Best Leaky Gut Support Supplements (2026) – Top 10 Reviewed
Leaky gut syndrome occurs when the tight junctions in your intestinal lining become compromised, allowing undigested food particles, toxins, and bacteria to pass into your bloodstream. The right supplements can help restore gut barrier integrity, reduce inflammation, and support healthy intestinal function.
The most effective leaky gut formulas combine ingredients like L-glutamine, colostrum, zinc carnosine, and soothing herbs that nourish and protect the gut lining. Here are our top 10 picks for 2026.
| Product | Key Ingredients | Servings | Form | Best For |
|---|---|---|---|---|
| Synbiotic 3-in-1 Prebiotics, Probiotics & Postbiotics | 50 Billion CFU, Prebiotics, Postbiotics | 30 | Capsules | Best Overall |
| Organic Bovine Colostrum Powder | Colostrum, Immunoglobulins | 73 | Powder | Best for Gut Barrier Repair |
| Advanced Acacia Fiber Leaky Gut Repair Powder | Organic Acacia Fiber | 30 | Powder | Best Value |
| Grass-Fed Bone Broth Protein Powder | Collagen, Glucosamine, Gelatin | 28 | Powder | Best Collagen-Based |
| DGL Licorice Gut Lining Support | DGL Licorice Root Extract | 280 | Powder | Best for Stomach Lining |
| Zazzee Organic Marshmallow Root | 10:1 Marshmallow Root Extract | 120 | Capsules | Best Herbal Option |
| USDA Organic Slippery Elm | Micronized Slippery Elm Bark | 60 | Capsules | Best for Mucilage Support |
| Zinc Carnosine Complex 3X | Zinc Carnosine, Bisglycinate, Copper | 120 | Capsules | Best Zinc Formula |
| HUJ L-Glutamine Nutrition Pack | 5000mg L-Glutamine, Fiber | 60 | Packets | Best L-Glutamine |
| Zinc L-Carnosine 11-in-1 Complex | Zinc Carnosine, L-Glutamine, Mastic Gum | 100 | Capsules | Best Comprehensive Formula |
1. Synbiotic 3-in-1 Prebiotics, Probiotics & Postbiotics – Best Overall
Why it stands out: This all-in-one formula delivers prebiotics, probiotics, and postbiotics in a single capsule, addressing multiple aspects of gut health simultaneously. The 50 billion CFU potency provides substantial microbial support for restoring gut barrier function.
The synbiotic approach combines live beneficial bacteria with the fuel they need (prebiotics) and the beneficial compounds they produce (postbiotics). This triple-action mechanism supports microbiome balance, which is essential for maintaining tight junctions in the intestinal lining. Research shows that a healthy microbiome produces short-chain fatty acids like butyrate that directly nourish intestinal cells and reduce inflammation.
What sets this formula apart is the inclusion of postbiotics—the metabolic byproducts of probiotic bacteria that provide benefits even without live organisms. Postbiotics include compounds like bacteriocins, enzymes, and organic acids that support gut barrier function and have anti-inflammatory properties. The 60-capsule bottle provides a full month’s supply when taking two capsules daily, and the vegan formula is suitable for most dietary preferences. The shelf-stable formulation means no refrigeration is required, making it travel-friendly.
Pros:
- Triple-action prebiotic, probiotic, and postbiotic formula
- High potency 50 billion CFU per serving
- Supports bloating relief and immune function
- Shelf-stable, no refrigeration needed
Cons:
- Premium price point for multi-action formula
Best for: Anyone seeking a comprehensive gut health solution that addresses microbiome balance, gut barrier support, and digestive comfort in one supplement.
2. Organic Bovine Colostrum Powder – Best for Gut Barrier Repair
Why it stands out: Colostrum is nature’s first food, packed with immunoglobulins, growth factors, and lactoferrin that directly support intestinal lining repair. This organic, grass-fed formula delivers concentrated gut-healing compounds in an easy-to-mix powder.
