Best Phosphatidylserine Supplements for Sleep (2026) – Top 10 Reviewed
If racing thoughts and elevated stress hormones keep you awake at night, phosphatidylserine might be the missing piece in your sleep routine. This powerful phospholipid works by lowering cortisol levels—the stress hormone that can interfere with falling asleep and staying asleep. In this comprehensive guide, we’ll explore the best phosphatidylserine supplements that support better sleep by managing stress and promoting a calm, relaxed state conducive to rest.
Our Top Picks at a Glance
- Best Overall: Double Wood Phosphatidylserine – clinically proven dose with excellent purity
- Best Value: Doctor’s Best Phosphatidylserine – affordable quality from trusted brand
- Best Premium: Thorne Phosphatidylserine – pharmaceutical-grade purity and testing
Quick Comparison
| Product | Dosage Per Serving | Form | Servings | Best For |
|---|---|---|---|---|
| Double Wood PS | 300mg | Capsules | 120 | Clinical strength |
| Doctor’s Best PS 100 | 100mg | Capsules | 120 | Budget-friendly |
| Thorne PS | 100mg | Capsules | 60 | Premium quality |
| Nutricost PS 400mg | 400mg | Capsules | 120 | High potency |
| NatureBell PS 500mg | 500mg | Capsules | 240 | Maximum strength |
| Integrative Therapeutics | 100mg | Softgels | 60 | Healthcare professional grade |
| Allbe SleepCan | PS + Melatonin + L-Theanine | Capsules | 90 | Complete sleep formula |
| NOW PS 300mg | 300mg | Softgels | 50 | Extra strength |
1. Double Wood Phosphatidylserine 300mg – Best Overall
- SUPPORTS MEMORY AND ATTENTION: Clinically shown to assist with memory recall and sharpen focus in healthy adults. A 300mg daily dose is optimized for peak results
- SUPPORTS OVERALL COGNITIVE HEALTH: Multiple studies have shown that Phosphatidylserine may help support attention and cognitive function in healthy adults
- MAY BOOST COGNITIVE PERFORMANCE: Studies have shown that Phosphatidylserine supports brain health, including memory, processing speed, and focus
- ROOTED IN QUALITY: Double Wood's Phosphatidylserine is manufactured right here in the USA from globally sourced ingredients, Non-GMO, and gluten-free
- WE BOTTLE WELLNESS: At Double Wood, we provide pure, potent supplements that deliver exceptional value, all backed by careful sourcing and rigorous third-party testing
For clinically proven cortisol reduction and sleep support, Double Wood delivers pharmaceutical-grade phosphatidylserine at the optimal research-backed dosage.
This formula provides 300mg of phosphatidylserine per serving (two capsules), matching the dosage shown in multiple clinical studies to reduce elevated cortisol levels and support healthy stress responses. The phosphatidylserine is sourced from non-GMO sunflower lecithin, making it soy-free and suitable for those with soy sensitivities. Manufactured in the USA with rigorous third-party testing for purity and potency, Double Wood’s commitment to quality ensures you’re getting exactly what the label promises. The 120-capsule bottle provides a two-month supply at the optimal dosage.
What We Like
- Clinical 300mg dose proven to reduce cortisol
- Soy-free from sunflower lecithin
- Manufactured in USA with third-party testing
- Non-GMO and gluten-free
- Excellent value for research-backed dosage
What Could Be Better
- Requires two capsules per serving
- Not standardized to specific phospholipid percentage
Bottom Line: The gold standard for phosphatidylserine sleep support, offering clinical-strength cortisol management at an exceptional value.
2. Doctor’s Best Phosphatidylserine 100mg – Best Value
- Best Phosphatidylserine provides the essential brain nutrient phosphatidylserine in a matrix of other phospholipids and cofactors
- Product Note: Exposure to heat or sunlight may lead to melting/damage of product. Hence customers are expected to be available during the product delivery
- Phosphatidylserine and other phospholipids are structural components of brain neurons that can enhance cell-to-cell communication
- Studies have shown the ability of supplemental phosphatidylserine to support healthy cognitive function
- It may enhance healthy memory and thinking ability by facilitating communication between neurons
Get trusted quality at an affordable price with Doctor’s Best, a brand backed by over 35 years of science-based supplement manufacturing.
