Best Serrapeptase Supplements (2026) – Top 10 Reviewed
Serrapeptase is a powerful proteolytic enzyme originally discovered in silkworms, now widely used to support healthy inflammation response, sinus health, and tissue recovery. Its ability to break down non-living proteins makes it popular for everything from post-workout recovery to respiratory support.
The best serrapeptase supplements use delayed-release or enteric-coated capsules to protect the enzyme from stomach acid, ensuring it reaches the small intestine intact. Here are our top 10 picks for 2026.
| Product | Potency | Servings | Form | Best For |
|---|---|---|---|---|
| Zazzee Delayed Release Serrapeptase | 120,000 SPU | 120 | Delayed-Release Capsules | Best Overall |
| Double Wood Serrapeptase | 240,000 SPU | 60 | Veggie Capsules | Best High Potency |
| Doctor’s Best High Potency Serrapeptase | 120,000 SPU | 90 | Serrateric Capsules | Best for Sinus Health |
| NOW Foods Serrapeptase | 60,000 SPU | 60 | Veg Capsules | Best Budget Option |
| MaryRuth Organics Serrapeptase | 120,000 SPU | 60 | Vegan Capsules | Best Enzyme Blend |
| Source Naturals Serrapeptase | 60,000 SPU | 120 | Delayed-Release Capsules | Best Value |
| Vitamatic Serrapeptase | 240,000 SPU | 120 | DRcaps | Best for Joint Support |
| Solaray Serrapeptase | 20,000 SPU | 90 | Enteric-Coated Capsules | Best for Beginners |
| Best Naturals Serrapeptase | 40,000 SPU | 180 | Veggie Capsules | Best Long-Term Supply |
| Solaray Nattokinase Serrapeptase | 60,000 SPU + 3,000 FU | 30 | Enteric-Coated Capsules | Best Enzyme Combo |
1. Zazzee Delayed Release Serrapeptase – Best Overall
Why it stands out: Zazzee delivers a potent 120,000 SPU per capsule with delayed-release technology, ensuring maximum absorption. The 4-month supply offers exceptional value for consistent use.
This formula uses delayed-release capsules specifically designed to survive stomach acid and release in the small intestine where serrapeptase can be properly absorbed. At 120,000 SPU per single capsule, it’s potent enough for most users without requiring multiple pills. The clean formula is 100% vegetarian, non-GMO, and free from common allergens including gluten, soy, dairy, and artificial additives.
Zazzee has built a strong reputation for quality supplements with transparent third-party testing and clear labeling. Each batch is tested for potency and purity, giving you confidence that you’re getting what’s on the label. The 120-capsule bottle means you won’t be reordering every few weeks, making it convenient for those who want to maintain consistent supplementation. Users consistently report improvements in sinus comfort, joint mobility, and overall inflammatory response within the first few weeks of use.
Pros:
- High potency (120,000 SPU) in a single capsule
- 4-month supply (120 capsules) offers great value
- Delayed-release technology for optimal absorption
- Vegan, non-GMO, and allergen-free
- Third-party tested for quality assurance
Cons:
- Some users may prefer even higher potency options
Best for: Anyone seeking a reliable, high-quality serrapeptase supplement with excellent value and proven delayed-release delivery.
2. Double Wood Serrapeptase – Best High Potency
Why it stands out: At 240,000 SPU per serving, Double Wood offers one of the highest potency serrapeptase supplements available, ideal for those who need maximum enzymatic activity.
Double Wood’s formula delivers serious potency for users who need stronger support. The 240,000 SPU per 2-capsule serving makes it one of the most powerful options on the market. Manufactured and tested in the USA, this supplement is non-GMO, gluten-free, and vegetarian-safe. Research suggests higher doses of serrapeptase may help decrease mucus viscosity and support healthy immune response, making this a solid choice for those dealing with persistent congestion or inflammation.
Pros:
- Maximum 240,000 SPU potency per serving
- USA manufactured and third-party tested
- Non-GMO and vegetarian-safe
- 2-month supply per bottle
Cons:
- Requires taking 2 capsules for full dose
- Higher price point than standard potency options
Best for: Users who need maximum-strength serrapeptase support for stubborn inflammation, sinus issues, or recovery.
3. Doctor’s Best High Potency Serrapeptase – Best for Sinus Health
Why it stands out: Doctor’s Best uses their proprietary Serrateric coating technology, which provides superior protection against stomach acid compared to standard enteric coatings without using potentially harmful phthalates.
