Best Mouthwashes for Canker Sores (2026) – Top 10 Reviewed
Canker sores can make eating, drinking, and even talking uncomfortable. The right mouthwash can provide fast pain relief while promoting healing without the burning sensation of alcohol-based products. In this guide, we’ll explore the most effective mouthwashes specifically formulated to soothe canker sores and help them heal faster.
Our Top Picks at a Glance
- Best Overall: Canker-X Rincinol — protective coating for up to 6 hours of relief
- Best Value: Prevention Mouth Sore Rinse — FDA-listed formula for tissue inflammation
- Best Premium: Orajel Antiseptic Rinse — trusted brand for comprehensive healing
Quick Comparison
| Product | Key Ingredients | Form | Size | Best For |
|---|---|---|---|---|
| Canker-X Rincinol | Aloe Vera, Hyaluronic Acid, PVP | Liquid | 4 oz | Long-lasting pain relief |
| Prevention Mouth Sore | Hydrogen Peroxide, Zinc | Liquid | 16 oz | Healing and prevention |
| Orajel Antiseptic Rinse | Hydrogen Peroxide | Liquid | 16 oz | All mouth sores |
| Prevention Daily Care | Hydrogen Peroxide, Menthol | Liquid | 16 oz | Daily prevention |
| CloSYS Sensitive | Cloralstan | Liquid | 32 oz | Sensitive mouths |
| Prevention Oncology | Glycerin, Sodium Citrate | Liquid | 16 oz | Treatment-related sores |
| Orajel 2-Pack | Hydrogen Peroxide | Liquid | 32 oz total | Long-term use |
1. Canker-X Rincinol Oral Rinse — Best Overall
- FAST PAIN RELIEF & HEALING MOUTHWASH: Canker-X canker sore treatment mouthwash provides fast, long-lasting pain relief without any burning or numbing sensation. Canker-X mouthwash is a clinically tested benzocaine-free and alcohol-free formula
- MOUTH SORES TREATMENT: Canker-X soothes canker sores, cheek bites, mouth burns, gum sores, abrasions from braces and dentures, and other types of mouth sores, relieving pain and promoting healing, while blocking irritants like food and drinks
- SOOTHES, HYDRATES & PROTECTS: With the goodness of Aloe Vera, Sodium Hyaluronate and Polyvinylpyrrolidone (PVP), this oral care mouthwash works by forming a micro-thin protective coating over mouth sores to quickly relieve pain for up to 6 hours
- HOW TO USE: Measure 10ml of this canker sore mouthwash using the enclosed cap, and swish it around your mouth for 1 minute. Avoid eating or drinking for at least 1 hour. The Canker-X mouthwash has a pleasant taste and is ideal for multiple mouth sores
- SAFE & EFFECTIVE: Clinically tested, Canker-X Rincinol Oral Mouthwash is an effective canker sore treatment for both children (6+ years) and adults even if swallowed. Use as needed
Canker-X delivers fast, long-lasting pain relief using advanced protective coating technology without any burning or numbing sensation.
This clinically tested formula combines aloe vera, sodium hyaluronate, and polyvinylpyrrolidone (PVP) to create a micro-thin protective barrier over canker sores. You’ll experience relief for up to 6 hours while the coating blocks irritants from food and drinks. The benzocaine-free, alcohol-free formula is safe for children 6+ and adults, even if accidentally swallowed.
What We Like
- Protective coating provides up to 6 hours of pain relief
- No burning, stinging, or numbing sensation
- Clinically tested and safe if swallowed
- Blocks food and drink irritants from touching sores
What Could Be Better
- Smaller 4 oz bottle means more frequent purchases
- Higher price per ounce than other options
Bottom Line: The gold standard for canker sore relief with innovative coating technology that provides hours of comfort without harsh chemicals.
2. Prevention Mouth Sore Rinse — Best Value
- Effective Mouth Sore Treatment: Specially designed for canker sores, ulcers, and irritation caused by braces, burns or minor injuries, this mouth rinse provides fast, soothing relief while supporting healing and oral comfort. Ideal for managing sensitive oral tissue and protecting against further irritation.
- Alcohol-Free & Gentle Formula: Formulated with hydrogen peroxide, sodium citrate, zinc, and glycerin that work together to provide effective pain relief and protect irritated areas in the mouth, lips, and throat. Made without alcohol, fluoride, or dyes, making it safe for short term daily use and sensitive oral care.
