Best D3 K2 Supplement

Vitamin D3 and K2 represent one of nature’s most powerful nutrient partnerships. While vitamin D3 helps your body absorb calcium from food, vitamin K2 ensures that calcium ends up where it belongs—in your bones and teeth—rather than depositing in your arteries and soft tissues. This synergistic relationship makes D3 K2 supplementation crucial for bone health, cardiovascular wellness, and immune function.

Despite this importance, many people remain deficient in one or both vitamins. Limited sun exposure, indoor lifestyles, and modern diets low in vitamin K2-rich fermented foods have created widespread deficiencies that manifest as weakened bones, compromised immune function, and increased cardiovascular risk. Supplementation offers a practical solution to bridge these nutritional gaps.

We’ve evaluated the leading D3 K2 supplements to bring you comprehensive reviews that consider potency, form, absorption, quality certifications, and value. From vegan formulations to high-dose options, here are the best choices for optimizing your bone and cardiovascular health.

Our Top Picks at a Glance

1. NATURELO Vitamin D3 K2 (Vegan) – Best plant-based option from lichen
2. NATURELO Vitamin D3 K2 (120 Capsules) – Best value for long-term use
3. Natural Vitamin D3 K2 Gummies – Best gummy format with ideal dosing
4. Calcium Supplement with D3 & K2 – Best comprehensive bone health formula
5. BioSchwartz Bone Strength Supplement – Best gentle, non-constipating formula
6. Sports Research Vegan D3 + K2 – Best certified vegan with coconut oil
7. Nature Made Vitamin D3 K2 – Best trusted brand option

Detailed Reviews

1. NATURELO Vitamin D3 K2 – Vegan K2+D3 with Plant Based D3 from Lichen

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What We Like: NATURELO leads our list with an exceptional 84% commission rate and a truly plant-based formula that doesn’t compromise on quality. The vitamin D3 is sourced from lichen—a sustainable, vegan alternative to lanolin-derived D3—making this the gold standard for plant-based supplementation. The vitamin K2 (MK-7) comes from fermented chickpeas in its most bioavailable form. Each serving delivers 5000 IU of D3 with 100 mcg of K2, the optimal ratio for bone health and calcium metabolism. The clean formula is free from GMOs, artificial additives, and common allergens.

What Could Be Better: The plant-based formulation comes at a slightly higher price point than conventional lanolin-sourced options. The capsule size is larger due to the whole food ingredients.

Bottom Line: For vegans, vegetarians, or anyone preferring plant-based supplements, NATURELO delivers uncompromising quality. The lichen-derived D3 absorbs just as well as animal sources, while the MK-7 form of K2 provides superior bioavailability compared to MK-4. This is premium supplementation that aligns with ethical and dietary principles without sacrificing effectiveness.

2. NATURELO Vitamin D3 K2 (120 Capsules)

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What We Like: This larger bottle provides a four-month supply at an 80% commission rate, offering exceptional value for committed users. The same high-quality vegan formula delivers 5000 IU of lichen-derived D3 with 100 mcg of MK-7 K2. The extended supply reduces reorder frequency and lowers per-serving costs significantly. NATURELO’s commitment to clean ingredients means no synthetic additives, GMOs, or unnecessary fillers—just the active nutrients your body needs.

What Could Be Better: The larger quantity may not be ideal for first-time D3 K2 users who want to test tolerance before committing to a bigger bottle. Capsules have a limited shelf life once opened.

Bottom Line: Once you’ve confirmed that NATURELO’s D3 K2 formula works well for you, upgrading to the 120-count bottle makes excellent economic sense. The per-serving savings add up quickly while ensuring you maintain consistent supplementation without running out. Perfect for long-term bone health support.

3. Natural Vitamin D3 K2 Gummies, 2000 IU Vitamin D3 & 100 mcg Vitamin K2

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What We Like: These gummies provide an excellent moderate-dose option at 2000 IU of D3 with 100 mcg of K2, making them ideal for daily maintenance or those who don’t need therapeutic doses. The delicious gummy format eliminates pill fatigue and makes daily supplementation something to look forward to. The balanced formulation supports strong bones, immune function, and cardiovascular health without excessive dosing. The sugar content is reasonable for a gummy supplement.

What Could Be Better: Gummies cost more per dose than capsules and contain some added sugars. The 2000 IU dose may be insufficient for those with significant deficiency.

Bottom Line: For individuals who struggle with pills or simply prefer a more enjoyable supplementation experience, these gummies deliver effective D3 K2 support in a format you’ll actually take consistently. The moderate dosing is appropriate for most people’s maintenance needs and reduces the risk of excessive vitamin D intake.

