Best Supplements for Grief and Loss (2026) – Top 10 Reviewed
Grief is a deeply personal journey that affects both your emotional and physical well-being. While there’s no supplement that can eliminate the pain of loss, certain nutrients and herbs can help support your body during this difficult time by promoting emotional balance, reducing stress, and supporting healthy sleep patterns. This guide reviews the best supplements that may help you navigate grief with greater resilience.
Our Top Picks at a Glance
- Best Overall: Relaxium Calm – comprehensive mood and stress support formula
- Best Value: WellPath Zen – combines ashwagandha and rhodiola for resilience
- Best Premium: Neurobiologix Mood Plus – professional-grade emotional wellness support
Quick Comparison
| Product | Key Ingredients | Form | Servings | Best For |
|---|---|---|---|---|
| Relaxium Calm | Ashwagandha, 5-HTP, GABA | Capsules | 60 | Overall emotional support |
| WellPath Zen | Ashwagandha, Rhodiola, L-Theanine | Capsules | 60 | Stress resilience |
| Neurobiologix Mood Plus | GABA, 5-HTP, Magnesium | Capsules | 60 | Professional-grade support |
| 10-in-1 Cortisol Detox | Ashwagandha, Magnesium, L-Theanine | Capsules | 60 | Cortisol management |
| SAM-e 1500mg | S-Adenosyl Methionine | Capsules | 60 | Mood elevation |
| aSquared Rhodiola | Rhodiola Rosea 1000mg | Capsules | 180 | Stress adaptation |
| Evlution Magnesium + L-Theanine | Magnesium, L-Theanine | Capsules | 60 | Calm and focus |
1. Relaxium Calm – Best Overall
- STRESS & MOOD STABILIZER: Relaxium Calm, made with Ashwagandha, uses a whole-body solution to help manage stress and promote relaxation by supplying essential vitamins for mood support and stress relief.
- SAFE, POTENT & NON-HABIT FORMING: Doctor formulated, this calming supplement is non-habit forming, easy-to-swallow, and side-effect free. Relaxium Calm is your effective and gentle answer to relieving stress, worry and improving your mood.
- HIGH QUALITY & PURE INGREDIENTS: Relaxium Calm is produced by one of the most pristine and experienced dietary supplement manufacturers. Cruelty Free.
- MADE IN THE USA: Made at an FDA-inspected facility for quality you can trust, Relaxium Calm provides the perfect synergistic blend of ingredients for reliable potency and effectiveness. Our facilities use state of the art technology and adheres to strict FDA manufacturing practices.
- 100% MONEY-BACK: We created a calm supplement that fits your life. Your satisfaction is our top priority; if we don't meet your expectations just send your stress relief supplement back for a 30-day full refund.
Relaxium Calm stands out as a comprehensive formula designed to support emotional balance during difficult times.
This supplement combines ashwagandha, 5-HTP, and GABA to help regulate stress hormones, support serotonin production, and promote a sense of calm. The non-habit forming formula also includes immune support ingredients, which can be particularly helpful since grief often impacts physical health.
What We Like
- Multi-targeted approach addresses both mood and stress
- Includes 5-HTP to support serotonin levels naturally
- Non-habit forming with immune support benefits
What Could Be Better
- May take several weeks to notice full effects
- Contains multiple ingredients that some may prefer individually
Bottom Line: An excellent comprehensive choice for those seeking multi-faceted support during grief with both emotional and immune benefits.
2. WellPath Zen – Best Value
- [Stress Relief Formula] Do you get overwhelmed by daily stressors? We know the feeling! Which is why we created Zen. It's expertly curated with herbs, vitamins, and adaptogens to support your daily stressors and help you live in a zen state of mind!
- [Stay Focused and Calm] You deserve to live a happy, healthy life. That's why we combine superfoods like Passionflower & Niacinamide powder with Riboflavin and magnesium in our products so you can be more positive throughout your day!
- [Vitamins for Men and Women] Zen's vitamin supplement is a vegan daily multivitamin for women and men who want to help improve their mood. We use naturally sourced herbal ingredients to help cultivate a positive sense of well-being.
