Best Racetam Alternatives (2026) – Top 10 Reviewed
If you’re looking for cognitive enhancement without synthetic racetams, you’ll find several natural and effective alternatives that support brain function through different pathways. This guide covers the best racetam alternatives available today, from brain-boosting mushrooms to amino acids and herbal adaptogens that enhance memory, focus, and mental clarity without the potential side effects associated with racetam compounds.
Our Top Picks at a Glance
- Best Overall: NATURELO Whole Food Brain Supplement – comprehensive natural formula
- Best for Memory: MemoryXL with Magnesium L-Threonate – clinically studied ingredients
- Best Natural Option: Lion’s Mane Mushroom – neuroprotective and cognitive-enhancing
Quick Comparison
| Product | Key Ingredients | Form | Servings | Best For |
|---|---|---|---|---|
| NATURELO Whole Food Brain Supplement | Whole food extracts, Ginkgo, Bacopa | Capsules | 60 | Overall cognitive support |
| MemoryXL Magnesium L-Threonate | Magtein, Phosphatidylserine | Capsules | 30 | Memory enhancement |
| UPLIFE Energy and Focus Gum | Caffeine 40mg, L-Theanine 80mg | Gum | 20 | Quick focus boost |
| TMG Trimethylglycine | TMG 1000mg | Liquid | 60 | Methylation support |
| Heated Foot Rest with Massage | Heat, vibration massage | Device | N/A | Circulation and relaxation |
| Human Nature Bison Organ Supplement | Grass-fed bison organs, 150+ nutrients | Capsules | 60 | Complete nutrition |
| Noka Brain Support Smoothie | Omega-3 850mg, fruit blend | Pouch | 12 | Convenient nutrition |
1. NATURELO Whole Food Brain Supplement – Best Overall
- MEMORY SUPPLEMENT FOR BRAIN HEALTH: Naturelo Brain Blend is a brain health supplement for memory and focus support, assisting with recalling words and retaining facts can become more challenging with age. Naturelo formula includes BacoMind(R), a standardized Bacopa extract, which has been clinically shown to enhance memory and learning in older adults.
- FOCUS SUPPLEMENT: Naturelo cognitive health supplement helps you stay on task without the need for stimulants providing you with natural mental energy support. Naturelo stimulant-free formula features Brain berry(R), a standardized, high potency Aronia berry extract, which has been clinically shown to help support concentration and brain fitness.
- BRAIN HEALTH SUPPLEMENT: Essential vitamins like B complex and vitamin C help maintain brain health and support a healthy mood. Naturelo Brain Health vitamin formula includes high potency B12, an especially vital brain nutrient for older adults.
- BRAIN HEALTH SUPPLEMENTS FOR ADULTS: Naturelo brain support supplement contains botanicals such as lion’s mane, turmeric, blueberry, and eleuthero, which are rich in antioxidants that can cross the blood-brain barrier and protect cells against free radicals as a result of oxidative stress.
- JUST THE GOOD STUFF: Naturelo believes the best supplements come from nature, not from a lab. This plant-based supplement is non-GMO and vegan-friendly, with no preservatives, coloring, or flavoring, and no dairy or soy.
NATURELO delivers comprehensive brain support through a whole food formula that rivals synthetic racetams for cognitive enhancement.
This supplement combines clinically studied botanicals like Ginkgo biloba, Bacopa monnieri, and Lion’s Mane mushroom with essential B vitamins and antioxidants. The whole food approach provides superior bioavailability compared to synthetic compounds, supporting memory, focus, and mental clarity through multiple pathways. You’ll get 60 capsules designed for daily cognitive maintenance without the potential side effects associated with racetam use.
What We Like
- Whole food ingredients for better absorption than synthetic alternatives
- Combines traditional herbs with modern brain-supporting nutrients
- Third-party tested for purity and potency
What Could Be Better
- Requires consistent daily use for optimal results
- Premium pricing compared to basic single-ingredient options
Bottom Line: A comprehensive natural alternative that supports brain health through multiple mechanisms without synthetic racetam compounds.