Bovine colostrum contains immunoglobulin G (IgG), which helps neutralize harmful pathogens in the gut while growth factors like IGF-1 and TGF-beta support tissue repair and cell regeneration. Studies indicate colostrum can help reduce intestinal permeability and support the regeneration of intestinal epithelial cells. The lactoferrin component provides antimicrobial properties and helps regulate iron absorption in the gut.
This organic, grass-fed colostrum is sourced from cows within the first 24 hours after calving, when immunoglobulin concentrations are highest. The unflavored powder mixes easily into smoothies, coffee, or water without altering the taste of your beverage. At 73 servings per container, this offers excellent value for a premium ingredient. Many users report improvements in digestive comfort and reduced food sensitivities within the first few weeks of consistent use.
Pros:
- Rich in immunoglobulins for immune support
- Contains growth factors for tissue repair
- Organic, grass-fed sourcing
- Generous 73-serving supply
Cons:
- Not suitable for those with dairy sensitivities
Best for: Individuals focused on rebuilding gut barrier integrity and supporting intestinal immune function.
3. Advanced Acacia Fiber Leaky Gut Repair Powder – Best Value
Why it stands out: This organic acacia fiber powder is specifically marketed for leaky gut repair, providing gentle prebiotic support that feeds beneficial bacteria without causing the bloating common with other fiber supplements. The affordable price makes it accessible for long-term use.
Acacia fiber is a soluble fiber that ferments slowly in the gut, producing less gas than rapidly fermenting fibers like inulin. This makes it ideal for those with sensitive digestive systems who struggle with prebiotic supplements. As a prebiotic, it selectively feeds beneficial Bifidobacteria and Lactobacillus species, promoting short-chain fatty acid production that nourishes the gut lining.
The slow fermentation profile means acacia fiber travels further into the colon before being metabolized, providing benefits throughout more of the intestinal tract. This is particularly beneficial for those with lower GI issues. The USDA organic certification ensures clean sourcing without pesticides or chemical processing. The 16oz container provides approximately 30 servings at an affordable price point, making it an excellent entry point for gut health support. The neutral taste mixes easily into water, smoothies, or even baked goods without detection.
Pros:
- Gentle on sensitive stomachs
- USDA organic certified
- Excellent price per serving
- Supports regularity without harsh effects
Cons:
- Single-ingredient formula requires additional supplements for comprehensive support
Best for: Budget-conscious consumers seeking gentle prebiotic support for gut health and regularity.
4. Grass-Fed Bone Broth Protein Powder – Best Collagen-Based
Why it stands out: Bone broth has been used for centuries as a gut-healing food in traditional cultures. This concentrated powder delivers the collagen, gelatin, glucosamine, and amino acids found in traditional bone broth in a convenient, shelf-stable form without hours of simmering.
The collagen and gelatin in bone broth provide the building blocks for intestinal tissue repair. When gelatin comes into contact with liquid, it forms a gel-like substance that soothes and protects the gut lining—similar to how it works in cooking. Glycine and proline—amino acids abundant in bone broth—support the production of mucus that protects the gut lining and helps form the collagen matrix that gives intestinal tissue its structure.
Glucosamine, naturally present in bone broth, may help repair and maintain the mucus layer of the intestines. This unflavored, 32oz powder is sourced from grass-fed beef bones, ensuring a clean amino acid profile without added hormones or antibiotics. The paleo and keto-friendly profile makes it suitable for various dietary approaches. Mix it into soups, smoothies, or simply with hot water for a warming, gut-supportive beverage. The neutral taste means it won’t alter the flavor of savory dishes, making it a versatile addition to your cooking routine.
Pros:
- Provides collagen types I, II, and III
- Contains glucosamine for mucus layer support
- Grass-fed, non-GMO sourcing
- Dairy-free and paleo-friendly
Cons:
- Large container may be inconvenient for travel
Best for: Those who prefer whole-food-based supplements and want collagen support for gut lining repair.
5. DGL Licorice Gut Lining Support – Best for Stomach Lining
Why it stands out: Deglycyrrhizinated licorice (DGL) has been used for over 3,000 years to soothe digestive complaints. This powder form provides an impressive 280 servings, making it one of the most economical options for long-term gut support.