- [Premium Herbal Ingredients] WellPath Zen's calming vitamin features Ashwagandha, an Ayurvedic herb known to assist with balancing occasional stress; Rhodiola Rosea, L-Theanine, Hawthorn Leaf, Lemon Balm & more! Designed for your daily stress support
- [Featuring Ashwagandha + Rhodiola Rosea] Ashwagandha & Rhodiola Rosea are adaptogenic herbs known for their ability to help the body adapt to stress & improve energy levels.
WellPath Zen delivers powerful stress relief and mood support through adaptogenic herbs at an accessible price point.
This formula features ashwagandha and rhodiola, two well-researched adaptogens that help your body manage stress more effectively. The addition of L-theanine provides calm focus without drowsiness, making it suitable for daytime use during grief.
What We Like
- Combines proven adaptogens for resilience building
- L-theanine provides calm without sedation
- Excellent value for high-quality ingredients
What Could Be Better
- Effects build gradually over time
- May need to take consistently for best results
Bottom Line: A solid value option that uses adaptogenic herbs to help build emotional resilience during the grieving process.
3. Neurobiologix Mood Plus – Best Premium
- Balanced Mood & Stress Support: Mood Plus combines adaptogens and amino acids to help support neurotransmitter activity for a calm, steady mood and healthy stress response—without caffeine or stimulants.
- Promotes Emotional Wellness: Adaptogenic herbs and amino acids work together to encourage emotional balance, healthy serotonin levels, and mental clarity throughout the day.
- Formulated With Key Nutrients: Features GABA, 5-HTP, Ashwagandha, Magnesium, Niacin, and Chamomile to support relaxation, emotional balance, and neurotransmitter activity for a calm, focused mood.
- How To Use: Adults take 1 capsule twice daily or as directed by a healthcare professional. Use daily to help support emotional stability and overall well-being.
- Clean, Professional-Grade Ingredients: Gluten free, dairy free, soy free, and non GMO. Made in the USA in a cGMP-certified facility for purity, safety, and potency — with no artificial colors, preservatives, or additives.
Neurobiologix offers professional-grade mood support with carefully selected nutrients for emotional wellness.
This premium formula includes GABA for calm, 5-HTP for serotonin support, magnesium for stress management, and chamomile for gentle relaxation. It’s designed to promote emotional balance and mental clarity throughout the day.
What We Like
- Professional-grade formulation with clean ingredients
- Gluten-free, dairy-free, and non-GMO
- Made in USA in cGMP-certified facility
What Could Be Better
- Higher price point than some alternatives
- Requires twice-daily dosing
Bottom Line: A premium choice for those who want professional-grade emotional support with transparent, clean ingredients.
4. 10-in-1 Cortisol Detox
- Targeted Cortisol Management - Clinically formulated to help manage cortisol levels in the body, supporting a balanced cortisol response during pressure; Our cortisol detox adaptogenic blend (ashwagandha, chamomile, phosphatidylserine) works synergistically to regulate cortisol production—These cortisol supplements for women/men ideal for busy professionals, parents, or anyone seeking adrenal support without fillers or additives
- Pressure Management & Relaxation - Are you still struggling with office pressure? Our cortisol reducer supplements blend tension-fighting ingredients like magnesium glycinate (122mg) and L-theanine (50mg) to promote relaxation while maintaining mental clarity; The addition of vitamin C (90mg) and D3 (20mcg) supports overall wellness, helping you cope with pressure naturally
- Science-Backed Formulation - Every capsule delivers precise dosages: 250mg ashwagandha extract (20:1), 50mg chamomile (10:1), and 24mg phosphatidylserine for optimal effectiveness; Unlike generic lower cortisol for women, these cortisol supplement use no synthetic fillers—just a clean, vegan-friendly formula trusted by health-conscious users
- Dual-Action Cortisol Balance for All Lifestyles - Whether you’re a fitness enthusiast, a night-shift worker, or juggling daily demands, our cortisol reducer adapts to your needs; St. John’s wort (20mg) and astragalus (20mg) support mood stability*, while black pepper extract (10:1) ensures maximum nutrient absorption; Take 2 capsules daily—morning and evening—for sustained cortisol support
- 60-Day Supply - We stand behind our cortisol supplement for men and women with rigorous quality testing; Our formula is non-GMO, allergen-free, and manufactured in a cGMP facility; Join thousands who’ve transformed their tension management—try CortiCare risk-free and experience why we’re ranked among the best supplements to lower cortisol!