- Long-Lasting Freshness: Infused with natural menthol and peppermint oil, this refreshing healing mouthwash offers 12 hours of fresh breath while relieving discomfort from mouth sores, ulcers, gum disease and other oral issues.
- Safe and Easy to Use: This canker sore mouthwash is safe for adults and children aged 2 and older. With early and consistent use, it helps prevent oral discomfort while supporting a healthy, balanced oral environment. For best results, rinse 3-5 times daily or as needed to relieve pain, promote healing, and protect against future irritations.
- Hydrating & Restorative Care: Rehydrates and moisturizes the oral cavity, ensuring a comfortable experience while serving as an effective mouth sore treatment. Helps to prevent canker sores inside the mouth, dry mouth, and general irritation.
This FDA-listed oral debriding agent combines healing power with pain relief at an excellent price point.
Prevention Mouth Sore Rinse uses hydrogen peroxide with sodium citrate, zinc, and glycerin to heal and protect irritated oral tissues. The formula rehydrates and moisturizes while natural menthol and peppermint oil provide 12 hours of fresh breath. If you’re prone to canker sores from braces, stress, or other triggers, this helps prevent new sores while treating existing ones.
What We Like
- FDA-listed for managing tissue inflammation
- Hydrogen peroxide promotes healing and cleansing
- 12-hour fresh breath protection
- Rehydrates dry mouth that can worsen sores
What Could Be Better
- Requires 3-5 daily rinses for best results
- Hydrogen peroxide taste may not appeal to everyone
Bottom Line: An effective, affordable canker sore treatment that combines healing ingredients with preventive benefits for long-term oral health.
3. Orajel Alcohol-Free Antiseptic Rinse — Best Premium
- Kills bacteria
- Promotes healing of sores inside mouth
- Mint flavor
- Alcohol-Free
Orajel’s trusted antiseptic formula promotes healing of canker sores while soothing all types of mouth irritation.
This gentle rinse is specially formulated to address canker sores, gum irritation, cheek bites, and denture discomfort. The alcohol-free hydrogen peroxide formula promotes healing without the harsh sting of traditional mouthwashes. You can use it up to 4 times daily for effective relief, and the refreshing mint flavor makes it pleasant to use throughout the day.
What We Like
- Trusted Orajel brand with proven effectiveness
- Promotes healing while providing pain relief
- Works on multiple types of mouth sores
- Pleasant mint flavor without alcohol burn
What Could Be Better
- Not recommended for use longer than 7 days without doctor guidance
- May be more than needed for occasional canker sores
Bottom Line: A reliable, comprehensive solution from a trusted oral care brand that effectively treats canker sores and other mouth irritations.
4. Prevention Daily Care Mouthwash — Best for Prevention
- Effective Mouth Sore Treatment: Specially designed for canker sores, ulcers, and irritation caused by braces, burns or minor injuries, this mouth rinse provides fast, soothing relief while supporting healing and oral comfort. Ideal for managing sensitive oral tissue and protecting against further irritation.
- Alcohol-Free & Gentle Formula: Formulated with hydrogen peroxide, sodium citrate, zinc, and glycerin that work together to provide effective pain relief and protect irritated areas in the mouth, lips, and throat. Made without alcohol, fluoride, or dyes, making it safe for short term daily use and sensitive oral care.
- Long-Lasting Freshness: Infused with natural menthol and peppermint oil, this refreshing healing mouthwash offers 12 hours of fresh breath while relieving discomfort from mouth sores, ulcers, gum disease and other oral issues.
- Safe and Easy to Use: This canker sore mouthwash is safe for adults and children aged 2 and older. With early and consistent use, it helps prevent oral discomfort while supporting a healthy, balanced oral environment. For best results, rinse 3-5 times daily or as needed to relieve pain, promote healing, and protect against future irritations.
- Hydrating & Restorative Care: Rehydrates and moisturizes the oral cavity, ensuring a comfortable experience while serving as an effective mouth sore treatment. Helps to prevent canker sores inside the mouth, dry mouth, and general irritation.
Prevent future canker sores while maintaining excellent oral health with this gentle daily rinse.
Prevention Daily Care uses hydrogen peroxide to create a healthy oral environment that helps prevent canker sores from forming. The alcohol-free, fluoride-free formula with natural menthol and peppermint oil provides 12 hours of fresh breath while supporting gum health. If you get canker sores frequently, consistent daily use can help reduce their occurrence.