Each veggie capsule delivers 100mg of phosphatidylserine in a matrix of other phospholipids and cofactors that support healthy nerve cell communication. The lower per-capsule dose allows flexible dosing – take one capsule for mild support or three for the full clinical dose. Doctor’s Best emphasizes quality with gluten-free, vegan formulation suitable for various dietary needs. The phosphatidylserine supports memory, learning, and cognitive functions while helping your body manage stress hormones that interfere with sleep.
What We Like
- Excellent price-to-quality ratio
- Flexible dosing with 100mg capsules
- Vegan and gluten-free
- Trusted brand with 35+ years experience
- Contains supportive phospholipids
What Could Be Better
- Requires three capsules for clinical dose
- Basic formula without sleep-specific ingredients
Bottom Line: A budget-friendly option from a reputable brand that delivers quality phosphatidylserine with dosing flexibility.
3. Thorne Phosphatidylserine (Iso-Phos) – Best Premium
- Phosphatidylserine: Supports healthy brain function*
- Stress/Sleep: Helps modulate cortisol levels during stress*
- Memory: Supports memory and focus*
- Third-Party Certified: This product has been third-party tested and certified to verify what's in the package matches what's on the label and to confirm it contains no unsafe levels of contaminants
- Trusted: Thorne is chosen by champions and trusted by 100+ professional sports teams, a proud partner of U.S. National Teams, and the #1 recommended clinical brand by health-care practitioners (2023 Health-Care Practitioner Seller Survey)
When only pharmaceutical-grade quality will do, Thorne delivers the highest purity phosphatidylserine for cortisol management and sleep support.
Thorne’s phosphatidylserine isolate provides 100mg per capsule of ultra-pure PS free from common allergens. As a brand trusted by healthcare practitioners worldwide, Thorne applies pharmaceutical-grade manufacturing standards including rigorous third-party testing. While derived from soy, the isolation process ensures the highest purity. The formula specifically supports cortisol management, making it ideal for stress-related sleep issues. Each batch undergoes extensive testing for potency, purity, and contamination.
What We Like
- Pharmaceutical-grade quality and testing
- Trusted by healthcare professionals
- Highly purified isolate form
- Specifically supports cortisol and sleep
- NSF Certified for Sport
What Could Be Better
- Premium pricing
- Derived from soy (though highly purified)
Bottom Line: The premium choice for those who want the absolute highest quality phosphatidylserine for stress and sleep support.
4. Nutricost Phosphatidylserine 400mg – Best High Potency
- 120 Phosphatidyl Serine Capsules Per Bottles
- 400mg of Soy-Free Phosphatidyl Serine Per Serving
- 4 Plant-Based Capsules Per Serving
- Vegetarian Friendly, Non-GMO, Gluten Free, Soy Free
- Manufactured in an NSF Certified, GMP Compliant, FDA Registered Facility
For those who need maximum phosphatidylserine support, Nutricost delivers 400mg per serving from soy-free sunflower lecithin.
This high-potency formula provides 400mg of phosphatidylserine per two-capsule serving, exceeding the typical clinical dose for enhanced cortisol management. The plant-based formula is sourced from sunflower lecithin, making it soy-free and suitable for those with soy sensitivities. Manufactured in a GMP-compliant facility, Nutricost ensures quality without the premium price tag. The vegetarian capsules are non-GMO and gluten-free, and the 120-capsule bottle provides a full month supply at the high dosage.
What We Like
- High 400mg dose per serving
- Soy-free from sunflower lecithin
- GMP-certified manufacturing
- Vegetarian, non-GMO, gluten-free
- Good value for high-potency option
What Could Be Better
- Very high dose may be unnecessary for some
- Two capsules required per serving
Bottom Line: An excellent high-potency choice for individuals with significant stress-related sleep issues needing maximum support.
