Best GLP-1 Support Supplements (2026) – Top 10 Reviewed
GLP-1 support supplements have exploded in popularity as natural alternatives to prescription medications like Ozempic and Wegovy. These formulas use ingredients like berberine and Akkermansia probiotics to support your body’s natural appetite and metabolism regulation.
The best options combine multiple proven ingredients with good absorption and minimal stomach discomfort. Here are our top 10 picks for 2026.
Quick Comparison
| Product | Key Ingredients | Servings | Form | Best For |
|---|---|---|---|---|
| GLP-1 17-in-1 Formula | Berberine, Akkermansia | 90 | Gummies | Best Overall |
| GLP Activate Natural Formula | Natural GLP-1 activators | 60 | Capsules | Best Value |
| Humann SuperBerine | Berberine, Olive Leaf | 30 | Capsules | Best High-Absorption |
| Vitamin Bounty Tune Your Keto | Magnesium, Potassium, GLP-1 Support | 90 | Capsules | Best for Keto Dieters |
| Akkermansia GLP-1 Probiotic | Akkermansia, Berberine, Beta-Glucan | 60 | Capsules | Best Probiotic Formula |
| Sousti GLP Activate | Natural GLP-1 activators | 60 | Capsules | Best Budget Option |
| GLP-1 15-in-1 Complex Powder | Probiotics, Appetite Support | 30 | Powder Packets | Best Powder Formula |
| Legendairy Milk Sugar Babe | Dihydroberberine | 60 | Capsules | Best for Carb Management |
| Ceylon Cinnamon Berberine Gummies | Berberine, Ceylon Cinnamon, Chromium | 120 | Gummies | Best Sugar-Free Gummies |
| Bio.me GLP-1 Support Powder | Fiber, Collagen, Digestive Enzymes | 24 | Powder | Best for Digestive Health |
1. GLP-1 17-in-1 Formula – Best Overall
Why it stands out: This comprehensive formula combines 17 active ingredients including berberine and Akkermansia probiotics in an easy-to-take gummy format. It’s designed to support natural GLP-1 production without the stomach discomfort common with many berberine supplements.
The 17-in-1 formula addresses GLP-1 support from multiple angles—metabolism, gut health, and nutrient absorption. Each serving provides clinically relevant doses of berberine alongside Akkermansia, a probiotic strain that has emerged as one of the most promising for metabolic health in recent research. The combination approach is smart because GLP-1 production involves multiple body systems working together.
What sets this apart from basic berberine supplements is the focus on tolerability. Many people quit berberine because of stomach upset, but the gummy delivery system and supporting ingredients help minimize these issues. The 90-count bottle provides a full month’s supply when taken as directed, and the pleasant taste makes it something you’ll actually look forward to taking rather than dreading.
Pros:
- Comprehensive 17-ingredient formula targeting multiple pathways
- Includes both berberine and Akkermansia probiotics
- Pleasant gummy format with minimal stomach discomfort
- 90-count bottle provides excellent value for a multi-ingredient formula
Cons:
- Higher price point than single-ingredient options
- Gummies require 3 per serving
Best for: Anyone wanting a comprehensive GLP-1 support formula that’s easy to take daily without digestive side effects.
2. GLP Activate Natural Formula – Best Value
Why it stands out: GLP Activate delivers a straightforward natural formula designed to be taken before meals for optimal GLP-1 support. It focuses on metabolic energy and overall health without unnecessary filler ingredients.
This capsule-based formula is designed for pre-meal use, which aligns with how your body naturally produces GLP-1 in response to food. The 60-capsule count provides a full month’s supply at a competitive price point. Users appreciate the simplicity of the formula and the noticeable effects on appetite when taken 20-30 minutes before eating.
Pros:
- Simple, effective formula
- Designed for pre-meal timing
- Good value per serving
- Easy-to-swallow capsules
Cons:
- Requires timing with meals for best results
Best for: Those who prefer a straightforward approach and don’t mind timing their supplements with meals.
3. Humann SuperBerine – Best High-Absorption
Why it stands out: Humann’s SuperBerine uses a clinically researched, high-absorbency berberine formula combined with olive leaf extract. This concentrated dose approach means you need fewer capsules to get effective results.
Standard berberine has notoriously poor bioavailability—studies suggest only about 5% of regular berberine actually reaches your bloodstream. Humann addresses this fundamental problem with an enhanced absorption formula, meaning each capsule delivers substantially more active berberine to your system than standard supplements at equivalent doses. This is why high-quality berberine supplements often outperform cheaper options despite similar label claims.
