Best Probiotics for SIBO Supplements (2026) – Top 10 Reviewed
Small intestinal bacterial overgrowth (SIBO) occurs when bacteria that normally live in the large intestine migrate to the small intestine, causing bloating, gas, and digestive discomfort. Finding the right probiotic can help restore balance to your gut microbiome and manage SIBO symptoms. This guide reviews the best probiotic supplements specifically formulated to support digestive health and combat bacterial overgrowth.
Our Top Picks at a Glance
- Best Overall: Ultra Spore Probiotic – soil-based strains for SIBO support
- Best Value: Prebiotics and Probiotics for Gut Health – synbiotic formula with prebiotics
- Best Premium: Metagenics UltraFlora Intensive Care – 20 billion CFU clinically tested
Quick Comparison
| Product | Key Ingredients | Form | Servings | Best For |
|---|---|---|---|---|
| Ultra Spore Probiotic | Bacillus strains | Capsules | 60 | Soil-based support |
| Metagenics UltraFlora | L. plantarum 20B CFU | Capsules | 30 | Clinical strength |
| Prebiotics & Probiotics | Multi-strain blend | Capsules | 60 | Synbiotic support |
| Synbiotic 3-in-1 | Pre/Pro/Postbiotics | Capsules | 60 | Complete formula |
| Physician’s Choice | 60B CFU 10 strains | Capsules | 30 | High potency |
| Lactose Intolerance Pills | Probiotic + enzymes | Capsules | 60 | Enzyme support |
| Probiotic Gummies 19-in-1 | 100B CFU gummies | Gummies | 180 | Easy to take |
1. Ultra Spore Probiotic – Best Overall for SIBO
- DIGESTIVE SUPPORT: Replenishes good bacteria and fights bad bacteria to support your digestive health with less gas, bloating, and discomfort. Your digestive health is key to your well-being, but it faces challenges every day from diet, pollutants in the environment, antibiotics, and more. That’s where a great probiotic can help.
- IMMUNE SUPPORT: 80% of your immune system lives in the gut! A healthy gut means healthy immunity. Our formula contains the potent, well-studied strains Bacillus clausii and Bacillus subtilis HU58 to support immunity and immune system responses.
- NATURE’S BEST PROBIOTICS: Spore strains are nature’s best design for probiotics. We use strains backed by research including Bacillus subtilis HU58, Bacillus clausii, and Bacillus coagulans, which are clinically proven to survive digestion. Many yogurts and other probiotic brands with up to 100 Billion CFUs (colony forming units) contain strains that aren’t made to survive digestion, like Lactobacillus and Bifidobacterium. With probiotics, choose quality over quantity every time.
- CLEAN, HIGH-QUALITY FORMULAS: All Natures Instincts probiotics are soy-free, gluten-free, dairy-free, GMO-free & vegetarian, with no artificial colors, flavors, binders or fillers. We DNA-Verify every bottle to ensure you are getting exactly what’s on the label. Sadly, not every probiotic can claim the same.
- NO REFRIGERATION NEEDED: Natures Instincts probiotics do not require refrigeration, so they are convenient at home or for travel. Since our bodies are roughly 98.6 °F, it only makes sense to choose a probiotic supplement that can withstand higher temperatures. If it needs to be refrigerated to stay alive, how will it survive the high temperature of your body when you digest it?
Ultra Spore Probiotic delivers soil-based Bacillus strains that are specifically beneficial for managing SIBO symptoms.
This formula features spore-forming Bacillus coagulans and Bacillus subtilis, which survive stomach acid to reach the small intestine where they can address bacterial overgrowth. These soil-based organisms help reduce bloating and gas while supporting healthy gut motility, a crucial factor in preventing SIBO recurrence.
What We Like
- Spore-forming strains survive stomach acid effectively
- Bacillus species specifically studied for SIBO management
- Helps reduce bloating and intestinal gas
- Supports gut motility to prevent bacterial stasis
What Could Be Better
- May take several weeks to see full benefits
- Higher price point than standard probiotics
Bottom Line: Ultra Spore Probiotic offers targeted soil-based strains that are ideal for managing SIBO and supporting long-term gut health.
