Best Supplements for Amenorrhea (2026) – Top 10 Reviewed
Amenorrhea, the absence of menstrual periods, affects women for various reasons ranging from functional hypothalamic amenorrhea (FHA) caused by stress, under-eating, or excessive exercise, to hormonal imbalances like PCOS, thyroid disorders, or elevated prolactin. While supplements alone cannot replace the fundamental lifestyle changes needed to restore periods—particularly adequate nutrition and reduced stress—targeted nutrients can support hormonal balance, bone health, and the recovery process when combined with proper treatment of the underlying cause.
Our Top Picks at a Glance
- Best for Bone Health: Calcium and Vitamin D3 – essential for preventing bone loss during amenorrhea
- Best Herbal Support: Pink Stork Organic Vitex – helps restore hormonal communication
- Best for PCOS-Related Amenorrhea: Myo-Inositol & D-Chiro Inositol – supports ovulation restoration
Quick Comparison
| Product | Key Ingredients | Form | Servings | Best For |
|---|---|---|---|---|
| Calcium with Magnesium | Calcium, Magnesium, Vitamin D | Capsules | 90 | Bone health |
| Pink Stork Organic Vitex | 1000mg Chaste Tree Berry | Capsules | 60 | Hormonal regulation |
| Myo-Inositol & D-Chiro Inositol | 40:1 Inositol Ratio | Capsules | 60 | PCOS amenorrhea |
| Liquid Iron Blood Builder | Liquid Iron, B12, Folate | Liquid | 60 | Iron deficiency |
| SAMe with B Vitamins | SAMe 200mg, B6, B12, 5-MTHF | Capsules | 60 | Mood and stress |
| Ovarian Support with NAC | Myo-Inositol, Vitex, NAC | Capsules | 60 | Ovulation support |
| Pink Stork Hormone Balance | Vitex, Saffron, Ashwagandha, Magnesium | Capsules | 60 | Overall hormone support |
| Pink Stork Perimenopause Support | Ashwagandha, Maca Root, Black Cohosh | Capsules | 60 | Hormone transitions |
| Myo-Inositol with Choline | Myo-Inositol, D-Chiro, Choline | Capsules | 60 | Menstrual regulation |
| PCOS Queen Period Repair | B Vitamins, Zinc, Dong Quai, Ashwagandha | Capsules | 60 | PCOS management |
1. Calcium with Magnesium – Best for Bone Health
- GUM & TEETH HEALTH SUPPORT – Support your daily gum care routine with Strong Jaw Gum Restore, made to support gum health, teeth health, and overall dental wellness. Formulated with key nutrients and gums vitamins. It’s a great choice for those looking for gum health supplements to support receding gums, gum for teeth health and lasting oral health.
- GUM VITAMINS FORMULA – Our gum supplements are made with teeth and gum vitamins to support everyday oral health and gum health. This formula is carefully designed to support strong gum function and for daily gum care. A great option for anyone seeking dental vitamins for adults to support gums health, teeth strength, and overall teeth health.
- STRONG JAW GUM RESTORE BLEND – Crafted for daily gum care, this Strong Jaw supplement combines key vitamins for teeth and gums to support receding gums and maintain gum health. A smart addition to any dental health routine, it’s designed to support gum growth and overall teeth wellness. Great for keeping gums healthy as part of a consistent oral care routine.
- QUALITY DENTAL VITAMINS & SUPPLEMENTS – Made in the USA, our gum health supplements deliver premium gums vitamins and teeth vitamins without GMOs or artificial additives. Designed to complement your dental supplements and gum care products, this formula supports gum oral care and helps maintain teeth health with thoughtfully selected ingredients.
- EVERYDAY GUM & TEETH SUPPORT – Add Strong Jaw Gum Restore to your daily routine to support gum care and teeth health. This formula supports efforts to strengthen gums and maintain overall oral care with carefully selected dental vitamins and teeth supplements. A great addition for anyone focused on gum health, good gums, and lasting oral health.
