Best Dog Digestive Enzyme Supplements (2026) – Top 10 Reviewed
Does your dog deal with gas, bloating, loose stools, or an upset stomach? Digestive enzyme supplements help dogs break down food more efficiently, supporting nutrient absorption and overall gut health. They’re especially helpful for dogs with sensitive stomachs, those transitioning to new foods, or senior dogs whose enzyme production has slowed.
The best digestive enzyme supplements combine enzymes like protease, lipase, and amylase with probiotics and prebiotics for complete gut support. Quality ingredients, palatability, and proven effectiveness separate the top products from the rest. Here are our top 10 picks for 2026.
| Product | Key Ingredients | Count | Form | Best For |
|---|---|---|---|---|
| STRELLALAB Probiotics + Enzymes | Probiotics, Enzymes, Fiber | 180 | Chews | Best Overall |
| VetriScience Extra Strength Gut Health | Probiotics, Prebiotics | 180 | Capsules | Best Vet-Formulated |
| Perfect Poop Digestion Supplement | Fiber, Prebiotics, Probiotics, Enzymes | 4.2 oz | Powder | Best for Stool Quality |
| Poop Fixer Carrot & Pumpkin Powder | Pumpkin, Carrot, Fiber | 13.4 oz | Powder | Best Natural Formula |
| VetriScience Gut Health Chews | Probiotics, 1B CFU | 120 | Chews | Best Daily Maintenance |
| Vet Promise Super Poop Probiotics | 6 Probiotics, Enzymes, Fiber | 120 | Chews | Best Value |
| Probiotics for Dogs & Digestive Enzymes | Probiotics, Prebiotics, Enzymes | 170 | Chews | Best High-Count |
| STRELLALAB Anal Gland Support | Enzymes, Prebiotics, Fiber, Pumpkin | 120 | Chews | Best for Anal Gland Issues |
| Natural Dog Company Gut Health | Canine-Specific Probiotics, Enzymes | 60 | Chews | Best for Sensitive Dogs |
| VetriScience Acetylator | Digestive Enzymes, Probiotics | 120 | Capsules | Best for Bowel Discomfort |
1. STRELLALAB Dog Probiotics Chews + Enzymes – Best Overall
Why it stands out: This comprehensive formula combines probiotics with digestive enzymes in a tasty chicken-flavored chew that dogs actually enjoy eating. It addresses gas, diarrhea, and upset stomach while supporting immune function.
STRELLALAB packs probiotics, digestive enzymes, and fiber into each chew to tackle multiple digestive issues at once. The chicken flavor makes daily dosing easy, even for picky eaters. At 180 chews per container, you’re getting solid value for a multi-month supply for most dogs. This is a great all-around choice for dogs dealing with occasional digestive upset or those needing ongoing gut support.
Pros:
- Complete formula with probiotics, enzymes, and fiber
- Tasty chicken flavor dogs love
- 180-count container offers great value
- Addresses gas, diarrhea, and immune support
Cons:
- Large dogs may go through supply faster
Best for: Dog owners wanting one supplement to address multiple digestive concerns.
2. VetriScience Extra Strength Gut Health – Best Vet-Formulated
Why it stands out: VetriScience is a trusted name in veterinary supplements, and this extra-strength formula delivers 7.5 billion CFU per capsule with both probiotics and prebiotics for maximum gut support.
These easy-open capsules work for both dogs and cats, making them ideal for multi-pet households. The high CFU count targets diarrhea, gas, and immune support at therapeutic levels. The capsule format allows you to open and sprinkle on food if your dog won’t take pills. VetriScience’s veterinarian-developed formulas have a strong reputation for quality and efficacy.
Pros:
- Extra-strength 7.5 billion CFU per capsule
- Works for dogs and cats
- Easy-open capsules for flexible dosing
- Veterinarian-formulated
Cons:
- Capsule form may require opening for picky dogs
Best for: Pet parents seeking a vet-recommended, high-potency probiotic for serious digestive issues.
