Best Apigenin Supplements

Apigenin, a powerful flavonoid found naturally in chamomile, parsley, and celery, has gained significant attention for its potential benefits in promoting relaxation, supporting sleep quality, and providing neuroprotective effects.

If you’re struggling with sleep issues, looking for natural stress support, or interested in the longevity benefits of senolytics, apigenin supplements offer a research-backed option without the grogginess associated with traditional sleep aids. We’ve researched the best apigenin supplements available to help you find a high-quality option that delivers real results.

Our Top Picks at a Glance

• Best Overall: Double Wood Supplements Apigenin 50mg
• Best Value: Swanson Apigenin Supplement 50mg
• Best High Potency: BOSCENT Apigenin 100mg
• Best with L-Theanine: Native Nature Apigenin with L-Theanine
• Best Liposomal: Codeage Liposomal Apigenin
• Best Long Supply: LongLifeNutri Apigenin 100mg
• Best Budget High-Dose: DEAL SUPPLEMENT Apigenin 100mg

Detailed Comparison Table

Product	Potency	Count	Supply Duration	Price Range	Rating
Double Wood 50mg	50mg	120 capsules	2 months	$$	4.5/5
Swanson 50mg	50mg	90 capsules	3 months	$	4.4/5
BOSCENT 100mg	100mg	120 capsules	4 months	$$	4.5/5
Native Nature w/ L-Theanine	100mg + 400mg	120 capsules	4 months	$$	4.6/5
Codeage Liposomal	500mg	90 softgels	3 months	$$$	4.3/5
LongLifeNutri 100mg	100mg	180 capsules	6 months	$$	4.5/5
DEAL 100mg	100mg	180 capsules	3 months	$	4.4/5

Detailed Product Reviews

1. Double Wood Supplements Apigenin 50mg – Best Overall

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Double Wood Supplements has built a strong reputation for quality nootropics and longevity supplements, and their apigenin offering maintains those high standards. This chamomile-derived formula provides a moderate 50mg dose that balances effectiveness with flexibility for dosing adjustments.

What We Like:

• 50mg per capsule allows flexible dosing from 50-150mg based on needs
• Extracted from chamomile flowers for high-quality natural source
• Supports relaxation and sleep without next-day grogginess
• May support healthy cortisol levels and stress response
• Third-party tested for purity and potency
• 120 capsules provide full 2-month supply at standard dose
• Manufactured in USA to high quality standards
• Gluten-free and suitable for most dietary restrictions

What Could Be Better:

• Higher price per serving compared to some alternatives
• Lower dose means taking multiple capsules for higher amounts
• Some users may not notice effects for several days

Bottom Line: Double Wood’s apigenin supplement delivers consistent quality backed by rigorous testing and manufacturing standards. The 50mg dose provides excellent flexibility whether you’re starting with lower amounts or need to adjust based on response. While not the cheapest option, the quality control and reliability justify the investment for those serious about using apigenin for sleep and relaxation support.

2. Swanson Apigenin Supplement 50mg – Best Value

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Swanson brings decades of supplement industry experience to their apigenin offering. Derived from celery rather than chamomile, this formula provides an alternative plant source while maintaining effectiveness at a budget-friendly price point.

What We Like:

• Excellent value at one of the lowest per-serving costs
• Derived from celery as a natural and familiar plant source
• Supports restful sleep and stress relief at cellular level
• May support men’s prostate health as additional benefit
• Provides antioxidant support for cellular health
• 90 capsules offer full 3-month supply at one per day
• Trusted Swanson brand with long industry track record
• Manufactured to highest quality standards

What Could Be Better:

• Contains gelatin so not suitable for vegetarians or vegans
• 50mg dose may be modest for some users’ needs
• Celery-derived may concern those with celery allergies

Bottom Line: Swanson delivers solid apigenin supplementation at an attractive price that makes long-term use affordable. While the gelatin capsules limit suitability for some dietary preferences, the quality and value make this an excellent choice for budget-conscious consumers. The celery source provides confidence in natural extraction and the modest 50mg dose works well for beginners or those seeking gentle sleep support.

3. BOSCENT Apigenin 100mg – Best High Potency

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For those seeking higher doses of apigenin in fewer capsules, BOSCENT offers a potent 100mg formulation with impressive 98% purity. This concentrated formula provides strong support for sleep, mood, and cognitive function in a convenient single-capsule dose.

