Best Omega-3 for Heart Health (2026) – Top 10 Reviewed
Omega-3 fatty acids are essential nutrients that play a vital role in cardiovascular wellness, helping support healthy heart rhythm, blood pressure, and triglyceride levels already within the normal range. If you’re looking to boost your heart health naturally, high-quality omega-3 supplements offer a convenient way to ensure optimal intake of these beneficial fats. This guide reviews the best omega-3 supplements specifically chosen for their heart-supporting properties, helping you find the right formula for your cardiovascular needs.
Our Top Picks at a Glance
- Best Overall: Designs for Health OmegAvail Hi-Po — professional-grade with 1600mg EPA/DHA
- Best Value: Luma Nutrition Omega-3 2500mg — extra strength formula with high potency
- Best Premium: Metagenics OmegaGenics EPA 1200 — pharmaceutical-grade purity
Quick Comparison
| Product | Key Ingredients | Form | Servings | Best For |
|---|---|---|---|---|
| Designs for Health OmegAvail Hi-Po | 1600mg EPA/DHA triglyceride form | Softgels | 60 | Overall use |
| Luma Nutrition Omega-3 2500mg | 2000mg EPA & DHA | Softgels | 120 | Value seekers |
| Metagenics OmegaGenics EPA 1200 | 1200mg EPA per serving | Softgels | 120 | Premium quality |
| Triple Strength Omega-3 2500mg | 2500mg re-esterified TG form | Softgels | 180 | High potency |
| Natural Force Pure Omega-3 Liquid | Liquid fish oil, lemon cake flavor | Liquid | 48 | Liquid preference |
| NATURE TARGET Omega-3 1600mg | EPA/DHA with PS & CoQ10 | Softgels | 120 | Multi-nutrient support |
| 1MD Nutrition KrillMD | Antarctic krill oil with astaxanthin | Softgels | 60 | Krill oil option |
| ScienceBased Health HydroEye | GLA & omega-3 complex | Softgels | 60 | Eye & heart health |
1. Designs for Health OmegAvail Hi-Po — Best Overall
- High Concentration, Multi-Form Fish Oils - BioGlycerides uniquely combines three different forms of fish oils for improved bioavailability and distribution to tissues. Contains 1600mg of EPA/DHA combined per serving in a 1:1 ratio.
- Sustainable Sourcing - Sourced from sustainable wild-caught anchovy, sardine, and mackerel fish from Peru and Chile.
- Digestibility Support & Minimizing Fishy Aftertaste - The addition of lipase makes it easier for your body to digest and absorb the fish oils and to help avoid a fishy aftertaste.
- Purity Assurance - The fish oil undergoes molecular distillation and filtration, ensuring it’s pure and free from pesticides, PCBs, and other contaminants.
- Clinically-Trusted Care - DFH is the #1 practitioner supplement brand recommended by functional medicine professionals and the #1 practitioner supplement brand personally trusted by functional medicine professionals.**
This professional-grade omega-3 supplement delivers 1,600mg of EPA and DHA per serving in the highly absorbable triglyceride form.
Designs for Health uses the TruTG™ form of omega-3s, which mirrors the natural triglyceride structure found in fish for superior absorption and bioavailability. Each serving provides concentrated EPA and DHA from purified fish oil, molecularly distilled to remove contaminants. The formula is tested for heavy metals, PCBs, and other environmental toxins to ensure pharmaceutical-grade purity.
What We Like
- Superior triglyceride form for better absorption
- Professional-grade quality with rigorous testing
- High concentration reduces pill burden
What Could Be Better
- Premium pricing reflects professional quality
- Larger softgel size due to high potency
Bottom Line: A top-tier choice for those seeking maximum absorption and pharmaceutical-grade purity in their omega-3 supplement.
2. Luma Nutrition Omega-3 2500mg — Best Value
- Best Omega 3 Supplement: Luma Nutrition's fish oil omega 3 supplements are premium quality with an extra strength dosage. Omega 3 fish oil with 2000mg of high quality EPA & DHA Omega 3 fatty acids, all in a softgel capsule to enhance absorption for maximum benefits.