Doctor’s Best has been a trusted name in supplements for decades, and their serrapeptase formula reflects that expertise. The Serrateric coating is specifically designed to enhance intestinal absorption – it’s made from maltodextrin, tricalcium phosphate, and cellulose rather than the phthalate-based coatings found in some competing products. This matters because phthalates are actually banned in children’s toys in parts of Europe, yet they’re still found in some supplement coatings.
At 120,000 SPU per capsule, Doctor’s Best delivers clinical-strength potency in a clean, vegan-friendly formula. Users consistently report improvements in sinus comfort and respiratory function, making it particularly popular during allergy season or when dealing with chronic congestion. The product is backed by extensive quality testing and Doctor’s Best commitment to science-based formulations. Available in 90 and 270-count bottles, it scales well for both trial users and long-term supplementers.
Pros:
- Serrateric coating for superior acid protection
- Phthalate-free enteric coating technology
- Non-GMO, vegan, and gluten-free
- Trusted brand with strong scientific reputation
- Available in multiple bottle sizes
Cons:
- Slightly more expensive than generic options
Best for: Those seeking proven sinus and respiratory support from a trusted, science-backed brand with superior delivery technology.
4. NOW Foods Serrapeptase – Best Budget Option
Why it stands out: NOW Foods delivers reliable 60,000 SPU potency at an affordable price point, backed by their rigorous GMP-certified manufacturing process.
NOW Foods has been a family-owned supplement company since 1968, and their serrapeptase reflects their commitment to quality at accessible prices. The 60,000 SPU dosage is ideal for those new to serrapeptase or who prefer a moderate, well-researched dose. The formula is NPA A-rated GMP certified, meaning every aspect of manufacturing is examined for quality. While the potency is lower than premium options, studies suggest 60,000 SPU is effective for supporting immune function and respiratory health.
Pros:
- Affordable price point
- GMP-certified manufacturing
- Clean, simple formula
- Respected brand with 50+ years of experience
Cons:
- Lower potency than other options (60,000 SPU)
- NOW recommends not exceeding 30 days continuous use without physician supervision
Best for: Budget-conscious buyers and those new to serrapeptase who want to start with a moderate dose.
5. MaryRuth Organics Serrapeptase – Best Enzyme Blend
Why it stands out: MaryRuth’s unique formula combines serrapeptase with a protease blend plus enzyme-enhancing vitamins and minerals for comprehensive systemic support.
This isn’t just serrapeptase – it’s a complete enzyme support system. MaryRuth’s formula includes 120,000 SPU of enteric-coated serrapeptase plus 85,000 HUT of proteases, enhanced with B vitamins, calcium, magnesium, and manganese to help your body utilize the enzymes more efficiently. The pine-based vegan capsules are ideal for sensitive individuals, and the formula is free from all major allergens. This comprehensive approach makes it popular for those seeking broader systemic enzyme support rather than isolated serrapeptase.
Pros:
- Comprehensive enzyme blend with cofactor nutrients
- Vegan, non-GMO, and allergen-free
- Pine-based capsules for sensitive users
- Support for multiple body systems
Cons:
- More expensive than single-enzyme formulas
- Contains maltodextrin (corn-derived)
Best for: Users who want a multi-enzyme formula with added nutritional support for overall systemic health.
6. Source Naturals Serrapeptase – Best Value
Why it stands out: Source Naturals offers 120 delayed-release capsules at a competitive price, making it one of the best cost-per-serving options for long-term use.
Founded in 1982 by CEO Ira Goldberg with the vision of revolutionizing how we approach health, Source Naturals is known for their Bio-Aligned Formulas rooted in integrative health philosophy. Their serrapeptase delivers 60,000 SPU per capsule in a delayed-release vegetarian capsule designed for optimal intestinal absorption. The delayed-release technology is key – it ensures the enzyme survives the acidic environment of the stomach and reaches the small intestine where absorption occurs.
The 120-capsule bottle provides excellent value for those who plan to use serrapeptase consistently over months. At the recommended dose of 1-2 capsules twice daily, a single bottle can last 1-2 months depending on your needs. The formula is free from yeast, dairy, egg, gluten, soy, and wheat, and contains no sugar, starch, salt, preservatives, or artificial colors or flavors. Source Naturals has over 40 years in the supplement industry and maintains strict quality standards across their 600+ products.
