Best Anti-Aging Supplements for Men (2026) – Top 10 Reviewed
Men face unique aging challenges, from declining testosterone levels and muscle mass loss to prostate health concerns and cardiovascular changes. The right supplements can help you maintain vitality, support cellular health, and optimize performance as you age. This guide reviews the best anti-aging supplements formulated specifically to address men’s health needs throughout the aging process.
Our Top Picks at a Glance
- Best Overall: Selerb NAD+ with Resveratrol — comprehensive men’s longevity formula
- Best Value: Sugar Free Multivitamin for Men 50 Plus — methylated nutrients with CoQ10
- Best Premium: PS Longevity Multivitamin — 27 vital anti-aging nutrients
Quick Comparison
| Product | Key Ingredients | Form | Servings | Best For |
|---|---|---|---|---|
| Selerb NAD+ Supplements | NAD+, Resveratrol, Nitric Oxide | Capsules | 60 | Prostate & cellular health |
| Sugar Free Multivitamin Men 50+ | Methylated vitamins, CoQ10, Omega-3 | Gummies | 60 | Overall men’s health |
| PS Longevity Multivitamin | Urolithin A, CoQ10, NR | Capsules | 60 | Comprehensive longevity |
| Beet Root with CoQ10 | Beetroot, CoQ10, Pomegranate | Gummies | 60 | Heart & circulation |
| Hawthorn Berry Capsules | Hawthorn Berry, Leaf, Flower | Capsules | 120 | Heart health |
| Juvenon Cellular Health | Acetyl L-Carnitine, Biotin | Tablets | 60 | Heart & brain support |
| Quercetin + Nettle | Quercetin, Nettle Leaf | Capsules | 90 | Antioxidant support |
| Quercetin 500mg | Quercetin Dihydrate | Capsules | 120 | Cellular protection |
| AEON Liposomal NAD+ | NAD+, NR, Resveratrol, Quercetin | Capsules | 60 | Multi-targeted longevity |
| NOVOS Core Longevity Mix | 12 Longevity Ingredients | Powder | 30 | Comprehensive aging support |
1. Selerb NAD+ Supplements for Men — Best Overall
- NAD Supplement for Cellular Energy: This advanced NAD supplement for men features liposomal NAD+ and CoQ10 to fuel cellular energy and support healthy aging. Enhanced with trans-resveratrol, this NAD resveratrol supplement also provides antioxidant support to help reduce fatigue and promote long-term wellness.
- Formulated with L-Arginine, L-Citrulline, Turmeric, and adaptogenic herbs like Maca Root and Ashwagandha, this blend works as an NMN alternative to support your body’s natural nitric oxide production. Adequate nitric oxide promotes oxygen delivery and inner balance — helping you stay resilient all day.
- Promotes Healthy Circulation and Inner Energy: This NAD for men formula works to promote healthy blood flow and circulation. With no added stimulants, it helps support your body’s natural rhythm—so you can feel stronger, more confident, and ready for life’s demands.
- Prostate and Urinary Health Support: Saw palmetto, stinging nettle, beta-sitosterol , and lycopene supplements for men provide comprehensive support for prostate health and urinary tract comfort. This men’s wellness complex helps maintain balance and ease for daily confidence and comfort.
- Premium Quality You Can Trust: Selerb’s NADGENIE is made in the USA with globally sourced, non-GMO ingredients. Free from gluten, soy, dairy, and artificial additives. Third-party tested for purity and potency, this clean NAD+ supplement for men is crafted to support energy and wellness—naturally.
Selerb combines NAD+ boosters with resveratrol and nitric oxide support specifically formulated to address men’s prostate health, cellular energy, and cardiovascular function.
This comprehensive formula targets multiple aspects of men’s aging with NAD+ precursors that support cellular energy production and DNA repair, resveratrol for its longevity-promoting properties, and nitric oxide boosters for cardiovascular and prostate health. The combination addresses both visible signs of aging and underlying cellular health, making it an excellent all-in-one solution for men focused on healthy aging.
