Best Nattokinase Supplements for Circulation (2026) – Top 10 Reviewed
Nattokinase is a powerful enzyme derived from natto, a traditional Japanese fermented soybean dish that has been consumed for over 1,000 years. This fibrinolytic enzyme supports healthy blood flow by helping break down fibrin—a protein involved in blood clot formation—making it one of the most researched natural circulation supplements available today.
The best nattokinase supplements deliver adequate enzyme activity (measured in FU—fibrinolytic units), use quality sourcing from traditional Japanese fermentation, and undergo third-party testing for potency and purity. Look for products providing at least 2,000 FU per serving, and consider whether you need a standalone formula or a multi-ingredient blend for comprehensive cardiovascular support. Here are our top 10 picks for 2026.
| Product | Key Ingredients | Servings | Form | Best For |
|---|---|---|---|---|
| Toku Flow Nattokinase | 10,800 FU Nattokinase, Vitamin K2 MK7, Oat Beta Glucan | 30 | Powder Packets | Best Overall |
| Luma Nutrition Nattokinase | 4,000 FU Nattokinase | 60 | Capsules | Best for Daily Use |
| Double Wood Nattokinase | 4,000 FU Nattokinase | 60 | Capsules | Best High-Potency |
| Doctor’s Best Nattokinase | 2,000 FU Nattokinase (Vitamin K2 removed) | 90 | Capsules | Best Value |
| Pure Encapsulations NSK-SD | 2,000 FU NSK-SD Nattokinase | 120 | Capsules | Best Premium |
| Nutricost Nattokinase | 2,000 FU Nattokinase | 120 | Capsules | Best Budget |
| Melody Heart Tune 4-in-1 | 2,400 FU Nattokinase, Reishi, Hawthorn | 60 | Capsules | Best Multi-Ingredient |
| Spike Detox 3-in-1 Enzyme | 10,000 FU Nattokinase, Serrapeptase, Bromelain | 90 | Tablets | Best Enzyme Combo |
| HUJ BIO CARDIOONE 14-in-1 | Nattokinase, L-Arginine, L-Citrulline, Black Garlic | 60 | Capsules | Best Comprehensive Formula |
| Toku Nattokinase Powder | 10,800 FU Nattokinase, Vitamin K2 MK7 | 30 | Powder Packets | Best Powder Form |
1. Toku Flow Nattokinase – Best Overall
Why it stands out: Toku Flow delivers an exceptionally high 10,800 FU of nattokinase per serving—more than five times what most competitors offer. The convenient single-serve powder packets make it easy to incorporate into your daily routine, and the pleasant chocolate flavor masks the typical fermented taste that can make natto-derived products unappealing to Western consumers.
This functional daily powder combines nattokinase with vitamin K2 MK7 and oat beta glucan for comprehensive cardiovascular support. Vitamin K2 helps direct calcium to bones rather than arteries, while oat beta glucan supports healthy cholesterol levels—creating a synergistic formula that addresses multiple aspects of heart health. The soy-free formula appeals to those with soy sensitivities, which is notable since most nattokinase is derived from fermented soybeans.
The plant-based formula uses a proprietary extraction process that delivers pure nattokinase without common allergens. Each box contains 30 packets for a full month’s supply, and the powder dissolves easily in water, coffee, or smoothies without clumping. The chocolate flavor is subtle enough to blend well with other beverages while making the supplement more enjoyable to take consistently.
Pros:
- Highest potency available at 10,800 FU per serving
- Soy-free formulation—rare for nattokinase products
- Pleasant chocolate flavor improves compliance
- Includes synergistic ingredients like vitamin K2 and beta glucan
Cons:
- Premium price point compared to capsule alternatives
- Requires mixing rather than quick-swallow convenience
Best for: Those seeking maximum nattokinase potency and a convenient powder format for daily cardiovascular support.