This comprehensive formula targets stress hormones that often become elevated during grief.
The 10-in-1 blend includes ashwagandha to regulate cortisol, magnesium for nervous system support, and L-theanine for calm focus. This combination helps address the physical stress response that accompanies emotional grief.
What We Like
- Specifically targets cortisol management
- Combines 10 synergistic ingredients
- Suitable for both women and men
What Could Be Better
- Complex formula may not suit those preferring simplicity
- Takes time to regulate cortisol levels
Bottom Line: An excellent choice for addressing the stress hormone imbalances that often accompany grief and loss.
5. SAM-e 1500mg High Strength
- The Healthy Way: Live your life the Healthy Way with the help of our SAMe supplement renowned for its mind and brain support properties to help promote cognitive wellness
- Support Starts Here: No matter your health journey we are here to lend a helping hand with potent nutritional supplements guided by our commitment to utilizing tried and true ingredients
- Tangible Benefits: SAM-e (s-adenosylmethionine) is a naturally occurring compound in the body that decreases over time but is needed for many crucial functions to ensuring optimal health
- American Made: Our SAM-E supplement is proudly made in the US in a cGMP facility to give you the confidence that your health in good hands
- Made Clean: This premium formula contains no Artificial flavors and colors, preservatives, dairy, salt, sodium or gluten
SAM-e is a naturally occurring compound that supports mood through multiple pathways.
S-Adenosyl-L-Methionine helps with neurotransmitter production and has been studied for its mood-elevating properties. This high-strength formula provides 1500mg per serving for those needing robust support.
What We Like
- High potency for significant mood support
- Well-researched for mood elevation
- Also supports joint health
What Could Be Better
- Can take 2-4 weeks to notice effects
- Best taken on empty stomach
Bottom Line: A powerful single-ingredient option for those seeking significant mood support during difficult times.
6. aSquared Rhodiola Rosea 1000mg
- MAXIMUM STRENGTH RHODIOLA ROSEA: Our potent Rhodiola Rosea formula contains 500mg per veggie capsule (1000mg per serving), and is made in the USA in a GMP compliant facility. Rhodiola Rosea is known as an Adaptogen, helping the body adapt to stress. The Rhodiola plant is native to the arctic regions of Asia, Europe and even Siberia. Don't settle for 60, 90 or 120 capsules. We offer 180 vegan capsules per bottle. *
- HELPS BOOST ENERGY, MOOD & PERFORMANCE: Rhodiola Rosea helps boost energy levels, supports normal and elevated mood, and may even increase physical and athletic performance. Additionally, Rhodiola Rosea promotes healthy immune system and thyroid function. Similar to Panax Ginseng and Ashwagandha, Rhodiola is an adaptogen and is often used to help the mind and body adapt to stress. *
- HELPS BOOST MEMORY & BRAIN FUNCTION: Rhodiola Rosea promotes healthy brain function, supports increased memory. Rhodiola Rosea may improve the absorbency of the blood-brain barrier supporting normal transport of the neurotransmitters serotonin and dopamine that are essential for promoting healthy mood. Additionally, Rhodiola has antioxidant properties. *
- BEST VALUE AVAILABLE ON AMAZON: Our high potency Rhodiola Rosea complex comes with 180 veggie capsules, each containing 500 mg of Rhodiola – not to be confused with the forms of Rhodiola such as Drops, Oil, Liquid, Drink, Cream, Caps, Chewable, and Tea – and contains a high dosage of Rosavin and Salidrosid.. Rhodiola Rosea is also called Arctic Root, Goldenroot, Rose Root Extract, Rosenroot, Sedum Rhodiola, Roseroot, Siberian Golden Root and more. *
- PROVEN TRACK RECORD: aSquared Nutrition takes pride in quality and reliability. You’ll love our ever-expanding product line from CoQ10 400mg (Coenzyme Q10) to Vitamin B-12 (Methyl B12). Other products include Panax Ginseng, Milk Thistle 1000 MG, DHEA 100mg, Resveratrol 1000mg, Turmeric Curcumin, Natural Ceylon Cinnamon (100% All Natural), Green Coffee Bean Extract, Garcinia Cambogia, Berberine, and Forskolin 500mg. *
Rhodiola is a powerful adaptogen that helps build resilience to emotional and physical stress.