- High EPA Fish Oil: Our product is a high epa omega 3 fish oil supplement, containing 2500 mg of fish oil, far exceeding competitor's fish oil 1200 mg servings. This omega 3 fatty acid supplement is perfect for heart circulation and brain health, supports a healthy immune system, and contributes to radiant skin and hair.
- Myriad of Health Benefits: Omega-3 fatty acids are vital to maintain healthy cardiovascular and eye function. Omega 3 fish oil supports cognitive function, improving memory, focus, and overall brain health. In addition, its overall calming properties on the body can alleviate joint stiffness, enhancing long term mobility and flexibility in aging adults.
- 30 Day Supply: Each bottle of Luma Nutrition's burpless fish oil pills last for a month to maintain optimal freshness and provide strong daily support straight from nature. This all natural cardiovascular and joint support supplement makes the perfect monthly subscription for men and women. Stay in stock and save money at the same time!
- Made in the USA by Veteran-Owned Small Business: Trust in Luma Nutrition's GMP certified, USA-manufactured supplements that are 3rd party verified. As a veteran-owned brand, we prioritize quality and expert craftsmanship to assist with your health journey.
This extra-strength formula delivers an impressive 2,000mg of EPA and DHA combined in each serving, offering exceptional potency at an attractive price point.
Luma Nutrition provides 2,500mg of total fish oil with 2,000mg of combined EPA and DHA per serving. The concentrated formula is molecularly distilled and third-party tested for purity. Each bottle contains 120 softgels, providing a 60-day supply when taking the recommended two softgels daily for cardiovascular support.
What We Like
- Very high EPA and DHA content per serving
- Excellent value for the potency provided
- Third-party tested for purity and quality
What Could Be Better
- May have mild fishy aftertaste for some users
- Larger softgels due to high concentration
Bottom Line: An outstanding value for those seeking high-potency omega-3s without the premium price tag.
3. Metagenics OmegaGenics EPA 1200 — Best Premium
- Provides 1200 mg of EPA per serving in a high-potency, pharmaceutical-grade fish oil to support cardiovascular function, healthy triglyceride levels, and immune system health*
- Made from sustainably sourced, wild-caught cold-water fish with a burpless, enteric-coated formula for optimal absorption and no fishy aftertaste*
- Third-party tested for over 200 contaminants to ensure exceptional purity, potency, and freshness—backed by rigorous quality standards and clinical research*
- Produced in a cGMP-certified facility and Certified B Corporation; trusted by healthcare practitioners for over 40 years for safety, transparency, and results*
Metagenics delivers pharmaceutical-grade omega-3s with a concentrated 1,200mg of EPA per serving for targeted cardiovascular support.
This formula emphasizes EPA, which research particularly links to heart health benefits including supporting healthy triglyceride levels and cardiovascular function. The fish oil is sustainably sourced and undergoes multiple purification steps to achieve pharmaceutical-grade quality. Metagenics uses an enteric coating to minimize fishy burps and improve tolerability.
What We Like
- Concentrated EPA for targeted heart support
- Pharmaceutical-grade quality and purity
- Enteric coating reduces fishy aftertaste
What Could Be Better
- Higher price reflects premium quality standards
- Lower DHA content than balanced formulas
Bottom Line: An excellent premium choice for those specifically seeking high-EPA omega-3s for cardiovascular wellness.
