Best Supplements for Adrenal Fatigue (2026) – Top 10 Reviewed
Adrenal fatigue occurs when your adrenal glands become overworked from chronic stress, leading to persistent exhaustion, difficulty waking up, afternoon crashes, and poor stress tolerance. While controversial in conventional medicine, many people find that supporting adrenal health helps restore their energy and resilience. This guide reviews the best supplements specifically formulated to nourish your adrenal glands and help you reclaim your vitality.
Our Top Picks at a Glance
- Best Overall: Nature’s Nutrition Adrenal Support – comprehensive gland support
- Best Value: Adrenal System Support – 2-month supply with adaptogens
- Best Premium: Thorne Adrenal Cortex – glandular support formula
Quick Comparison
| Product | Key Ingredients | Form | Servings | Best For |
|---|---|---|---|---|
| Nature’s Nutrition Adrenal Support | Ashwagandha, Rhodiola, B Vitamins | Capsules | 120 | Overall adrenal health |
| Adrenal System Support | Ashwagandha, L-Tyrosine, Ginseng | Capsules | 60 | Cortisol balance |
| Thorne Adrenal Cortex | Bovine Adrenal Cortex 50mg | Capsules | 60 | Glandular support |
| aSquared Rhodiola Rosea | Rhodiola 1000mg | Vegan Capsules | 180 | Stress adaptation |
| WellPath Zen Stress Relief | Ashwagandha, Rhodiola, 5-HTP | Capsules | 60 | Energy & mood |
| Cortisol Supplements 10-in-1 | Ashwagandha, Magnesium, L-Theanine | Capsules | 60 | Cortisol regulation |
| Double Wood Adrenal Support | 10 Adaptogen Liquid Blend | Liquid Drops | 30 | Fast absorption |
1. Nature’s Nutrition Adrenal Support – Best Overall
- ADVANCED NATURAL ENERGY, ADRENAL SUPPORT: Nature's Nutrition adrenal support features like ashwagandha & rhodiola to support natural energy, supports adrenal fatigue & daily health; a powerful supplement & natural energy for men and women
- EFFECTIVE ADRENAL SUPPORT SUPPLEMENT: Premium adrenal ashwagandha & herbal extracts; making it an ideal adrenal health supplement for focus & calm support
- BEST ADRENAL SUPPORT SUPPLEMENTS: Our advanced adrenal ashwagandha supplement for women and men calm support formula; it works as a trusted supplement & daily capsule for anyone needing energy support
- TRUSTED ADRENAL, IMMUNE SUPPORT FORMULA: Natures Nutrition adrenal health supplements are non GMO, gluten free & bottled in the USA; herbal supplement supports adrenal fatigue, for immune support, making it one of the best adrenal ashwagandha capsules available
- ADRENAL SUPPORT SUPPLEMENTS: extra strength best adrenal cortex complex ashwagandha with vitamins 60 herb capsules natural supplement herbs vegan extract for women men active night formula adren caps adrenall glandular cocktail vitamin c daily energy health support to gland fatigue rhodiola calm natures nutrition dietary supplements all standard nutritional process adrenochrome desiccated
Nature’s Nutrition delivers comprehensive adrenal support through proven adaptogens combined with essential vitamins for gland health.
This formula features ashwagandha and rhodiola to help your adrenals adapt to stress more effectively, while B vitamins and vitamin C provide the nutrients your adrenal glands need to produce hormones and maintain function. The 120-capsule bottle offers two months of support for restoring adrenal health and natural energy production.
What We Like
- Combines adaptogenic herbs with adrenal-supporting vitamins
- B vitamins directly support stress hormone production
- Vitamin C is essential for adrenal cortisol synthesis
- Non-GMO, gluten-free formula manufactured in USA
What Could Be Better
- B vitamins may cause bright yellow urine (harmless)
- Best taken with food to prevent potential nausea
Bottom Line: A well-balanced formula that addresses both the stressors taxing your adrenals and the nutrients they need to recover.
