Best Methylated Vitamins
Methylated vitamins provide nutrients in their bioactive, pre-converted forms that your body can use immediately without additional metabolic processing. This is especially important for the estimated 40-60% of people with MTHFR gene variations who struggle to convert synthetic folic acid and standard B vitamins into usable forms. If you experience persistent fatigue, brain fog, or have tested positive for MTHFR mutations, methylated vitamin formulas can help you achieve optimal nutrient levels and cellular function.
Our Top Picks at a Glance
- Best Overall: Micro Ingredients Pure Methylated Multivitamin – comprehensive 19-in-1 formula
- Best for MTHFR: Double Wood Methylated Multivitamin – contains only activated forms
- Best Value: Eliixr Methylated Multivitamin – 27 nutrients in single capsule
Quick Comparison
| Product | Key Forms | Nutrients | Servings | Best For |
|---|---|---|---|---|
| Micro Ingredients Methylated | Methylfolate, Methylcobalamin, P5P | 19 | 120 | Overall methylation |
| Double Wood Methylated | All active forms + TMG | 6 | 120 | MTHFR support |
| Eliixr 27-in-1 | 1500mcg Methylfolate, CoQ10 | 27 | 60 | Once-daily convenience |
| Igennus Men’s Methylated | Slow-release methylated Bs | 22 | 60 | All-day coverage |
| NatureGenX Just One Daily | Quatrefolic, CoQ10, ALA | 27 | 60 | Iron-free formula |
| Igennus Women’s High Potency | Sustained-release methylated | 23 | 180 | Women’s wellness |
| 10X Health Optimize | 5-MTHF, Active B-complex | 34 | 90 | Comprehensive formula |
1. Micro Ingredients Pure Methylated Multivitamin – Best Overall
- Micro Ingredients offers a Pure Methylated Multivitamin Complex. 19-in-1 support with high absorption bioactive forms. 240 capsules that feature raw, active ingredients with no fillers.
- Each serving provides active methylated vitamins like fat-soluble vitamin C (ascorbyl palmitate), A (retinyl palmitate), D3 (cholecalciferol), E (d- alpha tocopherol), thiamin HCl, riboflavin (R5P), niacin (niacinamide), B6 (P5P), folate, B12 (methylcobalamin), biotin, and pantothenic acid.
- An advanced multivitamin combined with key minerals for promoting various health benefits.
- Enjoy only active ingredients that use high bioavailable methylated vitamins and minerals for efficiently refilling key nutritional gaps over time.
- Premium non-GMO multivitamins supplement. Made without fillers, soy, dairy, wheat, gluten, fish, shellfish, peanuts, and tree nuts. Ingredients must pass our 3rd party lab tests to ensure a product that is safe, pure, and potent.
Micro Ingredients delivers exceptional value with a filler-free methylated formula providing 19 active nutrients in their most bioavailable forms.
This comprehensive formula features fat-soluble vitamin C as ascorbyl palmitate, vitamin A as retinyl palmitate, D3 as cholecalciferol, E as d-alpha tocopherol, plus complete methylated B-complex including riboflavin R5P, niacin as niacinamide, B6 as P5P, methylfolate, and B12 as methylcobalamin. The 240-capsule bottle provides 120 servings of two capsules each, with key minerals including magnesium and zinc for comprehensive nutritional support.
What We Like
- No fillers, soy, dairy, gluten, or allergens
- Third-party lab tested for purity and potency
- High bioavailable methylated forms throughout
- Excellent value at 120 servings
- Non-GMO and clean label
What Could Be Better
- Requires two capsules per serving
- Strong natural odor from active ingredients
Bottom Line: If you want a comprehensive methylated multivitamin without unnecessary fillers at an exceptional price point, Micro Ingredients provides premium quality backed by independent testing.
