Best Betaine Anhydrous Supplements (2026) – Top 10 Reviewed
Betaine anhydrous, also known as trimethylglycine (TMG), is a powerful supplement that enhances muscle strength, power output, and body composition. If you’re looking to maximize training performance and support creatine synthesis, you’ll find our top-tested betaine anhydrous supplements below.
Our Top Picks at a Glance
- Best Overall: BulkSupplements TMG Powder – bulk value and purity
- Best Capsules: NatureBell TMG 1500mg – maximum potency capsules
- Best Value: Nutricost Betaine Powder – affordable quality
Quick Comparison
| Product | Key Features | Form | Servings | Best For |
|---|---|---|---|---|
| BulkSupplements TMG 1kg | 1500mg, Unflavored | Powder | 666 | Overall use |
| NatureBell 1500mg | Max Strength, 240 Capsules | Capsules | 120 | Convenience |
| Nutricost Powder 500g | Pure TMG, Non-GMO | Powder | 333 | Budget buyers |
| BulkSupplements Capsules | 1500mg, 240 Count | Capsules | 120 | Precise dosing |
| 10X Health TMG | Energy Support | Capsules | 60 | Vitality boost |
| EVL RPM Energy | With Pre-Workout | Powder | 30 | Complete formula |
| TNVitamins TMG 1000mg | 120 Tablets, USA Made | Tablets | 60 | Heart health |
1. BulkSupplements TMG Powder 1kg – Best Overall
- ✔️ Maximize Energy Support Daily: Loaded with natural energy boosting properties, TMG powder is fast-acting and provides maximum energy support for those days when you need a little extra boost in order to push harder and longer.* Get the energy support you need to maximize your goals!
- ✔️ Natural Way for Mood Support: Get a grip on your moods with this all pure & clean TMG supplement.* Let a daily dose of our Betaine Anhydrous powder provide your body with the natural elements it needs to keep you feeling balanced and healthy.*
- ✔️ No Unwanted Extras!: Gluten free and perfect for all diets! This TMG supplement, or Betaine supplement, contains no dairy, soy, sugar or artificial flavor of any kind for a healthy and balanced diet. Plus, our Betaine Anhydrous powder, or TMG powder, is perfect for any leading an active lifestyle!*
- ✔️ Mixes Easilty: Easy to dissolve and mix into shakes and smoothies! Just add 1/2 tsp, or 1500mg, of our clean source of Betaine Anhydrous powder, or TMG powder, to give you an extra edge in your daily routine or any intense activity!
- ⭐ High Quality: Made from the quality ingredients, our Betaine Anhydrous powder, TMG supplements, is carefully produced in a cGMP certified facility for the highest degree of purity and safety. All products are thoroughly tested to ensure their quality and potency.
BulkSupplements delivers 666 servings of pure betaine anhydrous powder for maximum value and performance support.
This 1-kilogram container provides 1500mg of trimethylglycine per serving with no fillers or additives. The unflavored powder mixes easily into pre-workout drinks, protein shakes, or water. Third-party tested and manufactured to cGMP standards for consistent quality. Perfect for athletes seeking to enhance strength, power output, and body composition at the best per-serving value.
What We Like
- Massive 666 servings per container
- Pure betaine anhydrous with no fillers
- Third-party tested for quality
- cGMP certified manufacturing
- Best value per serving available
What Could Be Better
- Requires manual measuring
- Large container may be excessive for new users
Bottom Line: BulkSupplements TMG Powder offers exceptional purity and value for serious athletes who use betaine regularly to enhance training performance.
2. NatureBell TMG 1500mg Capsules – Best Capsule Option
- Maximum potency TMG capsules, 1,500mg trimethylglycine per serving, stable betaine anhydrous form, essential for natural homocysteine balance, heart, and liver health.
- Each bottle contains 240 capsules, providing a high bioavailable form and stable supply of TMG for men and women.