2. Adrenal System Support & Cortisol Manager – Best Value
- Keep Your Stress In Check: Too much cortisol flowing through your body can lead to decreased cognitive performance, imbalances, and more. Too little can bring brain fog and unease. Strike the right balance by maintaining already healthy cortisol levels with our Adrenal System Support supplement. We recommend one capsule daily, also pairs well with Thyroid Support.
- Maintain Cortisol Balance: From basics like Vitamins C and B6 to Eleutherococcus Senticosus, we’ve carefully selected each ingredient in this adrenal system support supplement for its ability to help regulate occasional stress and maintain normal adrenal system function.
- Dial Down: Occasional stress is part of life, but it need not dampen the mind or body. That’s why we include the best ingredients such as L-Tyrosine, Ginseng, Rhodiola Root, Suma Root, Holy Basil Leaf, and more in our Adrenal System Support supplement. These work in concert to promote calm and help your body adapt to varying levels of stress.
- Manufactured To Rigorous Standards: We elect to manufacture at a GMP-certified facility, right here in the USA, using globally sourced ingredients. This means you can be confident that each capsule of our cortisol supplement will contain only natural, high-quality manger ingredients with no fillers or junk substitutes.
- Order Today: Experience the difference that maintaining well-regulated cortisol levels can make to your day. Click add to cart today!
This two-month supply combines powerful adaptogens with amino acids to support healthy adrenal function and balanced cortisol levels.
The formula features ashwagandha and rhodiola for stress adaptation, L-tyrosine to support neurotransmitter production, plus suma root, holy basil, and ginseng for comprehensive adrenal support. Vitamins C and B6 provide additional nutritional support for adrenal hormone synthesis and energy metabolism.
What We Like
- Multiple adaptogens provide broad-spectrum adrenal support
- L-tyrosine supports both adrenal function and mental energy
- Includes key vitamins C and B6 for hormone production
- Vegetarian and vegan-friendly capsules
What Could Be Better
- L-tyrosine may interact with thyroid medications
- Best taken in morning to avoid potential sleep disruption
Bottom Line: Excellent value for a comprehensive adrenal support formula with multiple proven ingredients.
3. Thorne Adrenal Cortex – Best Premium
- Support For A High-Stress World: Lifestyle habits that deprive us of adequate rest and exercise, and poor dietary habits can, over time, take their toll on the adrenal glands
- Adrenal support: Formulated with a unique extract to nourish the adrenal glands, which help regulate metabolism and the body’s stress response*
- Promote energetic feelings: Helps maintain immune function and promotes an energetic feeling*
- Stabilize stress hormone: Helps stabilize the stress hormone, cortisol, which naturally peaks in the morning and declines during the day – too much stimulus (stress) can cause cortisol to get out of balance
- Trusted: Thorne is chosen by champions and trusted by 100+ professional sports teams, a proud partner of U.S. National Teams, and the #1 recommended clinical brand by health-care practitioners (2023 Health-Care Practitioner Seller Survey)
Thorne’s glandular formula provides direct adrenal cortex tissue to support your own adrenal gland function.
This supplement contains 50mg of bovine adrenal cortex per capsule, offering targeted support for adrenal health through glandular therapy. The approach is based on the principle that consuming adrenal tissue provides the raw materials and cofactors your own adrenal glands need to function optimally.
What We Like
- Glandular approach provides direct adrenal tissue support
- Thorne’s reputation for quality and purity testing
- Can be taken 1-3 times daily based on needs
- Gluten-free and dairy-free formulation
What Could Be Better
- Contains bovine ingredients unsuitable for vegetarians/vegans
- Higher price point reflects premium quality
Bottom Line: A premium glandular option for those seeking direct adrenal cortex support from a trusted brand.
