Best Ox Bile Supplements (2026) – Top 10 Reviewed
Ox bile supplements provide concentrated bile salts to support fat digestion, particularly for people who’ve had their gallbladder removed or those with digestive challenges. These supplements help your body break down dietary fats and absorb fat-soluble vitamins. This guide covers the top ox bile products available to help you find the right digestive support supplement.
Our Top Picks at a Glance
- Best Overall: Double Wood Ox Bile — standardized to 45% cholic acid bile salts
- Best Value: Horbäach Ox Bile — high potency 1000mg per serving
- Best for Flexibility: NutriCology Ox Bile 125mg — adjustable dosing options
Quick Comparison
| Product | Dosage | Form | Servings | Best For |
|---|---|---|---|---|
| Double Wood Ox Bile | 1000mg (45% cholic acid) | Capsules | 60 | Post-gallbladder removal |
| Horbäach Ox Bile | 1000mg | Capsules | 50 | High-dose needs |
| NutriCology Ox Bile 125mg | 125mg | Capsules | 180 | Flexible dosing |
| NutriCology Ox Bile 500mg | 500mg | Capsules | 180 | Moderate support |
| Primal Ox Bile | 500mg | Capsules | 120 | Third-party tested quality |
| Dr. Berg Gallbladder Formula | Complex formula | Vegetable capsules | 45 | Comprehensive support |
| Therexa Gallbladder Formula | Complex with enzymes | Vegetable capsules | 90 | Complete digestive blend |
1. Double Wood Ox Bile — Best Overall
- OX BILE SUPPLEMENTS FOR NO GALLBLADDER: When you have lost your gallbladder, a lack of bile can lead to indigestion, bloating, fatigue, and other symptoms after meals. An Ox Bile supplement standardized to contain bile salts, such as cholic acid, may help people who no longer have their gallbladder
- STANDARDIZED TO 45% CHOLIC ACID BILE SALTS: It is important to choose an Ox Bile supplement standardized to contain cholic acid bile salts, as these are the active ingredient in Ox Bile that helps provide gallbladder support
- OX BILE SUPPLEMENTS WITH LITTLE TO NO BILE SALTS HAVE MINIMAL EFFECT: The purpose of an Ox Bile supplement is to help replenish your body's levels of bile salts. It is crucial to choose an Ox Bile supplement standardized to contain bile salts like cholic acid
- TWO-MONTH SUPPLY: Double Wood provides 60 servings of 1,000 mg Ox Bile (120 capsules of 500 mg), enough to last a full two months
- WE BOTTLE WELLNESS: At Double Wood we provide pure, potent supplements that deliver exceptional value, all backed by careful sourcing and rigorous third-party testing
Double Wood delivers the gold standard for ox bile supplementation with standardized bile salt content.
This supplement provides 1000mg of ox bile per serving, standardized to contain 45% cholic acid bile salts — the active compounds that actually support fat digestion. Unlike generic ox bile products, Double Wood ensures you’re getting therapeutic levels of the bile salts your body needs. Each bottle contains 120 capsules (500mg each), providing a two-month supply for consistent digestive support.
What We Like
- Standardized to 45% cholic acid for reliable potency
- Two-month supply at 1000mg daily dosing
- No fillers, manufactured in USA
- Third-party tested for quality
What Could Be Better
- Requires two capsules per serving
- May have slight odor
Bottom Line: The standardized bile salt content makes Double Wood the most reliable choice for those needing consistent digestive support, especially after gallbladder removal.
2. Horbäach Ox Bile — Best Value
- ABOUT OX BILE: A fluid produced by the liver that helps support your daily routine
- ADVANCED OX BILE: Features 1,000 mg Ox Bile per serving in quick-release capsules for maximum support
- PROFESSIONALLY CRAFTED: Our supplements use advanced sourcing to ensure purity and potency always
- NATURALLY FREE OF: Gluten, Wheat, Yeast, Milk, Soy, Artificial Color & Flavor & Non-GMO
Horbäach delivers professional-grade ox bile supplementation at an accessible price point.
