Best DHT Blocker Supplements (2026) – Top 10 Reviewed
DHT (dihydrotestosterone) is the primary hormone behind androgenetic alopecia—the most common cause of hair loss in both men and women. By inhibiting the 5-alpha reductase enzyme that converts testosterone to DHT, these supplements help protect hair follicles from miniaturization and support healthier hair growth.
The most effective DHT blockers combine proven ingredients like saw palmetto, pumpkin seed oil, and beta-sitosterol with hair-supporting nutrients. Here are our top 10 picks for 2026.
| Product | Key Ingredients | Servings | Form | Best For |
|---|---|---|---|---|
| Extra Strength Saw Palmetto Extract | Saw Palmetto, Plant Sterols, Flavonoids | 200 | Capsules | Best Overall |
| Pumpkin Seed Oil Organic Drops | Pumpkin Seed Oil | 60 | Liquid Drops | Best Natural DHT Blocker |
| Saw Palmetto for Women with Biotin | Saw Palmetto, Biotin 2500mcg | 60 | Gummies | Best for Women |
| Zazzee Saw Palmetto 20:1 Extract | Saw Palmetto 6000mg, 40% Fatty Acids | 120 | Capsules | Best High-Potency |
| Saw Palmetto for Men Prostate Health | Saw Palmetto 500mg | 100 | Capsules | Best Value |
| Lustriva Hair Growth DHT Blocker | Saw Palmetto, Biotin, Zinc, Copper | 30 | Capsules | Best Hair-Focused Formula |
| DHT Blocker for Men Extra Strength | Saw Palmetto, Biotin | 60 | Capsules | Best for Men |
| Totaria Organic Saw Palmetto Prostate | Saw Palmetto, Ashwagandha, Nettle, Pumpkin Seed | 120 | Capsules | Best Multi-Ingredient |
| Stinging Nettle Leaf Extract | Stinging Nettle, USDA Organic | 60 | Liquid Drops | Best Supporting Ingredient |
| Pumpkin Seed Oil with Saw Palmetto | Pumpkin Seed Oil 1000mg, Saw Palmetto | 300 | Softgels | Best Combination Formula |
1. Extra Strength Saw Palmetto Extract – Best Overall
Why it stands out: This advanced herbal complex delivers a clinically-relevant 500mg dose of saw palmetto per serving with added plant sterols and flavonoids to enhance absorption and effectiveness.
Saw palmetto is the most extensively studied natural DHT blocker, with multiple randomized clinical trials demonstrating its ability to inhibit 5-alpha reductase and improve hair quality. A systematic review published in Dermatologic Therapy examined seven studies and found that saw palmetto supplements at doses of 100-320mg showed 60% improvement in overall hair quality, 27% improvement in total hair count, and increased hair density in over 83% of participants.
This formula provides 200 capsules—over a 3-month supply—making it excellent value for the consistent, long-term use that hair supplements require. The addition of plant sterols like beta-sitosterol enhances the DHT-blocking action through competitive inhibition at receptor sites, while flavonoids provide antioxidant support that protects hair follicles from oxidative stress damage. The formula is manufactured in a GMP-certified facility and undergoes third-party testing for purity.
Pros:
- Clinically-studied 500mg saw palmetto dose
- Enhanced with plant sterols and flavonoids for dual-action DHT blocking
- 200-count bottle provides exceptional value for long-term use
- Supports both hair retention and prostate health
Cons:
- Capsules may be large for some users who have difficulty swallowing pills
Best for: Anyone seeking a comprehensive, high-quality saw palmetto supplement backed by research for DHT blocking and willing to commit to consistent daily use.
2. Pumpkin Seed Oil Organic Drops – Best Natural DHT Blocker
Why it stands out: USDA Organic, cold-pressed pumpkin seed oil in a convenient liquid form offers a research-backed alternative to saw palmetto with impressive clinical results for hair growth.
A landmark 2014 randomized, double-blind, placebo-controlled trial published in Evidence-Based Complementary and Alternative Medicine found that men taking 400mg of pumpkin seed oil daily experienced a 40% increase in hair count compared to just 10% in the placebo group over 24 weeks. Participants also reported significantly higher self-rated improvement scores and satisfaction with their hair growth.