What We Like
- Targets prostate health along with cellular aging
- NAD+ support enhances energy and recovery
- Includes cardiovascular-supporting ingredients
What Could Be Better
- Premium pricing
- Effects may take several weeks to notice
Bottom Line: A comprehensive anti-aging formula specifically designed for men’s unique health needs.
2. Sugar Free Multivitamin for Men 50 Plus — Best Value
- SPECIALLY FORMULATED FOR MEN 50+：Give the nutrients your body needs with 2 gummies at breakfast. This mens multivitamins 50 plus formula delivers 30+ highly bioavailable nutrients - methylated B vitamins, plant based D3, vitamins A, C, E, K2 and key minerals calcium, magnesium, zinc, etc. Enhanced with energy-boosting herbal blend & CoQ10, immune-boosting elderberry, mobility-promoting turmeric,gut-friendly digestive enzyme. Designed to fill nutritional gaps and support men’s vitality after 50.
- BOOST ENERGY & IMMUNE DEFENSE NATURALLY：Fuel your busy work and family time with methylated B vitamins featuring superior absorption for sustained energy and CoQ10 to enhance stamina. Our men's multivitamin 50 plus also contain Energy Blend (Ashwagandha, Ginseng, Maca & Rhodiola) to boost energy levels naturally. Vitamin C, selenium and elderberry help shield against seasonal threats year-round and boost immunity during cold and flu season-ideal for men's 50+ with active and busy lifestyles.
- SUOOPRT KEY AREAS OF MEN'S 50+ HEALTH: This mens vitamins multivitamin 50 plus formula is a holistic approach to aging well. Digestive enzymes aid gut health, while Omega-3 + K2 support pulsates with Vitality. Turmeric + Calcium + D3 promote mobility for post-workout recovery; Magnesium and Methylfolate support sharper thinking for demanding careers. Lycopene + Saw Palmetto + zinc maintain men's physical health. Our multivitamin gummies help men over 50 stay active for life’s important moments.
- ULTRA-ABSORPTION FILLED GUMMIES: Our multivitamin for men over 50 filled gummies keep sensitive nutrients like vitamins and minerals in the core, while outer pectin layer protects them from degradation, ensuring 5X ABSORPTION RATE than regular gummies.These multivitamin gummies deliver delicious MIXED BERRY FLAVOR and rich texture, sweetened with MONK FRUIT for SUGAR-FREE, made with vegan pectin and easy to chew. Great for travel, busy schedules, or seniors who prefer an alternative to pills!
- TRUSTED QUALITY：Our mens 50 plus multivitamin gummies are formulated WITHOUT artificial flavors, synthetic colors, or preservatives. Made with non-GMO, gluten-free, and gelatin-free ingredients, each gummy is rigorously lab-tested by independent third parties to verify purity and potency—ensuring NO BURDENS on your body. We are committed to delivering a product of premium quality. If you have any concerns, we’re here to help—contact us anytime！
This sugar-free gummy multivitamin delivers methylated B vitamins, omega-3, CoQ10, and elderberry specifically formulated for men over 50.
Designed for aging men, this formula provides essential nutrients in their most bioavailable forms. Methylated B vitamins ensure optimal absorption even if you have MTHFR gene variants, while CoQ10 supports heart health and cellular energy. Omega-3 fatty acids promote cardiovascular and brain health, and elderberry provides immune support—all in a convenient, great-tasting gummy.
What We Like
- Sugar-free formula ideal for men watching their intake
- Methylated vitamins for superior absorption
- Gummy form is easy and enjoyable to take
What Could Be Better
- May not provide therapeutic doses of all ingredients
- Requires refrigeration after opening
Bottom Line: An excellent daily foundation for men over 50 at an affordable price point.
3. PS Longevity Multivitamin — Best Premium
- BASIC BUILDING BLOCK OF LONGEVITY: 90% of Americans don't get enough anti-aging antioxidants every day. Bridge your antioxidant gap with our revolutionary multivitamin. It features just the right amount of the most bioavailable forms of every ingredient, including methylated B12, methylated Folate, and methylated B6, ensuring optimal absorption and utilization by the body.
