Best Nitric Oxide Pre-Workout (2026) – Top 10 Reviewed

If you’re looking to maximize your muscle pumps, enhance blood flow, and boost workout performance, nitric oxide pre-workouts offer a powerful solution. These specialized supplements use ingredients like L-citrulline, beetroot extract, and arginine to increase nitric oxide production in your body, which dilates blood vessels and drives more blood, oxygen, and nutrients to working muscles. The result? Intense muscle pumps, improved endurance, and enhanced nutrient delivery that supports both performance and recovery. Whether you prefer stimulant-packed formulas for explosive energy or caffeine-free options for evening training, this guide covers the best nitric oxide pre-workouts to help you achieve maximum vascularity and workout intensity.

Our Top Picks at a Glance

• Best Overall: 1MD CardioFitMD — premium beet superfood for sustained NO production
• Best Value: Beet Root Gummies — affordable gummy format with COQ10
• Best Premium: Juvenon BloodFlow-7 — advanced Nitrosigine and S7 technology

Quick Comparison

Product	Key Ingredients	Form	Servings	Best For
1MD CardioFitMD	Beet root powder, nitrates	Powder	30	Premium NO support
Beet Root Gummies	Beetroot, COQ10, pomegranate	Gummies	120	Convenient option
Juvenon BloodFlow-7	Nitrosigine, S7	Capsules	60	Advanced formula
Sugar Free Beet Gummies 120ct	Beetroot, coconut oil	Gummies	120	Sugar-free choice
Raw Beet Root Powder	Cold-pressed beet powder	Powder	60+	Pure beetroot
WellPath Beet Gummies	1500mg beetroot	Gummies	60	High-dose option
EVL ENGN Shred	Caffeine, thermogenic blend	Powder	30	Energy & fat burn
Odyssey 222	222mg caffeine, mushrooms	Drink	12	Ready-to-drink
Transparent Labs BULK Black	8g citrulline, caffeine	Powder	30	Complete pre-workout
Jacked Factory Nitrosurge	L-citrulline, caffeine	Powder	30	Budget-friendly

1. 1MD Nutrition CardioFitMD — Best Overall

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1MD Nutrition CardioFitMD combines premium vegan beet superfood with high nitrate content to deliver sustained nitric oxide production.

This keto-friendly beet root powder provides 30 days of comprehensive cardiovascular and nitric oxide support through concentrated beetroot that’s naturally rich in dietary nitrates. Your body converts these nitrates into nitric oxide, promoting enhanced blood flow, muscle pumps, and cardiovascular health. The high-fiber formula supports digestive health alongside its performance benefits, making it a well-rounded supplement for both gym performance and overall wellness.

What We Like

• Premium beet superfood delivers sustained nitric oxide elevation
• Vegan and keto-friendly formula fits various dietary approaches
• High fiber content provides additional digestive health benefits

What Could Be Better

• Premium pricing reflects high-quality ingredients
• Powder format requires mixing before each use

Bottom Line: 1MD CardioFitMD offers the most comprehensive nitric oxide support through concentrated beetroot that enhances blood flow for better pumps, endurance, and cardiovascular health.

2. Beet Root Gummies with COQ10 & Pomegranate — Best Value

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These beetroot gummies combine nitric oxide support with COQ10 and pomegranate for comprehensive cardiovascular and performance enhancement.

With 120 gummies providing a two-month supply, this mixed berry formula makes nitric oxide supplementation convenient and delicious. The combination of beetroot for NO production, COQ10 for cellular energy, and pomegranate for antioxidant support creates synergistic benefits for workout performance and recovery. These vegan, non-GMO, gluten-free gummies deliver effective pump support without the hassle of mixing powders or swallowing large capsules.

What We Like

• Combines beetroot with COQ10 and pomegranate for multi-pathway support
• 120-count bottle provides excellent value for two months of use
• Delicious mixed berry flavor makes supplementation enjoyable

What Could Be Better

• Contains natural sugars unlike sugar-free alternatives
• May provide lower nitrate concentration than powder options

Bottom Line: These beetroot gummies offer outstanding value by combining effective nitric oxide support with cardiovascular-enhancing ingredients in a convenient, great-tasting format.

3. Juvenon BloodFlow-7 XXXL — Best Premium

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Juvenon BloodFlow-7 XXXL uses cutting-edge Nitrosigine and S7 ingredients for more powerful, longer-lasting nitric oxide elevation.

This premium formula represents advanced nitric oxide technology, utilizing patented Nitrosigine that provides sustained NO production for up to six hours. The S7 ingredient blend has been clinically shown to increase nitric oxide levels by 230%, far exceeding what traditional ingredients can achieve. This capsule-format supplement works for both men and women seeking enhanced blood flow and circulation support without any stimulants, making it perfect for evening workouts or daily cardiovascular health.

