Best Inositol for Weight Loss (2026) – Top 10 Reviewed
Inositol, particularly the myo-inositol and D-chiro-inositol combination, has gained recognition as an effective supplement for weight loss, especially for women with PCOS and insulin resistance. This B-vitamin-like compound improves insulin sensitivity, regulates hormones, and supports metabolic health. This guide covers the best inositol supplements available on Amazon for effective weight management and hormone balance.
Our Top Picks at a Glance
- Best Overall: Myo-Inositol & D-Chiro Inositol Hormone Balance — ideal 40:1 ratio
- Best Powder: Myo-Inositol & D-Chiro Inositol Powder — flexible dosing
- Best Gummies: Pink Stork Premium Fertility Gummies — enjoyable format
Quick Comparison
| Product | Key Ingredients | Form | Servings | Best For |
|---|---|---|---|---|
| Myo & D-Chiro Inositol | 2000mg Myo, 50mg D-Chiro | Capsules | 120 | Hormone balance |
| Microburst Inositol | Myo & D-Chiro 40:1 Ratio | Capsules | 120 | PCOS support |
| Legendairy Milk Pure Inositol | Myo & D-Chiro Inositol | Powder | 60 | Flexible dosing |
| Fertility Inositol Blend | Myo, D-Chiro, Folate | Capsules | 120 | Fertility focus |
| Inositol with Choline | Myo, D-Chiro, Choline | Capsules | 120 | Metabolic support |
| Pink Stork Fertility Gummies | Inositol, CoQ10, Folate | Gummies | 60 | Great taste |
| Pink Stork Inositol + CoQ10 | Inositol, CoQ10 | Capsules | 60 | Energy support |
1. Myo-Inositol & D-Chiro Inositol for Hormone Balance — Best Overall
- WOMEN’S HORMONE BALANCE: Myo & D-Chiro Inositol is a premium women's hormone balance supplement with a blend of ingredients that work side-by-side to support women’s reproductive health and restore balance to the monthly cycle.*
- IDEAL 40:1 RATIO: Our inositol pills are formulated to match the body’s normal ratio of 40:1, with Myo Inositol 2000mg and D-Chiro Inositol 50mg powder per serving.
- OVARIAN SUPPORT VITAMINS & MENSTRUAL SUPPORT: By working together to support hormone balance, Myo Inositol and D Chiro Inositol encourage healthy ovulation and regular, more comfortable menstrual cycles.*
- MYO-INOSITOL & D-CHIRO INOSITOL: The benefits of a Myo and D-Chiro Inositol supplement extend beyond ovarian health supplements! By supporting your body’s healthy hormone rhythms, this formula can help with energy, bloating, skin health, and more.*
- 60-DAY SUPPLY: Myo D-Chiro Inositol by SMNutrition is Vegan, Hormone-Free, and formulated Gluten-Free and Non-GMO. It is Third-Party Tested, formulated without the top 9 allergens, and manufactured in a facility that is certified GMP compliant with NSF standards.
This premium formula provides the ideal 40:1 ratio of myo-inositol to D-chiro-inositol for optimal hormone balance and metabolic support.
Each serving delivers 2000mg myo-inositol and 50mg D-chiro-inositol, the exact ratio found naturally in the body and supported by clinical research. This combination improves insulin sensitivity, supports healthy ovulation, and helps regulate hormones. The formula is specifically designed for women with PCOS, insulin resistance, or hormone imbalances affecting weight.
What We Like
- Perfect 40:1 ratio matches clinical studies
- High-potency 2000mg myo-inositol dose
- Supports both hormone balance and metabolism
What Could Be Better
- Large capsule size due to high dose
- Requires 2-4 capsules daily for full dose
Bottom Line: The gold standard inositol formula with clinically-proven ratios for weight loss and hormone balance.