- COMPREHENSIVE NUTRIENT PROFILE: Packed with 27 vital nutrients such as Urolithin A (from pomegranate), CoQ10, Resveratrol, Nicotinamide Riboside Chloride (NR, an NAD+ precursor), Choline, Alpha-Lipoic Acid (ALA), Lutein, Zeaxanthin and Vitamin K2, this supplement supports overall health and well-being to help you stick around for the long haul.
- POTENT ANTIOXIDANT SUPPORT: Enriched with powerful antioxidants and polyphenols, our formula based on decades of clinical studies helps combat oxidative stress, promoting cellular rejuvenation and vitality.
- AN MTHFR SUPPLEMENT FOR EVERYONE: Designed to meet the unique nutritional needs of both men and women, our one-of-a-kind longevity supplement supports heart health, cognitive function, metabolic health, and more.
- THE PS PROMISE: We created a gluten free, vegan, GMO-free MTHFR multivitamin that we are actually excited to take. From a glass bottle to minimize microplastics, forever chemicals (PFAS), BPA and Phthalates to 3rd party testing (UL laboratories) to ensure the formula on the bottle is the formula you get– we pulled out all the stops so we could grow young together.
This cutting-edge longevity supplement packs 27 vital nutrients including urolithin A, CoQ10, resveratrol, and nicotinamide riboside for comprehensive cellular health support.
PS Longevity represents the latest in anti-aging science, combining traditional vitamins and minerals with advanced longevity compounds. Urolithin A supports mitochondrial health and cellular cleanup, NR boosts NAD+ levels for energy and DNA repair, and CoQ10 promotes cardiovascular function. The methylated B vitamin complex ensures optimal absorption, while antioxidants like resveratrol and alpha-lipoic acid combat oxidative stress.
What We Like
- 27 research-backed anti-aging nutrients
- Glass bottle minimizes microplastic exposure
- Formulated for both men and women’s longevity needs
What Could Be Better
- Higher price point than basic multivitamins
- Multiple capsules daily
Bottom Line: A premium, science-based longevity supplement for men serious about comprehensive anti-aging.
4. Beet Root Gummies with CoQ10
- Energy-Supporting Beet Root Gummies - Each gummy delivers 500mg beet root, supporting energy levels and endurance, ideal for men and women seeking a convenient performance support.
- Nitric Oxide Support - Our gummies are formulated with beet root and CoQ10 to support nitric oxide production, helping to elevate endurance and recovery during daily activities.
- Advanced Formula with Pomegranate & Grape Seed Extract - This antioxidant-rich blend supports overall wellness and aids in recovery, helping you maintain peak performance.
- Convenient & Flavorful - Enjoy the benefits of beet root in a delicious mixed berry gummy, offering an easy and tasty way to support energy and endurance without the need for beet juice or powder.
- Vegan & Non-GMO Gummies - Our beet root gummies are crafted for those with dietary preferences, providing a vegan, gluten-free option to support energy and endurance effectively.
These gummies combine beetroot extract with CoQ10 and pomegranate to boost nitric oxide production for enhanced circulation and cardiovascular health.
Nitric oxide production declines with age, affecting blood flow, exercise performance, and cardiovascular health. Beetroot is rich in nitrates that convert to nitric oxide, supporting healthy blood pressure and circulation. CoQ10 enhances cellular energy production in heart tissue, while pomegranate provides additional antioxidant support for cardiovascular aging.
What We Like
- Supports nitric oxide for improved circulation
- CoQ10 benefits heart health and energy
- Tasty gummy form improves compliance
What Could Be Better
- Contains some sugar
- Lower doses than some powder supplements
Bottom Line: An excellent choice for men focused on cardiovascular health and exercise performance.
5. High Strength Hawthorn Berry Capsules
- SUPPORT YOUR HEALTHY HEART – Our high-potency hawthorne berry supplement is designed to promote cardiovascular health, circulation & healthy heart support. This powerful formula contains a concentrated 4:1 extract of hawthorne berry, hawthorn leaves & flower to maximize its supporting benefits.
