Best David Sinclair Protocol Supplements (2026) – Top 10 Reviewed

Harvard longevity researcher Dr. David Sinclair has become one of the most influential voices in anti-aging science, and his personal supplement protocol has inspired millions to take a more proactive approach to healthy aging. If you’re looking to follow a research-backed longevity regimen based on Sinclair’s approach, these supplements deliver the key compounds he discusses taking daily, from NAD+ precursors to sirtuin activators and beyond.

Our Top Picks at a Glance

• Best NMN Formula: Renue By Science Liposomal NMN — 250mg pharmaceutical-grade
• Best NMN + Resveratrol Combo: 5-in-1 NAD+ Formula — Complete synergistic stack
• Best High-Dose NMN: Renue NMN Powder — 500mg per serving, 200 servings

Quick Comparison

Product	Key Ingredients	Form	Servings	Best For
Renue Liposomal NMN	250mg NMN (Liposomal)	Capsules	90	Premium NMN absorption
5-in-1 NAD+ Formula	500mg NR, Resveratrol, CoQ10, PQQ	Capsules	60	Complete Sinclair-style stack
Renue NMN Powder	500mg NMN per serving	Powder	200	High-dose NMN protocol
NR + Resveratrol	NR, Trans-Resveratrol	Capsules	60	Classic NAD+ & sirtuin combo
Resveratrol 1000mg	1000mg Resveratrol Complex	Capsules	90	High-dose resveratrol
NAD+ Resveratrol Complex	1000mg NAD+, Resveratrol	Capsules	60	Premium synergistic formula
Alpha Lipoic Acid 600mg	600mg ALA	Capsules	60	Metabolic support
ZEBORA CoQ10 Plus	400mg CoQ10, PQQ, Omega-3	Softgels	120	Mitochondrial health
Renue SLC NMN	250mg NMN (Enteric)	Capsules	200	Extended NMN supply

1. Renue By Science Liposomal NMN — Best Premium NMN

→ Check Price on Amazon

This pharmaceutical-grade liposomal NMN delivers 250mg per capsule with superior absorption technology that mirrors Sinclair’s emphasis on bioavailability.

Sinclair takes 1 gram of NMN daily mixed with yogurt for fat-enhanced absorption. This liposomal formula achieves similar bioavailability enhancement without requiring dietary fat, making it more convenient for those following Sinclair’s protocol. The 90-capsule supply provides three months at the commonly used 250mg dose or 22 days at Sinclair’s full 1 gram daily intake.

What We Like

• Liposomal technology maximizes NMN absorption
• Pharmaceutical-grade purity for reliable results
• Convenient capsule form requires no mixing
• 250mg per capsule allows flexible dosing
• Manufactured to rigorous quality standards

What Could Be Better

• Premium pricing reflects advanced formulation
• Requires 4 capsules daily to match Sinclair’s 1g dose

Bottom Line: For those seeking the highest-quality NMN to follow Sinclair’s protocol with enhanced bioavailability, this liposomal formula delivers pharmaceutical-grade NAD+ support.

2. 5-in-1 NAD+ Formula — Best Complete Sinclair-Style Stack

→ Check Price on Amazon

This comprehensive formula combines 500mg NR with resveratrol, CoQ10, and PQQ to replicate Sinclair’s multi-compound approach in one convenient supplement.

Sinclair emphasizes that NMN and resveratrol work synergistically—NMN provides the fuel (NAD+) while resveratrol activates the sirtuins that depend on NAD+. This formula delivers both along with CoQ10 for mitochondrial support, matching the core of Sinclair’s daily regimen without requiring multiple separate bottles.

What We Like

• 500mg NR provides substantial NAD+ precursor
• Includes resveratrol for sirtuin activation per Sinclair’s approach
• CoQ10 and PQQ support mitochondrial function
• Eliminates need for multiple supplements
• Research-backed combination of synergistic compounds

What Could Be Better

• NR instead of NMN (though both raise NAD+ effectively)
• Individual ingredient doses lower than Sinclair’s high amounts

Bottom Line: For those wanting a complete Sinclair-inspired stack in one formula, this combination delivers the key compounds he emphasizes without the complexity of sourcing each separately.