2. Microburst Myo & D-Chiro Inositol — Best for PCOS
- HORMONAL BALANCE FOR WOMEN: Myo & D-Chiro Inositol work side-by-side to support women’s reproductive health and restore balance to the monthly cycle. Our balanced blend of the two ingredients creates a premium women’s hormone balance supplement.*
- OVARIAN HEALTH & MENSTRUAL SUPPORT: By working together to support hormone balance, Myo Inositol and D Chiro Inositol encourage healthy ovulation and regular, more comfortable menstrual cycles.*
- FULL BODY BENEFITS: The benefits of a Myo and D-Chiro Inositol supplement extend beyond ovarian health! By supporting your body’s healthy hormone rhythms, this formula can help with energy, bloating, skin health, and more.*
- DELAYED RELEASE MICROBEADLETS: Microbeadlet encapsulation protects our Inositol formula from breakdown in the stomach, and improves absorption in the digestive tract, to deliver consistent support for hormone balance.*
- ONE-MONTH SUPPLY: Our Myo D-Chiro Inositol microbeadlets come in a one-month supply with 120 capsules. Each bottle is formulated Non-GMO, Third-Party Tested, and manufactured in a cGMP facility.
This microburst formula delivers inositol in small, frequent doses throughout the day for steady blood sugar support.
The microburst technology provides sustained inositol levels by dividing the daily dose across multiple capsules. This mimics how your body naturally metabolizes inositol, providing more stable blood sugar and hormone levels. The 40:1 myo to D-chiro ratio supports insulin sensitivity and ovulation in women with PCOS.
What We Like
- Microburst delivery for steady levels
- Ideal for PCOS and insulin resistance
- 120 servings for excellent value
What Could Be Better
- Requires multiple doses throughout day
- May need pill organizer for consistency
Bottom Line: An innovative delivery system that provides steady inositol levels for optimal PCOS and weight management.
3. Legendairy Milk Pure Inositol Powder — Best Powder
- 𝐎𝐏𝐓𝐈𝐌𝐀𝐋 𝟒𝟎:𝟏 𝐈𝐍𝐎𝐒𝐈𝐓𝐎𝐋 𝐑𝐀𝐓𝐈𝐎: Designed specifically to aid cycle support, ovarian function, and hormone balance for women, we've matched the body's IDEAL, and naturally occuring, ratio of 40:1 Myo & D-Chiro Inositol to support a healthy menstrual cycle and hormone levels.
- 𝐅𝐄𝐑𝐓𝐈𝐋𝐈𝐓𝐘 𝐒𝐔𝐏𝐏𝐋𝐄𝐌𝐄𝐍𝐓𝐒 𝐅𝐎𝐑 𝐖𝐎𝐌𝐄𝐍: Inositol has been shown to promote natural hormonal balance and fertility support for women. Some women with PCOS have reported that Myo and D-Chiro Inositol vitamins supported their metabolic and reproductive health. If you're trying to conceive, a pure Inositol blend is often suggested as a must-have natural supplement to support conception for women.
- 𝐍𝐀𝐓𝐔𝐑𝐀𝐋 𝐇𝐎𝐑𝐌𝐎𝐍𝐄 𝐒𝐔𝐏𝐏𝐎𝐑𝐓: Each 4-capsule dose of fun, purple capsules, contains the ideal ratio of active Myo Inositol powder compared to standard Inositol gummies. 120 purple capsules (30 day supply)
- 𝟑𝟎 𝐃𝐀𝐘 𝐒𝐔𝐏𝐏𝐋𝐘: Recommended 4 capsules per day - Ingredients: Myo Inositol 2000mg D Chiro Inositol 50mg - All our third-party tested Myo Inositol supplements are Made in the USA in a cGMP certified facility - Natural Ingredients - Vegan, Halal, Gluten-free, Dairy-free, and Sugar-free.
This pure inositol powder offers flexible dosing and easy mixing for customized supplementation.