2. Double Wood Methylated Multivitamin – Best for MTHFR
- METHYLATED FORMS OF VITAMINS: Double Wood's Methylated Multivitamin contains only methylated / activated forms of vitamins that are already usable by the body and do not need to be further converted in order to be bioavailable
- METHYLATED B COMPLEX: Contains the Methylated / Activated Coenzyme form of Vitamin B2 (R-5-P), Vitamin B6 (P-5P) and Vitamin B12 (Methylcobalamin and Dibencozide)(Methyl B12)
- SIX TOTAL METHYLATED VITAMINS: Contains trimethylglycine and calcium L-5-methyltetrahydrofolate (MTHFR multivitamin) to help support healthy folic acid levels and control homocysteine levels in the body. It is important to use methylated folic acid since standard folic acid is inert in the body and cannot be processed further by many people
- CAN COMBINE WITH A NORMAL MULTIVITAMIN: Double Wood's Methylated Multivitamin can be combined with a regular multivitamin for those looking to also supplement with inactive vitamins or vitamins such as Magnesium and Vitamin D
- WE BOTTLE WELLNESS: At Double Wood we provide pure, potent supplements that deliver exceptional value, all backed by careful sourcing and rigorous third-party testing
Double Wood’s focused formula contains only methylated and activated vitamin forms specifically designed for MTHFR gene variations.
This supplement provides methylated B2 as R-5-P riboflavin-5-phosphate, B6 as P-5P pyridoxal-5-phosphate, methylfolate as calcium L-5-methyltetrahydrofolate (1,666mcg), plus two forms of methylated B12: methylcobalamin (900mcg) and dibencozide (100mcg). Enhanced with 100mg of trimethylglycine (TMG) to support healthy methylation cycles and homocysteine metabolism, this formula can be combined with regular multivitamins for those wanting both inactive and active forms.
What We Like
- Contains only activated vitamin forms
- High-dose methylfolate for MTHFR support
- Two bioactive B12 forms for comprehensive coverage
- Includes TMG for methylation pathway support
- Can combine with standard multivitamins
What Could Be Better
- Limited to six nutrients rather than full multivitamin
- May be overly strong for those without MTHFR
Bottom Line: People with confirmed MTHFR gene mutations or severe methylation issues will benefit from Double Wood’s potent, purely activated formula designed to bypass genetic conversion difficulties.
3. Eliixr Methylated Multivitamin 27-in-1 – Best Value
- Advanced Methylation Support: Features active methylated folate (5-MTHF) and methylcobalamin (B12) to promote healthy methylation, optimal cellular function, and energy production.
- Full Methylated B-Complex: Includes all 8 essential B vitamins, featuring methylcobalamin and Active Folate, vital for cellular energy, metabolism, and brain health. Multivitamin for Men & Women.
- Single easy-to-swallow capsule delivers 27 natural vitamins and micronutrients, plus potent antioxidants like CoQ10, Alpha-Lipoic Acid, Choline, Zinc, and Selenium.
- Natural Variation Expected: Due to the pureness of our formula and the presence of active ingredients (B12 and folate), a strong smell and natural color variations may occur. This confirms you have high-quality methylated vitamins.
- Quality You Can Trust: Proudly made in the USA. Tested for purity and potency. Our pure methylated multivitamin is free from gluten, GMOs, lactose, binders, and nuts.
Eliixr packs 27 essential nutrients including 1,500mcg of active folate into a single easy-to-swallow capsule for ultimate convenience.
This comprehensive formula features bioactive L-5-MTHF active folate and methylcobalamin B12 your body can use immediately, along with complete methylated B-complex. Additional nutrients include vitamins A, C, D3 (50mcg), E, and K2 as menaquinone-7, plus essential minerals like zinc, selenium, manganese, and chromium. Potent antioxidants CoQ10, alpha-lipoic acid, choline, lutein, and lycopene provide comprehensive cellular protection and energy support.
What We Like
- Exceptionally high 1,500mcg active folate per capsule
- Single capsule daily for easy compliance
- Made in USA with purity testing
- Free from gluten, GMOs, lactose, and nuts
- Natural color and smell variations confirm active ingredients
What Could Be Better
- Strong natural odor may be off-putting
- High folate dose may be excessive for some
Bottom Line: If you want comprehensive methylated nutrition in the most convenient single-capsule format with premium antioxidant support, Eliixr delivers exceptional breadth and potency.