5. NatureBell Phosphatidylserine 500mg – Best Maximum Strength
- Brain Health & Function: NatureBell Phosphatidylserine delivers 500mg per serving to help support overall brain health and function for both men and women*
- Sunflower Lecithin Source: Derived from high-purity sunflower lecithin, this phosphatidylserine formula provides a clean, soy-free source of an essential healthy brain fat*
- Bioavailable & Standardized Formula: Standardized to 20% active ingredients, this phosphatidylserine supplement offers a bioavailable form designed for consistent daily brain health support*
- Third-Party Tested: These vegetarian capsules are third-party tested for potency and safety; they are also free of wheat, dairy, gluten, preservatives, eggs, and fish
- Pure, High-Quality Ingredients: At NatureBell, we use only the finest ingredients to help support you on your health and wellness journey
Get the highest phosphatidylserine dose available with NatureBell’s 500mg formula for serious cortisol management needs.
This maximum-strength formula delivers 500mg of phosphatidylserine per two-capsule serving, standardized to 20% active ingredients for consistent potency. Derived from high-purity sunflower lecithin, it’s completely soy-free and suitable for various dietary needs. The bioavailable, standardized formula is designed for optimal absorption and effectiveness. Third-party tested and manufactured in the USA, NatureBell provides 240 capsules per bottle – a four-month supply at the maximum dose. The vegetarian capsules are free from wheat, dairy, and other common allergens.
What We Like
- Highest dose available (500mg)
- Standardized to 20% active ingredients
- Soy-free from sunflower lecithin
- Excellent four-month supply
- Third-party tested for safety and potency
What Could Be Better
- Very high dose may cause side effects in sensitive users
- Larger capsules due to high concentration
Bottom Line: The ultimate maximum-strength option for individuals with severe stress-related sleep disturbances requiring intensive support.
6. Integrative Therapeutics Phosphatidylserine – Best Professional Grade
- Brain Health Support Supplement*: Phosphatidylserine is a naturally occurring phospholipid and a critical component of cell membranes, especially in brain and nervous tissues*
- Stress Support Supplement*: Research shows that phosphatidylserine supplementation may support brain function and a healthy response to stress*
- Brain Function Support Supplement*: This concentration support supplement uses ingredients derived from sunflower oil and is 100% soy-free*
- Gluten-Free & Dairy-Free: Phosphatidylserine contains no salt, wheat, gluten, soy, dairy, or artificial colors
- About Integrative Therapeutics: For over 25 years, patients and clinicians have trusted us for our dedication to quality, potency, and accuracy; transparency around our sourcing and manufacturing processes is part of our quality promise to you
Trusted by healthcare professionals for over 25 years, Integrative Therapeutics delivers clinical-grade phosphatidylserine in easy-to-absorb softgels.
This professional-grade formula uses Sharp-PS, a patented form of phosphatidylserine derived from sunflower lecithin. Each softgel provides 100mg of PS in a highly bioavailable medium-chain triglyceride base for enhanced absorption. The soy-free, dairy-free, and gluten-free formula is suitable for sensitive individuals. Integrative Therapeutics is committed to transparency around sourcing and manufacturing processes, with extensive testing protocols that meet pharmaceutical standards. Healthcare practitioners frequently recommend this brand for both brain function and stress support.
What We Like
- Professional-grade Sharp-PS formula
- Highly bioavailable softgel format
- Soy-free, dairy-free, gluten-free
- Trusted by healthcare professionals
- 25+ years of quality manufacturing
What Could Be Better
- Premium pricing
- Smaller bottle size (60 softgels)
Bottom Line: The top choice when seeking professional-grade quality recommended by healthcare practitioners for stress and sleep support.
7. Allbe SleepCan with Melatonin & L-Theanine – Best Complete Sleep Formula
- PROUDLY CANADIAN MADE: Every bottle contains 90 capsules non-GMO, gluten free sleeping aid made in Canada in FDA registered facility adhering to GMP guideline; stored in airtight container & protected from light
For comprehensive sleep support, Allbe combines phosphatidylserine with melatonin and L-theanine for triple-action stress and sleep management.