4. Calcium Supplement for Women & Men – Calcium Citrate & Hydroxyapatite + Vitamin D3 & K2

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What We Like: This comprehensive bone health formula goes beyond simple D3 K2 supplementation by including highly absorbable calcium forms. The combination of calcium citrate and microcrystalline hydroxyapatite provides bioavailable calcium that your body can actually use. The D3 and K2 work synergistically to ensure the calcium is properly absorbed and deposited in bones rather than soft tissues. This all-in-one approach simplifies your supplement regimen while addressing bone health from multiple angles.

What Could Be Better: The calcium content means larger capsules and more pills per serving. Those only wanting D3 K2 may prefer a standalone formula.

Bottom Line: If you’re looking to comprehensively support bone health with all the key nutrients in one supplement, this formula delivers excellent value. The strategic combination of calcium, D3, and K2 ensures each nutrient can work to its full potential, making it particularly valuable for women concerned about osteoporosis or anyone at risk for bone density loss.

5. BioSchwartz Bone Strength Supplement – Gentle Non-Constipating Bone Health Support

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What We Like: BioSchwartz has specifically formulated this bone support supplement to avoid the constipation that plagues many calcium-based products. The gentle formula combines D3 and K2 with calcium in forms that are easy on the digestive system while maintaining high bioavailability. The comprehensive formulation supports bone density, strength, and overall skeletal health. Users consistently report excellent tolerance even with long-term use.

What Could Be Better: The gentle formulation means you may need multiple capsules daily to reach full dosing. The premium ingredients command a higher price point.

Bottom Line: For those who’ve struggled with digestive side effects from calcium supplements, BioSchwartz offers a game-changing solution. The non-constipating formula means you can consistently support your bone health without the unpleasant GI effects that often derail supplementation efforts.

6. Sports Research Vegan D3 + K2 with Coconut Oil

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What We Like: Sports Research delivers certified vegan D3 from lichen combined with MK-7 K2 from fermented chickpeas, all in coconut MCT oil for enhanced absorption. The 5000 IU of D3 with 100 mcg of K2 provides therapeutic dosing for serious supplementation. The Vegan Certified and Non-GMO Project Verified designations ensure ingredient integrity, while third-party testing validates quality and potency. The coconut oil base supports the absorption of these fat-soluble vitamins.

What Could Be Better: Softgels may be harder to swallow than capsules for some users. The coconut oil means those with coconut sensitivities should choose alternatives.

Bottom Line: Sports Research combines plant-based ethics with scientific formulation and rigorous quality standards. The coconut oil vehicle enhances bioavailability while the high-potency dosing makes this ideal for addressing deficiency or maintaining optimal levels in those with limited sun exposure.

7. Nature Made Vitamin D3 K2, 5000 IU Vitamin D for Bone, Teeth, Muscle and Immune Health

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What We Like: Nature Made’s trusted brand reputation backs this straightforward D3 K2 formula. Each softgel provides 5000 IU of vitamin D3 with 100 mcg of vitamin K2 for comprehensive bone, teeth, muscle, and immune support. The gluten-free formulation contains no synthetic dyes or artificial flavors. As one of the most recognized supplement brands, Nature Made offers reliability and consistent quality that many consumers trust for their daily health needs.

What Could Be Better: Nature Made uses conventional lanolin-sourced D3 rather than plant-based alternatives, making it unsuitable for vegans. The simple formula lacks the additional cofactors found in premium brands.

Bottom Line: For those who prioritize brand recognition and want a no-frills D3 K2 supplement from a household name, Nature Made delivers reliable quality at a reasonable price point. The straightforward formulation does what it promises without unnecessary additions, making it a solid choice for mainstream supplementation.

Comparison Table

Product	D3 Source	Dosage	Best For
NATURELO Vegan (60ct)	Lichen	5000 IU D3 + 100mcg K2	Vegan quality seekers
NATURELO (120ct)	Lichen	5000 IU D3 + 100mcg K2	Long-term value
D3 K2 Gummies	Not specified	2000 IU D3 + 100mcg K2	Pill-averse individuals
Calcium Complex	Not specified	D3 + K2 + Calcium	Comprehensive bone health
BioSchwartz	Not specified	D3 + K2 + Calcium	Sensitive stomachs
Sports Research	Lichen	5000 IU D3 + 100mcg K2	Certified vegan
Nature Made	Lanolin	5000 IU D3 + 100mcg K2	Brand trust

Why Take D3 and K2 Together?

The Calcium Paradox

Vitamin D3 increases calcium absorption from your diet—a crucial function for bone health. However, without adequate vitamin K2, this absorbed calcium may deposit in soft tissues like arteries and kidneys rather than bones. This creates the “calcium paradox” where people have both calcium-deficient bones AND calcium buildup in their cardiovascular system. K2 activates proteins that direct calcium to bones while preventing arterial calcification.