- TMG's potent methyl-donating properties support natural longevity and youthful aging, it plays a crucial role in various cellular processes that keep the body running smoothly.
- Whether you’re an athlete or office worker, TMG offers natural energy by supporting creatine synthesis, which promotes lasting energy during any activity.
- Authentic non-GMO ingredients that are free of wheat, soy, dairy, gluten, eggs, fish, shellfish, peanuts, and tree nuts. All products are also 3rd party lab tested for safety and potency.
NatureBell provides maximum potency 1500mg TMG capsules for convenient, pre-measured supplementation.
This 240-capsule container delivers 120 servings of betaine anhydrous in its stable, highly bioavailable form. The formula supports healthy homocysteine balance, heart health, and liver wellness. Non-GMO and free from common allergens including gluten, soy, dairy, and nuts. Third-party lab tested for safety and potency.
What We Like
- Maximum 1500mg potency per serving
- Convenient pre-measured capsules
- 240-capsule long-term supply
- Non-GMO and allergen-free
- Third-party tested for purity
What Could Be Better
- Higher cost per gram than powder
- Two capsules per serving required
Bottom Line: NatureBell TMG Capsules offer maximum potency in convenient form for athletes who prefer pre-measured dosing without powder mess.
3. Nutricost Betaine Anhydrous Powder 500g – Best Value
- 500 Grams of Betaine Anhydrous (TMG) Per Bottle
- Tested By Independent (3rd party) ISO-Accredited Laboratories
- Serving Size: 1 Scoop (1.5g) (Included)
- Vegetarian, Non-GMO, Gluten Free
- Made in a GMP Compliant, FDA Registered Facility
Nutricost delivers pure betaine anhydrous powder at an exceptional price point for budget-conscious athletes.
This 500-gram container provides 333 servings of TMG with no GMOs or artificial ingredients. The gluten-free, unflavored powder mixes easily with other supplements or beverages. Manufactured in a GMP-compliant facility for quality assurance. Perfect for athletes who want effective betaine supplementation without premium pricing.
What We Like
- Excellent price-to-quality ratio
- 333 servings for long-term use
- Pure TMG with no additives
- Non-GMO and gluten-free
- GMP-certified manufacturing
What Could Be Better
- Smaller container than 1kg options
- May need frequent reordering
Bottom Line: Nutricost Betaine Powder provides reliable quality at budget-friendly pricing, ideal for cost-conscious athletes seeking performance benefits.
4. BulkSupplements TMG Capsules 1500mg – Best Precise Dosing
- Maximize your Potential: Take your active lifestyle to the next level with our Trimethylglycine capsules, also known as Betaine Anhydrous. Each serving is tailored to support your strength and fitness goals, perfect for anyone aiming to enhance their performance and achieve more.
- Versatility for all Lifestyles: Whether you're an athlete, a sprinter, or someone simply looking to stay active, our TMG Trimethylglycine supplement, in TMG capsules, fits seamlessly into your regimen, adaptable to a wide range of dietary needs and preferences.
- Nutritional Component – Each serving provides TMG (trimethylglycine) in convenient capsule form, a naturally occurring compound commonly included in nutritional formulations. This ingredient delivers a consistent source of TMG without added fillers, flavors, or colors, making it suitable for customers seeking a straightforward and easy-to-use supplement for their daily routine.
- Produced in a cGMP-Compliant Facility: Manufactured in a facility that follows current Good Manufacturing Practices (cGMP), ensuring a consistent and reliable product. This reflects our commitment to quality and care in every step of the process.
- Made with Quality and Integrity: All our supplements are produced with a focus on clarity, consistency, and high standards. Every batch is tested to help ensure quality and peace of mind for wellness-focused consumers.
BulkSupplements offers 240 capsules delivering 1500mg TMG per serving for convenient, precise supplementation.