What We Like
- Helps prevent canker sores with regular use
- Gentle hydrogen peroxide formula
- Safe for ages 2+ for family use
- Supports overall gum and oral health
What Could Be Better
- More focused on prevention than acute pain relief
- May take consistent use to see preventive benefits
Bottom Line: An excellent choice if you’re prone to frequent canker sores and want to prevent them while maintaining daily oral hygiene.
5. CloSYS Sensitive Mouthwash — Best for Sensitive Mouths
- ENHANCED COQ10 WITH PQQ: Our CoQ10 400mg, with a 120-day supply, boosts natural CoQ10 levels for heart health. Combined with PQQ, it enhances mitochondrial energy production, vital for efficient energy and optimal heart function
- HIGH BIOAVAILABILITY: ZEBORA CoQ10 is enhanced with Black Pepper Extract and Sunflower Lecithin for superior absorption and bioavailability. Black Pepper offers antioxidant benefits, while sunflower lecithin supports skin and liver health
- OPTIMAL COMBINED OMEGA-3: Every Coq10 softgel contains 60 mg of omega-3s, which are imperative to promoting heart health. Omega-3s can improve sleep quality, support the eyes, skin, and brain health. Better absorption, better taste, and no fishy burps
- BENEFITS FOR STATIN USERS: CoQ10 is crucial for producing 95% of your body's energy, but levels decline with statin use. Supplementing with CoQ10 during statin therapy helps replenish lost levels, supporting energy production and overall organ function
- NATURAL AND PURE: All our products are third-party tested and are manufactured in a cGMP-certified facility. No Artificial Flavors or Sweeteners, No Sugar, No Starch, No Gluten, No Soy, No Wheat, and Sodium-free
Ultra-gentle pH-balanced formula that won’t irritate canker sores or sensitive oral tissues.
CloSYS uses patented Cloralstan technology to kill bad breath germs and fight bacteria without any burning sensation. The pH-balanced formula is as gentle as water, making it ideal if you have active canker sores or extremely sensitive gums. While it’s not specifically a canker sore treatment, its gentleness makes it perfect for daily oral care when you have sores.
What We Like
- pH balanced to be as gentle as water
- Zero burning or stinging on active sores
- Clinically proven 24-hour breath protection
- Won’t disrupt healing or irritate tissues
What Could Be Better
- Not formulated specifically for canker sore healing
- Premium price point
Bottom Line: The gentlest option for maintaining oral hygiene when you have active canker sores without causing additional pain or irritation.
6. Prevention Oncology Mouthwash — Best for Treatment-Related Sores
- Oncology Specific Formulation - Prevention’s’ over-the-counter (OTC) oncology mouth sore mouthwash has been formulated for use by patients going through chemotherapy and radiation treatment. These treatments can result in uncomfortable mouth sores, ulcers, dry mouth, and other oral complications. This gentle alcohol free mouthwash helps soothe, alleviate and control these side effects, while helping to retain moisture and protect the mucosal lining. The perfect mouth sores treatment for temporary relief of minor discomfort and irritated areas in a sore mouth and sore throat.
- Soothes & Protects - Unlike standard gum mouthwash products that contain alcohol and other additives, our mouthwash is designed to work with your mouth’s natural functions to support overall oral and gum care. Our mouthwash has no artificial colors or SLS, is alcohol-free and fluoride-free, making it a safe and gentle rinse for oral health support while undergoing treatment.
- Formulated for Sensitive Mouths - Oncology treatments can lead to oral taste sensitivity and irritation of mouth and throat, so our Oncology mouthwash rinse was created with the goal of minimizing irritants found in other rinses. Our highly effective oral rinse mouthwash features a low-concentration hydrogen peroxide to oxygenate under the gum line to support and maintain gum health, and glycerin to soothe and protect the oral cavity. It acts as a medicated mouthwash to provide temporary pain relief for irritated areas in the mouth, lips and throat, while rehydrating and moisturizing to alleviate dry mouth symptoms.
- Safe & Easy To Use - This alcohol free mouth wash is safe for all ages over 2 years old and easy to use. Early and regular use of this oral mouthwash will aid in protecting against dry mouth and uncomfortable oral complications. Our rinse is a convenient alternative or supplement for magic mouthwash and may be used in conjunction with other Oncology treatments. We recommend rinsing 3-5 times a day when undergoing chemotherapy and/or radiation treatments.