3. Perfect Poop Digestion Supplement – Best for Stool Quality
Why it stands out: This unique grass bits formula combines fiber, prebiotics, probiotics, and enzymes specifically designed to optimize stool quality—firming up loose stools or softening hard ones.
Perfect Poop takes a 4-in-1 approach with fiber for bulk, prebiotics to feed good bacteria, probiotics for gut balance, and enzymes for better digestion. The cheddar cheese flavor is surprisingly popular with dogs. It’s especially effective for dogs with inconsistent stool quality or those recovering from digestive upset. The powder format mixes easily into wet or dry food.
Pros:
- 4-in-1 formula targets complete digestive health
- Specifically optimizes stool consistency
- Tasty cheddar cheese flavor
- Powder mixes easily with food
Cons:
- Powder may not work for dogs who avoid food toppers
Best for: Dogs with loose stools, constipation, or inconsistent poop quality.
4. Poop Fixer Carrot & Pumpkin Powder – Best Natural Formula
Why it stands out: This whole-food approach uses pumpkin and carrot as the primary ingredients, providing natural fiber and digestive support without synthetic additives.
Pumpkin is a veterinarian-favorite for digestive issues, and this formula delivers it in concentrated powder form alongside carrots for added fiber and nutrients. It works for both dogs and cats, addressing diarrhea, constipation, and anal gland support naturally. The 13.4 oz container provides excellent value, and the gentle formula is safe for long-term daily use. Great for pet parents who prefer food-based solutions over synthetic supplements.
Pros:
- Whole-food ingredients dogs recognize
- Works for both diarrhea and constipation
- Large 13.4 oz container
- Safe for dogs and cats
Cons:
- May take longer to show results than enzyme-heavy formulas
Best for: Pet parents preferring natural, food-based digestive support.
5. VetriScience Gut Health Chews – Best Daily Maintenance
Why it stands out: These everyday probiotic chews deliver 1 billion CFU per chew in a duck-flavored soft chew format, perfect for maintaining gut health rather than treating acute issues.
VetriScience designed these chews for daily digestive maintenance, supporting healthy digestion, reducing occasional gas and diarrhea, and boosting immune function. The duck flavor is a nice alternative for dogs with chicken sensitivities. At 120 chews, most dogs get a 2-4 month supply. The moderate probiotic strength makes it appropriate for everyday use without overwhelming the gut.
Pros:
- Perfect for daily maintenance
- Duck flavor for chicken-sensitive dogs
- 1 billion CFU per chew
- Trusted VetriScience quality
Cons:
- May not be strong enough for acute digestive issues
Best for: Dogs needing ongoing digestive support rather than acute treatment.
6. Vet Promise Super Poop Probiotics – Best Value
Why it stands out: This budget-friendly option doesn’t skimp on quality, delivering 6 different probiotic strains plus digestive enzymes and fiber at an accessible price point.
Vet Promise combines probiotics, digestive enzymes, and fiber to address both soft and hard stool issues. It works as a stool softener for constipated dogs while also firming up loose stools—the fiber and probiotics work together to normalize whatever direction your dog needs. The 120-chew count at a lower price point makes this an excellent entry option for pet parents new to digestive supplements.
Pros:
- 6 probiotic strains for diverse gut support
- Addresses both soft and hard stool
- Budget-friendly pricing
- Includes enzymes and fiber
Cons:
- Less established brand than VetriScience
Best for: Budget-conscious pet parents wanting comprehensive digestive support.
7. Probiotics for Dogs & Digestive Enzymes (170 Chews) – Best High-Count
Why it stands out: At 170 chews per container, this bacon-flavored option provides one of the highest counts available, maximizing value for multi-dog households or larger breeds.
This formula combines probiotics with prebiotics and digestive enzymes to tackle gas, diarrhea, upset stomach, and constipation. The bacon flavor is a hit with most dogs, making daily supplementation easy. The high chew count means you won’t run out quickly, even with larger dogs or multiple pets. It’s a solid all-around digestive supplement at a competitive price per chew.