The addition of olive leaf extract isn’t just filler—it provides complementary antioxidant and metabolic support that may enhance berberine’s effects. The one-capsule daily dosing is ideal for people who struggle with supplement compliance or simply don’t want another multi-pill regimen to manage. Humann is a well-established brand known for rigorous third-party testing, which adds confidence in what you’re actually getting.
Pros:
- Clinically researched high-absorption berberine formula
- Includes olive leaf extract for synergistic support
- Simple one capsule daily dosing
- Reputable brand with transparent quality testing
Cons:
- Smaller bottle size at 30 count (one month supply)
- Premium pricing reflects absorption technology
Best for: Those who’ve tried standard berberine without results, or anyone wanting maximum absorption from fewer capsules.
4. Vitamin Bounty Tune Your Keto – Best for Keto Dieters
Why it stands out: This unique multivitamin combines GLP-1 support with magnesium and potassium—two minerals commonly depleted on ketogenic diets. It’s designed specifically for people following low-carb eating plans.
Keto dieters often experience muscle cramps and energy dips due to electrolyte loss, and this formula addresses both issues while supporting metabolic health. The 90-capsule count provides excellent value, and the combination approach means fewer bottles cluttering your supplement cabinet. The GLP-1 support ingredients complement the natural appetite suppression many experience on keto.
Pros:
- Addresses multiple keto-related needs in one formula
- Includes magnesium and potassium for cramp relief
- 90-count bottle offers good value
- Supports ketosis alongside GLP-1
Cons:
- Best suited for those on keto or low-carb diets
- Contains multiple ingredients that may not suit minimalists
Best for: Anyone following a ketogenic or low-carb diet who wants comprehensive metabolic support.
5. Akkermansia GLP-1 Probiotic – Best Probiotic Formula
Why it stands out: This formula combines Akkermansia muciniphila—a probiotic strain specifically linked to GLP-1 production—with berberine and prebiotic fiber. The delayed-release capsules ensure the probiotics survive stomach acid to reach your intestines where they work.
Akkermansia muciniphila has emerged as perhaps the most important probiotic for metabolic health. Research shows that people with healthy metabolisms tend to have higher levels of this bacteria, while those struggling with weight often have depleted populations. Unlike other probiotics that focus on digestive symptoms, Akkermansia specifically supports the gut lining and influences how your body produces and responds to GLP-1.
This formula provides 3 billion AFU (active fluorescent units) of Akkermansia alongside berberine and beta-glucan prebiotic fiber. The prebiotic fiber isn’t just filler—it feeds the Akkermansia and helps it establish in your gut more effectively. The delayed-release capsule technology is crucial here, as stomach acid would destroy most probiotics before they reach the intestines. The two-month supply at 60 capsules makes this economical for the long-term use probiotics require.
Pros:
- Contains clinically relevant Akkermansia dose at 3 billion AFU
- Delayed-release capsules protect probiotics from stomach acid
- Includes beta-glucan prebiotic fiber for better colonization
- Two-month supply provides value for consistent use
Cons:
- Probiotics require consistent daily use over weeks for best results
- May take 8-12 weeks to notice significant effects
Best for: Those interested in the gut microbiome connection to GLP-1 and willing to commit to consistent long-term probiotic use.
6. Sousti GLP Activate – Best Budget Option
Why it stands out: Sousti offers a natural GLP-1 support formula at one of the most accessible price points in the category. It provides the core benefits without the premium price tag.
This formula focuses on the essentials for GLP-1 support, designed for pre-meal use to support metabolic function and energy. The 60-capsule count provides a full month’s supply, making it easy to budget. While it doesn’t have as many ingredients as premium options, users report solid results for appetite management and metabolic support.
Pros:
- Most affordable option in the category
- Full month’s supply
- Simple, focused formula
- Suitable for both men and women
Cons:
- Fewer ingredients than premium formulas
- Less comprehensive than multi-ingredient options
Best for: Budget-conscious shoppers who want to try GLP-1 support without a major investment.
7. GLP-1 15-in-1 Complex Powder – Best Powder Formula
Why it stands out: This powder format offers 15 active ingredients in convenient single-serving packets. It’s ideal for those who dislike swallowing pills or want to mix their supplements into smoothies.