3. Renue NMN Fast-Dissolve Powder — Best for Sinclair’s Full Protocol

→ Check Price on Amazon

This 100g powder delivers 200 servings of 500mg NMN, allowing you to easily reach Sinclair’s 1 gram daily dose by mixing with yogurt as he does.

Sinclair specifically mentions taking his NMN powder mixed in yogurt each morning, and this fast-dissolve formula replicates that exact approach. The powder format provides exceptional value with 200 servings, and the ability to measure custom doses lets you start at 250-500mg and work up to Sinclair’s full 1 gram protocol.

What We Like

• 500mg per serving matches Sinclair’s dosing approach
• Powder format allows mixing with yogurt per his protocol
• 200 servings provide 6+ month supply at 500mg dose
• Fast-dissolve formula for easy consumption
• Excellent value compared to capsule formulations

What Could Be Better

• Requires measuring for accurate dosing
• Less convenient for travel than capsules
• Must be stored properly to maintain potency

Bottom Line: For those committed to following Sinclair’s exact NMN protocol with yogurt consumption, this powder delivers pharmaceutical-grade NMN at exceptional value.

4. NR + Resveratrol — Best Research-Backed Combination

→ Check Price on Amazon

This classic combination pairs NR with trans-resveratrol to deliver the synergistic NAD+ and sirtuin support that forms the foundation of Sinclair’s approach.

Sinclair emphasizes that resveratrol and NAD+ precursors work together—he describes resveratrol as the “accelerator pedal” for sirtuin enzymes and NMN/NR as the “fuel” they need. This formula provides both in a simple two-compound stack backed by extensive clinical research.

What We Like

• Synergistic combination backed by Sinclair’s research
• NR provides reliable NAD+ elevation
• Trans-resveratrol activates sirtuins
• Simple formula without unnecessary additions
• Extensive clinical data supports both compounds

What Could Be Better

• Doses may be lower than Sinclair’s personal intake
• Doesn’t include CoQ10 or other supplements he takes

Bottom Line: For those who want to start with the core of Sinclair’s approach—NAD+ support plus sirtuin activation—this proven combination delivers the essential synergistic benefits.

5. Resveratrol 1000mg Max Strength — Best High-Dose Resveratrol

→ Check Price on Amazon

This maximum-strength formula delivers 1000mg of resveratrol per serving, matching Sinclair’s daily dose for sirtuin activation.

Sinclair takes 1 gram of resveratrol each morning mixed with yogurt alongside his NMN. He emphasizes taking resveratrol with fat for proper absorption, as it’s a hydrophobic molecule that doesn’t dissolve well in water. This high-potency formula provides the full dose he recommends with 180 capsules offering 90 days of supply.

What We Like

• Full 1000mg dose matches Sinclair’s protocol
• Natural trans-resveratrol for bioactivity
• 90-day supply for long-term use
• Can be taken with yogurt or healthy fats
• Excellent value per serving

What Could Be Better

• Requires separate NMN supplement
• Must be taken with fat source for absorption

Bottom Line: For those building their own Sinclair-style protocol with high-dose resveratrol as a foundation, this potent formula delivers the exact amount he takes daily.

6. NAD+ Resveratrol Complex 1000mg — Best Premium Synergistic Formula

→ Check Price on Amazon

This premium complex combines 1000mg NAD+ precursors with trans-resveratrol for comprehensive implementation of Sinclair’s core protocol principles.

The high-potency approach delivers generous doses of both compounds Sinclair emphasizes most: NAD+ support for cellular energy and DNA repair, plus resveratrol for sirtuin activation. This eliminates the need to source and dose two separate supplements while ensuring adequate amounts of each.

What We Like

• High 1000mg NAD+ precursor dose
• Trans-resveratrol included for synergy
• Premium formulation quality
• Convenient all-in-one approach
• Addresses both key Sinclair pathways

What Could Be Better

• Premium pricing reflects high doses
• Less flexibility than separate supplements

Bottom Line: Users seeking premium-quality implementation of Sinclair’s core NAD+ and resveratrol protocol in one convenient formula will appreciate this high-potency combination.

7. Alpha Lipoic Acid 600mg — Best Metabolic Support

→ Check Price on Amazon

Sinclair has mentioned taking alpha-lipoic acid for its unique antioxidant and metabolic benefits that complement his NAD+ protocol.

