Best EPA DHA Supplements (2026) – Top 10 Reviewed
EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid) are the two most important omega-3 fatty acids for human health, supporting everything from cardiovascular function to brain health and eye wellness. If you’re looking to optimize your omega-3 intake with supplements specifically high in these crucial compounds, you’ll want products that deliver meaningful amounts of EPA and DHA in their most absorbable forms. This guide reviews the top EPA DHA supplements available, helping you choose the right formula for your wellness goals.
Our Top Picks at a Glance
- Best Overall: Designs for Health OmegAvail Hi-Po — 1600mg EPA/DHA in triglyceride form
- Best Value: Luma Nutrition Omega-3 — impressive 2000mg EPA & DHA per serving
- Best Premium: Triple Strength Omega-3 — re-esterified TG form for maximum absorption
Quick Comparison
| Product | Key Ingredients | Form | Servings | Best For |
|---|---|---|---|---|
| Designs for Health OmegAvail Hi-Po | 1600mg EPA/DHA (TG form) | Softgels | 60 | Overall use |
| Luma Nutrition Omega-3 2500mg | 2000mg EPA & DHA | Softgels | 120 | Best value |
| Triple Strength Omega-3 2500mg | 2500mg re-esterified TG | Softgels | 180 | Premium absorption |
| Metagenics OmegaGenics EPA 1200 | 1200mg EPA per serving | Softgels | 120 | High EPA concentration |
| NATURE TARGET Omega-3 1600mg | EPA/DHA with PS & CoQ10 | Softgels | 120 | Multi-nutrient support |
| Natural Force Pure Omega-3 | Liquid EPA/DHA, lemon flavor | Liquid | 48 | Liquid preference |
| 1MD Nutrition KrillMD | Krill oil EPA/DHA with astaxanthin | Softgels | 60 | Krill oil alternative |
| ZEBORA CoQ10 with Omega-3 | Omega-3 plus 400mg CoQ10 | Softgels | 120 | Heart health combo |
1. Designs for Health OmegAvail Hi-Po — Best Overall
- High Concentration, Multi-Form Fish Oils - BioGlycerides uniquely combines three different forms of fish oils for improved bioavailability and distribution to tissues. Contains 1600mg of EPA/DHA combined per serving in a 1:1 ratio.
- Sustainable Sourcing - Sourced from sustainable wild-caught anchovy, sardine, and mackerel fish from Peru and Chile.
- Digestibility Support & Minimizing Fishy Aftertaste - The addition of lipase makes it easier for your body to digest and absorb the fish oils and to help avoid a fishy aftertaste.
- Purity Assurance - The fish oil undergoes molecular distillation and filtration, ensuring it’s pure and free from pesticides, PCBs, and other contaminants.
- Clinically-Trusted Care - DFH is the #1 practitioner supplement brand recommended by functional medicine professionals and the #1 practitioner supplement brand personally trusted by functional medicine professionals.**
This professional-grade supplement delivers a concentrated 1,600mg of EPA and DHA in the superior triglyceride form for maximum absorption and effectiveness.
OmegAvail Hi-Po uses TruTG™ omega-3s, which maintain the natural triglyceride structure found in fish for optimal bioavailability. The formula undergoes molecular distillation to achieve pharmaceutical-grade purity, removing mercury, PCBs, and other contaminants. Each serving provides balanced EPA and DHA ratios to support cardiovascular health, brain function, and anti-inflammatory responses throughout the body.
What We Like
- Superior triglyceride form for enhanced absorption
- Pharmaceutical-grade purity with rigorous testing
- Professional quality trusted by healthcare practitioners
What Could Be Better
- Premium pricing reflects professional-grade quality
- Larger softgel size due to concentrated formula
Bottom Line: The gold standard for those seeking maximum EPA and DHA absorption in a professionally formulated supplement.
2. Luma Nutrition Omega-3 2500mg — Best Value
- Best Omega 3 Supplement: Luma Nutrition's fish oil omega 3 supplements are premium quality with an extra strength dosage. Omega 3 fish oil with 2000mg of high quality EPA & DHA Omega 3 fatty acids, all in a softgel capsule to enhance absorption for maximum benefits.
