Best Phosphatidylserine Supplements for Brain Health (2026) – Top 10 Reviewed
Phosphatidylserine (PS) is a phospholipid that’s essential for maintaining healthy brain cell membranes and supporting cognitive function. As your body’s natural production declines with age, supplementation has become increasingly popular for memory support, mental clarity, and stress management.
The best phosphatidylserine supplements use high-quality sources like sunflower or soy lecithin, deliver clinically studied dosages, and come from reputable manufacturers. Here are our top 10 picks for 2026.
| Product | Key Ingredients | Servings | Form | Best For |
|---|---|---|---|---|
| Double Wood Phosphatidylserine 300mg | PS from Soy Lecithin | 120 | Capsules | Best Overall |
| MemoryXL Magnesium L-Threonate + PS | Magtein, PS, B Vitamins | 30 | Powder Sticks | Best Nootropic Stack |
| Nutricost Phosphatidylserine 400mg | PS from Sunflower | 30 | Capsules | Best Soy-Free |
| Life Extension PS Caps 100mg | PS from Sunflower | 100 | Capsules | Best for Daily Use |
| Jarrow Formulas PS100 | Sharp-PS from Sunflower | 120 | Softgels | Best Trusted Brand |
| Neviss Kids 10+ Focus Brain Gummies | PS, Lion’s Mane, B12 | 60 | Gummies | Best for Teens/Adults |
| Doctor’s Best Phosphatidyl Serine 100mg | SerinAid PS | 120 | Capsules | Best Value |
| Alpha GPC Choline + PS Gummies | Alpha GPC, PS, Bacopa | 60 | Gummies | Best 3-in-1 Formula |
| Ginkgo Biloba 120mg with PS | Ginkgo, PS | 60 | Capsules | Best for Circulation |
| Cognagen Memory Supplement | Ultra High Potency PS | 60 | Capsules | Best High-Potency |
1. Double Wood Phosphatidylserine 300mg – Best Overall
Why it stands out: Double Wood delivers a clinically relevant 300mg dose per serving in a straightforward, no-frills formula that’s been a top seller for years. Third-party tested for purity and manufactured in the USA.
Double Wood’s phosphatidylserine provides the exact dosage used in clinical studies showing benefits for memory, attention, and processing speed. The 120-capsule bottle delivers a 40-day supply at the full 300mg daily dose, making it excellent value for serious cognitive support. Studies have shown that 300-400mg of PS daily can support memory and processing speed, particularly in adults experiencing mental fatigue. The formula uses PS derived from soy lecithin, which has been the most extensively studied source in clinical research. Double Wood’s reputation for transparency—including publishing third-party test results—adds confidence that you’re getting exactly what’s on the label.
Pros:
- Clinically studied 300mg dosage
- Third-party tested for purity
- USA manufactured in New York
- Non-GMO and gluten-free
Cons:
- Contains soy (not suitable for those with soy allergies)
Best for: Anyone looking for a straightforward, effective phosphatidylserine supplement at a proven dosage.
2. MemoryXL Magnesium L-Threonate + PS – Best Nootropic Stack
Why it stands out: This innovative formula combines phosphatidylserine with Magtein (magnesium L-threonate), the only form of magnesium clinically shown to cross the blood-brain barrier, plus a comprehensive B vitamin complex.
MemoryXL takes a synergistic approach to brain health by combining multiple evidence-based ingredients. The Magtein magnesium L-threonate supports synaptic density and plasticity—research from MIT showed this specific form of magnesium is uniquely able to elevate brain magnesium levels. Meanwhile, phosphatidylserine maintains cell membrane health, and the B vitamin complex supports neurotransmitter synthesis. The convenient powder stick format with cranberry lemon flavor makes it easy to take daily—just mix with water or add to your morning routine. Each serving is sugar-free and zero-calorie, making it suitable for ketogenic, low-carb, or calorie-conscious diets.
Pros:
- Patented Magtein magnesium L-threonate
- Multi-ingredient cognitive support
- Convenient powder stick format
- Zero sugar, zero calories
- Pleasant cranberry lemon flavor
Cons:
- More expensive than standalone PS supplements
- Lower PS dose than single-ingredient options
Best for: Those wanting comprehensive nootropic support beyond just phosphatidylserine.
3. Nutricost Phosphatidylserine 400mg – Best Soy-Free
Why it stands out: Derived from sunflower lecithin instead of soy, Nutricost delivers 400mg per serving—one of the highest doses available—while remaining allergen-friendly and budget-conscious.