2. Luma Nutrition Nattokinase – Best for Daily Use
Why it stands out: Luma Nutrition offers a straightforward, high-quality nattokinase supplement at 4,000 FU per serving—double the standard dose. The vegan, gluten-free formula is manufactured in the USA and provides excellent heart health support without unnecessary additives.
Each bottle contains 60 capsules, providing a two-month supply when taken at the standard one-capsule-per-day dosage. The capsules are easy to swallow and digest, making them ideal for daily supplementation. Luma Nutrition has built a reputation for clean, effective formulas, and their nattokinase is no exception. The company uses quality-controlled manufacturing processes and sources their nattokinase from traditional Japanese natto fermentation.
Pros:
- High 4,000 FU potency per capsule
- Two-month supply per bottle
- Vegan and gluten-free
- Clean formula with minimal fillers
Cons:
- Contains soy (derived from fermented soybeans)
Best for: Anyone looking for a reliable, high-potency daily nattokinase supplement without extra ingredients.
3. Double Wood Nattokinase – Best High-Potency
Why it stands out: Double Wood has earned a strong reputation in the supplement industry for quality and transparency. Their nattokinase delivers 4,000 FU per serving (two capsules of 2,000 FU each), giving you flexibility in dosing while maintaining high potency.
Manufactured in the USA in a GMP-compliant facility, Double Wood’s nattokinase undergoes rigorous third-party testing for purity and potency. The vegetarian, non-GMO, gluten-free capsules are derived from Japanese natto. With 120 capsules per bottle, you get a full two-month supply at the recommended dosage. The company provides transparent labeling and makes their third-party test results available upon request, demonstrating their commitment to quality.
Pros:
- 4,000 FU per two-capsule serving
- Third-party tested for quality assurance
- 120 capsules per bottle (two-month supply)
- Excellent value for a high-potency option
Cons:
- Requires taking two capsules for full dose
Best for: Those who want a trusted brand with transparent quality standards and flexible dosing options.
4. Doctor’s Best Nattokinase – Best Value
Why it stands out: Doctor’s Best is a science-based supplement company with over 35 years of experience, and their nattokinase formula is one of the most trusted and affordable options on the market. Notably, they remove vitamin K2 from their nattokinase, making it suitable for those on blood-thinning medications who need to avoid vitamin K—a crucial feature that many competing products don’t offer.
Each vegetarian capsule delivers 2,000 FU of nattokinase, and the 90-count bottle provides a three-month supply at the standard once-daily dosage. The formula is non-GMO, vegan, and gluten-free, though it does contain soy since the nattokinase is derived from fermented soybeans.
Doctor’s Best sources their nattokinase from traditional Japanese natto fermentation using Bacillus subtilis bacteria, maintaining the authentic production method that has been used in Japan for centuries. The company’s commitment to science-backed formulations and quality manufacturing has made this one of the best-selling nattokinase supplements available on Amazon and through health food stores. ConsumerLab has included Doctor’s Best in their nattokinase testing, adding independent verification to its credibility.
The vitamin K2 removal process is carefully controlled to ensure the fibrinolytic enzyme activity remains intact while eliminating the vitamin that could interfere with anticoagulant medications. This makes Doctor’s Best one of the safest choices for those managing their cardiovascular health with prescription blood thinners.
Pros:
- Vitamin K2 removed—safer for those on blood thinners
- 90-day supply at an affordable price
- Science-backed brand with 35+ years of experience
- Non-GMO, vegan, gluten-free
- Included in ConsumerLab testing
Cons:
- Lower potency at 2,000 FU (standard dose)
- Contains soy
Best for: Budget-conscious buyers and those who need a nattokinase supplement without vitamin K for safe use alongside blood-thinning medications.
5. Pure Encapsulations NSK-SD – Best Premium
Why it stands out: Pure Encapsulations is known as a hypoallergenic supplement brand trusted by healthcare practitioners worldwide. Their NSK-SD formula uses a patented, highly researched form of nattokinase that has been clinically studied in Japan and the United States for its fibrinolytic activity and cardiovascular benefits—making it one of the most evidence-backed options available.