This formula provides 1000mg of ox bile per serving in quick-release capsules designed for maximum absorption. The supplement is manufactured by a company with over 40 years in the natural products industry, using advanced sourcing to ensure purity. Each bottle contains 100 capsules with no artificial colors, flavors, or GMO ingredients.
What We Like
- High potency 1000mg per serving
- Quick-release capsules for better absorption
- Gluten-free, non-GMO formula
- Excellent value for the potency
What Could Be Better
- Not standardized to specific bile salt percentage
- Contains rice powder as filler
Bottom Line: A budget-friendly option that delivers therapeutic doses of ox bile without unnecessary additives.
3. NutriCology Ox Bile 125mg — Best for Flexibility
- Fat Digestion Support: NutriCology Ox Bile 125 mg provides concentrated bile salts to support normal fat digestion and daily digestive wellness*
- Nutrient Absorption: Supports natural absorption of fat-soluble vitamins and healthy intestinal motility for overall digestive function*
- Concentrated Bile Salts: Delivers bovine bile to complement the body’s own bile production and support dietary fat breakdown*
- Highest Purity Standards: This supplement is free from gluten, dairy, soy, corn, nuts, egg, shellfish, fish, sesame and yeast
- Solutions Backed by Science: Allergy Research Group and its family of brands—Metabolic Maintenance, MethylPro, Nutricology and Optimox—have delivered trusted supplements for more than 45 years
NutriCology’s lower-dose option allows precise control over your ox bile intake.
This 125mg formulation provides concentrated bile salts in a dosage that can be easily adjusted to your individual needs. The lower strength per capsule makes it ideal for those who need to titrate their dose based on meal composition or digestive response. With 180 capsules per bottle, you get excellent value and long-term supply flexibility.
What We Like
- Perfect for dose customization
- 180 servings per bottle
- Hypoallergenic and vegetarian capsules
- Free from all major allergens
- Small capsule size for easy swallowing
What Could Be Better
- May require multiple capsules for higher doses
- More expensive per mg than higher-dose options
Bottom Line: The adjustable dosing makes this ideal for those who want precise control or are starting ox bile supplementation.
4. NutriCology Ox Bile 500mg — Best Moderate Dose
- Fat Digestion Support: NutriCology Ox Bile 500 mg provides concentrated bile salts to support normal fat digestion and daily digestive wellness*
- Nutrient Absorption: Supports natural absorption of fat-soluble vitamins and healthy intestinal motility for overall digestive function*
- Concentrated Bile Salts: Delivers bovine bile to complement the body’s own bile production and support dietary fat breakdown*
- Highest Purity Standards: This supplement is free from gluten, dairy, soy, corn, nuts, egg, shellfish, fish, sesame and yeast
- Solutions Backed by Science: Allergy Research Group and its family of brands—Metabolic Maintenance, MethylPro, Nutricology and Optimox—have delivered trusted supplements for more than 45 years
The 500mg strength offers a balanced middle ground for most digestive support needs.
This formulation delivers moderate-strength ox bile that supports fat digestion without overwhelming your system. The concentrated bile salts help break down dietary fats and improve absorption of vitamins A, D, E, and K. With 180 capsules, this bottle provides excellent long-term value for consistent daily supplementation.
What We Like
- Balanced 500mg dose works for most people
- 180 servings for long-term use
- Highest purity standards
- Over 45 years of supplement expertise
What Could Be Better
- Mid-range pricing
- May need multiple capsules for higher needs
Bottom Line: A reliable moderate-dose option from a trusted brand with exceptional purity standards.
5. Primal Ox Bile — Best Third-Party Tested
- Digestive Support: Primal's Ox Bile Capsules offer support for your digestive system, helping you empower your health.
- Generous Supply: With 120 capsules per bottle, this supplement provides an ample and convenient supply, allowing consistent integration into your daily health routine.
- 500mg Per Serving: Each serving contains 500mg of ox bile, delivering a standardized amount for those looking to incorporate this component into their wellness regimen.
- Manufacturing Excellence: Crafted in an NSF Certified GMP Compliant facility, Primal's commitment to quality is evident in every capsule, meeting the highest industry standards.