Nutricost’s soy-free formula is perfect for those with soy sensitivities or anyone preferring sunflower-derived supplements. The 400mg dose per serving (4 capsules) provides flexibility to adjust your intake based on needs—you can take the full dose for maximum support or split it into smaller amounts throughout the day. The vegetarian-friendly capsules are manufactured in a GMP-compliant facility and undergo rigorous third-party testing for purity and potency. Nutricost has built a strong reputation for delivering high-quality supplements at competitive prices, and their phosphatidylserine is no exception. At 30 servings per bottle, it offers solid value for a high-potency option, though frequent users may want to consider their bulk purchasing options.
Pros:
- Soy-free, derived from sunflower lecithin
- High 400mg dose per serving
- Vegetarian-friendly capsules
- GMP-compliant manufacturing
- Non-GMO and gluten-free
Cons:
- Requires taking 4 capsules per serving
- 30 servings per bottle (not as economical long-term)
Best for: Those with soy allergies or sensitivities who want a high-potency PS supplement.
4. Life Extension PS Caps 100mg – Best for Daily Use
Why it stands out: Life Extension is known for rigorous quality standards and science-backed formulations. Their PS Caps deliver a moderate 100mg dose derived from sunflower lecithin, ideal for consistent daily maintenance.
Life Extension’s approach focuses on quality ingredients and scientific backing over high doses. The 100mg per capsule allows you to easily customize your dose—take one capsule for maintenance support or up to three for a full 300mg clinical dose. The vegetarian capsules use sunflower lecithin as the source, avoiding soy entirely while still delivering bioavailable PS. With 100 capsules per bottle, you get excellent flexibility and value—at maintenance dosing, a single bottle lasts over three months. Life Extension’s 35+ year reputation for quality, their commitment to funding independent research, and their rigorous testing protocols add substantial confidence to your purchase.
Pros:
- Flexible dosing (1-3 capsules daily)
- Sunflower-derived, soy-free
- Vegetarian capsules
- 100-day supply at maintenance dose
- Trusted brand with decades of reputation
Cons:
- Lower per-capsule dose requires multiple capsules for clinical dosing
- Premium pricing
Best for: Those who prefer flexible dosing options from a trusted, science-focused brand.
5. Jarrow Formulas PS100 – Best Trusted Brand
Why it stands out: Jarrow Formulas uses Sharp-PS, a patented form of phosphatidylserine from sunflower lecithin known for stability and purity. Their PS100 has been a category leader for years.
Jarrow’s PS100 softgels deliver 100mg of concentrated phosphatidylserine using the Sharp-PS brand ingredient, which has been used in clinical research. The softgel format enhances absorption compared to standard capsules. The formula is free from wheat, soybeans, dairy, egg, fish, shellfish, peanuts, tree nuts, and sesame—making it one of the most allergen-friendly options available. Each bottle provides 40-120 days of supplementation depending on your dose.
Pros:
- Patented Sharp-PS ingredient
- Sunflower-derived, soy-free
- Softgel for enhanced absorption
- Free from 9 major allergens
- Non-GMO and gluten-free
Cons:
- Contains bovine gelatin (not vegetarian)
- Must take multiple softgels for higher doses
Best for: Those who want a premium, research-backed PS supplement with excellent allergen considerations.
6. Neviss Kids 10+ Focus Brain Gummies – Best for Teens/Adults
Why it stands out: This sugar-free gummy formula combines phosphatidylserine with lion’s mane mushroom, B vitamins, choline, and ginkgo biloba—all in a tasty, easy-to-take format that appeals to younger users and adults who dislike pills.
Neviss takes a comprehensive approach to cognitive support with their multi-ingredient gummy. Lion’s mane mushroom provides nerve growth factor support, while B6, B12, and choline complement the phosphatidylserine for neurotransmitter production. The sugar-free formula includes beetroot and L-tyrosine for additional brain-supporting benefits. Perfect for teens struggling with focus or adults who want cognitive support without swallowing capsules.
Pros:
- Comprehensive brain support formula
- Sugar-free gummy format
- Contains lion’s mane and B vitamins
- Includes choline for neurotransmitter support
- Suitable for ages 10+
Cons:
- Lower PS dose than standalone supplements
- Contains multiple active ingredients (may not suit those wanting pure PS)
Best for: Teens, young adults, or anyone who prefers a gummy format with comprehensive cognitive support.