- High EPA Fish Oil: Our product is a high epa omega 3 fish oil supplement, containing 2500 mg of fish oil, far exceeding competitor's fish oil 1200 mg servings. This omega 3 fatty acid supplement is perfect for heart circulation and brain health, supports a healthy immune system, and contributes to radiant skin and hair.
- Myriad of Health Benefits: Omega-3 fatty acids are vital to maintain healthy cardiovascular and eye function. Omega 3 fish oil supports cognitive function, improving memory, focus, and overall brain health. In addition, its overall calming properties on the body can alleviate joint stiffness, enhancing long term mobility and flexibility in aging adults.
- 30 Day Supply: Each bottle of Luma Nutrition's burpless fish oil pills last for a month to maintain optimal freshness and provide strong daily support straight from nature. This all natural cardiovascular and joint support supplement makes the perfect monthly subscription for men and women. Stay in stock and save money at the same time!
- Made in the USA by Veteran-Owned Small Business: Trust in Luma Nutrition's GMP certified, USA-manufactured supplements that are 3rd party verified. As a veteran-owned brand, we prioritize quality and expert craftsmanship to assist with your health journey.
This extra-strength formula delivers an exceptional 2,000mg of combined EPA and DHA per serving at an excellent price point.
Luma Nutrition provides 2,500mg of total fish oil concentration, with 2,000mg coming from EPA and DHA omega-3s. The fish oil is molecularly distilled and third-party tested to ensure purity and freedom from contaminants. Each 120-softgel bottle provides a 60-day supply, making it one of the most cost-effective high-potency options available without sacrificing quality.
What We Like
- Exceptional EPA and DHA concentration
- Outstanding value for the potency provided
- Third-party tested for purity
What Could Be Better
- Some users report mild fishy aftertaste
- Larger softgels required for high concentration
Bottom Line: An excellent choice for those seeking maximum EPA and DHA without paying premium prices.
3. Triple Strength Omega-3 2500mg — Best Premium
- Triple strength omega-3 fish oil - Our fish oil for men and women delivers a high-potency dose of omega-3 with each serving providing 2,500 mg of fish oil, including 1,500 mg EPA, 570 mg DHA and 50 mg DPA
- Omega-3 for heart, brain, skin & eye health* - Science has shown that not only do the omega-3s in fish oil offer cardiovascular support for men and women, but they also support brain health, skin and eye health*
- Purified to reduce mercury - Using a combination of fish (sardines, anchovies and mackerel), our fish oil is purified to reduce PCBs, dioxins, furans and mercury to ensure levels are below IFOS set limits of ≤45 ppb, ≤ 1 ppt and ≤ 0.1 ppm respectively
- For greater absorption - The omega-3 fatty acids in our fish oil capsules are delivered in re-esterified triglyceride form. Triglycerides have been shown to be more easily absorbed by your body
- Quality you can trust - Made with wild caught fish using sustainable fishing practices. Our fish oil softgels are IFOS Certified and Labdoor Certified for quality, purity and potency, and are also gluten-free, non-GMO and pescatarian-friendly
This maximum-strength formula utilizes the re-esterified triglyceride form for superior bioavailability and includes beneficial DPA alongside EPA and DHA.
The re-esterified triglyceride form offers significantly better absorption than standard ethyl ester fish oils, ensuring your body can effectively utilize the omega-3s. Each serving provides 2,500mg of concentrated omega-3s including EPA, DHA, and the lesser-known but beneficial DPA (docosapentaenoic acid). The pescatarian-friendly formula is molecularly distilled for purity.
What We Like
- Re-esterified TG form for maximum absorption
- Includes beneficial DPA not found in all fish oils
- Large 180-count bottle for extended use
What Could Be Better
- Premium form commands higher price
- Requires taking multiple softgels per serving
Bottom Line: Perfect for those prioritizing absorption and willing to invest in the most bioavailable EPA DHA form.
4. Metagenics OmegaGenics EPA 1200 — Best High EPA
- Provides 1200 mg of EPA per serving in a high-potency, pharmaceutical-grade fish oil to support cardiovascular function, healthy triglyceride levels, and immune system health*
- Made from sustainably sourced, wild-caught cold-water fish with a burpless, enteric-coated formula for optimal absorption and no fishy aftertaste*
- Third-party tested for over 200 contaminants to ensure exceptional purity, potency, and freshness—backed by rigorous quality standards and clinical research*
- Produced in a cGMP-certified facility and Certified B Corporation; trusted by healthcare practitioners for over 40 years for safety, transparency, and results*
This EPA-concentrated formula delivers 1,200mg of EPA per serving, ideal for those specifically seeking high EPA for cardiovascular support.
