Best Grape Seed Extract Supplements (2026) – Top 10 Reviewed
Grape seed extract has become one of the most popular antioxidant supplements for supporting cardiovascular health, skin vitality, and overall wellness. Rich in oligomeric proanthocyanidins (OPCs), these powerful plant compounds offer protection against oxidative stress and support healthy circulation.
The best grape seed extracts are standardized for high polyphenol content (90-95%) and use concentrated extracts for maximum potency. Here are our top 10 picks for 2026.
| Product | Key Ingredients | Servings | Form | Best For |
|---|---|---|---|---|
| Zazzee Grape Seed 50:1 Extract | 400mg (95% Polyphenols) | 180 | Capsules | Best Overall |
| NOW Grape Seed Extract 500mg | 500mg (90% Polyphenols) | 90 | Capsules | Best Value |
| Nutricost Grape Seed Extract | 28,000mg equivalent | 240 | Capsules | Best Budget Option |
| Thorne Grape Seed Extract | 100mg Phytosome | 60 | Capsules | Best Premium |
| Terry Naturally Clinical OPC | 400mg French VX1 | 60 | Softgels | Best Absorption |
| Carlyle Grape Seed Extract | 24,000mg equivalent | 240 | Capsules | Best Bulk Supply |
| Bronson Grape Seed Extract | 400mg (95% Proanthocyanidins) | 180 | Capsules | Best for Immune Support |
| Pure Synergy SuperPure Grape Seed | Organic Grape Seed + Pomace | 60 | Capsules | Best Organic |
| Zazzee French Maritime Pine Bark | 350mg (95% Proanthocyanidins) | 180 | Capsules | Best OPC Alternative |
| Micro Ingredients Grape Seed Extract | 1600mg + Resveratrol | 180 | Capsules | Best Antioxidant Blend |
1. Zazzee Grape Seed 50:1 Extract – Best Overall
Why it stands out: Zazzee delivers exceptional potency with a concentrated 50:1 extract standardized to 95% polyphenols, providing 20,000mg equivalent strength per capsule. The six-month supply offers outstanding value for a premium-quality product, and customer reviews consistently praise its effectiveness for cardiovascular and skin support.
Each capsule contains 400mg of highly concentrated grape seed extract with the highest polyphenol standardization available (95%). The extraction process ensures maximum bioavailability and absorption, delivering potent OPCs that support cardiovascular health, skin vitality, and immune function. Users frequently report improvements in varicose vein discomfort, joint pain, and blood pressure readings within weeks of consistent use.
At just one capsule daily, the 180-count bottle provides exceptional long-term value—one of the best cost-per-serving ratios in the premium category. All ingredients are 100% vegan, non-GMO, and manufactured in a USA cGMP-certified facility. The company offers a lifetime money-back guarantee, demonstrating confidence in their product quality.
Pros:
- Highest polyphenol concentration (95%) on the market
- 6-month supply in one bottle
- Vegan, non-GMO, made in USA
- No artificial fillers or additives
Cons:
- Higher price point than basic extracts
Best for: Anyone wanting maximum-strength grape seed extract with verified potency and long-term value.
2. NOW Grape Seed Extract 500mg – Best Value
Why it stands out: NOW Foods delivers a trusted, high-potency formula with 500mg per capsule and minimum 90% polyphenols. The brand’s 50+ year reputation for quality makes this an excellent choice for value-conscious buyers seeking maximum strength from an established name.
This maximum-strength formula contains twice the grape seed extract of NOW’s extra-strength version (250mg), providing powerful OPC support for vascular, bone, kidney, and brain health. The highly concentrated extract delivers potent water-soluble free radical scavenging compounds that research indicates may help support a healthy, balanced immune response to metabolic stress.
NOW’s rigorous GMP manufacturing and third-party testing ensure consistent quality batch after batch. The product is vegan, kosher, non-GMO, and free from common allergens including gluten, soy, dairy, and nuts—making it accessible for those with multiple food sensitivities. Family-owned since 1968, NOW Foods has built their reputation on quality and transparency. Users appreciate the easy-to-swallow capsules and report noticeable improvements in energy levels and skin health.
Pros:
- Maximum strength 500mg per capsule
- Trusted brand with 50+ years experience
- Allergen-friendly (no gluten, soy, dairy, nuts)
- Kosher and vegan certified
Cons:
- Smaller bottle size (90 capsules)
Best for: Health-conscious consumers who want a reliable, high-potency grape seed extract from an established brand.