NSK-SD stands for “Nattokinase Subtilisin Deactivated,” meaning the vitamin K has been removed through a proprietary process developed by Japan Bio Science Laboratories. This patented form has been used in multiple clinical studies demonstrating its effects on fibrin degradation and healthy circulation. Each capsule provides 100mg (2,000 FU) of nattokinase, and the recommended dosage is one capsule twice daily, 12 hours apart, for optimal circulation support throughout the day.
The twice-daily dosing protocol is designed to maintain consistent nattokinase levels in the bloodstream, since the enzyme’s activity typically lasts 8-12 hours. This approach may provide more sustained cardiovascular support compared to once-daily products.
The formula is free from common allergens, GMOs, artificial ingredients, and unnecessary fillers—meeting the brand’s strict purity standards. Pure Encapsulations is often recommended by integrative medicine practitioners, naturopathic doctors, and functional medicine specialists for its pharmaceutical-grade quality. The company’s manufacturing processes exceed industry standards, with extensive testing for contaminants and potency verification.
Pros:
- Patented NSK-SD form extensively studied in clinical trials
- Hypoallergenic—free from common allergens and artificial ingredients
- Trusted by healthcare practitioners
- Vitamin K removed for safe use with blood thinners
- Twice-daily dosing for sustained support
Cons:
- Higher price point than other options
- Requires twice-daily dosing for optimal results
- Contains soy
Best for: Those seeking a practitioner-grade supplement with clinical research backing and the highest purity standards.
6. Nutricost Nattokinase – Best Budget
Why it stands out: Nutricost delivers exceptional value with 120 capsules of 2,000 FU nattokinase at one of the lowest prices per serving on the market. The company maintains quality through third-party testing by ISO-accredited laboratories while keeping costs down through efficient manufacturing.
Each capsule provides a standard 2,000 FU dose, and the four-month supply makes this an economical choice for long-term supplementation. The formula is gluten-free, non-GMO, and vegetarian-friendly. Nutricost manufactures in a GMP-compliant, FDA-registered facility in the USA, ensuring quality without the premium price tag. While the formula doesn’t include extra ingredients, it delivers pure nattokinase at a fraction of the cost of premium brands.
Pros:
- Outstanding value—four-month supply at a budget price
- Third-party tested by ISO-accredited labs
- Gluten-free, non-GMO, vegetarian
- Made in USA in GMP-compliant facility
Cons:
- Standard 2,000 FU potency (not high-potency)
- Contains soy
Best for: Cost-conscious consumers who want quality nattokinase without premium pricing.
7. Melody Heart Tune 4-in-1 – Best Multi-Ingredient Formula
Why it stands out: Melody Heart Tune combines nattokinase with three additional cardiovascular-supporting ingredients—reishi mushroom, hawthorn berry, and other botanicals—in a comprehensive blood pressure support formula. This doctor-formulated blend offers synergistic benefits beyond what standalone nattokinase provides.
Each serving delivers 2,400 FU of nattokinase alongside adaptogenic reishi mushroom and traditional heart-supporting hawthorn extract. The two-month supply (60 vegan capsules) targets both circulation and blood pressure support. The formula is designed for comprehensive vascular health, making it ideal for those who want to address multiple cardiovascular concerns with a single supplement. All ingredients are chosen based on traditional use and emerging research in cardiovascular wellness.
Pros:
- Four complementary ingredients for comprehensive support
- Doctor-formulated for synergistic benefits
- Includes adaptogenic reishi mushroom
- Vegan capsules
Cons:
- Lower nattokinase dose than standalone products
- More complex formula may not suit purists
Best for: Those seeking comprehensive cardiovascular support beyond fibrinolytic activity alone.