Metagenics emphasizes EPA concentration, which research particularly associates with heart health benefits including triglyceride support and cardiovascular function. The pharmaceutical-grade fish oil undergoes multiple purification steps and uses enteric coating to reduce fishy aftertaste while ensuring the omega-3s reach your intestines for optimal absorption. This professional-quality supplement is sustainably sourced and rigorously tested.
What We Like
- Very high EPA concentration for targeted benefits
- Pharmaceutical-grade quality and purity
- Enteric coating minimizes fishy burps
What Could Be Better
- Lower DHA content than balanced formulas
- Professional-grade pricing
Bottom Line: An excellent choice for those specifically seeking high EPA content for cardiovascular wellness.
5. NATURE TARGET Omega-3 1600mg — Best Multi-Nutrient
- Targeted Cognitive Support : Enriched with the key brain nutrient Phosphatidylserine (PS) that works synergistically with DHA to maintain cell membrane fluidity and neurotransmitter release, enhancing memory and concentration. Ideal for those under work stress and older adults.
- Fuel Your Brain, Power Your Day : Coenzyme Q10 supports mitochondrial ATP production, converting nutrients into energy. Helps reduce mental fatigue, boost clarity, and improve productivity—perfect for professionals and frequent mental workers to stay energized all day.
- Higher Purity, Better Absorption : Sourced from small deep-sea fish, rich in DHA and EPA for high absorption. Essential for supporting brain function and cognitive health. Regular supplementation helps improve memory, focus, and overall mental clarity.
- No Fishy Aftertaste Or Burps : Employing advanced purification techniques to remove mercury and heavy metals, and encapsulating the fish oil in a special enteric coating, this formula ensures purity and safety. It prevents the fish oil from breaking down in the stomach, thereby avoiding fishy aftertaste or burping and reducing gastric discomfort.
- Commitment To Quality : We are committed to quality safety and production compliance. All products have undergone third-party testing and are produced in accordance with cGMP standards. NATURE TARGET Fish Oil Omega 3 is a non-genetically modified product, free of gluten, soy, and artificial additives, ensuring its purity and safety.
This comprehensive formula combines 1,600mg of EPA and DHA with phosphatidylserine and CoQ10 for synergistic wellness benefits.
NATURE TARGET enhances their high-purity omega-3 fish oil with phosphatidylserine for cognitive support and CoQ10 for cellular energy and heart health. The combined formula addresses multiple aspects of wellness in one convenient supplement. The fish oil base provides substantial EPA and DHA while the complementary nutrients work synergistically to support cardiovascular and brain function.
What We Like
- Combines EPA/DHA with brain-supporting nutrients
- High-purity fish oil base
- Addresses multiple wellness goals
What Could Be Better
- Higher price for multi-ingredient formula
- May duplicate other supplements you’re taking
Bottom Line: A smart option for those wanting EPA and DHA plus additional heart and brain-supporting nutrients.
6. Natural Force Pure Omega-3 — Best Liquid
- Concentrated Liquid Lemon Fish Oil - Get the benefits of omega 3s without the discomfort of hard to swallow capsules. Just one teaspoon of Pure Omega-3 provides 1,326mg of pure, concentrated EPA, DHA, and DPA omega 3s in a highly bioavailable natural triglyceride form
- Marine Stewardship Council Certified & Keto, Paleo, Kosher, and Halal – Natural Force Pure Omega-3 is sourced from a Marine Stewardship Council certified sustainable fishery. And, with all natural ingredients like rosemary extract, monk fruit, and zero sugar, it is also certified Keto, Paleo Friendly, Kosher, and Halal
- Mercury Free and Lab Tested for Purity, Potency, and Quality - Ultra purified, molecularly filtered, and sustainably sourced from wild caught menhaden fish, Pure Omega-3 is lab tested to ensure every batch is free of mercury, dioxins, PCBs, and gluten. We freely share the results of our testing because we have nothing to hide!
