Best Supplements for AFib (2026) – Top 10 Reviewed
Living with atrial fibrillation (AFib) requires careful management, and while supplements can’t replace medical treatment, certain nutrients may help support normal heart rhythm and overall cardiovascular health. This guide explores the supplements that research suggests may be beneficial as part of a comprehensive approach to managing AFib, always in consultation with your healthcare provider.
Our Top Picks at a Glance
- Best Overall: ZEBORA CoQ10 400mg – comprehensive cardiac energy support
- Best Value: Quick Absorption CoQ10 200mg – potent antioxidant at great price
- Best Premium: Luma Nutrition Omega 3 2500mg – extra strength fish oil
Quick Comparison
| Product | Key Ingredients | Form | Servings | Best For |
|---|---|---|---|---|
| ZEBORA CoQ10 400mg | CoQ10, PQQ, Omega-3, BioPerine | Softgels | 120 | Complete support |
| Quick Absorption CoQ10 200mg | CoQ10 200mg | Capsules | 120 | Daily use |
| Luma Omega 3 2500mg | EPA 1400mg, DHA 1000mg | Softgels | 120 | High potency |
| ZEBORA CoQ10 300mg | CoQ10, PQQ, BioPerine | Softgels | 120 | Mid-range dose |
| NATURE TARGET CoQ10 300mg | CoQ10, PQQ, Olive Oil | Softgels | 60 | Enhanced absorption |
| NATURELO D3 K2 5000 IU | D3 5000 IU, K2 MK7 100mcg | Capsules | 90 | Vegan vitamin D |
| CoQ10 600mg Softgels | CoQ10, PQQ, Omega-3 | Softgels | 60 | Maximum strength |
| Quick Absorption CoQ10 400mg | CoQ10 400mg | Capsules | 60 | High-dose option |
1. ZEBORA CoQ10 400mg with PQQ – Best Overall
- ENHANCED COQ10 WITH PQQ: Our CoQ10 400mg, with a 120-day supply, boosts natural CoQ10 levels for heart health. Combined with PQQ, it enhances mitochondrial energy production, vital for efficient energy and optimal heart function
- HIGH BIOAVAILABILITY: ZEBORA CoQ10 is enhanced with Black Pepper Extract and Sunflower Lecithin for superior absorption and bioavailability. Black Pepper offers antioxidant benefits, while sunflower lecithin supports skin and liver health
- OPTIMAL COMBINED OMEGA-3: Every Coq10 softgel contains 60 mg of omega-3s, which are imperative to promoting heart health. Omega-3s can improve sleep quality, support the eyes, skin, and brain health. Better absorption, better taste, and no fishy burps
- BENEFITS FOR STATIN USERS: CoQ10 is crucial for producing 95% of your body's energy, but levels decline with statin use. Supplementing with CoQ10 during statin therapy helps replenish lost levels, supporting energy production and overall organ function
- NATURAL AND PURE: All our products are third-party tested and are manufactured in a cGMP-certified facility. No Artificial Flavors or Sweeteners, No Sugar, No Starch, No Gluten, No Soy, No Wheat, and Sodium-free
This comprehensive formula delivers the CoQ10, PQQ, and omega-3s your heart needs to maintain healthy energy production and cellular function.
AFib often depletes your heart’s energy reserves, and CoQ10 is critical for maintaining the cellular energy your heart muscle needs. At 400mg, this dose provides therapeutic levels shown in studies to support cardiovascular health. The addition of PQQ supports mitochondrial function, while BioPerine enhances absorption of these fat-soluble nutrients.
What We Like
- High 400mg CoQ10 dose provides clinical-level support
- PQQ enhances mitochondrial energy production in heart cells
- 120 servings offer four months of consistent use
What Could Be Better
- Large softgel size may be difficult for some to swallow
- Higher price point reflects premium ingredient quality
Bottom Line: A comprehensive formula that addresses multiple cardiovascular pathways important for AFib management.