This capsule version provides the same quality as BulkSupplements powder in pre-measured form. Each serving contains 1500mg of betaine anhydrous to support strength and fitness goals. Gluten-free and third-party tested for purity and potency. Perfect for athletes who want BulkSupplements quality without measuring powder.
What We Like
- Same BulkSupplements quality in capsules
- 1500mg per convenient serving
- 240 capsules for long-term use
- Third-party tested for purity
- No measuring or mixing required
What Could Be Better
- More expensive than powder form
- Two capsules per serving
Bottom Line: BulkSupplements TMG Capsules combine trusted quality with convenient dosing for athletes who prefer capsules over powder.
5. 10X Health TMG Supplements – Best Energy Support
- Better Heart Health: Support heart health with 10X TMG, a trimethylglycine supplement rich in glycine betaine to support good homocysteine levels and methylation. Trusted homocysteine supplements for heart support and methylated vitamins synergy.
- Supports Optimal Homocysteine Levels: Backed by science, our high-potency TMG supplement helps maintain optimal homocysteine levels. Use with homocysteine supplements for complete support and overall wellness.
- Clean Amino Acids for Wellness: Formulated with 1000mg betaine TMG (per 2-capsule serving) and glycine betaine, these TMG supplements 1000mg support liver function, methylation cycles, and cellular balance, crafted for long-term wellness and vitality.
- Boosts Energy and Vitality: Supercharge your vitality with 10X TMG, crafted to support energy, mitochondrial health, and performance. Powered by Betaine Anhydrous, it’s your go-to betaine TMG for strength, stamina, and complete cellular function.
- Quality and Safety Assured: The 10X TMG Supplements from 10X Health System are made with premium ingredients, put through careful testing to ensure potency and purity, and are perfect for people looking to take control of their health and wellness.
10X Health provides TMG capsules specifically formulated to support energy, vitality, and cellular function.
This formula uses betaine anhydrous to supercharge vitality and support mitochondrial health alongside energy production. The capsules promote liver support, heart wellness, and healthy homocysteine levels. Non-GMO and gluten-free for clean supplementation. Designed for athletes seeking both performance and overall wellness benefits.
What We Like
- Supports energy and vitality
- Promotes mitochondrial health
- Benefits liver and heart wellness
- Non-GMO and gluten-free
- Clean ingredient profile
What Could Be Better
- Smaller container than bulk options
- Higher price per serving
Bottom Line: 10X Health TMG is ideal for athletes who want betaine benefits for both training performance and overall energy support.
6. EVL RPM Energy Pre Workout – Best Complete Formula
- Maximum Energy - Try our preworkout energy powder drink mix with unique invigorating ingredients like Theacrine and Dynamine plus extended release caffeine and Vitamin B12 for long lasting energy
- Boost Endurance - Get the most out of your workouts with enhanced stamina thanks to endurance maximizing ingredients like Betaine 1000mg L-tyrosine 500mg Taurine 1000mg
- Laser Focus - Forget about those basic pre workout supplements for men and say hello to our RPM energy and focus powder with Theobromine and Huperzine A to keep you dialed in for serious workouts
- Uncompromising Quality - Choose EVL and our new pre workout for men with breakthrough ingredients like Dynamine and Caffeine microspheres for intense pumps amplified power and maximum performance
- Why Evlution Nutrition - EVL is a leading name in advanced bodybuilding supplements for men because we take our training seriously and only use the finest lab tested performance maximizing formulas
EVL combines betaine anhydrous with other performance ingredients for comprehensive pre-workout support.
This complete formula includes betaine alongside caffeine and other proven ingredients for energy and performance. The combination supports power output, endurance, and focus during training. Multiple flavor options available for better taste. Perfect for athletes who want betaine as part of an all-in-one pre-workout.
What We Like
- Combines betaine with pre-workout ingredients
- Supports power and endurance
- Includes caffeine for energy
- Complete pre-workout solution
- Great-tasting flavors available
What Could Be Better
- Lower betaine dose than pure supplements
- Contains caffeine (not for everyone)
Bottom Line: EVL RPM Energy is perfect for athletes who want betaine combined with complete pre-workout ingredients for maximum training intensity.