- Delicious Lemon Cake Flavor - Pure Omega-3 has a delicious lemon cake flavor that makes it perfect for smoothies, shakes, or straight off the spoon. Plus, it comes packaged in a UV light blocking amber glass bottle that preserves freshness and flavor
- Nutrition You Can Trust - Natural Force values the health and happiness of our customers. If you have any questions, comments, or concerns, send us a message from your Amazon account and our world-class Customer Support team will help to make it right
This pleasant-tasting liquid fish oil provides concentrated EPA and DHA with a delicious lemon cake flavor that masks any fish taste.
Natural Force sources wild-caught fish from pristine waters and uses molecular distillation to remove mercury and contaminants. The lemon cake flavoring makes this liquid easy to take directly or add to smoothies and beverages. Liquid form offers flexible dosing and may be easier to swallow than large softgels, particularly for those who have difficulty with pills.
What We Like
- Delicious flavor makes daily use enjoyable
- Liquid form easier than swallowing capsules
- Wild-caught, mercury-free fish source
What Could Be Better
- Requires refrigeration after opening
- Less portable than capsules for travel
Bottom Line: Perfect for those who prefer liquid supplements or want flexible dosing of their EPA and DHA.
7. 1MD Nutrition KrillMD — Best Krill Oil
- 2x More Effective Than Fish Oil: KrillMD is made from sustainably-sourced Antarctic krill oil. This pure source of omega-3 fatty acids is clinically-studied to be more effective than fish oil, without the fishy aftertaste.*
- Efficient Joint Support: Krill phospholipids bind to omega-3s to maximize efficient absorption so your joints get the support they need. Feel an easier time moving around thanks to more flexible joints, and reduced soreness. *
- Powerful Antioxidant Activity: KrillMD contains astaxanthin, a powerful antioxidant that works to reduce common types of oxidative stress in the body for optimal joint, heart, and brain health.*
- Long-Term Heart Health: EPA, the highly potent omega-3 in krill oil, helps maintain normal cholesterol levels. The combination with the antioxidant benefits of astaxanthin helps you support heart health now and later.*
- Brain Health Support: Another powerful omega-3 fatty acid, DHA, helps support proper brain function. With regular supplementation, studies have found that krill oil helps promote memory, mood, and cognitive function.*
This premium Antarctic krill oil delivers EPA and DHA in phospholipid form with natural astaxanthin for superior absorption and antioxidant protection.
1MD Nutrition sources pure Antarctic krill oil containing EPA and DHA bound to phospholipids, which research suggests offers enhanced bioavailability compared to traditional fish oil triglycerides. The natural astaxanthin in krill oil provides powerful antioxidant benefits while giving the oil its distinctive red color. Smaller softgels are easier to swallow and have minimal fishy aftertaste.
What We Like
- Phospholipid-bound EPA/DHA for better absorption
- Natural astaxanthin provides antioxidant benefits
- Smaller softgels easier to swallow
What Could Be Better
- More expensive per milligram than fish oil
- Not suitable for those with shellfish allergies
Bottom Line: An excellent alternative for those seeking enhanced EPA and DHA absorption with the unique benefits of krill oil.
8. ZEBORA CoQ10 with Omega-3 — Best Heart Health Combo
- ENHANCED COQ10 WITH PQQ: Our CoQ10 400mg, with a 120-day supply, boosts natural CoQ10 levels for heart health. Combined with PQQ, it enhances mitochondrial energy production, vital for efficient energy and optimal heart function
- HIGH BIOAVAILABILITY: ZEBORA CoQ10 is enhanced with Black Pepper Extract and Sunflower Lecithin for superior absorption and bioavailability. Black Pepper offers antioxidant benefits, while sunflower lecithin supports skin and liver health
- OPTIMAL COMBINED OMEGA-3: Every Coq10 softgel contains 60 mg of omega-3s, which are imperative to promoting heart health. Omega-3s can improve sleep quality, support the eyes, skin, and brain health. Better absorption, better taste, and no fishy burps
- BENEFITS FOR STATIN USERS: CoQ10 is crucial for producing 95% of your body's energy, but levels decline with statin use. Supplementing with CoQ10 during statin therapy helps replenish lost levels, supporting energy production and overall organ function
- NATURAL AND PURE: All our products are third-party tested and are manufactured in a cGMP-certified facility. No Artificial Flavors or Sweeteners, No Sugar, No Starch, No Gluten, No Soy, No Wheat, and Sodium-free
This unique formula combines omega-3s with 400mg of CoQ10, plus PQQ and BioPerine for comprehensive cardiovascular support.