2. Quick Absorption CoQ10 200mg – Best Value
- Precision Dosage: Our CoQ10 supplement is made with high absorption and stable CoQ 10 200mg per serving from ubiquinone so you get more out of every capsule
- Why Ubiquinone: Get the most out of each dose with our CoQ10 nutritional supplements made with a more stable form in our easy to swallow capsules for even better nutrient absorption
- The Clear Difference: At Clear Formulas we believe transparency and trust are essential which is why our product is made in an FDA inspected American facility according to strict regulatory guidelines
- Made for All in Mind: We stand by our name and our formula is made without many common allergens and additives including corn, dairy, gluten, salt, or artificial preservatives and flavors
- The Choice is Clear: We believe health doesn't have to be hard - We make it simple with carefully designed supplements to support your needs whatever your age and lifestyle we've got you covered
This potent antioxidant formula provides clinical-strength CoQ10 at a price point that makes consistent supplementation affordable.
With 200mg of CoQ10 per capsule, you’re getting a dose that’s been studied for cardiovascular support. The quick absorption formula is designed to maximize bioavailability, ensuring your body can actually use what you’re taking.
What We Like
- 200mg dose balances therapeutic benefits with value
- Enhanced absorption technology improves bioavailability
- 120-count bottle provides four months of daily support
What Could Be Better
- Doesn’t include synergistic ingredients like PQQ
- May need higher doses for some individuals with AFib
Bottom Line: An excellent choice for budget-conscious individuals seeking quality CoQ10 supplementation for heart health.
3. Luma Nutrition Omega 3 2500mg – Best Premium
- Best Omega 3 Supplement: Luma Nutrition's fish oil omega 3 supplements are premium quality with an extra strength dosage. Omega 3 fish oil with 2000mg of high quality EPA & DHA Omega 3 fatty acids, all in a softgel capsule to enhance absorption for maximum benefits.
- High EPA Fish Oil: Our product is a high epa omega 3 fish oil supplement, containing 2500 mg of fish oil, far exceeding competitor's fish oil 1200 mg servings. This omega 3 fatty acid supplement is perfect for heart circulation and brain health, supports a healthy immune system, and contributes to radiant skin and hair.
- Myriad of Health Benefits: Omega-3 fatty acids are vital to maintain healthy cardiovascular and eye function. Omega 3 fish oil supports cognitive function, improving memory, focus, and overall brain health. In addition, its overall calming properties on the body can alleviate joint stiffness, enhancing long term mobility and flexibility in aging adults.
- 30 Day Supply: Each bottle of Luma Nutrition's burpless fish oil pills last for a month to maintain optimal freshness and provide strong daily support straight from nature. This all natural cardiovascular and joint support supplement makes the perfect monthly subscription for men and women. Stay in stock and save money at the same time!
- Made in the USA by Veteran-Owned Small Business: Trust in Luma Nutrition's GMP certified, USA-manufactured supplements that are 3rd party verified. As a veteran-owned brand, we prioritize quality and expert craftsmanship to assist with your health journey.
With an impressive 2500mg of omega-3s per serving, this extra-strength formula delivers 1400mg EPA and 1000mg DHA for comprehensive cardiovascular support.
Research on omega-3s and AFib shows they support healthy inflammatory responses and cellular membrane stability in heart tissue. This concentrated formula provides therapeutic levels of both EPA and DHA, the two most important omega-3 fatty acids for heart health.
What We Like
- Extra-strength 2500mg formula provides clinical doses
- High EPA content specifically supports cardiovascular health
- Molecularly distilled for purity and freshness
What Could Be Better
- Requires multiple large softgels per serving
- Premium dosing means higher cost per month
Bottom Line: A powerful omega-3 supplement for those serious about supporting heart health with therapeutic-level doses.
