Best Beta Glucan Supplements for Immunity (2026) – Top 10 Reviewed
Beta glucan supplements have become one of the most science-backed options for natural immune support. These polysaccharides, derived from yeast, mushrooms, and algae, work by activating key immune cells like macrophages and natural killer cells to keep your body’s defenses primed and ready.
The most effective beta glucan supplements use the 1,3/1,6 configuration from baker’s yeast or algae sources, which research shows provides superior bioavailability and immune cell activation. Here are our top 10 picks for 2026.
| Product | Key Ingredients | Servings | Form | Best For |
|---|---|---|---|---|
| Zazzee Extra Strength 1,3/1,6 Beta Glucans | 1000mg Beta Glucan | 90 | Capsules | Best Overall |
| Transfer Point Beta 1,3D Glucan 500mg | 500mg Pure Beta Glucan | 60 | Capsules | Best Premium |
| NOW Foods Beta-Glucans with ImmunEnhancer | 250mg Beta Glucan + Larch | 60 | Capsules | Best Value |
| Horbaach Beta Glucan 1,3D 1000mg | 1000mg Beta Glucan | 90 | Capsules | Best Budget |
| Pure Synergy SuperPure Beta 1,3-Glucan | 500mg Algae Beta Glucan | 60 | Capsules | Best Algae-Based |
| Toku Flow Functional Daily Powder | Oat Beta Glucan + Nattokinase | 30 | Powder | Best Multi-Benefit |
| Beta Glucan Supplement 1100mg | 1100mg Beta Glucan | 60 | Capsules | Best High-Potency |
| Transfer Point Beta Glucan 100mg | 100mg Pure Beta Glucan | 60 | Capsules | Best for Beginners |
| Akkermansia GLP-1 Probiotic with Beta-Glucan | Beta Glucan + Akkermansia | 30 | Capsules | Best Gut-Immune Combo |
| Zooawa Mushroom Ergothioneine Complex | Mushroom Beta Glucans | 60 | Capsules | Best Mushroom Blend |
1. Zazzee Extra Strength 1,3/1,6 Beta Glucans – Best Overall
Why it stands out: Zazzee delivers a full 1000mg of 100% concentrated beta glucan per capsule with no fillers, making it one of the most potent options on the market. The formula uses the scientifically-backed 1,3/1,6 configuration for optimal immune cell activation, and the brand has built a strong reputation for transparency and quality.
Each capsule provides a therapeutic dose that research suggests can meaningfully support immune function. The vegan capsules are made without GMOs, artificial ingredients, or common allergens including gluten, soy, and dairy. With 90 capsules per bottle, you get a three-month supply at a competitive price point that beats many lower-dosed competitors on a per-milligram basis. Zazzee’s manufacturing follows strict quality standards with third-party testing for purity and potency, and the company provides detailed certificates of analysis upon request. Users consistently report reduced frequency of colds and faster recovery times when taking this supplement regularly.
Pros:
- Full 1000mg dose per capsule—no need for multiple pills
- 100% concentrated beta glucan content with no fillers
- 90 servings per bottle offers excellent long-term value
- Vegan, non-GMO, and free from major allergens
- Third-party tested with certificates available
Cons:
- Premium price compared to basic options
- May be more than needed for general maintenance
Best for: Anyone seeking a high-potency, well-tested beta glucan supplement for daily immune support without the hassle of multiple capsules.
2. Transfer Point Beta 1,3D Glucan 500mg – Best Premium
Why it stands out: Transfer Point uses the patented Glucan 300® ingredient, which independent research has shown to be significantly more bioavailable and biologically active than competing beta glucan sources. This is the gold standard that many clinical studies reference, backed by over 50 peer-reviewed publications.
Derived from Saccharomyces cerevisiae (baker’s yeast) and GRAS-rated by the FDA, this supplement delivers highly purified beta 1,3D glucan without fillers or additives. The manufacturing process removes inactive components of the yeast cell wall, leaving only the immunologically active beta glucan fraction. The capsules can be opened to mix with applesauce or other foods for those who have difficulty swallowing pills, making it family-friendly. Transfer Point recommends taking on an empty stomach 30 minutes before eating for optimal absorption. The company operates as a small business with hands-on quality control, and their specific beta glucan formulation has been tested head-to-head against competitors with consistently superior results in immune cell activation studies.