- Third-Party Validation: Rigorous third-party testing by independent ISO-accredited laboratories ensures the purity and quality of each batch, offering peace of mind to both gym-goers and health-conscious individuals. Elevate your digestive wellness with Primal's Ox Bile Capsules.
Primal ensures quality through rigorous independent laboratory testing.
This supplement provides 500mg of ox bile per serving, manufactured in an NSF Certified GMP Compliant facility. Every batch undergoes third-party testing by independent ISO-accredited laboratories, giving you extra confidence in product quality and purity. The 120-capsule bottle provides a four-month supply at the recommended single-capsule daily dose.
What We Like
- Rigorous third-party testing
- NSF Certified GMP facility
- 120 servings per bottle
- Clean formula without unnecessary additives
What Could Be Better
- Single-capsule serving may not be enough for some
- Premium price for the quality assurance
Bottom Line: The extra quality verification makes this worth considering if you prioritize independently tested supplements.
6. Dr. Berg Gallbladder Formula — Best Comprehensive Formula
- 𝗢𝗥𝗜𝗚𝗜𝗡𝗔𝗟 𝗚𝗔𝗟𝗟𝗕𝗟𝗔𝗗𝗗𝗘𝗥 𝗦𝗨𝗣𝗣𝗟𝗘𝗠𝗘𝗡𝗧 – This gallbladder formula is made with ox bile powder, conjugated bile acid, and a proprietary blend of digestive enzymes. Recommended 2 capsules per day with a meal. Includes 90 capsules (45-day supply).
- 𝗨𝗦𝗔 𝗚𝗠𝗣 𝗖𝗘𝗥𝗧𝗜𝗙𝗜𝗘𝗗 𝗠𝗔𝗡𝗨𝗙𝗔𝗖𝗧𝗨𝗥𝗜𝗡𝗚 - Our state-of-the-art manufacturing facilities are located in the US and are staffed with highly trained individuals who formulate superior products. Being certified under US laws and regulations (GMP Certified), these facilities are uncompromising when it comes to cleanliness and quality control.
- 𝗜𝗡𝗖𝗥𝗘𝗗𝗜𝗕𝗟𝗘 𝗜𝗡𝗚𝗥𝗘𝗗𝗜𝗘𝗡𝗧𝗦 - We're sorry to say it, but if you’re looking for cheap, you’re in the wrong place. We search far and wide, domestic and international, to provide high-quality ingredients for which your body will thank you. Unfortunately, getting the best ingredients from domestic and international farms can come at a higher-than-normal cost. If quality, satisfaction, and results are essential to you, you’re in the right place!
- 𝗪𝗛𝗬 𝗪𝗘’𝗥𝗘 𝗗𝗜𝗙𝗙𝗘𝗥𝗘𝗡𝗧 - Also known as The Knowledge Doc, Dr. Berg has spent most of his life researching and providing natural solutions to everyday health problems. This extensive research and thousands of hours working with patients are what sets us apart from other brands, as it has allowed us to create proprietary blends you can’t get anywhere else.
- 𝟯𝟬-𝗗𝗔𝗬 𝗚𝘂𝗮𝗿𝗮𝗻𝘁𝗲𝗲 - If for any reason you're not happy with the results you experience within the first 30 days, we're happy to give you a full refund! Send us a message, and the refund will be processed as long as it's requested within 30 days of purchase.
Dr. Berg’s formula combines ox bile with complementary digestive support ingredients.
This extra-strength formula includes ox bile powder, conjugated bile acid, and a proprietary digestive enzyme blend. Additional ingredients like choline, stoneroot, and slippery elm provide comprehensive gallbladder and liver support. The formula is designed to work synergistically, addressing multiple aspects of fat digestion and bile flow.
What We Like
- Comprehensive formula with multiple active ingredients
- Includes conjugated bile acids
- USA GMP certified manufacturing
- Vegetable capsules
What Could Be Better
- Proprietary blend doesn’t list individual ingredient amounts
- More expensive per serving
- May cause cramping in some users
Bottom Line: Ideal if you want a complete gallbladder support formula rather than ox bile alone.