ZEBORA pairs omega-3 fatty acids with a substantial 400mg dose of coenzyme Q10, an essential nutrient for cellular energy production and heart health. The formula also includes PQQ (pyrroloquinoline quinone) for mitochondrial support and BioPerine to enhance nutrient absorption. This comprehensive blend addresses multiple aspects of cardiovascular wellness in a single supplement.
What We Like
- Combines EPA/DHA with high-dose CoQ10
- Includes PQQ and BioPerine for added benefits
- Addresses energy and cardiovascular health
What Could Be Better
- Lower EPA/DHA concentration than pure fish oils
- Premium pricing for multi-ingredient formula
Bottom Line: An intelligent choice for those wanting omega-3s combined with CoQ10 for comprehensive heart health support.
How to Choose the Best EPA DHA Supplement
The actual EPA and DHA content should be your primary focus, not just total omega-3 or fish oil amounts. Many labels prominently display “1000mg Fish Oil” but contain only 300mg of EPA and DHA combined. Always check the supplement facts panel for specific EPA and DHA amounts. For general health maintenance, aim for at least 500-1,000mg combined EPA and DHA daily. For targeted cardiovascular or cognitive support, therapeutic doses typically range from 1,000-2,000mg or higher.
The molecular form dramatically affects how well your body absorbs and utilizes EPA and DHA. Triglyceride forms (both natural and re-esterified) generally offer superior absorption compared to ethyl ester forms commonly found in cheaper supplements. Re-esterified triglycerides undergo additional processing to optimize the molecular structure for bioavailability. Phospholipid-bound omega-3s from krill represent another highly absorbable option. When comparing products, check whether they specify the molecular form—quality manufacturers are transparent about this.
Purity and quality testing are non-negotiable for fish oil supplements. Look for products that are molecularly distilled or undergo similar purification processes to remove mercury, PCBs, dioxins, and other environmental contaminants. Third-party certifications from organizations like IFOS (International Fish Oil Standards), NSF, or USP verify that products meet strict purity standards and contain the labeled amounts of EPA and DHA. These certifications add cost but provide crucial quality assurance.
Consider the EPA to DHA ratio based on your specific health goals. Balanced formulas provide roughly equal amounts of both, supporting general wellness. Higher EPA formulas (2:1 or 3:1 EPA to DHA) are often recommended for cardiovascular health and anti-inflammatory support. Higher DHA formulas benefit brain health, cognitive function, and eye health. Some products target specific ratios for particular health outcomes, so match the formula to your primary wellness objectives.
Freshness indicators help ensure you’re getting effective omega-3s. Check expiration dates and look for products packaged in dark bottles or blister packs that protect against light and air exposure. Some quality manufacturers include the “totox” (total oxidation) value—lower numbers indicate fresher oil. Enteric-coated softgels or added antioxidants like vitamin E help preserve freshness and reduce fishy aftertaste. Refrigerating your supplements after opening can extend their shelf life.
Benefits of EPA DHA Supplements
EPA and DHA provide distinct yet complementary health benefits throughout the body. EPA particularly shines in cardiovascular support, helping maintain healthy triglyceride levels, supporting appropriate inflammatory responses, and contributing to endothelial function—the health of blood vessel linings. DHA concentrates in brain tissue and the retina, making it crucial for cognitive function, memory, and eye health. Together, these omega-3s support cellular membrane fluidity, allowing cells to function optimally.
The cardiovascular benefits of EPA and DHA are extensively researched and well-established. These omega-3s help reduce triglyceride levels by 15-30% at therapeutic doses, support healthy blood pressure already within normal range, and help maintain appropriate platelet function for healthy blood clotting. The anti-inflammatory effects of EPA may help moderate the inflammation involved in atherosclerosis and other cardiovascular conditions. Multiple studies associate higher EPA and DHA intake with better overall heart health outcomes.