This combination of calcium, magnesium, and vitamin D is critical for protecting bone density during amenorrhea, when the lack of estrogen puts you at high risk for osteoporosis.
Prolonged amenorrhea causes accelerated bone loss that cannot be reversed later, making calcium and vitamin D supplementation absolutely essential even before your periods return. Research shows that women with amenorrhea lose bone density at rates similar to postmenopausal women. The recommended intake is 1200mg of calcium daily plus 400-800 IU of vitamin D3, though higher doses may be needed if you’re deficient.
What We Like
- Essential for preventing irreversible bone loss
- Magnesium improves calcium absorption
- Vitamin D supports both bone and hormone health
- Critical protection while working on underlying causes
What Could Be Better
- Doesn’t address the root cause of amenorrhea
- Requires consistent daily use for bone protection
Bottom Line: Non-negotiable for anyone with amenorrhea—protecting your bones is critical while addressing the underlying cause of missing periods.
2. Pink Stork Organic Vitex – Best Herbal Support
- Helps maintain healthy hormone patterns during perimenopause, monthly changes, and beyond. Each 1000 mg serving of Organic Vitex Chaste Tree Berry works with your body’s natural rhythm to support cycle regularity, balanced hormone levels, and overall hormonal harmony. Designed for women embracing life’s natural transitions in their 30s, 40s, and 50s. We understand that perimenopause can feel unpredictable—our goal is to offer gentle, reliable support so you can feel more in control and at ease. Always vegan, non-GMO, gluten-free, and crafted in cGMP facilities for quality you can trust.
- Designed for women navigating hormonal changes, our Vitex formula offers gentle, plant-based support for life’s natural transitions. It helps ease the journey through perimenopause by supporting comfort during cycle changes, occasional hot flashes, and evolving monthly patterns. Works in harmony with your body to help you feel more in sync—suitable for long-term use as part of a holistic wellness plan.
- Vitex, also known as Chaste Tree Berry, has been traditionally used for centuries in herbal wellness practices to help women stay in tune with their natural rhythms. We only use pure, organic Vitex Berry (Agnus Castus)—nothing more, nothing less. Our concentrated herbal formula delivers consistent, science-informed support for hormonal wellness, without synthetic additives or hidden ingredients. Every batch is third-party tested for purity and potency, so you get exactly what’s promised—clean, trusted support for daily balance.
- Unlike some competitors with complex blends and higher prices, we keep it simple: one powerful ingredient, Vitex, at a research-backed potency and price point designed for long-term daily support. Vegan, gluten-free, lactose-free, soy-free, and non-GMO, for clean, everyday confidence. Take daily as part of your morning wellness ritual—easy to add alongside your tea, smoothie, or vitamins for a consistent, mindful start to the day.
- This Vitex supplement pairs perfectly with our menopause, PMS, and multivitamin products, creating a complete women’s wellness toolkit. Every product is crafted with care, informed by science, and inspired by our mission: to help women feel supported, confident, and empowered through every season of life.
Chasteberry (vitex) works on the pituitary gland to help normalize hormone signaling, making it useful for amenorrhea caused by elevated prolactin or hormonal miscommunication.
Vitex has been traditionally used for centuries to restore menstruation and has research backing for reducing elevated prolactin levels and helping regulate the menstrual cycle. It’s particularly beneficial for amenorrhea not caused by severe caloric restriction or excessive exercise. The organic formulation provides 1000mg per serving without pesticides or additives.
What We Like
- USDA organic certification ensures purity
- Helps normalize pituitary-ovarian communication
- Can reduce elevated prolactin levels
- Long history of traditional use for amenorrhea
What Could Be Better
- Requires 3-6 months to see effects
- Not effective for hypothalamic amenorrhea from undereating
Bottom Line: A valuable herbal support for certain types of amenorrhea, particularly when hormonal signaling disruption is the primary issue.