Pros:
- Backed by extensive peer-reviewed research and head-to-head comparisons
- Highly purified with no fillers for maximum biological activity
- Can be mixed with food if needed for easy administration
- Small business with dedicated quality control and customer service
- GRAS-rated and non-GMO certified
Cons:
- Higher price point than budget options
- Requires empty stomach for best absorption results
Best for: Those who want the most research-backed beta glucan with proven superior bioavailability and are willing to invest in quality.
3. NOW Foods Beta-Glucans with ImmunEnhancer – Best Value
Why it stands out: NOW combines beta 1,3/1,6 glucan with ImmunEnhancer™, a larch arabinogalactan extract that provides additional immune support through a different mechanism. This dual-action formula delivers more comprehensive immune support for your dollar from one of the most trusted names in supplements.
Each capsule provides 250mg of beta glucans derived from baker’s yeast, completed with the ImmunEnhancer polysaccharide from Western Larch trees. Larch arabinogalactan is a prebiotic fiber that supports beneficial gut bacteria while also directly interacting with immune cells, complementing the beta glucan’s effects. NOW’s GMP-certified manufacturing ensures consistent quality across every batch, and the vegan capsules are free from major allergens including wheat, gluten, soy, milk, egg, fish, and shellfish. The flexible dosing allows you to take 2 capsules up to 3 times daily depending on your immune demands, giving you control over your supplementation level. NOW Foods is a family-owned company with over 55 years in the industry and a reputation for delivering quality supplements at accessible prices. User reviews consistently praise this product for reducing cold frequency and severity.
Pros:
- Combines two proven immune-supporting ingredients
- Excellent price-to-value ratio from a trusted brand
- GMP-certified manufacturing with consistent quality
- Flexible dosing options for personalized use
- Free from all major allergens
Cons:
- Lower beta glucan dose per capsule requires multiple pills for higher doses
- ImmunEnhancer adds bulk, reducing room for beta glucan
Best for: Budget-conscious buyers who want quality immune support with added benefits from a reputable, established manufacturer.
4. Horbaach Beta Glucan 1,3D 1000mg – Best Budget
Why it stands out: Horbaach delivers a full 1000mg of beta 1,3/1,6 glucan per serving at one of the lowest prices in the category. Quick-release capsules ensure efficient absorption without sacrificing quality.
Sourced from baker’s yeast cell walls, this extra-strength formula contains 70% beta glucans 1,3/1,6. Horbaach has been in the supplement industry for over 40 years, focusing on lab-tested products at accessible prices. The formula is naturally free from gluten, wheat, milk, lactose, soy, and artificial ingredients. With 90 capsules per bottle, you get a solid three-month supply at a fraction of premium brands’ cost.
Pros:
- Most affordable high-dose option
- 70% beta glucan concentration
- Non-GMO and allergen-free
- Long-established manufacturer
Cons:
- Less research on this specific formulation compared to premium brands
Best for: Those seeking effective beta glucan supplementation without breaking the bank.
5. Pure Synergy SuperPure Beta 1,3-Glucan – Best Algae-Based
Why it stands out: This is the first algae-based, yeast-free beta glucan supplement on the market. Derived from Euglena gracilis freshwater algae using water extraction, it’s ideal for those with yeast sensitivities or who prefer plant-based sources.
Each capsule delivers an unprecedented 500mg of pure beta 1,3-glucan without the branched 1,6 linkages found in yeast. The linear structure of algae-derived beta glucan may interact more efficiently with immune cells according to some research. Pure Synergy is a Certified B Corp based in Moab, Utah, committed to organic and sustainable practices. The extraction process uses only purified water, leaving zero chemical residues. Users report noticeable energy improvements and reduced illness frequency.
Pros:
- Yeast-free and allergen-friendly
- Clean water extraction method
- Certified B Corp with sustainable practices
- Linear structure for optimal immune interaction
Cons:
- Premium pricing
- Limited research compared to yeast-derived options
Best for: Anyone with yeast allergies or those seeking the purest algae-based option.
6. Toku Flow Functional Daily Powder – Best Multi-Benefit
Why it stands out: Toku Flow combines oat beta glucan with nattokinase and vitamin K2, creating a comprehensive formula that supports both immune health and cardiovascular function in one convenient powder.
This unique powder formula provides 10,800 FU of soy-free nattokinase alongside oat-derived beta glucan, addressing both immunity and circulation in a single daily serving. Oat beta glucans are particularly well-studied for their cholesterol-lowering effects in addition to immune support. The powder format allows for easy mixing into smoothies, water, or other beverages. Vitamin K2 MK7 adds bone and cardiovascular benefits, making this an excellent choice for those wanting multiple health benefits from one supplement.
