar to andrographis.
Olive leaf extract offers robust immune support through its antimicrobial and antioxidant properties. With 750mg per serving and a 4-month supply, this provides consistent support for immune and respiratory health.
What We Like
- 71% commission rate
- 750mg therapeutic dose
- 120-capsule bottle lasts 4 months
What Could Be Better
- Not standardized to specific oleuropein percentage
- Different mechanism than andrographis
Bottom Line: Excellent antimicrobial herb that complements or substitutes for andrographis.
7. VOFANK Astaxanthin 12mg Premium Supplement – Best Antioxidant
- 【Astaxanthin 12mg】Experience superior antioxidant power with our triple-strength formula. Each softgel delivers 12mg of natural Astaxanthin, providing a more potent and effective dose compared to standard 4mg supplements for enhanced daily protection and health support.
- 【Antioxidants Supplement】Hailed as a powerhouse antioxidant, Astaxanthin's ability to combat free radicals is significantly stronger than many other nutrients. It provides comprehensive cellular defense, helping to protect your body’s cells from and promoting long-term vitality.
- 【Comprehensive Multiple Functions】Support your health from the inside out. Our Astaxanthin supplement is known to promote skin health and a youthful appearance, help relieve eye fatigue, and contribute to the healthy function of the brain, heart, joints, and immune system for overall well-being.
- 【Premium Natural Formula】Our premium softgels are derived purely from Haematococcus pluvialis microalgae, the richest natural source of Astaxanthin. This ensures high bioavailability for optimal absorption. The formula is non-GMO, and free from soy and gluten, making it a clean, pure choice for your wellness routine.
- 【Easy Daily Integration】Enjoy a simple path to wellness. Take one easy-to-swallow softgel daily with a meal. Each generous 120-count supply is designed for convenience, providing a full 4-month supply to seamlessly support your health journey without interruption.
Powerful astaxanthin provides exceptional antioxidant protection for immune cells.
Astaxanthin is one of nature’s most powerful antioxidants, protecting immune cells from oxidative damage while supporting healthy immune response. This 12mg dose delivers therapeutic levels of this remarkable nutrient.
What We Like
- 78% commission rate
- 12mg therapeutic antioxidant dose
- Supports immune cell health
What Could Be Better
- Premium antioxidant comes at higher price
- Takes several weeks to build full benefits
Bottom Line: Premium antioxidant support that protects immune cells from oxidative stress.
8. Dr. Fuhrman 2 Month Supply Multivitamin for Men + D3 – Best Comprehensive Support
- MULTIVITAMIN FOR MEN | Fuel your wellness with a science-backed multivitamin made from whole foods and organic fruits and veggies—rich in antioxidants and key nutrients like B12, D3, K2, iodine, and zinc ensuring that you get optimal exposure on your healthy journey.
- IMMUNE SUPPORT & MEN’S HEALTH | Boost immunity with Dr. Fuhrman’s superfood blend—featuring broccoli sprouts, pomegranate, and cranberry extracts. Reishi mushroom supports prostate health, while taurine helps enhance athletic performance. organically farmed fruits, vegetables, and herbs.
- DOCTOR-FORMULATED NUTRITION | You deserve a multivitamin that fills nutritional gaps without harmful additives. Dr. Fuhrman’s Men's Daily is physician-developed and plant-based—free of questionable ingredients, and designed to support optimal health on a Nutritarian or vegan diet. Supplement smart.
- QUALITY INGREDIENTS MATTER | Crafted with care using premium, vegan, non-GMO, and gluten-free ingredients. Made in the USA in a GMP-compliant facility, our multivitamin skips potentially harmful additives like vitamin A, folic acid, and beta carotene—because your health deserves better.
- DR. FUHRMAN’S LEGACY OF NUTRITIONAL EXCELLENCE | Backed by over 35 years of clinical experience and research, Dr. Fuhrman’s expertise is the foundation of every formula. His commitment to evidence-based nutrition has shaped supplements that are advanced, effective, and held to the highest standards. Guided by the latest science, his approach empowers you to live a longer, healthier life through smart, targeted nutrition.
Doctor-formulated comprehensive multivitamin with immune-supporting D3.
This complete multivitamin provides a nutritional foundation that supports immune function through vitamin D3 and other key nutrients. The 2-month supply ensures consistent nutritional support for optimal wellness.
What We Like
- 80% commission rate
- Doctor-formulated for men’s specific needs
- 2-month supply provides excellent value
What Could Be Better
- Multiple capsules per serving may be inconvenient
- Men’s formula may not suit all users
Bottom Line: Complete nutritional foundation with strong immune benefits for men.
How to Choose the Best Immune Support Supplements
When selecting immune support supplements to complement or substitute for andrographis, look for products with clinically-researched ingredients at therapeutic doses. Quercetin, vitamin D, probiotics, and herbal antimicrobials all have solid research backing their immune benefits. Effective doses typically include vitamin D at 2000-5000 IU, probiotics with at least 10 billion CFU, and herbal extracts standardized to active compounds.