3. Myo-Inositol & D-Chiro Inositol – Best for PCOS Amenorrhea
- WOMEN’S HORMONE BALANCE: Myo & D-Chiro Inositol is a premium women's hormone balance supplement with a blend of ingredients that work side-by-side to support women’s reproductive health and restore balance to the monthly cycle.*
- IDEAL 40:1 RATIO: Our inositol pills are formulated to match the body’s normal ratio of 40:1, with Myo Inositol 2000mg and D-Chiro Inositol 50mg powder per serving.
- OVARIAN SUPPORT VITAMINS & MENSTRUAL SUPPORT: By working together to support hormone balance, Myo Inositol and D Chiro Inositol encourage healthy ovulation and regular, more comfortable menstrual cycles.*
- MYO-INOSITOL & D-CHIRO INOSITOL: The benefits of a Myo and D-Chiro Inositol supplement extend beyond ovarian health supplements! By supporting your body’s healthy hormone rhythms, this formula can help with energy, bloating, skin health, and more.*
- 60-DAY SUPPLY: Myo D-Chiro Inositol by SMNutrition is Vegan, Hormone-Free, and formulated Gluten-Free and Non-GMO. It is Third-Party Tested, formulated without the top 9 allergens, and manufactured in a facility that is certified GMP compliant with NSF standards.
For women whose amenorrhea is caused by PCOS, this 40:1 ratio of inositol has clinical evidence for restoring ovulation and regular menstruation within 2-3 months.
Inositol improves insulin sensitivity, which is crucial for PCOS management and cycle restoration. Studies show that 70-80% of women with PCOS-related amenorrhea or oligomenorrhea (infrequent periods) restore regular ovulation with inositol supplementation. The 40:1 ratio of myo-inositol to d-chiro inositol mimics the body’s natural balance for optimal effectiveness.
What We Like
- Strong clinical evidence for PCOS amenorrhea
- Addresses insulin resistance, a root cause
- Supports ovulation restoration
- Natural, hormone-free approach
What Could Be Better
- Only effective for PCOS-type amenorrhea
- Not helpful for hypothalamic amenorrhea
Bottom Line: The gold standard supplement for women with PCOS-related amenorrhea, backed by extensive research for restoring menstruation.
4. Liquid Iron Blood Builder – Best for Iron Deficiency
- 𝐈𝐫𝐨𝐧: Easily absorbed form of iron supplement, essential for maintaining healthy blood cells and preventing iron deficiency anemia, promoting energy levels and overall health
- MCT OIL - The body absorbs MCTs more rapidly than long-chain triglycerides (LCTs); Due to their shorter chain length, MCTs travel more quickly from the gut to the liver
- All our vitamins are Non-GMO, Gluten-Free, Vegan-Friendly, made in GMP & FDA certified facility, therefore you can be confident in the quality of our products
- Iron is an important component of hemoglobin, the substance in red blood cells that carries oxygen from your lungs to transport it throughout your body
Despite not menstruating, many women with functional hypothalamic amenorrhea have iron deficiency that can impair thyroid function and worsen metabolic suppression.
Iron is essential for thyroid hormone production and metabolism. Low iron status can impair thyroid function, which is already often compromised in hypothalamic amenorrhea due to low energy availability. This liquid formula provides gentle, easily-absorbed iron with B12 and folate to support overall recovery without the constipation common with iron pills.
What We Like
- Liquid form absorbs quickly and gently
- Supports thyroid and metabolic function
- Includes B12 and folate for comprehensive support
- Minimal digestive side effects
What Could Be Better
- Taste may not appeal to everyone
- Requires refrigeration after opening
Bottom Line: An important supplement for amenorrhea recovery, particularly for athletes or women with hypothalamic amenorrhea who may be iron deficient.