The unflavored powder contains both myo-inositol and D-chiro-inositol in the research-backed 40:1 ratio. Mix into water, smoothies, or your favorite beverage for easy consumption. The powder format allows you to adjust doses based on your needs and makes it easier to take higher doses without multiple capsules.
What We Like
- Powder format allows flexible dosing
- Easy to mix into beverages
- No capsules to swallow
What Could Be Better
- Requires measuring for accurate dosing
- May have slight taste some find chalky
Bottom Line: The most flexible inositol option for those who prefer powders or need customized doses.
4. Fertility Inositol Blend with Folate — Best for Fertility
- WOMEN’S HORMONE BALANCE: This premium inositol supplement for women combines the two most potent forms of inositol (Vitamin B8), Myo & D-Chiro Inositol, to optimize hormonal balance and effectively support ovarian, menstrual, and reproductive health.*
- IDEAL 40:1 RATIO: Our Myoinositol and D Chiro Inositol pills are formulated to match the body’s own ratio of 40:1, with 2,000 mg of Myo-Inositol and 50 mg of D-Chiro Inositol powder per serving.
- FEMININE HEALTH SUPPLEMENT: Together, Mio Inositol D Chiro Inositol encourage healthy ovulation and regulate menstrual cycles, for overall ovarian function support.* Try these vitamins for women to promote happy hormones and peace of mind.*
- OVARIAN SUPPORT VITAMINS: By encouraging hormone balance for women fertility, Myo and D-Chiro Inositol are the preferred ovarian health supplements for promoting overall women’s balance, and for supporting your reproductive goals.*
- MYO-INOSITOL & D-CHIRO INOSITOL: Myo D-Chiro Inositol capsules by SMNutrition are Vegan, Hormone-Free, and formulated Gluten-Free, Non-GMO, and free of the top 9 allergens. Our Myo Inositol supplement is manufactured in a facility that is certified GMP compliant with NSF standards.
This comprehensive formula combines inositol with folate and additional nutrients for complete fertility and metabolic support.
Beyond the standard myo and D-chiro inositol blend, this formula adds folate for cellular health, vitamin D for hormone support, and other nutrients that support both fertility and weight management. The combination addresses the interconnected issues of PCOS, insulin resistance, and reproductive health.
What We Like
- Complete formula beyond just inositol
- Folate supports cellular health
- Addresses multiple PCOS symptoms
What Could Be Better
- More ingredients mean higher capsule count
- Premium pricing for comprehensive formula
Bottom Line: A complete approach to PCOS, fertility, and weight management in one comprehensive formula.
5. Inositol with Choline — Best for Metabolic Support
- Many Names Same Great Product - Inositol can go by names like myoinositol vitamin B8 or myo inositol, our product contains 2 forms of this specialized ingredient for health benefits
- Fertility Supplement for Women - Not all female fertility supplements can help achieve hormonal balance for women but this unique blend may help with fertility health and promote cycle balance
- Cycle Support - Anyone looking for a healthy cycle can benefit from our inositol and choline supplement that can also promote healthy and normal ovulation and even help assist in monthly mood support
- Clean Formula - Get the great benefits without the not so great additives with our potent vegan myo and D-chiro inositol and choline supplement made in the USA with globally sourced ingredients
- Natures Craft Quality - We are proud to be a leading name in female hormone balance supplements and prenatal vitamins for women because we believe in family values and want your family to grow
This unique formula adds choline to inositol for enhanced liver support and fat metabolism.
Choline complements inositol by supporting liver function and fat metabolism. The combination helps your body process fats more efficiently while the inositol improves insulin sensitivity. This dual-action approach supports weight loss through both improved glucose metabolism and enhanced fat processing.
What We Like
- Choline adds liver and metabolism support
- Addresses fat metabolism specifically
- Good value for combination formula
What Could Be Better
- Choline may cause fishy body odor in some
- Larger capsules due to added ingredient
Bottom Line: An enhanced inositol formula that adds metabolic benefits through choline supplementation.