- Prevention Health Sciences - Good oral health begins with Prevention! Our complete line of dental rinse and mouthwashes are free of harsh chemicals and ingredients, always naturally flavored, alcohol-free and without any SLS or artificial colors. Our line of oral care products are recommended by health care professionals for both Oncology related oral issues as well as everyday oral care and protection.
Specially formulated for mouth sores related to chemotherapy and radiation treatment.
This gentle rinse addresses the severe mouth sores that can develop during cancer treatment. The alcohol-free, fluoride-free formula with no artificial colors or SLS helps soothe discomfort, retain moisture, and protect the mucosal lining. While designed for oncology patients, it’s also effective if you develop canker sores from medications or immune system issues.
What We Like
- Formulated for severe treatment-related mouth sores
- Helps retain moisture in chronically dry mouths
- Free of all harsh chemicals and additives
- Recommended by healthcare professionals
What Could Be Better
- May be more specialized than needed for typical canker sores
- Higher price reflects medical-grade formulation
Bottom Line: A compassionately designed rinse for severe mouth sores, whether from cancer treatment or other medical conditions causing frequent canker sores.
7. Orajel Alcohol-Free Antiseptic Rinse 2-Pack — Best Long-Term Value
- GENTLE ON SENSITIVE MOUTHS: The alcohol-free formula is perfect for those with sensitive teeth or gums, providing relief without irritation
- FRESH MINT FLAVOR: Enjoy a pleasant and refreshing minty taste that leaves your mouth feeling invigorated
- MULTI-BENEFIT FORMULA: Soothe discomfort, cleanse your mouth, and freshen your breath – all in one easy-to-use rinse
- CONVENIENT AND LONG-LASTING: Offers plenty of rinses, making it ideal for home or travel use
- CLINICALLY PROVEN: Orajel has been trusted by families for generations, with this rinse clinically tested to deliver effective results
Stock up on effective canker sore treatment with this economical 2-pack.
You’ll get two 16-ounce bottles of Orajel’s proven antiseptic formula that promotes healing of canker sores and other mouth irritations. This value pack is ideal if you’re prone to frequent canker sores and want to ensure you always have treatment on hand. The fresh mint formula provides relief without the harsh burning of alcohol-based products.
What We Like
- Economical 2-pack for long-term use
- Same effective Orajel formula
- Always have treatment available when sores appear
- Better value than buying individual bottles
What Could Be Better
- Larger upfront cost
- Product may expire if canker sores are infrequent
Bottom Line: A smart investment if you deal with canker sores regularly and want to keep effective treatment stocked at home.
How to Choose the Best Mouthwash for Canker Sores
When selecting a canker sore mouthwash, your first consideration should be whether you need immediate pain relief or preventive care. Products like Canker-X with protective coating technology provide fast, long-lasting relief for active sores, while hydrogen peroxide-based rinses like Prevention offer both treatment and prevention benefits. If you get canker sores frequently, look for formulas that support overall oral health to help prevent future outbreaks.
Alcohol-free formulas are absolutely essential for canker sore treatment. Alcohol causes intense burning on open sores and can actually delay healing by drying out the affected tissue. Every product in this guide is alcohol-free specifically because gentle, non-irritating ingredients are crucial when dealing with painful mouth sores.
Pay attention to the active ingredients and how they work. Hydrogen peroxide-based rinses cleanse and promote healing through oxygenating action that removes debris. Coating formulas like those containing aloe vera, hyaluronic acid, or PVP create a protective barrier over sores. Some products combine multiple approaches for comprehensive relief and healing support.
Consider how often you’ll need to use the mouthwash. Some therapeutic rinses recommend 3-5 times daily for active sores, while others provide longer-lasting relief with less frequent use. Think about your lifestyle and which approach fits better—if you’re at work or school all day, a product offering 6-hour protection might be more practical than one requiring frequent reapplication.
Finally, look at ingredients that support healing beyond just pain relief. Zinc, glycerin, and natural botanicals like aloe vera can promote faster healing and tissue repair. If you’re sensitive to flavors or have dietary restrictions, check for products that are free of artificial colors, sweeteners, or common allergens.