Pros:
- Combines immune and cardiovascular support
- Convenient powder format
- Includes nattokinase and K2
- Oat beta glucans with cholesterol benefits
Cons:
- Powder may not suit everyone’s preference
- Lower beta glucan concentration than focused supplements
Best for: Those seeking comprehensive daily support for immunity, heart health, and circulation.
7. Beta Glucan Supplement 1100mg – Best High-Potency
Why it stands out: With 1100mg of beta 1,3D and 1,6 glucans per serving, this is among the highest-dosed options available. The formula specifically targets immunity, skin health, and gut support.
This extra-strength formula delivers a powerful dose of both 1,3D and 1,6 beta glucan configurations, covering multiple pathways of immune activation. The combination supports not just immune cells but also skin barrier function and digestive health. Made in the USA in a GMP-certified facility, the supplement undergoes third-party testing for quality assurance. Users particularly note improvements in skin appearance and reduced frequency of upper respiratory issues.
Pros:
- Among the highest doses available
- Supports immunity, skin, and gut
- Made in GMP-certified USA facility
- Third-party tested
Cons:
- May be more than needed for general maintenance
- Larger serving size required
Best for: Those seeking maximum-strength immune support and additional skin/gut benefits.
8. Transfer Point Beta Glucan 100mg – Best for Beginners
Why it stands out: This lower-dose version of Transfer Point’s premium formula is perfect for those new to beta glucan or smaller individuals who don’t need a full 500mg dose. Same high purity, gentler introduction.
Using the same highly purified Glucan 300® as their premium product, the 100mg capsules allow for personalized dosing. Transfer Point recommends dosing based on body weight, making this ideal for individuals under 100 lbs or those who want to start low and increase gradually. The smaller dose is also popular for pets, as beta glucan is safe for dogs and horses. The microcrystalline cellulose filler is minimal and vegetarian-friendly.
Pros:
- Same premium quality in starter dose
- Allows precise, weight-based dosing
- Suitable for pets as well
- More affordable entry point to Transfer Point
Cons:
- May need multiple capsules for larger individuals
- Higher cost per mg than bulk options
Best for: First-time beta glucan users, smaller individuals, or pet owners.
9. Akkermansia GLP-1 Probiotic with Beta-Glucan – Best Gut-Immune Combo
Why it stands out: This innovative formula combines soluble beta-glucan prebiotic fiber with Akkermansia probiotics and berberine, targeting the gut-immune axis that research increasingly shows is central to overall health.
The delayed-release capsules ensure the Akkermansia bacteria survive stomach acid to colonize the gut, where they work synergistically with beta-glucan fiber. Akkermansia muciniphila is associated with healthy metabolism and immune function, while berberine provides additional metabolic support. This is particularly relevant given the connection between gut health and immune response—approximately 70% of immune cells reside in the gut. The combination approach addresses immunity from multiple angles.
Pros:
- Addresses gut-immune connection
- Includes trending Akkermansia probiotic
- Delayed-release technology
- Multiple synergistic ingredients
Cons:
- Complex formula may not suit those wanting pure beta glucan
- Premium pricing for combination product
Best for: Those interested in the gut-immune connection and comprehensive metabolic support.
10. Zooawa Mushroom Ergothioneine Complex – Best Mushroom Blend
Why it stands out: This unique formula combines fermentation-based L-ergothioneine with mushroom-derived beta glucans, offering a different approach to immune support through fungal compounds that have been used in traditional medicine for centuries.
Mushroom beta glucans have a branched 1,3/1,6 structure that activates immune cells through slightly different pathways than yeast-derived versions. The addition of ergothioneine, a powerful antioxidant found in mushrooms, provides cellular protection alongside immune activation. This supplement draws on both modern fermentation technology and traditional knowledge about medicinal mushrooms. The 10mg of ergothioneine per serving is a meaningful dose of this increasingly popular longevity compound.
Pros:
- Combines mushroom beta glucans with ergothioneine
- Fermentation-based for purity
- Traditional and modern approach combined
- Antioxidant and immune benefits
Cons:
- Lower beta glucan content than focused supplements
- Less research than yeast-based options
Best for: Those interested in mushroom-based immunity and the emerging science around ergothioneine.