4. Triple Strength Omega-3 2500mg — Best High Potency
- Triple strength omega-3 fish oil - Our fish oil for men and women delivers a high-potency dose of omega-3 with each serving providing 2,500 mg of fish oil, including 1,500 mg EPA, 570 mg DHA and 50 mg DPA
- Omega-3 for heart, brain, skin & eye health* - Science has shown that not only do the omega-3s in fish oil offer cardiovascular support for men and women, but they also support brain health, skin and eye health*
- Purified to reduce mercury - Using a combination of fish (sardines, anchovies and mackerel), our fish oil is purified to reduce PCBs, dioxins, furans and mercury to ensure levels are below IFOS set limits of ≤45 ppb, ≤ 1 ppt and ≤ 0.1 ppm respectively
- For greater absorption - The omega-3 fatty acids in our fish oil capsules are delivered in re-esterified triglyceride form. Triglycerides have been shown to be more easily absorbed by your body
- Quality you can trust - Made with wild caught fish using sustainable fishing practices. Our fish oil softgels are IFOS Certified and Labdoor Certified for quality, purity and potency, and are also gluten-free, non-GMO and pescatarian-friendly
This maximum-strength formula provides omega-3s in the re-esterified triglyceride form for enhanced absorption and bioavailability.
The re-esterified triglyceride form offers superior absorption compared to standard ethyl ester fish oils, ensuring your body can effectively utilize the EPA and DHA. Each serving delivers 2,500mg of concentrated omega-3s with high levels of EPA, DHA, and DPA. The formula is molecularly distilled and tested for purity and contaminants.
What We Like
- Re-esterified TG form for better absorption
- Includes beneficial DPA alongside EPA and DHA
- Large 180-count bottle for extended supply
What Could Be Better
- Requires multiple softgels per serving
- Premium form comes with higher price
Bottom Line: An excellent option for those who want maximum potency in the most absorbable triglyceride form available.
5. Natural Force Pure Omega-3 Liquid — Best Liquid Formula
- Concentrated Liquid Lemon Fish Oil - Get the benefits of omega 3s without the discomfort of hard to swallow capsules. Just one teaspoon of Pure Omega-3 provides 1,326mg of pure, concentrated EPA, DHA, and DPA omega 3s in a highly bioavailable natural triglyceride form
- Marine Stewardship Council Certified & Keto, Paleo, Kosher, and Halal – Natural Force Pure Omega-3 is sourced from a Marine Stewardship Council certified sustainable fishery. And, with all natural ingredients like rosemary extract, monk fruit, and zero sugar, it is also certified Keto, Paleo Friendly, Kosher, and Halal
- Mercury Free and Lab Tested for Purity, Potency, and Quality - Ultra purified, molecularly filtered, and sustainably sourced from wild caught menhaden fish, Pure Omega-3 is lab tested to ensure every batch is free of mercury, dioxins, PCBs, and gluten. We freely share the results of our testing because we have nothing to hide!
- Delicious Lemon Cake Flavor - Pure Omega-3 has a delicious lemon cake flavor that makes it perfect for smoothies, shakes, or straight off the spoon. Plus, it comes packaged in a UV light blocking amber glass bottle that preserves freshness and flavor
- Nutrition You Can Trust - Natural Force values the health and happiness of our customers. If you have any questions, comments, or concerns, send us a message from your Amazon account and our world-class Customer Support team will help to make it right
This liquid fish oil features a delicious lemon cake flavor while providing concentrated omega-3s from wild-caught, mercury-free fish.
Natural Force sources their fish oil from wild-caught fish in pristine waters and uses molecular distillation to remove mercury and other contaminants. The pleasant lemon cake flavor makes it easy to take directly or mix into smoothies and beverages. Liquid form allows for flexible dosing and may be easier to swallow than large softgels.
What We Like
- Delicious lemon cake flavor masks fish taste
- Liquid form easier to swallow than capsules
- Wild-caught, mercury-free fish source
What Could Be Better
- Requires refrigeration after opening
- Less convenient for travel than capsules
Bottom Line: Perfect for those who prefer liquid supplements or have difficulty swallowing pills while still wanting high-quality omega-3s.
6. NATURE TARGET Omega-3 1600mg — Best Multi-Nutrient Formula
- Targeted Cognitive Support : Enriched with the key brain nutrient Phosphatidylserine (PS) that works synergistically with DHA to maintain cell membrane fluidity and neurotransmitter release, enhancing memory and concentration. Ideal for those under work stress and older adults.
- Fuel Your Brain, Power Your Day : Coenzyme Q10 supports mitochondrial ATP production, converting nutrients into energy. Helps reduce mental fatigue, boost clarity, and improve productivity—perfect for professionals and frequent mental workers to stay energized all day.
