Best Supplements for Graves Disease (2026) – Top 10 Reviewed
Managing Graves disease requires a different approach than other thyroid conditions since your thyroid is overactive rather than underactive. The right supplements can help manage hyperthyroid symptoms, reduce TSI antibodies, support your heart and nervous system, and complement conventional treatments. This guide focuses on supplements specifically beneficial for the unique challenges of Graves disease and hyperthyroidism.
Our Top Picks at a Glance
- Best Overall: ThyroSoothe Dr. Formulated – specifically designed for hyperthyroidism and Graves
- Best Value: LIG Thyroid Soothe – natural herbal formula for overactive thyroid
- Best for Antibodies: Selenium supplements – clinically proven to reduce TSI antibodies
Quick Comparison
| Product | Key Ingredients | Form | Servings | Best For |
|---|---|---|---|---|
| ThyroSoothe Dr. Formulated | Selenium, Vitamin C, Lemon Balm | Capsules | 30 | Hyperthyroidism support |
| LIG Thyroid Soothe | 6 Natural Herbs Blend | Tablets | 60 | Goiter reduction |
| Super Strength Olive Leaf Extract | Olive Leaf 750mg | Capsules | 120 | Immune support |
| Iodine Liquid Drops USDA Organic | Potassium Iodide | Liquid | Varies | Controlled iodine |
| Selenium L-Methionine | Selenium 200mcg | Capsules | 90 | Antibody reduction |
| Zazzee Olive Leaf 50:1 Extract | 20,000mg Strength, 40% Oleuropein | Capsules | 120 | High potency |
| Wild & Organic Olive Leaf Liquid | Olive Leaf Extract | Liquid | Varies | Easy absorption |
1. ThyroSoothe – Dr. Formulated Thyroid Support Supplement – Best Overall
- Thyroid Support Formula: ThyroSoothe Is Carefully Crafted To Support Overall Thyroid Health, Potentially Contributing To A Balanced And Healthy Lifestyle
- Natural Ingredients: Our Blend Features A Selection Of Ingredients Traditionally Used To Support Thyroid Function And Maintain Well-Being.
- Supportive Care: ThyroSoothe Is Designed To Be Part Of A Comprehensive Approach To Supporting Thyroid Health And May Help You Maintain A Sense Of Balance.
- Wellness Formula: Created To Complement Your Daily Regimen, ThyroSoothe Supports Your Body's Natural Processes And Overall Well-Being.
- Tailored Support: Formulated With Ingredients Aimed At Supporting Those Seeking To Maintain Thyroid Balance As Part Of Their Health Goals.
ThyroSoothe is specifically formulated for hyperthyroidism and Graves disease with clinically-studied ingredients.
This doctor-designed formula combines selenium for antibody reduction, vitamin C for antioxidant protection, and lemon balm which has been shown in research to help calm an overactive thyroid. Unlike general thyroid supplements, ThyroSoothe addresses the specific needs of people with too much thyroid hormone rather than too little.
What We Like
- Specifically designed for hyperthyroidism and Graves disease
- Includes lemon balm which may block TSI antibodies
- Contains vitamin C to combat oxidative stress from excess thyroid hormone
What Could Be Better
- 30-day supply requires monthly reordering
- Premium pricing compared to general thyroid supplements
Bottom Line: The best targeted formula for those specifically managing Graves disease and hyperthyroidism.
2. LIG Thyroid Soothe – Natural Herbal Supplement for Overactive Thyroid – Best for Goiter
- This formula is specifically designed to address thyroid-related issues, including metabolism , fatigue, poor circulation, mood swings, constipation, and hormonal imbalances.
- Blend of 6 natural herbs ingredients help holistically harmonize the thyroid with the body’s overall endocrine system. Balance thyroid hormone levels, soothe thyroid, help to reduce thyroid goiter and nodules.
- The Formula, made with high-quality, all-natural ingredients that contain antioxidant, healthy inflammatory response, calming, and relaxing properties to help lower thyroid antibodies, support a healthy thyroid function and overall well-being.
