Best DGL Licorice Supplements (2026) – Top 10 Reviewed
Deglycyrrhizinated licorice (DGL) is a specially processed form of licorice root that has had the glycyrrhizin component removed, making it safer for long-term use while preserving the digestive health benefits that licorice has offered for centuries. This modified extract provides gentle, natural support for the stomach lining and digestive tract without the potential side effects associated with regular licorice, such as elevated blood pressure or potassium imbalances. Whether you’re seeking relief from occasional digestive discomfort or looking to support your gastrointestinal health, finding the right DGL supplement can make a meaningful difference in your digestive wellness journey.
Our Top Picks at a Glance
- Best Overall: Natural Factors DGL Chewable – trusted formula with optimal dosing
- Best Value: Carlyle DGL Capsules – high-potency equivalent at budget price
- Best Chewable: Nature’s Way DGL – convenient chewable with pleasant flavor
Quick Comparison
| Product | DGL Dose | Form | Servings | Best For |
|---|---|---|---|---|
| Natural Factors DGL | 400mg | Chewable | 180 | Traditional chewable |
| Carlyle DGL | 400mg (4000mg equiv) | Capsules | 100 | High potency value |
| Nature’s Way DGL | 400mg | Chewable | 100 | Pleasant taste |
| Designs for Health | 500mg | Chewable | 45 | Premium quality |
| Nature’s Way DGL Ultra | 75mg GutGard | Capsules | 90 | Capsule convenience |
| Nutrissence DGL | 380mg | Capsules | 200 | Extended supply |
| Nutricost DGL | 500mg (5000mg equiv) | Capsules | 120 | Concentrated extract |
| Vitacost DGL | 750mg | Capsules | 100 | High potency |
| Vital Nutrients Powder | 300mg per serving | Powder | 400 | Flexible dosing |
| Pure Encapsulations Plus | 300mg | Capsules | 60 | Herbal blend |
1. Natural Factors DGL Chewable – Best Overall
- Natural DGL Supplement Formula: Our DGL supplement with licorice extract is specially crafted to support digestion and stomach health.
- Gentle Digestive Aid: These chewable tablets support the integrity of the natural mucosal lining of the stomach and intestinal wall
- Digestive Health Support: To support gut health, chew 1 tablet 1-3 times per day 20 minutes before each meal or as directed by a health professional
- Vegan Dietary Supplement: This licorice root extract supplement is free from dairy, sugar, wheat, gluten, yeast, soy, egg, fish, shellfish, salt, tree nuts, and GMOs
- About Natural Factors: Natural Factors is a family-owned B-Corp, Carbon Neutral, and 3rd Party with direct ownership of all manufacturing stages to ensure the highest quality supplements
Natural Factors DGL Chewable stands as the gold standard for deglycyrrhizinated licorice supplementation, offering a well-researched dosage in a pleasant-tasting chewable tablet.
Each chewable tablet provides 400mg of deglycyrrhizinated licorice root extract, combined with 55mg of anise seed powder and a touch of stevia for natural sweetness. The 180-tablet bottle provides up to 60 days of support at the maximum recommended dosage of three tablets daily. The tablets are designed to be chewed 20 minutes before each meal, allowing the DGL to coat and soothe the digestive tract effectively.
What We Like
- 400mg per tablet provides clinically-studied dosage
- 180 tablets offer excellent value and extended supply
- Pleasant licorice-anise flavor makes supplementation enjoyable
- Chewable format allows DGL to coat stomach lining effectively
- Non-GMO and gluten-free formulation
What Could Be Better
- Contains xylitol which may cause digestive upset in sensitive individuals
- Chewable tablets less convenient than swallowable capsules for some
Bottom Line: Natural Factors DGL Chewable delivers time-tested digestive support in a pleasant-tasting format that maximizes effectiveness through direct contact with the stomach lining.