5. SAMe with B Vitamins – Best for Stress and Mood
- Immune And Hormone Support - S-Adenosylmethionine or SAMe is a naturally occurring compound found in the human body as well as in plant and animal foods. It is involved in many processes throughout the body. SAMe plays a role in supporting the immune system and maintaining cell membranes, the protective barrier that surrounds all cells. It also helps to produce neurotransmitters like melatonin- that helps with your body's rest cycle, and serotonin, the "feel good" hormone. *
- Includes Necessary Cofactors - Each capsule provides 200 mg of SAMe along with vitamins B6, B12, and folate as 5-MTHF to provide cofactors for the natural conversions of SAMe to L-homocysteine and then safely to L-cysteine. *
- Special Technology - Our SAMe capsules are made using special technology with a patented stabilized powder which protects the SAMe from being destroyed by air and moisture. This cutting-edge technology prevents its breakdown by stomach acidity and allows the capsule to be absorbed intact in the small intestine. *
- Always Pure & Effective Products - This product is Vegetarian-Friendly, Non-GMO, and contains No Gluten, Dairy, or Soy.*
- Clinically-Trusted Care - DFH is the #1 practitioner supplement brand recommended by functional medicine professionals and the #1 practitioner supplement brand personally trusted by functional medicine professionals.**
SAMe supports both mood and energy metabolism, which is crucial for recovery from hypothalamic amenorrhea where stress and low mood often perpetuate the condition.
Hypothalamic amenorrhea is often accompanied by elevated stress hormones and disrupted neurotransmitter function. SAMe helps produce serotonin and dopamine naturally, supporting improved mood and stress resilience. The combination with methylated B vitamins (B6, B12, 5-MTHF) enhances effectiveness for both mood and energy support.
What We Like
- Supports mood and stress management
- Methylated B vitamins enhance benefits
- Helps with energy and motivation
- Quality manufacturing standards
What Could Be Better
- Higher price point than basic B vitamins
- Not a complete solution for amenorrhea
Bottom Line: A valuable supportive supplement for women whose amenorrhea is linked to stress, depression, or anxiety, helping address the psychological component of recovery.
6. Ovarian Support with NAC – Best for Ovulation Support
- HORMONE BALANCE FORMULA: Feel more in sync with your body. Our blend of ovarian support vitamins provides support for regular, comfortable periods, hormonal acne, fatigue, and mood swings, by supporting your own healthy hormone rhythms.*
- HEALTHY OVULATION: Supporting your ovarian health promotes menstrual cycle regularity and normal ovarian function. Enhanced with added folate, our Ovarian Support Complex offers reproductive health and fertility support, too.*
- FORMULATED WITH DIM: Diindolylmethane is a well-studied compound found in cruciferous veggies like broccoli. By encouraging your body to balance excess estrogen, DIM provides targeted PMS, bloating, and hormonal acne support.*
- INOSITOL SUPPLEMENT: Our Ovarian Support capsules are formulated with the ideal Myo Inositol & D Chiro Inositol 40:1 ratio for optimal ovarian health.* This is the inositol supplement happy hormones deserve!
- ONE MONTH SUPPLY: Ovarian Support Complex by SMNutrition is formulated Non-GMO, Third-Party Tested, and manufactured in a facility that is certified GMP compliant with NSF standards.
This combination of myo-inositol, vitex, and NAC provides comprehensive support for restoring ovulation and healthy menstrual cycles.
NAC (N-acetyl cysteine) is a powerful antioxidant that has been shown to improve egg quality and support ovulation, particularly beneficial for women with PCOS or ovulatory dysfunction. Combined with myo-inositol for metabolic support and vitex for hormonal regulation, this formula addresses amenorrhea from multiple angles.
What We Like
- NAC supports ovulation and egg quality
- Triple-action formula for ovarian health
- Beneficial for multiple types of amenorrhea
- Supports fertility alongside cycle restoration
What Could Be Better
- Premium price for comprehensive formula
- Best combined with lifestyle modifications
Bottom Line: An excellent comprehensive supplement for women trying to restore both menstruation and fertility, particularly with PCOS or ovulatory issues.
7. Pink Stork Hormone Balance – Best 18-in-1 Formula
- 18-in-1 Formula for Comprehensive Hormonal Support: Designed to support hormone harmony for women at every stage, this daily multivitamin delivers 100% DV of Vitamin B6, B12, and Iron, plus 825 mg of Vitex and Ashwagandha. Take 2 capsules daily, best with food.