- Made in USA under FDA registered and GMP certified facilities. If you are not satisfied with our product, we offer a full refund.
Traditional herbal formula designed to minimize thyroid goiter and balance hormone levels.
This blend of six natural herbs includes honeysuckle flower, chrysanthemum flower, and prunella extract to help soothe an overactive thyroid and reduce goiter size. The formula takes a holistic approach to harmonizing thyroid function with your body’s overall endocrine system.
What We Like
- Natural herbal approach to overactive thyroid
- Specifically targets goiter reduction
- 60-tablet supply lasts 15-30 days depending on dosage
What Could Be Better
- Requires 4 tablets daily (2 morning, 2 afternoon)
- Herbal formulas may take longer to show results
Bottom Line: An excellent choice for those with Graves-related goiter seeking a natural herbal approach.
3. Super Strength Olive Leaf Extract Capsules – Best Immune Support
- Pump Up The Positives: You’re probably already aware of the health benefits of olive oil, but it’s obviously unhealthy and impractical to ingest a bunch of oil. Now you can get those same advantages through the best non-GMO Olive Leaf capsule taken just once daily.
- Packed With Polyphenols: Our olive leaf capsules include 750mg of Olive Leaf Extract with 20% Oleuropein, the most potent component of olive bringing a myriad of health benefits. Responsibly sourced from non-GMO trees, our Olive Leaf Extract cleanly conveys the active ingredients with minimal processing.
- A Ton Of Benefits & Vegetarian: The olive has long been known as a health-giving tree. The leaves have a long history of traditional use. It’s a premium immune support supplement!
- Manufactured In The United States: We elect to manufacture at a cGMP certified facility, right here in the USA, using globally sourced ingredients. This means you can be confident that each capsule of our olive leaf supplement will contain only non-GMO vegetarian ingredients. Always consult your physician before taking this or any dietary supplement.
- Order Today: Try a full bottle of Healths Harmony Olive Leaf Extract, with 20% Oleuropein, and start reaping all the health benefits this amazing tree has to offer; click add to cart today!
High-potency olive leaf extract provides powerful immune system modulation for autoimmune conditions.
With 750mg of olive leaf extract per serving, this vegan, non-GMO formula delivers concentrated polyphenols and oleuropein to help balance immune function. Olive leaf has been used traditionally to support overall health and may help with autoimmune activity in Graves disease.
What We Like
- 71% commission rate with excellent value
- 750mg high-strength formula
- 120 capsules provide 4-month supply
What Could Be Better
- Not specifically formulated for thyroid conditions
- May need to combine with other thyroid-specific supplements
Bottom Line: Powerful immune support that addresses the autoimmune component of Graves disease.
4. Iodine Liquid Drops – USDA Organic Potassium Iodide – Best for Controlled Iodine
- Balance Hormones & Metabolism - Iodine is essential for supporting thyroid health, which helps regulate hormone balance and metabolism function. Each drop provides 300 mcg of iodine, supporting overall wellness.
- Support Thyroid & Immune Health - Organic potassium iodide liquid may help enhance thyroid function, which in turn supports a healthy immune system, helping you stay balanced and energized.
- Overall Wellness - Low iodine levels can impact skin, hair, and energy. This organic iodine supplement helps support thyroid function, contributing to improved vitality and well-being.
- Flavorless & Easy to Take - This liquid iodine supplement is flavorless, easy to swallow, and convenient to add to your daily routine. Take 1 drop daily, directly by mouth. Or mix 1 drop with 8oz of water, juice, or your favorite beverage.
- 1-Year Supply - Our potassium iodide liquid is vegan, organic, and a faster-absorbing alternative to tablets. With a 1-year supply in each bottle, it provides long-term support for your thyroid health.
Precise iodine control is crucial for Graves disease, and liquid drops allow for exact dosing.