4. ZEBORA CoQ10 300mg with PQQ – Best Mid-Range Option
- ENHANCED COQ10 WITH PQQ: Our CoQ10 300mg, with a 120-day supply, boosts natural CoQ10 levels for heart health. Combined with PQQ, it enhances mitochondrial energy production, vital for efficient energy and optimal heart function
- HIGH BIOAVAILABILITY: ZEBORA CoQ10 is enhanced with Black Pepper Extract and Sunflower Lecithin for superior absorption and bioavailability. Black Pepper offers antioxidant benefits, while sunflower lecithin supports skin and liver health
- OPTIMAL COMBINED OMEGA-3: Every Coq10 softgel contains 60 mg of omega-3s, which are imperative to promoting heart health. Omega-3s can improve sleep quality, support the eyes, skin, and brain health. Better absorption, better taste, and no fishy burps
- BENEFITS FOR STATIN USERS: CoQ10 is crucial for producing 95% of your body's energy, but levels decline with statin use. Supplementing with CoQ10 during statin therapy helps replenish lost levels, supporting energy production and overall organ function
- NATURAL AND PURE: All our products are third-party tested and are manufactured in a cGMP-certified facility. No Artificial Flavors or Sweeteners, No Sugar, No Starch, No Gluten, No Soy, No Wheat, and Sodium-free
This 300mg formula hits the sweet spot between the standard 100-200mg doses and higher-potency options, enhanced with PQQ and BioPerine.
For many people with AFib, 300mg of CoQ10 daily provides optimal support without over-supplementation. The addition of PQQ helps protect and create new mitochondria, which is crucial for maintaining heart muscle energy.
What We Like
- 300mg dose provides strong support without excess
- PQQ supports mitochondrial biogenesis
- BioPerine enhances absorption of fat-soluble CoQ10
What Could Be Better
- May not be sufficient for those needing maximum doses
- Combination formula costs more than basic CoQ10
Bottom Line: An ideal middle-ground option for those wanting more than basic CoQ10 supplementation but not needing maximum strength.
5. NATURE TARGET CoQ10 300mg Plus PQQ – Best for Absorption
- SUPPORTS HEART HEALTH - Nature Target USP Grade CoQ10 300mg softgels are naturally sourced, used by many people to protect heart health and improve heart function. POWERFUL ANTIOXIDANT helps you protect cells against damage.
- BETTER ABSORPTION WITH ORGANIC OLIVE OIL - Our CoQ10 liquid softgels are 100% fat-soluble, including 100% natural organic olive oil high in antioxidants to improve overall health. Clinical trials have proven that organic olive oil helps Coenzyme Q10 be better absorbed by the body and support your heart health.
- ESSENTIAL FOR ENERGY & IMMUNE SUPPORT - CoQ10 supplement increases your cellular energy production. UTCAM reports that CoQ10 provides good results for the immune system through anti-oxidant. Helpful for muscle or nerve problems caused by CoQ10 deficiency, enhance immunity and improve energy.
- BENEFICIAL TO STATIN DRUG USERS - Natural CoQ10 levels drop with age or when taking statin medications. while statin drugs may deplete the body’s CoQ10 levels. Nature Target CoQ10 300mg supplement helps you to quickly restore your body’s CoQ10 to ideal levels.
- NOTHING TO LOSE! - Before that bottle arrives at your location, it goes through stringent third-party testing that includes testing the materials and ensuring purity and potency. Contains one 120 Count bottle of our CoQ10 300 mg Softgels for a 120-day supply. No artificial flavors, no preservatives, and no color added.
By combining CoQ10 with organic olive oil, this formula ensures maximum absorption of this fat-soluble nutrient.
CoQ10 needs fat for proper absorption, and this formula eliminates guesswork by including organic olive oil in each softgel. The polyphenols in olive oil may provide additional cardiovascular benefits.
What We Like
- Organic olive oil base maximizes CoQ10 bioavailability
- 300mg provides therapeutic dosing for heart support
- PQQ addition enhances mitochondrial function
What Could Be Better
- 60-count bottle requires monthly reordering
- Oil-based softgels may not suit everyone’s preferences
Bottom Line: A smart formulation that prioritizes absorption to ensure you get the full benefit of CoQ10 supplementation.