The powder format allows for better absorption since ingredients don’t need to dissolve from a capsule first. Each packet contains probiotics for gut health alongside appetite-supporting compounds and metabolism boosters. The individual serving packets make it easy to take on-the-go and ensure consistent dosing. Many users mix it into their morning protein shake or smoothie.
Pros:
- Convenient single-serving packets
- Potentially better absorption than capsules
- 15 active ingredients
- Easy to mix into drinks
Cons:
- Less convenient than capsules for some users
- Requires mixing with liquid
- 30 servings per container
Best for: Those who prefer powder supplements or have difficulty swallowing capsules.
8. Legendairy Milk Sugar Babe – Best for Carb Management
Why it stands out: Sugar Babe uses dihydroberberine, a more bioavailable form of berberine, specifically formulated to help manage cravings and support healthy carbohydrate metabolism without the harsh GI effects of standard berberine.
Dihydroberberine is the active metabolite that berberine converts to in your body—essentially, it’s already in the form your body actually uses. This means you absorb it more efficiently and need lower doses to achieve similar effects, which significantly reduces the stomach upset that makes many people abandon berberine supplements entirely. Research suggests dihydroberberine may be up to five times more bioavailable than standard berberine.
The formula specifically targets cravings and carbohydrate metabolism, making it particularly useful for those struggling with sugar addiction or frequent carb cravings that derail their dietary efforts. Legendairy Milk is a trusted brand known primarily for their breastfeeding supplements, and they bring that same quality focus to this metabolic support product. The one-month supply keeps the price accessible for testing whether this approach works for you.
Pros:
- Uses superior dihydroberberine for better absorption
- Specifically designed to target cravings and carb metabolism
- Much gentler on the stomach than standard berberine
- From Legendairy Milk, a brand known for quality
Cons:
- More focused formula—less comprehensive than multi-ingredient options
- 60 capsules may require 2 per day depending on dosing
Best for: Those specifically struggling with sugar or carb cravings who want gentler berberine support.
9. Ceylon Cinnamon Berberine Gummies – Best Sugar-Free Gummies
Why it stands out: These gummies combine a substantial 2000mg berberine dose with Ceylon cinnamon, chromium, and magnesium glycinate—all in a sugar-free formula that won’t spike your blood glucose while you’re trying to manage it.
The combination of berberine with Ceylon cinnamon creates a synergistic effect for blood sugar management that neither ingredient achieves as effectively alone. Ceylon cinnamon is specifically important—it’s the “true” cinnamon variety with metabolic benefits, unlike the cheaper Cassia cinnamon in most supplements that can actually be problematic in high doses. Adding chromium (which supports insulin sensitivity) and magnesium glycinate (which supports hundreds of metabolic reactions) rounds out a comprehensive formula.
At 120 gummies per bottle, this provides genuine value—many gummy supplements skimp on count to hit price points. The sugar-free formulation is absolutely crucial here. It makes no sense to take a blood sugar support supplement that contains added sugars, yet many gummy products do exactly that. These use sugar-free sweetening that won’t undermine your metabolic goals.
Pros:
- High-dose 2000mg berberine per serving
- Truly sugar-free formula won’t spike blood glucose
- Includes Ceylon cinnamon (not Cassia), chromium, and magnesium
- Large 120-count bottle provides excellent value
Cons:
- Gummies require multiple pieces per serving
- Taste and texture may not appeal to everyone
Best for: Those who want a comprehensive gummy formula without the added sugars that defeat the purpose.
10. Bio.me GLP-1 Support Powder – Best for Digestive Health
Why it stands out: Bio.me takes a different approach, combining 7g of fiber and 14g of collagen protein with digestive enzymes to support both GLP-1 production and overall gut health.
Fiber is one of the most effective natural stimulators of GLP-1 release, and this formula delivers a meaningful 7g dose alongside collagen protein for gut lining support. The digestive enzymes help ensure you’re absorbing nutrients efficiently. The raspberry flavor makes it pleasant to drink, and the combination of fiber and protein helps with satiety. At 24 servings, it’s best viewed as a premium option for those wanting digestive support alongside GLP-1 benefits.
Pros:
- Substantial 7g fiber dose
- Includes 14g collagen protein
- Digestive enzymes for better absorption
- Pleasant raspberry flavor
Cons:
- Fewer servings per container (24)
- Requires mixing into liquid
- Higher cost per serving
Best for: Those wanting to combine GLP-1 support with fiber, protein, and digestive health benefits.