4. Igennus Methylated Men’s Multivitamin – Best All-Day Coverage
- METHYLATED & ACTIVE FORMS: each nutrient form has been carefully selected to optimize the journey from supplement to cell. Includes methylated B-vitamins, chelated minerals and gentle zinc (new label, same advanced formula, you may receive either label)*
- SLOW-RELEASE FORMULA: blood nutrient levels are optimized with bioactive vitamin forms & slow-release formula. Take 1 tablet twice per day as a split dose
- MULTIVITAMIN FOR MEN: 22 high-potency nutrients including bioactive B-complex, chelated minerals and antioxidant complex enhanced with lycopene; iron-free
- MORE OF WHAT YOU NEED, LESS OF WHAT YOU DON'T - our nutritionists have formulated a comprehensive multivitamin for men, topping up nutrients often lacking in everyday diets, without unnecessary extras*
- PURE & CLEAN: lab-verified ingredients; UK GMP manufactured; vegan; no silicon dioxide or magnesium stearate; fully recyclable packaging; easy-to-swallow oval tablets
Igennus employs slow-release technology with twice-daily dosing to maintain steady nutrient levels throughout the day.
This advanced formula contains 22 high-potency nutrients including methylated B-vitamins, chelated minerals, and antioxidant complex enhanced with lycopene for prostate and cellular health support. The carefully selected nutrient forms optimize the journey from supplement to cell, including methylfolate as L-[6S]-5-methyltetrahydrofolate, B6 as pyridoxal-5-phosphate, and B12 as methylcobalamin. Fully reacted zinc and copper bisglycinate ensure optimal absorption in balanced ratios.
What We Like
- Slow-release formula for all-day nutrient coverage
- Split dosing optimizes blood nutrient levels
- Includes lycopene for men’s health
- Chelated minerals for superior absorption
- Iron-free formulation
What Could Be Better
- Requires two tablets daily at different times
- Higher price point for 60-tablet supply
Bottom Line: Men seeking sustained nutrient release with targeted prostate support will appreciate Igennus’s scientifically formulated slow-release technology and premium ingredient selection.
5. NatureGenX Just One Daily Methylated Multivitamin – Best Iron-Free
- FORMULATED FOR ABSORPTION: Experience superior nutrient absorption with our one a day multivitamin featuring body-ready methylated vitamins, perfect for everyone including those known MTHFR gene mutation. Efficient methylation, no conversion needed, activating instantly in your body to effortlessly fill your daily nutrient needs.
- 2 MONTHS SUPPLY BALANCED WELL-BEING WITH IRON-FREE MULTIVITAMINS FOR ADULTS; MEN & WOMEN: Unlock a healthier you with our 60-capsule, 2-month supply of NatureGenX Methylated Multivitamin. packs 27 nutrients to fill modern diet gaps and conveniently helps bone, immune, metabolic, antioxidant and cardiovascular health - giving you complete, balanced nutrition in just one capsule.
- BIOAVAILABLE METHYLFOLATE FOR HOMOCYSTEINE BALANCE: Our MTHFR multivitamin without folic acid boasts Choline, methyl folate (5-MTHF), Methyl B12, B6, and other methylated B vitamins. This combination supports a healthy homocysteine balance and metabolism, contributing to overall wellness.
- USA-MADE & QUALITY ASSURANCE: Rest easy knowing NatureGenX Methylated Multivitamin is proudly made in the USA in an NSF/GMP facility. Soy-free and gluten-free, it adheres to the highest safety standards. Unlike some imported products "Packaged in the USA", we ensure integrity every step of the way for your peace of mind.
- EMBRACE NATURAL VARIATION - PURE AND UNADULTERATED: NatureGenX preserves authenticity by refraining from artificial additives. Bioactive vitamins may exhibit a natural odor due to oxidation, while speckles result from chelated minerals that enhance absorption – both entirely normal. Store in a sealed, moisture-free space or refrigerate to minimize scent and maintain product freshness.
NatureGenX provides body-ready methylated vitamins in an iron-free formula perfect for those who don’t need additional iron supplementation.