7. TNVitamins TMG 1000mg – Best for Heart Health
- ✔️ TMG (Trimethylglycine) is Also Known As Betaine Anhydrous
- ✔️ 1,000 mg of TMG (Trimethylglycine) per 2 Tablet Serving. 120 Tablets Per Bottle. 2 Month Supply!
- ✔️ Betaine Anhydrous is a Better Form of Betaine HCL (Betaine Hydrochloride). This is because Betaine Anhydrous Has Better Solubility Than Betain HCL. In Addition, Betaine Hydrochoride May Lower the PH Level of the Stomach, Which May Affect How Nutrients are Absorbed.*
- ✔️ Trimetheylglycine (TMG), or Betaine Anhydrous, Has Been Used For Its Many Different Health Benefits. These include Cardiovascular Health by Supporting Healthy Homocysteine Levels. In addition, many People take TMG Supplements in order to Support Healthy Liver Function. Others take Betaine Anhydrous for Athletic and Exercise Performance Support, Including Endurance and Recovery. Finally, Other Health Benefits include Brain and Mood Support, as well as Hydration and Cellular Function.*
- ✔️ TNVitamins TMG Betaine Anhydrous is Non-GMO, and Made in the USA! It is also Free Of: Gluten, Milk, Eggs, Crustaceans, Fish, Peanuts, Tree Nuts, and Soy!
TNVitamins provides TMG tablets focused on cardiovascular and liver health support.
This USA-made formula delivers 1000mg of betaine anhydrous per serving to support healthy homocysteine levels and cardiovascular function. The tablets are free from common allergens including gluten, milk, eggs, fish, and nuts. Designed for athletes concerned with both performance and long-term health.
What We Like
- Supports cardiovascular health
- 1000mg per convenient tablet serving
- Made in USA for quality
- Allergen-free formulation
- 120 tablets per container
What Could Be Better
- Lower dose than 1500mg options
- May need higher serving for performance
Bottom Line: TNVitamins TMG is ideal for athletes who want betaine benefits for both training performance and cardiovascular wellness.
How to Choose the Best Betaine Anhydrous Supplement
When selecting a betaine anhydrous supplement, prioritize pure TMG (trimethylglycine) over betaine HCl. Betaine anhydrous has better solubility and doesn’t lower stomach pH like betaine hydrochloride, making it superior for athletic performance. Look for products clearly labeled as “betaine anhydrous” or “trimethylglycine” rather than generic “betaine.”
Consider the clinically effective dose for your goals. Research suggests 2.5-4g daily for strength and power enhancement, typically split into two doses of 1.25-2g. Choose products providing 1000-1500mg per serving to easily reach effective levels. Lower doses may not deliver the performance benefits supported by research.
Evaluate the form factor based on your preferences and lifestyle. Powder offers best value and dosing flexibility but requires measuring and mixing. Capsules and tablets provide convenience and precise dosing but cost more per gram. Consider how you’ll use betaine most often – mixed in pre-workout or taken separately as capsules.
Look for third-party testing and quality certifications. Reputable brands test for purity, potency, and contaminants. Check for cGMP certification indicating good manufacturing practices. Avoid products with excessive fillers, flow agents, or artificial additives that don’t contribute to performance.
Finally, calculate the true cost per effective dose. A 1500mg capsule at slightly higher price may offer better value than 1000mg requiring additional servings. Factor in your usage frequency – daily users benefit from bulk powder, while occasional users may prefer smaller capsule containers. Consider your budget and training consistency to find optimal value.
Benefits of Betaine Anhydrous Supplements
Betaine anhydrous enhances muscle strength and power output through multiple mechanisms. Research shows that supplementing with 2.5g daily increases mean power, average power, and maximum peak power across training sessions. As a methyl donor, betaine supports creatine synthesis in the body, potentially amplifying the strength benefits you get from creatine supplementation while also working independently to boost force production.
