Best Supplements for Prediabetes (2026) – Top 10 Reviewed
Prediabetes affects over 96 million American adults, representing a critical window to prevent progression to type 2 diabetes. If you’ve been diagnosed with prediabetes, targeted supplements can support your efforts to reverse this condition when combined with lifestyle changes. This guide reviews the most effective supplements for prediabetes based on clinical research and expert recommendations.
Our Top Picks at a Glance
- Best Overall: PurePremium Blood Sugar Support – complete prediabetes formula
- Best Berberine: Ultimate Berberine Phytosome – superior absorption technology
- Best Value: Best Naturals Alpha Lipoic Acid – affordable antioxidant support
Quick Comparison
| Product | Key Ingredients | Form | Servings | Best For |
|---|---|---|---|---|
| PurePremium Blood Sugar Support | 20 active ingredients | Capsules | 60 | Comprehensive approach |
| Ultimate Berberine Phytosome | Enhanced berberine | Capsules | 60 | Maximum absorption |
| Best Naturals ALA 300mg | Alpha Lipoic Acid | Capsules | 120 | Budget-friendly |
| Ceylon Cinnamon Powder | Organic Ceylon Cinnamon | Powder | Varies | Natural approach |
| Ceylon Cinnamon Sticks | True Ceylon Cinnamon | Sticks | Varies | Tea and cooking |
| Best Naturals ALA 200mg | Alpha Lipoic Acid | Capsules | 120 | Lower dose option |
| GLP-1 Support Gummies | Multiple ingredients | Gummies | 60 | Appetite control |
1. PurePremium Normal Blood Sugar Support – Best Overall
- NORMAL BLOOD SUGAR SUPPORT SUPPLEMENT: Formulated to support healthy glucose levels already within the normal range. With a powerful blend of 20 active ingredients, including cinnamon, this supplement supports healthy cardiovascular function and overall wellness.*
- 20 ACTIVE INGREDIENTS: Our high potency blood sugar complex features 20 active ingredients, including Vitamin C, Vitamin E, Zinc, Biotin, Magnesium, Taurine, Alpha-Lipoic Acid, Chromium, Cinnamon, and more, to support the immune system and help you stay healthy and energized.*
- SUPPORTS NORMAL CARDIOVASCULAR HEALTH: Formulated with ingredients like cinnamon, magnesium, and chromium, this supplement helps support normal healthy blood circulation, normal heart function, and maintain overall cardiovascular well-being.*
- 120 DAYS SUPPLY: With 120 easy-to-swallow capsules per bottle, this supplement offers a two-month supply, providing lasting support for your blood sugar and overall health with just one capsule a day.*
- MADE IN THE USA FROM GLOBALLY SOURCED INGREDIENTS: PurePremium Supplements are manufactured in a USA-based facility that complies with all cGMP standards as certified by NSF. Additionally, each batch of our Supplement is tested by a third-party laboratory.
PurePremium delivers the most comprehensive prediabetes support available, combining 20 scientifically studied ingredients that work synergistically to support healthy blood sugar levels.
This advanced formula addresses prediabetes from multiple angles, including insulin sensitivity, glucose metabolism, inflammation reduction, and antioxidant protection. Each ingredient is included at research-backed dosages, making this an excellent choice for those serious about reversing prediabetes naturally.
What We Like
- 20-ingredient formula targets multiple metabolic pathways
- Contains berberine, alpha lipoic acid, chromium, and cinnamon
- Research-backed dosages of key compounds
What Could Be Better
- Requires multiple capsules per serving
- Higher price point than single-ingredient supplements
Bottom Line: The most complete supplement for prediabetes management, offering comprehensive support through multiple evidence-based ingredients.