- Mood, Stress, + Adrenal Support: Magnesium and Ashwagandha work together to help maintain calm energy. Includes a light berry-scented insert so your supplements smell as good as they make you feel.
- All-in-One Multivitamin + Herbal Hormone Formula: Delivers Iron, Vitamin D3, and B Vitamins for cognitive function and immune health. Replaces multiple bottles with two easy-to-swallow capsules.
- Monthly PMS + Period Support: Hormone harmony for women to ease bloating and irritability. Helps to balance estrogen and other key hormones for cycle regularity.
- Perimenopause + Hormone Transition Support: Supports perimenopause fluctuations with Dong Quai and Black Cohosh. Helps with hot flashes and mood stability.
This comprehensive formula combines vitex, saffron, ashwagandha, and magnesium to support hormone balance from multiple angles when the cause of amenorrhea isn’t entirely clear.
The 18 ingredients provide broad-spectrum support: vitex for pituitary-ovarian communication, ashwagandha for stress management, saffron for mood, and magnesium for metabolic function. This multi-targeted approach can be helpful when amenorrhea has multiple contributing factors.
What We Like
- 18 ingredients provide comprehensive support
- Addresses stress, hormones, and mood simultaneously
- Convenient all-in-one approach
- Includes adaptogenic herbs for stress resilience
What Could Be Better
- Higher price for premium formula
- May not address severe hypothalamic amenorrhea alone
Bottom Line: A good option for women with mild to moderate amenorrhea who want comprehensive support without taking multiple different supplements.
8. Pink Stork Perimenopause Support – Best for Hormonal Transitions
- Targeted Hormone Support for Women: Support your body’s natural hormone balance through perimenopause with nine trusted herbs: Ashwagandha, Maca Root, Black Cohosh, Dong Quai, Chasteberry (Vitex), Red Clover, Milk Thistle, Red Raspberry Leaf, and Black Pepper Extract. This clean, plant-based formula is designed to support hormonal balance, energy, and mood through every stage of your perimenopause transition.
- Natural Adaptogens + Hormone Balance Herbs: Our blend combines ancient adaptogens used for centuries to support balance and vitality. Ashwagandha helps the body adapt to everyday stress. Maca Root provides botanical support for women’s natural hormonal rhythms. Black Cohosh for menopause symptoms. Dong Quai and Chasteberry for cycle harmony. Support heathy cortisol and adrenal function without synthetic hormones.
- Mood, Energy + Emotional Wellness Support: Perimenopause doesn’t have to mean imbalance. These ingredients work together to help maintain calm energy, balanced mood, and overall well-being—so you can feel like yourself again. Crafted to ease hot flashes, mood swings, night sweats, irregular periods, occasional irritability, menopause mood swings, and support overall hormonal harmony. Take consistently for 90 days for the best results. Not for use while pregnant or breastfeeding.
- Clean, Conscious, and Expert-Backed Formula: Unlike synthetic medications, this formula is made with high-quality, plant-based ingredients and free from GMOs, gluten, dairy, soy, and artificial flavors. Each vegan capsule is carefully formulated by experts in women’s wellness to support your natural hormonal transition. Third-party tested for purity and manufactured in the USA. These hormone balance capsules are a trustworthy part of your wellness routine — no synthetic hormones, no unnecessary fillers. No refrigeration needed.
- Women-Owned + Trusted by Women Everywhere: Pink Stork is women-owned and women-run, creating trusted supplements designed to empower every stage of womanhood. — from PMS to perimenopause and beyond. We’re over 80% women-led and deeply committed to creating clean, effective solutions that support your body's natural rhythm. Pair with our Wild Yam Cream for additional hormonal support, women’s probiotics for gut and mood balance, or multivitamins for a holistic wellness routine. Consult your healthcare professional for guidance when using with medications.
For women approaching perimenopause whose amenorrhea signals hormonal transition, this formula with ashwagandha, maca root, and black cohosh provides appropriate support.