Studies demonstrate that betaine improves body composition by supporting fat metabolism while preserving muscle mass. The compound may enhance fat oxidation during training while supporting protein synthesis for muscle growth. Athletes taking betaine anhydrous alongside resistance training typically see better improvements in lean mass and reductions in body fat compared to training alone.
Betaine acts as an osmolyte, helping regulate water and salt balance within cells. This cellular hydration effect may contribute to improved muscle endurance and reduced fatigue during high-intensity training. By maintaining optimal cellular environment, betaine helps muscles function more efficiently during both training and recovery periods.
Beyond performance, betaine supports cardiovascular health by helping convert homocysteine into methionine. Elevated homocysteine levels are associated with cardiovascular risk, and betaine supplementation (2-4g daily) helps maintain healthy homocysteine levels. This dual benefit makes betaine valuable for athletes focused on both immediate performance and long-term health.
Frequently Asked Questions
What is betaine anhydrous and how does it work?
Betaine anhydrous, also called trimethylglycine (TMG), is a compound derived from choline and found naturally in beets and spinach. It works as a methyl donor in the body, supporting creatine synthesis and various metabolic processes. In muscle tissue, betaine helps regulate cellular hydration and may enhance protein synthesis, leading to improved strength, power output, and body composition.
When should I take betaine for best results?
Take betaine split into two doses daily for optimal results. Research typically uses 1.25g twice daily (morning and pre-workout) for a total of 2.5g per day. Some athletes take a single 2.5-4g dose pre-workout for convenience. Betaine doesn’t require specific timing like some supplements, so consistency matters more than precise timing around training.
How much betaine should I take per dose?
Effective doses range from 2.5-4g total per day based on research. Most studies showing strength and power benefits use 2.5g daily, often split into 1.25g twice daily. Some athletes use up to 4-5g daily for maximum effects. Start with 2.5g daily to assess tolerance, then increase to 4g if desired for potentially greater benefits.
Can I stack betaine with other supplements?
Yes, betaine stacks excellently with other performance supplements. It works synergistically with creatine (betaine supports creatine synthesis), protein for muscle building, pre-workout ingredients for enhanced performance, and BCAAs for recovery support. Many pre-workout formulas include betaine alongside these ingredients for comprehensive performance enhancement.
What’s the difference between betaine anhydrous and betaine HCl?
Betaine anhydrous (trimethylglycine) is the pure form used in athletic performance research and has better solubility. Betaine HCl (betaine hydrochloride) is primarily used as a digestive aid to increase stomach acid and may lower stomach pH. For sports performance, muscle strength, and body composition goals, betaine anhydrous is the superior choice backed by research.
Are there any side effects of betaine anhydrous?
Betaine anhydrous is generally well-tolerated at recommended doses (2.5-4g daily). Some users report mild digestive discomfort when first starting supplementation. Start with lower doses and increase gradually to minimize any stomach issues. Very high doses may cause fishy body odor in some individuals due to increased choline metabolism. Stick to research-supported doses to minimize side effects.
Will betaine help with muscle growth?
Yes, betaine supports muscle growth through multiple pathways: it enhances protein synthesis, supports creatine production for strength gains, improves cellular hydration for better muscle function, and may boost fat metabolism while preserving muscle during training. When combined with proper resistance training and nutrition, betaine can enhance muscle hypertrophy and improve overall body composition over time.
Is betaine safe for daily long-term use?
Yes, betaine anhydrous is safe for daily long-term use at recommended doses (2.5-4g). Research studies examining chronic supplementation show no adverse effects from continuous daily use. As a naturally occurring compound in foods and the body, betaine has an excellent safety profile. Most athletes use it daily as part of their regular supplement regimen for sustained performance benefits.