4. aSquared Rhodiola Rosea Supplement 1000mg – Best for Stress Adaptation
- MAXIMUM STRENGTH RHODIOLA ROSEA: Our potent Rhodiola Rosea formula contains 500mg per veggie capsule (1000mg per serving), and is made in the USA in a GMP compliant facility. Rhodiola Rosea is known as an Adaptogen, helping the body adapt to stress. The Rhodiola plant is native to the arctic regions of Asia, Europe and even Siberia. Don't settle for 60, 90 or 120 capsules. We offer 180 vegan capsules per bottle. *
- HELPS BOOST ENERGY, MOOD & PERFORMANCE: Rhodiola Rosea helps boost energy levels, supports normal and elevated mood, and may even increase physical and athletic performance. Additionally, Rhodiola Rosea promotes healthy immune system and thyroid function. Similar to Panax Ginseng and Ashwagandha, Rhodiola is an adaptogen and is often used to help the mind and body adapt to stress. *
- HELPS BOOST MEMORY & BRAIN FUNCTION: Rhodiola Rosea promotes healthy brain function, supports increased memory. Rhodiola Rosea may improve the absorbency of the blood-brain barrier supporting normal transport of the neurotransmitters serotonin and dopamine that are essential for promoting healthy mood. Additionally, Rhodiola has antioxidant properties. *
- BEST VALUE AVAILABLE ON AMAZON: Our high potency Rhodiola Rosea complex comes with 180 veggie capsules, each containing 500 mg of Rhodiola – not to be confused with the forms of Rhodiola such as Drops, Oil, Liquid, Drink, Cream, Caps, Chewable, and Tea – and contains a high dosage of Rosavin and Salidrosid.. Rhodiola Rosea is also called Arctic Root, Goldenroot, Rose Root Extract, Rosenroot, Sedum Rhodiola, Roseroot, Siberian Golden Root and more. *
- PROVEN TRACK RECORD: aSquared Nutrition takes pride in quality and reliability. You’ll love our ever-expanding product line from CoQ10 400mg (Coenzyme Q10) to Vitamin B-12 (Methyl B12). Other products include Panax Ginseng, Milk Thistle 1000 MG, DHEA 100mg, Resveratrol 1000mg, Turmeric Curcumin, Natural Ceylon Cinnamon (100% All Natural), Green Coffee Bean Extract, Garcinia Cambogia, Berberine, and Forskolin 500mg. *
Rhodiola excels at helping your adrenal glands adapt to stress without becoming depleted and exhausted.
This high-potency supplement delivers 1000mg of rhodiola root extract per serving in vegan capsules, with 180 servings per bottle. Research shows rhodiola supports healthy cortisol patterns, reduces fatigue, and helps maintain adrenal function during periods of high stress.
What We Like
- Maximum strength rhodiola for optimal adaptogenic effects
- Strong research backing for adrenal stress protection
- 180 vegan capsules offer excellent long-term value
- Single ingredient ideal for targeted supplementation
What Could Be Better
- Works best when combined with adrenal-supporting nutrients
- May take several weeks to notice full benefits
Bottom Line: One of the best single-ingredient options for protecting your adrenals from stress damage.
5. WellPath Zen Stress Relief Supplement – Best for Energy & Mood
- [Stress Relief Formula] Do you get overwhelmed by daily stressors? We know the feeling! Which is why we created Zen. It's expertly curated with herbs, vitamins, and adaptogens to support your daily stressors and help you live in a zen state of mind!
- [Stay Focused and Calm] You deserve to live a happy, healthy life. That's why we combine superfoods like Passionflower & Niacinamide powder with Riboflavin and magnesium in our products so you can be more positive throughout your day!
- [Vitamins for Men and Women] Zen's vitamin supplement is a vegan daily multivitamin for women and men who want to help improve their mood. We use naturally sourced herbal ingredients to help cultivate a positive sense of well-being.
- [Premium Herbal Ingredients] WellPath Zen's calming vitamin features Ashwagandha, an Ayurvedic herb known to assist with balancing occasional stress; Rhodiola Rosea, L-Theanine, Hawthorn Leaf, Lemon Balm & more! Designed for your daily stress support
- [Featuring Ashwagandha + Rhodiola Rosea] Ashwagandha & Rhodiola Rosea are adaptogenic herbs known for their ability to help the body adapt to stress & improve energy levels.