This unique formula pairs phosphatidylserine with 5mg of melatonin for sleep onset and L-theanine for relaxation, creating a comprehensive approach to sleep support. The phosphatidylserine helps lower evening cortisol levels, while melatonin signals sleep time and L-theanine promotes calm without sedation. The convenient one-capsule daily serving makes this easier to incorporate into your bedtime routine. The two-pack provides 180 total capsules for a six-month supply.
What We Like
- Complete formula with three sleep-supporting ingredients
- One capsule convenience
- Addresses multiple sleep pathways
- Six-month supply (two bottles)
- Good value for combination formula
What Could Be Better
- PS dose not disclosed separately
- Contains melatonin which some prefer to avoid
Bottom Line: An excellent all-in-one option for those who want phosphatidylserine combined with proven sleep-supporting ingredients.
8. NOW Phosphatidylserine 300mg – Best Extra Strength Softgels
No products found.
NOW Foods delivers pharmaceutical-grade phosphatidylserine in easy-to-swallow softgels with excellent bioavailability.
This extra-strength formula provides 300mg of phosphatidylserine per softgel derived from soy lecithin. The softgel delivery system may enhance absorption compared to capsules, and the phospholipid complex includes other beneficial brain-supporting compounds. NOW Foods maintains strict GMP quality standards and tests every batch for purity and potency. The 50-softgel bottle provides nearly two months of support at the clinical dose.
What We Like
- Clinical 300mg dose per softgel
- Enhanced absorption in softgel form
- GMP-certified quality
- Includes supporting phospholipids
- Trusted brand with extensive testing
What Could Be Better
- Derived from soy (not suitable for soy allergies)
- Softgels may be less convenient for some
Bottom Line: A trusted extra-strength option in bioavailable softgel form for those who prefer this delivery method.
How to Choose the Best Phosphatidylserine for Sleep
When selecting phosphatidylserine specifically for sleep support, dosage is the most critical factor. Clinical studies demonstrating cortisol reduction and stress management typically use 300-400mg daily. For sleep support, taking this dose 30-60 minutes before bedtime allows the phosphatidylserine to help lower evening cortisol levels when they should naturally decline. Some people start with 100mg and gradually increase, while others with significant stress-related sleep issues may benefit from the full 300-400mg from the start.
The source of phosphatidylserine matters both for quality and dietary considerations. Sunflower-derived PS is soy-free and generally preferred for those with soy sensitivities or allergies. Soy-derived PS is also effective and often less expensive, but the source should be clearly labeled. Both sources provide the same active compound, though some argue sunflower-sourced PS may be cleaner due to fewer processing steps. Always choose products that clearly identify their PS source on the label.
Standardization and purity ensure you’re getting consistent, effective dosing. Look for products standardized to a specific percentage of phospholipids (often 20% or higher). This guarantees you’re receiving a concentrated, potent form rather than a weaker extract. Third-party testing certificates should confirm the actual PS content matches the label claim and verify the product is free from contaminants, heavy metals, and impurities.
Consider whether you want standalone phosphatidylserine or a combination sleep formula. Standalone PS gives you maximum flexibility to combine with other supplements as needed and adjust your dosage precisely. Combination formulas with melatonin, L-theanine, magnesium, or other sleep supporters can be convenient and may provide synergistic benefits, but make it harder to identify which ingredient is helping most.
Delivery format affects both convenience and absorption. Capsules are most common and convenient for most people. Softgels may offer enhanced bioavailability since phosphatidylserine is fat-soluble and softgels typically contain an oil base. Some people find softgels easier to swallow, while others prefer the smaller size of capsules. Choose based on your personal preference and any swallowing difficulties you may have.
Benefits of Phosphatidylserine for Sleep
Phosphatidylserine’s primary sleep benefit comes from its proven ability to reduce elevated cortisol levels. Cortisol is your body’s main stress hormone, and when it remains high in the evening (rather than naturally declining), it can prevent you from falling asleep and contribute to middle-of-the-night waking. Studies show that 300-400mg of phosphatidylserine can significantly lower evening cortisol, helping restore your natural cortisol rhythm where levels are high in the morning and low at night.