Pros:
- 170 chews per container
- Bacon flavor dogs love
- Complete probiotic, prebiotic, and enzyme formula
- Good value per chew
Cons:
- Bacon flavor may not appeal to all dogs
Best for: Large breed owners or multi-dog households needing bulk supply.
8. STRELLALAB Anal Gland Support Chews – Best for Anal Gland Issues
Why it stands out: While primarily targeting anal gland health, this formula’s digestive enzymes, prebiotics, and fiber make it excellent for overall digestive support—especially for dogs who scoot.
STRELLALAB combines beet, psyllium, dandelion, and pumpkin with digestive enzymes and prebiotics. This fiber-rich blend supports healthy, firm stools that help express anal glands naturally during bowel movements. If your dog scoots, has recurring anal gland issues, or struggles with soft stools, this addresses the root digestive causes rather than just symptoms.
Pros:
- Targets anal gland issues at the source
- Rich fiber blend with pumpkin and psyllium
- Digestive enzymes for better nutrient breakdown
- 120 chews per container
Cons:
- May be overkill if anal glands aren’t a concern
Best for: Dogs with anal gland problems, scooting, or chronically soft stools.
9. Natural Dog Company Gut Health Chews – Best for Sensitive Dogs
Why it stands out: This formula uses canine-specific probiotic strains matched to dogs’ unique gut microbiome, plus prebiotics and digestive enzymes in a gentle once-daily chew.
Natural Dog Company formulated these specifically for dogs rather than using generic probiotics. The canine-specific strains may colonize more effectively in your dog’s gut. It addresses digestion, gas, loose stool, immune support, and bowel health with just one daily chew. The 60-count is a 2-month supply, and the gentle formula works well for dogs with sensitive systems who react poorly to stronger supplements.
Pros:
- Canine-specific probiotic strains
- Gentle formula for sensitive dogs
- Once-daily dosing
- Addresses multiple digestive concerns
Cons:
- Smaller count than some competitors
Best for: Dogs with sensitive stomachs who need a gentler approach.
10. VetriScience Acetylator Digestive Enzymes – Best for Bowel Discomfort
Why it stands out: This specialized formula focuses on digestive enzymes combined with probiotics to soothe gut and bowel discomfort, making it ideal for dogs with chronic digestive sensitivity.
VetriScience’s Acetylator takes a targeted approach with digestive enzymes and probiotics designed specifically to calm gut irritation and bowel discomfort. The easy-open capsules work for both dogs and cats. This is a more therapeutic-focused option for dogs with ongoing digestive issues rather than occasional upset. The veterinary-strength formula addresses chronic problems that everyday probiotics may not resolve.
Pros:
- Focuses on soothing bowel discomfort
- Veterinary-strength formula
- Works for dogs and cats
- 120 capsules per bottle
Cons:
- Capsule form requires opening for some dogs
- Higher price point
Best for: Dogs with chronic digestive sensitivity or bowel discomfort.
How to Choose the Right Digestive Enzyme Supplement for Your Dog
Key Ingredients to Look For
The best digestive enzyme supplements include protease (breaks down proteins), lipase (breaks down fats), and amylase (breaks down carbohydrates). Look for formulas that also include probiotics like Lactobacillus and Bifidobacterium strains, which populate the gut with beneficial bacteria. Prebiotics such as inulin and FOS feed these good bacteria. Fiber from pumpkin, beet pulp, or psyllium helps normalize stool consistency.
Size & Breed Considerations
Most digestive supplements dose by weight, typically offering guidelines for small (under 25 lbs), medium (25-50 lbs), and large (over 50 lbs) dogs. Large and giant breeds may need higher doses or go through supplements faster, so consider higher-count containers. Small dogs often do well with half-doses of standard chews or powder supplements where you can control the amount precisely.
Form Factor: Chews vs Powder vs Capsules
Soft chews are the most popular format because dogs treat them like treats, making daily dosing easy. Powders offer flexible dosing and mix well into wet food but may be rejected by dogs who notice food changes. Capsules can be opened and sprinkled on food or given whole to dogs who take pills easily. Choose based on your dog’s preferences—the best supplement is one your dog will actually take.