2. Ultimate Berberine Phytosome – Best Berberine
- In each 1,000 mg serving, Ultimate Berberine has 𝟱𝟱𝟬 𝗺𝗴 𝗼𝗳 𝗕𝗲𝗿𝗯𝗲𝗿𝗶𝗻𝗲 𝗣𝗵𝘆𝘁𝗼𝘀𝗼𝗺𝗲 for Optimal Absorption and 𝟰𝟱𝟬 𝗺𝗴 𝗼𝗳 𝗕𝗲𝗿𝗯𝗲𝗿𝗶𝗻𝗲 𝗛𝗖𝗟 for additional support.
- 𝗕𝗲𝗿𝗯𝗲𝗿𝗶𝗻𝗲 𝗣𝗵𝘆𝘁𝗼𝘀𝗼𝗺𝗲 𝗶𝘀 𝗮 𝗰𝗼𝗺𝗽𝗼𝘂𝗻𝗱 𝗲𝘅𝘁𝗿𝗮𝗰𝘁𝗲𝗱 𝗳𝗿𝗼𝗺 𝗜𝗻𝗱𝗶𝗮𝗻 𝗯𝗮𝗿𝗯𝗲𝗿𝗿𝘆. It provides free-radical fighting activity, 𝗶𝗺𝗺𝘂𝗻𝗲 𝘀𝘆𝘀𝘁𝗲𝗺 𝘀𝘂𝗽𝗽𝗼𝗿𝘁, and 𝗽𝗿𝗼𝗽𝗲𝗿 𝗺𝗶𝗰𝗿𝗼𝗯𝗶𝗼𝗺𝗲 𝗯𝗮𝗹𝗮𝗻𝗰𝗲. 𝗜𝘁 𝗵𝗲𝗹𝗽𝘀 𝗮𝗰𝘁𝗶𝘃𝗮𝘁𝗲 𝗔𝗠𝗣𝗞, also known as the body's metabolic master switch. Ultimate Berberine with Berberine Phytosome and Berberine HCL 𝗵𝗲𝗹𝗽𝘀 𝘀𝘂𝗽𝗽𝗼𝗿𝘁 𝗴𝗮𝘀𝘁𝗿𝗼𝗶𝗻𝘁𝗲𝘀𝘁𝗶𝗻𝗮𝗹 𝗵𝗲𝗮𝗹𝘁𝗵, 𝗰𝗵𝗼𝗹𝗲𝘀𝘁𝗲𝗿𝗼𝗹, 𝗮𝗻𝗱 𝗹𝗶𝗽𝗶𝗱 𝗹𝗲𝘃𝗲𝗹𝘀 within normal ranges*
- 𝗩𝗲𝗴𝗮𝗻, 𝗡𝗼𝗻-𝗚𝗠𝗢, 𝗚𝗹𝘂𝘁𝗲𝗻-𝗳𝗿𝗲𝗲 - Our Doctor formulated Berberine with is made with 100% Natural, Vegan, Non-GMO, Gluten-free ingredients. Our capsules contain NO Fillers, Soy, Preservatives, Binders, or chemicals.
- 𝗧𝗲𝘀𝘁𝗲𝗱 & 𝗧𝗿𝘂𝘀𝘁𝗲𝗱 𝗜𝗻𝗴𝗿𝗲𝗱𝗶𝗲𝗻𝘁𝘀 - Our non-GMO, soy-free, gluten-free and dairy-free, berberine capsules supplements is formulated in the USA, in a registered, approved, inspected state-of-the-art facility, with strict adherence to Good Manufacturing Practices (GMP). Each and Every batch is 3rd Party Tested for Quality, Purity, Potency and Contamination.
- 𝗧𝗿𝘂𝘀𝘁𝗲𝗱 𝗕𝗿𝗮𝗻𝗱 - Satisfaction Assured - If our Berberine supplement pills do not bring noticeable value to you and you don't absolutely love them, your purchase is on us. No Questions Asked. Our world-class customer service wants you to be satisfied with your purchase. Absolutely no risk. The bottle comes with a Money-Back Guarantee.
Ultimate Berberine uses cutting-edge phytosome technology to dramatically increase berberine absorption, delivering superior results for prediabetes management.