What We Like:

• 100mg per capsule provides higher potency in single dose
• 98% purity ensures you’re getting concentrated active compound
• Supports restful sleep by helping balance cortisol levels
• May support brain health and cognitive function
• Provides prostate health support as additional benefit
• 120 capsules offer impressive 4-month supply
• Made in USA in GMP-certified facility
• Vegan capsules suitable for plant-based diets

What Could Be Better:

• Higher dose may be more than beginners need initially
• Cannot fine-tune dosing as easily as 50mg options
• Some users may find 100mg too relaxing for daytime use

Bottom Line: BOSCENT’s high-purity, high-potency apigenin appeals to experienced supplement users who know they respond well to higher doses. The 100mg capsules simplify your routine while the 4-month supply provides excellent value. The vegan formulation and GMP certification add confidence in quality. If you’re new to apigenin, starting with a lower dose might be wise, but for established users, this potent option delivers strong results.

4. Native Nature Apigenin with L-Theanine – Best with L-Theanine

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Native Nature combines 100mg apigenin with 400mg L-theanine in a synergistic formula that maximizes relaxation and sleep support. This thoughtful combination addresses stress and sleep from multiple pathways, providing comprehensive evening support.

What We Like:

• Synergistic combination of apigenin and L-theanine enhances effects
• 100mg apigenin from chamomile + 400mg L-theanine from green tea
• Dual-action approach promotes both relaxation and sleep quality
• May support mood, energy, and hormonal balance throughout day
• Helps promote calm without sedation or grogginess
• NON-GMO and free from soy, gluten, fillers, and artificial ingredients
• 120 vegan capsules provide 4-month supply
• Third-party tested for purity and quality

What Could Be Better:

• Combination formula limits ability to adjust individual compounds
• Higher price reflects premium multi-ingredient formulation
• L-theanine may not be needed by all apigenin users

Bottom Line: Native Nature’s combination formula represents cutting-edge understanding of sleep and relaxation support. The pairing of apigenin and L-theanine creates synergistic effects greater than either compound alone. While the fixed ratio means less dosing flexibility, the thoughtfully chosen amounts work well for most people. Ideal for those seeking comprehensive stress and sleep support in a single supplement rather than managing multiple bottles.

5. Codeage Liposomal Apigenin – Best Liposomal

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Codeage applies advanced liposomal technology to apigenin supplementation, potentially enhancing absorption and bioavailability. This sophisticated delivery system may provide superior results for those who haven’t responded well to standard apigenin formulations.

What We Like:

• Liposomal delivery system may enhance absorption significantly
• Includes complementary compounds like fisetin and quercetin
• Phospholipid complex from non-GMO sunflower oil
• May provide more consistent blood levels throughout day
• Softgel format often more pleasant to take than capsules
• 90 softgels provide 3-month supply
• Vegan-friendly despite softgel format
• Gluten-free formulation

What Could Be Better:

• Significantly higher price reflects advanced technology
• Limited research on liposomal apigenin specifically
• Additional compounds may not be needed by everyone

Bottom Line: Codeage’s liposomal apigenin represents the premium end of the market, using advanced delivery technology that may benefit those seeking maximum absorption. The inclusion of complementary flavonoids creates a comprehensive antioxidant formula. While expensive, the enhanced bioavailability may mean you need less to achieve results, potentially justifying the cost for those who value cutting-edge supplement technology.

6. LongLifeNutri Apigenin 100mg – Best Long Supply

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LongLifeNutri provides an impressive 6-month supply of high-quality apigenin at a competitive price. This family-owned company focuses on creating trustworthy supplements with premium ingredients and rigorous quality control.

What We Like:

• 180 capsules provide full 6-month supply for convenience
• 100mg per serving delivers effective dose in single capsule
• High-purity bioflavonoid sourced from chamomile extract
• Supports relaxation and recovery routines naturally
• Vegetarian capsules suitable for plant-based diets
• Made in USA in GMP-certified facility
• Free from GMOs, gluten, and artificial fillers
• Includes free premium pill organizer with purchase

What Could Be Better:

• Large bottle size may be less convenient for travel
• Six-month supply requires confidence in the product
• Single 100mg dose limits fine-tuning flexibility

Bottom Line: LongLifeNutri’s generous 6-month supply offers excellent convenience and value for committed apigenin users. The 100mg dose hits the sweet spot for most people seeking sleep and relaxation support, while the vegetarian capsules and clean formulation ensure broad suitability. The family-owned company’s commitment to quality and the included pill organizer demonstrate attention to customer experience beyond just the supplement itself.