2. Metagenics UltraFlora Intensive Care – Best Clinical Strength
- Provides targeted support for digestive and intestinal health with 20 billion CFU of the clinically tested Lactobacillus plantarum 299v strain—shown to help relieve occasional GI discomfort and bowel irritation*
- Supports healthy gut microbiome balance, regularity, and immune support while supporting colon comfort and maintaining intestinal barrier integrity*
- Formulated as a non-GMO, gluten-free, vegetarian probiotic in easy-to-swallow capsules; manufactured in a cGMP-certified facility and third-party tested for purity and potency*
- Certified B Corporation trusted by healthcare practitioners for over 40 years; science-backed probiotic formulation designed for reliable digestive comfort and daily gut support*
- As the #1 Doctor Recommended Professional Supplement Brand, Metagenics delivers clinically proven, precision-crafted formulas to support your health at its core—because true wellness starts with integrity, balance, and expertise
Metagenics delivers a clinically tested formula with 20 billion CFU of Lactobacillus plantarum specifically studied for digestive health.
This professional-grade probiotic contains a single, well-researched strain that has shown benefits for gut motility and reducing fermentation. L. plantarum helps prevent food and bacterial stasis in the digestive tract, addressing a root cause of SIBO.
What We Like
- Clinically tested Lactobacillus plantarum strain
- High potency at 20 billion CFU per capsule
- Enhances gut motility to prevent bacterial overgrowth
- Professional-grade quality from trusted brand
What Could Be Better
- Single-strain formula may not suit everyone
- Premium pricing
Bottom Line: A high-quality, clinically validated option for those seeking professional-grade SIBO support with proven strains.
3. Prebiotics and Probiotics for Gut Health – Best Synbiotic Formula
- PROBIOTIC AND PREBIOTIC CAPSULES: Probiotics are beneficial bacteria that help maintain a healthy balance in your gut. Prebiotics act as food for probiotics, to help them grow and thrive. A synbiotic combines probiotics and prebiotics to optimize gut health.*
- SUPPORT HEALTHY DIGESTION: With a high 20 billion CFU in every serving of prebiotic and probiotic, our high-quality probiotic prebiotic supplement is the well-rounded digestion aid to rebalance and support your digestive tract.*
- REDUCES BLOATING: MAV Nutrition’s Pre and Probiotics for women & men contain the most potent probiotic strains to promote regularity and digestive health. Lactobacillus Acidophilus & Bifidobacterium Bifidum are well-studied for supporting bloating relief for women and men.*
- MADE FOR YOUR MICROBIOME: A balanced microbiome is key to overall digestive and immune health. Pro-Pre’s symbiotic blend of pro and prebiotics for women & men can help maintain a healthy balance of gut microbiota.*
- NO REFRIGERATION NEEDED: Our daily synbiotic Probiotic and Prebiotic for women & men is formulated Non-GMO, Vegetarian, Gluten-Free, and manufactured in a GMP certified facility. It is third-party tested to meet the highest possible standards.
This synbiotic formula combines multiple probiotic strains with prebiotics to provide comprehensive digestive support for SIBO management.
The blend includes beneficial Lactobacillus and Bifidobacterium species along with prebiotic fiber to nourish good bacteria. This combination approach helps restore balance to the gut microbiome while addressing bloating and digestive discomfort.
What We Like
- Multi-strain formula for broader support
- Includes prebiotics to feed beneficial bacteria
- Addresses multiple aspects of gut health
- Good value for daily supplementation
What Could Be Better
- Prebiotics may cause initial gas in sensitive individuals
- May need gradual introduction
Bottom Line: An effective synbiotic option that combines probiotics and prebiotics for comprehensive SIBO support and gut health restoration.
4. Synbiotic 3-in-1 Prebiotics, Probiotics & Postbiotics
- PROBIOTICS AND PREBIOTICS FOR DIGESTIVE HEALTH: Our daily synbiotic is a 3-in-1 formula that meets the essential gut health needs of both men and women, containing probiotics for men digestive health and probiotics for women digestive health.
- GUT HEALTH SUPPLEMENTS: Featuring probiotics and prebiotics that aid in the production of digestive enzymes, our daily use probiotic blend maintains good gut bacteria diversity, supports digestion and helps provide bloating relief.
- ADVANCED FORMULA FOR GUT HEALTH: Our probiotic prebiotic capsules combine multiple strains of probiotics that fortify the growth and diversity of good gut bacteria. Our formula is an essential blend of men's and women's probiotics for gut health.
- IMMUNE SUPPORT AND BLOATING RELIEF: Our clinically-proven postbiotic not only enhances immune function but also offers bloating relief for men and women, acting as a powerful antioxidant protector. Immune supporting benefits begin to work within 2 hours of taking.