- Higher Purity, Better Absorption : Sourced from small deep-sea fish, rich in DHA and EPA for high absorption. Essential for supporting brain function and cognitive health. Regular supplementation helps improve memory, focus, and overall mental clarity.
- No Fishy Aftertaste Or Burps : Employing advanced purification techniques to remove mercury and heavy metals, and encapsulating the fish oil in a special enteric coating, this formula ensures purity and safety. It prevents the fish oil from breaking down in the stomach, thereby avoiding fishy aftertaste or burping and reducing gastric discomfort.
- Commitment To Quality : We are committed to quality safety and production compliance. All products have undergone third-party testing and are produced in accordance with cGMP standards. NATURE TARGET Fish Oil Omega 3 is a non-genetically modified product, free of gluten, soy, and artificial additives, ensuring its purity and safety.
This comprehensive formula combines 1,600mg of omega-3s with phosphatidylserine and CoQ10 for synergistic heart and brain support.
NATURE TARGET enhances their high-purity fish oil with phosphatidylserine (PS) for cognitive function and CoQ10 for cellular energy and cardiovascular health. The omega-3s provide EPA and DHA for heart health, while the additional nutrients create a complete cardiovascular and brain wellness formula. All ingredients are combined in easy-to-swallow softgels.
What We Like
- Combines omega-3s with complementary nutrients
- Supports both heart and brain health
- High-purity fish oil base
What Could Be Better
- More expensive due to multiple ingredients
- May duplicate nutrients if taking other supplements
Bottom Line: An intelligent choice for those seeking omega-3s plus additional heart and brain-supporting nutrients in one formula.
7. 1MD Nutrition KrillMD — Best Krill Oil Option
- 2x More Effective Than Fish Oil: KrillMD is made from sustainably-sourced Antarctic krill oil. This pure source of omega-3 fatty acids is clinically-studied to be more effective than fish oil, without the fishy aftertaste.*
- Efficient Joint Support: Krill phospholipids bind to omega-3s to maximize efficient absorption so your joints get the support they need. Feel an easier time moving around thanks to more flexible joints, and reduced soreness. *
- Powerful Antioxidant Activity: KrillMD contains astaxanthin, a powerful antioxidant that works to reduce common types of oxidative stress in the body for optimal joint, heart, and brain health.*
- Long-Term Heart Health: EPA, the highly potent omega-3 in krill oil, helps maintain normal cholesterol levels. The combination with the antioxidant benefits of astaxanthin helps you support heart health now and later.*
- Brain Health Support: Another powerful omega-3 fatty acid, DHA, helps support proper brain function. With regular supplementation, studies have found that krill oil helps promote memory, mood, and cognitive function.*
This Antarctic krill oil provides omega-3s in phospholipid form with natural astaxanthin for enhanced absorption and antioxidant benefits.
1MD Nutrition sources premium Antarctic krill oil that contains EPA and DHA bound to phospholipids, which research suggests may be more readily absorbed than fish oil triglycerides. The formula includes astaxanthin, a powerful antioxidant that gives krill oil its distinctive red color and provides additional cardiovascular protection. The smaller softgels are easier to swallow and have minimal fishy aftertaste.
What We Like
- Phospholipid-bound omega-3s for superior absorption
- Natural astaxanthin provides antioxidant benefits
- Smaller, easier-to-swallow softgels
What Could Be Better
- More expensive per milligram than fish oil
- Not suitable for shellfish allergies
Bottom Line: An excellent alternative to fish oil for those seeking enhanced absorption and the unique benefits of krill oil.