The oil’s phytosterols—particularly beta-sitosterol and spinasterol—inhibit the 5-alpha reductase enzyme responsible for converting testosterone to DHT. Unlike some prescription medications, pumpkin seed oil achieves this without reported sexual side effects, making it an attractive option for those concerned about finasteride’s potential drawbacks. This organic liquid formula is cold-pressed to preserve the delicate fatty acids and can be taken directly under the tongue for fastest absorption or added to smoothies, salads, or other foods. The unflavored profile makes it versatile for different uses.
Pros:
- Backed by rigorous clinical research showing 40% hair count improvement
- USDA Organic and cold-pressed for maximum purity and potency
- Versatile liquid form allows flexible dosing and multiple usage options
- Supports hormone balance and hair health in both men and women
Cons:
- Unflavored taste has a distinctive oil profile that may not appeal to everyone
Best for: Those preferring a natural, food-based DHT blocker with strong clinical evidence and wanting to avoid capsule supplements.
3. Saw Palmetto for Women with Biotin – Best for Women
Why it stands out: This gummy formula specifically addresses female hair thinning by combining saw palmetto’s DHT-blocking power with 2500mcg of biotin for comprehensive hair, skin, and nail support.
While DHT-related hair loss is often associated with men, women also experience thinning due to hormonal imbalances—particularly after menopause when estrogen drops and androgens become more dominant. This formula addresses both the hormonal component (saw palmetto) and nutritional support (biotin) in a tasty gummy format. The 60-count bottle provides a full month’s supply.
Pros:
- Formulated specifically for women’s hair health
- Combines DHT blocking with biotin nutrition
- Pleasant-tasting gummy format
- Supports skin and nails alongside hair
Cons:
- One-month supply requires regular reordering
Best for: Women experiencing hormonal hair thinning who prefer a palatable gummy supplement.
4. Zazzee Saw Palmetto 20:1 Extract – Best High-Potency
Why it stands out: This concentrated 20:1 extract delivers the equivalent of 6000mg of saw palmetto per capsule, standardized to 40% fatty acids for maximum DHT-blocking potential.
The fatty acid content of saw palmetto—particularly the 85-90% total fatty acids including lauric, oleic, and myristic acids—is what drives its 5-alpha reductase inhibition. These fatty acids compete with testosterone for enzyme binding sites, effectively reducing DHT production. By standardizing to 40% fatty acids and using a concentrated 20:1 extract ratio, this formula delivers significantly more active compounds per capsule than standard saw palmetto supplements that may contain only raw berry powder.
The 120-capsule bottle provides a 4-month supply at the recommended once-daily dosing, making it cost-effective for those committed to long-term supplementation. Zazzee manufactures in the USA in a GMP-certified facility and uses third-party testing to verify potency and purity. The vegan capsules suit plant-based diets, and the formula is free from common allergens, artificial ingredients, and fillers.
Pros:
- Highest-potency saw palmetto available (6000mg equivalent per capsule)
- Standardized to 40% fatty acids for guaranteed active compound content
- 4-month supply offers excellent long-term value
- Non-GMO, vegan, made in USA with third-party testing
Cons:
- Higher potency may not be necessary for those responding well to standard doses
Best for: Those who haven’t seen adequate results from standard-strength saw palmetto and want maximum DHT inhibition, or anyone seeking the most concentrated formula available.
5. Saw Palmetto for Men Prostate Health – Best Value
Why it stands out: This straightforward 500mg saw palmetto formula delivers proven DHT-blocking benefits in a 100-count bottle lasting over 3 months at an accessible price point.
Sometimes simple is better. This no-frills saw palmetto supplement provides the same 500mg dose used in clinical studies without unnecessary additives or premium pricing. The capsule form is easy to swallow and the vegan, non-GMO formula suits various dietary needs. While marketed for prostate health, the DHT-blocking mechanism works equally well for hair retention—the same pathway benefits both conditions.
Pros:
- Clinically-relevant 500mg dose
- Excellent value with 100+ day supply
- Simple, straightforward formula
- Vegan and non-GMO
Cons:
- Basic formula without complementary ingredients
Best for: Budget-conscious users wanting proven DHT-blocking benefits without paying for extra ingredients.
6. Lustriva Hair Growth DHT Blocker – Best Hair-Focused Formula
Why it stands out: This targeted hair growth supplement combines saw palmetto with biotin, zinc, and copper—minerals specifically shown to support hair follicle health and keratin production.
While DHT blocking addresses the hormonal cause of pattern hair loss, nutritional deficiencies can compound the problem. Zinc is a potent inhibitor of 5-alpha reductase activity—the same enzyme targeted by finasteride—while also being essential for protein synthesis and cell division in hair follicles. Copper supports melanin production and collagen cross-linking. This formula addresses multiple pathways of hair loss in one comprehensive capsule.