8. Spike Detox 3-in-1 Enzyme Formula – Best Enzyme Combo
Why it stands out: This powerful formula combines three systemic enzymes—nattokinase (10,000 FU), serrapeptase (18,000 SPU), and bromelain (800 GDU)—for comprehensive fibrinolytic and proteolytic support. The triple-enzyme approach provides broader systemic benefits than nattokinase alone.
With 90 tablets per bottle, this formula provides a full three-month supply. Serrapeptase complements nattokinase’s fibrin-degrading activity, while bromelain adds anti-inflammatory properties and supports protein digestion. The combination has gained popularity among those seeking comprehensive circulatory support and systemic enzyme benefits. The tablet form ensures stability of the enzyme blend, and the formula is designed for those who want maximum systemic enzyme coverage.
Pros:
- Triple-enzyme formula for comprehensive support
- Very high nattokinase potency (10,000 FU)
- Three-month supply
- Combines fibrinolytic and proteolytic enzymes
Cons:
- Tablet form may be harder to swallow than capsules
- Higher price due to multiple enzymes
Best for: Those wanting comprehensive systemic enzyme support with multiple fibrinolytic and proteolytic enzymes.
9. HUJ BIO CARDIOONE 14-in-1 – Best Comprehensive Formula
Why it stands out: CARDIOONE takes a whole-body approach to cardiovascular health by combining nattokinase with 13 additional heart-supporting ingredients including L-arginine, L-citrulline, and black garlic extract. This comprehensive formula addresses multiple aspects of vascular health beyond fibrin breakdown.
The formula includes nitric oxide precursors (L-arginine and L-citrulline) that support healthy blood vessel dilation, along with black garlic extract known for its cardiovascular benefits. The 60-capsule bottle provides a one-month supply at the recommended dosage. While the nattokinase dose is lower than standalone products, the synergistic combination of ingredients creates a comprehensive cardiovascular support formula. The vegan capsules are suitable for a wide range of dietary preferences.
Pros:
- 14 cardiovascular-supporting ingredients
- Includes nitric oxide precursors for vasodilation
- Black garlic extract for additional heart benefits
- Comprehensive approach to vascular health
Cons:
- Lower nattokinase concentration due to multiple ingredients
- Higher cost per serving
Best for: Those seeking an all-in-one cardiovascular supplement that addresses circulation, blood flow, and vascular health from multiple angles.
10. Toku Nattokinase Powder – Best Powder Form
Why it stands out: For those who prefer powders over pills, Toku’s single-serve packets deliver 10,800 FU of soy-free nattokinase with added vitamin K2 MK7. The powder format offers faster absorption and is perfect for those who have difficulty swallowing capsules.
Each box contains 30 packets for a month’s supply, and the powder mixes easily into water, juice, or smoothies. The soy-free formulation sets it apart from most nattokinase supplements, which are derived from fermented soybeans. The inclusion of vitamin K2 MK7 supports both cardiovascular and bone health, making this a well-rounded choice. The plant-based drink mix is ideal for those following vegan diets or anyone seeking an alternative to traditional capsule supplements.
Pros:
- Highest potency available (10,800 FU)
- Soy-free—rare for nattokinase products
- Easy-to-use powder packets
- Includes vitamin K2 MK7
Cons:
- Premium price point
- Requires mixing (less convenient than capsules for some)
Best for: Those who prefer powder supplements, have soy allergies, or want maximum potency in an easy-to-absorb format.
What is Nattokinase and Who Should Take It?
Nattokinase is a fibrinolytic enzyme extracted from natto, a traditional Japanese food made by fermenting soybeans with Bacillus subtilis bacteria. First identified by Dr. Hiroyuki Sumi in 1987, this enzyme has been extensively studied for its ability to break down fibrin—a protein that plays a key role in blood clot formation. Unlike pharmaceutical blood thinners, nattokinase works by enhancing the body’s natural fibrinolytic system rather than introducing synthetic compounds.