Traditional berberine supplements have poor bioavailability, with the body absorbing only a small fraction of what you consume. This advanced formulation bonds berberine to phospholipids, increasing absorption rates up to 10 times compared to standard berberine. Research shows berberine can lower HbA1c levels comparable to some diabetes medications.
What We Like
- Phytosome technology provides exceptional absorption
- Lower doses needed compared to standard berberine
- Reduced digestive side effects
What Could Be Better
- Premium pricing reflects advanced technology
- Newer formulation with limited long-term data
Bottom Line: The most effective berberine supplement for prediabetes, offering superior absorption and results worth the premium price.
3. Best Naturals Alpha Lipoic Acid 300mg – Best Value
- 3rd Party Lab Tested for Purity & Quality.
- 300 mg of Alpha Lipoic Acid per Capsule - 120 Capsules per Bottle.
- Non-GMO & Gluten Free.
- Proudly Made in USA, GMP Compliant, FDA Registered Facility.
- No Artificial Color, Flavor or Sweetener, No Preservatives, No Sugar, No Milk, No Corn, No Soy, No Egg, No Lactose, No Gluten, No Wheat, No Yeast, No Fish. Sodium Free.
Best Naturals provides pharmaceutical-grade alpha lipoic acid at an exceptional value, supporting insulin sensitivity and antioxidant protection for prediabetes management.
Alpha lipoic acid is a powerful antioxidant that improves glucose uptake, reduces oxidative stress, and supports healthy insulin function. At 300mg per capsule with 120 servings per bottle, this supplement offers outstanding value for daily prediabetes support.
What We Like
- Pure, high-quality alpha lipoic acid at clinical dose
- 120 capsules provide 4-month supply
- Excellent price per serving
What Could Be Better
- Contains only one ingredient versus combination formulas
- Standard form rather than R-lipoic acid
Bottom Line: An affordable, effective option for adding proven alpha lipoic acid support to your prediabetes management plan.
4. 5-in-1 Ceylon Cinnamon Powder Extra Strength
- True Ceylon Strength: Each serving delivers 1000 mg of Ceylon Cinnamon (20:1 True Cinnamon extract, Cinnamomum verum) in gentle, easy-to-take cinnamon capsules.
- Complete 5-in-1 Synergy: Includes organic Ceylon cinnamon powder, turmeric, apple cider vinegar, Korean ginseng, and BioPerine for a well-rounded boost beyond typical cinnamon supplements.
- Balanced Support Every Day: This blend of Cinnamomum Verum and synergistic botanicals supports balance, drive, and a mindful routine, offering more than just cinnamon bark benefits.
- Maximized Absorption: BioPerine enhances nutrient use so your cinnamon pills maximize the benefits from every serving, delivering optimal effectiveness for reliable results.
- Easy Daily Routine: Take 3 capsules daily with water and a meal. Works well with a balanced lifestyle, making this Ceylon cinnamon supplement simple to keep in your wellness routine.
This organic Ceylon cinnamon powder provides a natural, food-based approach to prediabetes support that you can easily incorporate into your daily routine.
Ceylon cinnamon, known as “true cinnamon,” contains lower coumarin levels than Cassia cinnamon, making it safer for long-term daily use. Research shows cinnamon can improve fasting blood glucose, reduce insulin resistance, and support healthy post-meal blood sugar responses.
What We Like
- Organic Ceylon cinnamon from Sri Lanka
- Versatile powder form for foods and beverages
- Safer for long-term use than Cassia cinnamon
What Could Be Better
- Requires measuring and mixing into foods
- Taste may not appeal to everyone
Bottom Line: An excellent natural option for those who prefer whole-food approaches and want to avoid capsules.