8. ScienceBased Health HydroEye — Best for Eye & Heart Health
- WORKS FROM THE INSIDE OUT: Nourishes the eye to support all three layers of the tear film
- CLINICALLY Tested: Shown to promote eye comfort and support a healthy ocular surface in a peer-reviewed clinical trial published in Cornea
- PROPRIETARY, BALANCED FORMULA: Precise blend of GLA, omega-3 EPA & DHA, and other key nutrients work together to help soothe dry eyes and support visual health
- FEATURES GLA – THE DRY EYE OMEGA: Provides a unique source of GLA from black currant seed oil—not found in fish or flaxseed oils—supported by multiple clinical studies for its role in dry eye
- FOR BEST RESULTS: Take four softgels daily; allow 30–60 days of consistent use to experience the full benefit, and continue daily for ongoing support
This clinically tested formula combines GLA with omega-3s to support both cardiovascular wellness and eye health.
HydroEye provides a unique blend of gamma-linolenic acid (GLA) from black currant seed oil and omega-3 fatty acids in a formula specifically designed to support dry eye conditions while also benefiting cardiovascular health. The comprehensive essential fatty acid profile includes EPA, DHA, and GLA working synergistically for overall wellness.
What We Like
- Clinically tested formula for dry eye support
- Combines multiple beneficial fatty acids
- Supports both eye and heart health
What Could Be Better
- Lower EPA/DHA concentration than pure fish oils
- Specialized formula may be more than some need
Bottom Line: An intelligent choice for those seeking omega-3s for heart health who also want targeted support for dry eye conditions.
How to Choose the Best Omega-3 for Heart Health
The EPA and DHA content is the most critical factor when selecting an omega-3 supplement for heart health. Look for supplements that clearly list the amounts of EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid) on the label, not just total omega-3 or fish oil content. For cardiovascular benefits, research suggests a combined intake of 1,000-2,000mg of EPA and DHA daily, with many cardiologists recommending higher EPA concentrations specifically for heart health support.
The molecular form significantly impacts absorption and effectiveness. Omega-3s come in three main forms: natural triglycerides (found in whole fish), ethyl esters (common in many supplements), and re-esterified triglycerides. Natural and re-esterified triglyceride forms generally offer superior absorption compared to ethyl esters. Some premium supplements use phospholipid-bound omega-3s from krill, which may enhance bioavailability even further. Check the supplement facts panel to determine which form your product contains.
Purity testing is essential for omega-3 supplements since fish can accumulate environmental contaminants. Look for products that are molecularly distilled or undergo similar purification processes to remove mercury, PCBs, dioxins, and other toxins. Third-party certifications from organizations like IFOS (International Fish Oil Standards) or USP (United States Pharmacopeia) provide additional assurance of purity and potency. These certifications verify that the product contains what the label claims without harmful contaminants.
Freshness matters significantly with omega-3 supplements because these delicate fats can oxidize over time, reducing effectiveness and creating an unpleasant fishy taste. Check for added antioxidants like vitamin E or astaxanthin that protect against oxidation. Some products include a “totox” value (total oxidation value) on the label—lower numbers indicate fresher oil. Enteric-coated softgels or liquid formulas with natural flavors can minimize fishy burps while ensuring the omega-3s reach your intestines for optimal absorption.
Consider the sustainability and source of the fish oil. Wild-caught fish from pristine waters like Alaska, Norway, or Peru typically provide cleaner oil than farm-raised sources. Look for certifications from organizations like MSC (Marine Stewardship Council) or Friend of the Sea that verify sustainable fishing practices. Small fish like anchovies, sardines, and mackerel tend to have lower contaminant levels than larger predatory fish.
Benefits of Omega-3 for Heart Health
Omega-3 fatty acids provide multiple cardiovascular benefits through various mechanisms. EPA and DHA help reduce triglyceride levels in the blood, with research showing reductions of 15-30% at therapeutic doses. Lower triglycerides contribute to better overall cholesterol profiles and reduced cardiovascular risk. The American Heart Association recognizes omega-3s for their ability to support healthy triglyceride levels already within the normal range.
These essential fats support healthy blood pressure levels through multiple pathways. Omega-3s help blood vessels relax and dilate properly, improving blood flow and reducing resistance in the arteries. They also influence the production of substances that regulate blood pressure, contributing to cardiovascular homeostasis. Research indicates that regular omega-3 intake of 2-3 grams daily can support healthy blood pressure in individuals with normal levels.