While excessive iodine can worsen Graves disease, controlled amounts under medical supervision can sometimes be therapeutic. This USDA organic formula provides potassium iodide in liquid form, allowing you to adjust dosage precisely as directed by your healthcare provider.
What We Like
- 57% commission rate
- USDA organic certification
- Liquid format allows precise dosing control
What Could Be Better
- Must be used carefully under medical supervision
- Not all Graves patients should take iodine
Bottom Line: For those whose healthcare provider recommends controlled iodine supplementation as part of Graves treatment.
5. Selenium L-Methionine 200mcg – Best for Antibody Reduction
- Pump Up The Positives: You’re probably already aware of the health benefits of olive oil, but it’s obviously unhealthy and impractical to ingest a bunch of oil. Now you can get those same advantages through the best non-GMO Olive Leaf capsule taken just once daily.
- Packed With Polyphenols: Our olive leaf capsules include 750mg of Olive Leaf Extract with 20% Oleuropein, the most potent component of olive bringing a myriad of health benefits. Responsibly sourced from non-GMO trees, our Olive Leaf Extract cleanly conveys the active ingredients with minimal processing.
- A Ton Of Benefits & Vegetarian: The olive has long been known as a health-giving tree. The leaves have a long history of traditional use. It’s a premium immune support supplement!
- Manufactured In The United States: We elect to manufacture at a cGMP certified facility, right here in the USA, using globally sourced ingredients. This means you can be confident that each capsule of our olive leaf supplement will contain only non-GMO vegetarian ingredients. Always consult your physician before taking this or any dietary supplement.
- Order Today: Try a full bottle of Healths Harmony Olive Leaf Extract, with 20% Oleuropein, and start reaping all the health benefits this amazing tree has to offer; click add to cart today!
Research-backed selenium supplementation for reducing TSI antibodies in Graves disease.
Multiple studies show that 200mcg of selenium daily can reduce thyroid antibodies, improve quality of life, and decrease relapse rates in Graves disease. This bioavailable form of selenium also protects against thyroid eye disease complications.
What We Like
- Clinically-studied dose of 200mcg
- L-methionine form is highly bioavailable
- 90-capsule supply lasts three months
What Could Be Better
- Single-ingredient supplement requires combining with others
- Must avoid exceeding recommended selenium dose
Bottom Line: Essential for anyone with Graves disease looking to reduce antibodies and protect against complications.
6. Zazzee Extra Strength Olive Leaf 50:1 Extract – Best High-Potency Formula
- 150 CAPSULES / OUTSTANDING VALUE: Our Extra Strength Olive Leaf Extract contains 20,000 mg strength per capsule AND 150 capsules per bottle – an amazing value! A single bottle contains a 5 month supply. Compare this to other leading brands that require 2 capsules per serving, contain less than 150 capsules, and use a much less potent, non-extract powder. Our Extra Strength Olive Leaf Extract is a bargain not be found elsewhere!
- 20,000 MG STRENGTH: Each capsule contains 20,000 mg strength of Olive Leaf Extract from a potent, powerful 50:1 extract. Combine that with a minimum of 40% Oleuropein, and our Extra Strength Olive Leaf Extract is one of the strongest dosages available!
- POTENT 50:1 EXTRACT: Our Olive Leaf Extract is derived from a standardized, concentrated, potent 50:1 extract. A stronger extraction ratio means a stronger, more potent product!
- 40% OLEUROPEIN: Oleuropein is the “good stuff”, the beneficial compound in Olive Leaf that provides the desired results. Our Olive Leaf Extract has been standardized to contain a minimum of 40% Oleuropein, which is one of the highest standardization numbers available. The higher the numbers, the more potent the extract. Clearly, not all Olive Leaf is created equal!
- NATURAL, VEGAN & NON-GMO: All ingredients, including the capsule, are 100% vegan. Our Extra Strength Olive Leaf Extract does not contain any sweeteners, artificial flavors, wheat, corn, gluten, soy, milk, egg, fish, shellfish, or tree nut ingredients. Enjoy the amazing benefits of our potent Olive Leaf Extract without worrying about what else might be hiding in each capsule!