Pros:
- 120-capsule bottle for extended use
- Delayed-release capsules for better absorption
- Free from major allergens and artificial additives
- Established brand with 40+ years of experience
- Excellent cost per serving
Cons:
- Moderate potency (60,000 SPU)
- Recommended dose is 2-4 capsules daily for full effect
Best for: Long-term users who want consistent, reliable serrapeptase at an affordable per-serving cost.
7. Vitamatic Serrapeptase – Best for Joint Support
Why it stands out: Vitamatic delivers maximum 240,000 SPU potency in DRcaps designed to survive stomach acid, at one of the lowest prices per capsule for high-potency formulas.
Vitamatic’s formula stands out for combining high potency with exceptional value. The 240,000 SPU per serving rivals premium brands at a fraction of the cost. DRcaps (delayed-release capsules) ensure the enzyme reaches the intestines intact for proper absorption. Made in a GMP-certified USA facility, this supplement targets joint mobility, sinus relief, and tissue recovery. Users frequently praise it as one of the best value high-potency serrapeptase options available.
Pros:
- High potency (240,000 SPU) at budget-friendly price
- DRcaps for stomach acid protection
- 120 capsules for extended supply
- GMP-certified USA manufacturing
Cons:
- Requires 2 capsules for full potency
- Less established brand than some competitors
Best for: Those seeking high-potency serrapeptase for joint and tissue support without premium pricing.
8. Solaray Serrapeptase – Best for Beginners
Why it stands out: Solaray’s gentle 20,000 SPU dose is perfect for those new to serrapeptase who want to assess tolerance before moving to higher potencies.
Starting with serrapeptase? Solaray’s entry-level formula is an excellent choice. At 10mg (20,000 SPU) per capsule, it allows you to start low and gradually increase your dose as needed. The enteric-coated capsules protect the enzyme from stomach acid, and Solaray’s rigorous lab testing ensures quality and potency. The formula is derived from controlled bacterial fermentation (non-animal sourced), making it suitable for vegetarians.
Pros:
- Gentle starter dose (20,000 SPU)
- Enteric-coated for acid protection
- Non-animal sourced enzyme
- 90 capsules per bottle
Cons:
- Lower potency won’t suit experienced users
- Multiple capsules needed for higher doses
Best for: First-time serrapeptase users who want to start with a conservative dose and assess their tolerance.
9. Best Naturals Serrapeptase – Best Long-Term Supply
Why it stands out: With 180 capsules per bottle, Best Naturals provides a 3-6 month supply at an affordable price, ideal for consistent daily supplementation.
Best Naturals focuses on providing quality supplements at accessible prices, and their serrapeptase delivers. The 40,000 SPU per capsule sits in a comfortable middle ground – potent enough for therapeutic benefit but gentle enough for daily use. With 180 capsules per bottle, you’re getting one of the largest supplies available, reducing the hassle and cost of frequent reorders. The formula is non-GMO, gluten-free, and made in a GMP-compliant, FDA-registered facility.
Pros:
- 180 capsules for 3-6 month supply
- Moderate potency for daily use
- Non-GMO and allergen-free
- USA manufactured in FDA-registered facility
Cons:
- No delayed-release coating specified
- Mid-range potency may not suit all needs
Best for: Users who want a reliable, affordable serrapeptase supply for consistent long-term supplementation.
10. Solaray Nattokinase Serrapeptase – Best Enzyme Combo
Why it stands out: This formula uniquely combines serrapeptase with nattokinase, delivering both proteolytic and fibrinolytic enzyme activity for comprehensive cardiovascular and sinus support in a single capsule.
Why choose one enzyme when you can have two? Solaray’s combo formula pairs 60,000 SPU of serrapeptase with 3,000 FU (fibrinolytic units) of nattokinase extracted from fermented soybeans. These enzymes work through different mechanisms – nattokinase is a fibrinolytic enzyme that breaks down fibrin (a protein involved in blood clotting) to support healthy blood flow and circulation, while serrapeptase is a proteolytic enzyme that targets sinus health, mucus, and inflammatory proteins.
The enteric-coated capsules ensure both enzymes survive stomach acid for intestinal absorption. Solaray manufactures in GMP-certified facilities with state-of-the-art lab testing in Utah, and they back this product with a 60-day money-back guarantee. As part of their sustainability efforts, Solaray bottles are made from post-consumer recycled resin, and they’ve installed solar panels at their facility. This dual-action formula has developed a strong following among those seeking cardiovascular and respiratory support, with many users reporting improvements in circulation and sinus comfort.