6. NATURELO Vitamin D3 K2 5000 IU – Best for Vitamin D Support
- BETTER TOGETHER: Vitamin D3 and K2 are perfect partners that work together to help your body absorb and use calcium properly, so that it goes into your bones -- and away from your arteries and soft tissues.*
- HEALTHY BONES & HEART: Vitamin D3 + K2 work together to support healthy bone density and healthy blood vessels for healthy circulation.* If you take calcium, adding D3 + K2 will support healthy calcium metabolism.*
- PLANT-BASED D3: Most Vitamin D3 supplements are made from lanolin secreted from sheep skin. Our vegan D-3 is completely plant-based and sustainably sourced from wild-harvested lichen.
- ACTIVE K2: Vitamin K2 as MK-7, a bioactive form of the vitamin that shows better bioavailability in humans and has well researched benefits for healthy bone building.*
- CLEAN LABEL: Made in a GMP compliant facility. Non GMO, vegetarian, vegan, and gluten free. Does NOT contain soy, dairy, yeast, eggs, nuts, caffeine, preservatives, or coloring.
This plant-based formula combines vegan D3 with vitamin K2 to support cardiovascular health and proper calcium metabolism.
Research suggests vitamin D deficiency may be linked to increased AFib risk. This formula provides 5000 IU of vegan D3 from lichen plus 100mcg of vitamin K2 MK-7 to ensure calcium goes to bones rather than arteries.
What We Like
- Plant-based D3 from lichen suitable for vegans
- K2 MK-7 directs calcium to proper tissues
- 5000 IU dose addresses common deficiency
What Could Be Better
- High dose requires monitoring of vitamin D levels
- Not suitable for those already D3 sufficient
Bottom Line: An excellent D3/K2 combination for supporting cardiovascular health through proper calcium and vitamin D metabolism.
7. CoQ10 600mg Extra Strength Softgels – Best Maximum Strength
- Extra Strength CoQ10 600mg Softgels Supplement: The ZEBORA coenzyme q10 product features an exceptionally high content of 600mg(q10). Compared with the regular dosages of coq10 100mg, coq10 200mg, coq10 300mg and coq10 400mg, clearly our coq10 600mg contains a significantly higher amount. Therefore, it suits conventional needs and better caters to those with a higher demand for coq10 content
- Optimal Combined Omega-3 & PQQ: Omega-3s can improve sleep quality, support the eyes, skin, and brain health. PQQ will increase ATP production, their combination with coq10 provides support for energy production. ZEBORA coenzyme q10 nutritional supplements added an extra 90mg Omega-3s, 10mg PQQ per serving, which are imperative to promoting heart health
- Ultra Absorption Black Pepper & Sunflower Lecithin: Ubiquinol and ubiquinone are continuously cycle-converted in the body, our COQ10 is blended with BioPerine and Sunflower Lecithin to enhance the absorption and bioavailability. Black Pepper is not only a bioavailability enhancer; it also has potent antioxidant properties. In addition, Sunflower Lecithin is safer than other sources of Lecithin as it has been shown to help with skin health and improve liver function
- Why CoQ10 is Needed: CoQ10 plays a vital role in producing 95% of the energy used by our organs. As we age, coenzyme q10 levels in the heart and body begin to naturally decline. Medications for statin drug users have been proven to reduce coq10 levels. In addition, people who exercise regularly or do physical labor, due to high physical exertion, have a high demand for cellular energy. These all affect heart and brain function
- Natural Ingredients Trusted Source: All our products are third-party tested and manufactured in a cGMP-certified facility. ZEBORA COQ10 supplement No Artificial Flavors or Sweeteners, No Preservatives, No Sugar, No Starch, No Gluten, No Soy, No Wheat, Sodium-free, Dairy-free and Non-GMO
For those needing the highest CoQ10 doses, this 600mg formula delivers maximum support with PQQ and omega-3s.