6. Pink Stork Premium Fertility Gummies — Best Gummies
- Hormone Balance for Women: Trying to conceive shouldn’t feel like guesswork. Pink Stork Premium Fertility Gummies deliver daily support for your body’s natural reproductive rhythm — with 13 key ingredients recommended by OBGYNs and specialists.
- Expert-Backed Conception for Women: Support your menstrual cycle, ovarian health, hormonal health, egg quality, and luteal phase with two tasty gummies daily. Formulated with Myo-Inositol, CoQ10, and Methylated Folate (the natural, more bioavailable form of folic acid) to help support hormone balance, reproductive health, normal ovulation, cycle regularity, and energy, while CoQ10 and B-Vitamins fuel your cells for the energy your body needs on this journey. Delicious, nutrient-packed, and crafted to support your chances of conception. For best results, take for at least 3 months prior to conception.
- Hormone Harmony + Reproductive Wellness: Balanced hormones are the foundation of fertility. Our blend of vitamins and minerals supports natural hormone balance, ovulation rhythm, and healthy reproductive function. With Vitamin D, Zinc, Selenium, and B12, this clean formula nourishes your body from the inside out, so you can feel more in control of your fertility journey. No more chalky pills or complicated routines. These delicious, mango pineapple-flavored bite-sized gummies make it easy to enjoy fertility-focused nutrients in a convenient daily ritual—perfect for wherever life takes you.
- Clean, Vegan, and Delicious: No mystery ingredients or artificial extras here — just delicious mango pineapple gummies and clean, vegan-friendly nutrition. Third-party tested in GMP-certified facilities, our gummies meet the highest manufacturing standards. Free from GMOs, gluten, soy, and artificial colors and flavors, so you can enjoy them with confidence. Enjoy as part of your ritual with additional Pink Stork Fertility products - including our Fertility Tea (with Vitex and Red Raspberry Leaf) or Myo-Inositol & D-Chiro Inositol supplements. And don't forget Blue Stork Fertility Supplements for men! Once a positive pregnancy test occurs, change to a prenatal like Total Prenatal + DHA.
- Created by Women, For Women: We know the TTC journey isn’t always easy — but we are here to take the guesswork out of your nutrition. Formulated by women’s health experts, crafted with care, made in the USA, and third-party tested for purity, Pink Stork delivers support you can trust. Women-owned, women-run, and backed by experts— we’re here to walk with you every step of the way. As always, we recommend consulting your healthcare provider before using this product alongside medications or other supplements to ensure your personal needs are met. No refrigeration needed.
These delicious gummies make inositol supplementation enjoyable with added CoQ10 and folate for fertility support.
Each serving of these berry-flavored gummies provides inositol along with CoQ10 for cellular energy and folate for reproductive health. The pleasant taste makes daily supplementation something to look forward to rather than a chore. From the trusted Pink Stork brand known for women’s health products.
What We Like
- Great taste encourages daily compliance
- Includes CoQ10 and folate
- From trusted Pink Stork brand
What Could Be Better
- Contains added sugars for flavor
- Lower inositol dose than capsules
Bottom Line: An enjoyable way to supplement with inositol when capsules or powders aren’t appealing.
7. Pink Stork Inositol + CoQ10 Capsules — Best Energy Support
- Natural Fertility Support for Women (TTC): Pink Stork Fertility Support is thoughtfully formulated to help nourish your body’s natural fertility process and is more comprehensive than standalone inositol products, blending essential nutrients and supportive herbal ingredients in one 2-in-1 daily female fertility supplement + prenatal vitamin, so no need for a separate prenatal multivitamin. Designed to support hormone balance, reproductive wellness, ovarian health, and cycle regularity - because your journey to conception deserves gentle, consistent care from within. From a women-led brand that prioritizes clarity over hype. Take 2 capsules a day with or without food, 30 servings.