What We Like

• Patented Nitrosigine delivers extended 6-hour nitric oxide elevation
• S7 ingredient blend clinically proven to boost NO by 230%
• Stimulant-free formula suitable for any time of day

What Could Be Better

• Premium price reflects advanced patented ingredients
• Full effects may require several days of consistent use

Bottom Line: Juvenon BloodFlow-7 XXXL delivers the most advanced nitric oxide support available through scientifically validated ingredients that provide powerful, sustained blood flow enhancement.

4. Sugar Free Beet Root Gummies 120-Count — Best Sugar-Free

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These sugar-free nitric oxide gummies feature coconut oil infusion for enhanced absorption while supporting energy and whole-body health.

The strawberry-flavored gummies deliver 60 days of pump support without any added sugar, making them ideal for low-carb and keto dieters. The coconut oil infusion improves the bioavailability of beetroot’s natural nitrates, ensuring your body can efficiently convert them to nitric oxide for maximum blood flow benefits. With 120 gummies per bottle, you’ll get consistent pre-workout nitric oxide support for two full months.

What We Like

• Zero sugar formula perfect for carb-conscious athletes
• Coconut oil infusion enhances nitrate absorption
• 60-day supply offers excellent long-term value

What Could Be Better

• Strawberry flavor may not appeal to everyone
• Not suitable for those with coconut allergies

Bottom Line: These sugar-free beet root gummies deliver effective nitric oxide support with enhanced absorption while fitting perfectly into low-sugar and ketogenic dietary approaches.

5. Original Raw Beet Root Powder 2lb — Best Pure Option

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This cold-pressed beet superfood provides pure, naturally rich plant-based nitrates without additives or fillers.

With a generous 2-pound container, this raw beet root powder offers exceptional value for those who prefer unflavored supplements they can customize. The cold-pressed processing preserves the maximum nitrate content that makes beetroot so effective for enhancing blood flow and workout performance. This non-GMO, vegan, gluten-free powder delivers beetroot in its most natural form, allowing you to add it to pre-workout drinks, smoothies, or any beverage of your choice.

What We Like

• Cold-pressed processing maintains peak nitrate content
• 2-pound container provides months of economical servings
• Unflavored powder offers maximum mixing flexibility

What Could Be Better

• Earthy beet flavor can be strong for some users
• Requires measuring and mixing unlike capsules or gummies

Bottom Line: This pure, cold-pressed beet root powder delivers maximum nitrate content in an economical format perfect for athletes who want unflavored, customizable nitric oxide support.

6. WellPath Beet Root Gummies 1500mg — Best High-Dose

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WellPath delivers 1500mg of concentrated beetroot extract in sugar-free blueberry gummies for powerful nitric oxide elevation.

These super nitric oxide gummies pack a high concentration of beetroot along with antioxidants to support cardiovascular health and pre-workout performance. The blueberry flavor provides a refreshing alternative to typical supplement flavors. With 60 gummies providing a month’s supply, you’ll get concentrated nitric oxide support that helps enhance blood pressure health alongside your workout pumps and endurance.

What We Like

• High 1500mg beetroot dose provides potent nitric oxide boost
• Unique blueberry flavor stands out from competitors
• Supports both cardiovascular health and workout performance

What Could Be Better

• Single month supply requires frequent reordering
• Potency may be excessive for beginners

Bottom Line: WellPath Beet Root Gummies deliver concentrated nitric oxide support with 1500mg of beetroot per serving in a delicious, sugar-free blueberry format for serious athletes.

7. EVL ENGN Shred — Best With Thermogenics

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EVL ENGN Shred combines nitric oxide support with thermogenic fat-burning ingredients and energy for comprehensive pre-workout benefits.

This creatine-free formula delivers lasting energy, focus, and muscle pumps while supporting fat metabolism through its thermogenic blend. The powder mixes easily and provides the caffeine and NO-boosting compounds you need for explosive workouts. If you’re pursuing both performance and body composition goals, this pre-workout offers the nitric oxide benefits for pumps alongside thermogenic support for enhanced calorie burning.

What We Like

• Combines nitric oxide support with thermogenic fat-burning
• Creatine-free formula prevents water retention
• Balanced energy without excessive stimulation

What Could Be Better

• May be too stimulating for evening workouts
• Fruit punch is the only flavor option

Bottom Line: EVL ENGN Shred offers comprehensive pre-workout support by combining nitric oxide boosters with thermogenic ingredients for athletes focused on both performance and fat loss.

8. Odyssey 222 Energy Drink — Best Ready-to-Drink

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Odyssey 222 delivers 222mg of caffeine combined with lion’s mane and cordyceps mushrooms for enhanced energy, focus, and performance.