5. Ceylon Cinnamon Sticks from Sri Lanka
- Unique taste: One of the best parts about our bulk cinnamon sticks is their floral, soft, and citrusy aromatic properties. The first pick for most chefs, the delicate, soft, and buttery Ceylon cinnamon stick is perfect for stews, curries, pastries, and multiple recipes
- Naturally harvested: The true cinnamon is harvested after about two years of growth. The inner bark is removed and later cut into strips, rolled into quills, and ultimately dried into what you will receive directly on your table
- Natural color: Our 5 inches ceylon cinnamon are filled and composed of layers of cinnamon bark. With a light brown or tan color, it is lighter in flavor and rarer by variety
- In Mexico, cinnamon is known as "canela", and the cinnamon used in Mexican cuisine from café de olla to traditional desserts is almost always Ceylon cinnamon sticks. Despite its widespread use, Mexico doesn’t grow cinnamon commercially. Instead, it imports most of it primarily from Sri Lanka, making it one of the top importers of Ceylon cinnamon globally.
True Ceylon cinnamon sticks offer the purest form of this blood sugar-supporting spice, perfect for making therapeutic cinnamon tea or adding to recipes.
These authentic Ceylon cinnamon sticks from Sri Lanka can be steeped in hot water for tea, ground fresh for maximum potency, or added to cooking. Many people with prediabetes find daily cinnamon tea to be an enjoyable and effective way to incorporate this beneficial spice into their routine.
What We Like
- Authentic Ceylon cinnamon in whole stick form
- Ideal for making therapeutic cinnamon tea
- No fillers, additives, or processing
What Could Be Better
- Requires preparation time for tea or grinding
- Difficult to standardize dosage
Bottom Line: The purest form of Ceylon cinnamon available, perfect for making daily blood sugar-supporting tea.
6. Best Naturals Alpha Lipoic Acid 200mg
- 3rd Party Lab Tested for Purity & Quality. 200 mg of Alpha Lipoic Acid per Capsule - 120 Capsules per Bottle. Non-GMO & Gluten Free. Proudly Made in USA, GMP Compliant, FDA Registered Facility. No Artificial Color, Flavor or Sweetener, No Preservatives, No Sugar, No Milk, No Corn, No Soy, No Egg, No Lactose, No Gluten, No Wheat, No Yeast, No Fish. Sodium Free.
Best Naturals 200mg option provides a lower starting dose of alpha lipoic acid, ideal for those new to supplementation or sensitive to higher doses.
Starting with a lower dose allows you to assess tolerance before moving to higher therapeutic doses. You can take one or two capsules depending on your needs, providing flexibility as you dial in your optimal dosage for prediabetes management.
What We Like
- Lower dose perfect for starting supplementation
- Can adjust dosage by taking one or two capsules
- Same quality as Best Naturals 300mg product
What Could Be Better
- May eventually need to graduate to higher dose
- Less economical than 300mg if taking multiple capsules
Bottom Line: An excellent entry point for alpha lipoic acid supplementation with flexible dosing options.
7. GLP-1 Support Gummies – Sugar-Free
- [Supports GLP-1 Function Naturally*] These sugar-free gummies are designed to support GLP-1 pathways that influence fullness, digestion, and wellness rhythms using plant-based ingredients backed by emerging science.
- [3-6 Week Ramp Up - Realistic Timeline Expectations] Natural GLP1 production from Plant-based supplements happen gradually - most users begin noticing subtle support within 3 to 6 weeks with consistent daily use as part of their routine. 8-12 weeks is optimal for ramp, and daily use is critical.
- [Berberine-Enhanced Wellness Formula] This GLP-1 support supplement for weight loss includes 95% pure berberine HCL, a powerful botanical traditionally used to support appetite suppression, fat burn, weight loss, and overall wellness as part of a healthy lifestyle.
- [Metabolic Health* & Energy Balance] With turmeric, cinnamon, and garcinia cambogia, this blend helps support a balanced metabolism and steady energy levels without the use of caffeine or synthetic stimulants.
- [Vegan & Gut-Friendly Ingredients] Made with plant-based pectin, not gelatin. These Gluten-free, non-GMO, GLP-1 supplement gummies are formulated with inulin fiber to support digestive comfort and clean daily supplementation.
These innovative gummies support natural GLP-1 production while helping control appetite and cravings, addressing two key challenges in prediabetes management.