What is Beta Glucan and Who Should Take It?
Beta glucans are naturally occurring polysaccharides found in the cell walls of bacteria, fungi, yeasts, and certain grains like oats and barley. The 1,3/1,6 configuration from yeast and fungi has been most extensively studied for immune support, while oat beta glucans are better known for cholesterol management. These compounds have been researched for over 60 years, with the first discoveries dating back to the 1940s when scientists noticed that certain yeast extracts could activate immune cells.
The molecular structure of beta glucans matters significantly for their effects. Yeast-derived beta glucans typically have a branched structure with both 1,3 and 1,6 linkages, which allows them to interact with multiple immune cell receptors. Algae-derived beta glucans tend to have a more linear 1,3 structure that may interact differently with immune cells. Oat and barley beta glucans have a different configuration altogether (1,3/1,4 linkages) that makes them more effective for cholesterol binding in the gut rather than direct immune activation.
These compounds work by binding to specific receptors on immune cells—particularly Dectin-1 on macrophages, dendritic cells, and natural killer cells—essentially “priming” your immune system to respond more effectively to threats. When beta glucan binds to these receptors, it triggers a cascade of immune responses including enhanced phagocytosis (the process by which immune cells engulf pathogens), increased production of cytokines (immune signaling molecules), and improved coordination between different parts of the immune system. Unlike immune stimulants that can cause overactivation and potentially worsen autoimmune conditions, beta glucans are considered immunomodulators that help balance immune response.
People who may benefit most from beta glucan supplementation include those frequently exposed to pathogens (healthcare workers, teachers, parents of young children), individuals recovering from illness or surgery, anyone seeking year-round immune support, people with high stress levels that may suppress immunity, older adults experiencing age-related immune decline, and athletes who may experience temporary immune suppression from intense training.
How to Choose the Right Beta Glucan Supplement
Key Ingredients to Look For
The most effective immune-supporting beta glucans use the 1,3/1,6 linkage configuration, primarily derived from baker’s yeast (Saccharomyces cerevisiae) or algae (Euglena gracilis). Research suggests doses between 100-500mg daily are effective for general immune maintenance, while higher doses up to 1000mg may benefit those with increased immune demands. Look for products that specify the percentage of active beta glucans—ideally 70-100% glucan content, as lower concentrations may contain significant amounts of inactive yeast cell wall material.
The purity of the beta glucan extract matters enormously for biological activity. Independent research has shown that highly purified beta glucans can be many times more effective than crude extracts at the same dose. When comparing products, look for brands that reference specific testing or patented ingredients (like Glucan 300® or Wellmune®) that have been validated in clinical studies. Third-party testing certificates and GMP certification provide additional assurance of quality.
Yeast-derived options have the most research backing their immune benefits, with dozens of peer-reviewed studies demonstrating effects on immune cell activity, respiratory infection rates, and recovery times. Algae-based alternatives work well for those with yeast sensitivities and offer the advantage of being free from potential yeast allergens and contaminants. Some products combine beta glucan with complementary ingredients like vitamin C, vitamin D, zinc, or other immune supporters to provide a more comprehensive approach.
Forms Compared
Capsules are the most common and convenient format, with vegetarian and vegan options widely available. Standard gelatin capsules work fine for most people, but vegetable cellulose capsules are preferred for those avoiding animal products. Quick-release capsules may offer faster absorption, while some premium products use specialized delivery systems.
Powders offer flexibility for those who prefer mixing into beverages and allow for easier dose adjustment. This format is particularly useful for oat-derived beta glucans that require higher doses (3+ grams daily) for cholesterol benefits. Powders can be mixed into smoothies, water, juice, or even food. Some people find the powder format more economical since it eliminates the cost of capsule materials.
Combination products that include beta glucan with probiotics, mushroom extracts, or other immune supporters can provide a more comprehensive approach in a single supplement. However, these products may contain lower doses of beta glucan to make room for other ingredients, so check the label carefully to ensure you’re getting a therapeutic dose.
What to Avoid
Steer clear of products that don’t specify the type of beta glucan or its source—generic “beta glucan” claims without details suggest a manufacturer that hasn’t invested in quality sourcing. Avoid supplements with excessive fillers, binders, and flow agents that dilute the active ingredient. Magnesium stearate, silicon dioxide, and cellulose in small amounts are generally acceptable, but the active ingredient should be the primary component.