This max-strength formula provides 1000mg of rhodiola root extract in vegan capsules. Rhodiola has been traditionally used to combat fatigue and support mental clarity during stressful periods, making it valuable during grief.
What We Like
- Maximum strength rhodiola for stress adaptation
- 180 capsules provide excellent value
- Vegan-friendly formula
What Could Be Better
- Single ingredient may need complementing
- Can be mildly energizing for some
Bottom Line: An excellent adaptogen for building long-term stress resilience during the grieving process.
7. Evlution Nutrition Magnesium + L-Theanine
- Science Based Formula - Try the EVL Magnesium + L-Theanine dietary supplement that is formulated to ensure every capsule encapsulates the essence of relaxation, restoration and focus support. This supplement is a great addition to your daily routine.
- Magnesium + L-Theanine - EVL’s Magnesium + L-Theanine formula combines Magnesium and L-Theanine to offer a convenient yet effective dietary supplement. These veggie capsules are designed to help support overall relaxation and focus in your daily life.
- Veggie Capsules - Our Magnesium + L-Theanine dietary supplement contains 200mg of Magnesium and 100mg of L-Theanine per serving. This magnesium and l-theanine supplement for men and women comes in convenient veggie capsules.
- Quality Ingredients - We’re proud to use some of the finest ingredients for peak performance. Our Magnesium + L-Theanine supplement is vegan, non-GMO and free of unnecessary additives. As a dietary supplement, take 2 veggie capsules daily, preferably with a meal or as recommended by a physician.
- Why EVL - EVL is a leading name in full stack supplements because we take our quality seriously and only use the finest lab tested performance maximizing ingredients.
This simple yet effective combination promotes natural relaxation and mental focus.
Magnesium supports nervous system function and muscle relaxation, while L-theanine promotes calm alertness. Together, they create a sense of relaxed focus that can be helpful when grief makes concentration difficult.
What We Like
- Clean two-ingredient formula
- Supports both relaxation and focus
- From trusted sports nutrition brand
What Could Be Better
- Simpler formula than comprehensive blends
- May need additional support for mood
Bottom Line: A straightforward option for those seeking calm focus and nervous system support during grief.
How to Choose the Best Supplement for Grief and Loss
When selecting a supplement to support you through grief, consider your primary symptoms. If you’re experiencing difficulty sleeping, look for formulas with calming ingredients like magnesium, L-theanine, or chamomile. For low mood and emotional heaviness, supplements containing 5-HTP or SAM-e may be more appropriate as they support serotonin production.
Adaptogenic herbs like ashwagandha and rhodiola are excellent for building long-term stress resilience. These work by helping your body adapt to stress more effectively over time. They’re particularly valuable if your grief is accompanied by physical exhaustion or feeling overwhelmed by daily responsibilities.
Consider whether you prefer comprehensive formulas that address multiple aspects of stress and mood, or single-ingredient supplements that you can customize. Some people find that starting with a well-rounded formula provides broader support, while others prefer to target specific symptoms with individual nutrients.
Quality matters significantly when choosing supplements during this vulnerable time. Look for products that are third-party tested, made in certified facilities, and free from unnecessary fillers. Starting with lower doses and gradually increasing can help you assess how your body responds.