- PROMOTES HEALTHY HEART & CIRCULATION HEALTH – Rich in natural antioxidants, flavonoids, and bioactive compounds, our hawthorn berry extract helps maintain healthy blood pressure & supports arterial function. It has been traditionally used to promote circulation & strengthen overall health.
- POTENT HERBAL BLEND – Our advanced formula contains a potent combination of hawthorne berry extract, hawthorn leaf & flower extract, delivering essential flavonoids like Quercetin, Rutin, Apigenin, and Myricetin. These compounds support cardiovascular function & combat oxidative stress.
- HOW TO USE & IMPORTANT WARNINGS – Take the recommended serving daily of hawthorne berry capsules with water or as advised by your doctor. Consult your doctor before use if you are pregnant, nursing, taking medication, or have a medical condition to avoid interactions.
- MADE IN THE USA WITH GLOBALLY SOURCED INGREDIENTS – Our hawthorn extract supplement is manufactured in a GMP-compliant facility and undergoes rigorous third-party testing for quality, purity & potency. We prioritize clean ingredients, providing a product free from artificial additives, fillers & preservatives.
This pure hawthorn supplement includes berry, leaf, and flower for comprehensive cardiovascular support and antioxidant protection.
Hawthorn has been used for centuries to support heart health and is particularly beneficial for aging men concerned about cardiovascular function. The complete plant extract provides flavonoids and oligomeric procyanidins that support healthy blood pressure, improve circulation, and protect blood vessels. This is especially important as cardiovascular disease risk increases with age in men.
What We Like
- Complete hawthorn plant extract for maximum benefits
- Strong antioxidant support for heart health
- High-quality, pure formulation
What Could Be Better
- May interact with heart medications
- Effects develop gradually over weeks
Bottom Line: A traditional cardiovascular tonic ideal for aging men’s heart health.
6. Juvenon Cellular Health
- Cellular Defense: Juvenon helps protect your healthspan by supporting cellular function and resilience. Our formula promotes optimal cellular function by providing essential nutrients like Acetyl L-Carnitine and Biotin, which play key roles in cellular energy production and repair processes.
- Scientific Innovation: With many years of scientific research, Juvenon's formula harnesses the power of Acetyl L-Carnitine and Biotin to support healthy aging. Acetyl L-Carnitine and Biotin work synergistically to promote cellular health and vitality.
- Positive Effects: Many satisfied customers have reported improvements in overall health and well-being with daily use of NAD+ products. While individual experiences may vary, consistent use of Juvenon can support your body's natural processes and promote a healthy aging process.
- TRUSTED & RELIABLE: Completely natural, soy and dairy-free supplement contains no artificial fillers, colors, or preservatives. Nootropic supplement may help promote better focus, clarity, mental energy, and support for a healthier and improved mood.
- Scientifically Validated: With consistent daily use, NAD+ (nicotinamide adenine dinucleotide) is backed by extensive scientific research, with numerous studies demonstrating its crucial role in cellular energy metabolism, DNA repair, and overall cellular health.
Juvenon combines acetyl L-carnitine with biotin to support NAD+ production, cellular energy, and heart and brain health.
Acetyl L-carnitine plays a crucial role in mitochondrial function and energy production, both of which decline with age. This formula supports NAD+ levels naturally while also providing benefits for cognitive function and cardiovascular health. Biotin supports healthy metabolism and cellular function, making this an excellent choice for men focused on maintaining mental sharpness and physical energy.
What We Like
- Supports NAD+ for cellular energy
- Benefits both heart and brain health
- Well-researched ingredients
What Could Be Better
- Tablet form may be less convenient
- Some users prefer comprehensive formulas
Bottom Line: A focused cellular health supplement for men prioritizing energy and cognitive function.