GLP-1 is a hormone that regulates blood sugar and appetite. This sugar-free formula combines ingredients that support natural GLP-1 activity with compounds that help reduce cravings, making it easier to maintain the dietary changes essential for reversing prediabetes.
What We Like
- Sugar-free formula safe for prediabetes
- Supports appetite control and craving reduction
- Convenient gummy format
What Could Be Better
- Newer category with less long-term research
- Contains sugar alcohols that may cause digestive upset
Bottom Line: A modern approach combining blood sugar support with appetite control for comprehensive prediabetes management.
How to Choose the Best Supplements for Prediabetes
When selecting prediabetes supplements, prioritize ingredients with strong clinical evidence. Berberine has the most robust research, with studies showing it can reduce fasting blood glucose and HbA1c levels significantly, sometimes matching the effectiveness of metformin. Alpha lipoic acid offers powerful antioxidant protection while improving insulin sensitivity. Chromium helps insulin work more effectively, particularly beneficial if you have a deficiency. Ceylon cinnamon provides a gentler, food-based approach with consistent research supporting modest blood sugar improvements.
Consider your current lifestyle and health status when choosing supplements. If you’re already taking medications, berberine can interact with certain drugs and enhance blood sugar-lowering effects, requiring medical supervision. Those with digestive sensitivities may tolerate alpha lipoic acid or cinnamon better than berberine initially. If you struggle with taking pills, cinnamon powder or gummies might improve compliance compared to multiple capsules daily.
Quality markers separate effective supplements from inferior products. Look for third-party testing certification from USP, NSF International, or ConsumerLab to ensure purity and potency. For berberine, standardized extracts containing 97% pure berberine HCl are ideal. Ceylon cinnamon should be verified as authentic Ceylon rather than cheaper Cassia cinnamon sold as Ceylon. Alpha lipoic acid products should clearly state the amount per serving and avoid proprietary blends that hide actual dosages.
Dosage timing matters for prediabetes supplements. Berberine works best when split into two or three doses taken with meals, typically 500mg each time for 1000-1500mg daily total. This matches your body’s natural insulin response to food. Alpha lipoic acid can be taken once or twice daily, usually 300-600mg total. Chromium is typically taken once daily with food, around 200-400mcg. Cinnamon can be consumed throughout the day in food or as a single supplement dose.
Think long-term when choosing prediabetes supplements since reversing this condition requires sustained effort over months. Select products you’ll consistently take rather than complex regimens you’ll abandon. A single comprehensive formula may work better than juggling multiple bottles. Consider cost-per-day calculations rather than just bottle price, as some premium products last longer or work more effectively at lower doses, ultimately providing better value.
Benefits of Prediabetes Supplements
The primary benefit of prediabetes supplements is potentially reversing progression toward type 2 diabetes. Research shows that improving insulin sensitivity and lowering blood glucose can help many people move from prediabetes back to normal glucose tolerance. Supplements like berberine and alpha lipoic acid support the metabolic improvements that make this reversal possible when combined with lifestyle changes including diet modification and increased physical activity.
Cardiovascular protection represents another crucial benefit for people with prediabetes. This condition significantly increases heart disease risk even before diabetes develops. Berberine improves lipid profiles by reducing LDL cholesterol and triglycerides while potentially raising protective HDL cholesterol. Alpha lipoic acid provides antioxidant protection for blood vessels and may help prevent the vascular damage that prediabetes can cause over time.
Weight management often becomes easier with prediabetes supplements because they address the metabolic dysfunction that makes losing weight difficult. When insulin resistance is present, elevated insulin levels promote fat storage and increase hunger. By improving insulin sensitivity, supplements help create a more favorable metabolic state for weight loss. Better blood sugar control also reduces the energy crashes and cravings that sabotage healthy eating efforts.
Reduced inflammation provides widespread health benefits beyond blood sugar control. Chronic inflammation contributes to insulin resistance and increases risk for numerous diseases. Many prediabetes supplements including berberine, alpha lipoic acid, and cinnamon possess anti-inflammatory properties that help break the cycle between inflammation and metabolic dysfunction. This may improve overall health markers beyond just glucose and insulin levels.