Brain and cognitive benefits of DHA are particularly pronounced, as this omega-3 comprises about 40% of the polyunsaturated fatty acids in the brain. Adequate DHA supports neurotransmitter function, neural plasticity, and the formation of new brain cells. Research links higher DHA levels to better memory performance, processing speed, and overall cognitive function. EPA contributes to mood regulation and emotional wellness, with some studies suggesting benefits for mood support when combined with DHA.
Beyond cardiovascular and cognitive health, EPA and DHA support systemic wellness. They help maintain healthy inflammatory responses throughout the body, which impacts joint comfort, skin health, and immune function. DHA is crucial for eye health, comprising a significant portion of retinal tissue. Both omega-3s support cell membrane integrity and fluidity, affecting how cells communicate and respond to signals. This fundamental cellular support creates far-reaching benefits across multiple body systems.
Frequently Asked Questions
What’s the difference between EPA and DHA?
EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid) are both omega-3 fatty acids but serve different primary functions. EPA particularly supports cardiovascular health, anti-inflammatory responses, and mood regulation. DHA concentrates in brain tissue and eyes, making it crucial for cognitive function, memory, and vision. While they work synergistically, their distinct roles explain why some supplements emphasize one over the other for targeted health goals.
How much EPA and DHA should I take daily?
For general health maintenance, aim for 250-500mg combined EPA and DHA daily. For cardiovascular support, most research uses 1,000-2,000mg combined per day. Higher doses of 2,000-4,000mg may benefit those with elevated triglycerides, but these therapeutic amounts should be taken under medical supervision. The optimal dose varies based on individual health status, dietary fish intake, and specific health goals.
Can I get enough EPA and DHA from diet alone?
You can obtain adequate EPA and DHA by eating fatty fish like salmon, mackerel, sardines, or herring 2-3 times weekly. However, many people don’t maintain this frequency consistently, making supplementation helpful. A blood test measuring omega-3 index can determine if your dietary intake meets your needs. Vegetarians and vegans can get ALA (another omega-3) from plant sources, but conversion to EPA and DHA is inefficient, making algae-based supplements beneficial.
When is the best time to take EPA DHA supplements?
Take EPA and DHA supplements with meals containing some fat, as dietary fat enhances absorption of these fat-soluble nutrients. Many people prefer taking them with their largest meal to minimize any fishy aftertaste. Splitting your dose between morning and evening meals can help maintain steady blood levels. Consistency matters more than specific timing—taking them at the same time daily supports habit formation.
Can EPA and DHA supplements interact with medications?
EPA and DHA can affect blood clotting, so consult your healthcare provider before combining supplements with anticoagulants or antiplatelet medications like warfarin, aspirin, or clopidogrel. They may also interact with blood pressure medications by having additive effects. While these interactions aren’t necessarily harmful, your doctor may need to adjust medication dosages or provide specific monitoring. Always disclose supplement use to all your healthcare providers.
Do EPA DHA supplements cause fishy burps?
Some people experience fishy aftertaste or burps with fish oil supplements, though this is less common with high-quality products. Enteric-coated softgels release the oil in your intestines rather than stomach, virtually eliminating this issue. Taking supplements with food, freezing them before use, or choosing liquid formulas with added flavoring can also help. If fishy burps persist, it may indicate the oil is oxidizing and you should try a fresher product.
How do I know if my EPA DHA supplement is high quality?
Look for third-party testing certifications from IFOS, NSF, or USP that verify purity and potency. Check that the label clearly states EPA and DHA amounts (not just total omega-3). Quality products specify the molecular form (triglyceride, re-esterified TG, or ethyl ester) and manufacturing process (molecularly distilled). Fresh supplements shouldn’t smell strongly fishy. Reputable brands are transparent about their sourcing, testing, and quality standards.
Can I take too much EPA and DHA?
While EPA and DHA are generally safe, very high doses above 3-4 grams daily may increase bleeding risk or affect immune function. Doses above 3 grams should be taken under medical supervision, especially if you’re on blood thinners or have upcoming surgery. Most people tolerate 1-2 grams daily well without issues. The FDA considers up to 3 grams per day from supplements safe for most people, but individual needs vary.