2. Carlyle DGL Deglycyrrhizinated Licorice – Best Value
- DGL LICORICE: Chinese traditional herb highly known for its powerful plant compunds
- VEGETARIAN FORMULA: Vegetarian capsules feature Licorice in each serving
- ROOTED IN WELLNESS: Carlyle provides premium, honest supplements in your pursuit to healthy living
- CARLYLE MANUFACTURERS: Laboratory Tested, Trusted Ingredients, Superior Quality, 100% Guaranteed!
- NATURALLY FREE OF: Gluten, Wheat, Yeast, Lactose, Soy, Artificial Flavor, Preservatives & Non-GMO
Carlyle offers exceptional value with their high-potency DGL capsules, delivering a 4,000mg licorice equivalent from concentrated 10:1 extract at an affordable price point.
Each serving of two vegetarian capsules provides 400mg of DGL extract standardized to a 10:1 ratio, equivalent to 4,000mg of licorice root. The 200-capsule bottle provides 100 servings, making it one of the most economical options available. The capsules are vegetarian, non-GMO, and free from gluten and artificial preservatives.
What We Like
- 10:1 extract concentration provides powerful support
- 200 capsules offer exceptional value at 100 servings
- Vegetarian capsules suitable for various dietary preferences
- Non-GMO and gluten-free formulation
- Manufactured with rigorous quality standards
What Could Be Better
- Two capsules daily required for full dose
- Capsule form doesn’t coat stomach lining like chewables
Bottom Line: Carlyle DGL Deglycyrrhizinated Licorice delivers concentrated digestive support at an unbeatable price, perfect for budget-conscious consumers seeking long-term supplementation.
3. Nature’s Way DGL Chewable – Best Chewable
- Nature's Way DGL is a gut support supplement formulated to provide soothing digestive relief.*
- With clinically studied GutGard DGL for occasional stomach upset.* Less than 1% glycyrrhizin to help avoid any potential effect on blood pressure.*
- Adults chew 3 tablets after food in the morning; chew 3 tablets after food in the evening
- Gluten-free and vegan. No wheat, soy, dairy, gelatin, and artificial colors.
- At Nature's Way, we believe nature is the ultimate problem solver. For over 50 years, we have looked to the natural world for inspiration. Our quality vitamins and supplements are formulated to help you find your way to wellness
Nature’s Way provides a pleasant-tasting DGL chewable tablet that combines effective digestive support with a flavor profile that makes supplementation enjoyable.
Each tablet delivers 400mg of deglycyrrhizinated licorice extract with a licorice flavor that’s naturally sweet without being overwhelming. The recommended dosage is two tablets chewed 20 minutes before each meal. The 100-tablet bottle provides approximately 16 days of supply at maximum dosage or longer at reduced frequency.
What We Like
- Pleasant licorice flavor enhances compliance
- 400mg per tablet provides effective dosing
- Chewable format allows direct coating of digestive tract
- Trusted Nature’s Way quality and reputation
- Free from gluten, salt, wheat, and artificial ingredients
What Could Be Better
- Contains 1g added sugars per serving
- 100 tablets provide shorter supply than some competitors
Bottom Line: Nature’s Way DGL Chewable offers effective digestive support in a pleasant-tasting format backed by over 50 years of supplement manufacturing expertise.
4. Designs for Health DGL Synergy – Premium Quality
- Supports Gastric Mucosa - DGL (Glycyrrhiza glabra) root extract is well-recognized for its healing effects on the gastric mucosa. Licorice is a mucilaginous herb that coats and soothes inflamed gastric and intestinal tissue. With its very low glycyrrhizin content, DGL works efficaciously without some of the potential side effects of prolonged high-dose full-spectrum licorice, including hypertension, hypokalemia (low blood potassium levels) and fluid retention. *
- Support for Dyspepsia - DGL Synergy is a pleasant-tasting, chewable formula of deglycyrrhizinated licorice (DGL), to help with dyspepsia. *
- Contains a Standardized Form - The formula contains a standardized, high-quality form of DGL, the amino acid glycine, and calcium in the form of calcium glycerophosphate. *
- Higher Standards. Better Results - Designs for Health maintains a strict, no-compromises approach to quality raw material selection. We never cut corners with substandard ingredients. This product is Non-GMO, Gluten-Free, and Vegetarian-friendly.