What is GLP-1 and Who Should Take It?
GLP-1 (glucagon-like peptide-1) is an incretin hormone your body naturally produces in response to eating, particularly when food reaches your small intestine. It plays a crucial role in appetite regulation by signaling your brain that you’re satisfied, slowing gastric emptying so you feel full longer, and helping regulate blood sugar levels by stimulating insulin release when needed. Prescription GLP-1 medications like semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro) have revolutionized weight management by mimicking this hormone at much higher levels.
GLP-1 support supplements work differently—they don’t contain the hormone itself or synthetic versions of it. Instead, they use ingredients that help your body produce GLP-1 more effectively or respond to it better. Berberine, for example, appears to activate similar metabolic pathways that GLP-1 uses. Akkermansia probiotics support the gut lining cells (L-cells) that produce GLP-1. Fiber triggers natural GLP-1 release by feeding gut bacteria and stimulating intestinal receptors.
These supplements are best suited for people looking to support healthy appetite and metabolism through natural means—particularly those who aren’t candidates for prescription medications, want to try natural approaches first, or are looking for complementary support alongside lifestyle changes. They won’t produce the dramatic results of prescription medications, but they offer gentler support with fewer side effects for gradual, sustainable metabolic improvement.
How to Choose the Right GLP-1 Support Supplement
Key Ingredients to Look For
The most effective GLP-1 support supplements typically contain one or more proven ingredients with meaningful research behind them. Berberine remains the gold standard, with effective doses ranging from 500-1500mg daily—look for forms specifically enhanced for absorption like dihydroberberine or phytosome technology, as standard berberine has poor bioavailability. Akkermansia muciniphila should provide at least 1 billion AFU in delayed-release capsules that protect the bacteria from stomach acid.
Supporting ingredients that complement these primary compounds include chromium (200-400mcg for insulin sensitivity), Ceylon cinnamon (not Cassia variety), alpha-lipoic acid, and prebiotic fiber. Fiber deserves special mention—it’s one of the most effective natural GLP-1 stimulators, yet most Americans consume far less than the recommended 25-35g daily. Supplements providing meaningful fiber doses (5g+) offer genuine value beyond just convenience.
Forms Compared
Capsules are the most common format and generally offer precise dosing with minimal fillers. They’re convenient for travel and easy to incorporate into existing supplement routines. Standard capsules work well for berberine, though delayed-release versions are essential for probiotics.
Gummies provide an easier-to-take option for those who struggle with pills, but they require trade-offs. You’ll typically need 2-4 gummies to match one capsule dose, and many contain added sugars that undermine metabolic goals—always verify “sugar-free” formulations. Quality varies significantly in the gummy category.
Powders potentially offer the best absorption since ingredients don’t need to dissolve from a capsule first. They’re ideal for adding to smoothies or protein shakes, making them easy to integrate into morning routines. However, they’re less convenient for travel and require mixing.
What to Avoid
Skip supplements with proprietary blends that hide individual ingredient amounts—if a label just says “metabolic support blend 800mg” without listing individual doses, you have no way to verify you’re getting effective amounts. Be wary of unrealistic claims about rapid weight loss or “natural Ozempic”—supplements work differently and more gradually than medications.
Very low-cost options with no third-party testing are a red flag, as berberine in particular is frequently found to contain less active compound than labels claim. Standard berberine (rather than enhanced absorption forms) may cause significant digestive issues in sensitive individuals—if you’ve tried berberine before and quit due to stomach problems, consider dihydroberberine formulas instead.
Side Effects and Precautions
The most common side effects of GLP-1 support supplements relate to berberine, the most potent active ingredient in most formulas. These include gastrointestinal discomfort (cramping, bloating, diarrhea, constipation), nausea, and in some cases headaches—particularly when starting supplementation or at higher doses. These effects typically diminish over 1-2 weeks as your body adjusts. Starting with a lower dose (250-500mg) and taking with food significantly reduces the likelihood of digestive issues. Splitting doses throughout the day rather than taking all at once also helps.
Dihydroberberine and enhanced-absorption berberine formulas cause notably fewer GI problems than standard berberine because lower doses achieve similar effects. If you’ve tried berberine before and quit due to stomach problems, these alternatives are worth considering. Probiotic-focused formulas like those containing Akkermansia rarely cause significant side effects, though temporary bloating or gas can occur as gut bacteria populations shift.