This versatile compound works in both water and fat-soluble environments, providing comprehensive antioxidant protection while supporting glucose metabolism and mitochondrial function. At 600mg, this therapeutic dose aligns with amounts used in metabolic health research and complements the cellular energy focus of NMN and resveratrol.

What We Like

• 600mg therapeutic dose for metabolic support
• Works in both water and fat environments
• Supports glucose regulation and energy metabolism
• Regenerates other antioxidants
• Complements NAD+ precursors effectively

What Could Be Better

• Best absorbed on empty stomach
• Single ingredient requires combining with other supplements

Bottom Line: For those building a comprehensive Sinclair-inspired stack, alpha-lipoic acid provides unique metabolic and antioxidant benefits that work synergistically with NAD+ support.

8. ZEBORA CoQ10 400mg Plus — Best Mitochondrial Support

→ Check Price on Amazon

Sinclair has mentioned taking CoQ10 for mitochondrial support, and this formula combines 400mg with PQQ and omega-3s for comprehensive cellular energy benefits.

CoQ10 plays a critical role in mitochondrial energy production and declines significantly with age. Combined with PQQ for mitochondrial biogenesis and omega-3s for anti-inflammatory support, this addresses multiple aspects of the cellular health Sinclair emphasizes. BioPerine enhances absorption of all ingredients.

What We Like

• High 400mg CoQ10 dose for mitochondrial support
• PQQ promotes new mitochondria growth
• Omega-3s provide cardiovascular benefits
• BioPerine enhances bioavailability
• 120-serving supply for extended use

What Could Be Better

• Softgel format less flexible than capsules
• Focuses on mitochondrial rather than NAD+ pathway

Bottom Line: For those following Sinclair’s emphasis on mitochondrial health alongside NAD+ support, this comprehensive CoQ10 formula delivers multiple complementary benefits.

9. Renue SLC Enteric NMN — Best Extended-Release NMN

→ Check Price on Amazon

This enteric-coated NMN formula delivers 250mg per capsule with 200 capsules providing extended supply for consistent protocol adherence.

The SLC (Sublingual Cellular) technology with enteric coating protects NMN through stomach acid, ensuring it reaches the intestines intact for optimal absorption. With 200 capsules, this provides 50 days at Sinclair’s 1 gram dose or over 6 months at the commonly used 250mg maintenance dose.

What We Like

• Enteric coating protects NMN through digestion
• 200-capsule supply reduces reordering frequency
• 250mg per capsule allows flexible dosing
• Pharmaceutical-grade quality
• Excellent value for extended use

What Could Be Better

• Enteric coating increases cost over standard capsules
• Requires 4 capsules for Sinclair’s full 1g dose

Bottom Line: For those committed to long-term NMN supplementation following Sinclair’s approach, this enteric-coated formula with extended supply offers convenience and protection.

Understanding David Sinclair’s Longevity Philosophy

Sinclair’s approach to longevity centers on his Information Theory of Aging, which proposes that aging results from cells losing their ability to read the correct genes at the right time—essentially an epigenetic problem rather than DNA damage itself. This theory guides his supplement choices: he focuses on compounds that restore cellular function by supporting NAD+ levels, activating sirtuins (the “readers” of our genetic information), and promoting cellular maintenance and repair mechanisms.

The foundation of Sinclair’s supplement protocol rests on the synergistic relationship between NMN and resveratrol. He describes this partnership with a simple analogy: resveratrol acts as the “accelerator pedal” for sirtuin genes, while NMN serves as the “fuel” those sirtuins need to function. Without adequate NAD+ (which NMN provides), sirtuins cannot perform their DNA repair and maintenance functions effectively. Conversely, activating sirtuins without sufficient NAD+ to power them limits their beneficial effects. This explains why Sinclair takes both compounds together each morning.

Sinclair emphasizes the importance of bioavailability and proper supplementation timing. He takes his NMN and resveratrol mixed with yogurt specifically because resveratrol is hydrophobic (doesn’t dissolve in water) and requires fat for proper absorption. His research showed that without fat, resveratrol absorption dropped five-fold. He stores NMN in the freezer to maintain stability and takes it first thing in the morning to support cellular energy throughout the day. These practical details matter as much as choosing the right compounds.