WellPath Zen addresses adrenal fatigue’s impact on both physical energy and emotional wellbeing.
The formula combines ashwagandha and rhodiola to support adrenal stress response with 5-HTP for mood support – addressing the depression and low mood that often accompany adrenal exhaustion. This comprehensive approach helps restore the energy and emotional stability that adrenal fatigue disrupts.
What We Like
- Addresses both energy and mood symptoms of adrenal fatigue
- Dual adaptogen formula for comprehensive stress support
- 5-HTP supports serotonin production for better mood
- Non-habit forming ingredients safe for long-term use
What Could Be Better
- 5-HTP may cause vivid dreams in some users
- Full benefits develop gradually over several weeks
Bottom Line: Excellent choice when adrenal fatigue has affected both your energy levels and emotional state.
6. Cortisol Supplements for Women Men 10-in-1 – Best for Cortisol Regulation
- Targeted Cortisol Management - Clinically formulated to help manage cortisol levels in the body, supporting a balanced cortisol response during pressure; Our cortisol detox adaptogenic blend (ashwagandha, chamomile, phosphatidylserine) works synergistically to regulate cortisol production—These cortisol supplements for women/men ideal for busy professionals, parents, or anyone seeking adrenal support without fillers or additives
- Pressure Management & Relaxation - Are you still struggling with office pressure? Our cortisol reducer supplements blend tension-fighting ingredients like magnesium glycinate (122mg) and L-theanine (50mg) to promote relaxation while maintaining mental clarity; The addition of vitamin C (90mg) and D3 (20mcg) supports overall wellness, helping you cope with pressure naturally
- Science-Backed Formulation - Every capsule delivers precise dosages: 250mg ashwagandha extract (20:1), 50mg chamomile (10:1), and 24mg phosphatidylserine for optimal effectiveness; Unlike generic lower cortisol for women, these cortisol supplement use no synthetic fillers—just a clean, vegan-friendly formula trusted by health-conscious users
- Dual-Action Cortisol Balance for All Lifestyles - Whether you’re a fitness enthusiast, a night-shift worker, or juggling daily demands, our cortisol reducer adapts to your needs; St. John’s wort (20mg) and astragalus (20mg) support mood stability*, while black pepper extract (10:1) ensures maximum nutrient absorption; Take 2 capsules daily—morning and evening—for sustained cortisol support
- 60-Day Supply - We stand behind our cortisol supplement for men and women with rigorous quality testing; Our formula is non-GMO, allergen-free, and manufactured in a cGMP facility; Join thousands who’ve transformed their tension management—try CortiCare risk-free and experience why we’re ranked among the best supplements to lower cortisol!
Adrenal fatigue often involves cortisol dysregulation, and this 10-ingredient formula helps restore healthy hormone patterns.
The supplement combines ashwagandha for stress adaptation with magnesium glycinate and L-theanine to support healthy cortisol rhythms throughout the day. By helping normalize cortisol production – often both too high and too low at different times in adrenal fatigue – it addresses a key underlying mechanism.
What We Like
- Specifically targets cortisol dysregulation in adrenal fatigue
- Magnesium glycinate is highly absorbable and adrenal-supportive
- L-theanine promotes calm without affecting energy
- Comprehensive 10-ingredient formula at competitive price
What Could Be Better
- Multiple ingredients increase potential for interactions
- Newer brand with less extensive user feedback
Bottom Line: Strong choice when abnormal cortisol patterns are driving your adrenal fatigue symptoms.