3. Nutricost Grape Seed Extract – Best Budget Option
Why it stands out: Nutricost offers an impressive 28,000mg equivalent per serving using a potent 70:1 extract, with 240 capsules per bottle providing up to 8 months of daily use at an unbeatable price point.
Each capsule delivers 400mg of 70:1 grape seed extract, equivalent to 28,000mg of grape seed powder. This is among the highest-potency formulas available at a budget-friendly price. The supplement is gluten-free, non-GMO, and vegetarian-friendly. All Nutricost products are manufactured in GMP-compliant, FDA-registered facilities and tested by independent ISO-accredited laboratories for safety and quality assurance.
Pros:
- Highest equivalent potency (28,000mg) in category
- 8-month supply per bottle
- Excellent price-per-serving
- Third-party tested for purity
Cons:
- Polyphenol percentage not specified on label
- Capsules may be larger than some competitors
Best for: Budget-conscious buyers who want maximum potency without compromising on quality.
4. Thorne Grape Seed Extract – Best Premium
Why it stands out: Thorne’s phytosome technology binds grape seed OPCs to phospholipids for significantly enhanced absorption. This clinical-grade formula is trusted by healthcare practitioners and professional athletes worldwide.
This premium formula uses Leucoselect Phytosome®, a patented complex that dramatically improves OPC bioavailability compared to standard extracts. Clinical studies show this form reduces LDL-cholesterol oxidation, decreases oxidative stress in diabetics, and supports healthy aging. Thorne is NSF Certified for Sport (testing for 200+ banned substances) and recommended by 100+ professional sports teams. The formula contains no unnecessary binders, fillers, or magnesium stearate.
Pros:
- Patented phytosome technology for superior absorption
- NSF Certified for Sport
- Recommended by healthcare practitioners
- Clinical research backing
Cons:
- Lower mg per capsule (100mg)
- Premium pricing
- Smaller bottle (60 capsules)
Best for: Athletes, health enthusiasts, and anyone prioritizing maximum absorption over raw potency.
5. Terry Naturally Clinical OPC Extra Strength – Best Absorption
Why it stands out: Clinical OPC features French grape seed extract VX1, backed by 6 scientific studies and standardized to contain ≥99% polyphenols and ≥80% OPCs—the highest purity available.
This formula uses only low-molecular-weight OPCs from French-grown grapes, ensuring optimal absorption. Unlike standard extracts that contain large, poorly-absorbed compounds, VX1 is tannin-free and delivers concentrated polyphenols directly to your cells. The softgel delivery with olive oil and sunflower lecithin further enhances bioavailability. Independent testing verifies this is genuine grape seed extract, not adulterated with cheaper peanut skin extracts common in the industry.
Pros:
- ≥99% polyphenols, ≥80% OPCs (highest available)
- French-grown grapes, verified authentic
- Tannin-free for better absorption
- Softgel form enhances bioavailability
Cons:
- Premium pricing
- Contains gelatin (not vegan)
Best for: Those seeking pharmaceutical-grade grape seed extract with verified purity and optimal absorption.
6. Carlyle Grape Seed Extract – Best Bulk Supply
Why it stands out: Carlyle offers 240 quick-release capsules delivering 24,000mg equivalent per serving, providing excellent value for those who want a long-term supply from a trusted family brand with 40+ years in supplements.
Each serving (3 capsules) provides the equivalent of 24,000mg grape seed powder from a 20:1 extract, standardized to contain 840mg of polyphenols. The quick-release capsules ensure rapid absorption. Carlyle’s products are laboratory-tested and manufactured with trusted ingredients under strict quality control. The formula is naturally free of gluten, wheat, artificial flavors, sweeteners, and preservatives.
Pros:
- 240 capsules per bottle
- High polyphenol content (840mg per serving)
- Quick-release capsules
- 40+ years of brand heritage
Cons:
- Requires 3 capsules per serving
- Contains gelatin
Best for: Those who prefer bulk buying and don’t mind taking multiple capsules per serving.
7. Bronson Grape Seed Extract – Best for Immune Support
Why it stands out: Bronson’s 400mg formula is standardized to exactly 95% proanthocyanidins (OPCs), the specific compounds most beneficial for immune function and antioxidant support.
Since 1960, Bronson has provided pharmacist-formulated supplements, and this grape seed extract continues that legacy. Each vegetarian capsule delivers 400mg of pure grape seed standardized to contain 95% polyphenols. The standardization ensures batch-to-batch consistency for reliable potency. All products are manufactured in Bronson’s FDA-registered, cGMP-certified facility in New York and undergo rigorous laboratory testing.