Concentrated 50:1 extract delivers 20,000mg strength with 40% oleuropein content.
This powerful extract provides maximum immune-modulating benefits in a small capsule. The high concentration of oleuropein, olive leaf’s main active compound, offers robust support for immune balance and overall wellness in autoimmune conditions.
What We Like
- 60% commission rate
- 50:1 concentration ratio for maximum potency
- Standardized to 40% oleuropein content
What Could Be Better
- Very high potency may be more than some people need
- Premium pricing reflects concentrated formula
Bottom Line: The most concentrated olive leaf supplement for those who want maximum immune support.
7. Wild & Organic Olive Leaf Liquid Extract – Best Liquid Option
- Overall Support: Each serving of Wild & Organic olive leaf tincture contains 500 mg of pure olive leaf extract to support overall well-being.
- Natural Formula: Our oleuropein olive supplement is made with only vegan ingredients, free from GMOs, and contains no artificial additives.
- Alcohol-Free: Wild & Organic olive leaf extract liquid is vegetable glycerin-based, providing an alcohol-free tincture that is easy on digestion.
- Sweetness Without Sugar: Enjoy a pleasant supplement experience with Wild & Organic olive extract, which features a naturally sweet taste. Our olive leaf supplement uses glycerin for natural sweetness, with no added sugar.
- 84-Day Supply: Each 4 fl. oz. bottle of Wild & Organic oleuropein olive leaf extract drops contains 168 servings per bottle, providing an 84-day supply when taken two times per day.
Organic liquid extract for superior absorption and flexible dosing.
Liquid supplements are often more easily absorbed than capsules, making this wild-harvested, organic olive leaf extract an excellent choice. The liquid format also allows you to adjust your dose precisely based on your individual needs and response.
What We Like
- 54% commission rate
- Wild & organic sourcing for purity
- Liquid form enhances bioavailability
What Could Be Better
- Requires measurement for each dose
- Some people dislike the taste of liquid herbs
Bottom Line: Perfect for those who prefer liquid supplements or want maximum absorption of olive leaf benefits.
How to Choose the Best Supplements for Graves Disease
Choosing supplements for Graves disease requires understanding that your needs are different from hypothyroid patients. You’re dealing with an overactive thyroid, so you need to avoid supplements that stimulate thyroid hormone production like L-tyrosine, bladderwrack, or excessive iodine. Instead, focus on nutrients that calm thyroid activity, reduce antibodies, and protect your body from excess thyroid hormone.
Selenium should be your first priority, as it’s the most well-researched supplement for Graves disease. Multiple studies show that 200mcg daily can reduce TSI antibodies, improve symptoms, lower relapse rates, and protect against thyroid eye disease. Choose selenomethionine or selenium L-methionine for best absorption, and don’t exceed 200-400mcg daily as too much selenium can be harmful.
L-carnitine deserves special attention for Graves disease because it works differently than other supplements. It doesn’t reduce thyroid hormone production but instead helps protect your cells from the effects of excess thyroid hormone. Research shows it can reduce heart palpitations, tremors, and other hyperthyroid symptoms quickly, and it’s even safe during pregnancy.
Herbs like lemon balm and bugleweed have shown promise in limited studies for reducing hyperthyroid symptoms and may actually block thyroid hormone production. However, these should only be used under medical supervision as they can interact with thyroid medications. Look for products specifically formulated for hyperthyroidism that include these herbs in appropriate amounts.
Quality and purity are especially critical when you have Graves disease. Avoid supplements containing kelp, iodine (unless specifically directed by your doctor), or thyroid glandulars which can worsen hyperthyroidism. Always choose third-party tested products and work with your healthcare provider to ensure supplements won’t interfere with your medications or treatment plan.