- Science-Backed Nutrients: Our formula includes Myo-Inositol powder and L-5-MTHF (methylated folate) - the active, bioavailable form of folate your body can use, unlike synthetic folic acid that must be converted first - two clinically studied nutrients that play key roles in supporting healthy ovulation, ovarian function, and reproductive health. Thoughtfully included to align with how many TTC shoppers build their plans, with simple directions for consistent use - helping empower you to feel informed and confident as you care for your fertility routine.
- Herbal Support for Cycle Regularity + Hormone Harmony: Features Vitex (Chasteberry), Organic Ashwagandha, Shatavari, and complementary botanicals often chosen during preconception to support healthy hormone balance and a predictable cycle. Our products are realistic - no guarantees, no timelines - just supportive ingredients you can understand and use daily. Clear label, straightforward routine, and easy to take wherever life takes you- at home or on the go - with room to personalize with your provider’s guidance.
- Nutrient-Rich Formula for Preconception Wellness: With CoQ10, iron, zinc, and B vitamins, this formula provides comprehensive nutritional support for reproductive health, along with vitamins important for preconception nutrition. These ingredients help nourish egg quality, support cellular energy, and contribute to hormone regulation - key elements for women TTC. As with any products designed to support hormonal health, Fertility Support may impact your cycle. For best results, we recommend consistent use for at least 3 months; discontinue use once you receive a positive pregnancy test and transition to a prenatal vitamin. Pair with Pink Stork's Fertility Tea and Wild Yam Cream.
- Women-Owned: Pink Stork is women-owned and women-run, founded by a Certified Health Coach committed to clear language and thoughtful formulas. Every bottle is produced with rigorous quality standards and transparent labeling that you can read at a glance. Add it to your TTC routine to support ovulation, cycle balance, and everyday reproductive wellness. Our goal: make the “what should I take?” question feel manageable, with a formula you can stick with over time. Our Fertility Support capsules are vegan, non-GMO, and made without gluten, soy, or artificial ingredients. Third-party tested for purity, UV-protected bottle, crafted with care, & guided by science.
This formula combines inositol with CoQ10 for dual support of metabolic health and cellular energy.
CoQ10 enhances the metabolic benefits of inositol by supporting mitochondrial function and energy production. This combination helps combat the fatigue often associated with PCOS and insulin resistance while supporting weight loss efforts. The capsule format provides higher doses than gummies.
What We Like
- CoQ10 supports cellular energy
- Addresses PCOS-related fatigue
- Higher doses than gummy format
What Could Be Better
- CoQ10 adds to cost
- May take 4-6 weeks to notice energy benefits
Bottom Line: A smart combination that addresses both metabolic health and the energy issues common with insulin resistance.
How to Choose the Best Inositol for Weight Loss
Start by identifying whether you have PCOS or insulin resistance, as these conditions respond particularly well to inositol supplementation. If you have PCOS, prioritize formulas with the 40:1 myo-inositol to D-chiro-inositol ratio, which research shows is most effective for improving insulin sensitivity and promoting ovulation. This ratio also supports weight loss in women with hormone imbalances.
Consider the delivery format that fits your lifestyle. Capsules provide standardized doses and are convenient for travel. Powders offer flexibility in dosing and are easier for those who dislike swallowing pills, plus they allow you to start with lower doses and gradually increase. Gummies taste better and encourage compliance but contain added sugars and lower doses.
Evaluate additional ingredients that may benefit your specific situation. If you’re trying to conceive, look for formulas with folate and vitamin D. For metabolic support, choline aids liver function and fat metabolism. CoQ10 helps with cellular energy, which can combat PCOS-related fatigue. B-vitamins support energy and hormone metabolism.
Check the dosage and serving size to ensure you’re getting clinically-effective amounts. Research typically uses 2000-4000mg myo-inositol daily, with most benefits seen at 2000mg. The D-chiro-inositol dose should be around 50mg to maintain the 40:1 ratio. Some products require multiple capsules to reach therapeutic doses.