Some individuals with AFib, particularly those on statin medications which deplete CoQ10, may benefit from higher doses. This extra-strength formula provides 600mg per serving with synergistic ingredients.
What We Like
- 600mg provides maximum therapeutic dosing
- Includes PQQ and omega-3s for comprehensive support
- High potency may reduce number of supplements needed
What Could Be Better
- Very high dose may be more than most people need
- Premium strength comes with premium pricing
Bottom Line: The strongest option for those requiring maximum CoQ10 support, particularly if on medications that deplete it.
8. Quick Absorption CoQ10 400mg – Best High-Dose Value
- Precision Dosage: Our CoQ10 supplement is made with high absorption and stable CoQ 10 400mg per serving from ubiquinone so you get more out of every capsule
- Why Ubiquinone: Get the most out of each dose with our CoQ10 nutritional supplements made with a more stable form in our easy to swallow capsules for even better nutrient absorption
- The Clear Difference: At Clear Formulas we believe transparency and trust are essential which is why our product is made in an FDA inspected American facility according to strict regulatory guidelines
- Made for All in Mind: We stand by our name and our formula is made without many common allergens and additives including corn, dairy, gluten, salt, or artificial preservatives and flavors
- The Choice is Clear: We believe health doesn't have to be hard - We make it simple with carefully designed supplements to support your needs whatever your age and lifestyle we've got you covered
This high-potency formula delivers 400mg of quickly-absorbed CoQ10 without the premium price tag of combination formulas.
If you’re looking for a strong CoQ10 dose but don’t need additional ingredients, this streamlined formula provides 400mg with enhanced absorption technology at a competitive price point.
What We Like
- 400mg provides strong therapeutic support
- Quick absorption technology enhances bioavailability
- Focused formula without extra ingredients keeps costs down
What Could Be Better
- Lacks synergistic ingredients like PQQ or omega-3s
- 60-count requires more frequent ordering
Bottom Line: A solid high-dose CoQ10 option for those who want to add other supplements separately rather than a combination product.
How to Choose the Best Supplement for AFib
When selecting supplements to support AFib management, start with those that have the most research backing. CoQ10 is one of the most studied nutrients for heart health, particularly for energy production in cardiac tissue. Your heart muscle has among the highest concentrations of mitochondria in the body, and CoQ10 is essential for these cellular powerhouses to function properly.
Omega-3 fatty acids have mixed but generally positive evidence for AFib. The key is choosing a high-quality product with adequate EPA and DHA – typically you want at least 1000-2000mg of combined EPA/DHA daily. Look for products in triglyceride form rather than ethyl ester form, as triglycerides are better absorbed and more similar to the natural form found in fish.
Magnesium deficiency is common and can contribute to irregular heart rhythms. If you’re considering magnesium supplementation, choose forms like glycinate or threonate that are well-absorbed and less likely to cause digestive upset. Many people with AFib find 200-400mg of elemental magnesium daily helpful, but always start low and increase gradually.
Quality markers matter significantly when choosing supplements for heart health. Look for third-party testing from organizations like USP or NSF, GMP certification, and transparency about ingredient sourcing. For fish oil specifically, check that products are tested for heavy metals, PCBs, and oxidation.
Consider your medication regimen when selecting supplements. If you’re on blood thinners, fish oil may increase bleeding risk. If you’re on statins, you almost certainly need CoQ10 supplementation as statins deplete this nutrient. Work closely with your healthcare provider to ensure supplements won’t interfere with your AFib medications.
Benefits of Supplements for AFib
CoQ10 supplementation helps address the energy deficit that often occurs with AFib. Your heart muscle needs enormous amounts of cellular energy to maintain proper rhythm, and CoQ10 is essential for this energy production. Studies have shown that people with heart conditions often have lower CoQ10 levels, and supplementation may help restore optimal function.