7. DEAL SUPPLEMENT Apigenin 100mg – Best Budget High-Dose

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DEAL SUPPLEMENT provides high-potency apigenin at an attractive price point. With 180 capsules of 100mg each, this option delivers a 3-month supply (at recommended 2-capsule serving) of concentrated chamomile extract.

What We Like:

• 180 concentrated capsules offer excellent value
• High-potency 100mg serving from pure chamomile extract
• Highly purified and third-party lab tested
• Non-GMO formulation without common allergens
• Free from gluten, dairy, eggs, peanuts, soy, wheat, and tree nuts
• Supports natural relaxation and better sleep quality
• Budget-friendly pricing makes long-term use affordable
• Generous supply reduces need for frequent reordering

What Could Be Better:

• Less established brand than some competitors
• Fewer customer reviews than major brands
• Capsule material not specified as vegetarian

Bottom Line: DEAL SUPPLEMENT offers strong value for budget-conscious consumers who want high-potency apigenin without premium pricing. The third-party testing and allergen-free formulation provide quality assurance despite the lower price. While the brand lacks the track record of established names, the impressive supply and testing credentials make this a worthwhile option for those prioritizing affordability.

What Is Apigenin?

Apigenin is a naturally occurring flavonoid – a class of plant compounds with antioxidant and anti-inflammatory properties – found abundantly in chamomile, parsley, celery, and various other plants. Chamomile tea owes much of its calming effect to apigenin content, which has been used for centuries as a natural relaxation aid. The compound belongs to the flavone subclass of flavonoids and has gained scientific attention for its wide-ranging biological activities.

Unlike many plant compounds that are poorly absorbed, apigenin demonstrates reasonable bioavailability when taken as a supplement, particularly when consumed with some dietary fat. Research suggests apigenin works through multiple mechanisms: it binds to benzodiazepine receptors in the brain (similar to anti-anxiety medications but much gentler), exhibits potent antioxidant activity, supports healthy inflammatory responses, and may help regulate cellular processes related to aging.

Recent interest in apigenin has extended beyond traditional uses for relaxation and sleep. The compound shows promise as a senolytic – a substance that may help clear senescent (aged and dysfunctional) cells from the body. This potential has made apigenin popular among longevity enthusiasts and those interested in supporting healthy aging. Additionally, research continues to explore apigenin’s neuroprotective properties and potential benefits for cognitive health.

Benefits of Apigenin Supplements

Promotes Restful Sleep

Apigenin’s most well-known benefit is supporting better sleep quality without the grogginess or dependency issues associated with pharmaceutical sleep aids. The compound binds to GABA-A receptors in the brain, promoting relaxation and making it easier to fall asleep. Unlike melatonin, which primarily affects circadian timing, apigenin works by reducing neural excitation and promoting calm. Most users report falling asleep more easily and waking feeling refreshed rather than sedated.

Reduces Stress and Anxiety

By modulating neurotransmitter activity and supporting healthy cortisol levels, apigenin helps the body manage stress more effectively. The compound’s anxiolytic (anti-anxiety) effects occur without the sedation or cognitive impairment often seen with prescription anti-anxiety medications. Many users report feeling more calm and centered throughout the day when taking apigenin regularly, particularly when combined with other stress-management practices.

Supports Cellular Health and Longevity

Emerging research suggests apigenin may act as a senolytic compound, helping remove dysfunctional senescent cells that accumulate with age and contribute to various age-related conditions. While human studies are still limited, the compound’s ability to induce apoptosis (programmed cell death) specifically in damaged cells while leaving healthy cells unharmed makes it an interesting tool for longevity-focused individuals. The antioxidant properties also protect cells from oxidative stress that accelerates aging.

Neuroprotective Effects

Apigenin demonstrates promising neuroprotective properties through multiple mechanisms. It helps reduce neuroinflammation, protects brain cells from oxidative damage, and may support healthy brain function as we age. Some research suggests apigenin could help maintain cognitive function and potentially reduce risk of neurodegenerative conditions, though more human studies are needed to confirm these effects.