- Clinically-Trusted Care - DFH is the #1 practitioner supplement brand recommended by functional medicine professionals and the #1 practitioner supplement brand personally trusted by functional medicine professionals.**
Designs for Health delivers a pharmaceutical-grade DGL formula enhanced with glycine and calcium, creating a synergistic blend for comprehensive digestive support.
Each serving of two chewable tablets provides 500mg of standardized deglycyrrhizinated licorice extract, plus glycine and calcium glycerophosphate for enhanced mucosal support. The formula is sugar-free and uses a pleasant-tasting formulation. The 90-tablet bottle provides 45 servings, designed to be chewed before meals.
What We Like
- 500mg standardized DGL extract per serving
- Enhanced with synergistic glycine and calcium
- Sugar-free formula with pleasant taste
- Pharmaceutical-grade quality trusted by healthcare practitioners
- Non-GMO ingredients with minimal excipients
What Could Be Better
- Premium quality reflects in higher price point
- 90 tablets provide limited supply at recommended dosage
Bottom Line: Designs for Health DGL Synergy represents premium digestive support with pharmaceutical-grade quality and synergistic ingredients for enhanced effectiveness.
5. Nature’s Way DGL Ultra – Capsule Convenience
- Extra strength formula as compared to DGL, for digestive relief.* ** **As compared to DGL.
- With deglycyrrhiziniated licorice extract formulated with Gutgard for soothing digestive relief.*
- Contains less than 1% glycyrrhizin to help avoid any potential effect on blood pressure.
- Gluten-free and vegan. No salt, yeast-derived ingredients, wheat, corn, soy, dairy, or artificial colors, flavors, or preservatives.
- Bottle made with 97% post-consumer recycled materials. Please recycle.
Nature’s Way DGL Ultra features the patented GutGard deglycyrrhizinated licorice extract in convenient capsule form, perfect for those who prefer swallowable supplements.
Each vegan capsule provides 75mg of GutGard DGL root extract, a specialized form with enhanced bioavailability. The recommended dosage is one capsule after food in the morning and one in the evening. The 90-capsule bottle provides 45 days of support. The formula is completely vegan with no gluten, dairy, soy, or artificial additives.
What We Like
- Features patented GutGard DGL extract
- Convenient capsule form for easy supplementation
- 100% vegan with clean ingredient profile
- 90 capsules provide 45-day supply
- Free from all major allergens and artificial ingredients
What Could Be Better
- Lower dose per capsule compared to chewable options
- Capsules don’t provide direct coating action of chewables
Bottom Line: Nature’s Way DGL Ultra delivers patented GutGard extract in a convenient vegan capsule for those seeking simple, effective digestive support.
6. Nutrissence DGL Licorice – Extended Supply
- Promotes Digestive Wellness: Supports healthy digestive function
- Gentle & Secure: Milder and safer option for long-term use
- Easy to Take: Convenient capsule form
- Purity Assured: No preservatives and no GMOs
- Proudly Made in the USA
Nutrissence provides exceptional value with 200 capsules of 380mg DGL extract, offering the longest supply of any capsule-based product in this category.
Each capsule contains 380mg of deglycyrrhizinated licorice root extract in a convenient capsule form that’s easier to take than chewable tablets. The 200-capsule bottle provides up to 200 days of support at one capsule daily or 100 days at the higher two-capsule daily dosage. The formula is manufactured in the USA with quality ingredients.
What We Like
- 200 capsules provide exceptional extended supply
- 380mg per capsule offers solid dosing
- Convenient capsule form more portable than chewables
- Manufactured in USA with quality standards
- Milder form suitable for long-term use
What Could Be Better
- Capsule format doesn’t coat digestive tract like chewables
- Basic formula without additional synergistic ingredients
Bottom Line: Nutrissence DGL Licorice offers the longest supply and excellent convenience for those preferring capsule-based digestive support over chewable formats.