7. Doctor’s Best Phosphatidyl Serine 100mg – Best Value
Why it stands out: Doctor’s Best uses SerinAid, a branded phosphatidylserine ingredient, at an affordable price point. Their 120-capsule bottle provides excellent long-term value.
Doctor’s Best has been providing science-based supplements for over 35 years, and their phosphatidylserine is no exception. The SerinAid PS is a well-researched form that supports healthy nerve cell communication and cognitive function. The vegetarian-friendly capsules make this suitable for most dietary preferences. At 120 capsules per bottle, taking the recommended 1-3 capsules daily with food provides 40-120 days of supplementation at an attractive price.
Pros:
- SerinAid branded ingredient
- Vegetarian/vegan friendly
- 120 capsules per bottle
- Budget-friendly pricing
- Gluten-free
Cons:
- Contains soy (derived from soy lecithin)
- Basic formula without additional brain-supporting ingredients
Best for: Budget-conscious buyers who want a reliable, straightforward PS supplement.
8. Alpha GPC Choline + Phosphatidylserine Gummies – Best 3-in-1 Formula
Why it stands out: This innovative formula combines three proven cognitive supporters—Alpha GPC, phosphatidylserine, and Bacopa monnieri—in a convenient sugar-free gummy format.
Alpha GPC is considered one of the most bioavailable forms of choline for brain health, supporting acetylcholine production for memory and learning. Combined with phosphatidylserine for cell membrane support and Bacopa monnieri for long-term cognitive health, this formula addresses multiple pathways of brain function. The 60-count bottle provides a month’s supply with the sugar-free gummy format making daily compliance easy.
Pros:
- Triple-action cognitive support
- Highly bioavailable Alpha GPC choline
- Includes Bacopa for long-term benefits
- Sugar-free gummies
- Natural formula
Cons:
- Lower individual ingredient doses than standalone products
- Not ideal for those wanting pure PS supplementation
Best for: Those wanting synergistic brain support from multiple nootropic ingredients in one convenient product.
9. Ginkgo Biloba 120mg with Phosphatidylserine – Best for Circulation
Why it stands out: This combination formula pairs phosphatidylserine with ginkgo biloba, an herb traditionally used to support cerebral blood flow and mental alertness.
The synergy between ginkgo biloba and phosphatidylserine makes this formula particularly appealing for those concerned about brain circulation and oxygenation. Ginkgo supports blood flow to the brain, while PS maintains healthy cell membranes—together addressing both the delivery system and the cellular infrastructure of cognitive function. The 60-capsule bottle provides a 2-month supply at the standard one-capsule daily dose.
Pros:
- Combines circulation and membrane support
- 2-month supply per bottle
- Non-GMO capsules
- Supports mental clarity and alertness
- Budget-friendly combination formula
Cons:
- Lower PS dose than standalone supplements
- Ginkgo may interact with blood thinners
Best for: Those wanting combined circulatory and cellular brain support, particularly older adults.
10. Cognagen Memory Supplement – Best High-Potency
Why it stands out: Cognagen uses an ultra high potency phosphatidylserine formula specifically designed for maximum memory and focus support, with a soy-free formulation.
Cognagen focuses exclusively on delivering therapeutic-level phosphatidylserine for those who want serious cognitive support. The clinically formulated supplement is designed specifically for memory and focus enhancement. The soy-free, non-GMO formula addresses common allergen concerns while the 60-capsule bottle provides a full month of supplementation. Made in the USA with quality manufacturing standards.
Pros:
- Ultra high potency formula
- Soy-free formulation
- Specifically designed for memory support
- Non-GMO ingredients
- USA manufactured
Cons:
- Smaller bottle size (60 capsules)
- Premium pricing for specialty formula
Best for: Those experiencing noticeable cognitive decline who want maximum-strength phosphatidylserine support.
What is Phosphatidylserine and Who Should Take It?
Phosphatidylserine is a phospholipid—a type of fat containing phosphorus—that’s a critical component of cell membranes throughout your body, with particularly high concentrations in the brain. It plays essential roles in cell signaling, neurotransmitter release, and maintaining the fluidity and structure of brain cell membranes. PS facilitates the release of neurotransmitters like dopamine and acetylcholine, which are crucial for memory formation, learning, and mood regulation.