May Support Men’s Health

Some research indicates apigenin may support prostate health and healthy testosterone levels in men. The compound’s anti-inflammatory and antioxidant properties may be particularly relevant for prostate tissue. While not a primary use case, these potential benefits make apigenin attractive for men concerned about maintaining optimal hormonal and urological health as they age.

How to Use Apigenin Supplements

Typical Dosing

Most apigenin supplements provide 50-100mg per capsule, with typical daily doses ranging from 50-200mg depending on individual needs and goals. For sleep support, most people start with 50-100mg taken 30-60 minutes before bedtime. Some users find 50mg sufficient, while others benefit from 100-150mg. For longevity or cellular health purposes, some protocols suggest divided doses throughout the day totaling 200mg or more, though this should be discussed with a healthcare provider.

Timing Considerations

For sleep support, take apigenin 30-60 minutes before your intended bedtime. This allows the compound to begin working as you wind down for the evening. Some users find taking it with a light snack containing fat enhances absorption. If using apigenin for stress management throughout the day, morning or midday dosing may be more appropriate. Consistency matters – taking apigenin at the same time daily helps establish steady blood levels.

Starting Conservatively

Begin with the lower end of the dosing range (50mg) and assess your response before increasing. Some people are quite sensitive to apigenin’s relaxing effects and may find higher doses too sedating. You can always increase the dose after 5-7 days if you’re not experiencing desired effects. This approach minimizes the risk of excessive drowsiness and helps you find your optimal dose.

Combining with Other Compounds

Apigenin combines well with other relaxation-supporting compounds like L-theanine, magnesium, and glycine. Many people create evening “wind-down stacks” that include apigenin along with these complementary nutrients. The compound also pairs well with other senolytics like fisetin and quercetin for those interested in longevity applications. If combining multiple supplements, consider consulting a healthcare provider to ensure appropriate dosing.

Apigenin vs. Other Sleep Supplements

Apigenin vs. Melatonin

Melatonin directly influences your body’s sleep-wake cycle and works best for circadian rhythm issues like jet lag or shift work. Apigenin promotes sleep by reducing neural excitation and promoting calm, making it more suitable for people who struggle to relax at bedtime despite appropriate timing. Melatonin can cause grogginess in some people and may lose effectiveness with regular use, while apigenin typically doesn’t cause next-day sedation. Many people find apigenin more sustainable for long-term nightly use.

Apigenin vs. Magnesium

Magnesium supports sleep through muscle relaxation, nervous system calming, and regulation of neurotransmitters. Apigenin works more specifically on brain receptors that promote calm and reduce anxiety. The two compounds complement each other well and can be taken together for enhanced sleep support. Magnesium provides additional benefits for muscle function, heart health, and hundreds of enzymatic processes, while apigenin offers more targeted sleep and neuroprotective effects.

Apigenin vs. L-Theanine

L-theanine, an amino acid from tea, promotes relaxation without sedation and is often used during the day for focused calm. Apigenin has more pronounced sleep-promoting effects and is typically used in the evening. L-theanine works by influencing GABA, dopamine, and serotonin levels, while apigenin directly binds to benzodiazepine receptors. Many supplements combine both compounds to provide layered support for relaxation and sleep.

Apigenin vs. Valerian Root

Valerian root has traditional use for sleep support but has a strong, unpleasant odor and may cause morning grogginess in some users. Apigenin is odorless and generally doesn’t cause next-day sedation. Valerian’s effects can vary considerably between individuals and products, while apigenin tends to provide more consistent results. Some people respond well to valerian, but apigenin offers a cleaner, more predictable alternative for many.

Who Should Consider Apigenin

People with Sleep Difficulties

If you struggle to fall asleep due to racing thoughts or difficulty relaxing, apigenin may help you wind down more effectively. It’s particularly useful for stress-related insomnia where your mind stays active even though you’re physically tired. Those who dislike melatonin’s effects or want a non-hormonal sleep aid often find apigenin works well for them.

Individuals Seeking Stress Management

People dealing with daily stress and anxiety may benefit from apigenin’s calming effects. While not as immediately powerful as prescription anti-anxiety medications, it provides gentle support for maintaining emotional equilibrium. The lack of side effects and dependency issues makes it attractive for long-term stress management.