Frequently Asked Questions
Can supplements reverse prediabetes without lifestyle changes?
Supplements alone cannot reverse prediabetes effectively without lifestyle modifications. While berberine and other supplements can significantly improve blood sugar metrics, research shows the best results occur when supplements complement dietary changes emphasizing whole foods and reduced refined carbohydrates, regular physical activity, adequate sleep, and stress management. Think of supplements as supportive tools that enhance your lifestyle efforts rather than replacements for healthy habits.
What is the most effective supplement for prediabetes?
Berberine is widely considered the most effective single supplement for prediabetes based on extensive research showing it can lower fasting blood glucose and HbA1c levels comparable to some diabetes medications. Studies demonstrate berberine improves insulin sensitivity through multiple mechanisms including AMPK activation. However, comprehensive formulas combining berberine with alpha lipoic acid, chromium, and other ingredients often provide superior results by addressing prediabetes through multiple pathways simultaneously.
How long does it take to reverse prediabetes with supplements?
Most people begin seeing blood sugar improvements within 2-4 weeks of starting quality prediabetes supplements, but reversing prediabetes typically requires 3-6 months of consistent effort combining supplementation with lifestyle changes. Your doctor can track progress through regular HbA1c testing every 3 months. Some people achieve normal glucose tolerance within 6 months, while others require a year or more depending on individual factors like starting HbA1c level, weight loss achieved, and exercise consistency.
Are prediabetes supplements safe long-term?
Most prediabetes supplements are safe for long-term use when taken at appropriate doses under medical supervision. Berberine has been used in traditional medicine for thousands of years with a strong safety profile at 1000-1500mg daily. Alpha lipoic acid shows no concerning long-term effects at 300-600mg daily. Ceylon cinnamon is safer than Cassia for extended use due to lower coumarin content. However, regular monitoring of blood sugar and periodic check-ins with your healthcare provider ensure continued safety and effectiveness.
Can I take prediabetes supplements with metformin?
You should consult your healthcare provider before combining prediabetes supplements with metformin, as berberine in particular has blood sugar-lowering effects that may enhance metformin’s action and potentially cause hypoglycemia. Your doctor may need to adjust medication dosages when adding supplements. Some research suggests berberine combined with metformin may work better than either alone, but this combination requires professional supervision to ensure safety and optimal blood sugar control.
Do I need to take prediabetes supplements forever?
Many people can discontinue prediabetes supplements once they’ve reversed the condition and maintain normal blood sugar through lifestyle habits alone. However, supplements may provide long-term preventive benefits even after reversing prediabetes. Work with your healthcare provider to determine the right approach for your situation. Some people continue low-dose supplementation as insurance against relapse, while others successfully maintain normal glucose tolerance through diet and exercise without ongoing supplementation.
What foods should I eat with prediabetes supplements?
Focus on whole foods including non-starchy vegetables, lean proteins, healthy fats, and controlled portions of complex carbohydrates like legumes and whole grains. This dietary pattern works synergistically with prediabetes supplements to improve insulin sensitivity. Avoid refined carbohydrates, added sugars, and highly processed foods that spike blood sugar and counteract supplement benefits. Taking supplements with balanced meals containing protein, fiber, and healthy fats optimizes their effectiveness while supporting stable blood sugar throughout the day.
Can cinnamon alone reverse prediabetes?
While cinnamon shows blood sugar benefits in research, it’s unlikely to reverse prediabetes as a standalone treatment. Studies show cinnamon produces modest improvements in fasting blood glucose and insulin sensitivity, typically smaller effects than berberine or comprehensive lifestyle changes. However, cinnamon can be a valuable component of a multi-faceted approach including other supplements, dietary modifications, and exercise. Its safety profile and pleasant taste make it an excellent addition to your prediabetes management strategy even if not sufficient alone.