Pros:
- Multi-pathway approach to hair loss
- Includes zinc for additional DHT inhibition
- Suitable for both men and women
- Targets shedding reduction and growth support
Cons:
- 30-day supply requires monthly repurchase
Best for: Those experiencing both hormonal and nutritional factors contributing to hair thinning.
7. DHT Blocker for Men Extra Strength – Best for Men
Why it stands out: Specifically formulated for male pattern baldness, this liquid-filled capsule combines saw palmetto and biotin in a proprietary herbal blend for enhanced absorption.
Male androgenetic alopecia typically begins with a receding hairline and thinning at the crown—areas where hair follicles are most sensitive to DHT. This formula uses liquid-filled capsules that may absorb faster than standard powder-filled versions. The extra-strength designation reflects higher concentrations of active ingredients designed for men’s higher average DHT levels.
Pros:
- Formulated specifically for male hair loss patterns
- Liquid-filled capsules for better absorption
- Combines DHT blocking with hair nutrition
- Proprietary herbal blend
Cons:
- Higher price point than basic saw palmetto
Best for: Men in early to moderate stages of pattern hair loss seeking a targeted supplement.
8. Totaria Organic Saw Palmetto Prostate – Best Multi-Ingredient
Why it stands out: This comprehensive formula combines four proven DHT-blocking ingredients—saw palmetto, ashwagandha, stinging nettle, and pumpkin seed—for synergistic hair and hormone support.
Different natural DHT blockers work through slightly different mechanisms: saw palmetto and pumpkin seed inhibit 5-alpha reductase, nettle may block DHT binding to follicle receptors, and ashwagandha helps regulate cortisol levels that can exacerbate hair loss. By combining all four in organic form, this formula addresses DHT from multiple angles while also supporting stress response—a common contributor to hair shedding.
Pros:
- Four complementary DHT-blocking ingredients
- Organic certification for purity
- Ashwagandha adds stress-support benefits
- 120 capsules for 2-month supply
Cons:
- Complex formula may not suit those wanting single-ingredient supplements
Best for: Those wanting comprehensive hormone support from multiple natural DHT blockers.
9. Stinging Nettle Leaf Extract – Best Supporting Ingredient
Why it stands out: This USDA Organic liquid nettle extract provides a powerful complementary DHT blocker often paired with saw palmetto for enhanced effectiveness.
Stinging nettle (Urtica dioica) contains compounds that may block DHT from binding to androgen receptors in hair follicles—a different mechanism than saw palmetto’s enzyme inhibition. Research suggests combining nettle with saw palmetto produces better results than either alone. This organic liquid extract absorbs quickly and can be easily stacked with other DHT blockers. Beyond hair support, nettle provides anti-inflammatory benefits for scalp health.
Pros:
- Complementary mechanism to saw palmetto
- USDA Organic liquid for rapid absorption
- Supports immune and prostate health
- Easy to combine with other supplements
Cons:
- Best used in combination with other DHT blockers rather than alone
Best for: Those already taking saw palmetto who want to enhance their DHT-blocking regimen.
10. Pumpkin Seed Oil with Saw Palmetto – Best Combination Formula
Why it stands out: This softgel combines 1000mg of pumpkin seed oil with saw palmetto in a 300-count bottle, delivering two clinically-proven DHT blockers in one convenient supplement.
Both pumpkin seed oil and saw palmetto have demonstrated DHT-lowering effects in clinical trials, but through slightly different phytosterol profiles. Combining them may provide more comprehensive 5-alpha reductase inhibition than either alone. The softgel format ensures the oils are protected from oxidation and absorb efficiently. At 300 softgels per bottle, this is among the longest-lasting options on our list.
Pros:
- Two proven DHT blockers in one softgel
- Generous 300-count bottle
- Cold-pressed pumpkin seed oil
- Supports hair, prostate, and urinary health
Cons:
- Softgels contain gelatin (not vegan)
Best for: Those wanting maximum DHT-blocking coverage from a single supplement with excellent value.
What is DHT and How Does it Cause Hair Loss?
Dihydrotestosterone (DHT) is an androgen hormone derived from testosterone through conversion by the enzyme 5-alpha reductase. While DHT plays important roles in male development—including facial hair growth, voice deepening during puberty, and muscle development—it can also bind to androgen receptors in hair follicles and trigger a process called follicular miniaturization.