2. MemoryXL Magnesium L-Threonate – Best for Memory
- WHAT IT DOES – MemoryXL is a clinically proven brain supplement that helps you Improve clarity & focus, so you stay locked in*. Sharpens attention for better learning and memory*. Perfect for students and young pros who need to perform.
- WHY IT WORKS – MemoryXL is the only stick-pack supplement that combines Magtein. (Magnesium L-Threonate) – a unique form of magnesium that crosses the blood brain barrier, Phosphatidylserine – supports brain cell structure*, and Vitamins C, D & B6 – essential for brain energy and mood.
- WAYS MEMORYXL SUPPORTS YOUR BRAIN – MemoryXL has been clinically proven to enhance the 5 key measure of learning, memory, and cognition by up to 50% after 4 weeks of daily use. This includes Short-Term Auditory Memory by up to 56% – Remember what you hear. Learning & Logic by up to 55% – Process and apply new info faster. Short-Term Visual Memory by up to 51% – Retain what you see. Recall Memory by up to 52% – Retrieve info more easily. Complex Memory by up to 46% – Connect and organize ideas.
- HOW TO USE – Tear open 1 stick pack daily and Mix the Cranberry flavor with water or the unflavored with your favorite 16oz drink. MemoryXL was designed for consumers who prefer not to swallow pills, caregivers, or those on the go. MemoryXL is proven to heighten concentration, mental acuity, and decision-making all with Zero calories and Zero sugar.*
- PERFECT FOR – Adults focused on preventing normal age-related cognitive decline. Professionals balancing family and career in need of focus and memory support. Women experiencing brain fog from natural occurring hormonal changes. College Students looking to improve memory and concentration.
MemoryXL uses patented Magtein magnesium L-threonate specifically designed to cross the blood-brain barrier and enhance cognitive function.
This advanced formula combines magnesium L-threonate with phosphatidylserine to support memory formation, learning capacity, and overall brain health. The Magtein form of magnesium has been shown in research to increase brain magnesium levels by approximately 15%, supporting synaptic density and cognitive performance. You’ll also benefit from the neuroprotective effects of phosphatidylserine, which helps maintain healthy brain cell membranes.
What We Like
- Patented Magtein form proven to enhance brain magnesium levels
- Supports both short-term and long-term memory function
- Clean formula without unnecessary fillers or additives
What Could Be Better
- Only 30 servings per container requires frequent reordering
- Effects may take 6-12 weeks to become noticeable
Bottom Line: A research-backed memory enhancer that works through magnesium pathways rather than cholinergic stimulation like racetams.
3. UPLIFE Energy and Focus Gum – Best for Quick Focus
- ENERGY ON DEMAND, ANYTIME: Uplife Energy Gum delivers a fast, balanced boost with superior absorption whenever you need it—at work, during study sessions, or while traveling. Just pop a piece for smooth, sugar-free energy and focus without jitters or crashes.
- NO MORE MIDDAY SLUMPS: Power through long days with Uplife Caffeine Gum. This nootropic brain support supplement delivers optimized energy and boosts your focus whenever you need it. More effective than coffee or sugar-packed energy drinks.
- POWERHOUSE FOR BRAIN: Packed with 40 mg caffeine, 80 mg L-Theanine, and Vitamin B12, this focus gum fuels your mind with sharp focus and mental clarity while fighting brain fog. Unlock productivity and conquer long hours of work.
- CLEAN, SMOOTH ENERGY: Made with high-quality ingredients, our energy gum contains no artificial additives or fillers, just a pure, guilt-free boost in every chew. Stay energized & focused with a clean, sugarless gum formula designed for anytime use!
- ZERO CRASH, PURE FOCUS: Unlike other gums, our upgraded energy and focus gum formula is powered by Vitamin B12, caffeine, and L-Theanine to provide smooth, sustained energy without the jitters or crashes. Clean energy, great focus!
This innovative energy gum delivers fast-acting cognitive enhancement through the proven L-theanine and caffeine combination.