7. Nutricost DGL Extract – Concentrated Formula
- Potent Extract: Each serving of Nutricost's DGL Capsules delivers 5,000mg equivalent from 500mg of 10:1 extract per serving, offering a concentrated dose of its beneficial components.
- Abundant Supply: With 120 capsules per bottle, you have a generous 120 servings available to support your daily wellness routine effectively.
- Certified Facility: Manufactured in an NSF Certified GMP Compliant facility, these capsules adhere to strict quality standards, ensuring product integrity and safety.
- Third-Party Testing: Each batch undergoes rigorous third-party testing by independent ISO-accredited laboratories, verifying the potency and purity of the product.
- Trusted Quality Assurance: Nutricost prioritizes transparency and quality assurance, providing you with a reliable source of DGL extract backed by comprehensive testing and manufacturing standards.
Nutricost delivers a concentrated 10:1 DGL extract providing 5,000mg licorice equivalent from just 500mg of extract per serving.
Each vegan capsule provides 500mg of 10:1 DGL extract, equivalent to 5,000mg of licorice root. The 120-capsule bottle provides a full 120 days of support at one capsule daily. Manufactured in an NSF-certified GMP facility, each batch undergoes rigorous third-party testing by ISO-accredited laboratories to verify potency and purity.
What We Like
- 10:1 concentrated extract provides enhanced potency
- 120 capsules offer four months of support
- Third-party tested for quality and purity
- Vegan, non-GMO, and gluten-free formulation
- Excellent value for concentrated formula
What Could Be Better
- Single capsule daily may provide less support than multiple doses
- Higher concentration may be more than some users need
Bottom Line: Nutricost DGL Extract delivers concentrated digestive support with rigorous third-party testing, perfect for those seeking potent supplementation with verified quality.
8. Vitacost DGL Extract – High Potency
Vitacost provides a high-potency DGL formula delivering 750mg of deglycyrrhizinated licorice root extract per capsule at an affordable price.
Each easy-to-swallow capsule contains 750mg of DGL extract with less than 3% glycyrrhizic acid per serving, ensuring safety for long-term use. The formula is free from added sugars and artificial sweeteners. The 100-capsule bottle provides over three months of support at one capsule daily.
What We Like
- 750mg high-potency dose per capsule
- Sugar and artificial sweetener free
- Less than 3% glycyrrhizic acid ensures safety
- 100 servings provide excellent value
- Easy-to-swallow capsules for convenience
What Could Be Better
- Higher potency may be excessive for some users
- Capsule form doesn’t provide chewable coating benefits
Bottom Line: Vitacost DGL Extract delivers superior high-potency digestive support at an excellent value, ideal for those seeking maximum strength in convenient capsule form.
9. Vital Nutrients DGL Powder – Flexible Dosing
- Herbal DGL Supplement for Healthy Gastrointestinal Tract Tissue Support: Vital Nutrients DGL Powder soothes, supports, and protects the GI mucus membrane and may help promote regularity of bowel movements*
- Safe and Effective Deglycyrrhized Licorice Root: Our DGL supplement has been specially processed to have the glycyrrhizin component removed to below .6% to avoid potential side effects*
- Clean Vegan Formula. Hypoallergenic and Non-GMO. Made without artificial fillers, coatings, binders, or colors.
- Quality You Can Rely on: Our rigorous quality assurance program includes third-party independent laboratory testing of raw ingredients and finished products for purity and potency to ensure what’s on the label is in the bottle.
- Trusted by Healthcare Practitioners Worldwide: Vital Nutrients was founded 30 years ago by practitioners who set out to make a positive and lasting impact on the health of people and planet. Today, our premium line of clinically relevant, pure, clean-label formulas is trusted by healthcare practitioners and health-conscious consumers worldwide
Vital Nutrients offers DGL in a pure powder form, allowing flexible dosing and the longest supply of any product in this category.
Each 1/8 teaspoon serving provides 300mg of deglycyrrhizinated licorice powder from Glycyrrhiza glabra root. The 120g container provides approximately 400 servings, making it the most economical option per dose. The powder can be mixed with water or taken directly, and the recommended usage is 1/8 teaspoon three times daily after meals and at bedtime.