Pros:
- Dual enzyme action (nattokinase + serrapeptase)
- Cardiovascular and sinus support in one formula
- Enteric-coated for optimal absorption
- Lab-verified with 60-day money-back guarantee
- Environmentally conscious manufacturing
Cons:
- Contains soy (from nattokinase source)
- Only 30 capsules per bottle
- Not suitable for those on blood thinners without physician approval
Best for: Users seeking combined cardiovascular and respiratory enzyme support in a single, convenient supplement.
What is Serrapeptase and Who Should Take It?
Serrapeptase (also called serratiopeptidase) is a proteolytic enzyme originally discovered in the digestive system of silkworms. It’s produced by the bacterium Serratia E-15 and helps silkworms dissolve their cocoons. Today, serrapeptase is produced through controlled bacterial fermentation and used as a dietary supplement throughout Europe, Japan, and increasingly in North America.
The enzyme works by breaking down non-living proteins, including fibrin, mucus, and inflammatory proteins that can accumulate in tissues. Unlike digestive enzymes that work only in the gut, serrapeptase is absorbed into the bloodstream and travels throughout the body to target unwanted protein buildup wherever it occurs. This systemic action is what makes it popular among those dealing with sinus congestion, post-surgical recovery, sports injuries, joint discomfort, and general inflammation.
People most likely to benefit from serrapeptase include those experiencing chronic sinus issues or respiratory congestion, individuals recovering from surgery or injuries, athletes dealing with exercise-induced inflammation or muscle soreness, anyone with joint stiffness or mobility concerns, and those looking to support healthy tissue recovery. The enzyme has been used in clinical settings in parts of Europe and Asia for decades, particularly following surgical procedures to support the healing process.
How to Choose the Right Serrapeptase Supplement
Key Factors to Consider
Potency (SPU): Serrapeptase potency is measured in Serrapeptase Units (SPU), which indicates the actual enzymatic activity of the supplement. Doses range from 20,000 SPU for beginners to 240,000 SPU for high-potency formulas. Most clinical studies use between 30,000-60,000 SPU daily, though higher doses are commonly used for more stubborn issues. If you’re new to serrapeptase, start with a lower potency (40,000-60,000 SPU) and increase gradually as you assess your tolerance and results.
Delayed-Release Technology: This is perhaps the most critical factor. Serrapeptase is easily destroyed by stomach acid – without protection, most of the enzyme may be deactivated before it can be absorbed. Look for enteric-coated, delayed-release, or DRcaps formulations that protect the enzyme until it reaches the small intestine where it can be absorbed intact. Supplements without acid protection may deliver significantly less active enzyme than what’s listed on the label.
Source and Manufacturing: Quality serrapeptase should come from controlled bacterial fermentation (not directly from silkworms). Look for supplements from GMP-certified facilities, ideally with third-party verification of potency and purity. USA-manufactured products often have stricter quality controls, though reputable international manufacturers can also produce excellent products.
Additional Ingredients: Some formulas add complementary enzymes like proteases or combine serrapeptase with nattokinase for broader enzyme support. Others include cofactor vitamins and minerals to enhance enzyme utilization. Decide whether you want a pure serrapeptase product or a more comprehensive enzyme blend.
Forms Compared
Capsules are the standard delivery method for serrapeptase, with delayed-release or enteric-coated versions offering the best absorption. Standard vegetarian capsules without special coating are less effective because they don’t protect the enzyme from stomach acid. Some products use proprietary coatings like Doctor’s Best Serrateric technology, which avoids potentially harmful phthalates found in some traditional enteric coatings. DRcaps (delayed-release capsules) are another excellent option that use a special polymer to slow dissolution.
Powders are available but less common since they lack stomach acid protection – they’d need to be consumed in a way that bypasses stomach acid, which is impractical for most users. Tablets are occasionally available but capsules remain the gold standard.
What to Avoid
Skip supplements without delayed-release technology – standard capsules expose serrapeptase to stomach acid, potentially destroying the enzyme before absorption. This is essentially throwing money away. Avoid products with excessive fillers, artificial colors, or unnecessary additives. Check for allergen warnings if you have sensitivities, as some formulas contain soy (particularly combination products with nattokinase), dairy derivatives, or gluten-containing ingredients.
Be wary of extremely low-priced products that seem too good to be true – serrapeptase production requires careful fermentation processes, and quality raw materials aren’t cheap. Also avoid products that only list mg instead of SPU, as milligrams alone don’t tell you the actual enzymatic activity.