7. Quercetin + Nettle Supplement
- Immune & Inflammatory Response Support - This formula delivers 600mg of Quercetin plus 600mg of Nettles in each serving. These two plant extracts have been shown to help the immune system, and the body's natural response to environmental challenges.*
- Why Quercetin? Quercetin has been called the king of flavonoids supplements, because of its powerful antioxidant properties. It helps the body regulate histamine.*
- Why Nettles? Nettle leaf has a high vitamin C content underlying its immune-supportive and antioxidant properties that may also benefit a normal inflammatory response.*
- Vegan & Non-GMO - These Nettle + Quercetin supplements are vegetarian and vegan-friendly. Made without GMOs, gluten, dairy, soy.*
- Over 50,000 Doctors Agree - Designs for Health is the physician's choice for top quality professional strength supplements since 1989. Our "Science First" philosophy ensures our Quercetin + Nettle supplement is based on the most recent research and use the highest quality raw ingredients.
This professional-grade formula combines quercetin with nettle leaf for powerful senolytic and anti-inflammatory benefits.
Quercetin is a senolytic compound that helps clear out damaged “zombie” cells that accumulate with age and drive inflammation. Combined with nettle’s anti-inflammatory properties, this supplement supports healthy aging at the cellular level while also providing benefits for prostate health—a key concern for aging men. The flavonoid content also supports cardiovascular health.
What We Like
- Quercetin targets cellular senescence
- Nettle supports prostate health
- Professional-grade formulation
What Could Be Better
- Premium pricing
- May cause mild digestive effects initially
Bottom Line: An excellent senolytic supplement with added benefits for men’s prostate health.
8. Quercetin 500mg High Strength
- Precision Dosage: Our quercetin supplements are made with a high potency 500mg serving from quercetin dihydrate powder known for offering superior bioavailability so you get more out of every capsule
- Why Dihydrate: We developed our supplements with this form thanks to its better absorption and potency provided from the 2 water molecules maximizing the antioxidant and immunity support benefits
- The Clear Difference: At Clear Formulas we believe transparency and trust are essential which is why our product is made in an FDA inspected American facility according to strict regulatory guidelines
- Made for All in Mind: We stand by our name and our formula is made without many common allergens and additives including corn, dairy, gluten, salt, soy, wheat or artificial preservatives
- The Choice is Clear: We believe health doesn't have to be hard - We make it simple with carefully designed supplements to support your needs whatever your age and lifestyle we've got you covered
This high-potency quercetin supplement delivers 500mg per capsule for powerful antioxidant and cellular cleanup benefits.
At 500mg per capsule, this formula provides therapeutic doses of quercetin dihydrate for senolytic effects. Regular use helps reduce the burden of senescent cells that contribute to age-related inflammation and tissue damage. Quercetin also supports cardiovascular health, immune function, and exercise recovery—all important for maintaining vitality as you age.
What We Like
- High 500mg therapeutic dose
- Quercetin dihydrate form for absorption
- Excellent value with 120 capsules
What Could Be Better
- Best taken with food
- Some may prefer combination formulas
Bottom Line: A powerful stand-alone senolytic for men focused on cellular health.
9. AEON Liposomal NAD+ Longevity Complex
- MULTI-TARGETED FORMULA FOR MODERN WELLNESS: AEON combines Nicotinamide, Fisetin, Quercetin, Resveratrol, Astragalus, TMG, EGCG, Riboflavin, L-Theanine, and vitamins B6 and B12—ingredients thoughtfully selected to support your daily vitality and overall balance. This supplement is designed to work in harmony with your routine.
- SIMPLIFY YOUR WELLNESS ROUTINE: Whether you're starting a busy day or winding down in the evening, AEON fits seamlessly into your lifestyle. With a clean blend of 11 carefully chosen ingredients, it’s an easy and intentional step toward staying consistent and aligned with your personal health goals—no matter your pace.
- SUPPORT FOR SKIN, IMMUNE FUNCTION & MORE: Perpetua Life’s AEON Longevity Complex formula features a blend of 11 carefully selected ingredients designed to support healthy-looking skin, immune function, and overall wellness. This thoughtfully formulated supplement may help you maintain balance and vitality as part of your daily routine.