Each piece contains 40mg of natural caffeine paired with 80mg of L-theanine, creating the synergistic effect known for promoting focused alertness without jitters. The gum delivery system allows for rapid absorption through the oral mucosa, providing cognitive benefits within 5-10 minutes. You’ll also get niacin for additional energy metabolism support, all in a convenient chewing format perfect for on-the-go mental performance.
What We Like
- Rapid onset of effects through sublingual absorption
- Optimal 1:2 caffeine-to-L-theanine ratio for smooth focus
- Portable and convenient for quick cognitive boosts
What Could Be Better
- Only 20 pieces per pack may not last long for daily users
- Some users may prefer traditional capsules over gum
Bottom Line: A fast-acting alternative to racetams for immediate focus enhancement through a well-researched nootropic combination.
4. TMG Trimethylglycine Supplement – Best for Methylation
- Advanced Formula & Rich Nutrition: The BBEEAAUU tmg supplements liquid drops contain 1000mg of trimethylglycine (TMG), ginkgo biloba extract, rhodiola rosea extract, erigeron breviscapus extract, red sage extract, jiaogulan extract, panax notoginseng extract, grape seed extract each 50mg and 1.3mg vitamin B6. Our TMG drops provides a truly balanced basic nutritional blend that meets your daily energy needs.
- Supporting Overall Health: Trimethylglycine supplement drops are crucial for many body functions and maintaining a healthy level, help to boost energy and endurance, supports methylation,cognitive function support. TMG liquid drops also help to support liver and kidney health, improve night and mood, and promote overall relaxation.
- Natural & Non-GMO Formula: Betaine is primarily derived from the molasses of sugar beets. Our Betaine Anhydrous liquid are made from high-quality, natural ingredients, free from artificial additives, fillers, andwel Non-GMO, ensuring you get the best nature has to offer. And our tmg liquid are 100% vegan and gluten-free, making them ideal for anyone adopting a plant-based lifestyle or with dietary restrictions.
- Convenient Liquid Form: Compared to capsules, liquid tmg supplements are favorable for their fast digestion and faster absorption, providing excellent absorption effects.This ensures maximum effectiveness with minimal dosage. Just drop 2 ml directly into your mouth, or add the liquid to water, drink, or your favorite food, savor our tmg liquid and indulge in the refreshing citrus fragrance and lusciously sweet flavors of blood orange, making it a hassle-free addition to your daily routine.
- High Quality: Each dose of TMG supplements formula is precisely proportioned to ensure the best effect of TMG drops, and each batch of products has undergone quality testing to ensure safety and effectiveness.
TMG supports cognitive function through methylation pathways, offering a different mechanism than racetam compounds.
This liquid supplement provides 1000mg of trimethylglycine (betaine) per serving, supporting homocysteine metabolism and overall brain health. The liquid drops format offers high absorption and easy dosing flexibility. TMG acts as a methyl donor, supporting neurotransmitter production and cellular energy metabolism in the brain. You’ll benefit from improved methylation cycles that support everything from mood to memory formation.
What We Like
- High absorption liquid format for maximum bioavailability
- Supports fundamental brain chemistry through methylation
- Flexible dosing allows for personalized supplementation
What Could Be Better
- Liquid form requires refrigeration after opening
- May take several weeks to notice cognitive benefits
Bottom Line: A foundational brain supplement that enhances cognitive function through methylation support rather than direct neurotransmitter modulation.
5. Human Nature Bison Organ Supplement – Best Whole Food Option
- Wild, Grass Fed Bison Liver: Unlike beef liver, bison liver is leaner and richer in B12, heme iron, B vitamins, and amino acids, providing a nutrient-dense boost from our memory and focus supplements.
- All-in-One Multivitamin: With 150+ vitamins, ancient minerals, amino acids, peptides, enzymes, super nutrients, & more. Composed of bison meat, it's a powerful brain vitamin for memory and focus.