Beyond supplements, Sinclair’s longevity protocol includes significant lifestyle components that work synergistically with his supplementation. He practices intermittent fasting and caloric restriction, often eating just one meal per day to activate AMPK and autophagy pathways. He exercises regularly, combining cardiovascular work with strength training, though he notes taking metformin on non-workout days to avoid potentially blunting exercise adaptations. He prioritizes sleep quality and maintains consistent sleep-wake cycles. These lifestyle factors create the foundation upon which supplements provide additional benefits.

Sinclair tracks his progress through regular biomarker testing including inflammatory markers, metabolic panels, and comprehensive health assessments. He reports that his blood work resembles that of someone decades younger, though he acknowledges these are anecdotal results from a single individual. His approach emphasizes that supplements work best as part of a comprehensive longevity strategy rather than as standalone interventions. The goal isn’t just adding years to life but maintaining vitality, cognitive function, and physical capability throughout an extended healthspan.

The Complete David Sinclair Protocol Breakdown

Sinclair’s core daily supplements as of 2025 include 1 gram of NMN taken in the morning, often mixed with yogurt. He switched to NMN from nicotinamide riboside (NR) based on unpublished research showing NMN improved exercise capacity by 50% in mice while NR showed no effect at the same dose. He prefers NMN because it converts to NAD+ in just one step, potentially making it more efficient than NR which requires an additional conversion step.

Resveratrol at 1 gram daily forms the second pillar of his protocol, taken alongside NMN with yogurt for enhanced absorption. Despite mixed human research results and reproducibility issues with some early studies, Sinclair maintains that resveratrol’s sirtuin-activating properties make it valuable when combined with NAD+ support. The dose he uses is significantly higher than what you’d get from dietary sources—achieving 1 gram of resveratrol would require drinking roughly 170 bottles of red wine daily.

Metformin represents Sinclair’s approach to mimicking caloric restriction pharmacologically. He takes 800-1000mg in the evening, though recent updates indicate he’s partially switched to berberine (1g) because metformin caused digestive discomfort. Both compounds activate AMPK, improve insulin sensitivity, and may provide longevity benefits by putting cells into a protective mode. Importantly, Sinclair skips metformin on workout days based on research suggesting it might blunt the mitochondrial adaptations normally gained from exercise.

Additional supplements in Sinclair’s stack include vitamin D3 (at least 2000 IU daily) and vitamin K2 for bone health and calcium regulation, fish oil for omega-3 fatty acids and cardiovascular support, alpha-lipoic acid (around 300-500mg) for its unique antioxidant properties, CoQ10 for mitochondrial function, fisetin (500mg) as a senolytic to clear senescent cells, spermidine (1-2mg) to promote autophagy and cellular renewal, and low-dose aspirin (81mg) despite mixed evidence on cardiovascular benefits, citing potential cancer risk reduction.

Sinclair has also mentioned taking a statin (80mg) for cholesterol management, though he’s noted family history of cardiovascular issues as a factor in this decision. He experimented with rapamycin (about 4 times per year) for its mTOR-inhibiting and autophagy-promoting effects, though this is used intermittently rather than daily. He’s also mentioned trimethylglycine (TMG) to provide methyl groups that get used up when the body processes nicotinamide, a byproduct of NAD+ metabolism, though recent updates suggest he may have stopped taking this regularly.

Frequently Asked Questions

Should I take the same doses as David Sinclair?

Sinclair’s doses (1g NMN, 1g resveratrol) are relatively high compared to many clinical studies, which often use 250-500mg of each compound. His approach reflects his philosophy of aggressive anti-aging intervention, but most people can likely benefit from lower doses, especially when starting out. Begin with 250-500mg of NMN or NR and 100-500mg of resveratrol, then increase gradually if desired and tolerated. Remember that Sinclair’s regimen represents his personal approach based on his research—it’s not a universal prescription.

Why does Sinclair prefer NMN over NR?

Sinclair favors NMN based on unpublished research from his lab showing NMN boosted exercise capacity in mice by 50% while NR had no effect at the same dose. He also notes that NMN converts to NAD+ in one step using a specific transporter, potentially making it more efficient than NR which requires conversion to NMN first. However, both compounds effectively raise NAD+ levels in humans, and NR has more extensive published human clinical trial data. The practical differences may be smaller than the mechanistic differences suggest.