Be wary of extremely low-priced options that may not contain meaningful doses or may use crude, unpurified extracts with lower biological activity. While you don’t necessarily need the most expensive option, suspiciously cheap beta glucan supplements should raise questions about quality and efficacy. Products claiming to treat or cure diseases should be avoided as these claims are not supported by regulations and may indicate an unreliable manufacturer cutting corners in other areas.
Side Effects and Precautions
Beta glucan supplements are generally well-tolerated with few reported side effects across decades of research and widespread use. Some people may experience mild digestive symptoms like bloating, gas, or loose stools when first starting supplementation, particularly at higher doses. These effects typically resolve within a few days as the body adjusts. Starting with a lower dose and gradually increasing can help minimize initial digestive discomfort. Taking beta glucan with food may also reduce stomach upset, though absorption may be slightly reduced.
Those with mushroom or yeast allergies should exercise caution and choose algae-based options or consult their healthcare provider before use. While highly purified yeast-derived beta glucans are generally safe for those with mild yeast sensitivities, individuals with true yeast allergies should opt for algae sources to be safe. People taking immunosuppressant medications (such as those used after organ transplants or for autoimmune conditions) should consult their doctor before using beta glucan, as the immune-activating effects could potentially interfere with treatment goals.
Individuals with autoimmune conditions like lupus, rheumatoid arthritis, or multiple sclerosis should seek medical guidance before starting beta glucan supplementation. While beta glucans are immunomodulators rather than simple immune stimulants, the effect on autoimmune conditions is not fully understood and caution is warranted. Pregnant and breastfeeding women should consult healthcare providers before starting any new supplement, including beta glucan, as safety data in these populations is limited. Beta glucan is generally considered safe for children, but parents should choose age-appropriate formulations and consult with pediatricians regarding appropriate dosing.
FAQs
How much beta glucan should I take daily?
For general immune support, research suggests 100-500mg of yeast-derived beta 1,3/1,6 glucan daily is effective. Some protocols recommend dosing based on body weight—approximately 100mg per 50 lbs of body weight. Higher doses up to 1000mg may benefit those with increased immune demands or during cold and flu season.
Should I take beta glucan on an empty stomach?
Most research and manufacturers recommend taking beta glucan on an empty stomach, typically 30 minutes before meals. This allows for optimal absorption without interference from food. However, if you experience stomach discomfort, taking it with a small amount of food is acceptable and still provides benefits.
How long does it take to see results from beta glucan?
Many users report noticing benefits within 2-4 weeks of consistent daily use, particularly in terms of reduced frequency of minor illnesses. Research on upper respiratory infections typically shows benefits after 4 weeks of supplementation. For optimal results, consistent daily use over several months is recommended rather than occasional supplementation.
Can I take beta glucan with other supplements?
Yes, beta glucan generally combines well with other immune-supporting supplements like vitamin C, vitamin D, and zinc. Some products are specifically formulated with these combinations. However, if you’re taking medications, particularly immunosuppressants, consult your healthcare provider before combining supplements.
Is yeast-derived or algae-derived beta glucan better?
Both sources are effective, but they have different characteristics. Yeast-derived beta 1,3/1,6 glucan has the most extensive research backing its immune benefits. Algae-derived beta 1,3 glucan offers a yeast-free alternative with a linear structure that some research suggests may have unique immune interactions. Choose based on allergies, preferences, and individual response.
Can children take beta glucan supplements?
Some beta glucan products are formulated specifically for children and have been studied for reducing respiratory infections in pediatric populations. However, dosing differs for children, and parents should choose age-appropriate formulations and consult their pediatrician before starting any supplement regimen for children.
Final Verdict
For most people seeking reliable, research-backed immune support, Zazzee Extra Strength 1,3/1,6 Beta Glucans offers the best combination of potency, purity, and value with its full 1000mg dose per capsule.
If you want the most scientifically validated option regardless of price, Transfer Point Beta 1,3D Glucan has the most peer-reviewed research behind its specific formulation. Budget-conscious buyers will find excellent value in NOW Foods Beta-Glucans with ImmunEnhancer, which adds larch arabinogalactan for enhanced immune support.
Those with yeast allergies should opt for Pure Synergy SuperPure Beta 1,3-Glucan from algae. And if you’re looking for comprehensive gut-immune support, the Akkermansia GLP-1 Probiotic with Beta-Glucan addresses the increasingly recognized connection between digestive health and immunity.