DGL works by stimulating the production of mucin, the protective mucus that coats the stomach and intestinal lining. This mucus layer is your gut’s first line of defense against acid, enzymes, and irritating substances. Unlike regular licorice, DGL has the glycyrrhizin removed, eliminating concerns about blood pressure elevation or potassium depletion with long-term use.
Research suggests DGL can help maintain the integrity of the gut mucosal barrier and may be particularly beneficial for those dealing with H. pylori-related gut issues or acid-related digestive discomfort. The compound appears to increase blood flow to the stomach lining, promoting tissue repair and healing. The powder form allows flexible dosing—you can start with a smaller amount and adjust based on your response. Many practitioners recommend taking DGL about 20 minutes before meals to create a protective coating before food arrives. The 280-serving supply means this single container can last nearly a year with daily use, delivering exceptional value.
Pros:
- Exceptional value at 280 servings
- Supports natural mucus production
- Safe for long-term use (glycyrrhizin-free)
- Versatile powder form
Cons:
- Distinctive licorice taste may not appeal to everyone
Best for: Individuals seeking stomach lining protection and those who prefer economical, long-lasting supplements.
6. Zazzee USDA Organic Marshmallow Root – Best Herbal Option
Why it stands out: Marshmallow root is a traditional demulcent herb that forms a soothing, protective coating on mucous membranes throughout the digestive tract. This 10:1 concentrated extract delivers the equivalent of 3,000mg of marshmallow root per capsule for maximum potency.
The mucilage content in marshmallow root creates a gel-like substance when mixed with water that coats and protects irritated gut tissue. This protective barrier allows the intestinal lining to heal while shielding it from further damage from digestive acids, enzymes, and food particles. The coating action extends from the esophagus through the stomach and into the intestines, making marshmallow root beneficial for various digestive complaints.
The 10:1 extract concentration means you get the benefits of a much larger amount of the raw herb in a convenient capsule form—equivalent to 3,000mg of marshmallow root per serving. This concentrated approach ensures you’re getting therapeutic amounts without having to take multiple pills. USDA organic certification ensures clean sourcing without pesticides or chemical extraction methods. The 4-month supply in each bottle offers excellent value for a premium herbal supplement, and the capsule form is more palatable than the somewhat slimy texture of marshmallow root tea.
Pros:
- Potent 10:1 concentrated extract
- USDA organic certified
- 4-month supply per bottle
- Gentle, well-tolerated herb
Cons:
- May need to be taken with food for best results
Best for: Those seeking traditional herbal support for soothing and protecting inflamed gut tissue.
7. USDA Organic Slippery Elm – Best for Mucilage Support
Why it stands out: Slippery elm bark has been used by Native Americans for centuries to soothe digestive complaints and heal wounds. The micronized powder in these capsules ensures optimal absorption of the gut-protective mucilage compounds that give this herb its name.
When slippery elm comes into contact with water, it forms a slick gel that coats the digestive tract from throat to intestines. This mucilage stimulates nerve endings in the gastrointestinal tract, increasing natural mucus secretion and providing a physical barrier against acid, enzymes, and irritating food particles. The coating action is almost immediate, which is why slippery elm has traditionally been used for acute digestive discomfort.
The USDA organic certification ensures you’re getting pure slippery elm without pesticide residues or chemical processing. This herb is particularly beneficial for those experiencing both upper GI discomfort (like heartburn or esophageal irritation) and intestinal issues, as it provides continuous protection throughout the entire digestive tract. The micronized form breaks down more readily than standard slippery elm powder, enhancing the release of beneficial mucilage. As a bonus, slippery elm also soothes the throat and airways, making it a useful supplement during respiratory challenges.
Pros:
- Micronized for enhanced absorption
- USDA organic certified
- Soothes entire digestive tract
- Supports throat and airway comfort as a bonus
Cons:
- May interfere with absorption of medications if taken simultaneously
Best for: Individuals seeking natural mucilage support for comprehensive digestive tract soothing.