- PURITY AND QUALITY: As a premium gut health supplement, our biome focused formula is non-GMO, third-party tested, and combines both prebiotics and probiotics for women and men, ensuring clean ingredients for your digestive wellness.
This comprehensive formula delivers prebiotics, probiotics, and postbiotics in one complete supplement for digestive and immune support.
The 3-in-1 approach provides live strains, the fiber they need to thrive, and beneficial postbiotic metabolites. This complete system supports gut barrier function and helps manage SIBO symptoms by addressing multiple aspects of digestive health.
What We Like
- Complete 3-in-1 formula with pre/pro/postbiotics
- Supports gut barrier integrity
- Comprehensive digestive and immune support
- Convenient once-daily dosing
What Could Be Better
- May be too comprehensive for some beginners
- Contains multiple components that could cause initial adjustment
Bottom Line: A thorough approach to gut health that combines prebiotics, probiotics, and postbiotics for comprehensive SIBO management.
5. Physician’s Choice Probiotics 60 Billion CFU
- Max Strength General Purpose Probiotic: Our non-refrigerated probiotic is designed to support digestive health & gut health. A great choice for those looking to support a diverse healthy microbiome w/ 60B CFU - Probiotics for Women & Men alike. One Month Supply
- Support Your Gut: Our probiotic contains 10 diverse high-quality probiotic strains and organic prebiotics - synergistically working together to support your gut health. Expertly crafted to support occasional constipation, diarrhea, gas & bloating!
- Survives the Gut: From start to finish - this probiotic is designed to survive the gut & maximize the colonization of our strains. We use a shelf-stable bottle, acid-resistant capsules, and 60 Billion Colony forming units (CFU) to achieve this!
- Backed By Science - Our probiotics are crafted based on scientific research. We have partnered with a network of expert physicians to help review our products & research. We strive to educate & help you with informed decisions regarding your health.
- Safety Assured Standard of Quality: Our 60B probiotic is 3rd-party tested for purity and potency. Each bottle is manufactured with love & care in the USA with strict quality control - using imported and domestic ingredients.
Physician’s Choice delivers 60 billion CFU with 10 different strains plus organic prebiotics for maximum gut support.
This high-potency formula includes key strains like Bifidobacterium lactis and Lactobacillus acidophilus that have been studied for their benefits in gut motility and reducing SIBO symptoms. The acid-resistant capsules ensure strains survive to reach the intestines.
What We Like
- Very high potency at 60 billion CFU
- 10 diverse probiotic strains for broad support
- Includes organic prebiotics
- Acid-resistant capsules for survival
What Could Be Better
- High CFU count may be too strong initially
- Some may need to start with half dose
Bottom Line: A potent multi-strain formula backed by research and designed to survive the digestive tract for effective SIBO support.
6. Lactose Intolerance Pills with Probiotic
- Propriety Strain Formula, Non-GMO, Supports Lactose Digestion: Designed to produce lactase enzymes that support the breakdown of lactose. Designed as a digestive nutritional supplement for ongoing lactase support. Make dairy days easier.
- Bactose Doesn't Contain Lactase, It's Designed to Produce It: Unlike standard lactose intolerance pills that supply lactase enzyme directly, Bactose introduces a specialized L. acidophilus probiotic strain designed to produce lactase enzymes in the gut. This probiotic-based approach is what makes Bactose a uniquely formulated dairy digestion supplement.
- Enjoy Dairy Again: Dairy is one of the most nutrient-rich food groups available, providing essential vitamins and minerals. Bactose is a dairy digestion supplement designed to support your body’s ability to enjoy the foods you love. Whether it’s cheese, ice cream, or milk — Bactose is the dairy pill designed to help you get back to enjoying it all.
- Probiotic-Powered Lactase Support: Bactose contains our proprietary L. acidophilus BL21A probiotic, designed to produce lactase enzymes that support the natural digestion of lactose. A smarter alternative to daily lactose pills and lactase enzyme supplements.
- How to Take Bactose: Take one capsule twice daily for 7 days. Repeat monthly for ongoing support. Unlike other dairy pills for lactose intolerance that require dosing before every meal, Bactose is designed as a once-a-month, 7-day course.
This unique formula combines probiotics with lactase enzymes for dual digestive support.