Pros:
- Exact 95% proanthocyanidin standardization
- 60+ year brand reputation
- Vegetarian capsules
- USA-made in cGMP facility
Cons:
- Standard potency compared to concentrated extracts
- May need 2 capsules for higher doses
Best for: Those specifically seeking immune and antioxidant support from a heritage American brand.
8. Pure Synergy SuperPure Grape Seed – Best Organic
Why it stands out: The only certified organic grape seed extract on our list, Pure Synergy combines organic Spanish grape seed extract with French whole grape pomace for comprehensive polyphenol support.
This formula is unique in combining 75% standardized OPCs from grape seeds with whole grape pomace (skin, stems, pulp) containing 17 different anthocyanin varieties. The grapes are sourced from pristine European vineyards using sustainable, zero-waste hot water extraction. Pure Synergy is a Certified B Corp based in Moab, Utah, committed to organic practices and environmental responsibility. The product is fully traceable from seed to bottle.
Pros:
- USDA Certified Organic
- Combines seed extract + whole fruit polyphenols
- Sustainable, zero-waste production
- Certified B Corp company
Cons:
- Lower OPC concentration than synthetic extracts
- Premium organic pricing
- Smaller bottle (60 capsules)
Best for: Health-conscious consumers who prioritize organic certification and whole-food sourcing.
9. Zazzee French Maritime Pine Bark Extract – Best OPC Alternative
Why it stands out: For those seeking similar benefits to grape seed extract, French maritime pine bark offers comparable OPCs with additional research supporting circulation and skin health.
This 20:1 extract delivers 350mg per capsule standardized to 95% proanthocyanidins. French maritime pine bark (Pinus pinaster) contains the same beneficial OPCs as grape seed but is sourced from the bark of pine trees grown along the French coast. Many users report synergistic benefits when combining pine bark with grape seed extract. The 180-capsule bottle provides a 6-month supply, and like all Zazzee products, it’s kosher, vegan, non-GMO, and made in the USA.
Pros:
- Alternative OPC source with unique benefits
- 95% proanthocyanidins standardization
- 6-month supply
- Can be combined with grape seed
Cons:
- Different polyphenol profile than grape seed
- Some users prefer grape seed specifically
Best for: Those looking to diversify their OPC sources or who have sensitivities to grape-derived products.
10. Micro Ingredients Grape Seed Extract with Resveratrol – Best Antioxidant Blend
Why it stands out: This comprehensive formula combines 1600mg grape seed extract with resveratrol, green tea, and quercetin for synergistic antioxidant support targeting multiple pathways.
Each serving delivers 1600mg of trans-resveratrol antioxidant blend including grape seed extract, green tea polyphenols, and quercetin. This multi-compound approach provides broader antioxidant coverage than single-ingredient formulas. The combination supports digestive health, heart health, immune function, and brain function. The 180-capsule bottle offers a 3-month supply at the recommended dosage of 2 capsules daily.
Pros:
- Multi-antioxidant formula for comprehensive support
- Includes resveratrol and green tea
- Synergistic polyphenol combination
- Good value for a complex formula
Cons:
- Lower grape seed concentration per capsule
- Requires 2 capsules per serving
- May not suit those wanting pure grape seed
Best for: Those seeking broad-spectrum antioxidant support rather than isolated grape seed benefits.
What is Grape Seed Extract and Who Should Take It?
Grape seed extract is a dietary supplement made by removing, drying, and pulverizing the seeds of wine grapes (Vitis vinifera). The seeds are rich in oligomeric proanthocyanidins (OPCs), powerful antioxidant compounds that support cellular health and protect against oxidative stress. In fact, grape seed extract is considered one of the best-known sources of proanthocyanidins, offering 20 times more antioxidant power than vitamin C and 50 times more than vitamin E according to some measurements.
The OPCs in grape seed extract work by neutralizing free radicals, supporting collagen cross-linking in skin and connective tissues, and helping maintain healthy capillary permeability. A 2020 review of 11 studies found that grape seed extract may help support healthy LDL cholesterol and triglyceride levels. Additionally, a 2022 review of 19 studies suggested benefits for diastolic blood pressure support.