What We Like
- 400 servings provide exceptional value and supply
- Flexible dosing allows customization to individual needs
- Pure powder form with minimal processing
- Vegan formula free from all major allergens
- Manufactured in NSF-certified facility with rigorous testing
What Could Be Better
- Powder requires mixing or measuring for each dose
- Less convenient than pre-dosed capsules or tablets
Bottom Line: Vital Nutrients DGL Powder provides the ultimate flexibility and value for those willing to measure doses, offering pure digestive support with exceptional supply.
10. Pure Encapsulations DGL Plus – Herbal Blend
- Gut Health Support for All: Pure Encapsulations DGL Plus provides nutritional support for a healthy stomach lining and gastrointestinal tract*
- Herbal Blend: Our formula combines deglycyrrhizinated licorice (DGL) with herbal extracts like aloe vera and marshmallow root as well as slippery elm bark
- Vegan & Gluten Free: Made with the highest quality vegan ingredients, our DGL Plus is free from gluten, providing helpful digestive health*
- Suggested Use: As a dietary supplement, take 1 capsule daily, before a meal, or as directed by a health professional
- Pure Difference: What we leave out matters, too; Pure Encapsulations products are FREE FROM common allergens, artificial or unnecessary ingredients, and GMOs
Pure Encapsulations combines 300mg of DGL with complementary herbal extracts including aloe vera, marshmallow root, and slippery elm for comprehensive digestive support.
Each vegetarian capsule provides 300mg deglycyrrhizinated licorice extract along with 200mg marshmallow root extract, 100mg slippery elm bark powder, and 50mg aloe vera extract. This synergistic blend provides multi-faceted support for the gastrointestinal tract. The 60-capsule bottle provides a two-month supply at one capsule daily before meals.
What We Like
- Comprehensive herbal blend enhances digestive support
- 300mg DGL combined with soothing botanical extracts
- Vegan and gluten-free formulation
- Free from common allergens and GMOs
- Pure Encapsulations quality with minimal excipients
What Could Be Better
- Premium herbal blend comes at higher price point
- 60 capsules provide limited supply
Bottom Line: Pure Encapsulations DGL Plus offers comprehensive digestive support by combining DGL with synergistic herbal extracts for enhanced gastrointestinal wellness.
How to Choose the Best DGL Licorice Supplement
When selecting a DGL licorice supplement, understanding the key factors that distinguish quality products will help you make an informed decision that best supports your digestive health goals.
The form of DGL you choose significantly impacts both convenience and effectiveness. Chewable tablets are traditionally recommended because they allow the DGL to directly coat the stomach lining and esophagus as you chew them, potentially providing more targeted support. However, capsules offer greater convenience, especially for those who dislike the taste of licorice or prefer to avoid sweeteners often added to chewables. Powder forms provide maximum flexibility in dosing but require more effort to use consistently.
Dosage varies widely among DGL products, typically ranging from 300mg to 750mg per serving. Clinical research often uses 400mg doses taken 20 minutes before meals, though individual needs may vary. Consider whether you prefer taking one higher-dose serving daily or splitting lower doses throughout the day, and choose a product that aligns with your preference and schedule.
The quality and purity of DGL supplements matter significantly for safety and effectiveness. Look for products that specify their glycyrrhizin content is below 3%, as this is the compound that causes potential side effects in regular licorice. Quality manufacturers will clearly state this on their labels and provide third-party testing results to verify purity and potency.
Additional ingredients can enhance or detract from a DGL supplement’s value. Some products include synergistic ingredients like glycine, calcium, or other soothing herbs such as marshmallow root or slippery elm that may provide complementary digestive support. However, if you’re sensitive to certain ingredients or prefer a pure DGL formula, opt for products with minimal additional components.
Finally, consider the value proposition including cost per serving and total supply. While premium products often provide superior quality and testing, budget-friendly options can also be effective when manufactured to appropriate standards. Calculate the daily cost based on your intended dosage to make accurate comparisons between products.