Remember that supplements work best as part of a holistic approach to grief that includes proper sleep, nutrition, gentle movement, and connection with supportive people. They’re tools to support your healing, not replacements for processing your emotions or seeking professional help when needed.
Benefits of Supplements During Grief and Loss
Grief affects your body in profound ways that extend beyond emotional pain. Stress hormones like cortisol can remain elevated for extended periods, affecting sleep quality, immune function, and overall energy levels. Supplements that support healthy cortisol regulation can help your body maintain better balance during this challenging time.
Many people experiencing grief report difficulty with sleep – either falling asleep, staying asleep, or experiencing restful sleep. Magnesium supports the nervous system’s ability to relax, while L-theanine promotes alpha brain waves associated with calm alertness. These nutrients can help your body transition more easily into rest without causing morning grogginess.
Neurotransmitter support is another key benefit. Grief can deplete brain chemicals like serotonin and dopamine that regulate mood and motivation. Supplements containing 5-HTP provide the building blocks for serotonin production, while adaptogens help regulate the broader stress response system. This support can make daily functioning feel more manageable.
The immune system often takes a hit during grief, making you more susceptible to illness at an already difficult time. Some grief-support supplements include immune-supporting ingredients alongside mood nutrients, providing comprehensive care for your whole system as it processes loss.
Frequently Asked Questions
How long does it take for grief support supplements to work?
The timeline varies depending on the ingredient. L-theanine and magnesium can provide calming effects within hours, while adaptogens like ashwagandha and rhodiola typically require 2-4 weeks of consistent use to build stress resilience. SAM-e and 5-HTP generally need 2-4 weeks to noticeably impact mood. Be patient and consistent with your chosen supplement, as many work by supporting your body’s natural processes rather than providing immediate symptom relief.
Can I take these supplements with antidepressants?
Some grief support supplements, particularly those containing 5-HTP or SAM-e, can interact with antidepressant medications. Always consult your healthcare provider before combining supplements with prescription medications. They can help you create a safe, comprehensive plan that addresses your needs without unwanted interactions.
Are there any side effects I should watch for?
Most grief support supplements are well-tolerated, but some people may experience mild digestive upset when starting new supplements. Adaptogens can occasionally cause headaches during the first few days as your body adjusts. If you experience any concerning symptoms, reduce your dose or discontinue use and consult a healthcare provider.
Should I take supplements in the morning or evening?
This depends on the ingredients. Adaptogens like rhodiola and ashwagandha are often best taken in the morning or early afternoon, as they can be mildly energizing for some people. Calming supplements with magnesium or L-theanine can be taken in the evening to support relaxation and sleep. Follow the specific recommendations on your chosen product.
How long should I continue taking grief support supplements?
There’s no set timeline, as grief is a highly individual process. Many people find supplements helpful for several months as they work through acute grief. You might gradually reduce your dosage as you feel more stable, or continue with lower maintenance doses long-term. Listen to your body and adjust as your needs change.
Can supplements replace therapy or counseling for grief?
No, supplements should complement but not replace professional grief support. While they can help manage physical symptoms of stress and support your body’s resilience, processing grief typically requires the kind of emotional work that happens through therapy, support groups, or trusted relationships. Consider supplements as one tool in a comprehensive approach to healing.
Are natural supplements safer than prescription medications for grief?
Natural doesn’t automatically mean safer – both supplements and medications have their place. Supplements generally have fewer side effects than prescription medications, but they can still interact with medications and aren’t appropriate for everyone. The right choice depends on the severity of your symptoms, your overall health, and your preferences. Work with a healthcare provider to determine the best approach for you.
What else can I do alongside supplements to support healing?
Supplements work best as part of a holistic approach. Prioritize regular sleep schedules, gentle movement like walking or yoga, eating nourishing whole foods, staying connected with supportive people, and allowing yourself time to process emotions. Journaling, spending time in nature, and creative expression can also support healing. Be patient and compassionate with yourself throughout the process.