The probiotic strains help address bacterial imbalance while the lactase enzyme supports dairy digestion, making it ideal for those with SIBO who also struggle with lactose intolerance. The combination approach provides both immediate enzyme support and long-term probiotic benefits.
What We Like
- Combines probiotics with digestive enzymes
- Addresses multiple digestive issues
- Helps with dairy digestion and bacterial balance
- Dual-action formula for comprehensive support
What Could Be Better
- More specific to lactose issues
- May not be needed if dairy isn’t consumed
Bottom Line: An innovative combination product that addresses both bacterial imbalance and lactose intolerance for dual digestive support.
7. Probiotic Gummies 19-in-1 with 100 Billion CFU
- 19 IN 1 Pre Post Probiotics Gummies: Our 19 IN 1 probiotic gummies combine 100 Billion CFU probiotics, 1000mg postbiotics, and 5g prebiotics in a scientifically balanced formula, supporting general digestive wellness and gut microbiota balance. 180-gummies pack, containing 60 individual pouches. These probiotics for women men gummies are ideal for daily use and offer a convenient way to maintain gut wellness.*
- Gut & Digestion Health: Our probiotic gummies with 100 Billion CFU probiotics and 5g prebiotics to supports general digestive wellness, gut microbiota balance and gut wellness. 19 in 1 prebiotic probiotic postbiotic gummies may support digestive comfort, supporting the growth of beneficial gut bacteria for a balanced digestive system.*
- Immune & Overall Health: Supports overall wellness and immune function with postbiotics and probiotics. 19 in 1 pre, post, and probiotics for women and men gummies promotes maintaining a balanced microbiota for digestive wellness.*
- Time-Release Formula, Shelf-Stable: Our probiotic gummies feature a time-release formula to maintain probiotic potency and provide high absorption, with stable shelf-life and no refrigeration needed. 19 in1 pre post probiotics gummies designed for convenience and comprehensive benefit, perfect for whole family and busy individuals.*
- Sugar-Free, Vegan, Delicious: Our probiotic gummies are sugar-free, vegan-friendly gummies with a delicious orange flavor, easy to chew, available in a convenient pack of 180 gummies, including 60 small packs, perfect for whole family or long-term use, and easy to carry anytime, anywhere. Each serving contains 3 gummies, providing a 60-day supply for your daily wellness routine.
These gummies deliver an impressive 100 billion CFU with 19 different strains in a delicious, easy-to-take format.
The gummy delivery system makes daily probiotic supplementation enjoyable while providing prebiotics, probiotics, and postbiotics. The diverse strain profile includes key species for gut motility and bacterial balance that are beneficial for SIBO management.
What We Like
- Very high CFU count at 100 billion
- 19 diverse probiotic strains
- Easy-to-take gummy format
- Includes prebiotics and postbiotics
What Could Be Better
- Contains small amount of sugar
- May be less stable than capsules
Bottom Line: A convenient and potent gummy option that makes taking high-dose probiotics enjoyable while supporting SIBO management.
How to Choose the Best Probiotic for SIBO
When selecting a probiotic for SIBO, the strain matters more than the CFU count. Research shows that specific strains have documented benefits for managing bacterial overgrowth and related symptoms. Look for products containing Bacillus species (especially B. coagulans and B. subtilis), Lactobacillus plantarum, Bifidobacterium lactis, and Saccharomyces boulardii, as these have shown particular promise in clinical studies.
Soil-based probiotics deserve special consideration for SIBO because their spore-forming nature allows them to survive stomach acid and reach the small intestine where bacterial overgrowth occurs. These hardy strains can colonize effectively and help restore proper bacterial balance without feeding the existing overgrowth.
Consider whether you need a single-strain or multi-strain formula. While some research supports targeted single-strain approaches like Lactobacillus plantarum for motility, other studies show benefits from diverse multi-strain formulas that address SIBO through multiple mechanisms. Your choice may depend on your specific SIBO type and symptoms.
Pay attention to delivery systems and additional ingredients. Acid-resistant capsules or delayed-release technology helps ensure probiotics survive to reach the intestines. Some formulas include prebiotics, which can be beneficial but may cause initial gas in sensitive individuals. Start with lower doses and gradually increase to minimize digestive discomfort.
Timing matters when introducing probiotics during SIBO treatment. Many practitioners recommend waiting until after antimicrobial treatment before starting probiotics, though some gentle strains can be used during treatment. Work with a healthcare provider to determine the best timing and dosage for your specific situation.