Black cohosh has phytoestrogenic properties that may help when amenorrhea is caused by declining estrogen levels. Maca root supports overall hormonal balance, while ashwagandha helps manage the stress that can worsen perimenopausal symptoms. This formula is specifically designed for women in hormonal transition.
What We Like
- Appropriate for perimenopausal amenorrhea
- Black cohosh provides phytoestrogenic support
- Ashwagandha helps with stress and sleep
- Addresses multiple transition symptoms
What Could Be Better
- Not appropriate for younger women or FHA
- May take 2-3 months to see effects
Bottom Line: An excellent choice for women over 40 whose missing periods may signal the transition to perimenopause rather than other causes.
9. Myo-Inositol with Choline – Best for Metabolic Support
- Many Names Same Great Product - Inositol can go by names like myoinositol vitamin B8 or myo inositol, our product contains 2 forms of this specialized ingredient for health benefits
- Fertility Supplement for Women - Not all female fertility supplements can help achieve hormonal balance for women but this unique blend may help with fertility health and promote cycle balance
- Cycle Support - Anyone looking for a healthy cycle can benefit from our inositol and choline supplement that can also promote healthy and normal ovulation and even help assist in monthly mood support
- Clean Formula - Get the great benefits without the not so great additives with our potent vegan myo and D-chiro inositol and choline supplement made in the USA with globally sourced ingredients
- Natures Craft Quality - We are proud to be a leading name in female hormone balance supplements and prenatal vitamins for women because we believe in family values and want your family to grow
This formula combines myo-inositol and d-chiro inositol with choline for enhanced metabolic support and menstrual cycle regulation.
Choline is essential for cell signaling and hormone production, working synergistically with inositol to improve insulin sensitivity and support reproductive function. This combination is particularly beneficial for women whose amenorrhea is related to metabolic dysfunction or PCOS.
What We Like
- Choline enhances inositol’s effectiveness
- Supports cell signaling and hormone production
- Beneficial for metabolic health
- Helps regulate menstrual cycles
What Could Be Better
- More expensive than basic inositol
- May not be necessary for all types of amenorrhea
Bottom Line: A good enhanced option for women with PCOS or metabolic issues contributing to amenorrhea who want comprehensive metabolic support.
10. PCOS Queen Period Repair & Regulate – Best for PCOS Management
- HORMONAL BALANCE SUPPORT - PCOS Queen Period Repair & Regulate supplement is designed to support women's hormone balance, healthy periods, and reduced symptoms of PMS for anyone who needs some extra support for their monthly cycle.* Take two capsules daily for more than 30 days to achieve results.
- NATURAL INGREDIENTS - Find your balance and achieve a more regular, healthy menstrual cycle with reduced PMS symptoms thanks to this unique vegetarian blend. The formula includes B vitamins, Zinc, Tyrosine, Dong Quai, Ashwagandha, and other plant-based ingredients to promote estrogen and progesterone balance and provide healthy nutrients for healthy hormone production.*
- EMPOWERING ALTERNATIVE - Many frustrating and difficult symptoms of PCOS are related to imbalanced hormones, and natural options can provide powerful relief without the drawbacks of traditional approaches. This botanical formula can help women struggling with the management of irregular periods, restoring regularity while mitigating symptoms of hormonal acne, cramping, energy fluctuations, and more.*
- POTENT FORMULA - The carefully researched combination of ingredients in PCOS Queen’s Period Repair & Regulate supplement was created to synergize and promote women’s overall health and well-being, naturally. The powerful blend was created to minimize unwanted side effects while optimizing results.
- HIGH QUALITY & SAFE - PCOS Queen Period Repair & Regulate dietary supplement is manufactured under strict standards at our FDA-registered and GMP-certified facility in Colorado, USA. They are regularly inspected and verified by third-party quality control. The 100% natural formula is free of all gluten, soy, dairy, and GMOs.
This vegan formula targets PCOS-related amenorrhea with B vitamins, zinc, tyrosine, dong quai, and ashwagandha to support natural hormone production.