- CLEAN, EASY-TO-TAKE CAPSULES: AEON is designed for convenience. These smooth, vegan flavor-neutral capsules contain no artificial additives or unnecessary fillers. Gluten free and travel-friendly, they’re made to integrate effortlessly into your routine—just take with water and go.
- BUILD YOUR WELLNESS STACK WITH PERPETUA LIFE: AEON is just the beginning. Explore other supplements in the Perpetua Life collection, each crafted to support different aspects of your life. Mix, match, and create a daily routine that fits your needs, powered by clean, plant-forward formulas.
AEON combines 11 carefully selected longevity ingredients including NAD+, nicotinamide riboside, resveratrol, quercetin, and fisetin in liposomal form for enhanced absorption.
This comprehensive formula uses liposomal technology to improve the bioavailability of key anti-aging compounds. NAD+ and NR support cellular energy and DNA repair, resveratrol activates longevity genes, and senolytic compounds like quercetin and fisetin help clear damaged cells. The addition of TMG, EGCG, and astragalus provides additional metabolic and immune support.
What We Like
- 11 synergistic anti-aging ingredients
- Liposomal delivery enhances absorption
- Vegan, clean formulation
What Could Be Better
- Higher price point
- Complex formula may not suit everyone
Bottom Line: A comprehensive liposomal longevity formula for men seeking advanced anti-aging support.
10. NOVOS Core Longevity Mix
- KEY BENEFITS: NOVOS Core targets the 12 root biological causes of aging simultaneously at the cellular level by using an evidence-backed formulation of ingredients based on the latest longevity science. Each sachet contains 6.9 grams of proprietary, patent-pending, blend of 12 comprehensively studied lifespan and health span ingredients to slow down the pace of aging and improve your skin health, energy, brain cognition, and mood.
- SCIENTIFICALLY-BACKED: NOVOS Core is the first, most studied, and scientifically validated solution that leverages 12 longevity ingredients into one powerful mix. Our product is formulated by our team of the world's best longevity scientists and medical doctors from Harvard Medical School, MIT, and other top institutions. NOVOS Core's efficacy is backed by over 400+ studies in independent 3rd party research studies. NOVOS Core is 3rd party tested and manufactured in the USA.
- SKIN SUPPORT: NOVOS Core contains key longevity ingredients like hyaluronic acid, alpha-ketoglutarate, glycine, vitamin C, and glucosamine, known to improve skin health. Hyaluronic acid enhances hydration and reduces wrinkles, while alpha-ketoglutarate boosts collagen production and supports skin stem cell health. Glycine and glucosamine help strengthen the skin’s extracellular matrix, improving skin health and supporting healthy aging
- NATURE-BASED: The ingredients we choose are found in food or human biology, and contains high-quality ingredients at the optimal dosages including magnesium, vitamin C, ginger, hyaluronic acid, L-Theanine, glycine, rhodiola rosea, fisetin, glucosamine sulfate, pterostilbene, calcium alpha-ketoglutarate, and magnesium malate to tackle multiple mechanisms of aging. NOVOS Core contains zero calories and sugar, is all-natural, vegan, and gluten-free, 3rd party tested and manufactured in the USA.
- RECOMMENDED USE: Add 1 sachet of powder to water, juice, smoothie, yogurt, tea or drink of choice, preferably with or after a meal. You may take up to two sachets per day as part of your daily routine. Each box contains 30 servings for a one-month supply.
NOVOS Core targets 12 root biological causes of aging with a scientifically validated blend of longevity ingredients developed by Harvard and MIT scientists.
This powder supplement contains 12 comprehensively studied ingredients at research-backed doses to slow aging at the cellular level. Key components include hyaluronic acid, alpha-ketoglutarate, glycine, vitamin C, glucosamine, magnesium, ginger, L-theanine, rhodiola, fisetin, pterostilbene, and calcium alpha-ketoglutarate. The formula supports energy, cognition, mood, and cellular health.