In genetically susceptible individuals, DHT causes hair follicles to progressively shrink, producing thinner, shorter hairs with each growth cycle. The anagen (growth) phase shortens while the telogen (resting) phase lengthens, resulting in hair that spends less time actively growing. Eventually, affected follicles become so miniaturized they can only produce fine, nearly invisible vellus hairs—or stop producing visible hair altogether.
This process primarily affects the hairline and crown in men (male pattern baldness or androgenetic alopecia), following a characteristic pattern that dermatologists classify using the Norwood Scale. In women, DHT-related hair loss typically presents as diffuse thinning across the top of the scalp while the frontal hairline remains relatively preserved—classified using the Ludwig Scale.
Natural DHT blockers work through two primary mechanisms: inhibiting 5-alpha reductase to reduce DHT production, or preventing DHT from binding to follicle receptors. By reducing DHT’s impact on susceptible follicles, these supplements help preserve follicle size and function, allowing hair to grow thicker and longer while slowing or halting the miniaturization process.
How to Choose the Right DHT Blocker Supplement
Key Ingredients to Look For
The most effective natural DHT blockers include saw palmetto extract (Serenoa repens), pumpkin seed oil (Cucurbita pepo), stinging nettle root (Urtica dioica), pygeum bark (Prunus africana), and beta-sitosterol. Each works primarily by inhibiting 5-alpha reductase, though through slightly different phytochemical pathways.
For saw palmetto, look for extracts standardized to fatty acid content—typically 85-95% total fatty acids including lauric, oleic, and myristic acids. Clinical studies typically use doses of 200-320mg daily of standardized extract. A 2020 systematic review found that 320mg daily of saw palmetto reduced hair fall by up to 29% and increased hair density by 5-7% over 16 weeks.
Pumpkin seed oil shows benefits at 400mg daily based on the landmark Korean clinical trial. The key active compounds are phytosterols, particularly beta-sitosterol, which directly compete with DHT for receptor binding sites. Cold-pressed, organic oils retain more of these beneficial compounds than heat-processed versions.
Supporting nutrients like zinc (which also inhibits 5-alpha reductase), biotin (for keratin production), and iron (essential for hair follicle function) can complement DHT blockers for more comprehensive hair support.
Forms Compared
Capsules and softgels are the most common delivery methods for DHT blockers. Standard capsules work well for dried herbal extracts like saw palmetto powder, while softgels are superior for oil-based ingredients like pumpkin seed oil and saw palmetto oil extracts—protecting delicate fatty acids from oxidation and improving bioavailability.
Liquid extracts absorb fastest since they bypass the need for capsule dissolution in the stomach. They also allow flexible dosing, making it easy to adjust your intake. However, oils and tinctures may have strong flavors that some find unpleasant.
Gummies appeal to those who dislike swallowing pills but typically contain added sugars and may have lower concentrations of active ingredients due to formulation constraints. They’re a reasonable option for those who wouldn’t otherwise take supplements consistently.
What to Avoid
Be wary of products making dramatic “regrowth” claims or promising results within weeks—natural DHT blockers work gradually and are most effective for slowing loss and maintaining existing hair rather than reversing advanced baldness. If scalp is clearly visible through your hair, supplements alone likely won’t restore full coverage.
Avoid supplements with proprietary blends that don’t disclose individual ingredient amounts, as you can’t verify you’re getting clinically-effective doses. A “proprietary blend” of 500mg could contain 490mg of filler and only 10mg of the active ingredient.
Skip products with unnecessary fillers, artificial colors, titanium dioxide, or ingredients you can’t identify. Quality manufacturers use minimal excipients and clearly label all contents. If a supplement seems dramatically cheaper than competitors, the extract quality, potency, or purity may be compromised.
Side Effects and Precautions
Natural DHT blockers like saw palmetto and pumpkin seed oil are generally well-tolerated with a favorable safety profile compared to prescription alternatives. The most common side effects include mild gastrointestinal discomfort such as stomach upset, nausea, or digestive irregularity. These symptoms can typically be minimized by taking supplements with food, particularly a meal containing some fat to aid absorption of oil-based ingredients.
Some users report headaches during initial use, which often resolve within the first week or two as the body adjusts. Dizziness has been reported rarely. In clinical trials of saw palmetto for hair loss, adverse effects were not significantly different from placebo groups, suggesting good tolerability.