This 27-nutrient formula features Quatrefolic (6S)-5-methyltetrahydrofolate glucosamine salt, methylcobalamin B12, pyridoxal-5-phosphate B6, and complete methylated B-complex. Enhanced with CoQ10 for energy, alpha-lipoic acid for antioxidant support, choline for brain health, and key minerals including zinc, selenium, manganese, and chromium. The 60-capsule bottle provides a two-month supply with once-daily dosing.
What We Like
- Iron-free for those with adequate iron levels
- Quatrefolic methylfolate for MTHFR support
- Includes CoQ10 and ALA for cellular energy
- Made in USA in NSF/GMP facility
- Soy-free and gluten-free
What Could Be Better
- Natural odor and color variation from bioactive vitamins
- Some may prefer calcium salt methylfolate over glucosamine salt
Bottom Line: Men and postmenopausal women who need comprehensive methylated nutrition without iron will find NatureGenX provides clean, effective daily support with superior methylation-friendly forms.
6. Igennus High Potency Methylated Multivitamin for Women – Best for Women’s Wellness
- METHYLATED & ACTIVE FORMS each nutrient form has been carefully selected to optimize the journey from supplement to cell. Includes methylated B-vitamins, chelated minerals, gentle iron and zinc (new label, same advanced formula, you may receive either label)*
- PURE & CLEAN vegan, non-GMO, hypoallergenic & lab-verified ingredients with no unpleasant fillers (silicon dioxide, magnesium stearate or titanium dioxide). GMP manufactured in the UK
- HIGH POTENCY we have boosted levels of iron, B-vitamins, vitamin D and zinc in ratios that work in balance with the body. Provides enhanced support for energy, immunity, hormone balance and mood. Supplementing with iron may not be suitable for postmenopausal women*
- MORE OF WHAT YOU NEED, LESS OF WHAT YOU DON'T - our nutritionists have formulated a comprehensive multivitamin for women of menstruating age, topping up nutrients often lacking in everyday diets, without unnecessary extras*
- ALL-DAY COVERAGE this high-absorption formula is enhanced with sustained release delivery, optimizing blood nutrient levels for maximum health benefits and peace of mind. Take two, small tablets daily*
Specially formulated for women of menstruating age with boosted iron, B-vitamins, vitamin D, and zinc to support energy, immunity, and hormone balance.
This high-absorption formula features methylated B-vitamins including L-[6S]-5-methyltetrahydrofolate, pyridoxal-5-phosphate B6, and methylcobalamin B12, along with chelated minerals and gentle iron. The sustained-release technology provides steady nutrient delivery throughout the day when taking two small tablets daily. The 180-tablet supply provides three months of comprehensive women’s health support targeting energy, metabolism, hormone balance, immune function, and mood.
What We Like
- Formulated specifically for menstruating women
- Enhanced iron levels for menstrual support
- Sustained-release for all-day coverage
- Pure, clean vegan formula
- Three-month supply for excellent value
What Could Be Better
- May not be suitable for postmenopausal women due to iron
- Requires two tablets daily
Bottom Line: Women with heavy menstrual periods or those prone to iron deficiency will benefit from Igennus’s targeted formula providing enhanced iron alongside comprehensive methylated nutrition with sustained-release delivery.
7. 10X Health Optimize Multivitamin – Best Comprehensive Formula
- Targeted Nutritional Support: 10X Optimize methylated multivitamin features methylated B vitamins and minerals in a convenient multi vitamin format for everyday use, suitable for methylated multivitamin for women and methylated multivitamin for men.
- Essential Methylated Nutrients: Includes 5MTHF (methylated folic acid or methylfolate) with other methylated vitamins and Methyl B complex, such as riboflavin (B2), and pyridoxine (B6); supports straightforward daily routines without complicated stacks.
- Vital Minerals for Balance: Formulated with optimized minerals such as magnesium and zinc; a methylated multivitamin for women and men that supports balanced daily routines, pairing well with vitamin b complex with folate and methylated magnesium formats.
- Additional Methylation Support: Provides 5 MTHF (L-methylfolate) with methylated B-complex, and NAC (N-acetyl L-cysteine). NAC helps boost your body's ability to boost antioxidant levels and promote cellular health.