Side Effects and Precautions
Serrapeptase is generally well-tolerated when taken as directed on an empty stomach. The most commonly reported side effects include mild digestive discomfort, nausea, bloating, and occasionally skin reactions in sensitive individuals. These effects are typically mild and temporary, often resolving within the first few days of use as the body adjusts. Starting with a lower dose and gradually increasing can help minimize digestive upset.
Due to its ability to break down fibrin and affect blood clotting, serrapeptase should not be taken alongside blood-thinning medications like warfarin (Coumadin), heparin, aspirin, or clopidogrel (Plavix) without explicit physician approval. Supplements that also affect blood clotting – including fish oil, garlic, ginkgo biloba, vitamin E, and turmeric – can compound this effect when combined with serrapeptase, potentially increasing bleeding risk.
Pregnant or nursing women should consult their healthcare provider before use, as there isn’t sufficient research on serrapeptase safety during pregnancy. If you have a scheduled surgery, discontinue use at least two weeks prior to reduce any potential bleeding complications. Those with gastric ulcers, bleeding disorders, or liver or kidney disease should also consult a healthcare professional before starting serrapeptase. Always take serrapeptase on an empty stomach – taking it with food causes it to work on digesting your meal rather than providing systemic benefits.
FAQs
How should I take serrapeptase for best results?
Take serrapeptase on an empty stomach with at least 8 ounces of water, either 30-60 minutes before eating or 2 hours after a meal. This prevents the enzyme from digesting food proteins instead of working systemically throughout your body.
How long does it take for serrapeptase to work?
Most users report noticing effects within 2-4 weeks of consistent daily use. However, results vary depending on the issue being addressed and individual factors. For chronic conditions, some users report more significant improvements after 8-12 weeks.
Can I take serrapeptase with nattokinase?
Yes, many people stack serrapeptase with nattokinase for combined benefits. Serrapeptase is a proteolytic enzyme (breaks down proteins) while nattokinase is a fibrinolytic enzyme (breaks down fibrin). Some supplements combine both, like the Solaray Nattokinase Serrapeptase formula on our list.
What’s the difference between SPU and mg on serrapeptase labels?
SPU (Serrapeptase Units) measures the actual enzymatic activity, while mg measures the weight. Activity units are more meaningful for enzymes. Generally, 10mg equals approximately 20,000 SPU, but this can vary by manufacturer. Always compare products by SPU rather than mg.
Is serrapeptase safe for long-term use?
Serrapeptase has been used in Europe and Japan for decades. However, some manufacturers like NOW Foods recommend physician supervision for continuous use beyond 30 days. If you plan to use serrapeptase long-term, consult with your healthcare provider and consider periodic breaks.
Can serrapeptase help with scar tissue?
Serrapeptase’s ability to break down non-living protein makes it popular for supporting healthy scar tissue remodeling. While anecdotal reports are positive, more clinical research is needed. Some users take serrapeptase specifically to support recovery from surgeries or injuries that may cause scarring.
Final Verdict
For most users, Zazzee Delayed Release Serrapeptase offers the best combination of potency, quality, and value with its 120,000 SPU formula and 4-month supply. The delayed-release technology ensures you’re actually absorbing what you’re paying for, and the clean, allergen-free formula works for nearly everyone. It’s our top overall recommendation.
If you need maximum potency for stubborn issues, Double Wood Serrapeptase at 240,000 SPU delivers serious enzymatic activity. It’s ideal for those who have tried standard doses and need something stronger, or for users dealing with persistent inflammation or congestion.
For those on a budget, NOW Foods Serrapeptase provides reliable quality from a trusted brand with over 50 years of experience at an accessible price point. The 60,000 SPU dose aligns with clinical research and works well for general maintenance.
If you’re new to serrapeptase, start with Solaray’s gentle 20,000 SPU formula to assess your tolerance before moving to higher doses – some people experience initial adjustment symptoms, and starting low helps you find your optimal dose. And for comprehensive enzyme support that goes beyond serrapeptase alone, MaryRuth Organics offers a unique blend of enzymes plus supporting nutrients that many users find more effective than isolated serrapeptase.
Whatever you choose, remember that delayed-release or enteric-coated formulas are essential – without stomach acid protection, you’re likely losing most of the enzyme before it can work. Consistency matters too; most users report the best results after 2-4 weeks of daily use.