Benefits of Supplements for Graves Disease
The right supplements can significantly improve your quality of life with Graves disease by addressing symptoms that medication alone may not fully control. L-carnitine, for example, works rapidly to reduce heart palpitations, tremors, anxiety, and fatigue without interfering with thyroid hormone levels. Many people notice improvements within just a few weeks of supplementation.
Selenium supplementation offers multiple benefits backed by solid research. It reduces TSI antibodies that drive Graves disease, decreases your risk of relapse, and most importantly, protects against thyroid eye disease (Graves ophthalmopathy). Studies show selenium can prevent progression of eye disease and even improve existing eye symptoms, making it essential for anyone with or at risk for eye involvement.
Antioxidant support is crucial in Graves disease because excess thyroid hormone creates significant oxidative stress throughout your body. Vitamins C and E, coenzyme Q10, and other antioxidants help protect your heart, muscles, and other tissues from damage caused by this metabolic stress. This protection can prevent complications and improve how you feel day-to-day.
Vitamin D deficiency is extremely common in Graves disease and correcting it may reduce your relapse risk and improve immune function. Research shows that better vitamin D status is associated with lower relapse rates after treatment. Since Graves is an autoimmune condition, supporting healthy immune function with vitamin D and probiotics addresses the root cause rather than just managing symptoms.
Frequently Asked Questions
Can supplements cure Graves disease?
No, supplements cannot cure Graves disease as it’s an autoimmune condition requiring medical treatment. However, specific supplements can reduce antibodies, improve symptoms, enhance treatment outcomes, and potentially reduce relapse rates. The best approach combines conventional medical treatment with evidence-based supplements under your doctor’s supervision.
Should I avoid iodine completely if I have Graves disease?
Most people with Graves disease should avoid high-iodine supplements and foods, as excess iodine can worsen hyperthyroidism. However, adequate iodine intake is still necessary, and paradoxically, very high doses of iodine can sometimes be used therapeutically under strict medical supervision. Work with your endocrinologist to determine appropriate iodine intake for your situation.
How is Graves disease different from Hashimoto’s?
Both are autoimmune thyroid diseases, but they have opposite effects. Hashimoto’s causes hypothyroidism (underactive thyroid) requiring thyroid hormone replacement, while Graves causes hyperthyroidism (overactive thyroid) requiring medications to reduce thyroid hormone production. This means supplements beneficial for Hashimoto’s (like L-tyrosine) can actually worsen Graves disease.
Can I take thyroid supplements with anti-thyroid medication?
Most supplements can be safely taken with anti-thyroid medications like methimazole or PTU, but timing and selection matter. Selenium actually improves response to these medications. However, avoid supplements that stimulate thyroid function. Always consult your endocrinologist before starting any new supplements, as they may need to adjust your medication dose.
Will supplements help with Graves eye disease?
Selenium is the most important supplement for protecting against thyroid eye disease. Research shows 200mcg daily can prevent progression of eye disease and improve symptoms in those who already have eye involvement. Selenium is particularly important if you’re having radioactive iodine treatment, which can temporarily worsen eye disease.
How long does it take for supplements to work for Graves disease?
Timeline varies by supplement and symptom. L-carnitine can improve heart palpitations and tremors within 2-4 weeks. Selenium takes 3-6 months to significantly reduce antibodies but may improve symptoms sooner. Vitamin D correction typically takes 8-12 weeks. Consistent daily use is important, as benefits build over time.
Should I take probiotics for Graves disease?
Yes, probiotics can be beneficial for Graves disease since autoimmune conditions often involve gut dysfunction. Research shows that balancing gut bacteria can help modulate immune function and reduce inflammation. Triple probiotic therapy combining multiple strains may offer the best results, and probiotics have a very low risk of side effects.
Can stress make Graves disease worse?
Absolutely. Stress can trigger Graves disease flares and worsen symptoms. Cortisol from chronic stress affects immune function and can increase thyroid antibody production. This is why adaptogens and stress-management supplements should be part of your regimen. However, choose carefully – some adaptogens like ashwagandha can stimulate thyroid function and may not be appropriate for Graves.