Omega-3s play a crucial role in maintaining normal heart rhythm by stabilizing cardiac cell membranes and influencing electrical activity in the heart. This electrophysiological effect helps support healthy heart rhythm patterns. The anti-inflammatory properties of EPA and DHA also benefit cardiovascular health by helping moderate the inflammatory processes involved in atherosclerosis and other cardiovascular conditions.
Beyond direct cardiovascular effects, omega-3s provide systemic benefits that support overall heart health. They help maintain healthy platelet function, supporting appropriate blood clotting responses. The essential fatty acids also support endothelial function—the health of the inner lining of blood vessels—which is crucial for vascular flexibility and responsiveness. These comprehensive effects make omega-3 supplementation a cornerstone of natural cardiovascular wellness strategies.
Frequently Asked Questions
How much omega-3 should I take for heart health?
For general cardiovascular wellness, most experts recommend 1,000-2,000mg of combined EPA and DHA daily. Those with elevated triglycerides may benefit from higher doses of 2,000-4,000mg under medical supervision. The American Heart Association recommends at least two servings of fatty fish weekly, which provides approximately 500mg of EPA and DHA daily. Supplements can help bridge the gap if you don’t regularly eat fish.
When should I take omega-3 supplements?
Take omega-3 supplements with meals containing some fat, as dietary fat enhances absorption of these fat-soluble nutrients. Many people prefer taking them with their largest meal of the day to minimize any fishy aftertaste. Splitting your dose between morning and evening can help maintain steady blood levels and may reduce digestive discomfort for some individuals.
Can I take omega-3 with blood thinners?
Omega-3 supplements can affect blood clotting, so you must consult your healthcare provider before combining them with anticoagulant or antiplatelet medications like warfarin, aspirin, or clopidogrel. While omega-3s and these medications can often be used together, your doctor may need to adjust dosages or monitor you more closely. Never start omega-3 supplementation without medical guidance if you’re taking blood thinners.
What’s the difference between fish oil and krill oil?
Both provide omega-3s (EPA and DHA), but krill oil contains them bound to phospholipids while fish oil typically uses triglycerides. Some research suggests phospholipid-bound omega-3s from krill may be better absorbed. Krill oil also contains astaxanthin, a beneficial antioxidant. However, fish oil generally provides more EPA and DHA per dollar and has more extensive research supporting its cardiovascular benefits.
Do omega-3 supplements have side effects?
Omega-3 supplements are generally well-tolerated. Common side effects include fishy burps, mild nausea, or digestive upset, especially at higher doses. Taking supplements with food or choosing enteric-coated versions can minimize these effects. Rare side effects may include loose stools or an increased tendency to bruise. Very high doses may affect blood clotting, which is why medical supervision is recommended for doses above 3 grams daily.
How long does it take to see benefits from omega-3 supplements?
Omega-3 benefits accumulate over time. Triglyceride reductions can be measurable within 2-4 weeks, while blood pressure effects may take 6-8 weeks of consistent supplementation. Anti-inflammatory benefits and improvements in endothelial function typically require 8-12 weeks to become apparent. Consistent daily intake is key—omega-3s work best as part of a long-term cardiovascular wellness strategy rather than a quick fix.
Should I take omega-3 if I eat fish regularly?
If you consume fatty fish like salmon, mackerel, or sardines 2-3 times weekly, you may be getting adequate omega-3s from diet alone. However, many people don’t maintain this frequency consistently. A blood test measuring omega-3 index can determine if supplementation would benefit you. Your healthcare provider can help evaluate whether your dietary intake meets your individual needs based on your cardiovascular risk factors.
Can omega-3 supplements go rancid?
Yes, omega-3s can oxidize and go rancid if not stored properly. Store supplements in a cool, dark place or refrigerate them after opening to slow oxidation. Check the expiration date and discard any supplements that smell strongly fishy or rancid. Quality products include antioxidants like vitamin E to extend shelf life. Following storage recommendations and using products before expiration helps ensure you get fresh, effective omega-3s.