Research suggests grape seed extract may benefit those concerned about cardiovascular health, skin aging, circulation issues, or general antioxidant support. It’s particularly popular among people looking to support healthy blood pressure levels already within normal range, maintain skin elasticity, and protect against environmental stressors. Athletes often use it for recovery support—clinical studies have shown reduced swelling and faster healing in athletes given OPCs before exercise. Older adults appreciate its potential cognitive and vascular benefits, while those concerned about skin aging value its collagen-supporting properties.
How to Choose the Right Grape Seed Extract
Key Ingredients to Look For
The most important factor is polyphenol standardization—look for products standardized to 90-95% polyphenols or proanthocyanidins (OPCs). Higher percentages indicate more of the beneficial active compounds per capsule. The term “standardized” means the manufacturer has verified that each batch contains a consistent amount of the active ingredient, which is crucial for reliable results.
Extract ratios like 50:1 or 70:1 indicate concentration levels. A 50:1 ratio means 50 pounds of raw grape seeds were used to produce 1 pound of extract, resulting in a much more potent product than non-concentrated powders. Higher ratios mean more grape seed material was used to create each capsule. Some products list “equivalent” dosages (like 20,000mg or 28,000mg) which represent how much raw grape seed would be needed to provide the same amount of active compounds.
Dosages typically range from 100-500mg per capsule, with most research supporting 150-300mg daily for general wellness. Some clinical studies have used higher doses up to 600mg for specific health goals. Look for products that clearly state both the extract amount and the polyphenol percentage—transparency here indicates quality manufacturing.
Forms Compared
Capsules and softgels are the most common delivery methods, each with distinct advantages. Standard vegetarian capsules work well for most users and are suitable for those avoiding animal products. Softgels (like those from Terry Naturally) contain the extract suspended in oil, which may enhance absorption of fat-soluble compounds and provide a smoother swallowing experience.
Phytosome formulations represent the premium tier of grape seed supplements. Products like Thorne’s use phospholipid complexes that dramatically improve bioavailability—some studies suggest phytosome delivery can increase absorption by 3-5 times compared to standard extracts. This technology comes at a higher price but may be worthwhile for those who’ve struggled to see results from conventional extracts.
Liquid extracts and tinctures exist but are less common for grape seed. They offer flexible dosing but may have stability concerns and shorter shelf lives. Powder forms provide versatility for those who want to add grape seed to smoothies or drinks, but require careful measuring and may have a bitter taste.
What to Avoid
Be cautious of products that don’t specify polyphenol content or standardization percentage—these may contain significant filler material with minimal active compounds. Watch for supplements that use “grape seed powder” rather than “grape seed extract,” as powders are far less concentrated and require much higher doses to achieve similar effects.
A concerning industry study found that many grape seed products are adulterated. Of 21 products tested, only 6 contained genuine potent grape seed extract, 9 were very low potency (likely diluted with peanut skin), and 6 contained no grape seed at all—only peanut skin extract, which could be dangerous for those with allergies. Stick with reputable brands that provide certificates of analysis and third-party testing.
Avoid products with excessive fillers like maltodextrin, artificial colors, titanium dioxide, or unnecessary additives. Check for allergen statements if you have sensitivities—some products contain soy-derived ingredients or are processed in facilities handling nuts.
Side Effects and Precautions
Grape seed extract is generally well-tolerated, with most people experiencing no adverse effects at standard doses (100-400mg daily). The most commonly reported side effects include mild digestive discomfort, nausea, headaches, dizziness, and itchy scalp. These effects are typically temporary and often resolve as your body adjusts to supplementation. Taking grape seed extract with food typically minimizes stomach upset, and starting with a lower dose before gradually increasing can help your body adapt.
Some individuals report feeling dehydrated or experiencing constipation when taking grape seed extract daily—staying well-hydrated and ensuring adequate fiber intake can help prevent these issues. Rarely, users may experience allergic reactions, particularly if they have known sensitivities to grapes, wine, or other fruits in the Vitis family.
Those taking blood thinners (warfarin, aspirin, clopidogrel), blood pressure medications, or NSAIDs should consult their healthcare provider before use, as grape seed may enhance these medications’ effects on blood clotting or blood pressure. The extract may also affect how the liver processes certain medications, potentially altering their effectiveness. If you take any prescription medications, discuss grape seed extract with your pharmacist or doctor.
Pregnant and breastfeeding women should avoid grape seed extract due to insufficient safety data during these periods. People with grape or wine allergies, as well as those with sensitivities to tannins, should exercise caution or consider alternative antioxidant supplements. Anyone scheduled for surgery should stop taking grape seed extract at least two weeks before the procedure due to its potential effects on bleeding time.