7. Therexa Gallbladder Formula — Best Complete Digestive Blend
- Ox Bile Supplements Power: Our targeted gallbladder formula pairs ox bile + conjugated bile acids with betaine HCl, pancreatin, and pepsin; smart gallbladder supplements support, including for those with no gallbladder, or gallbladder cleanse.
- Bile Salts Defined: Bile-acid compounds that emulsify fats. This bile salts supplement uses purified bile salts (conjugated bile acids) for efficient fat breakdown - an optimal option among bile acid supplements.
- Ox Bile (aka oxbile) Explained: Exogenous bile acids for fatty meals; practical gallbladder support if you’ve got no gallbladder.
- Liver Gallbladder Complex: Choline, stoneroot, slippery elm, and enzymes form a balanced matrix; our liver gallbladder complex ox bile approach complements gentle gallbladder cleanse aims within premium bile supplements.
- Digestive Enzymes with Ox Bile: Pancreatin + pepsin + ox bile + betaine HCl = a complete “digestive enzymes ox bile” combo to handle diverse meals.
Therexa delivers a balanced digestive enzyme complex centered around ox bile and purified bile salts.
This formula combines ox bile with conjugated bile acids, betaine HCl, pancreatin, and pepsin to support comprehensive digestion of all macronutrients. The addition of choline, stoneroot, and slippery elm provides botanical support for liver and gallbladder health. With 90 vegetable capsules, you get a targeted approach to digestive wellness.
What We Like
- Includes both ox bile and conjugated bile acids
- Full spectrum of digestive enzymes
- Botanical liver support ingredients
- 90-day money-back guarantee
- cGMP manufacturing standards
What Could Be Better
- Complex formula may not be needed for everyone
- Multiple active ingredients could cause sensitivity
Bottom Line: A well-rounded option for those who want comprehensive digestive support beyond ox bile alone.
How to Choose the Best Ox Bile Supplement
Selecting the right ox bile supplement requires understanding your specific digestive needs and what to look for in a quality product.
First, consider the bile salt standardization. The most important factor is whether the supplement is standardized to contain specific percentages of cholic acid or other bile salts. Products standardized to 40-45% bile salts ensure you’re getting therapeutic amounts of the active compounds. Generic ox bile without standardization may contain minimal bile salts, making it less effective.
Dosage matters significantly. If you’ve had your gallbladder removed, you’ll typically need 500-1000mg of ox bile with fatty meals. Those with intact gallbladders who just need digestive support may do well with 125-500mg. Look for products that allow flexible dosing — either lower-dose capsules you can stack or scored tablets you can split.
Quality sourcing is essential. Choose supplements from grass-fed, pasture-raised cattle when possible. The manufacturing facility should follow GMP (Good Manufacturing Practices) standards, and third-party testing adds an extra layer of quality assurance. Check for certifications from independent labs that verify purity and potency.
Consider whether you need a standalone ox bile supplement or a comprehensive formula. If you primarily struggle with fat digestion, pure ox bile may be sufficient. However, if you have broader digestive issues, formulas combining ox bile with pancreatic enzymes, betaine HCl, or other digestive aids might be more beneficial.
Watch for allergens and additives. Quality ox bile supplements should be free from common allergens like gluten, dairy, and soy. Avoid products with unnecessary fillers, artificial colors, or preservatives. The simpler the ingredient list beyond the active ox bile, the better.
Benefits of Ox Bile Supplements
Ox bile supplements provide targeted support for fat digestion, particularly important for people who’ve had their gallbladder removed or those with compromised bile production.
The primary benefit is improved fat digestion. Bile salts act as emulsifiers, breaking down large fat globules into smaller droplets that digestive enzymes can more easily process. This is crucial because without adequate bile, dietary fats can pass through your digestive system unabsorbed, leading to fatty stools, bloating, and nutrient deficiencies. Ox bile supplements provide the concentrated bile salts your body needs to properly digest fats from meals.