Longevity and Health Optimization Enthusiasts

Those interested in emerging longevity research are drawn to apigenin’s potential senolytic properties. While more research is needed, early evidence suggests it may support healthy aging by helping clear dysfunctional cells. People following comprehensive longevity protocols often include apigenin along with other compounds like fisetin, quercetin, and NMN.

Men Concerned About Prostate Health

Men seeking natural support for prostate health may benefit from apigenin’s anti-inflammatory and antioxidant properties. While not a treatment for any condition, it represents a research-backed option for supporting this aspect of men’s health as part of a comprehensive wellness approach.

Potential Side Effects and Considerations

Common Mild Effects

Apigenin is generally well-tolerated with few reported side effects. Some people experience drowsiness, which is actually the desired effect when using it for sleep support. Mild stomach upset can occur, particularly on an empty stomach. Starting with lower doses and taking with food typically resolves any digestive discomfort.

Medication Interactions

Apigenin may interact with certain medications, particularly sedatives, anti-anxiety drugs, and sleep aids, potentially amplifying their effects. If taking prescription medications, consult your healthcare provider before adding apigenin. The compound may also interact with blood thinners due to its effects on platelet aggregation, though clinical significance is unclear.

Not Recommended For

Pregnant or nursing women should avoid apigenin supplements due to insufficient safety data. People with hormone-sensitive conditions should consult healthcare providers, as apigenin may have weak hormonal effects. Those with scheduled surgery should discontinue apigenin at least two weeks prior due to potential bleeding risk.

Tolerance and Dependency

Unlike pharmaceutical sleep aids, apigenin doesn’t appear to cause tolerance or physical dependency with regular use. Most users find it continues working effectively even with nightly use. However, it’s always wise to occasionally assess whether you still need supplementation or if improved sleep habits have made it unnecessary.

Frequently Asked Questions

What is the best time to take apigenin?

For sleep support, take apigenin 30-60 minutes before bedtime. This allows the compound to begin promoting relaxation as you wind down for the evening. Some people find 30 minutes sufficient, while others prefer taking it a full hour before bed. If using apigenin for daytime stress management (less common), morning or midday dosing may be appropriate, though be aware it can cause drowsiness.

How much apigenin should I take for sleep?

Most people find 50-100mg effective for sleep support. Start with 50mg and assess your response for 5-7 days before increasing. Some individuals need up to 150mg for optimal effects, while others find 50mg perfectly adequate. The effective dose varies based on individual sensitivity, body weight, and the severity of sleep difficulties.

Will apigenin make me groggy the next day?

Most people don’t experience next-day grogginess from apigenin, which is a major advantage over many sleep aids. The compound promotes natural sleep without excessive sedation. However, if you take too high a dose or take it too close to wake time, some morning drowsiness may occur. Taking appropriate doses 7-8 hours before waking typically prevents any lingering effects.

Can I take apigenin every night?

Yes, apigenin appears safe for nightly use without building tolerance or causing dependency issues. Many users take it consistently for months or years with continued effectiveness. However, it’s good practice to periodically assess whether you still need supplementation, as improved sleep habits may eventually make it unnecessary.

Is apigenin the same as chamomile tea?

Apigenin is the primary active compound in chamomile tea that provides relaxation benefits, but supplements contain much higher concentrations than tea. A cup of chamomile tea might contain 3-10mg of apigenin, while supplements provide 50-100mg or more. You’d need to drink many cups of tea to match supplement doses, which isn’t practical and would involve excessive liquid intake before bed.

Can I combine apigenin with other sleep supplements?

Yes, apigenin combines well with other sleep-supporting compounds like magnesium, L-theanine, and glycine. These work through different mechanisms and can provide synergistic benefits. However, be cautious about combining with stronger sedatives or prescription sleep medications without consulting your healthcare provider, as effects may be amplified.

Does apigenin help with anxiety during the day?

While apigenin is primarily used for evening relaxation and sleep, some people take it during the day for anxiety management. However, its sedating effects mean you should first assess how it affects you in the evening before considering daytime use. L-theanine might be a better choice for daytime anxiety as it promotes calm without drowsiness.

How long does it take for apigenin to work?

Apigenin’s acute effects on sleep typically appear within 30-60 minutes of ingestion, which is why evening timing matters. However, some users report cumulative benefits developing over several days or weeks of consistent use, particularly for stress management and overall sense of calm. Give any new sleep supplement at least 7-10 days of consistent use before deciding if it’s effective for you.

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Last updated: February 2026