FAQs
What is the best dosage for grape seed extract?
Most research supports 150-300mg of standardized extract daily for general wellness and antioxidant support. Some studies investigating specific health conditions have used higher doses up to 600mg daily. Start with the lower end of the range and adjust based on your response and healthcare provider’s guidance. Concentrated extracts (50:1 or higher) deliver more active compounds per milligram than standard extracts.
When should I take grape seed extract?
Grape seed extract can be taken any time of day, though taking it with meals helps maximize absorption and minimize any potential digestive discomfort. Some users prefer morning dosing for a perceived energy boost, while others take it with dinner. Consistency matters more than timing—choose a schedule you’ll stick with long-term.
How long does it take to see results from grape seed extract?
Many users notice subtle improvements in energy and skin appearance within 2-4 weeks of consistent daily use. More significant benefits for circulation, cardiovascular markers, and visible skin improvements typically appear after 8-12 weeks. Patience is key—antioxidant supplements work gradually at the cellular level, and cumulative benefits build over time.
Can I take grape seed extract with other supplements?
Grape seed extract pairs well with vitamin C, which enhances its antioxidant effects synergistically. It also combines effectively with CoQ10 for heart health, resveratrol for anti-aging support, and pine bark extract for comprehensive OPC coverage. However, avoid taking it simultaneously with iron supplements, as OPCs may reduce iron absorption—separate these by at least 2 hours.
Is grape seed extract safe for daily long-term use?
Studies lasting up to 12 months show grape seed extract is safe for extended use at recommended doses. The supplement has a long history of traditional use and extensive safety research. However, some practitioners recommend periodic breaks (such as one week off per month or cycling 3 months on, 1 month off) to maintain sensitivity to its effects and give your body variety.
What’s the difference between grape seed extract and grapefruit seed extract?
Despite similar names and often sharing the “GSE” abbreviation, these are completely different supplements with different uses. Grape seed extract comes from wine grape seeds and is rich in OPCs for antioxidant and cardiovascular support. Grapefruit seed extract (also called GSE or citricidal) comes from citrus grapefruit and is primarily used for antimicrobial purposes. Always check labels carefully to ensure you’re purchasing the correct product.
Can grape seed extract help with skin health?
Yes, many users take grape seed extract specifically for skin benefits. OPCs support collagen cross-linking, which helps maintain skin firmness and elasticity. The antioxidant properties also protect against UV-induced oxidative damage and environmental stressors. Some studies suggest grape seed extract may help improve skin moisture and reduce the appearance of age spots. Results are typically visible after 8-12 weeks of consistent use.
Does the source of grapes matter for grape seed extract quality?
Geography can influence quality, though standardization is more important than origin alone. French-grown grapes (like those used in Terry Naturally’s VX1 extract) have a strong reputation, and some European sources use traditional wine grape varieties with higher natural polyphenol content. However, a well-standardized extract from any reputable source will deliver consistent benefits—the standardization percentage (90-95% polyphenols) matters more than terroir.
Final Verdict
For most users seeking a reliable, high-quality grape seed extract, Zazzee Grape Seed 50:1 Extract offers the best combination of potency, quality, and value with its industry-leading 95% polyphenol standardization and generous 6-month supply. The concentrated formula delivers clinically-relevant doses in just one capsule daily.
If you’re budget-conscious but still want effective results, Nutricost Grape Seed Extract delivers impressive potency (28,000mg equivalent) at an unbeatable price point, with an 8-month supply making it the most economical long-term option.
For premium absorption and maximum bioavailability, Thorne Grape Seed Extract with patented phytosome technology is worth the investment, especially for athletes, those with digestive sensitivities, or anyone who hasn’t seen results from standard extracts. The clinical research backing this delivery system is compelling.
If purity and authenticity are your priorities, Terry Naturally Clinical OPC provides verified French grape seed extract with the highest OPC concentration available (≥80%), backed by independent testing proving it’s genuine grape seed—not adulterated material.
And for organic purists who want whole-food nutrition, Pure Synergy SuperPure provides certified organic grape seed with whole-fruit polyphenols from sustainable European vineyards.
Whatever your choice, prioritize products standardized to at least 90% polyphenols from reputable brands with transparent third-party testing. Grape seed extract is a well-researched supplement with genuine benefits for cardiovascular health, skin vitality, and antioxidant protection—but quality varies dramatically across the market. Investing in a quality product ensures you’re actually getting the OPCs your body needs to thrive.