Better absorption of fat-soluble vitamins is another key advantage. Vitamins A, D, E, and K require fat for absorption. When bile production is insufficient, you can develop deficiencies in these critical nutrients even if you’re consuming them in adequate amounts. By supporting fat digestion, ox bile helps ensure these essential vitamins make it into your bloodstream where they can support immune function, bone health, and numerous other physiological processes.
Many people experience relief from digestive discomfort when taking ox bile. Symptoms like bloating, gas, and abdominal cramping after fatty meals often indicate inadequate bile flow. By supplementing with ox bile, you provide your digestive system with the tools it needs to break down fats efficiently, reducing the fermentation and bacterial overgrowth that contribute to uncomfortable symptoms.
For those without a gallbladder, ox bile can be life-changing. The gallbladder stores and concentrates bile between meals, releasing it when you eat fatty foods. Without this reservoir, bile drips continuously but in insufficient amounts for proper fat digestion. Ox bile supplements essentially replace this storage function, providing concentrated bile salts when you need them most — during and after meals.
Frequently Asked Questions
When should I take ox bile supplements?
Take ox bile supplements with meals that contain fat, typically at the beginning or middle of your meal. This timing allows the bile salts to be present when your body is actively digesting dietary fats. For best results, take ox bile with your fattiest meal of the day. If you’ve had your gallbladder removed, you may need to take it with every meal containing more than a small amount of fat.
How much ox bile should I take?
Dosing depends on your individual needs and whether you have your gallbladder. Those without a gallbladder typically need 500-1000mg with each fatty meal. People with intact gallbladders who need digestive support often do well with 125-500mg per meal. Start with a lower dose and increase gradually based on your digestive response. Some people find they need more ox bile with very fatty meals and less with lighter meals.
Can I take ox bile if I still have my gallbladder?
Yes, you can take ox bile even with an intact gallbladder. Many people benefit from supplemental bile salts even when their gallbladder is functioning. Conditions like sluggish bile flow, liver dysfunction, or simply aging can reduce bile production. The supplement works by providing additional bile salts to support fat digestion. However, start with lower doses (125-250mg) to assess tolerance.
Are there any side effects of ox bile supplements?
Most people tolerate ox bile well, but some may experience loose stools or diarrhea, especially when first starting or if taking too much. This occurs because excess bile salts in the colon draw water into the intestines. If this happens, reduce your dose. Some people report mild cramping, which usually resolves with continued use. Rarely, people may experience headaches or nausea. If you experience persistent side effects, consult your healthcare provider.
What’s the difference between ox bile and bile salts?
Ox bile is the complete bile extract from bovine sources, containing bile salts along with other bile components like cholesterol and bilirubin. Bile salts (also called bile acids) are the active compounds within bile that actually emulsify fats. Standardized ox bile supplements specify the percentage of bile salts, typically 40-45% cholic acid. Pure bile salt supplements contain only the active compounds without the other bile components.
Do I need a prescription for ox bile supplements?
No, ox bile is available as an over-the-counter dietary supplement and doesn’t require a prescription. However, if you’re considering ox bile supplementation, especially after gallbladder removal or for a specific digestive condition, it’s wise to discuss it with your healthcare provider. They can help determine if it’s appropriate for your situation and guide you on proper dosing.
Can ox bile help with SIBO or IBS?
Ox bile may help some people with SIBO (Small Intestinal Bacterial Overgrowth) or IBS (Irritable Bowel Syndrome), particularly when fat malabsorption is involved. Bile salts have mild antimicrobial properties and can help maintain a healthy balance of gut bacteria. For IBS-D (diarrhea predominant), ox bile should be used cautiously as it can worsen symptoms in some people. For IBS-C (constipation predominant), it may be more beneficial. Working with a knowledgeable practitioner is recommended.
Is ox bile the same as TUDCA?
No, ox bile and TUDCA (tauroursodeoxycholic acid) are different compounds, though both relate to bile. TUDCA is a specific bile acid that has unique cellular protective properties and is often used for liver support. Ox bile contains various bile acids including cholic acid, primarily used for fat digestion support. While both support digestive and liver health, they work through different mechanisms and are used for different primary purposes.