8. Zinc Carnosine Complex 3X – Best Zinc Formula
Why it stands out: Zinc carnosine is a specific form of zinc that concentrates in the stomach and intestinal lining rather than being rapidly absorbed into the bloodstream. This formula combines three forms of zinc with copper for balanced mineral support and long-term safety.
Zinc carnosine (also known as polaprezinc) has been extensively studied for gut health in both human and animal trials. Unlike other zinc forms that are quickly absorbed into the bloodstream, zinc carnosine adheres to the gastric mucosa, delivering zinc directly where it’s needed for tissue repair. Clinical research shows it can help maintain stomach lining integrity, support healthy intestinal permeability, and may help balance H. pylori levels.
This formula takes a comprehensive approach by including three forms of zinc: zinc carnosine for gut-specific support, zinc bisglycinate chelate for enhanced absorption, and zinc orotate for cellular delivery. The addition of chelated copper prevents the copper depletion that can occur with long-term zinc supplementation—an important consideration for anyone planning to take zinc daily. The formula also includes vitamin C, which supports immune function and collagen synthesis for tissue repair. The 120-capsule bottle provides a 4-month supply, and the gentle formulation is designed to be easy on sensitive stomachs.
Pros:
- Three forms of zinc for comprehensive support
- Includes copper to prevent mineral imbalance
- Easy on the stomach
- 4-month supply per bottle
Cons:
- Contains multiple ingredients beyond zinc carnosine
Best for: Those specifically seeking zinc support for stomach and intestinal lining repair.
9. HUJ L-Glutamine Nutrition Pack – Best L-Glutamine
Why it stands out: L-glutamine is the most abundant amino acid in the body and serves as the primary fuel source for intestinal cells. These convenient single-serving packets deliver a clinically relevant 5,000mg dose with added fiber for comprehensive gut support.
The cells lining your intestines—called enterocytes—use glutamine at a higher rate than any other cells in your body. They depend on this amino acid for energy production, protein synthesis, and maintaining the structural integrity of the gut barrier. During times of stress, illness, intense exercise, or gut inflammation, glutamine needs increase dramatically, and your body may not be able to produce enough to meet demand.
Supplementing with L-glutamine supports the regeneration of intestinal epithelial cells and helps maintain tight junction integrity—the connections between cells that prevent unwanted substances from passing through the gut barrier. The 5,000mg dose in each packet aligns with research-supported amounts for gut health benefits. The added polydextrose and oat fiber provide prebiotic support, feeding beneficial bacteria while the glutamine repairs the gut lining. Individual packets are perfect for travel or maintaining consistent dosing, and the powder dissolves easily in water or can be added to smoothies. Many athletes also appreciate glutamine’s muscle recovery benefits.
Pros:
- Research-backed 5,000mg dose
- Convenient single-serving packets
- Includes prebiotic fiber
- Supports muscle recovery as a bonus
Cons:
- Individual packets create more waste than bulk powder
Best for: Anyone seeking targeted L-glutamine supplementation for intestinal cell repair and gut barrier support.
10. Zinc L-Carnosine 11-in-1 Complex – Best Comprehensive Formula
Why it stands out: This all-in-one formula combines zinc carnosine with L-glutamine, mastic gum, and a soothing herbal blend, addressing multiple aspects of leaky gut in a single supplement for those who prefer simplicity over multiple bottles.
The 85mg zinc L-carnosine provides targeted support for stomach and intestinal lining repair, while L-glutamine fuels intestinal cell regeneration—combining two of the most research-supported ingredients for gut barrier health. Mastic gum, a resin from the Mediterranean mastic tree, has been used traditionally for digestive health for thousands of years and may help balance H. pylori levels while soothing gastric inflammation.
The herbal blend includes additional gut-soothing compounds that complement the primary ingredients. This comprehensive approach means fewer bottles on your shelf while still addressing the major pillars of leaky gut support: tissue repair with zinc carnosine, cellular regeneration with glutamine, microbial balance with mastic gum, and inflammation reduction with supportive herbs. The 100-capsule bottle provides over a month’s supply at the recommended dosage. The vegan, non-GMO formula is suitable for most dietary preferences. While individual ingredient doses are lower than in single-ingredient supplements, the synergistic combination may provide broader support for those with multiple gut health concerns.