Because these supplements influence hormone metabolism—specifically by reducing DHT production—certain precautions apply. Pregnant and breastfeeding women should avoid DHT blockers entirely, as alterations to androgen levels could theoretically affect fetal development. Women who may become pregnant should also exercise caution.
Men using saw palmetto should inform their healthcare provider before prostate cancer screening, as saw palmetto may lower PSA (prostate-specific antigen) levels by up to 50% after 6-12 months of use. This could mask elevated PSA that would otherwise prompt further investigation. Your doctor can account for this effect when interpreting results.
Those taking blood thinners (like warfarin), hormone medications, or birth control pills should consult a healthcare provider before starting DHT blockers due to potential interactions. While natural DHT blockers are generally considered safer than finasteride regarding sexual side effects, some researchers note that any substance lowering DHT through similar pathways could theoretically produce comparable effects in sensitive individuals. If you experience breast tenderness, significant libido changes, or erectile difficulties, discontinue use and consult a doctor.
FAQs
How long does it take for DHT blockers to work for hair loss?
Most clinical studies show initial improvements in hair shedding within 8-12 weeks, with more noticeable changes in density and thickness appearing after 16-24 weeks of consistent daily use. Natural DHT blockers work gradually by protecting follicles from further miniaturization—patience and consistency are essential.
Can women take DHT blocker supplements?
Yes, women can benefit from natural DHT blockers, particularly after menopause when declining estrogen allows androgens to have greater impact on hair follicles. Saw palmetto and pumpkin seed oil have been studied in women with positive results. However, women who are pregnant, breastfeeding, or trying to conceive should avoid these supplements.
Are natural DHT blockers as effective as finasteride?
Natural DHT blockers are less potent than prescription finasteride. Studies show saw palmetto reduces DHT by approximately 10-30%, compared to finasteride’s 60-70% reduction. However, natural options come with fewer side effects and no prescription requirements, making them appropriate for early-stage thinning or as complementary treatments.
Can I take multiple DHT blockers together?
Yes, combining different natural DHT blockers may provide enhanced benefits since they work through slightly different mechanisms. Common stacks include saw palmetto plus pumpkin seed oil, or saw palmetto plus stinging nettle. Start with one supplement to assess tolerance before adding others.
Do DHT blockers have sexual side effects like finasteride?
While natural DHT blockers are generally considered safer than finasteride regarding sexual side effects, some researchers note that any substance lowering DHT through the same pathway could theoretically produce similar effects in sensitive individuals. Most users report no sexual side effects, but discontinue use and consult a doctor if you experience decreased libido or erectile changes.
Should I take DHT blockers with food?
Taking DHT blocker supplements with food—particularly meals containing some fat—can improve absorption of fat-soluble compounds like saw palmetto fatty acids and pumpkin seed oil. Food also reduces the likelihood of stomach upset. Most studies used supplements taken with meals.
Final Verdict
For comprehensive DHT blocking with strong clinical backing, the Extra Strength Saw Palmetto Extract stands out as our top pick—delivering proven ingredients at an effective dose with plant sterols for enhanced action and excellent long-term value. The 200-capsule count means you won’t be constantly reordering, and the research supporting saw palmetto is more extensive than any other natural DHT blocker.
Those preferring an alternative to saw palmetto or seeking variety in their approach should consider Pumpkin Seed Oil Organic Drops, which demonstrated impressive 40% hair count improvements in a rigorous randomized controlled trial. The liquid format offers flexibility and rapid absorption.
Women experiencing hormonal hair thinning—particularly around menopause—will appreciate the Saw Palmetto for Women with Biotin gummies that combine DHT blocking with beauty-supporting nutrients in an enjoyable daily format. For maximum potency when standard doses haven’t delivered results, the Zazzee Saw Palmetto 20:1 Extract offers the highest concentration available at a standardized fatty acid content.
Budget-conscious users can achieve solid results with the straightforward Saw Palmetto for Men Prostate Health formula—proof that effective DHT blocking doesn’t require premium pricing. And for those wanting to cover all bases, the Pumpkin Seed Oil with Saw Palmetto combination softgels deliver two proven DHT blockers in one convenient supplement.
Remember that natural DHT blockers work best for early-stage thinning and as part of a comprehensive hair care routine that may include proper nutrition, scalp care, and stress management. These supplements won’t regrow hair in areas that have been bald for years, but they can help maintain what you have and potentially improve thickness and quality over time. Consistency over several months—typically 4-6 months minimum—is essential for seeing meaningful results.