Several groups should consult their healthcare provider before using GLP-1 support supplements. Berberine can lower blood sugar, creating potential interactions with diabetes medications—particularly metformin, sulfonylureas, and insulin. The combination could cause hypoglycemia (dangerously low blood sugar). Berberine also interacts with several other drug classes: it may increase levels of some statins, reduce effectiveness of certain antibiotics, and interact with blood pressure medications and immunosuppressants.
Pregnant and nursing women should avoid most GLP-1 support supplements, as berberine’s safety hasn’t been established in these populations. Anyone scheduled for surgery should stop berberine supplements at least two weeks beforehand due to potential blood sugar and blood clotting effects. Those with low blood pressure should use caution, as some ingredients may further reduce blood pressure.
FAQs
How much berberine should I take for GLP-1 support? Most clinical research uses 500mg two to three times daily with meals, totaling 1000-1500mg per day. However, starting at this dose often causes stomach upset. A smarter approach is beginning with 500mg once daily for the first week, then adding a second dose if tolerated, and potentially a third after another week. If using dihydroberberine, effective doses are typically 100-200mg since it’s 3-5 times more bioavailable.
When is the best time to take GLP-1 support supplements? Most GLP-1 support supplements work best when taken 20-30 minutes before meals, as this timing aligns with when your body naturally ramps up GLP-1 production in response to eating. Berberine specifically should be taken with food to improve absorption and significantly reduce the likelihood of stomach upset. For probiotics like Akkermansia, consistency matters more than timing—take them at whatever time you’ll remember daily, though many people find mornings easier to maintain.
How long does it take to see results from GLP-1 supplements? Most people notice effects on appetite and cravings within two to four weeks of consistent daily use. Metabolic markers like fasting blood sugar typically require six to eight weeks of consistent supplementation to show measurable changes on bloodwork. Probiotic-based formulas work more slowly—expect eight to twelve weeks minimum for the bacteria to establish sufficient populations in your gut to influence GLP-1 production meaningfully. Unlike prescription medications, these supplements require patience and consistency.
Can GLP-1 supplements cause stomach problems? Berberine is notorious for causing digestive upset in some people, particularly at higher doses or when first starting. Common complaints include nausea, cramping, diarrhea, and bloating. These issues affect roughly 10-20% of users with standard berberine. Strategies to minimize problems include: choosing dihydroberberine or enhanced-absorption formulas (significantly fewer GI issues), always taking with food, starting at low doses and gradually increasing, and splitting doses throughout the day rather than taking all at once. If problems persist beyond 2-3 weeks, consider switching to probiotic-focused formulas instead.
Are GLP-1 supplements safe to take with medications? Berberine has clinically significant interactions with several medication classes. With diabetes drugs (metformin, sulfonylureas, insulin), it may cause dangerous hypoglycemia. It can increase blood levels of some statins by interfering with their metabolism. It may reduce effectiveness of certain antibiotics (macrolides, fluoroquinolones) and interact with immunosuppressants like cyclosporine. Blood pressure medications may also interact. This isn’t a complete list—always consult your pharmacist or healthcare provider before combining berberine supplements with any prescription medications. Probiotic-focused supplements generally have fewer drug interactions.
Do GLP-1 supplements actually work like Ozempic? No—these supplements work through entirely different mechanisms and produce much more modest effects. Prescription GLP-1 medications like Ozempic inject synthetic versions of the GLP-1 hormone directly into your body at levels far higher than natural production. Supplements instead support your body’s own GLP-1 production through various indirect mechanisms—berberine activates similar metabolic pathways, Akkermansia supports the cells that produce GLP-1, and fiber triggers natural GLP-1 release. Expect gradual, supportive effects on appetite and metabolism, not the dramatic results of prescription medications. Think of these supplements as part of a healthy lifestyle approach rather than pharmaceutical-level intervention.
Final Verdict
For most people, the GLP-1 17-in-1 Formula offers the best combination of proven ingredients, convenience, and stomach-friendly delivery in its gummy format. If you’re on a budget, Sousti GLP Activate provides solid basic support at an accessible price point.
For those interested in the gut-health approach, the Akkermansia GLP-1 Probiotic offers a research-backed probiotic option, though it requires patience for results. And if you’re on a keto diet, Vitamin Bounty Tune Your Keto addresses multiple needs in one formula.
Remember that GLP-1 support supplements work best as part of a healthy lifestyle—they’re not magic pills but rather tools to support your body’s natural appetite and metabolism regulation.