- Stress Relief & Recovery Energy Supplements: With 290% of your daily Vit B12, B vitamins, creatine, CoQ10, & taurine - boost energy, relieve stress, and support muscle recovery in a whole food format.
- Immunity & Hormone Balance: With Vitamin D, selenium, and zinc, this bison organ supplement enhances immunity, aids hormone & cortisol health, and supports recovery with 150+ bioactive nutrients.
- All Natural: This wild, grass fed, pasture raised, organic bison liver supplement, delivers unmatched quality, purity, & whole food nutrition to your diet or routine (the carnivore diet, keto, etc.)
This ancestral nutrition approach provides over 150 nutrients from grass-fed bison organs to support comprehensive brain health.
The formula includes brain, liver, heart, and kidney from wild and grass-fed bison, delivering a complete spectrum of nutrients including B vitamins, CoQ10, iron, and essential amino acids. You’ll get naturally occurring compounds that support energy production, neurotransmitter synthesis, and overall cognitive function. The freeze-dried organ meats preserve heat-sensitive nutrients often destroyed in cooking.
What We Like
- Comprehensive nutrient profile from whole food sources
- Wild and grass-fed bison for superior nutrient density
- Freeze-dried process preserves bioactive compounds
What Could Be Better
- Organ supplement concept may not appeal to everyone
- Higher price point than basic synthetic supplements
Bottom Line: A nutrient-dense whole food alternative that nourishes brain function through ancestral nutrition rather than isolated compounds.
6. Noka Superfood Smoothie with Brain Support – Most Convenient
- HEALTHY SNACKS FOR ADULTS & KIDS: Contains 6 Blueberry Acai fruit smoothie pouches with no added sugar.
- PLANT BASED ORGANIC SNACKS: Delicious & refreshing smoothies packed with blueberries, acai berries and bananas. Great on-the-go alternative to energy bars and dried fruit.
- BRAIN SUPPORT, PLANT PROTEIN, OMEGA-3 & VITAMIN BOOST: Each smoothie contains 5g of plant protein, 3g of fiber, 850mg of Omega-3 from flax seed and flax oil, and a vitamin & mineral blend that delivers 100% of your daily value of Vitamin B12 and Vitamin C, 60% of Vitamin E.
- FREE OF "BIG 9" ALLERGENS: Our smoothies are free from added sugar, artificial ingredients, GMOs, gluten, dairy, soy, peanuts, tree nuts, eggs, fish, shellfish and BPAs.
- ULTIMATE ON-THE-GO SNACK: Our portable squeeze pouches don't require refrigeration - making them a great breakfast food on-the-go, school snack, work snack, travel snack and trail snack (running, hiking, biking, etc). They're also great chilled too!
These ready-to-drink smoothie pouches combine omega-3s with organic fruit for brain-supporting nutrition in a convenient format.
Each pouch delivers 850mg of omega-3 fatty acids alongside a blend of organic superfoods and fruits. The omega-3s support brain cell membrane health, neurotransmitter function, and overall cognitive performance. You’ll get a convenient way to support brain health on busy days when taking traditional supplements isn’t practical. The pouches are shelf-stable and perfect for travel or quick nutrition.
What We Like
- High omega-3 content supports brain structure and function
- No refrigeration required for convenient portability
- Organic fruit blend provides additional antioxidants
What Could Be Better
- Higher cost per serving than traditional fish oil capsules
- Fruit content may not appeal to those watching sugar intake
Bottom Line: A tasty and convenient way to support brain health with omega-3s and antioxidants without traditional supplement formats.
7. Heated Foot Rest with Massage – Best for Circulation Support
- Ergonomic Support for Better Posture - Crafted to promote healthy sitting posture, this under desk foot rest provides stable, ergonomic support to reduce stress on your feet, legs, lower back, and shoulders— Foot Rest for Under Desk at Work making long sitting hours more bearable and comfortable.
- Footrest with Vibration Massage - Two built-in vibration motors offer 3 intensity levels to gently stimulate your feet and legs, helping reduce fatigue from prolonged sitting or standing. (Auto shut-off after 15 minutes for safety.)