Your body produces phosphatidylserine naturally, but production declines significantly with age—some research suggests brain PS levels can drop by as much as 15-20% between ages 20 and 80. This decline has been associated with age-related cognitive changes, making supplementation particularly relevant for several groups.
Adults over 50 experiencing mild memory concerns often benefit most from PS supplementation, as clinical studies have shown improvements in memory recall, word recognition, and processing speed. High-stress individuals may find PS helpful for cortisol regulation—research indicates that 400-800mg daily can help blunt the cortisol response to physical and mental stress. Students and professionals seeking mental performance support during demanding periods, as well as athletes looking for exercise recovery benefits and reduced muscle soreness, round out the primary candidates for PS supplementation.
How to Choose the Right Phosphatidylserine Supplement
Key Ingredients to Look For
The standard clinical dose for phosphatidylserine is 300mg daily, typically divided into three 100mg doses taken with meals. Some studies have used doses up to 400-800mg daily for stress reduction and athletic performance benefits. Look for supplements using branded ingredients like Sharp-PS (from Enzymotec/IFF) or SerinAid, which have been used in clinical research and offer quality assurance through standardized manufacturing processes.
When evaluating ingredient quality, check whether the phosphatidylserine is derived from sunflower lecithin (soy-free) or soy lecithin. Both sources are effective, but sunflower-derived PS has become increasingly popular due to allergen concerns. The phosphatidylserine content should be clearly stated on the label—some products list “phospholipid complex” without specifying the actual PS content, which makes dosing difficult.
Forms Compared
Capsules are the most common delivery method, offering precise dosing and easy storage. Standard vegetarian capsules work well for most people. Softgels use a lipid-based delivery that may enhance absorption since phosphatidylserine is fat-soluble—this format is particularly beneficial for those who don’t typically take their supplements with fatty foods.
Gummies have gained popularity for their convenience and palatability, making daily compliance easier for those who dislike swallowing pills. However, gummy formulations typically contain lower PS doses per serving and may include added sugars or sweeteners. Powder formats offer maximum dosing flexibility and can be easily mixed into smoothies, coffee, or other beverages, though they may have stability concerns and often require refrigeration.
What to Avoid
Historically, phosphatidylserine was derived from bovine (cow) brain tissue, but this source was phased out in the late 1990s due to concerns about transmitting diseases like BSE (mad cow disease). Modern supplements use soy or sunflower lecithin—both are considered safe and have similar efficacy in clinical studies.
Red flags when shopping include products that don’t clearly disclose their PS source, supplements with excessive fillers or artificial additives, formulas that hide ingredient amounts behind “proprietary blends,” and products from manufacturers without third-party testing or quality certifications. Also be cautious of extremely low-priced options, as quality PS ingredients have a baseline cost that reputable manufacturers can’t undercut without compromising quality.
Side Effects and Precautions
Phosphatidylserine is generally well-tolerated at doses up to 300mg daily, with clinical studies showing excellent safety profiles over periods of 6 months or longer. The most commonly reported side effects are mild digestive issues, including stomach upset, nausea, or gas, particularly when starting supplementation or taking higher doses. These effects typically diminish after the first week as your body adjusts.
Insomnia has been reported in some users, possibly due to PS’s effects on neurotransmitter activity. If sleep disturbances occur, try taking your dose earlier in the day—morning or early afternoon—rather than in the evening. Some individuals also report increased mental energy, which while generally positive, can interfere with sleep if dosing timing isn’t optimized.
Those taking blood-thinning medications like warfarin or aspirin should consult their healthcare provider before supplementing with phosphatidylserine, as PS may have mild blood-thinning effects. Similarly, people taking anticholinergic medications or drugs that affect acetylcholine levels should seek medical guidance, as PS influences cholinergic neurotransmission. Pregnant or breastfeeding women should avoid PS supplementation due to insufficient safety data in these populations.
Individuals with bleeding disorders, those scheduled for surgery (discontinue at least 2 weeks prior), and anyone taking medications for Alzheimer’s disease or other neurological conditions should discuss PS supplementation with their healthcare provider before starting.
FAQs
How much phosphatidylserine should I take daily?
The standard recommended dose is 100-300mg daily, typically divided into doses taken with meals for optimal absorption. Most clinical studies demonstrating cognitive benefits used 300mg daily, divided into three 100mg doses with breakfast, lunch, and dinner. Some research on stress reduction and athletic performance used higher doses of 400-800mg daily. Start with a lower dose (100mg) and increase gradually over 2-3 weeks to assess tolerance before reaching your target dose.