Benefits of DGL Licorice Supplements
DGL licorice offers numerous benefits for digestive health, stemming from centuries of traditional use combined with modern scientific validation. Understanding these benefits can help you appreciate how DGL might support your wellness goals.
The primary benefit of DGL is its ability to support the health and integrity of the stomach lining. DGL contains flavonoids and other compounds that help maintain the protective mucus layer that shields the stomach from digestive acids. This protective action makes DGL particularly valuable for those experiencing occasional gastric discomfort, as it helps maintain the natural barrier that keeps stomach acid where it belongs while supporting the healing of the digestive tract.
Beyond stomach support, DGL provides soothing benefits throughout the entire gastrointestinal tract. The mucilaginous compounds in DGL help coat and calm inflamed or irritated tissue in the esophagus, stomach, and intestines. This soothing action can help ease occasional digestive upset and support overall comfort in the digestive system, making it useful for various digestive concerns.
DGL also supports healthy inflammatory responses in the digestive system. Unlike regular licorice, DGL maintains these anti-inflammatory benefits without the potential side effects of glycyrrhizin, making it safe for longer-term use. This balanced inflammatory response support contributes to overall digestive wellness and helps maintain the healthy function of the gastrointestinal tract.
Frequently Asked Questions
What is the difference between DGL and regular licorice?
DGL (deglycyrrhizinated licorice) has had the glycyrrhizin compound removed, which is responsible for potential side effects of regular licorice including elevated blood pressure, potassium imbalances, and fluid retention. DGL retains the beneficial compounds that support digestive health while eliminating these concerns, making it safe for long-term use even for people with high blood pressure or those taking certain medications.
Should I choose chewable DGL or capsules?
Chewable DGL tablets are traditionally preferred because chewing allows the supplement to directly coat the esophagus and stomach lining, potentially providing more targeted support. However, capsules offer greater convenience and avoid sweeteners often added to chewables. If you can tolerate chewing tablets 20 minutes before meals, chewables may be more effective, but capsules work well for those prioritizing convenience or avoiding sweeteners.
How long does it take DGL to work?
Many people notice soothing effects from DGL within days of starting supplementation, as it works quickly to coat and protect the digestive tract. However, for supporting the natural healing and maintenance of the stomach lining, most practitioners recommend taking DGL consistently for at least 4-8 weeks. The supplement works best when taken regularly as part of a consistent routine rather than as needed.
Can I take DGL long-term?
Yes, DGL is specifically designed for safe long-term use. Unlike regular licorice which should be limited to short-term use due to glycyrrhizin content, DGL has this compound removed and can be taken for extended periods without the same concerns. Most research and clinical use supports ongoing supplementation for months or even years when needed for digestive support.
What’s the best time to take DGL?
DGL is most effective when taken 20 minutes before meals for chewable forms, as this allows it to coat the digestive tract before food and stomach acid arrive. For capsule forms, timing is less critical, though many people find taking them with or after meals works well. Some practitioners also recommend taking an additional dose at bedtime for overnight support.
Are there any side effects of DGL?
DGL is generally very well-tolerated with minimal side effects when taken at recommended doses. Because the glycyrrhizin has been removed, it doesn’t cause the blood pressure or potassium issues associated with regular licorice. Some people may experience mild digestive changes when first starting DGL, but serious side effects are rare. If you’re pregnant, nursing, or taking medications, consult your healthcare provider before use.
Can I take DGL with other digestive supplements?
Yes, DGL works well with other digestive supplements and is often combined with zinc carnosine, L-glutamine, aloe vera, or slippery elm for comprehensive digestive support. These supplements have complementary mechanisms of action and can be taken together safely. However, if you’re taking medications, especially for acid reflux or stomach issues, consult your healthcare provider to ensure there are no interactions.
How much DGL should I take daily?
Typical dosing ranges from 400mg to 1,600mg daily, depending on individual needs and the specific product. Many people find success with 400mg taken 20 minutes before each meal (1,200mg total daily) for comprehensive support. Start with a lower dose and increase gradually if needed, and always follow the specific product’s dosing recommendations unless otherwise directed by a healthcare professional.