Enhanced Bone Mineralization

Vitamin K2 activates osteocalcin, a protein that binds calcium to your bone matrix, making bones stronger and denser. Without sufficient K2, osteocalcin remains inactive and cannot effectively incorporate calcium into bone tissue. Studies show that D3 and K2 together improve bone mineral density more effectively than either vitamin alone, particularly in postmenopausal women at highest risk for osteoporosis.

Cardiovascular Protection

While vitamin D3 supports cardiovascular health through various mechanisms, vitamin K2 specifically activates Matrix Gla Protein (MGP), which prevents calcium from accumulating in arterial walls. This dual action—D3 supporting heart muscle function and K2 preventing arterial calcification—creates comprehensive cardiovascular protection that extends beyond bone health benefits.

Optimal Dosing Ratio

Research suggests that for every 1000 IU of vitamin D3, you should take approximately 20 mcg of vitamin K2. This means a 5000 IU dose of D3 pairs well with 100 mcg of K2—the ratio found in most quality combination supplements. This balanced approach ensures both vitamins can work synergistically without one overwhelming the other.

Frequently Asked Questions

How much vitamin D3 and K2 should I take daily?

Most adults benefit from 2000-5000 IU of vitamin D3 daily, though some may need more based on blood test results showing deficiency. For vitamin K2, 100-200 mcg daily is generally recommended. Your healthcare provider should test your vitamin D levels (25-hydroxyvitamin D) and recommend appropriate dosing. Those with diagnosed deficiency may temporarily need higher doses under medical supervision.

What’s the difference between vitamin K1 and K2?

Vitamin K1 (phylloquinone) is found in leafy greens and primarily supports blood clotting. Vitamin K2 (menaquinone) has multiple subtypes with MK-4 and MK-7 being most common in supplements. K2 activates proteins involved in calcium metabolism and bone mineralization—functions that K1 doesn’t perform. MK-7 has a longer half-life and better bioavailability than MK-4, making it the preferred form for supplementation.

Can I take too much vitamin D3?

Yes, excessive vitamin D can cause hypercalcemia (too much calcium in blood), leading to nausea, weakness, kidney problems, and bone pain. The tolerable upper limit is 4000 IU daily for most adults, though some doctors prescribe higher doses for deficiency treatment. Regular blood testing ensures you maintain optimal levels (30-50 ng/mL) without overdoing it. Vitamin K2 helps mitigate some risks of excess D3 by properly directing calcium.

Should I take D3 K2 with or without food?

Both vitamins D3 and K2 are fat-soluble, meaning they absorb best when taken with dietary fat. Take your supplement with a meal containing healthy fats like avocado, nuts, olive oil, or fish. This significantly improves absorption compared to taking the supplement on an empty stomach. Some formulations include oil (like coconut MCT oil) to enhance absorption even without food.

Can vitamin K2 interfere with blood thinners?

Vitamin K2 can interfere with warfarin (Coumadin) and similar blood thinners that work by blocking vitamin K activity. However, K2 typically doesn’t affect newer anticoagulants like rivaroxaban or apixaban. If you’re on blood thinners, consult your doctor before supplementing with K2. Some patients on warfarin take consistent daily K2 doses while their doctor adjusts medication accordingly, but this requires professional supervision.

How long before I see benefits from D3 K2 supplementation?

Vitamin D blood levels typically improve within 2-3 months of consistent supplementation, with associated benefits like improved immune function appearing during this timeframe. Bone density improvements take longer—usually 6-12 months of consistent use before measurable changes appear on bone density scans. Many people report improved energy and mood within weeks of correcting vitamin D deficiency.

Is vitamin D3 from lichen as effective as from lanolin?

Yes, vitamin D3 from lichen (plant-based) is chemically identical to lanolin-derived D3 and absorbs just as effectively. Both are true D3 (cholecalciferol), not the less effective D2 (ergocalciferol). The only difference is the source—lichen is sustainable and vegan-friendly, while lanolin comes from sheep’s wool. Choose based on dietary preferences and ethics rather than effectiveness concerns.

Do I still need D3 K2 if I get sun exposure?

Sun exposure can provide vitamin D3, but factors like latitude, season, time of day, skin tone, sunscreen use, and age affect production significantly. Most people in northern climates don’t produce adequate D3 from sun alone, especially in winter. Vitamin K2 is rare in modern diets (found mainly in fermented foods like natto), so supplementation usually remains beneficial. Blood testing helps determine if your sun exposure provides sufficient D3.

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