7. Double Wood Adrenal Support Liquid Drops – Best for Fast Absorption
- CORTISOL SUPPLEMENT: Double Wood's Adrenal Support Drops contain over 10 different Adaptogens for Adrenal health to help you manage cortisol and relieve stress
- 10 DIFFERENT ADAPTOGENS: Double Wood's Adaptogen Complex for Adrenal Fatigue contains a proprietary blend of the following 10 Adaptogens - Astragalus Root, Wood Betony Herb, Ginkgo Lead, Eleuthera Root, Gotu Kola, Rhodiola, Licorice Root, Lavender Flower, Spearmint Leaf, and Passionflower Leaf
- STRESS RELIEF SUPPLEMENT: Adaptogens are herbal supplements that can help your body respond to stress and fatigue. They can help with overall wellbeing and energy levels by helping you manage both physical and mental stressors
- ROOTED IN QUALITY: Manufactured and Tested in the USA from Globally Sourced Ingredients. Double Wood's Liposomal Glutathione is manufactured and tested for microbes and heavy metals right here in the USA from Globally Sourced Ingredients. Plus, they are Vegetarian safe, Non-GMO and gluten-free
- WE BOTTLE WELLNESS: At Double Wood we provide pure, potent supplements that deliver exceptional value, all backed by careful sourcing and rigorous third-party testing
This liquid formula combines 10 organic adaptogens in drops for faster absorption than capsules.
Double Wood’s blend includes astragalus, rhodiola, eleuthero, ginkgo, gotu kola, licorice root, lavender, and passionflower – providing comprehensive adaptogenic support for stressed adrenal glands. The liquid format allows for flexible dosing and may absorb more quickly than pills.
What We Like
- 10 different adaptogens provide broad-spectrum support
- Liquid drops may absorb faster than capsules
- Flexible dosing allows gradual increase as needed
- Organic, vegetarian-safe ingredients
What Could Be Better
- Liquid format less convenient for travel than capsules
- Some users dislike herbal taste despite spearmint
Bottom Line: Unique liquid format offers fast-absorbing adaptogenic support for exhausted adrenal glands.
How to Choose the Best Supplement for Adrenal Fatigue
Begin by identifying your primary adrenal fatigue symptoms and their patterns. If you struggle most with morning fatigue and difficulty waking, look for supplements containing vitamin C and B vitamins to support cortisol production. If afternoon crashes are your main issue, adaptogens like rhodiola that help stabilize energy throughout the day may serve you better. For sleep problems despite exhaustion, consider formulas with calming adaptogens like ashwagandha.
Consider whether you prefer herbal adaptogens or glandular support. Adaptogenic herbs like ashwagandha, rhodiola, and holy basil work indirectly by helping your body adapt to stress and regulate hormone production. Glandular supplements contain actual adrenal tissue from animals, working on the principle of “like supports like.” Some people respond better to one approach over the other.
Pay attention to timing and lifestyle factors. If your adrenal fatigue stems from chronic work stress, you’ll need different support than someone recovering from illness or trauma. Long-standing adrenal exhaustion typically requires longer supplementation periods – 6-12 months isn’t uncommon. Choose products with good value for extended use.
Evaluate quality indicators carefully since you’ll be taking these supplements long-term. Look for products manufactured in GMP-certified facilities, third-party tested for purity, and containing standardized herbal extracts at clinically studied dosages. Avoid proprietary blends that don’t disclose individual ingredient amounts.
Think about how supplements fit with other health interventions. Adrenal fatigue recovery requires more than just pills – adequate sleep, stress management, blood sugar stability, and proper nutrition are equally important. Choose supplements that complement rather than replace these fundamental lifestyle factors.
Benefits of Supplements for Adrenal Fatigue
Adrenal support supplements work through multiple mechanisms to restore healthy gland function and stress resilience. Adaptogenic herbs help regulate your hypothalamic-pituitary-adrenal (HPA) axis, which controls cortisol production. By supporting healthy cortisol rhythms – higher in morning, lower at night – these supplements can help restore the natural energy patterns that adrenal fatigue disrupts.
Many adrenal supplements provide nutrients essential for hormone synthesis. Your adrenal glands require vitamin C in high concentrations to produce cortisol and other stress hormones. B vitamins, particularly B5 (pantothenic acid), are crucial for adrenal function and energy metabolism. Magnesium supports both the nervous system and adrenal hormone production. Supplementing these nutrients helps ensure your adrenals have the raw materials they need to function.