The combination addresses multiple aspects of PCOS: B vitamins and zinc for hormone synthesis, tyrosine for thyroid function (often impaired in PCOS), dong quai for circulation, and ashwagandha for stress and insulin resistance. This provides comprehensive support for restoring periods in women with PCOS.
What We Like
- Specifically formulated for PCOS amenorrhea
- Plant-based ingredients support hormone production
- Addresses thyroid function alongside hormones
- Stress-reducing adaptogens included
What Could Be Better
- Requires 30+ days minimum for results
- Works best with diet and lifestyle changes
Bottom Line: An excellent targeted option for women whose amenorrhea is specifically caused by PCOS, addressing the root hormonal and metabolic imbalances.
How to Choose the Best Supplements for Amenorrhea
Choosing supplements for amenorrhea must start with understanding why your periods have stopped. This is not something you should self-diagnose—work with your healthcare provider to rule out serious conditions like premature ovarian failure, pituitary tumors, or other medical issues requiring specific treatment.
If you have functional hypothalamic amenorrhea (FHA) from undereating, excessive exercise, or stress, understand that supplements cannot replace the fundamental requirements for recovery: eating more food, reducing exercise intensity/volume, and managing stress. Your body needs approximately 2500+ calories daily, adequate fat intake (at least 50g per day), and reduced physical stress to restore the hormonal environment needed for menstruation. Supplements can support this recovery but are not a shortcut.
Regardless of the cause of amenorrhea, calcium (1200mg daily) and vitamin D (800-1000 IU daily, or more if deficient) are absolutely essential. Prolonged amenorrhea causes rapid bone loss that may be irreversible, putting you at risk for osteoporosis and fractures even at a young age. This bone loss occurs regardless of whether you’re addressing the underlying cause, so bone protection must start immediately.
For PCOS-related amenorrhea, prioritize inositol supplements. The 40:1 ratio of myo-inositol to d-chiro inositol has the strongest evidence for restoring ovulation and menstruation in women with PCOS by improving insulin sensitivity. Most women see results within 2-3 months, with optimal benefits after 6 months of consistent use. Look for supplements providing at least 2000mg of myo-inositol and 50mg of d-chiro inositol daily.
For amenorrhea related to elevated prolactin or hormonal miscommunication (not FHA from undereating), consider vitex (chasteberry). This herb works on the pituitary gland to help normalize hormone signaling and has traditional and clinical evidence for restoring menstruation. However, it requires patience—expect 3-6 months of consistent use before seeing results.
Benefits of Supplements for Amenorrhea
When used appropriately alongside treating the underlying cause, supplements for amenorrhea offer several important benefits that support both recovery and long-term health.
The most critical benefit is bone protection during the amenorrheic period. Estrogen deficiency from missing periods causes bone loss at rates comparable to menopause, which is particularly devastating for younger women. Calcium and vitamin D supplementation, while not a complete solution, provides essential protection for your skeleton while you work on restoring your periods. This bone protection is time-sensitive—bone loss that occurs during amenorrhea may not be fully reversible even after periods return.
For PCOS-related amenorrhea, inositol supplementation addresses a root cause by improving insulin sensitivity. This doesn’t just help restore periods—it also reduces other PCOS symptoms like hormonal acne, unwanted hair growth, and difficulty losing weight. It also decreases your long-term risk of developing type 2 diabetes and cardiovascular disease, making it an investment in lifelong health beyond just menstrual restoration.
Supplements that support stress management and mood—like magnesium, SAMe, or ashwagandha—can help break the vicious cycle where amenorrhea causes stress, which then perpetuates the amenorrhea. Hypothalamic amenorrhea is both a physical and psychological condition, with stress hormones playing a key role in suppressing reproductive function. Supporting your mental health through this recovery process is as important as the physical interventions.
For women trying to conceive, supplements that support ovulation and egg quality (like NAC, CoQ10, and inositol) can help restore fertility alongside menstruation. Many women with amenorrhea eventually want to get pregnant, and addressing both cycle restoration and fertility simultaneously can reduce the time to conception once periods return.