This sparkling energy drink provides convenient pre-workout nutrition without any mixing required. The combination of substantial caffeine with functional mushrooms creates sustained energy and mental clarity that supports intense training sessions. The pineapple mango flavor is tropical and refreshing, making it easy to consume before workouts. While not a traditional nitric oxide supplement, the circulation-enhancing effects of cordyceps mushrooms complement workout performance.

What We Like

• Zero preparation required—grab and go convenience
• Functional mushrooms provide cognitive and performance benefits
• Delicious tropical flavor masks any supplement taste

What Could Be Better

• High caffeine content may overwhelm sensitive users
• More expensive per serving than powder alternatives

Bottom Line: Odyssey 222 is perfect for those who want convenient pre-workout energy and performance support with functional mushrooms in a delicious, ready-to-drink format.

9. Transparent Labs BULK Black — Best Complete Formula

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Transparent Labs BULK Black delivers clinical doses of 8g citrulline malate and 4g beta-alanine alongside 275mg caffeine for explosive pumps.

This comprehensive pre-workout contains the highest doses of nitric oxide-boosting ingredients you’ll find in a commercial product. The 8 grams of citrulline malate provide maximum vasodilation for intense muscle pumps, while beta-alanine delays fatigue and betaine supports cellular hydration. The formula also includes L-tyrosine and alpha-GPC for cognitive enhancement, creating a complete pre-workout experience that addresses energy, focus, pumps, and endurance simultaneously.

What We Like

• Clinical 8g citrulline dose maximizes nitric oxide production
• Comprehensive formula combines pumps with energy and focus
• Third-party tested for quality assurance and label accuracy

What Could Be Better

• High stimulant content unsuitable for evening training
• Premium pricing reflects comprehensive ingredient profile

Bottom Line: Transparent Labs BULK Black offers the most complete nitric oxide pre-workout by combining clinical doses of pump ingredients with energy, focus, and performance enhancers in one formula.

10. Jacked Factory Nitrosurge Shred — Best Budget

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Nitrosurge Shred combines L-citrulline for nitric oxide production with thermogenic ingredients and caffeine at a budget-friendly price.

This affordable pre-workout includes solid doses of pump-inducing L-citrulline alongside thermogenic compounds to support fat loss goals. The formula provides noticeable vascularity and muscle fullness during workouts while the thermogenic blend helps maximize calorie expenditure. With 30 servings at an accessible price point, this is an excellent entry-level option for those who want nitric oxide benefits without breaking the bank.

What We Like

• Affordable price makes nitric oxide supplementation accessible
• Combines pump support with fat-burning thermogenics
• 30 servings provide a full month of training support

What Could Be Better

• Lower citrulline doses compared to premium options
• Thermogenic effects may not suit those wanting pure pump focus

Bottom Line: Jacked Factory Nitrosurge Shred delivers budget-friendly nitric oxide support combined with thermogenic benefits for athletes pursuing performance and body composition goals simultaneously.

How to Choose the Best Nitric Oxide Pre-Workout

Selecting the right nitric oxide pre-workout starts with understanding which ingredients effectively boost NO production. The gold standard ingredients include L-citrulline (ideally 6-8 grams), beetroot extract or powder rich in dietary nitrates, and newer patented ingredients like Nitrosigine and S7. L-citrulline is particularly effective because it converts to L-arginine in your body, which then produces nitric oxide while avoiding the digestive issues that direct arginine supplementation can cause.

Consider whether you want a standalone nitric oxide booster or a complete pre-workout that includes stimulants. Pure NO supplements are ideal for evening workouts, for those sensitive to caffeine, or for people who want to customize their energy intake separately. Complete pre-workouts combine nitric oxide boosters with caffeine, beta-alanine, and focus enhancers for an all-in-one solution. Many athletes prefer to stack a stimulant-free NO booster with their choice of caffeine source for maximum flexibility and control.

Think about the format that best fits your routine and preferences. Powders typically offer the highest doses of active ingredients and best value per serving, making them ideal for serious athletes who don’t mind mixing. Capsules provide convenience without added sugars and are perfect for travel or quick dosing. Gummies offer palatability and portability, though they may contain sugars and provide lower doses than powders. Ready-to-drink options maximize convenience but usually cost more per serving.

Pay attention to additional performance-enhancing ingredients that complement nitric oxide production. Beta-alanine buffers lactic acid buildup for improved endurance. Betaine anhydrous supports cellular hydration and power output. Electrolytes enhance muscle hydration and support the pumping effect. Some formulas include antioxidants like vitamin C or glutathione that protect nitric oxide from degradation, ensuring it remains bioavailable longer. The best nitric oxide pre-workouts combine multiple pathways to maximize blood flow and performance benefits.