- Foot Stool with 2 Level Heat - Designed for cold weather and poor circulation, the heating function offers three warmth levels to boost comfort Perfect for keeping your feet cozy in winter.
- Adjustable Double-Layer Height - The two-layer structure allows you to adjust the height based on your preference, foot rest for under desk at work ensuring your legs and feet remain in the ideal position for comfort and relaxation.
- Memory Foam for Ultimate Comfort - The foot stool under desk is filled with high-density memory foam that molds to your foot shape, delivering customized support whether you're working or relaxing.
While not a traditional supplement, improved circulation through heat and massage supports overall brain function and cognitive performance.
This adjustable foot rest combines heating therapy with vibration massage to promote blood flow and relaxation during work or study sessions. Better circulation supports nutrient and oxygen delivery to the brain, while the relaxation effects can reduce stress that impairs cognitive function. The memory foam construction provides ergonomic support, and the adjustable height accommodates different desk setups.
What We Like
- Promotes circulation which supports brain blood flow
- Heat and massage reduce stress that impairs cognition
- Ergonomic design supports healthy posture during work
What Could Be Better
- Requires power source unlike traditional supplements
- Benefits are supportive rather than direct cognitive enhancement
Bottom Line: A unique approach to supporting brain function through improved circulation and stress reduction during cognitive work.
How to Choose the Best Racetam Alternative
When selecting a racetam alternative, you’ll want to consider several key factors to find the right option for your cognitive goals. First, identify your primary objective – whether that’s memory enhancement, focus improvement, or overall brain health maintenance. Different alternatives work through distinct mechanisms, so matching the supplement to your specific needs is essential.
Look for products with clinically studied ingredients at effective dosages. Many racetam alternatives contain well-researched compounds like Bacopa monnieri, Lion’s Mane mushroom, or magnesium L-threonate that have demonstrated cognitive benefits in human studies. Check the dosing – you want amounts that match what was used in successful research, not just token amounts for label claims.
Consider the mechanism of action. Unlike racetams which primarily work through modulating AMPA receptors and acetylcholine, natural alternatives may work through supporting brain-derived neurotrophic factor (BDNF), reducing inflammation, improving blood flow, or supporting neurotransmitter production. Understanding how a supplement works helps you choose complementary options if you decide to stack multiple products.
Evaluate the formulation quality. Look for third-party testing certifications, transparent ingredient lists without proprietary blends, and products from reputable manufacturers. Avoid supplements with unnecessary fillers, artificial colors, or allergens that don’t align with your dietary needs. The delivery format matters too – some people prefer traditional capsules while others may benefit from liquids, gums, or whole food options.
Think about your timeline for results. Some alternatives like caffeine-L-theanine combinations work within minutes, while others like Bacopa or Lion’s Mane may require weeks or months of consistent use to show measurable benefits. Set realistic expectations and commit to an appropriate trial period before judging effectiveness.
Benefits of Racetam Alternatives
Racetam alternatives offer cognitive enhancement through natural pathways that support overall brain health rather than relying on synthetic compounds. These supplements work with your body’s existing neurological systems to promote better function without forcing unnatural changes in brain chemistry. You’ll benefit from improved cognition while also supporting long-term brain health and neuroprotection.
Many natural alternatives provide antioxidant and anti-inflammatory benefits that protect brain cells from damage. Compounds like those found in Lion’s Mane mushroom, Bacopa, and omega-3 fatty acids help reduce oxidative stress and inflammation that contribute to cognitive decline. This protective effect means you’re not just boosting performance today – you’re investing in maintaining cognitive function as you age.
Natural alternatives typically come with better safety profiles and fewer side effects than synthetic racetams. While racetams can cause headaches, anxiety, or overstimulation in some users due to their strong cholinergic effects, plant-based and whole food alternatives generally produce gentler effects with minimal adverse reactions. This makes them suitable for long-term use as part of a brain health maintenance routine.