Look for quality indicators including third-party testing, GMP certification, and clear labeling of both types of inositol and their exact amounts. Avoid proprietary blends that don’t specify the ratio or amounts. Quality matters because inositol’s effectiveness depends on getting the right ratio and dose.
Benefits of Inositol for Weight Loss
Inositol significantly improves insulin sensitivity, which is crucial for weight loss, especially in women with PCOS. By helping cells respond better to insulin, inositol reduces circulating insulin levels. High insulin promotes fat storage, particularly around the abdomen, so lowering insulin creates a more favorable environment for fat burning. Studies show inositol can reduce insulin resistance by 75% in women with PCOS.
Hormone balance improves with inositol supplementation, which indirectly supports weight management. Inositol helps regulate menstrual cycles, reduce androgen levels, and improve ovulation in women with PCOS. These hormone improvements reduce symptoms like acne and excess hair growth while making it easier to lose weight. Balanced hormones also reduce stress-related eating and cravings.
Appetite regulation occurs through multiple mechanisms. Inositol improves leptin sensitivity, helping your brain recognize satiety signals more effectively. It also stabilizes blood sugar, reducing the energy crashes that trigger cravings. Many women report reduced sugar cravings and better appetite control within 4-6 weeks of starting inositol.
Metabolic improvements extend beyond just insulin and hormones. Inositol supports healthy cholesterol levels, reduces inflammation, and may improve liver function. These broader metabolic benefits create a healthier internal environment that supports sustainable weight loss. Research shows women with PCOS who take inositol lose an average of 5-7% of body weight over 6 months.
Frequently Asked Questions
How much inositol should I take for weight loss?
The most effective dose is 2000mg myo-inositol combined with 50mg D-chiro-inositol (40:1 ratio) taken twice daily, for a total of 4000mg myo-inositol daily. However, many women see benefits with 2000mg daily. Start with a lower dose (1000-2000mg) and gradually increase based on tolerance and results.
How long does it take for inositol to work for weight loss?
Most women notice improved energy and reduced cravings within 2-4 weeks. Measurable weight loss typically appears after 8-12 weeks of consistent use. Hormone improvements like regular cycles may take 2-3 months. Insulin sensitivity improvements can show in blood work after just 6-8 weeks.
Is inositol only for women with PCOS?
While inositol is particularly effective for PCOS, anyone with insulin resistance can benefit for weight loss. Men with metabolic syndrome have shown improvements in insulin sensitivity with inositol. However, the research is strongest for women with PCOS, and the hormonal benefits are specific to women.
Can I take inositol with metformin?
Yes, inositol and metformin can be taken together and may have synergistic effects for PCOS and insulin resistance. However, monitor your blood sugar carefully as the combination may lower it more than either alone. Always inform your doctor before combining them so they can adjust your metformin dose if needed.
What’s the difference between myo-inositol and D-chiro-inositol?
Myo-inositol is more abundant in the body and primarily improves insulin sensitivity and hormone production. D-chiro-inositol works more on glucose storage and utilization. Your body naturally converts myo to D-chiro at about a 40:1 ratio, which is why supplements should match this ratio for optimal results.
Should I take inositol with food or on an empty stomach?
Inositol can be taken with or without food, but taking it with meals may reduce any mild stomach upset. Dividing your dose into twice daily (morning and evening) provides more stable blood levels than one large dose. Some women prefer taking it with breakfast and dinner.
Are there any side effects of inositol?
Inositol is generally very well tolerated. Some women experience mild nausea, stomach upset, or headaches when first starting, but these typically resolve within a week. Very high doses (over 12g daily) may cause diarrhea. Side effects are rare and much less common than with prescription diabetes medications.
Will I gain weight back if I stop taking inositol?
If inositol helped you lose weight by improving insulin sensitivity and you maintain healthy lifestyle habits, you may keep the weight off. However, if insulin resistance returns without inositol, weight regain is possible. Many women choose to continue inositol long-term for ongoing metabolic and hormone support.