Benefits of Mouthwash for Canker Sores
The primary benefit of specialized canker sore mouthwashes is rapid pain relief without the burning sensation of traditional products. Unlike alcohol-based mouthwashes that cause intense stinging on open sores, these gentle formulas provide comfort immediately. Many users report significant pain reduction within minutes of rinsing, making eating, drinking, and speaking much more comfortable.
These mouthwashes actively promote faster healing through several mechanisms. Hydrogen peroxide formulas create an oxygen-rich environment that helps clean the sore and remove debris that can slow healing. Coating products create a protective barrier that shields the sore from irritants like acidic foods, hot beverages, and bacteria, allowing your body’s natural healing processes to work more efficiently.
Regular use can help prevent new canker sores from forming, especially if you’re prone to frequent outbreaks. By maintaining a healthy oral environment with balanced pH and reduced bacteria levels, these rinses address some of the underlying factors that contribute to canker sore development. Many users find that consistent daily use significantly reduces the frequency and severity of their canker sores over time.
Beyond canker sore treatment, these gentle formulas benefit your overall oral health. They reduce inflammation, support gum health, and maintain a balanced oral microbiome without the harsh effects of alcohol. This makes them suitable for long-term use as part of your daily oral hygiene routine, providing ongoing protection against mouth sores while supporting general oral wellness.
Frequently Asked Questions
What is the fastest way to heal a canker sore with mouthwash?
For fastest healing, use a canker sore-specific mouthwash like Canker-X or Prevention Mouth Sore Rinse 3-5 times daily, especially after meals. The combination of protective coating (with Canker-X) or hydrogen peroxide cleansing (with Prevention) promotes healing while preventing irritation from food and drinks. Consistent use from the moment you notice a sore developing can significantly reduce both pain and healing time.
Should I use mouthwash if I have a canker sore?
Yes, but only alcohol-free mouthwashes specifically formulated for canker sores. Regular alcohol-based mouthwashes will cause intense burning and can delay healing by drying out the sore. Specialized canker sore rinses like those in this guide provide pain relief while promoting healing. Avoid any mouthwash containing alcohol, which appears on the ingredient list as ethanol or ethyl alcohol.
How often should I rinse with canker sore mouthwash?
Most canker sore mouthwashes recommend rinsing 3-5 times daily for active sores, typically after meals and before bed. Products like Canker-X that provide longer-lasting relief may require less frequent use, while hydrogen peroxide rinses work best with more consistent application throughout the day. Always follow the specific product instructions for optimal results.
Can mouthwash prevent canker sores from coming back?
Regular use of gentle, pH-balanced mouthwashes can help reduce canker sore frequency for many people. Products like Prevention Daily Care maintain a healthy oral environment that’s less conducive to canker sore formation. While they can’t completely prevent canker sores caused by stress, hormonal changes, or nutritional deficiencies, they address the oral health factors that contribute to outbreaks.
What ingredients should I look for in a canker sore mouthwash?
Look for hydrogen peroxide for gentle cleansing and healing promotion, aloe vera for soothing inflammation, hyaluronic acid for moisture and tissue repair, and zinc for antimicrobial properties. Avoid alcohol, SLS (sodium lauryl sulfate), artificial colors, and harsh chemicals. Natural ingredients like menthol and peppermint oil can provide freshness without irritation.
Is hydrogen peroxide mouthwash good for canker sores?
Yes, hydrogen peroxide is excellent for canker sores. It creates an oxygen-rich environment that helps clean the sore, remove debris, and promote healing. Products like Prevention Mouth Sore Rinse and Orajel Antiseptic Rinse use hydrogen peroxide as their active ingredient. The gentle oxygenating action cleans without harsh scrubbing or chemical irritation that could worsen the sore.
How long does it take for canker sore mouthwash to work?
Pain relief typically begins within minutes of rinsing, especially with protective coating formulas like Canker-X. Complete healing usually takes 7-14 days with consistent use, though many people notice significant improvement within 3-5 days. Starting treatment as soon as you feel a canker sore developing can reduce both pain intensity and overall healing time.
Can I use canker sore mouthwash every day?
Yes, most canker sore mouthwashes are safe for daily use. Products like Prevention Daily Care are specifically designed for daily oral hygiene to help prevent future canker sores. However, some therapeutic rinses like Orajel recommend limiting continuous use to 7 days unless directed by a dentist or doctor. Check the specific product instructions for guidance on long-term use.