Do I really need to take resveratrol with fat like Sinclair does?

Yes, this is important for absorption. Resveratrol is lipophilic (fat-loving) and poorly absorbed without dietary fat. Sinclair’s research showed that taking resveratrol without fat reduced absorption by five-fold compared to taking it with yogurt or another fat source. You don’t need to make your own yogurt as he does—any source of healthy fat (olive oil, nuts, avocado, coconut oil) taken with resveratrol will improve bioavailability. Some supplements use micronized or liposomal resveratrol to improve absorption without requiring dietary fat.

Can I follow Sinclair’s protocol if I’m taking prescription medications?

You must consult your doctor before combining Sinclair’s protocol with prescription medications. Resveratrol may enhance blood thinner effects, metformin obviously shouldn’t be taken without medical supervision and can interact with other diabetes medications, and NMN may affect blood sugar levels requiring adjustment of diabetes drugs. Alpha-lipoic acid can lower blood sugar, and fish oil may increase bleeding risk with anticoagulants. Always inform your healthcare provider about all supplements before starting this or any longevity protocol.

How much does it cost to follow David Sinclair’s complete protocol?

Following Sinclair’s full protocol costs approximately $150-400+ monthly depending on supplement brands and quality. The bulk of the cost comes from high-dose NMN ($50-150/month for 1g daily) and resveratrol ($30-80/month for 1g daily). Additional supplements like CoQ10, fish oil, vitamins, and others add $50-100+ monthly. You can reduce costs significantly by starting with just the core NMN and resveratrol at lower doses, using powder formulations instead of capsules, or choosing quality but value-priced brands.

Should I take metformin like Sinclair even though I’m not diabetic?

Metformin is a prescription medication that should only be taken under medical supervision, even for off-label anti-aging use. While some doctors prescribe metformin for longevity purposes in healthy individuals, it can cause digestive side effects and may reduce vitamin B12 levels over time. Sinclair himself has largely switched to berberine (available without prescription) because metformin bothered his stomach. Berberine activates similar AMPK pathways with potentially fewer side effects. Discuss with your doctor whether metformin or berberine might be appropriate for your situation.

What lifestyle changes should I make alongside Sinclair’s supplements?

Sinclair emphasizes that supplements work best as part of comprehensive lifestyle optimization. He practices intermittent fasting and caloric restriction (often one meal per day), exercises regularly combining cardio and strength training, prioritizes 7-8 hours of quality sleep with consistent timing, manages stress through meditation and mindfulness, limits sugar and refined carbohydrates strictly, and tracks biomarkers through regular blood testing. These lifestyle factors likely contribute more to his results than supplements alone. Start with foundational habits before adding extensive supplementation.

How long before I see results from following Sinclair’s protocol?

Energy improvements from NAD+ support typically appear within 2-4 weeks of consistent supplementation. Sleep quality and physical performance may improve within 4-8 weeks. More profound markers of biological aging—reduced inflammatory markers, improved metabolic panels, enhanced DNA repair—require 6-12 months to measure objectively. Sinclair reports his blood work resembles someone decades younger, but these results developed over years of consistent protocol adherence. Approach this as a long-term investment in healthspan rather than expecting rapid transformation.

Is Sinclair’s protocol safe for long-term use?

Most components of Sinclair’s protocol (NMN, resveratrol, vitamins, fish oil, CoQ10) have good safety profiles in clinical studies with minimal side effects when used at recommended doses. However, long-term human data beyond a few years is limited for high-dose NMN and resveratrol. Metformin has extensive long-term safety data in diabetics but less in healthy individuals using it for longevity. The senolytic fisetin and mTOR inhibitor rapamycin have less human data and should be approached more cautiously. Work with a healthcare provider familiar with longevity medicine to monitor biomarkers and adjust your protocol as needed.

Related Articles

• Best NMN & NAD+ Supplements for Longevity
• Best Resveratrol Supplements
• Best Alpha Lipoic Acid Supplements
• Best CoQ10 Supplements
• Best Mitochondria Support Supplements