Pros:
- Combines multiple gut-healing ingredients
- Includes zinc carnosine and L-glutamine
- Features mastic gum for H. pylori balance
- Vegan and non-GMO
Cons:
- Lower individual ingredient doses compared to single-ingredient supplements
Best for: Those seeking a convenient all-in-one formula that addresses multiple aspects of gut health.
What is Leaky Gut and Who Should Take These Supplements?
Leaky gut syndrome, technically called increased intestinal permeability, occurs when the tight junctions between intestinal cells become loose or damaged, allowing larger molecules to pass through the gut barrier into the bloodstream. Normally, these tight junctions act like bouncers at a club, only letting properly digested nutrients through while keeping out bacteria, toxins, and undigested food particles.
When this barrier becomes compromised, substances that should stay in the digestive tract can escape into circulation. The immune system recognizes these as foreign invaders and mounts an inflammatory response. Over time, this chronic low-grade inflammation can manifest as a wide range of symptoms including bloating, gas, food sensitivities, fatigue, joint pain, skin issues like eczema or acne, headaches, and brain fog.
Factors that can contribute to leaky gut include chronic stress, excessive alcohol consumption, overuse of NSAIDs like ibuprofen, antibiotics that disrupt the microbiome, processed foods, refined sugars, and infections. Some individuals may have a genetic predisposition to increased intestinal permeability as well.
Those who may benefit most from leaky gut supplements include individuals with chronic digestive complaints that don’t respond to conventional treatment, autoimmune conditions (which often have a gut component), multiple food intolerances that seem to be increasing, skin problems like eczema, acne, or rosacea, chronic fatigue, joint pain without clear cause, or those who have taken multiple rounds of antibiotics, long-term NSAIDs, or have experienced significant prolonged stress.
How to Choose the Right Leaky Gut Supplement
Key Ingredients to Look For
The most research-supported ingredients for leaky gut include L-glutamine (3-5g daily for gut lining repair), zinc carnosine (75-150mg for stomach and intestinal support), colostrum (for immunoglobulins and growth factors), and probiotics (particularly Lactobacillus and Bifidobacterium strains for microbiome balance). Demulcent herbs like slippery elm, marshmallow root, and DGL licorice provide soothing mucilage that protects irritated tissue while healing occurs.
Other beneficial ingredients include butyrate (a short-chain fatty acid that directly nourishes colon cells), vitamin D (which supports tight junction integrity), and omega-3 fatty acids (for reducing gut inflammation). Prebiotics like acacia fiber and inulin feed beneficial bacteria, promoting the production of healing compounds in the gut.
Single Ingredient vs. Combination Formulas
Single-ingredient supplements allow for precise dosing and work well for those who want to target specific aspects of gut health or who need higher doses than combination formulas provide. They also make it easier to identify which ingredients are helping versus causing reactions. Combination formulas offer convenience but may contain lower doses of individual ingredients. Consider starting with a core ingredient like L-glutamine or colostrum to establish a baseline, then adding additional support like zinc carnosine or probiotics based on your specific symptoms and response.
What to Avoid
Steer clear of formulas with artificial colors, flavors, or preservatives that may irritate a compromised gut—if you’re trying to heal your gut, adding synthetic chemicals makes little sense. Proprietary blends that hide ingredient amounts make it impossible to know if you’re getting effective doses of the active ingredients. Avoid supplements with common allergens like gluten, dairy, or soy if you have sensitivities, as these can worsen gut inflammation and counteract the benefits of the supplement. Also be wary of formulas with long lists of ingredients at low doses—these “kitchen sink” products often don’t provide therapeutic amounts of anything.
Side Effects and Precautions
Most leaky gut supplements are well-tolerated when taken as directed, but starting any new supplement regimen warrants attention to your body’s responses. L-glutamine may cause mild digestive upset, headaches, or dizziness in some individuals when starting—begin with a lower dose (2g instead of 5g) and increase gradually over a week or two. Some people report that high doses of glutamine cause excitatory effects; if you’re sensitive to MSG, you may be more likely to experience this.