- Quality and Safety Focused: The 10X Optimize methylated multivitamin from 10X Health System is proudly made in the USA using premium, carefully sourced ingredients. Each batch undergoes rigorous quality and purity testing, ensuring your wellness.
10X Health delivers an extensive 34-nutrient formula with 800mcg methylcobalamin B12 and L-5-MTHF folate for comprehensive methylation support.
This advanced formula features methylated B-complex including riboflavin, pyridoxine, and high-dose methylcobalamin B12 (800mcg), plus L-5-methyltetrahydrofolate calcium for superior folate absorption. Essential minerals include calcium, magnesium, zinc, iodine, selenium, manganese, chromium, and molybdenum in optimized forms. The iron-free formula requires three capsules daily, with flexible dosing based on body weight for personalized support.
What We Like
- Extensive 34-nutrient comprehensive formula
- High-dose methylated B12 at 800mcg
- Flexible dosing based on body weight
- Suitable for both men and women
- Iron-free for those who don’t need it
What Could Be Better
- Requires three capsules daily
- Higher cost for 90-capsule supply
Bottom Line: Adults seeking the most comprehensive methylated multivitamin formula with flexible dosing options and extensive nutrient coverage will appreciate 10X Health’s thorough approach to methylation support.
How to Choose the Best Methylated Vitamins
When selecting methylated vitamins, verify the specific forms used for B-vitamins. Look for methylfolate or L-5-methyltetrahydrofolate rather than synthetic folic acid, which many people cannot convert efficiently. Quality methylated formulas use methylcobalamin and/or adenosylcobalamin for B12 instead of cyanocobalamin, pyridoxal-5-phosphate (P5P) for B6 rather than pyridoxine hydrochloride, and riboflavin-5-phosphate (R5P) for B2 instead of standard riboflavin.
MTHFR gene variations affect an estimated 40-60% of the population to varying degrees. If you’ve tested positive for MTHFR mutations (especially C677T or A1298C variants), prioritize formulas specifically designed for MTHFR support with higher methylfolate doses (typically 800-1,500mcg) and multiple methylated B-vitamins. Even without genetic testing, if you experience persistent fatigue, brain fog, mood issues, or elevated homocysteine levels despite taking regular B-vitamins, methylated forms may provide better results.
Consider whether you need a complete multivitamin with methylated B-vitamins or just a methylated B-complex to pair with your existing supplement regimen. Complete methylated multivitamins include vitamins A, C, D, E, K plus minerals alongside the methylated B-complex, offering comprehensive daily nutrition. Standalone methylated B-complex supplements focus exclusively on active B-vitamins and can be combined with regular multivitamins if desired.
Check mineral forms and dosing. Chelated minerals like zinc bisglycinate, magnesium glycinate, and selenium selenomethionine absorb more efficiently than oxide or carbonate forms. Iron-free formulas suit men and postmenopausal women, while women of childbearing age may benefit from formulations including gentle iron. However, if you already take iron separately or have hemochromatosis, choose iron-free options.
Start with the recommended dose and monitor your response. Some individuals with slow COMT enzyme variants may feel overstimulated by high-dose methylated B-vitamins, experiencing anxiety, insomnia, or irritability. If this occurs, reduce the dose or switch to a lower-potency formula. Conversely, those with MTHFR mutations often notice significant energy improvements at higher methylated vitamin doses. Adjust based on your individual biochemistry and symptoms.
Benefits of Methylated Vitamins
Methylated vitamins bypass the body’s conversion process, delivering nutrients in their active, usable forms immediately upon absorption. This is particularly crucial for individuals with MTHFR gene mutations who struggle to convert synthetic folic acid into methylfolate or standard B12 into methylcobalamin. By providing pre-activated forms, methylated vitamins ensure proper nutrient utilization regardless of genetic variations affecting methylation pathways.
The methylation cycle is fundamental to numerous critical body processes including DNA synthesis and repair, neurotransmitter production, detoxification, energy metabolism, and cardiovascular health. Inadequate methylation due to nutrient deficiencies or genetic variations can contribute to fatigue, cognitive dysfunction, mood disorders, elevated homocysteine (a cardiovascular risk marker), and impaired detoxification capacity. Methylated vitamins support optimal methylation cycle function.