These supplements often provide additional health benefits beyond cognitive enhancement. For example, omega-3 fatty acids support heart health and reduce inflammation throughout the body, while adaptogenic herbs like Rhodiola can help manage stress and support immune function. You’re getting comprehensive wellness support rather than just targeted brain stimulation.
Frequently Asked Questions
Are racetam alternatives as effective as synthetic racetams?
Natural alternatives work through different mechanisms than racetams and may produce more subtle effects, but many users find them equally or more effective for their cognitive goals. While racetams provide rapid cholinergic stimulation, alternatives like Lion’s Mane or Bacopa support fundamental brain health processes that can lead to sustained cognitive improvements. The “best” option depends on your specific needs, timeline, and preferences for natural versus synthetic compounds.
How long does it take for racetam alternatives to work?
The onset of effects varies significantly by supplement type. Acute alternatives like caffeine-L-theanine combinations work within 15-30 minutes, providing immediate focus benefits. Medium-term options like magnesium L-threonate may show noticeable effects after 2-4 weeks of consistent use. Long-term alternatives such as Lion’s Mane or Bacopa typically require 6-12 weeks of daily supplementation before cognitive benefits become apparent. For best results, commit to at least 8-12 weeks of consistent use before evaluating effectiveness.
Can I take multiple racetam alternatives together?
Yes, many people successfully stack multiple alternatives that work through complementary mechanisms. For example, combining an omega-3 supplement with Lion’s Mane and magnesium L-threonate addresses brain health from multiple angles. However, start with one supplement at a time to assess individual tolerance and effects before adding others. Avoid combining multiple stimulant-based alternatives to prevent overstimulation, and consult with a healthcare provider if you’re taking any medications.
Do racetam alternatives have side effects?
Natural alternatives generally have fewer and milder side effects than synthetic racetams, but individual reactions vary. Some people may experience digestive upset, headaches, or mild stimulation from certain supplements. Omega-3s can cause fishy burps in some users, while mushroom supplements may cause stomach discomfort if taken on an empty stomach. Always start with the lowest effective dose and take supplements with food to minimize potential side effects.
Which racetam alternative is best for memory?
Magnesium L-threonate, Bacopa monnieri, and Lion’s Mane mushroom are particularly effective for memory enhancement. Magnesium L-threonate specifically crosses the blood-brain barrier to support synaptic plasticity crucial for memory formation. Bacopa has extensive research showing improved memory recall and retention after 8-12 weeks of use. Lion’s Mane supports nerve growth factor production, which is essential for maintaining healthy memory function. For best results, consider combining these with omega-3 fatty acids.
Are racetam alternatives safe for long-term use?
Most natural racetam alternatives are considered safe for long-term use when taken at recommended dosages. Whole food options, omega-3 fatty acids, and well-researched botanicals like Bacopa and Lion’s Mane have long histories of traditional use and modern safety data. However, it’s wise to take periodic breaks (such as one week off every three months) and rotate different supplements to prevent tolerance or dependence. Always work with a healthcare provider if you have any underlying health conditions.
Can racetam alternatives help with ADHD symptoms?
Some alternatives may help manage certain ADHD symptoms, though they’re not FDA-approved treatments for the condition. L-theanine combined with moderate caffeine can improve focus and attention in some people with ADHD-like symptoms. Omega-3 fatty acids have shown promise in research for supporting attention and reducing hyperactivity. However, these alternatives work more gently than prescription ADHD medications and may be most effective as complementary support rather than standalone treatments. Consult with a healthcare provider for proper ADHD diagnosis and treatment.
What’s the difference between racetam alternatives and nootropic stacks?
Racetam alternatives are individual supplements that can replace synthetic racetam compounds, while nootropic stacks combine multiple ingredients in a single formula. Some pre-made stacks may include racetam alternatives along with other cognitive enhancers for comprehensive brain support. You can either buy ready-made stacks or create your own by combining individual alternatives. Building your own stack allows for more customization and dosage control, while pre-made formulas offer convenience and often synergistic ingredient combinations.