Zinc supplementation should include copper to prevent deficiency with long-term use—taking zinc for extended periods without copper can lead to anemia and neurological problems. The zinc carnosine form is generally well-tolerated, but nausea can occur if taken on an empty stomach. DGL licorice is safe for most people, but those with high blood pressure should confirm the glycyrrhizin has been completely removed. Slippery elm and marshmallow root may slow the absorption of medications taken at the same time—space them at least two hours apart from prescription drugs.
Pregnant or breastfeeding women should consult their healthcare provider before starting any new supplement, as limited safety data exists for many gut health ingredients during pregnancy. Those taking prescription medications, particularly immunosuppressants, blood thinners, or diabetes medications, should check for interactions. If you have a diagnosed autoimmune condition, work with a healthcare practitioner who understands the gut-immune connection to create an appropriate protocol—healing the gut too quickly can sometimes trigger immune flares.
FAQs
How long does it take to heal leaky gut with supplements?
Most practitioners suggest a 3-6 month timeline for meaningful gut healing, though some people notice improvements in digestive symptoms within 2-4 weeks. Consistency is key—taking supplements sporadically won’t produce results. Combining supplementation with dietary changes like removing inflammatory foods accelerates progress.
Can I take multiple leaky gut supplements together?
Yes, many supplements work synergistically. A common protocol combines L-glutamine for cellular repair, a probiotic for microbiome balance, and a soothing herb like slippery elm or DGL. Start with one supplement to assess tolerance, then add others gradually. Taking too many at once can make it difficult to identify what’s working.
Should I take leaky gut supplements with food or on an empty stomach?
L-glutamine is often recommended on an empty stomach for optimal absorption. Probiotics can be taken with or without food, though some strains survive better with a meal. Demulcent herbs like slippery elm and marshmallow root work best when taken 30 minutes before meals to coat the digestive tract. Zinc carnosine can be taken with food to minimize any stomach upset.
What diet changes support leaky gut healing?
Remove inflammatory foods like gluten, refined sugar, processed foods, and alcohol. Add gut-healing foods like bone broth, fermented vegetables, omega-3-rich fish, and colorful vegetables. Some people benefit from an elimination diet to identify personal food triggers. Eating in a relaxed state and chewing thoroughly also supports digestive function.
Are there any tests for leaky gut?
The lactulose-mannitol test measures intestinal permeability by tracking how these two sugars are absorbed and excreted. Zonulin levels in blood or stool can indicate tight junction dysfunction. However, many functional medicine practitioners diagnose leaky gut based on symptom presentation and response to treatment rather than formal testing.
Can probiotics alone heal leaky gut?
Probiotics support gut healing by improving microbiome balance and producing beneficial compounds like butyrate, but they work best as part of a comprehensive approach. Combining probiotics with gut-lining-specific nutrients like L-glutamine and colostrum, along with dietary changes, provides more complete support for intestinal barrier repair.
Final Verdict
For comprehensive leaky gut support, we recommend the Synbiotic 3-in-1 Prebiotics, Probiotics & Postbiotics as the best overall choice. Its triple-action formula addresses microbiome balance, produces gut-healing postbiotics, and supports digestive comfort in one convenient supplement.
For those focused specifically on gut barrier repair, Organic Bovine Colostrum Powder delivers concentrated immunoglobulins and growth factors that directly support intestinal tissue healing. Budget-conscious consumers will find excellent value in the Advanced Acacia Fiber Leaky Gut Repair Powder, which provides gentle prebiotic support at an affordable price point.
Those seeking a comprehensive single-capsule solution should consider the Zinc L-Carnosine 11-in-1 Complex, which combines multiple gut-healing ingredients including zinc carnosine, L-glutamine, and mastic gum. Remember that healing leaky gut typically requires a multi-pronged approach combining supplementation with dietary changes and stress management for optimal results.