What We Like
- 12 research-backed longevity ingredients
- Developed by leading longevity scientists
- Convenient single-serve sachets
What Could Be Better
- Premium pricing
- Requires mixing with liquid
Bottom Line: A cutting-edge, science-based longevity formula for men who want comprehensive anti-aging support.
How to Choose the Best Anti-Aging Supplement for Men
When selecting an anti-aging supplement, first identify your primary health concerns. Men typically need to focus on cardiovascular health, prostate function, muscle mass maintenance, and testosterone optimization as they age. If you’re primarily concerned about heart health and circulation, look for supplements containing CoQ10, beetroot extract, hawthorn, or omega-3 fatty acids. For prostate health, consider formulas with quercetin, nettle, or saw palmetto.
Evaluate the ingredient quality and dosing. Key anti-aging compounds for men include NAD+ boosters like NMN or nicotinamide riboside (250-500mg), resveratrol (100-500mg), CoQ10 (100-200mg), and senolytic compounds like quercetin (500mg) and fisetin (100mg). Methylated B vitamins are important, especially if you have MTHFR gene variants that affect nutrient metabolism. Check that the supplement provides therapeutic doses of active ingredients rather than just trace amounts.
Consider whether you want a targeted approach or comprehensive formula. Single-ingredient supplements like high-dose quercetin or CoQ10 allow you to customize your regimen based on specific needs and stack strategically. Comprehensive longevity formulas like PS Longevity or NOVOS Core provide multiple anti-aging pathways in one product, which can be more convenient and cost-effective than buying several individual supplements.
Form and convenience matter for long-term compliance. Capsules are convenient and tasteless, powders often provide higher doses and can be added to drinks or smoothies, and gummies offer an enjoyable taste but may contain some sugar. Choose a form you’ll actually take consistently. Also consider third-party testing, manufacturing standards, and whether the company provides transparency about sourcing and testing. Always consult your healthcare provider before starting new supplements, especially if you have underlying health conditions or take medications.
Benefits of Anti-Aging Supplements for Men
Anti-aging supplements support men’s health at multiple levels. Cellular health compounds like NAD+ boosters (NMN, NR) enhance mitochondrial function, which naturally declines with age. This supports energy production, DNA repair, and metabolic function. Studies show NAD+ levels drop significantly after age 40, contributing to fatigue, reduced recovery, and accelerated aging. Supplementation helps restore these levels, potentially improving physical performance and cellular resilience.
Cardiovascular support is crucial for men’s longevity, as heart disease remains the leading cause of death. Supplements like CoQ10, omega-3 fatty acids, and beetroot extract support healthy blood pressure, improve circulation, and protect blood vessels. CoQ10 is particularly important for men on statin medications, as these drugs deplete natural CoQ10 levels. Nitric oxide boosters from beetroot and citrulline support healthy blood flow, benefiting both cardiovascular health and exercise performance.
Senolytic compounds like quercetin and fisetin help clear senescent cells that accumulate with age and drive inflammation. These “zombie cells” contribute to tissue damage, chronic inflammation, and age-related diseases. By supporting the body’s natural cleanup processes, senolytics may help reduce inflammation markers and promote healthier aging. Research in this area is emerging, with promising results for tissue function and healthspan.
For men specifically, many anti-aging supplements support testosterone levels, prostate health, and muscle maintenance. Ingredients like nettle, saw palmetto, and zinc support prostate function, while compounds like vitamin D, magnesium, and amino acids help maintain healthy testosterone levels. Maintaining muscle mass and strength is critical for men’s health and independence as they age, and supplements supporting protein synthesis and recovery can help preserve these functions alongside proper exercise and nutrition.
Frequently Asked Questions
What are the best anti-aging supplements for men over 50?
Men over 50 benefit most from comprehensive formulas that address cardiovascular health, cellular aging, and prostate support. Key ingredients include CoQ10 for heart health, NAD+ boosters like NMN or NR for cellular energy, quercetin for senolytic benefits, vitamin D for bone and immune health, and omega-3 fatty acids for cardiovascular and brain function. Formulas like PS Longevity or targeted combinations of CoQ10, resveratrol, and quercetin provide solid foundations for men in this age group.