The enzyme works through multiple mechanisms: it directly degrades fibrin, increases the body’s production of plasmin (the natural clot-dissolving enzyme), and inhibits factors that promote clot formation. Research has shown that nattokinase’s fibrinolytic activity can remain in the bloodstream for 8-12 hours after ingestion, providing extended cardiovascular support throughout the day.
People who may benefit from nattokinase include those looking to support healthy circulation, maintain normal fibrinogen levels, or complement their cardiovascular wellness routine. It’s particularly popular among aging adults, those with sedentary lifestyles, frequent travelers concerned about circulation during long flights, and anyone seeking natural alternatives to support blood flow. Some people also use nattokinase as part of a broader heart-healthy regimen alongside proper diet and exercise.
However, anyone taking blood-thinning medications (warfarin, heparin, aspirin), preparing for surgery, or with bleeding disorders should consult a healthcare provider before use. Nattokinase has real physiological effects on blood clotting factors, so it should be treated with appropriate respect despite being a natural supplement.
How to Choose the Right Nattokinase Supplement
Key Factors to Look For
Enzyme activity is the most important consideration—always check the FU (fibrinolytic units) rather than just milligrams. A typical effective dose ranges from 2,000 to 4,000 FU per day, though some studies have used higher amounts. Products should clearly state their FU content on the label; if they only list milligrams without FU, the enzyme activity may be inconsistent. This is because different manufacturing processes yield varying enzyme potencies from the same weight of nattokinase.
Look for third-party testing by organizations like ConsumerLab, NSF, or ISO-accredited laboratories. This ensures the product contains what it claims and is free from contaminants. ConsumerLab’s 2025 testing found significant variability in nattokinase supplements, with some delivering much less enzyme activity than stated—one product provided less than half its claimed activity. Third-party verification is especially important for enzyme supplements where potency can degrade over time.
Consider the source and manufacturing location. Products manufactured in the USA in GMP-certified facilities typically adhere to stricter quality standards. The best nattokinase is derived from traditional Japanese fermentation methods using Bacillus subtilis natto bacteria. Some premium brands use patented forms like NSK-SD (Nattokinase Subtilisin Deactivated), which has been specifically studied in clinical trials.
Forms Compared
Capsules are the most common and convenient form, offering precise dosing and easy storage. Vegetarian capsules made from cellulose are preferred over gelatin for those with dietary restrictions. Capsules typically provide doses ranging from 2,000 to 4,000 FU per serving.
Powder formats like Toku provide faster absorption and allow for higher potencies—up to 10,800 FU per serving. They’re ideal for those who have difficulty swallowing pills or want to add nattokinase to smoothies and beverages. However, they require mixing and may have a distinct taste.
Tablets may have longer shelf stability but can be harder to swallow and may require more binders and fillers. Enteric-coated options protect the enzyme from stomach acid, potentially improving absorption in the intestines where it can enter the bloodstream more effectively.
What to Avoid
Avoid products that only list milligrams without FU activity, as enzyme potency varies significantly between manufacturers. A 100mg capsule could contain anywhere from 1,000 to 4,000 FU depending on the quality of the nattokinase extract.
Skip supplements with excessive fillers, artificial colors, or unnecessary additives. Quality nattokinase supplements should have minimal inactive ingredients—typically just the capsule material and perhaps rice flour or cellulose as a flow agent.
If you’re taking anticoagulants or blood pressure medications, avoid products that still contain vitamin K2 unless your doctor approves—look for “vitamin K removed” or “NSK-SD” formulations. Vitamin K can interfere with blood-thinning medications like warfarin by promoting clot formation.
Be wary of extremely cheap products or brands you’ve never heard of, especially those sold exclusively through third-party marketplace sellers. Enzyme supplements require careful manufacturing and storage to maintain potency.