When is the best time to take phosphatidylserine?
Take phosphatidylserine with meals to enhance absorption, as it’s a fat-soluble nutrient that benefits from dietary fats present during digestion. Dividing your dose across meals (such as 100mg three times daily) distributes the benefits throughout the day and may be more effective than taking a single large dose. Morning or afternoon dosing is generally preferred—if you experience any sleep disturbances, avoid evening doses. For cortisol management, some practitioners recommend taking PS before anticipated stressful events.
How long does it take for phosphatidylserine to work?
Initial subtle effects on mood and stress response may be noticed within 2-4 weeks of consistent daily use. However, significant cognitive benefits—improvements in memory, processing speed, and mental clarity—typically appear after 6-12 weeks of daily supplementation. Some clinical studies showed continued improvement over 3-6 months of use, suggesting that PS benefits may accumulate over time. Patience and consistency are key; phosphatidylserine works by gradually supporting cell membrane health rather than providing immediate stimulant-like effects.
Can I take phosphatidylserine with other nootropics?
Yes, phosphatidylserine stacks synergistically with many cognitive supplements. Omega-3 fatty acids (particularly DHA) work alongside PS to maintain brain cell membrane integrity. Ginkgo biloba complements PS by supporting cerebral blood flow. Bacopa monnieri provides additional memory support through different mechanisms. Choline sources like Alpha GPC or citicoline support acetylcholine production that PS helps facilitate. Many commercial “brain health” stacks include PS as a core ingredient alongside these complementary compounds.
Is soy-based or sunflower-based phosphatidylserine better?
Both sources are clinically effective and considered safe by regulatory agencies. Sunflower-derived PS has become increasingly popular because it’s allergen-free, making it suitable for those with soy sensitivities or those following elimination diets. Some research suggests sunflower-derived PS may have slightly different phospholipid profiles, potentially with higher phosphatidylcholine content, but clinical outcomes appear similar between sources. The choice typically comes down to allergen considerations and personal preference rather than significant efficacy differences.
Are there any drug interactions with phosphatidylserine?
PS may interact with several medication categories. Blood thinners (anticoagulants like warfarin, antiplatelet drugs like aspirin) may have enhanced effects when combined with PS, potentially increasing bleeding risk. Anticholinergic medications may have reduced effectiveness. Cholinergic drugs used for Alzheimer’s disease (like donepezil) may have enhanced effects. Medications affecting sleep or mood could have altered effects due to PS’s influence on neurotransmitters. Always consult your healthcare provider before starting PS if you take prescription medications, especially for neurological conditions, blood disorders, or mood-related issues.
Final Verdict
For most people seeking straightforward phosphatidylserine supplementation, Double Wood Phosphatidylserine 300mg offers the best combination of clinical dosing, quality manufacturing, third-party testing, and value. It delivers exactly what the research supports—a full 300mg daily dose—at a fair price with transparent sourcing.
If you need a soy-free option, Nutricost Phosphatidylserine 400mg provides the highest dose from sunflower lecithin, making it ideal for those with soy allergies or anyone wanting maximum-strength supplementation. The 400mg dose also aligns with studies showing benefits for stress reduction.
For those wanting comprehensive brain support beyond just phosphatidylserine, MemoryXL Magnesium L-Threonate + PS combines multiple research-backed ingredients—including the patented Magtein form of magnesium—in one convenient daily formula. This is particularly appealing for those who don’t want to manage multiple supplements.
Budget-conscious buyers will find excellent value in Doctor’s Best Phosphatidyl Serine, which uses the branded SerinAid ingredient at an accessible price point. Meanwhile, those who prefer established brands with decades of reputation and rigorous quality standards should consider Life Extension PS Caps or Jarrow Formulas PS100—both companies have long track records in the supplement industry and use premium ingredients.
For younger users, students, or anyone who struggles with pills, Neviss Kids 10+ Focus Brain Gummies provides a comprehensive cognitive support formula in an easy-to-take format. The combination of PS with lion’s mane and B vitamins makes it a solid choice for focus and concentration support.
Whichever option you choose, remember that consistency is key with phosphatidylserine. Plan to supplement daily for at least 2-3 months to fully evaluate the benefits for your cognitive health.