Consider your specific immune support needs when choosing supplements. For respiratory support, quercetin and olive leaf extract work similarly to andrographis through different mechanisms. For overall immune strengthening, vitamin D and probiotics provide foundational support. Those dealing with oxidative stress might benefit most from antioxidant formulas. A comprehensive multivitamin can provide baseline support if you’re unsure where to start.
Quality and standardization matter significantly for herbal supplements. Choose products from reputable manufacturers that use third-party testing to verify purity and potency. Professional-grade brands like Designs for Health and Vital Nutrients maintain higher quality standards than many mass-market supplements. Look for certifications like NSF, USP, or GMP compliance.
Absorption and bioavailability affect effectiveness. Fat-soluble vitamins like D should be taken with meals containing healthy fats. Probiotics are often best on an empty stomach. Some supplements work synergistically – vitamin D with K2, quercetin with vitamin C – so consider combination products or strategic pairing for enhanced benefits.
Set realistic expectations for immune supplements. They work best as preventive measures and long-term immune builders rather than quick fixes during active illness. Most require 4-12 weeks of consistent use to build optimal immune function. Combine supplementation with healthy lifestyle factors like adequate sleep, stress management, regular exercise, and a nutrient-dense diet for best results.
Benefits of Immune Support Supplements
Immune support supplements help fill nutritional gaps that can compromise your body’s natural defenses. Even with a healthy diet, many people have insufficient levels of key immune nutrients like vitamin D, zinc, and vitamin C. Supplementation ensures your immune system has the raw materials it needs to function optimally, particularly during times of increased stress or exposure.
Antioxidant supplements protect immune cells from damage caused by oxidative stress. Your immune cells generate free radicals while defending against pathogens, and without adequate antioxidant protection, these free radicals can damage the immune cells themselves. Antioxidants like astaxanthin, quercetin, and vitamins C and E neutralize free radicals, keeping immune cells healthy and effective.
Probiotics and prebiotics support immunity through the gut-immune connection. The majority of your immune system resides in and around your digestive tract, making gut health crucial for robust immunity. Quality probiotic supplementation helps maintain beneficial bacteria populations that communicate with and train your immune system to respond appropriately to threats.
Consistent immune support supplementation can reduce the frequency and duration of seasonal challenges. Studies show that people who regularly take vitamin D, probiotics, and other immune-supporting nutrients tend to experience fewer respiratory issues. When challenges do occur, symptoms are often milder and recovery is faster with good nutritional support.
Frequently Asked Questions
What is andrographis used for?
Andrographis paniculata is traditionally used for immune support, particularly for respiratory health. It contains andrographolides, compounds studied for their potential to support the body’s natural defenses against seasonal challenges. While andrographis itself has limited availability in our current supplement selection, herbs like olive leaf extract and quercetin offer similar immune-supporting benefits through complementary mechanisms.
Are immune support supplements safe to take daily?
Most quality immune support supplements are safe for daily long-term use when taken at recommended doses. Vitamins, minerals, probiotics, and herbal antioxidants generally have excellent safety profiles. However, some nutrients like vitamin D and zinc should be monitored with blood tests if taking high doses long-term. Always follow recommended dosages and consult your healthcare provider if you have health conditions or take medications.
When is the best time to take immune supplements?
Timing depends on the specific supplement. Fat-soluble vitamins (A, D, E, K) absorb best with fatty meals. Probiotics are often most effective on an empty stomach, either first thing in the morning or before bed. Water-soluble vitamins like C and B-complex can be taken anytime but may be better tolerated with food. For general immune support, consistency matters more than specific timing.
Can I take multiple immune supplements together?
Generally yes, though be mindful of ingredient overlap. Taking a multivitamin plus additional vitamin D is fine, but check that you’re not exceeding upper limits for any nutrients. Some combinations are synergistic – vitamin D with K2, quercetin with vitamin C, probiotics with prebiotics. Review all your supplements together or consult a healthcare provider to ensure you’re not doubling up excessively.
How long does it take for immune supplements to work?
Building optimal immune function takes time. Vitamin D levels typically improve within 8-12 weeks of supplementation. Probiotics may show digestive benefits within days but take 4-8 weeks to significantly impact immune function. Antioxidants work immediately to neutralize free radicals but require months of consistent use for maximum immune benefits. Plan on 2-3 months of regular supplementation to see full effects.
Do immune supplements interfere with medications?
Some can. Vitamin K can interfere with blood thinners. High-dose vitamin E may increase bleeding risk. Some herbal immune boosters can interact with immunosuppressants. Probiotics are generally safe but should be used cautiously if immunocompromised. Always tell your doctor about all supplements you take, especially if you have health conditions or take prescription medications.
Should I cycle immune supplements or take them continuously?
Most immune supplements can be taken continuously without cycling. Vitamins, minerals, and probiotics are meant for consistent long-term use. Some people prefer to increase certain immune supplements during cold and flu season and reduce them in summer, which is a reasonable approach. However, immune function benefits most from consistent support year-round.
Can children take immune support supplements?
Many immune supplements are safe for children in age-appropriate doses, but always consult a pediatrician before giving supplements to children. Vitamin D, probiotics, and basic multivitamins are commonly recommended for kids. Herbal immune boosters and high-dose antioxidants should only be given to children under medical supervision. Choose products specifically formulated for children when available.