Benefits of Probiotic Supplements for SIBO
Probiotics help manage SIBO by supporting gut motility, one of the key factors in preventing bacterial overgrowth. When the migrating motor complex (MMC) functions properly, it sweeps bacteria from the small intestine into the large intestine where they belong. Certain probiotic strains, particularly Bifidobacterium lactis, have been shown to enhance gut motility and support this natural cleansing mechanism.
By competing with pathogenic bacteria for nutrients and attachment sites, beneficial probiotics help restore balance to the gut microbiome. This competitive exclusion reduces the overgrowth of problematic bacteria while strengthening the gut barrier. Strains like Lactobacillus plantarum produce lactic acid that creates an environment less favorable for harmful bacteria while supporting beneficial species.
Probiotics support the reduction of inflammation and improvement of gut barrier function, both of which are often compromised in SIBO. Research shows that specific strains produce short-chain fatty acids and other metabolites that strengthen the intestinal lining, reduce permeability, and modulate immune responses in the gut.
Many people with SIBO experience relief from uncomfortable symptoms like bloating, gas, and abdominal discomfort when using targeted probiotic strains. The anti-inflammatory and barrier-supporting effects of probiotics help address these symptoms at their root cause rather than just masking them temporarily.
Frequently Asked Questions
Can probiotics make SIBO worse?
Some people with SIBO may experience temporary worsening of symptoms when starting probiotics, especially with high CFU counts or certain lactobacillus strains. This is why many practitioners recommend soil-based probiotics like Bacillus species, which are less likely to contribute to overgrowth. Start with low doses and increase gradually, and consider working with a healthcare provider to determine the right timing and strains for your situation.
What’s the difference between soil-based and regular probiotics for SIBO?
Soil-based probiotics contain spore-forming bacteria like Bacillus coagulans and Bacillus subtilis that can survive stomach acid and reach the small intestine more effectively. These strains are less likely to contribute to bacterial overgrowth because they don’t ferment and produce gas as readily as some lactobacillus strains. Regular probiotics contain lactobacillus and bifidobacterium species, which can still be beneficial but may need to be introduced more carefully.
How long does it take for probiotics to help with SIBO?
Most people notice some improvement in SIBO symptoms within 2-4 weeks of consistent probiotic use, though full benefits may take 2-3 months. The timeline depends on the severity of your SIBO, which strains you’re using, and whether you’re combining probiotics with other treatments like antimicrobials or dietary changes. Consistency is key for allowing beneficial bacteria to colonize and restore balance.
Should I take probiotics during or after SIBO treatment?
The optimal timing depends on your treatment protocol and individual response. Some practitioners recommend waiting until after antimicrobial treatment to start probiotics, while others suggest introducing gentle strains like Saccharomyces boulardii during treatment. Soil-based probiotics are often well-tolerated during treatment. Work with your healthcare provider to determine the best approach for your specific case.
What strains are best for hydrogen vs methane SIBO?
For hydrogen SIBO, focus on strains that improve motility like Bifidobacterium lactis and Lactobacillus plantarum. For methane SIBO (now called IMO), Saccharomyces boulardii and certain Bacillus species may be more beneficial. Multi-strain formulas can address both types, though targeted single-strain approaches based on breath test results may be more effective in some cases.
Can I take probiotics with SIBO antibiotics or antimicrobials?
Saccharomyces boulardii, a beneficial yeast, can be safely taken with antibiotics since it’s not affected by antibacterial medications. For bacterial probiotics, it’s generally best to separate them from antibiotics by at least 2 hours. Some soil-based probiotics are resistant enough to be taken during antimicrobial treatment, but check with your healthcare provider for specific recommendations.
Do I need prebiotics with my probiotic for SIBO?
Prebiotics can be beneficial but should be introduced cautiously with SIBO. While they feed beneficial bacteria, they can also cause gas and bloating in sensitive individuals. If you have active SIBO, you may want to start with probiotics alone and add prebiotics later once symptoms improve. Some formulas include low amounts of prebiotics that are generally well-tolerated.
Are probiotic gummies as effective as capsules for SIBO?
Probiotic gummies can be effective for SIBO, though they may contain small amounts of sugar that could potentially feed bacteria. High-quality gummies with protective coatings can deliver probiotics effectively. Capsules, especially those with acid-resistant technology, may offer better strain survival and stability. Choose based on what you’ll take consistently, as regular use is most important.