Can anti-aging supplements help with testosterone levels?
While specialized testosterone boosters exist, some anti-aging supplements indirectly support healthy testosterone levels. Vitamin D deficiency is linked to low testosterone, so maintaining optimal levels is important. Magnesium and zinc also support testosterone production. NAD+ boosters may help maintain cellular function in testosterone-producing tissues. However, for clinically low testosterone, medical treatment is more appropriate than supplementation alone. Anti-aging supplements work best as part of an overall health strategy including strength training, adequate sleep, and stress management.
How do NAD+ boosters work for anti-aging?
NAD+ (nicotinamide adenine dinucleotide) is a crucial coenzyme that declines significantly with age, dropping by 50% or more by age 50. NAD+ is essential for cellular energy production, DNA repair, and activating sirtuins—proteins associated with longevity. Supplements containing NMN (nicotinamide mononucleotide) or NR (nicotinamide riboside) are precursors that your body converts to NAD+. Research suggests these supplements can increase NAD+ levels, potentially improving energy, cognitive function, metabolic health, and cellular resilience. Effects typically become noticeable within 2-4 weeks of consistent use.
Are senolytic supplements safe for men?
Senolytic supplements like quercetin and fisetin are generally safe when taken at recommended doses. Quercetin at 500mg daily and fisetin at 100mg are well-tolerated by most people. Some practitioners recommend intermittent dosing (a few days per month) rather than daily use for senolytics, though research on optimal protocols is still emerging. These supplements may interact with blood thinners and certain medications, so consult your healthcare provider if you’re on medications. Men with cancer or cancer history should discuss senolytic use with their oncologist, as effects on cancer cells are still being studied.
Should I take collagen supplements as a man?
While collagen is often marketed to women for skin benefits, men can also benefit from collagen supplementation. Collagen supports joint health, which is crucial for maintaining an active lifestyle as you age. It also benefits skin elasticity, wound healing, and gut health. Men engaged in strength training or sports may find collagen helpful for connective tissue support and recovery. Typical doses range from 10-20 grams daily. While it’s less commonly included in men’s anti-aging formulas compared to women’s, it can be a valuable addition, especially for joint health and athletic performance.
How long before I see results from anti-aging supplements?
Timeline varies by supplement type and what you’re measuring. NAD+ boosters may increase energy levels within 2-4 weeks. CoQ10 for heart health typically requires 4-8 weeks of consistent use. Senolytic effects on inflammation markers may take 2-3 months to become measurable. Cardiovascular improvements from beetroot or hawthorn often show in 6-12 weeks. Long-term cellular benefits may not be “felt” but can be measured through blood markers, biological age testing, or sustained vitality over years. Commit to at least 3 months of consistent use before evaluating effectiveness.
Can I combine multiple anti-aging supplements?
Yes, many anti-aging supplements work synergistically and can be safely combined. Common beneficial pairings include NAD+ boosters with resveratrol, CoQ10 with omega-3s, and quercetin with fisetin. However, avoid redundancy—taking multiple NAD+ boosters simultaneously typically isn’t necessary. When combining supplements, ensure you’re not exceeding safe upper limits for individual nutrients and watch for interactions. Comprehensive formulas like NOVOS Core or PS Longevity already combine multiple ingredients intelligently, which can be more cost-effective than buying each separately. Always consult your healthcare provider when building a supplement regimen.
Do anti-aging supplements interact with medications?
Some anti-aging supplements can interact with medications. Quercetin may interact with blood thinners and certain antibiotics. CoQ10 can affect blood thinning medication and blood pressure drugs. Resveratrol may also affect blood clotting and interact with some medications. Always inform your healthcare provider about all supplements you’re taking, especially if you’re on blood thinners, blood pressure medications, diabetes drugs, or medications for heart conditions. Your doctor or pharmacist can help identify potential interactions and adjust dosing if needed.