Omega-3 fatty acids influence heart rhythm through multiple mechanisms. They become incorporated into cell membranes, affecting electrical signaling and reducing susceptibility to irregular rhythms. The anti-inflammatory effects of EPA and DHA may also play a role in maintaining normal heart function.
Maintaining adequate magnesium levels supports normal electrical conduction in the heart. Magnesium acts as a natural calcium channel blocker and helps regulate the movement of ions that control heartbeat. Some research suggests that magnesium supplementation may help reduce AFib episodes in people who are deficient.
Vitamin D deficiency has been associated with increased AFib risk in some studies. Vitamin D receptors are present in cardiac tissue, and this vitamin may play a role in heart muscle function and rhythm stability. Pairing D3 with K2 ensures proper calcium metabolism, directing calcium to bones rather than soft tissues.
Frequently Asked Questions
Can supplements cure AFib?
No, supplements cannot cure AFib. Atrial fibrillation is a medical condition that requires proper diagnosis and treatment by a healthcare provider. Supplements may help support overall cardiovascular health and potentially reduce some AFib symptoms when used as part of a comprehensive treatment plan, but they’re not a replacement for medical care. Always work with your doctor to manage AFib.
How much CoQ10 should I take for AFib?
Most studies on CoQ10 for cardiovascular health use doses between 100-300mg daily, with some going up to 400-600mg. If you’re on statin medications, which significantly deplete CoQ10, higher doses may be beneficial. Start with 100-200mg and work with your healthcare provider to determine the optimal dose for your situation. Take CoQ10 with meals containing fat for better absorption.
Are omega-3 supplements safe with blood thinners?
High doses of omega-3 supplements (above 3 grams daily) may increase bleeding risk when taken with blood thinners like warfarin or newer anticoagulants. However, moderate doses around 1000-2000mg daily are generally considered safe. It’s crucial to inform your doctor about all supplements you’re taking, especially if you’re on anticoagulants for AFib. Your doctor may need to monitor your INR more closely if you’re on warfarin.
Should I take magnesium if I have AFib?
Magnesium can be beneficial for some people with AFib, particularly if you’re deficient. However, you should discuss magnesium supplementation with your doctor, especially if you have kidney disease or are on certain medications. Typical doses range from 200-400mg of elemental magnesium daily, preferably in glycinate or threonate form. Too much magnesium can cause digestive issues and other problems, so proper dosing is important.
Can vitamin D help prevent AFib episodes?
Research on vitamin D and AFib shows mixed results, but some studies suggest that vitamin D deficiency may increase AFib risk. If you’re deficient in vitamin D (which is common), supplementation may be helpful as part of your overall heart health strategy. However, there’s no evidence that vitamin D can prevent AFib episodes in people who already have adequate levels. Testing your vitamin D levels before supplementing is wise.
How long before supplements help with AFib symptoms?
The timeline varies considerably depending on the supplement and your individual situation. If you’re severely deficient in a nutrient like magnesium or CoQ10, you might notice some improvement within a few weeks. However, for most people, it takes 2-3 months of consistent supplementation to see meaningful effects. Supplements work best as part of a comprehensive approach including medication, lifestyle changes, and stress management.
Can I stop my AFib medication if supplements work?
Absolutely not. Never stop taking prescribed AFib medications without explicit guidance from your doctor. AFib medications serve critical purposes – some control heart rate, others help prevent stroke through anticoagulation. Supplements are meant to complement, not replace, medical treatment. If you’re interested in reducing medications, discuss this goal with your cardiologist who can safely adjust your treatment plan if appropriate.
What supplements should I avoid with AFib?
Some supplements can worsen AFib or interact with AFib medications. Stimulants like high-dose caffeine supplements, ephedra, or bitter orange should be avoided. Some herbs can affect heart rhythm or interact with blood thinners. Always inform your doctor about every supplement you’re taking. If you experience increased palpitations or other symptoms after starting a new supplement, discontinue it and consult your healthcare provider.