Benefits of Nitric Oxide Pre-Workout

Nitric oxide pre-workouts deliver immediate and noticeable muscle pump benefits that enhance both your workout experience and performance. When blood vessels dilate from increased NO production, more blood flows to working muscles, creating that tight, full feeling lifters crave. This increased blood volume delivers more oxygen and nutrients to muscle tissue exactly when it’s needed most, allowing you to sustain higher training intensity for longer periods. The enhanced nutrient delivery also supports faster recovery between sets and better overall workout performance.

The performance benefits extend beyond just the psychological boost of seeing your muscles pumped. Research shows that ingredients like L-citrulline and beetroot can improve muscular endurance by reducing fatigue and enhancing oxygen delivery to muscle tissue. Studies demonstrate that beetroot supplementation can improve time to exhaustion in high-intensity exercise, while citrulline supplementation has been shown to reduce muscle soreness and improve recovery. These effects allow you to complete more total work during training sessions, which over time translates to better strength and muscle gains.

Cardiovascular health represents another significant benefit of nitric oxide supplementation. NO plays a crucial role in maintaining healthy blood pressure by promoting vasodilation and improving endothelial function—the health of your blood vessel linings. Regular beetroot or citrulline supplementation has been shown in studies to support healthy blood pressure levels and improve markers of cardiovascular function. While you’re taking these supplements for workout performance, you’re simultaneously supporting long-term cardiovascular health through improved circulation and vascular function.

The cognitive benefits of enhanced blood flow shouldn’t be overlooked. Better circulation means improved oxygen and nutrient delivery to your brain, which can enhance mental clarity, focus, and the mind-muscle connection during training. Some nitric oxide pre-workouts include nootropic ingredients that work synergistically with improved blood flow to sharpen mental performance. This combination of physical and cognitive enhancement creates an optimal training state where you’re both physically capable and mentally locked in to maximize every rep and set.

Frequently Asked Questions

How long before my workout should I take nitric oxide supplements?

Take nitric oxide supplements 30-60 minutes before training for optimal effects. Beetroot-based supplements work best when taken 60-90 minutes pre-workout because your body needs time to convert dietary nitrates into nitric oxide. Citrulline-based products typically peak around 30-45 minutes after consumption. Some athletes take NO supplements daily for consistent cardiovascular benefits regardless of workout timing.

Can I take nitric oxide supplements on rest days?

Yes, many people take nitric oxide supplements daily for continuous cardiovascular health benefits. While you’ll notice the muscle pump effects most during training, the circulation and blood flow benefits occur throughout the day. Daily supplementation with beetroot or citrulline may help maintain healthy blood pressure and support overall vascular function even on days you don’t exercise.

Do nitric oxide pre-workouts really work or is it just marketing?

Clinical research confirms that key nitric oxide-boosting ingredients are effective. Studies show that L-citrulline significantly increases nitric oxide production and improves exercise performance. Beetroot supplementation has been demonstrated to enhance endurance exercise capacity and reduce oxygen cost during physical activity. The pump and performance benefits are real physiological responses, not just placebo effects.

Can I stack nitric oxide supplements with regular pre-workout?

Absolutely—stacking a stimulant-free NO booster with a caffeinated pre-workout is a popular and effective strategy. This allows you to maximize pump benefits while customizing your energy and stimulant intake. Just ensure you’re not doubling up on ingredients and exceeding recommended doses. Check if your pre-workout already contains citrulline or beetroot before adding additional NO supplements.

Will nitric oxide supplements lower my blood pressure too much?

For most healthy individuals, nitric oxide supplements support healthy blood pressure levels without causing problematic drops. However, if you’re already taking blood pressure medications or have hypotension, consult your doctor before using NO supplements. The blood pressure effects are typically modest and beneficial, but medical supervision is appropriate if you have existing cardiovascular conditions or take related medications.

What’s better for pumps: L-citrulline or beetroot?

Both are effective but work through different mechanisms. L-citrulline converts to L-arginine and then to nitric oxide through the NOS pathway, while beetroot provides dietary nitrates that convert to NO through the nitrate-nitrite-NO pathway. Research suggests they may work synergistically when combined. Many advanced formulas include both to maximize NO production through multiple pathways for superior pumps.

How long do the pump effects last after taking NO supplements?

The acute muscle pump from increased blood flow typically lasts 30-60 minutes after finishing your workout, though this varies individually. Advanced ingredients like Nitrosigine may provide sustained nitric oxide elevation for several hours. The cardiovascular benefits of regular NO supplementation are longer-lasting and accumulate with consistent daily use over weeks and months.

Do I need to cycle nitric oxide supplements?

No cycling is necessary for most nitric oxide supplements. Ingredients like L-citrulline and beetroot can be taken continuously without diminishing returns. Unlike some supplements where your body builds tolerance, NO boosters maintain their effectiveness with regular use. In fact, some research suggests that chronic beetroot supplementation may provide additional cumulative cardiovascular benefits compared to acute supplementation.

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