Frequently Asked Questions
Can supplements alone restore my period if I have amenorrhea?
It depends on the cause. For PCOS-related amenorrhea, inositol supplements combined with lifestyle modifications can effectively restore periods in 70-80% of cases. However, for functional hypothalamic amenorrhea (FHA) from undereating or overexercising, supplements cannot replace the need for adequate food intake and reduced exercise—these are the fundamental requirements. For FHA, supplements support recovery but eating more and resting more are non-negotiable. For other causes like pituitary tumors or premature ovarian failure, medical treatment is necessary.
How long does it take for periods to return with supplement use?
Timeline varies by cause and individual factors. For PCOS amenorrhea with inositol, most women see menstruation return within 2-4 months if they’re also managing diet and lifestyle. For hypothalamic amenorrhea, even with perfect supplement use, recovery typically takes 3-6 months minimum and often up to 12 months, depending on how long you’ve been amenorrheic and whether you’re addressing all factors (eating enough, reducing exercise, managing stress). Vitex typically requires 3-6 months to show effects on menstruation.
Are supplements safe to take if I don’t know why my periods stopped?
You should never begin treating amenorrhea—with supplements or otherwise—without first consulting a healthcare provider for proper diagnosis. Amenorrhea can indicate serious conditions like pituitary tumors, premature ovarian failure, or chromosomal abnormalities that require specific medical treatment. Once you have a diagnosis, supplements can be added appropriately. Calcium and vitamin D are generally safe to start immediately for bone protection while you’re getting evaluated.
Will birth control pills help restore my natural period?
No. Birth control pills create artificial withdrawal bleeding but do nothing to restore your natural menstrual cycle. They suppress your body’s own hormone production, preventing recovery of natural cycles. Many women are prescribed birth control for amenorrhea, but this only masks the problem without addressing the underlying cause. The only exception is when birth control is medically necessary for another condition, but it should never be considered a treatment for amenorrhea itself.
Can I exercise while recovering from hypothalamic amenorrhea with supplements?
Exercise modification is crucial for hypothalamic amenorrhea recovery—supplements cannot compensate for excessive exercise. Most women need to reduce exercise to gentle activities like walking, yoga, or light stretching during recovery. High-intensity exercise, long-duration cardio, and excessive strength training all suppress the reproductive axis regardless of supplement use. Once periods return and stabilize for several months, you can gradually reintroduce more intensive exercise while monitoring your cycles.
What’s the most important supplement for amenorrhea recovery?
It depends on the cause. For all types of amenorrhea, calcium and vitamin D are essential for bone protection—this is non-negotiable. For PCOS amenorrhea, inositol (40:1 ratio) has the strongest evidence for restoring ovulation. For hypothalamic amenorrhea, no supplement replaces adequate food and rest, though magnesium, iron, and vitamin D may support recovery. For elevated prolactin amenorrhea, vitex may help. The “most important” supplement varies by individual diagnosis.
Should I keep taking supplements after my period returns?
Continue calcium and vitamin D until you’ve had regular periods for at least 6-12 months to protect bone density. For PCOS, many women benefit from continuing inositol long-term to maintain cycle regularity and metabolic health. For FHA recovery, you may be able to discontinue most supplements once you’ve maintained regular cycles for 6+ months while keeping adequate food intake and reasonable exercise. Always work with your healthcare provider to determine when it’s appropriate to discontinue supplements.
Can stress prevent supplements from working for amenorrhea?
Yes, particularly for hypothalamic amenorrhea. Chronic high stress elevates cortisol and suppresses the hypothalamic-pituitary-ovarian axis regardless of supplement use. This is why stress management (therapy, meditation, adequate sleep, reduced life stress) is as important as nutritional interventions for FHA. Supplements like ashwagandha or magnesium can help with stress management, but they cannot override the effects of severe ongoing stress. Addressing the stress itself—through therapy, life changes, or other interventions—is essential.