What to Avoid
Skip supplements with artificial colors, flavors, or preservatives that may irritate sensitive digestive systems. Avoid products that don’t list specific probiotic strains and CFU counts—vague “probiotic blend” labels often mean low potency. Be wary of supplements making medical claims about treating diseases, as digestive supplements support gut health but don’t cure conditions.
Signs Your Dog May Need Digestive Enzymes
- Chronic gas or bloating: Excessive flatulence often indicates incomplete food breakdown
- Loose stools or diarrhea: May signal poor nutrient absorption or gut imbalance
- Constipation or straining: Fiber and enzymes can help normalize bowel movements
- Eating grass frequently: Dogs sometimes eat grass to soothe digestive discomfort
- Vomiting undigested food: Could indicate insufficient enzyme production
- Poor coat quality despite good diet: Nutrient malabsorption affects skin and coat
- Low energy or weight loss: Poor digestion means fewer nutrients reach your dog’s body
If your dog shows severe or persistent symptoms, consult your veterinarian to rule out underlying conditions before starting supplements.
Side Effects and Safety
Most dogs tolerate digestive enzyme supplements well, but some may experience temporary gas, bloating, or loose stools when first starting—especially with probiotic-heavy formulas. Introduce new supplements gradually, starting with half the recommended dose for the first week. This allows your dog’s gut microbiome to adjust without overwhelming it.
Digestive supplements are generally safe for long-term use, but check with your vet if your dog takes medications, as enzymes can affect absorption of certain drugs. Pregnant or nursing dogs should only take supplements approved by a veterinarian. If symptoms worsen or don’t improve after 2-4 weeks of supplementation, seek veterinary guidance.
FAQs
How much digestive enzyme supplement should I give my dog?
Follow the product’s weight-based dosing guidelines, typically one chew for dogs under 25 lbs, two for 25-50 lbs, and three for dogs over 50 lbs. When starting, begin with half the recommended dose and increase gradually over 1-2 weeks.
How long until I see results from digestive enzymes?
Most dogs show improvement in stool quality and reduced gas within 1-2 weeks. Full benefits for gut health and immune support may take 4-6 weeks of consistent daily use. If you see no improvement after a month, consult your vet.
Can I give my puppy digestive enzyme supplements?
Most digestive supplements are safe for puppies over 12 weeks old, though some products specify adult dogs only. Check the label and consider a puppy-specific formula. Puppies’ digestive systems are still developing, so use gentle formulas at reduced doses.
Are there any side effects from digestive enzymes?
Some dogs experience temporary increased gas or loose stools when first starting, especially with probiotic-heavy supplements. This usually resolves within a week as the gut adjusts. Severe reactions are rare but discontinue use if you notice vomiting, hives, or significant digestive upset.
Can I give digestive enzymes with other supplements or medications?
Generally yes, but space them apart by at least an hour since enzymes may affect absorption of certain medications. Always check with your vet if your dog takes prescription medications, especially antibiotics, which can interact with probiotics.
Should I give digestive enzymes with food or on an empty stomach?
Give digestive enzyme supplements with meals for best results. The enzymes work alongside your dog’s natural digestive processes to break down the food they’re eating. Probiotics can be given with or without food, but most combination supplements work best at mealtime.
Final Verdict
For most dogs, STRELLALAB Probiotics + Enzymes offers the best combination of complete gut support, palatability, and value. If you prefer a vet-formulated option with higher potency, VetriScience Extra Strength Gut Health delivers 7.5 billion CFU per capsule from a trusted veterinary brand.
Budget-conscious pet parents should consider Vet Promise Super Poop Probiotics, which delivers six probiotic strains plus enzymes at an accessible price. For dogs with chronic soft stools or anal gland issues, STRELLALAB Anal Gland Support addresses the digestive root causes. And if your dog has a sensitive stomach, Natural Dog Company Gut Health uses canine-specific strains for gentler support.