Quality adrenal supplements also help protect your adrenal glands from further stress damage. Chronic stress can cause oxidative damage and inflammation in adrenal tissue. Antioxidant compounds in adaptogenic herbs like rhodiola and ashwagandha help neutralize harmful free radicals and reduce inflammation, supporting adrenal healing and recovery.
Beyond direct adrenal effects, these supplements often improve related symptoms that perpetuate the fatigue cycle. Better sleep quality allows more complete overnight adrenal recovery. Improved blood sugar stability prevents the stress hormone spikes that exhaust your adrenals. Enhanced mood and stress tolerance reduce the daily burden on your adrenal glands, allowing them to heal.
Frequently Asked Questions
Is adrenal fatigue a real medical condition?
Adrenal fatigue is controversial in conventional medicine – most endocrinologists don’t recognize it as a distinct diagnosis. However, many integrative and functional medicine practitioners use the term to describe a syndrome of chronic stress-related symptoms including fatigue, difficulty waking, salt cravings, and poor stress tolerance. Whether you call it “adrenal fatigue” or “HPA axis dysfunction,” the symptoms are real and often respond to stress management and targeted supplementation.
How long does it take to recover from adrenal fatigue?
Recovery timelines vary dramatically based on severity and how long you’ve been experiencing symptoms. Mild adrenal fatigue might improve within 6-12 weeks with proper support, while severe cases can take 12-24 months or longer. Recovery isn’t linear – you’ll likely experience ups and downs. Consistent supplementation combined with lifestyle changes yields better results than supplements alone.
Can I take adrenal supplements with thyroid medication?
Some adrenal supplements may interact with thyroid medications, particularly those containing iodine, L-tyrosine, or ashwagandha (which can influence thyroid function). Always consult your healthcare provider before combining adrenal supplements with thyroid medication, as timing and dosage adjustments may be necessary. Your doctor should monitor your thyroid levels if you take both.
Should I take adrenal supplements in the morning or evening?
Most adrenal supplements work best when taken in the morning or early afternoon to support your natural cortisol rhythm, which should be highest in the morning and decline through the day. Energizing adaptogens like rhodiola are particularly important to take early. However, if your formula contains calming ingredients like magnesium or holy basil, evening dosing might be appropriate. Check your specific product’s recommendations.
Will adrenal supplements help me lose weight?
Adrenal dysfunction can contribute to weight gain, particularly around the midsection, through elevated cortisol and metabolic disruption. While adrenal supplements aren’t weight loss products per se, restoring healthy adrenal function may help normalize metabolism and reduce stress-related weight gain. However, they work best as part of a comprehensive approach including proper nutrition and stress management.
Can adrenal fatigue supplements help with anxiety?
Yes, many adrenal support supplements contain adaptogens and nutrients that help reduce anxiety symptoms. Dysregulated cortisol contributes to anxiety, and ingredients like ashwagandha, L-theanine, and magnesium have anxiolytic (anxiety-reducing) properties. However, if you have a diagnosed anxiety disorder or take anxiety medications, consult your healthcare provider before adding adrenal supplements.
Are there any foods that support adrenal health?
Yes, several foods support adrenal function: vitamin C-rich foods (citrus, bell peppers, berries), B vitamin sources (whole grains, eggs, leafy greens), magnesium-rich foods (nuts, seeds, dark chocolate), healthy fats (avocados, olive oil, fatty fish), and quality proteins. Maintaining stable blood sugar through regular meals with protein and healthy fats also protects your adrenals from unnecessary stress.
What’s the difference between adrenal fatigue and chronic fatigue syndrome?
While both conditions involve persistent fatigue, they differ in origin and characteristics. Adrenal fatigue specifically relates to stress-induced HPA axis dysfunction with characteristic cortisol pattern changes. Chronic Fatigue Syndrome (CFS/ME) is a recognized medical condition involving severe, debilitating fatigue that doesn’t improve with rest, often following viral infections. CFS typically involves additional symptoms like cognitive impairment and post-exertional malaise. If your fatigue is severe or unexplained, seek medical evaluation.