Side Effects and Precautions
Nattokinase is generally well-tolerated when taken as directed, with most users experiencing no adverse effects. The most commonly reported side effects include mild digestive discomfort (nausea, bloating, or upset stomach), occasional headaches during the first few days of use, and in rare cases, dizziness related to blood pressure changes. Starting with a lower dose and taking it with a small snack may help minimize any initial discomfort as your body adjusts.
Due to its blood-thinning properties, nattokinase should not be taken with anticoagulant medications (warfarin, heparin), antiplatelet drugs (aspirin, clopidogrel, Plavix), or newer blood thinners (apixaban, rivaroxaban) without medical supervision. The combination could increase bleeding risk beyond safe levels. Discontinue nattokinase at least two weeks before any scheduled surgery and inform your surgeon or anesthesiologist about your supplement use.
Pregnant or nursing women should avoid nattokinase due to insufficient safety data in these populations. Those with bleeding disorders (hemophilia, von Willebrand disease), very low blood pressure, or active internal bleeding should not use nattokinase. People with soy allergies should note that most nattokinase is derived from fermented soybeans, though soy-free options like Toku are available.
If you experience unusual bruising, prolonged bleeding from minor cuts, blood in urine or stool, or severe headaches, discontinue use immediately and seek medical attention. These could indicate excessive blood-thinning effects. As with any supplement affecting cardiovascular function, periodic check-ins with your healthcare provider are recommended, especially if you have existing heart conditions or are taking other cardiovascular medications.
FAQs
How much nattokinase should I take daily?
Most studies use doses between 2,000 and 4,000 FU per day. Start with 2,000 FU and increase if needed based on your response and healthcare provider’s guidance. Some products offer higher potencies up to 10,000+ FU for those seeking more aggressive support.
When is the best time to take nattokinase?
Nattokinase is typically most effective when taken on an empty stomach—either 30 minutes before meals or 2 hours after eating. This allows the enzyme to enter the bloodstream without being degraded by digestive enzymes. Many people prefer taking it in the morning or before bed.
How long does it take to see results from nattokinase?
Most people notice effects on circulation and energy within 4-8 weeks of consistent daily use. Some studies have shown measurable changes in blood markers within 2-4 weeks. For best results, take nattokinase consistently as part of your daily routine.
Can I take nattokinase with blood pressure medication?
Nattokinase may have mild blood pressure-lowering effects, so combining it with antihypertensive medications requires medical supervision. Your doctor may need to adjust medication dosages. Never start or stop nattokinase without discussing it with your healthcare provider if you’re on blood pressure medications.
Is nattokinase safe for long-term use?
Nattokinase has been consumed as part of the traditional Japanese diet for over 1,000 years, and supplementation studies lasting several months have shown good safety profiles. However, periodic monitoring and check-ins with your healthcare provider are recommended for long-term use, especially if you have cardiovascular conditions.
What’s the difference between nattokinase and serrapeptase?
Both are proteolytic enzymes, but they work differently. Nattokinase specifically targets fibrin (involved in blood clotting), while serrapeptase has broader protein-degrading activity and is often used for inflammation and sinus support. Some supplements combine both for comprehensive systemic enzyme benefits.
Final Verdict
For most people seeking a high-quality nattokinase supplement, Toku Flow stands out as our top pick thanks to its exceptional 10,800 FU potency, soy-free formulation, and convenient powder format with added vitamin K2 and beta glucan. The premium quality justifies its higher price point for those serious about cardiovascular support.
If you’re looking for the best value without compromising quality, Doctor’s Best Nattokinase offers a trusted, science-backed formula at an affordable price—with the added benefit of vitamin K2 removal for those on blood thinners. For budget-conscious buyers, Nutricost Nattokinase delivers reliable quality and third-party testing at the lowest cost per serving.
Those seeking comprehensive cardiovascular support beyond nattokinase alone should consider Melody Heart Tune 4-in-1 or HUJ BIO CARDIOONE for their synergistic multi-ingredient formulas.