By managing stress hormones, phosphatidylserine addresses a root cause of sleep problems rather than just masking symptoms. Unlike sleep medications that force drowsiness, PS works with your body’s natural systems to create conditions more conducive to sleep. This means you’re more likely to fall asleep naturally, stay asleep through the night, and wake up feeling genuinely rested rather than groggy or hungover.
Research demonstrates that phosphatidylserine can improve various aspects of sleep quality. Studies show reductions in sleep latency (time to fall asleep), fewer nighttime awakenings, improved sleep efficiency, and better subjective sleep quality ratings. One study found that people taking PS reported feeling more refreshed upon waking and experienced less daytime fatigue, suggesting deeper, more restorative sleep cycles.
As a phospholipid naturally present in brain cell membranes, phosphatidylserine supports overall brain health and cognitive function. This means it not only helps with sleep but may also improve memory, focus, and mental clarity during the day. For people whose racing thoughts or mental hyperactivity interfere with sleep, PS’s cognitive benefits can help create a calmer mental state more conducive to rest. The supplement is non-habit forming and can be used long-term without developing tolerance.
Frequently Asked Questions
When should I take phosphatidylserine for sleep?
For sleep support, take phosphatidylserine 30-60 minutes before bedtime. This timing allows the supplement to begin lowering cortisol levels as you’re preparing for sleep. Some people prefer taking it right after dinner, while others take it as part of their bedtime routine. The key is consistency – taking it at the same time each evening helps reinforce your body’s natural cortisol rhythm.
How much phosphatidylserine should I take for sleep?
Clinical studies showing cortisol reduction and improved sleep typically use 300-400mg daily. Start with 100-200mg if you’re new to phosphatidylserine and assess your response over 1-2 weeks. If you don’t see improvements, gradually increase to 300mg. Some people with severe stress-related sleep issues may benefit from 400-500mg, but consult a healthcare provider before exceeding 400mg daily.
Does phosphatidylserine help with insomnia?
Phosphatidylserine can help with insomnia, particularly when elevated cortisol or stress is a contributing factor. It works best for people who struggle to fall asleep due to racing thoughts, feel “wired and tired,” or wake up during the night with an active mind. It may be less effective for insomnia caused by other factors like sleep apnea, restless leg syndrome, or circadian rhythm disorders.
Can I take phosphatidylserine with melatonin?
Yes, phosphatidylserine and melatonin can be safely combined and may work synergistically. PS helps lower cortisol to create conditions conducive to sleep, while melatonin directly signals your body that it’s time to sleep. This combination addresses two different sleep pathways. Start with lower doses of each and adjust based on response. Some people find this combination more effective than either supplement alone.
How long does phosphatidylserine take to work for sleep?
Some people notice sleep improvements within 3-5 days of starting phosphatidylserine, while others may need 2-3 weeks of consistent use to experience full benefits. The cortisol-lowering effects can begin relatively quickly, but it may take time for your body’s stress response patterns to normalize. For best results, take PS consistently for at least 2-4 weeks before deciding if it’s working for you.
Are there any side effects of phosphatidylserine?
Phosphatidylserine is generally very well-tolerated with minimal side effects. Some people may experience mild digestive upset, particularly when first starting or taking high doses. Other potential but uncommon side effects include headaches or difficulty sleeping (paradoxically, usually only at very high doses taken during the day). Start with a lower dose and take with food to minimize potential digestive issues.
Can I take phosphatidylserine long-term?
Yes, phosphatidylserine is safe for long-term use and is non-habit forming. Unlike many sleep medications, you won’t develop tolerance requiring increasing doses over time. Most studies showing benefits used PS for several months without issues. However, if you’re taking other medications or have health conditions, consult with a healthcare provider before long-term supplementation.
Will phosphatidylserine make me drowsy during the day?
Phosphatidylserine should not cause daytime drowsiness when taken before bed. In fact, by improving sleep quality, it may actually increase daytime alertness and energy. However, some people are sensitive to PS and may experience mild sedation if taking very high doses during the day. This is why it’s recommended to take PS in the evening for sleep support rather than throughout the day.