Methylfolate crosses the blood-brain barrier more efficiently than synthetic folic acid, supporting neurotransmitter synthesis including serotonin, dopamine, and norepinephrine. This makes methylated B-vitamin formulas particularly valuable for supporting mood, cognitive function, and mental clarity. Research suggests methylfolate supplementation may benefit individuals with depression, especially those with MTHFR mutations or those who haven’t responded well to standard antidepressant treatments.
Proper methylation supports healthy homocysteine metabolism, converting this potentially harmful amino acid into beneficial compounds. Elevated homocysteine levels are associated with increased cardiovascular disease risk, cognitive decline, and pregnancy complications. Methylated B-vitamins, particularly methylfolate and methylcobalamin, work synergistically to maintain healthy homocysteine levels, supporting cardiovascular and neurological health.
Frequently Asked Questions
What is the difference between methylated vitamins and regular vitamins?
Regular vitamins often contain synthetic forms like folic acid and cyanocobalamin that require your body to convert them into usable forms through methylation processes. Methylated vitamins provide these nutrients in their pre-activated forms (methylfolate, methylcobalamin) that your cells can use immediately without conversion. This is especially important for people with MTHFR gene variations who cannot efficiently convert synthetic vitamins, making methylated forms significantly more effective for nutrient repletion and cellular function.
How do I know if I need methylated vitamins?
Consider methylated vitamins if you have confirmed MTHFR gene mutations through genetic testing, experience persistent fatigue or brain fog despite taking regular B-vitamins, have elevated homocysteine levels, struggle with mood issues, or notice no benefit from standard folic acid supplements. Many healthcare providers now recommend methylated forms as a precautionary approach since they’re beneficial regardless of MTHFR status and many people have undiagnosed methylation impairments.
Can methylated vitamins cause side effects?
Most people tolerate methylated vitamins well, but some individuals with slow COMT enzyme variants may experience overmethylation symptoms including anxiety, insomnia, irritability, or headaches when starting high-dose methylated B-vitamins. If this occurs, reduce the dose, take every other day initially, or choose a lower-potency formula. Starting with smaller amounts and gradually increasing helps your body adjust to the active nutrient forms.
Should I take methylated vitamins on an empty stomach?
Most methylated multivitamins are best absorbed when taken with food, as the fat-soluble vitamins (A, D, E, K) require dietary fats for optimal absorption. Food also helps minimize any potential digestive sensitivity from concentrated nutrients. However, some standalone methylated B-complex supplements can be taken on an empty stomach if preferred, though taking with food remains the safer approach for sensitive individuals.
How long does it take to see results from methylated vitamins?
Many people report increased energy and improved mental clarity within one to two weeks as nutrient levels optimize and methylation pathways function more efficiently. However, addressing deeper deficiencies and experiencing full benefits like improved mood, reduced homocysteine levels, and enhanced overall vitality typically requires eight to twelve weeks of consistent supplementation as your body rebuilds nutrient reserves and cellular function normalizes.
Can I take methylated vitamins with other supplements?
Methylated vitamins generally combine well with other supplements, though check total B-vitamin amounts if taking multiple products to avoid unnecessarily high doses. They work synergistically with omega-3 fatty acids, magnesium, and antioxidants like CoQ10. However, if you’re taking separate B-complex supplements, choose either methylated or standard forms rather than doubling up on both to prevent excessive B-vitamin intake.
Are methylated vitamins safe during pregnancy?
Methylated vitamins, particularly methylfolate, are often recommended during pregnancy as they provide more reliable folate status than synthetic folic acid, especially for women with MTHFR mutations. Adequate folate is crucial for preventing neural tube defects. However, always consult your healthcare provider before taking any supplements during pregnancy to ensure appropriate dosing and formula selection for your specific needs.
Do methylated vitamins need to be refrigerated?
Quality methylated vitamin supplements remain stable at room temperature when stored properly in cool, dry conditions away from direct sunlight and moisture. Some users prefer refrigerating them to minimize the natural odor from bioactive vitamins, though this isn’t necessary for potency. Keep the bottle tightly sealed and store in a consistent environment to maintain supplement quality throughout the shelf life.
